Heavy Metal Or Aluminum Containing Patents (Class 548/402)
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Publication number: 20020038036Abstract: An organometallic compound obtainable by contactingType: ApplicationFiled: February 22, 2001Publication date: March 28, 2002Inventors: Luigi Resconi, Simona Guidotti
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Patent number: 6348611Abstract: The present invention relates to a process for carbonylation of epoxide derivatives, in which the reactivity, selectivity and the yield are superior. More specifically, the present invention relates to a process for hydroformylation of an epoxide derivative in which there is utilized a transition metal catalyst having a cyclopentadienyl radical, thereby improving the reactivity and selectivity. Further, the present invention relates to a process for hydroesterification of an epoxide derivative, in which a proper catalyst is selected, and the reaction temperature and pressure are adjusted within proper ranges under the presence of a cobalt catalyst, thereby improving the product selectivity and the yield.Type: GrantFiled: August 25, 1999Date of Patent: February 19, 2002Assignee: Samsung Electronic Co., Ktd.Inventors: Byeong-No Lee, Duck-Joo Yang, Young-Hun Byun
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Publication number: 20020010085Abstract: Bicyclic amino alcohols, whose amino group and hydroxy group are bonded in positions 1,3 adjacent to the bridge, for example 1Type: ApplicationFiled: March 6, 2001Publication date: January 24, 2002Inventor: Peter Herold
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Patent number: 6331537Abstract: This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.Type: GrantFiled: December 2, 1999Date of Patent: December 18, 2001Assignee: GPI Nil Holdings, Inc.Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
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Patent number: 6313333Abstract: The present invention relates to tetra- and penta-nuclear platinum complexes with antitumor activity, to a method for preparing them and to pharmaceutical compositions containing them.Type: GrantFiled: April 27, 2000Date of Patent: November 6, 2001Assignee: Setanta Therapeutics, Inc.Inventors: Giovanni Da Re, Roberto Di Domenico, Silvano Spinelli, Nicholas Farrell
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Publication number: 20010019782Abstract: A light-emitting material comprises a compound having a partial structure represented by the following formula (1) or tautomer thereof: 1Type: ApplicationFiled: December 27, 2000Publication date: September 6, 2001Inventors: Tatsuya Igarashi, Keizo Kimura, Kazumi Nii
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Patent number: 6191284Abstract: A ferroceneylphosphine ligand and complexes prepared therefrom for homogeneous catalytic enantioselective hydrogenation, the ligand having the formula (I): Another aspect of the invention is directed to a ferroceneylphosphine ligand of formula (II),Type: GrantFiled: December 20, 1999Date of Patent: February 20, 2001Assignee: Degussa-Huels AktiengesellschaftInventors: Paul Knochel, Tanja Ireland, Gabriele Grossheimann, Karlheinz Drauz, Ingo Klement
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Patent number: 6177563Abstract: Fluoroaluminate compounds of formula M+n(AlF4)n− wherein n is 1 to 3 and M+n is N(R2)4, P(R2)4, As(R2)4, HN(R2)3, H2N(R2)2, H3N(R2), (R2)3P═N═P(R2)3, S[N(R2)2]3, (R2)NCN(R)2, (R)2N—(C(R)2)k—N(R)3, and ZHm+m wherein Z is a base capable of accepting m protons, and various cyclic and aryl groups are disclosed as well as processes for their preparation.Type: GrantFiled: July 2, 1999Date of Patent: January 23, 2001Assignee: E. I. du Pont de Nemours and CompanyInventors: Richard Leslie Harlow, Norman Herron, David Lincoln Thorn
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Patent number: 6153776Abstract: Group 3-6 or Lanthanide metal complexes possessing two metal centers, catalysts derived therefrom by combining the same with strong Lewis acids, Bronsted acid salts, salts containing a cationic oxidizing agent or subjected to bulk electrolysis in the presence of compatible, inert non-coordinating anions and the use of such catalysts for polymerizing olefins, diolefins and/or acetylenically unsaturated monomers are disclosed.Type: GrantFiled: August 28, 1998Date of Patent: November 28, 2000Assignee: The Dow ChemicalInventors: Jasson T. Patton, Tobin J. Marks, Liting Li
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Patent number: 6146615Abstract: A compound of formula (I): ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R.sup.1, R.sup.2 and R.sup.3, R.sup.4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.Type: GrantFiled: January 11, 1999Date of Patent: November 14, 2000Assignees: The University of Toledo, Schering AktiengesellschaftInventors: Julian A. Davies, Wolfgang Ebert, Bernd Raduechel
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Patent number: 6143357Abstract: Organometallic compounds useful for forming aluminum films by chemical vapor deposition are disclosed. Also disclosed are methods of preparing the organimetallic compounds and methods of forming aluminum films.Type: GrantFiled: March 22, 1999Date of Patent: November 7, 2000Assignee: Rohm and Haas CompanyInventors: Hyun-Koock Shin, Hyun-Joo Shin
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Patent number: 6133495Abstract: A process for producing an .alpha.-olefin oligomer, comprising subjecting an .alpha.-olefin to oligomerization in a reaction solution containing a chromium-based catalyst produced by bringing at least a chromium compound (a), a pyrrole ring-containing compound (b), an alkyl aluminum compound (c) and a halogen-containing compound (d) into contact with each other, wherein the chromium-based catalyst is a catalyst produced by bringing the pyrrole ring-containing compound (b), the alkyl aluminum compound (c) and the halogen-containing compound (d) into contact with each other in a hydrocarbon and/or halogenated hydrocarbon solvent, and then bringing the resultant mixed solution into contact with the chromium compound (a); or a catalyst produced by bringing the chromium compound (a), the pyrrole ring-containing compound (b), the alkyl aluminum compound (c) and the halogen-containing compound (d) into contact with each other in a hydrocarbon and/or halogenated hydrocarbon solvent in the absence of .alpha.Type: GrantFiled: January 2, 1998Date of Patent: October 17, 2000Assignee: Mitsubishi Chemical CorporationInventors: Hisao Urata, Takayuki Aoshima, Sugio Nishimura
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Patent number: 6130349Abstract: Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates. Such compositions provide a versatile and low-cost alternative to existing catalysts.Type: GrantFiled: December 15, 1998Date of Patent: October 10, 2000Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Barry M. Trost, Iwao Hachiya
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Patent number: 6121443Abstract: Organometallic precursor compounds useful for forming aluminum films by chemical vapor deposition are disclosed. Also disclosed are methods of preparing the organometallic precursor compounds and methods of forming aluminum films.Type: GrantFiled: March 31, 1999Date of Patent: September 19, 2000Assignee: Rohm and Haas CompanyInventor: Hyun-Koock Shin
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Patent number: 6060606Abstract: An optical recording medium having at least a recording layer and a reflective layer on a substrates, the said recording layer contains a dipyrromethene metal chelate compound obtained from a dipyrromethene compound represented by the general formula (1) and a metal ion: ##STR1## wherein R.sup.1 to R.sup.7 are defined in the specification.Type: GrantFiled: April 14, 1999Date of Patent: May 9, 2000Assignees: Mitsui Chemicals, Inc., Yamamoto Chemicals, Inc.Inventors: Tsutami Misawa, Kenichi Sugimoto, Taizo Nishimoto, Hisashi Tsukahara, Takeshi Tsuda, Keisuke Takuma, Hideki Umehara
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Patent number: 6034258Abstract: Transition metal complexes of the formula IL.sub.m MX.sub.n I,whereL is a ligand of the formula II ##STR1## m is 1 or 2, M is a titanium, zirconium, hafnium, vanadium, niobium, tantalum, or a rare earth metal,X is fluorine, chlorine, bromine, iodine, hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.6 -C.sub.15 -aryl or OR.sup.1,n is 1, 2, 3, or 4 as defined herein, andR.sup.1, R.sup.2, R.sup.3, R.sup.4, and A are as defined herein,and the use of these complexes as catalysts for olefin polymerization are described herein.Type: GrantFiled: April 16, 1997Date of Patent: March 7, 2000Assignee: BASF AktiengesellschaftInventors: Marc Oliver Kristen, Hans-Helmut Gortz, Berth-Jan Deelmann, Michael Franz Lappert, Wing-Por Leung, Hung-Kay Lee
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Patent number: 6022980Abstract: This invention provides an improved process for the preparation and separation of 4-halo and 6-halomelatonins.Type: GrantFiled: May 13, 1999Date of Patent: February 8, 2000Assignee: Eli Lilly and CompanyInventor: Michael Edward Flaugh
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Patent number: 6008378Abstract: The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenical molecules are also featured in the invention.Type: GrantFiled: October 21, 1997Date of Patent: December 28, 1999Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, B. Albert Griffin
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Patent number: 6008393Abstract: Compounds of formulae I: (DIP)IrX.sub.q Y.sub.r (Z), Ia: (DIP)IrX.sub.s Y.sub.t (Z).sub.2 and Ib: (DIP)Ir(Z).sub.3 or mixtures of at least two of those compounds, wherein DIP is a ditertiary diphosphine, the two phosphine groups of which are bonded to a C.sub.2 -, C.sub.3 - or C.sub.4 -carbon chain, with the result that the diphosphine forms a 5- to 7-membered ring together with the Ir atom, X is Cl, Br or I, Y is a hydrogen atom, q and r are 0, 1 or 2 and the sum of q+r is 2, s and t are 0 or 1 and the sum of s+t is 1, and Z is the anion of an organic oxy acid that contains a group C(.dbd.O), S(.dbd.O)O or P(.dbd.O)O in the anion. The compounds are excellent catalysts for the hydrogenation of imines, especially for the enantioselective hydrogenation of prochiral imines.Type: GrantFiled: January 22, 1998Date of Patent: December 28, 1999Assignee: Novartis AGInventors: Rafael Sablong, John Anthony Osborn, Felix Spindler
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Patent number: 6001872Abstract: The present invention relates to the treatment of tumors with a novel water soluble trans-platinum coordination compound having the general structural formula [PtBX.sub.m (NR*.sub.3)] where B is a planar, heterocyclic ring containing at least one nitrogen atom, and a pendant chelating group; and X is an anionic ligand; and R* is hydrogen or a lower alkyl.Type: GrantFiled: March 5, 1999Date of Patent: December 14, 1999Assignee: Virginia Commonwealth UniversityInventors: Nicholas P. Farrell, Ulrich Bierbach
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Patent number: 5990318Abstract: Novel soluble polyester-supported chiral phosphines have been prepared and have been used in the preparation of rhodium and ruthenium catalysts. Such polymer-supported catalysts show high catalytic activities and enantioselectivities. In the case of Ru(BINAP) catalyst supported on soluble polyester, the resulting catalysts were found to be more active than those of the corresponding homogeneous Ru(BINAP) catalysts in the asymmetric hydrogenation of 2-arylpropenoic acids. These soluble polyester-supported catalysts can be easily separated from the reaction mixture and then be reused without loss of activity and selectivity.Type: GrantFiled: March 6, 1998Date of Patent: November 23, 1999Assignee: The Hong Kong Polytechnic UniversityInventors: Albert Sun-Chi Chan, Qing-Hua Fan
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Patent number: 5912207Abstract: Metal chelates of herbicidal dione compounds of the formula ##STR1## are chemically stable for long periods of time under normal as well as extreme temperature conditions. Chemically stable liquid herbicidal formulations containing metal chelates of the herbicidal compounds of formula (I) and water, an organic solvent or a liquid co-herbicide and processes for producing chemically stable herbicidal compositions containing such metal chelates are also described.Type: GrantFiled: January 31, 1997Date of Patent: June 15, 1999Assignee: Zeneca LimitedInventors: Herbert B. Scher, Jinling Chen
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Patent number: 5880301Abstract: The present invention provides a novel optically active bidentate phosphine ligand palladium complex of formula (I) or (II) which can be used for the preparation of optically active .beta.-hydroxyketones: ##STR1## ?wherein Y.sup.- represents an anion pair which may form salt; X represents ##STR2## {wherein R.sup.1 represents hydrogen atom, C.sub.1-6 alkyl group, C.sub.1-6 alkoxyl group, cyano group, nitro group, halogen atom or phenyl group, etc.; m represents 1 or 2; when m is 2, two R.sup.1 s may be same or different}; andA and B each independently represents phenyl group or cyclohexyl group {said phenyl group and cyclohexyl group each is unsubstituted or substituted by R.sup.2 (R.sup.2 has the same meaning as defined in R.sup.1)}).Type: GrantFiled: September 16, 1997Date of Patent: March 9, 1999Assignee: Nissan Chemical Industries, Ltd.Inventors: Masakatsu Shibasaki, Mikiko Sodeoka, Kazuhiko Ohrai
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Patent number: 5863911Abstract: Diarylethylene metallocene derivatives, processes for preparing the same and pharmaceutical compositions which contain the derivatives are disclosed. The compounds of the invention can exhibit anti-tumor activity, and can be particularly useful in the treatment of estrogen-dependent cancers.Type: GrantFiled: August 11, 1997Date of Patent: January 26, 1999Assignee: Modelisation et Mise au Point de Molecules MedicinalesInventors: Gerard Jaouen, Siden Top
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Patent number: 5756760Abstract: A 1-substituted-2-diphenylphosphinonaphthalene represented by formula (I): ##STR1## wherein at least one of R.sup.1, R.sup.2, R.sup.3, and R.sup.4, which may be the same or different, represents a lower alkyl group having 1 to 4 carbon atoms which may be substituted with an alkoxy group, a phenyl group or --OR.sup.6 (wherein R.sup.6 represents a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or an alcohol-protective group), and the rest of them represent a hydrogen atom; A represents a single bond or a methylene group; and R.sup.5 represents a substituted or unsubstituted phenyl group; and a transition metal complex comprising the 1-substituted-2-diphenylphosphinonaphthalene as a ligand. The transition metal complex is useful as a catalyst in asymmetric synthesis.Type: GrantFiled: March 7, 1997Date of Patent: May 26, 1998Assignee: Takasago International CorporationInventors: Sotaro Miyano, Tetsutaro Hattori, Yasuko Komuro, Hidenori Kumobayashi
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Patent number: 5703258Abstract: A flame retardant organic silicon and phosphorus containing compound is produced by reacting a silicon halides compound with an organic phosphorus compound to produce an organic silicon and phosphorus halides compound which is then reacted with an organic compound to produce an organic silicon and phosphorus containing compound. This organic silicon and phosphorus containing compound is incorporated in an otherwise more flammable organic material under reaction conditions and in an amount sufficient to reduce the combustibility of the otherwise more flammable organic material. The organic silicon and phosphorus containing compound may also be utilized as coating agents, adhesives, surfactants, insecticides, hydraulic fluid and other uses.Type: GrantFiled: November 20, 1996Date of Patent: December 30, 1997Inventor: David H. Blount
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Patent number: 5691436Abstract: A mixture of silicon and phosphorus are heated and reacted with halide to produce silicon tetrahalides, silicon-phosphorus halide and phosphorus trihalides compositions. These compositions are reacted with any suitable organic, inorganic-organic and/or inorganic compound to produce novel organic silicon-phosphorus containing compositions. These compositions may be utilized as flame retardants, coating agents, adhesives and many other uses.Type: GrantFiled: December 16, 1996Date of Patent: November 25, 1997Inventor: David H. Blount
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Patent number: 5681953Abstract: Fluoroaluminate compounds of formula M.sup.+n (AlF.sub.4).sub.n.sup.- wherein n is 1 to 3 and M.sup.+n is N(R.sub.2).sub.4, P(R.sub.2).sub.4, As(R.sub.2).sub.4, HN(R.sub.2).sub.3, H.sub.2 N(R.sub.2).sub.2, H.sub.3 N(R.sub.2), (R.sub.2).sub.3 P.dbd.N.dbd.P(R.sub.2).sub.3, S?N(R.sub.2).sub.2 !.sub.3, ##STR1## (R).sub.2 N--(C(R).sub.2).sub.k --N(R).sub.3, and ZH.sub.m.sup.+m wherein Z is a base capable of accepting m protons, and various cyclic and aryl groups are disclosed as well as processes for their preparation.Type: GrantFiled: April 28, 1995Date of Patent: October 28, 1997Assignee: E. I. Du Pont de Nemours and CompanyInventors: Richard Leslie Harlow, Norman Herron, David Lincoln Thorn
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Patent number: 5637730Abstract: A process for making pure sodium enalapril is provided which includes the step of decomplexing essentially pure sodium enalapril-sodium iodide complex to yield essentially pure sodium enalapril.Type: GrantFiled: August 19, 1996Date of Patent: June 10, 1997Assignee: Brantford Chemicals Inc.Inventors: K. S. Keshava Murthy, Andrew Burchat, Gamini Weeratunga
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Patent number: 5624919Abstract: Novel trans-platinum IV complexes which contain heterocycle ligands such as quinoline or isoquinoline, anionic ligands such as halide or sulfate, and which optionally may contain ammonia, or a primary or secondary amine are provided. These complexes have application as pharmaceuticals, in particular as anti-tumor agents.Type: GrantFiled: September 13, 1994Date of Patent: April 29, 1997Assignee: The University of Vermont and State Agricultural CollegeInventor: Nicholas Farrell
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Patent number: 5616750Abstract: A compound of formula (I): ##STR1## n which M is a transition metal ion; A is a counter-ion if required;r, s and t are independently 0 to 3 such that r+s+t is in the range of 1 to 3;R.sup.a, R.sup.b, R.sup.c are each independently hydrogen or CH.sub.2 OR' where R' is hydrogen or an organic group;B and E are independently oxygen, CH.sub.2, NR.sup.d in which R.sup.d is alkyl, hydrogen, alkylcarbonyl, or arylcarbonyl or SO.sub.n where n is 0 or an integer 1 or 2, with the proviso that B and E are not simultaneously CH.sub.2 and that when B is oxygen, NR.sup.d or SO.sub.n, then r cannot be 0, and when E is oxygen, NR.sup.d or SO.sub.n, then t cannot be 0;R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are independently hydrogen, alkyl or alkoxy.Type: GrantFiled: October 6, 1993Date of Patent: April 1, 1997Assignee: SmithKline Beecham plcInventors: David Bell, David Miller, Robin P. Attrill
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Patent number: 5585509Abstract: Metallocene complexes of the general formula I ##STR1## where the substituents Y, M, x, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are as described in the disclosure, and ligand systems of the general formula II ##STR2## as intermediates.Type: GrantFiled: March 1, 1995Date of Patent: December 17, 1996Assignee: BASF AktiengesellschaftInventors: Franz Langhauser, David Fischer, J urgen Kerth, G unther Schweier, Hans-Herbert Brintzinger, Elke Barsties, Werner Roell
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Patent number: 5541342Abstract: A process for separating a selected amino acid (enantiomer) from a mixture of different compounds including other amino acids is disclosed, in which process the mixture is contacted with a polymer material which is composed of cross-linked, amino-acid-based monomer units, said polymer material containing a molecular print of the selected amino acid. In the molecular print there is also bound a diastereomeric complex between the selected amino acid (enantiomer), a divalent metallic ion and the amino-acid-based monomer unit. Also the amino-acid-based monomer unit and a process for preparation thereof, as well as a polymer material composed of the amino-acid-based monomer unit and a process for the preparation thereof are disclosed.Type: GrantFiled: September 12, 1994Date of Patent: July 30, 1996Assignees: Bio-Swede AB, Cultor OyInventors: Pirjo Korhonen, Bj orn Ekberg, Lauri Hietaniemi
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Patent number: 5539124Abstract: Disclosed is an azametallocene polymerization catalyst having the general formula ##STR1## where L is a ligand, or mixture of ligands, each having 4 to 30 carbon atoms and containing at least two fused rings, one of which is a pyrrolyl ring, Cp is a ligand containing a cyclopentadienyl group, B is a Lewis acid, Y is a halogen, alkoxy from C.sub.1 to C.sub.20, siloxy from C.sub.1 to C.sub.20, or mixtures thereof, M is titanium, zirconium, or mixtures thereof, m is 1 to 4, and n is 0 to 2, p is 0 to 2, q is 0 to 1, and m+n+q=4. The catalyst is useful in polymerizing unsaturated olefinic monomers such as ethylene.Type: GrantFiled: December 19, 1994Date of Patent: July 23, 1996Assignee: Occidental Chemical CorporationInventors: Bradley P. Etherton, Sandor Nagy
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Patent number: 5532373Abstract: An aluminate complex represented by formula (I): ##STR1## with the groups in the aluminate complex as defined in the specification, and which is capable of radical generation upon photoexcitation; a photopolymerizable composition comprising an ethylenically unsaturated polymerizable compound and the aluminate complex; and an image-forming material comprising a support, an organoaluminum compound anion represented by formula (I'): ##STR2## with the groups in the organoaluminum compound anion as defined in the specification, and a photobleachable dye; are disclosed.Type: GrantFiled: September 22, 1994Date of Patent: July 2, 1996Assignee: Fuji Photo Film Co., Ltd.Inventors: Hirotaka Matsumoto, Jun Yamaguchi, Naoto Yanagihara, Hisashi Yamamoto
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Patent number: 5506253Abstract: A compound of the general formula ##STR1## or a salt or complex thereof, in which X, Y and Z are all optionally substituted carbon atoms and R is hydrogen, optionally substituted hydrocarbyl or acyl or --COOR.sup.7 and R.sup.7 is hydrocarbyl has anti-microbial properties. Particular examples are compounds in which X is --CH.sub.2 -- or --C(CH.sub.3).sub.2 -- and Y and Z are both --CH.sub.2 -- or X is is --CH.sub.2 -- and Y and Z are carbon atoms of a benzene ring. The zinc complexes have useful properties.Type: GrantFiled: October 21, 1994Date of Patent: April 9, 1996Assignee: Zeneca LimitedInventors: Mark R. James, Gordon A. Thomson
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Patent number: 5502065Abstract: The present invention provides compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof.Type: GrantFiled: September 21, 1994Date of Patent: March 26, 1996Assignee: Pfizer Inc.Inventors: Alan D. Brown, Roger P. Dickinson, Martin J. Wythes
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Patent number: 5496961Abstract: Organosilicon compounds having Si-bonded hydrogen atoms are reacted with organic compounds having aliphatic multiple bonds in the presence of triazene oxide-transition metal complexes. The triazene oxide-transition metal complexes are activated by heating at temperatures of from 50.degree. C. to 250.degree. C. and/or by irradiation with light.Type: GrantFiled: May 10, 1995Date of Patent: March 5, 1996Assignee: Wacker-Chemie GmbHInventors: Jochen Dauth, Josef Wolferseder, Bernward Deubzer
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Patent number: 5466824Abstract: The present invention provides a process for the preparation of a complex of indomethacin and a divalent metal comprising forming a solution by dissolving indomethacin and a salt of said divalent metal in a tertiary amide or cyclic tertiary amide, adding a C.sub.1-4 alkanol or C.sub.3-6 ketone to the solution to precipitate the complex, and separating the precipitated complex from the solution. The present invention also provides a method for the treatment of inflammation or pain in a mammal requiring such treatment, comprising administering to said mammal an anti-inflammatory or analgesically effective amount of a complex of indomethacin and a divalent metal, the complex having the formula [M].sub.2 [indomethacin].sub.4 [S].sub.n, wherein M is the divalent metal, S is a molecule of a tertiary amide or a cyclic tertiary amide, and n is 2 or 3, or of a pharmaceutical composition comprising said complex together with a pharmaceutically acceptable carrier, diluent and/or excipient.Type: GrantFiled: March 24, 1994Date of Patent: November 14, 1995Assignee: Biochemical Veterinary Research Pty. Ltd.Inventors: Hubertus L. Regtop, John R. Biffin
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Patent number: 5434116Abstract: A transition metal organometallic compound comprising a transition metal in any one of group 3A to group 8 of the periodic table and cyclic compounds containing a heteroaom in group 5 or group 5B of the periodic table and having a cyclic structure including a .pi.-bonded portion and composed of said heteroatom and said .pi.-bonded portion, wherein said transition metal has a bond of a .pi.-binding heterocylic ligand, said heteroatom and said .pi.-bonded portion and a catalyst for polymerizing olefin comprising the above organic metal compound and an organic compound.Type: GrantFiled: June 2, 1993Date of Patent: July 18, 1995Assignee: Tosoh CorporationInventors: Makoto Sone, Akihiro Yano
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Patent number: 5426189Abstract: Novel CNS dopamine D-2 receptors, such as the compound 5-iodo-7-N-[(1-ethyl-2-pyrrolidinyl)methyl]carboxamide-2,3-dihydrobenzofur an, are disclosed. These compounds are useful as imaging agents for D-2 receptors in the human brain and exhibit good brain retention and in vivo stability.Type: GrantFiled: May 24, 1994Date of Patent: June 20, 1995Assignee: The Trustees of the University of PennsylvaniaInventors: Hank F. Kung, Raymond Murphy
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Patent number: 5420279Abstract: Microporous crystallized gallium phosphate and its substituted derivatives, characterized by:a) the following approximate general formula:R.sub.r Ga.sub.g P.sub.p X.sub.x O.sub.2 F.sub.f hH.sub.2 Owhere the sum of g, p and x is equal to 1, and whereg is a number from 0.3 to 0.5,p is a number from 0.3 to 0.52,x is a number from 0 to 0.4,r is a number from 0.01 to 0.2,f is a number from 0.01 to 0.2,h varies according to the degree of hydration of the solid, from 0 to 0.5.R is an organic compound selected from the group formed by cyclic amines,X is a heteroatom selected from the group formed by the elements: Li, Be, Co, Mg, Mn, Zn, Al, B, Cr, Fe, Ge, Si, Ti, As and Vb) an X-ray diffraction diagram shown in Table 1 of the description,and a method of preparing them.Type: GrantFiled: September 9, 1993Date of Patent: May 30, 1995Assignee: Institut Francais du PetroleInventors: Jean-Francois Joly, Adballah Merrouche, Henri Kessler, Jean-Louis Guth
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Patent number: 5409915Abstract: Novel bis(platinum) (IV) complexes coupled via diamine bridging agents are taught as well as methods for their preparation. These complexes are to be used as pharmaceutical agents, e.g., for the treatment of cancer and parasitic diseases.Type: GrantFiled: September 14, 1993Date of Patent: April 25, 1995Assignee: The University of Vermont and State Agricultural CollegeInventors: Nicholas Farrell, Silvano Spinelli, Mariella Valsecchi, Ernesto Menta
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Patent number: 5371259Abstract: Compounds of the formula I are described[R.sup.1 (Fe.sup.II R.sup.2 .sub.a ].sub.q.sup.+an anX.sup.-q (I)in which a is 1 or 2, n is 1 or 2, R.sup.1 is a substituted or unsubstituted .pi.-arene, R.sup.2 is a substituted or unsubstituted .pi.-arene or cyclopentadienyl anion or indenyl anion, q is an integer from 1 to 3, and X is FSO.sup.-.sub.3 or a q-valent anion of an organic sulfonic acid or of a carbocyclic acid; R.sup.1 can also be a polymeric, aromatic ligand. The invetion particularly relates to the compounds of the formula I wherein a is 1 and q is 1 and X.sup.Type: GrantFiled: April 8, 1993Date of Patent: December 6, 1994Assignee: Ciba-Geigy CorporationInventors: Kurt Meier, Roger P.-E. Salvin
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Patent number: 5334728Abstract: Novel CNS dopamine D-2 receptors, such as the compound 5-iodo-7-N-[(1-ethyl-2-pyrrolidinyl)methyl]carboxamide-2,3-dihydrobenzofur an, are disclosed. These compounds are useful as imaging agents for D-2 receptors in the human brain and exhibit good brain retention and in vivo stability.Type: GrantFiled: October 6, 1992Date of Patent: August 2, 1994Assignee: The Trustees of The University of PennsylvaniaInventors: Hank F. Kung, Raymond Murphy
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Patent number: 5326759Abstract: Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.Type: GrantFiled: November 1, 1993Date of Patent: July 5, 1994Assignee: American Cyanamid CompanyInventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee
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Patent number: 5318962Abstract: Water-soluble complexes having the formula: ##STR1## and stereoisomers thereof, where Z.sup.1 and Z.sup.2 are halogens, and X.sup.1 and X.sup.2 are selected from the group consisting of sulfate, phosphate, nitrate, and monocarboxylate, or are jointly dicarboxylate, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.Type: GrantFiled: August 7, 1992Date of Patent: June 7, 1994Assignee: Board of Regents, The University of Texas SystemInventors: Abdul R. Khokhar, Zahid H. Siddik, Robert A. Newman
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Patent number: 5288592Abstract: The object of the invention is to provide a novel compound exhibiting stable photochromism.The invention is directed to a transition metal-spirobenzothiopyran complex of the general formula ##STR1## wherein R.sup.1 for example be C.sub.1-20 alkyl; R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently may mean hydrogen; Y means O or S; M may for example be Cr, and a process for producing the complex.Type: GrantFiled: November 12, 1992Date of Patent: February 22, 1994Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Akira Miyashita
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Patent number: 5274112Abstract: A process is described for preparing the carbanion of the title as its sodium salt with quantitative yields and at a high level of purity, by a two-stage reaction between disodium-tetracyano-ethylene, Lewis acids and water. Metal complexes, prepared from said carbanion, are particularly suited for methods of using the metal complexes as dyes in industrial applications.Type: GrantFiled: July 7, 1992Date of Patent: December 28, 1993Assignee: Consiglio Nazionale Delle RicercheInventors: Alberto Flamini, Nicola Poli
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Patent number: 5256653Abstract: Platinum complexes of the general formula I[(R.sup.1 NH.sub.2).sub.n Pt].sub.q Y.sub.m X.sub.p (I)in which Y is a phosphonic acid ligand, and the preparation thereof, are described. The platinum complexes are suitable as active substances in pharmaceuticals, in particular for controlling cancers.Type: GrantFiled: March 26, 1991Date of Patent: October 26, 1993Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Bernhard Keppler, Helmut Blum