Benzene Ring Bonded Directly To The Diazole Ring Patents (Class 548/354.1)
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Patent number: 8877936Abstract: This invention relates generally to olefin metathesis, more particularly, to tri- or tetra-substituted imidazolinium salts which are precursors to N-heterocyclic carbene (NHC) ligands with tri- or tetra-substituted imidazolinium rings, organometallic ruthenium complexes comprising gem di-substituted imidazolinium NHC ligands, organometallic ruthenium complexes comprising tri- or tetra-substituted imidazolinium NHC ligands, and to olefin metathesis methods using them. The catalysts and methods of the invention have utility in the fields of catalysis, organic synthesis, and industrial chemistry.Type: GrantFiled: April 9, 2009Date of Patent: November 4, 2014Assignee: California Institute of TechnologyInventors: Robert H. Grubbs, Cheol Keun Chung, Jean-Baptiste Bourg, Kevin Kuhn
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Publication number: 20140275555Abstract: Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Massachusetts Institute of TechnologyInventors: Jeremiah A. Johnson, Aleksandr V. Zhukhovitskiy
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Publication number: 20140249163Abstract: The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition. The present disclosure also describes a method for inhibiting such Ras-induced or mediated cellular processes. The method entails administering a Ras antagonist in an amount effective to inhibit such cellular processes.Type: ApplicationFiled: October 5, 2012Publication date: September 4, 2014Applicant: PICES THERAPEUTICS LLCInventors: James H. Wikel, Michael J. Brownstein
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Patent number: 8703965Abstract: Methods for the preparation of saturated imidazolinium salts and related compounds that comprises reaction of formamidines with compounds such as dihaloethane and an optional base are disclosed. Alternatively, the imidazolinium salts and related compounds can be prepared in a one-step process without purification of the formamidine reactant. These methods make it possible to obtain numerous imidazolinium salts and related compounds under solvent-free reaction conditions and in excellent yields.Type: GrantFiled: November 10, 2008Date of Patent: April 22, 2014Assignees: Materia, Inc., California Institute of TechnologyInventors: Kevin Kuhn, Robert H. Grubbs
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Publication number: 20130281709Abstract: An object of the present invention is to produce an ?-hydroxyketone compound easily and effectively. Provided is a process for producing an ?-hydroxyketone compound comprising a stirring step of stirring one or more aldehyde compounds or polymers thereof in the presence of a base and an imidazolinium salt represented by the formula (1): wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group optionally having a substituent or an aryl group optionally having a substituent, or R1 and R2 are bound to each other to form a ring together with carbon atoms to which they bind, R3 and R4 each independently represent an aryl group having one or more electron withdrawing groups, and X? represents an anion.Type: ApplicationFiled: January 27, 2012Publication date: October 24, 2013Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Koji Hagiya
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Publication number: 20120316341Abstract: Methods for fluorinating organic compounds are described herein.Type: ApplicationFiled: April 11, 2012Publication date: December 13, 2012Inventors: Tobias Ritter, Pingping Tang
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Publication number: 20120001163Abstract: A photoelectric conversion element is provided which includes a photoelectrode (101) having a porous semiconductor layer (106) and a transparent electrode (107) and a counter electrode (102) disposed to face the photoelectrode (101) and in which a nitroxyl radical compound expressed by General Formula 1 is mainly enclosed between the photoelectrode (101) and the counter electrode (102). (where A in General Formula 1 represents a substituted or unsubstituted aromatic group and may contain one or more atoms of oxygen, nitrogen, sulfur, silicon, phosphorus, boron, or halogen and the aromatic group may be obtained by condensing a plurality of aromatic groups).Type: ApplicationFiled: March 4, 2010Publication date: January 5, 2012Applicant: NEC CORPORATIONInventors: Kenji Kobayashi, Kentaro Nakahara, Masahiro Suguro, Shin Nakamura
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Publication number: 20110308617Abstract: A photoelectric conversion element is provided which includes a semiconductor electrode (108) containing a semiconductor layer (103) and a dye, a counter electrode (109), and an electrolyte layer (104) disposed between the semiconductor electrode (108) and the counter electrode (109) and in which the dye contains a compound expressed by General Formula 1. (where A in General Formula 1 represents a substituted or unsubstituted aromatic group and may contain one or more atoms of oxygen, nitrogen, sulfur, silicon, phosphorus, boron, or halogen and the aromatic group may be obtained by condensing a plurality of aromatic groups).Type: ApplicationFiled: March 4, 2010Publication date: December 22, 2011Applicant: NEC CORPORATIONInventors: Kentaro Nakahara, Kenji Kobayashi, Masahiro Suguro, Shin Nakamura
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Publication number: 20110124868Abstract: This invention relates generally to olefin metathesis, more particularly, to tri- or tetra-substituted imidazolinium salts which are precursors to N-heterocyclic carbene (NHC) ligands with tri- or tetra-substituted imidazolinium rings, organometallic ruthenium complexes comprising gem di-substituted imidazolinium NHC ligands, organometallic ruthenium complexes comprising tri- or tetra-substituted imidazolinium NHC ligands, and to olefin metathesis methods using them. The catalysts and methods of the invention have utility in the fields of catalysis, organic synthesis, and industrial chemistry.Type: ApplicationFiled: April 9, 2009Publication date: May 26, 2011Applicants: MATERIA, INC., CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Robert H. Grubbs, Cheol Keun Chung, Jean-Baptiste Bourg, Kevin Kuhn
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Publication number: 20110087032Abstract: Methods for the preparation of saturated imidazolinium salts and related compounds that comprises reaction of formamidines with compounds such as dihaloethane and an optional base are disclosed. Alternatively, the imidazolinium salts and related compounds can be prepared in a one-step process without purification of the formamidine reactant. These methods make it possible to obtain numerous imidazolinium salts and related compounds under solvent-free reaction conditions and in excellent yields.Type: ApplicationFiled: November 10, 2008Publication date: April 14, 2011Applicants: MATERIA, INC., CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Kevin Kuhn, Robert H. Grubbs
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Publication number: 20110034463Abstract: The invention, in some aspects, relates to compounds and compositions useful for inhibiting Type III secretion systems in pathogenic bacteria, such as Yersinia Pestis. In some aspects, the invention relates to methods for discovering inhibitors of the Type III secretion system and uses of such inhibitors in the treatment and prevention of disease.Type: ApplicationFiled: April 1, 2009Publication date: February 10, 2011Inventors: Jon Goguen, Ning Pan, Kyungae Lee
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Patent number: 7851626Abstract: There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.Type: GrantFiled: November 27, 2006Date of Patent: December 14, 2010Assignee: Hoffmann-La Roche Inc.Inventors: Qingjie Ding, Bradford James Graves, Norman Kong, Jin-Jun Liu, Allen John Lovey, Giacomo Pizzolato, John Lawson Roberts, Sung-Sau So, Binh Thanh Vu, Peter Michael Wovkulich
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Publication number: 20100041898Abstract: Disclosed is a new class of chiral bidentate ligands capable of performing asymmetric hydrogenation. Also disclosed are processes of performing asymmetric hydrogenation the chiral bidentate ligands.Type: ApplicationFiled: November 20, 2007Publication date: February 18, 2010Applicant: Boehringer Ingelheim International GmbHInventors: Carl Alan Busacca, Jon Charles Lorenz
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Patent number: 7538228Abstract: A chiral ligand represented by the formula and its enantiomer: wherein A, X, Y and Z are as defined in the specification is provided. Also provided is a process of making the chiral ligands and catalysts prepared from these ligands and a transition metal, a salt thereof or a complex thereof. In addition, a method of preparing an asymmetric compound by a transition metal catalyzed asymmetric reaction, such as, hydrogenation, hydride transfer reaction, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, allylic alkylation, epoxidation, cyclopropanation, Diels-Alder reaction, Aldol reaction, ene reaction, Heck reaction and Michael addition is provided.Type: GrantFiled: December 17, 2004Date of Patent: May 26, 2009Assignee: The Penn State Research FoundationInventors: Xumu Zhang, Duan Liu
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Patent number: 7446165Abstract: The present invention relates to a novel benzimidazole compound represented by formula 1. The novel benzimidazole compound of the present invention is very useful for the production of polymers used as a functional polymer thin film by polymerization with bishydroxy compound. Wherein, X is a halogen such as F, Cl, Br or I, Y is a functional group having strong electron-drawing force such as nitro (—NO2) or trifluoromethyl (—CF3).Type: GrantFiled: August 10, 2005Date of Patent: November 4, 2008Assignee: LG Chem, Ltd.Inventors: Chong-kyu Shin, Young-ji Tae, Bong-keun Lee
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Publication number: 20080269217Abstract: Provided are MC4-R binding compounds of the formula XVII: wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also provided.Type: ApplicationFiled: May 1, 2008Publication date: October 30, 2008Applicant: Ore Pharmaceuticals, Inc.Inventors: Tricia J. Vos, Michael E. Solomon, Christopher F. Claiborne, Martin P. Maguire, Mingshi Dai, Michael Patane, Thoma H. Marsilje
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Patent number: 7375125Abstract: Provided are MC4-R binding compounds of the formula XVII: wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also provided.Type: GrantFiled: June 16, 2003Date of Patent: May 20, 2008Assignee: Ore Pharmaceuticals, Inc.Inventors: Tricia J. Vos, Michael E. Solomon, Christopher F. Claiborne, Martin P. Maguire, Mingshi Dai, Michael Patane, Thomas H. Marsilje
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Patent number: 7125725Abstract: A novel achiral biaryl-type compound and a circular dichroism(CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chiral compound.Type: GrantFiled: February 25, 2004Date of Patent: October 24, 2006Assignee: Kanazawa UniversityInventors: Tomihisa Ohta, Shinzo Hosoi
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Patent number: 7041856Abstract: There are disclosed a process for producing a coupling compound of formula (1): (Y—)(n?1)R1—R2—(R1)(n??1),??(1) wherein R1 and R2 independently represent a substituted or unsubstituted aryl group, which process is characterized by reacting an unsaturated organic compound of formula (2): n?(R1X1n)??(2) wherein n, n?, and R1 are the same as defined above, and X1 is the same or different and independently represents a leaving group and bonded with a sp2 carbon atom of R1 group, with a boron compound of formula (3): m{R2(BX22)n?}??(3) wherein R2 and n? are the same as defined above, X2 represents a hydroxy group, an alkoxy group, in the presence of a catalyst containing (A) a nickel compound, and (B) a nitrogen-containing cyclic compound, and the catalyst.Type: GrantFiled: October 22, 2002Date of Patent: May 9, 2006Assignee: Sumitomo Chemical Company, LimitedInventors: Tamon Itahashi, Takashi Kamikawa
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Publication number: 20040198779Abstract: The invention relates to novel heterocycle substituted diphenyl leukotriene B4 (LTB4) antagonists, to compositions containing such compounds, and to methods of using such compounds for treatment of inflammatory diseases.Type: ApplicationFiled: January 28, 2004Publication date: October 7, 2004Inventors: Jason Scott Sawyer, Douglas Wade Beight, Edward C. R. Smith, William Thomas McMillen
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Patent number: 6784183Abstract: Compounds of formula (I): and medicinal products containing the same which are useful as dual &agr;2/5-HT2c antagonists.Type: GrantFiled: June 29, 2001Date of Patent: August 31, 2004Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Olivier Muller, Mark Millan, Anne Dekeyne, Mauricette Brocco
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Patent number: 6727098Abstract: A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chiral compound.Type: GrantFiled: February 26, 2002Date of Patent: April 27, 2004Assignee: Kanazawa UniversityInventors: Tomihisa Ohta, Shinzo Hosoi
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Publication number: 20030236413Abstract: The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one ligand comprising at least one imine function and at least one supplemental nitrogen atom as the chelating atoms.Type: ApplicationFiled: May 31, 2002Publication date: December 25, 2003Inventors: Pascal Philippe Cellier, Henri-Jean Cristau, Jean-Francis Spindler, Marc Taillefer
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Publication number: 20030232811Abstract: The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.Type: ApplicationFiled: January 31, 2003Publication date: December 18, 2003Applicant: TEIJIN LIMITEDInventors: Naoki Tsuchiya, Susumu Takeuchi, Takumi Takeyasu, Naoki Hase, Takao Yamori, Takashi Tsuruo
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Publication number: 20030229091Abstract: Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): 1Type: ApplicationFiled: September 5, 2002Publication date: December 11, 2003Inventors: Andreas Termin, Peter D.J. Grootenhuis, Dean M. Wilson, Valentina Molteni, Long Mao, Angelo Castellino, Zhicai Yang, Anthony Pechulis, Mark Suto
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Publication number: 20030220498Abstract: A process for the production of compounds Ar—R1 by means of a cross-coupling reaction of an organometallic reagent R1—M with an aromatic or heteroaromatic substrate Ar—X catalyzed by one or several iron salts or iron complexes as catalysts or pre-catalysts, present homogeneously or heterogeneously in the reaction mixture. This new invention exhibits substantial advantages over established cross coupling methodology using palladium- or nickel complexes as the catalysts. Most notable aspects are the fact that (i) expensive and/or toxic nobel metal catalysts are replaced by cheap, stable, commercially available and toxicologically benign iron salts or iron complexes as the catalysts or pre-catalysts, (ii) commercially attractive aryl chlorides as well as various aryl sulfonates can be used as starting materials, (iii) the reaction can be performed under “ligand-free” conditons, and (iv) the reaction times are usually very short.Type: ApplicationFiled: May 10, 2002Publication date: November 27, 2003Inventors: Alois Furstner, Andreas Leitner, Maria Mendez
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Patent number: 6653300Abstract: This invention describes novel pyrazole compounds of formula I′: wherein Q′ is —O—, —C(R6′)2—, 1,2-cyclopropanediyl, 1,2-cyclobutanediyl, or 1,3-cyclopropanediyl, and R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T—R3 or L—Z—R3, or Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.Type: GrantFiled: December 19, 2001Date of Patent: November 25, 2003Assignee: Vertex Pharmaceuticals IncorporatedInventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Jeremy Green, David Kay, Ronald Knegtel, Andrew Miller, Ronald Tomlison, Pan Li
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Patent number: 6617346Abstract: The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activityType: GrantFiled: December 11, 2002Date of Patent: September 9, 2003Assignee: Hoffmann-La Roche Inc.Inventors: Norman Kong, Emily Aijun Liu, Binh Thanh Vu
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Publication number: 20030166643Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1Type: ApplicationFiled: December 11, 2002Publication date: September 4, 2003Applicant: WyethInventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Leo M. Albert
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Publication number: 20030162950Abstract: There are disclosed a process for producing a coupling compound of formula (1):Type: ApplicationFiled: October 22, 2002Publication date: August 28, 2003Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tamon Itahashi, Takashi Kamikawa
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Publication number: 20030158418Abstract: Compounds represented by the general formula (I): 1Type: ApplicationFiled: September 25, 2002Publication date: August 21, 2003Inventors: Nagaaki Sato, Osamu Okamoto, Makoto Jitsuoka, Keita Nagai, Akio Kanatani, Akane Ishihara, Yasuyuki Ishii, Takehiro Fukami
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Publication number: 20030153580Abstract: The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.Type: ApplicationFiled: December 11, 2002Publication date: August 14, 2003Inventors: Norman Kong, Emily Aijun Liu, Binh Thanh Vu
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Publication number: 20030149078Abstract: Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: 1Type: ApplicationFiled: December 13, 2002Publication date: August 7, 2003Applicant: Pharmacia CorporationInventors: David L. Brown, Matthew J. Graneto, Cindy L. Ludwig, John M. Molyneaux, John J. Talley
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Publication number: 20030144310Abstract: This invention provides a compound having the structure: 1Type: ApplicationFiled: September 24, 2002Publication date: July 31, 2003Inventors: Lakmal W. Boteju, Michael J. Konkel, Joel K. Kawakami, John Wetzel
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Publication number: 20030139607Abstract: Heterocyclically substituted benzoylguanidines of the formula I 1Type: ApplicationFiled: January 28, 2003Publication date: July 24, 2003Applicant: Aventis Pharma Deutschland GmbHInventors: Andreas Weichert, Udo Albus, Hans-Willi Jansen, Heinz-Werner Kleemann, Hans-Jochen Lang
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Publication number: 20030114465Abstract: Compounds of the formula I 1Type: ApplicationFiled: July 23, 2002Publication date: June 19, 2003Inventors: Andrew W. Stamford, Craig D. Boyle, Ying Huang
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Publication number: 20030088104Abstract: A novel achiral biaryl-type compound and a circular dichroism(CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chiral compound.Type: ApplicationFiled: February 26, 2002Publication date: May 8, 2003Applicant: KANAZAWA UNIVERSITYInventors: Tomihisa Ohta, Shinzo Hosoi
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Publication number: 20030069292Abstract: This invention relates to compounds having the Formula I: 1Type: ApplicationFiled: April 30, 2002Publication date: April 10, 2003Applicant: EURO-CELTIQUE S.A.Inventors: Derk Hogenkamp, Ravindra Upasani, Phong Nguyen
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Publication number: 20030008882Abstract: The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.Type: ApplicationFiled: May 8, 2002Publication date: January 9, 2003Inventors: Andrew D. Hamilton, Justin Ernst, Brendan P. Orner
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Patent number: 6495270Abstract: Nitrogen compounds represented by formula (XXIa) or (XXIb); an epoxy resin hardening accelerator and a resin composition each containing any of the compounds; and an electronic part device containing an element encapsulated with the composition. In the formulae, R1 and R2 each represents hydrogen or a C1-20 monovalent organic group; R3 and R4 each represents a C1-20 divalnt organic group; R5 represents hydrogen or a C1-6 monovalent organic group; k is an integer of 0 to 2; and p is 0 or 1.Type: GrantFiled: October 23, 2000Date of Patent: December 17, 2002Assignee: Hitachi Chemical Company, Ltd.Inventors: Mitsuo Katayose, Shinya Nakamura
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Publication number: 20020183334Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.Type: ApplicationFiled: October 26, 2001Publication date: December 5, 2002Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
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Patent number: 6479063Abstract: A method of decreasing atherosclerosis and its complications involving administering to a human or animal various combinations of medications with Finasteride, Bicalutamide, Flutamide and Nilutamide.Type: GrantFiled: December 26, 2000Date of Patent: November 12, 2002Inventors: Kenneth Weisman, Michael E. Goldberg
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Publication number: 20020099222Abstract: Heterocyclically substituted benzoylguanidines of the formula I 1Type: ApplicationFiled: February 15, 2002Publication date: July 25, 2002Inventors: Andreas Weichert, Udo Albus, Hans-Willi Jansen, Heinz-Werner Kleemann, Hans-Jochen Lang
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Patent number: 6380237Abstract: The invention relates to novel diphenylimidazolines of the formula (I) in which Ar1, Ar2 and R are each as defined in the description, and a plurality of processes for their preparation and to their use for controlling animal pests.Type: GrantFiled: February 5, 2001Date of Patent: April 30, 2002Assignee: Bayer AktiengesellschaftInventors: Alan Graff, Andrew Plant, Christoph Erdelen, Norbert Mencke, Andreas Turberg
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Patent number: 6376765Abstract: An electrolyte composition comprising a compound represented by the following general formula (1): wherein R represents a substituent containing a —(CR1R2—CR3R4—O)n— bond (in which R1 to R4 are independently a hydrogen atom or an alkyl group, n being an integer of 2 to 20); Q represents an atomic group forming an aromatic cation having a 5- or 6-membered ring structure with a nitrogen atom, which may have a substituent; and X− represents an anion. A photoelectric conversion device comprising the electrolyte composition and a photo-electrochemical cell composed thereof are also provided.Type: GrantFiled: August 3, 2000Date of Patent: April 23, 2002Assignee: Fuji Photo Film Co., Ltd.Inventors: Koji Wariishi, Chang-yi Qian, Michio Ono
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Publication number: 20020002195Abstract: A compound of formula (I): 1Type: ApplicationFiled: April 12, 2001Publication date: January 3, 2002Inventors: Jamin Huang, Scot Kevin Huber
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Publication number: 20010049446Abstract: Heterocyclically substituted benzoylguanidines of the formula I 1Type: ApplicationFiled: July 11, 2001Publication date: December 6, 2001Inventors: Andreas Weichert, Udo Albus, Hans-Willi Jansen, Heinz-Werner Kleemann, Hans-Jochen Lang
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Patent number: 6175013Abstract: This invention provides a series of substituted 2-imidazolines which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these compounds.Type: GrantFiled: June 10, 1994Date of Patent: January 16, 2001Assignee: Eli Lilly and CompanyInventors: Philip A. Hipskind, J. Jeffry Howbert, Brian S. Muehl
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Patent number: 6172239Abstract: The invention relates to compounds of the formula The compounds have agreat affinity for the neurotensin receptors.Type: GrantFiled: August 16, 1999Date of Patent: January 9, 2001Assignee: SanofiInventors: Bernard Labeeuw, Danielle Gully, Francis JeanJean, Jean-Charles Molimard, Robert Boigegrain