Two Double Bonds Between Ring Members Of The Diazole Ring (i.e., Pyrazole) Patents (Class 548/373.1)
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Patent number: 7994205Abstract: The present invention provides an aryl- or heteroaryl compound represented by the formula (Ia) or (Ib) wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. The compound has superior acid secretion inhibitory action, an antiulcer activity and the like.Type: GrantFiled: March 30, 2007Date of Patent: August 9, 2011Assignee: Takeda Pharmaceutical Company LimitedInventors: Atsushi Hasuoka, Terufumi Takagi, Haruyuki Nishida
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Patent number: 7989461Abstract: The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z?, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.Type: GrantFiled: December 20, 2006Date of Patent: August 2, 2011Assignee: Amgen Inc.Inventors: Frenel F. De Morin, Jian J. Chen, Stephen Hitchcock, Gang Liu, Nick A. Paras, Jeffrey Petkus, Adrian L. Smith, Andrew Tasker, Jiawang Zhu
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Publication number: 20110184188Abstract: The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W1 to W9, and R1 to R3 are as defined here-in.Type: ApplicationFiled: July 28, 2009Publication date: July 28, 2011Applicant: Bayer CropScience AGInventors: Katsuaki Wada, Yasushi Yoneta, Takuya Gomibuchi, Tetsuya Murata, Sachio Kudo, Hidetoshi Kishikawa, Katsuhiko Shibuya, Eiichi Shimojo, Akira Emoto, Yoshitaka Sato, Rüdiger Fisher, Christian Funke, Christian Arnold, Eva-Maria Franken, Olga Malsam, Erich Sanwald, Ulrich Görgens, Masashi Ataka, Udo Reckmann, Christian Paulitz, Tobias Kapferer
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Publication number: 20110178297Abstract: A process for the manufacture of a cyclic compound of formula (I) which comprises (a) adding an acid halide of formula R1—C (O)—X, to a vinyl ether of formula (II): CH2?CH—OR2, to produce an addition product, and (b) reacting the addition product with a compound of formula (III): Y-A-Z; wherein R1 is a halogenated alkyl group; wherein X is fluorine, chlorine, or bromine; wherein R2 is an alkyl group, an aralkyl group, or an aryl group; wherein Z and Y designate independently carbon or a heteroatom; and wherein A is a linking group between Z and Y comprising 0, 1, 2 or 3 atoms in the cycle.Type: ApplicationFiled: September 25, 2009Publication date: July 21, 2011Applicant: SOLVAY SAInventor: Max Braun
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Patent number: 7968584Abstract: This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.Type: GrantFiled: March 19, 2009Date of Patent: June 28, 2011Assignees: Pfizer Inc., Pfizer Products Inc.Inventors: Denis Billen, Jessica Boyle, Douglas James Critcher, David Morris Gethin, Kim Thomas Hall, Graham Michael Kyne
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Patent number: 7960426Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.Type: GrantFiled: February 3, 2009Date of Patent: June 14, 2011Assignee: Pfizer LimitedInventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
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Patent number: 7956054Abstract: In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.Type: GrantFiled: July 2, 2010Date of Patent: June 7, 2011Assignee: Theravance, Inc.Inventors: Brooke Blair, Paul R. Fatheree, Melissa Fleury, Roland Gendron, Ryan Hudson, Robert Murray McKinnell, Michael Wilson
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Patent number: 7956185Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.Type: GrantFiled: May 24, 2007Date of Patent: June 7, 2011Assignee: Abbott LaboratoriesInventors: Robert B. Diebold, Stevan W. Djuric, Vincent L. Giranda, Laura A. Hexamer, Nan-Horng Lin, Julie M. Miyashiro, Thomas D. Penning, Magdalena Przytulinska, Thomas J. Sowin, Gerard M. Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith W. Woods, Zhiren Xia, Henry Q. Zhang
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Patent number: 7951818Abstract: Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.Type: GrantFiled: November 30, 2007Date of Patent: May 31, 2011Assignee: Galapagos NVInventors: Paul John Edwards, Sébastien Laurent Xavier Martina, Martin James Inglis Andrews, Grégory Louis Joseph Bar, Brigitte Allart, Andrew Burritt, Xueliang Tao, Friedrich Erich Karl Kroll
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Patent number: 7947707Abstract: The present invention relates to novel compounds having a xanthine oxidase inhibitory effect and an uricosuric effect and pharmaceutical compositions comprising the same as an active ingredient. That is, the present invention relates nitrogen-containing heterocyclic compounds represented by the following general formula (I): wherein Y1 represents N or C(R4); Y2 represents N or C(R5); R4 and R5 independently represent an alkyl group, a hydrogen atom etc.; one of R1 and R2 represents an optionally substituted aryl group, an alkoxy group or an optionally substituted heterocyclic group; the other of R1 and R2 represents a haloalkyl group, a cyano group, a halogen atom etc.; and R3 represents a 5-tetrazolyl group or a carboxy group, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the same as an active ingredient.Type: GrantFiled: October 3, 2006Date of Patent: May 24, 2011Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Takahiro Toyoshima, Toshinobu Sasaki, Chikara Hoshino, Masakazu Takeda
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Patent number: 7947687Abstract: This invention comprises antineoplastic curcumin derivatives and methods of preparation and use thereof. Particular reference is made to the following isomeric compounds wherein R1, R2, and R3 are selected from the group consisting of H, OH, OCH3, and COOH.Type: GrantFiled: October 29, 2007Date of Patent: May 24, 2011Inventor: Byron C Robinson
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Patent number: 7943653Abstract: This invention is directed to a cannabinoid modulator compound of formula (I): or a form thereof, and methods for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.Type: GrantFiled: August 11, 2008Date of Patent: May 17, 2011Assignee: Janssen Pharmaceutica N.V.Inventors: Mingde Xia, Meng Pan, Michael P. Wachter
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Patent number: 7919633Abstract: There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purification of celecoxib using aromatic hydrocarbon solvents.Type: GrantFiled: March 19, 2008Date of Patent: April 5, 2011Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.Inventors: Raghupathi Reddy Anumula, Goverdhan Gilla, Sampath Alla, Thirupathi Reddy Akki, Yakambram Bojja
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Patent number: 7906656Abstract: This invention relates to novel intermediates used in the preparation of iodopyrazolylcarboxanilides of the formula (I) in which R1, R2, R3, R4, R5, R6 and Z are as defined in the disclosure, and to the preparation of such intermediates.Type: GrantFiled: February 5, 2010Date of Patent: March 15, 2011Assignee: Bayer CropScience AGInventors: Ralf Dunkel, Hans-Ludwig Elbe, Jörg Nico Greul, Benoit Hartmann, Ulrike Wachendorff-Neumann, Peter Dahmen, Karl-Heinz Kuck
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Publication number: 20110059975Abstract: The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.Type: ApplicationFiled: February 18, 2010Publication date: March 10, 2011Inventors: Joshua Kennedy-Smith, Wylie Solang Palmer, Zachary Kevin Sweeney
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Patent number: 7893611Abstract: There is provided a novel luminescent metal complex. A metal complex having a composition of [(PtII)2(MI)2(X)2(L)4(LH)2], where MI denotes AgI, AuI or CuI, X denotes Cl, Br or I, L denotes a structure represented by the formula (1), and LH denotes a structure represented by the formula (2).Type: GrantFiled: November 1, 2007Date of Patent: February 22, 2011Assignee: Nagasaki UniversityInventors: Keisuke Umakoshi, Seiji Akatsu, Masayoshi Onishi, Shoji Ishizaka, Noboru Kitamura
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Patent number: 7888289Abstract: A compound of general formula (I): A process for preparing this compound. A fungicide composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition comprising it.Type: GrantFiled: April 6, 2006Date of Patent: February 15, 2011Assignee: Bayer Cropscience AGInventors: Darren Mansfield, Pierre-Yves Coqueron, Philippe Desbordes, Heiko Rieck, Alain Villier, Pierre Genix, Marie-Claire Grosjean-Cournoyer
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Patent number: 7884216Abstract: The present invention provides a fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same, and a fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same. A fluorine-containing acyacrylonitrile derivative prepared from a fluoroacyl derivative and an aminoacrylonitrile derivative, is reacted with a hydrazine derivative to produce a fluorine-containing pyrazolecarbonitrile derivative represented by Formula (1). In Formula (1), Rf represents an alkyl group having 1 to 6 carbon atoms and substituted with at least one fluorine atom; R1 represents an alkyl group having 1 to 6 carbon atoms and R2 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like. The fluorine-containing pyrazolecarbonitrile derivative represented by Formula (1) is reacted with water to produce a fluorine-containing pyrazolecarboxylic acid derivative.Type: GrantFiled: February 13, 2008Date of Patent: February 8, 2011Assignee: Mitsui Chemicals Agro, Inc.Inventors: Hideki Umetani, Takeshi Kakimoto, Yoji Aoki
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Publication number: 20110028734Abstract: Processes are provided for combining nonsubstituted hydrazine (N2H4), a strong acid, alcohol, and tetraalkoxypropane to produce N-alkylpyrazole.Type: ApplicationFiled: April 16, 2009Publication date: February 3, 2011Applicant: ALBEMARLE CORPORATIONInventors: John E. Chubb, John J. Pascavage
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Patent number: 7879761Abstract: The present invention relates to heteroaroyl-substituted serineamides of the formula I in which the variables A and R1 to R6 are as defined in the description, and to their agriculturally useful salts, to processes and intermediates for their preparation, and to the use of these compounds or of the compositions comprising these compounds for controlling unwanted plants.Type: GrantFiled: March 29, 2006Date of Patent: February 1, 2011Assignee: BASF AktiengesellschaftInventors: Matthias Witschel, Cyrill Zagar, Eike Hupe, Toralf Kühn, William Karl Moberg, Liliana Parra Rapado, Frank Stelzer, Andrea Vescovi, Michael Rack, Robert Reinhard, Bernd Sievernich, Klaus Groβmann, Thomas Ehrhardt
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Patent number: 7875646Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.Type: GrantFiled: September 21, 2007Date of Patent: January 25, 2011Assignee: Sanofi-AventisInventors: Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
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Patent number: 7875618Abstract: The invention relates to imidazo[1,5-a]quinoxaline derivatives having Formula IIa: to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans.Type: GrantFiled: November 25, 2008Date of Patent: January 25, 2011Assignees: Wyeth, elbion GmbHInventors: Michael S. Malamas, Yike Ni, James Joseph Erdei, Norbert Höfgen, Hans Stange, Rudolf Schindler, Ute Egerland, Barbara Langen
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Patent number: 7872006Abstract: The present invention relates to a pyrazole compound having potent CB1-antagonizing activity, having the following formula [I]: wherein R1 and R2 are the same or different and an optionally substituted aryl group etc., R3 is an alkyl group etc., E is one of the following groups of the formula (i) to (iv): Q1 is a single bond, an alkylene group or a group of the formula: —N(R7)—, R7 is a hydrogen atom or an alkyl group, Q2 is a single bond, an oxygen atom or an alkylene group, R4 is a cycloalkyl group, a group of the formula: —N(R5)(R6) etc., one of R5 and R6 is a hydrogen atom or an alkyl group and the other is an alkyl group, a group of the formula: —N(R8)(R9) etc., D is an oxygen atom etc., RA1 is an amino group etc., RA2 is an optionally substituted aliphatic heterocyclic group, R is an alkyl group optionally substituted by one to three halogen atom(s) etc., one of R8 and R9 is a hydrogen atom or an alkyl group and the other is an alkyl group etc., or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 20, 2006Date of Patent: January 18, 2011Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Yasunori Moritani, Ritsuo Imashiro, Atsushi Sato
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Patent number: 7863310Abstract: The present invention provides kinase inhibitors of Formula I:Type: GrantFiled: January 21, 2005Date of Patent: January 4, 2011Assignee: Eli Lilly and CompanyInventors: Rosanne Bonjouklian, Robert Dean Dally, Alfonso de Dios, Mirian Filadelfa del Prado Catalina, Carmen Dominguez-Fernandez, Carlos Jaramillo Aguado, Beatriz Lopez de Uralde-Garmendia, Timothy Alan Shepherd
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Publication number: 20100331381Abstract: The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.Type: ApplicationFiled: May 6, 2010Publication date: December 30, 2010Applicant: Gruenenthal GmbHInventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim
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Patent number: 7846960Abstract: Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.Type: GrantFiled: May 22, 2007Date of Patent: December 7, 2010Assignee: Eli Lilly and CompanyInventors: Michael Gregory Bell, Robert Anthony Doti, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Peter Rudolph Manninen, Jason Matthew Ochoada, Fucheng Qu, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M. Warshawsky
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Patent number: 7846949Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).Type: GrantFiled: February 11, 2005Date of Patent: December 7, 2010Assignee: IRM LLCInventors: Valentina Molteni, Xiaolin Li, Fang Liang, Juliet Nabakka, Enrique Saez, John Wityak
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Patent number: 7829586Abstract: Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted with a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.Type: GrantFiled: September 28, 2006Date of Patent: November 9, 2010Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Hirokatsu Ito, Kensuke Kobayashi, Hisashi Ohta, Osamu Okamoto, Satoshi Ozaki, Tomohiro Tsujita
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Patent number: 7816562Abstract: The invention is amido-borate compounds containing one or more anionic amido-borate moieties comprising an organoborate anion wherein the boron atom is bonded to a nitrogen atom of ammonia or an organic compound containing one or more nitrogen atoms, such as a hydrocarbyl amine, a hydrocarbyl polyamine, or an aromatic heterocycle containing one or more nitrogen atoms, and a cationic counter ion.Type: GrantFiled: October 6, 2006Date of Patent: October 19, 2010Assignee: Dow Global Technologies Inc.Inventors: Shaoguang Feng, Gary L. Jialanella, Peter Nickias, Toni Ristoski
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Patent number: 7816558Abstract: Provided is a triarylcarboxylic acid derivative, or an isomer, a prodrug, a hydrate, a solvate, a polymorph, or a pharmaceutically acceptable salt thereof, represented by the following general formula (I): wherein A is an optionally substituted aryl or heteroaryl, and B is an optionally substituted monocyclic heteroaryl; and a pharmaceutical composition comprising the same and a pharmaceutically acceptable carrier. The triarylcarboxylic acid derivative (I) exhibits potent xanthine oxidase inhibiting action and is therefore useful as a therapeutic agent for preventing or treating hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy and diabetic retinopathy.Type: GrantFiled: October 6, 2006Date of Patent: October 19, 2010Assignee: Astellas Pharma Inc.Inventors: Junji Sato, Kazuyuki Hattori, Hirokazu Kubota, Ryosuke Munakata, Toru Asano, Junko Maeda, Masakatsu Kawakami, Akio Kamikawa
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Publication number: 20100261900Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.Type: ApplicationFiled: December 23, 2009Publication date: October 14, 2010Applicant: sanofi-aventisInventors: Omar RKYEK, Marc NAZARE, Andreas LINDENSCHMIDT, Jorge ALONSO, Matthias URMANN, Nis HALLAND
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Publication number: 20100256390Abstract: The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal? are independently Cl or F, and R1 is H, Cl or F.Type: ApplicationFiled: June 16, 2008Publication date: October 7, 2010Applicants: SYNGENTA CROP PROTECTION, INC., SYNGENTA LIMITEDInventors: Martin Charles Bowden, Brian David Gott, David Anthony Jackson
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Patent number: 7803953Abstract: To provide a process for preparing an arylamine highly selectively and highly efficiently, which is also industrially superior without a fear of a side reaction when a strong base is employed. An aryl compound having an active group is reacted with an amine compound in the presence of a base by means of a catalyst for producing an arylamine which comprises a palladium compound having a tertiary phosphine group and a phase-transfer catalyst.Type: GrantFiled: June 1, 2007Date of Patent: September 28, 2010Assignee: Tosoh CorporationInventors: Takanori Miyazaki, Masakazu Nishiyama, Naoki Matsumoto
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Patent number: 7795294Abstract: This invention is directed to a tetrahydro-2H-indazole pyrazole cannabinoid modulator compound of formula (I): or a form thereof, wherein p, R1, R2 and Ar are as herein described and * represents a chiral center, and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.Type: GrantFiled: February 13, 2007Date of Patent: September 14, 2010Assignee: Janssen Pharmaceutica N.V.Inventors: Fina Liotta, Huajun Lu, Michael P. Wachter, Mingde Xia
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Patent number: 7772246Abstract: The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.Type: GrantFiled: July 30, 2008Date of Patent: August 10, 2010Assignee: Pfizer Inc.Inventors: Jingrong Jean Cui, Judith Gail Deal, Danlin Gu, Chuangxing Guo, Mary Catherine Johnson, Robert Steven Kania, Susan Elizabeth Kephart, Maria Angelica Linton, Indrawan James McAlpine, Mason Alan Pairish, Cynthia Louise Palmer
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Publication number: 20100197753Abstract: The invention relates to novel aromatic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, b their use as medicaments and to medicaments comprising them.Type: ApplicationFiled: May 20, 2008Publication date: August 5, 2010Inventors: Henri Mattes, Joachim Nozulak, David Orain, Kumlesh K. Dev
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Patent number: 7763629Abstract: The present invention relates to compounds useful as inhibitors of protein kinase, represented by Structural Formula (I): wherein the variables in Structural Formula (I) are as described herein. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.Type: GrantFiled: April 12, 2007Date of Patent: July 27, 2010Assignee: Vertex Pharmaceuticals IncorporatedInventors: Jean-Damien Charrier, David Kay, Ronald Knegtel
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Publication number: 20100184815Abstract: Disclosed are compounds of the formula: And pharmaceutically acceptable salts thereof, wherein the variables are as defined herein, which are useful in activating PPAR? and in treating atherosclerosis hypercholesterolemia, primary hypercholesterolemia or mixed dyslipidemia, hypertriglyceridemia, Frederickson Types IV and V hyperlipidemia. Pharmaceutical compositions, intermediates useful in the preparation of the compounds of formula I and methods of making the compounds of formula I are also disclosed.Type: ApplicationFiled: December 18, 2009Publication date: July 22, 2010Inventors: Gary W. Luehr, Arathi Sundaram, Priya Jaishankar, Chhaya Bhakta, Pascal Druzgala
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Patent number: 7759381Abstract: Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R8 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.Type: GrantFiled: July 3, 2007Date of Patent: July 20, 2010Assignee: Aventis AgricultureInventors: Hyoung Ik Lee, Loïc Patrick Le Hir de Fallois, Philip Reid Timmons, William Glenn Cawthorne, Jr., Adalberto Perez de Leon
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Publication number: 20100179203Abstract: This invention relates to novel pyrazole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.Type: ApplicationFiled: June 27, 2008Publication date: July 15, 2010Inventors: Antonio Nardi, Jeppe Kejser Christensen, David Spencer Jones
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Patent number: 7754751Abstract: A method for preferentially inhibiting release of pro-inflammatory cytokines over release of anti-inflammatory cytokines using a fused pyrazolyl compound of formula (I): A is R or in which R is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is R?, nitro, halogen, —C(O)—OR?, —C(O)—SR?, —C(O)—NR?R?, —(CH2)mOR?, —(CH2)mSR?, —(CH2)mNR?R?, —(CH2)mCN, —(CH2)mC(O)—OR?, —(CH2)mC(O)H, or R1 and R2 together, R3 and R4 together, or R5 and R6 together are —O(CH2)nO—, in which each of R? and R?, independently, is H, alkyl, cyclyl, aryl, heteroaryl, heterocyclyl; and m is 0, 1, 2, 3, 4, 5, or 6; and n is 1, 2, or 3. This invention also covers a method of inhibiting activity of NF-?B with such a compound.Type: GrantFiled: March 15, 2005Date of Patent: July 13, 2010Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Che-Ming Teng, Jih-Hwa Guh, Shiow-Lin Pan, Sheng-Chu Kuo, Fang-Yu Lee
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Publication number: 20100174094Abstract: The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.Type: ApplicationFiled: May 30, 2008Publication date: July 8, 2010Applicant: BASF SEInventors: Thomas Zierke, Joachim Rheinheimer, Michael Rack, Sebastian Peer Smidt, Ansgar Gereon Altenhoff, Joachim Schmidt-Leithoff, Nina Challand
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Patent number: 7745491Abstract: Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.Type: GrantFiled: August 9, 2005Date of Patent: June 29, 2010Assignee: Prosidion LimitedInventors: Matthew Colin Thor Fyfe, Vilasben Kanji Shah
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Patent number: 7745477Abstract: Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.Type: GrantFiled: January 25, 2007Date of Patent: June 29, 2010Assignee: Hoffman-La Roche Inc.Inventors: Aurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
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Patent number: 7737156Abstract: The invention relates to the use of selective phosphodiesterase 9A (PDE9A) inhibitors for producing medicaments for improving perception, concentration, cognitive processes, learning and/or memory.Type: GrantFiled: August 11, 2003Date of Patent: June 15, 2010Assignee: Boehringer Ingelheim International GmbHInventors: Frank-Gerhard Böβ, Christina Erb, Martin Hendrix, Marja van Kampen, Frank Wunder
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Patent number: 7737241Abstract: The invention is a system for initiating free radical polymerization comprising: a) in one part, one or more amido-borate compounds containing one or more anionic amido-borate moieties comprising an organoborate wherein the boron atom is bonded to a nitrogen atom of ammonia or an organic compound containing one or more nitrogen atoms, such as a hydrocarbyl amine, a hydrocarbyl polyamine, or an aromatic heterocycle containing one or more nitrogen atoms and optionally containing one or more heteroatoms or heteroatom containing functional moieties, and one or more cationic counter ions and b) in a second part, a liberating compound which reacts with the nitrogen atom(s) bound to the boron atom(s) upon contact with the amido-borate to form an organoborane radical.Type: GrantFiled: October 6, 2006Date of Patent: June 15, 2010Assignee: Dow Global Technologies Inc.Inventors: Shaoguang Feng, Gary L. Jialanella, Peter Nickias, Toni Ristoski
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Publication number: 20100130743Abstract: Novel benzenedicarboxamides of the formula (I) wherein X represents hydrogen, halogen atom, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl, R1 represents C1-6alkyl, C1-6alkylthio-C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl or C1-6 alkylsulfonyl-C1-6alkyl, Y represents halogen or C1-6alkyl, m represents 0 or 1, A represents O, S, SO, SO2, CH2 or CH(CH3), and Q represents a 5- or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted; processes for their preparation, their intermediates and their use as insecticides.Type: ApplicationFiled: January 27, 2010Publication date: May 27, 2010Applicant: BAYER CROPSCIENCE AGInventors: Katsuaki Wada, Takuya Gombuchi, Yasushi Yoneta, Yuichi Otsu, Katsuhiko Shibuya, Norihiko Nakakura, Rüdiger Fischer, Tetsuya Murata, Eiichi Shimojo
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Patent number: 7714319Abstract: A thin film transistor comprising at least three terminals consisting of a gate electrode, a source electrode and a drain electrode; an insulating layer and an organic semiconductor layer on a substrate, which controls its electric current flowing between the source and the drain by applying a electric voltage across the gate electrode, wherein the organic semiconductor layer comprises a heterocyclic compound containing a nitrogen atom formed by condensation between five member rings each having a nitrogen atom at their condensation sites or between a five member ring and a six member ring each having a nitrogen atom at their condensation sites. The transistor became to have a fast response speed (driving speed), and further, achieved a large on/off ratio getting an enhanced performance as a transistor.Type: GrantFiled: October 27, 2004Date of Patent: May 11, 2010Assignee: Idemitsu Kosan Co., Ltd.Inventors: Hiroaki Nakamura, Hiroshi Yamamoto
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Patent number: 7709654Abstract: Process for the preparation of oxazole, imidazole, and pyraxole boryl compounds. The compounds are intermediates to functionalized compounds, both natural and synthetic which are cytotoxic, anticancer and antiviral agents.Type: GrantFiled: September 11, 2007Date of Patent: May 4, 2010Assignee: Board of Trustees of Michigan State UniversityInventors: Milton R. Smith, III, Robert E. Maleczka, Jr., Venkata A. Kallepalli, Edith Onyeozili
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Patent number: 7691841Abstract: Compounds of formula I in free or salt form, wherein Ar, X, Y and T have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3, particularly an inflammatory or allergic condition such as an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.Type: GrantFiled: August 9, 2005Date of Patent: April 6, 2010Assignee: Novartis AGInventor: Darren M Legrand