One Double Bond Between Ring Memebers Of The Diazole Ring (i.e., Pyrazoline) Patents (Class 548/379.1)
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Patent number: 8957102Abstract: Provided are novel heterocyclic compounds useful as anti-cancer drugs by suppressing protein kinase activities of growth factor receptors such as c-Met, pharmaceutical compositions containing the same, and methods for using the compound.Type: GrantFiled: August 28, 2009Date of Patent: February 17, 2015Assignee: Neopharm Co., Ltd.Inventors: Tae-Seong Kim, Eunkyung Lee, Doyoung Kim, Bu-mahn Park, Jiyeon Park, JungJe Joo
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Patent number: 8901108Abstract: This invention concerns arylsulfonyl pyrazoline carboxamidine derivatives as antagonists of 5-ht6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis.Type: GrantFiled: September 11, 2013Date of Patent: December 2, 2014Assignee: AbbVie Bahamas LimitedInventors: Arnold Van Loevezijn, Wouter I. Iwema Bakker, Axel Stoit, Agatha A. M. Rensink, Jennifer Venhorst, Martina A. W. Van Der Neut, Martin De Hann, Cornelis G. Kruse
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Patent number: 8853252Abstract: The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, hepatic disorders, and/or cardiometabolic disorders.Type: GrantFiled: March 7, 2012Date of Patent: October 7, 2014Assignee: Jenrin Discovery, Inc.Inventors: John F. McElroy, Robert J. Chorvat
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Publication number: 20140011775Abstract: This invention concerns arylsulfonyl pyrazoline carboxamidine derivatives as antagonists of 5-ht6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis.Type: ApplicationFiled: September 11, 2013Publication date: January 9, 2014Applicant: Abbott Healthcare Products B.V.Inventors: Arnold van Loevezijn, Wouter I. Iwema Bakker, Axel Stoit, Agatha A.M. Rensink, Jennifer Venhorst, Martina A.W. Van Der Neut, Martin De Hann, Cornelis G. Kruse
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Patent number: 8476458Abstract: The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.Type: GrantFiled: June 19, 2008Date of Patent: July 2, 2013Assignees: The Wistar Institute, The John Hopkins UniversityInventors: Ronen Marmorstein, Xin Liu, Philip A. Cole, Ling Wang, Erin M. Bowers, David J. Meyers, Chandrani Mukherjee
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Patent number: 8410135Abstract: The invention is directed to 4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor modulators, to pharmaceutical compositions comprising these compounds, to methods for their syntheses, to methods for preparing novel intermediates useful for their syntheses, and to methods for preparing compositions. The invention also relates to the uses of compounds and compositions administered to patients to achieve a therapeutic effect in multiple sclerosis, traumatic brain injury, pain including chronic pain, neuropathic pain, acute pain and inflammatory pain, osteoporosis, appetite disorders, epilepsy, Alzheimer's disease, Tourette's syndrome, cerebral ischaemia, emesis, nausea, and gastrointestinal disorders. Compounds of the present disclosure are directed to formula (I): wherein the substituents have the definitions given in the specification.Type: GrantFiled: June 11, 2008Date of Patent: April 2, 2013Assignee: Solvay Pharmaceuticals B.V.Inventors: Josephus H. M. Lange, Hendrik C. Wals, Bernard J. Van Vliet, Mahmut Yildirim
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Patent number: 8329703Abstract: Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.Type: GrantFiled: February 15, 2005Date of Patent: December 11, 2012Assignee: XTL Biopharmaceuticals Ltd.Inventors: Youhong Hu, Bin Xu, Yun Liao, Kenneth Nawoschik, Yixin Liu, Anthony Sandrasagra, Reza Fathi, Zhen Yang
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Patent number: 8138216Abstract: The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, hepatic disorders, and/or cardiometabolic disorders.Type: GrantFiled: December 31, 2009Date of Patent: March 20, 2012Assignee: Jenrin Discovery, Inc.Inventors: John F. McElroy, Robert J. Chorvat
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Patent number: 8101749Abstract: The invention relates to a method for producing onium salts with tetrafluoroborate anion by reacting an onium halide with an oxonium tetrafluoroborate, sulfonium tetrafluoroborate, or triphenylcarbonium tetrafluoroborate.Type: GrantFiled: November 18, 2005Date of Patent: January 24, 2012Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Andriy Kucheryna, Helge Willner
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Publication number: 20110230488Abstract: The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesised and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.Type: ApplicationFiled: November 25, 2009Publication date: September 22, 2011Applicant: TRT PHARMA INC.Inventors: Jian Hui Wu, Gerald Batist, Jinming Zhou, Guoyan Geng, Rongtuan Lin
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Patent number: 8003626Abstract: Compounds of the formula I in which the substituents are as defined in claim 1 are suitable for use as microbiocides.Type: GrantFiled: July 17, 2006Date of Patent: August 23, 2011Assignee: Syngenta Crop Protection, Inc.Inventors: Clemens Lamberth, Camilla Corsi, Josef Ehrenfreund, Hans Tobler, Harald Walter
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Patent number: 7998996Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animal.Type: GrantFiled: February 14, 2005Date of Patent: August 16, 2011Assignee: Laboratorios del Dr. Esteve S.A.Inventors: Rosa Cuberes Altisen, Bonifacio Gutierrez Silva, Jordi Frigola-Constansa
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Patent number: 7968582Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.Type: GrantFiled: July 14, 2006Date of Patent: June 28, 2011Assignee: Laborotorios Del Dr. Esteve, S.A.Inventor: Rosa Cuberes
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Publication number: 20100222580Abstract: The invention relates to a process for the preparation of onium alkylsulfates by reaction of an onium halide with a symmetrically substituted dialkyl sulfate, in which the alkyl group can have 1 to 14 C atoms, with an asymmetrically substituted dialkyl sulfate, in which one alkyl group can have 4 to 20 C atoms and the second alkyl group denotes methyl or ethyl, with an alkyl trialkylsilyl sulfate, with an alkyl acyl sulfate or with an alkyl sulfonyl sulfate, where the reaction with a dialkyl sulfate is carried out at room temperature.Type: ApplicationFiled: November 18, 2005Publication date: September 2, 2010Applicant: MERCK PATENT GMBHInventors: Nikolai Ignatyev, Urs Welz-Biermann, Andriy Kucheryna, Helge Willner
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Patent number: 7718687Abstract: The present invention relates to prodrugs of dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.Type: GrantFiled: June 27, 2005Date of Patent: May 18, 2010Assignee: Merck Sharp & Dohme Corp.,Inventors: Paul J. Coleman, Christopher D. Cox, George D. Hartman
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Patent number: 7705160Abstract: This invention relates to a method for preparing a 3-halo-4,5-dihydro-1H-pyrazole compound of Formula I comprising contacting with HX1 a different 4,5-dihydro-1H-pyrazole compound of Formula II wherein X1 is halogen and L, R, k and X2 are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein X1, R3, R6, R7, R8a, R8b and n are as defined in the disclosure.Type: GrantFiled: December 21, 2007Date of Patent: April 27, 2010Assignee: E.I. du Pont de Nemours and CompanyInventor: Gary David Annis
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Patent number: 7655685Abstract: The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, hepatic disorders, and/or cardiometabolic disorders.Type: GrantFiled: October 31, 2008Date of Patent: February 2, 2010Assignee: Jenrin Discovery, Inc.Inventors: John F. McElroy, Robert J. Chorvat
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Patent number: 7629373Abstract: The present invention relates to fluorinated dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.Type: GrantFiled: April 3, 2006Date of Patent: December 8, 2009Assignee: Merck & Co. Inc.Inventors: Paul J. Coleman, Christopher D. Cox
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Patent number: 7504519Abstract: The invention relates to derivatives of general formula (I), and to their pharmaceutically acceptable salts, their stereoisomeric forms, preferably their pure enantiomeric or diastereomeric forms and their racemic forms, or a mixture thereof in any mixture ratio, and their N-oxides and the corresponding solvates or hydrates, to the processes for obtaining said derivatives and to the pharmaceutical compositions which contain them. Said derivatives are useful as anti-inflammatory and analgesic agents.Type: GrantFiled: September 22, 2004Date of Patent: March 17, 2009Assignee: Laboratorios Del Dr. Esteve, S.A.Inventors: Rosa Cuberes Altisen, Jorg Holenz, Mario Colombo PiƱol, Mercedes Port De Pol
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Patent number: 7335780Abstract: This invention relates to a method for preparing 3-halo-4,5-dihydro-1H-pyrazole compound of Formula (I), comprising contacting with HX1 a different 4,5-dihydro-1H-pyrazole compound of Formula (II), wherein X1 is halogen and L, R, k and X2 are as defined in the disclosure.Type: GrantFiled: July 29, 2003Date of Patent: February 26, 2008Assignee: E.I. du Pont de Nemours and CompanyInventor: Gary David Annis
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Patent number: 6852750Abstract: New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-? activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.Type: GrantFiled: June 21, 2002Date of Patent: February 8, 2005Assignee: Guilford Pharmaceuticals, Inc.Inventors: Paul F. Jackson, Takashi Tsukamoto, Barbara S. Slusher, Eric Wang
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Patent number: 6831075Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.Type: GrantFiled: August 22, 2002Date of Patent: December 14, 2004Assignee: Cephalon, Inc.Inventors: Jasbir Singh, Rabindranath Tripathy
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Patent number: 6774229Abstract: The invention relates to a process for the preparation of heterocycles, characterised in that the following components: i) a propargyl derivative of the general structural formula I a wherein Het is an optionally substituted hetero atom and A is a substituted or unsubstituted aromatic entity, a substituted or unsubstituted aromatic heterocycle, a substituted or unsubstituted vinyl arene and/or a derivative thereof, an olefin, an alkyne, an acceptor group or a nitrile; (ii) a compound of the general structural formula II, B—X II, wherein B is an electron-deficient substituted or unsubstituted aromatic entity with or without an acceptor group, an electron-deficient substituted or unsubstituted heteroaromatic entity with or without an acceptor group, an electron-deficient olefin and/or alkyne, a metal complex, and X is a leaving group; (iii) a nucleophile of the general structural formula III, Y—Cn—Z III, wherein Y and/or Z, eachType: GrantFiled: May 20, 2002Date of Patent: August 10, 2004Assignee: Morphochem AGInventors: Thomas Mueller, Markus Ansorge
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Patent number: 6689770Abstract: The present application describes aryl sulfonyls of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa inhibitors.Type: GrantFiled: February 12, 2002Date of Patent: February 10, 2004Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Ruth R. Wexler, Irina C. Jacobson
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Publication number: 20030203975Abstract: A compound is provided having the formula: 1Type: ApplicationFiled: December 18, 2000Publication date: October 30, 2003Inventors: David John Mincher, Agnes Turnbull
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Publication number: 20030186803Abstract: A process for the preparation of imidazolium carbenes of formula (I) wherein R1 and R2 which can be the same or different, are hydrogen or linear or branched hydrocarbyl groups comprising heating an imidazolium halide with a strong base under reduced pressure and separating the resultant products is described.Type: ApplicationFiled: February 24, 2003Publication date: October 2, 2003Inventors: John Martyn Earle, Richard Kenneth Seddon
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Patent number: 6617342Abstract: This invention provides compounds and their pharmaceutically acceptable salts, pharmaceutical formulation of said compounds and methods for treating hyperglycemia associated with non-insulin dependant diabetes and for treating hyperlipidemia.Type: GrantFiled: April 16, 2002Date of Patent: September 9, 2003Assignee: Eli Lilly and CompanyInventor: Samuel James Dominianni
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Patent number: 6455525Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.Type: GrantFiled: October 31, 2000Date of Patent: September 24, 2002Assignee: Cephalon, Inc.Inventors: Jasbir Singh, Rabindranath Tripathy
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Patent number: 6376519Abstract: Compounds of the formula wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula II: wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.Type: GrantFiled: June 16, 2000Date of Patent: April 23, 2002Assignee: Temple University-of the Commonwealth of Higher EducationInventors: E. Premkumar Reddy, M. V. Ramana Reddy
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Patent number: 6242609Abstract: A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of a four equivalent coupler using a halogenating agent, wherein said halogenating agent is said ammonium trihalide.Type: GrantFiled: April 7, 1999Date of Patent: June 5, 2001Assignee: Konica CorporationInventor: Fumio Ishii
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Patent number: RE39681Abstract: Compounds of the formula wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula II: wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.Type: GrantFiled: July 29, 2003Date of Patent: June 5, 2007Assignee: Temple University - of the Commonwealth System of Higher EducationInventors: E. Premkumar Reddy, M. V. Ramana Reddy