Boron Containing Patents (Class 548/405)
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Publication number: 20140206648Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronate compounds and their use as therapeutic agents.Type: ApplicationFiled: August 30, 2012Publication date: July 24, 2014Applicant: REMPEX PHARMACEUTICALS, INC.Inventors: Raja K. Reddy, Serge Henri Boyer, Maxim Totrov, Scott Hecker
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Patent number: 8778510Abstract: A pyrromethene-boron complex compound represented by the following formula (1); wherein Z1 and Z2 are independently a hydrogen atom, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkoxy group or a substituted or unsubstituted aryloxy group, at least one of Z1 and Z2 is an alkoxy group substituted with a fluorine atom or an aryloxy group substituted with a fluorine atom or a fluoroalkyl group, and Z1 and Z2 may form a ring.Type: GrantFiled: February 25, 2010Date of Patent: July 15, 2014Assignee: Idemitsu Kosan Co., Ltd.Inventors: Fumio Okuda, Kiyoshi Ikeda, Takayasu Sado, Takahiko Ochi, Yoshimitsu Tanabe, Bunji Sawano
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Publication number: 20140194386Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.Type: ApplicationFiled: January 10, 2014Publication date: July 10, 2014Inventors: Christopher J. BURNS, Denis DAIGLE, Bin LIU, Daniel McGARRY, Daniel C. PEVEAR, Robert E. Lee TROUT, Randy W. JACKSON
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Publication number: 20140193849Abstract: There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.Type: ApplicationFiled: January 7, 2014Publication date: July 10, 2014Applicant: Agency for Science, Technology and ResearchInventors: Karthikeyan Narayanan, Andrew Chwee Aun Wan, Jackie Y. Ying, Nandanan Erathodiyil
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Publication number: 20140194387Abstract: The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.Type: ApplicationFiled: January 13, 2014Publication date: July 10, 2014Applicant: Millennium Pharmaceuticals, Inc.Inventors: Paul E. Fleming, Jing Li
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Publication number: 20140193707Abstract: The invention relates to sulfur-containing compounds of the formula I, to their preparation, and to their use as additives in electrochemical or electrooptical devices, more particularly in electrolytes for lithium batteries, lithium ion batteries, double layer capacitors, lithium ion capacitors, solar cells, electrochromic displays, sensors and/or biosensors.Type: ApplicationFiled: August 22, 2012Publication date: July 10, 2014Applicant: BASF SEInventors: Michael Schmidt, Nikolai Ignatyev, Guenter Semrau, Walter Frank, Peter Barthen, Christoph Breitenstein
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Publication number: 20140187791Abstract: To provide a method for producing a wide variety of carbazole derivatives which have a simple and uncomplicated process and in which variations in the yield, purity, etc. of a desired substance which are caused by an aryl group introduced is reduced as much as possible. A method for producing a carbazole derivative represented by General Formula (1) is provided, in which 9-[4-(10-phenyl-9-anthryl)phenyl]-9H-carbazole having an active site at the 3-position of the carbazole skeleton and an aromatic compound having an active site are coupled. In the formula, Ar1 represents an aryl group with 6 to 13 carbon atoms in a ring, and Ar1 may have a substituent.Type: ApplicationFiled: March 7, 2014Publication date: July 3, 2014Applicant: Semiconductor Energy Laboratory Co., Ltd.Inventors: Hiroki Suzuki, Sachiko Kawakami, Nobuharu Ohsawa, Satoshi Seo
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Publication number: 20140186875Abstract: The invention relates to compositions and methods useful in the labeling and identification of changes in protein levels, changes in enzyme activity, and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These optical labeling molecules find utility in a variety of applications, including use in the field of proteomics.Type: ApplicationFiled: December 30, 2013Publication date: July 3, 2014Applicant: Montana State UniversityInventors: Edward Dratz, Paul Grieco
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Publication number: 20140171656Abstract: The invention relates to new compounds containing alkyl-alkoxy-cyano-borate anions, their preparation and their use, in particular as part of electrolyte formulations for electrochemical or optoelectronic devices.Type: ApplicationFiled: July 6, 2012Publication date: June 19, 2014Applicant: MERCK PATENT GMBHInventors: Nikolai (Mykola) Ignatyev, Michael Schulte, Kentaro Kawata, Tomohisa Goto, Jan Sprenger, Maik Finze, Walter Frank
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Publication number: 20140155566Abstract: The invention relates to new compounds containing alkyl/alkenyl-cyano-borate or alkyl/alkenyl-cyano-fluoroborate anions, their preparation and their use, in particular as part of electrolyte formulations for electrochemical or optoelectronic devices.Type: ApplicationFiled: July 6, 2012Publication date: June 5, 2014Applicant: MERCK PATENT GMBHInventors: Nikolai (Mykola) Ignatyen, Michael Schulte, Kentaro Kawata, Tomohisa Goto, Jan Sprenger, Maik Finze, Walter Frank
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Publication number: 20140121129Abstract: The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.Type: ApplicationFiled: June 15, 2012Publication date: May 1, 2014Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPOREInventors: Young-Tae Chang, Marc Vendrell Escobar, Duanting Zhai, Nam-Young Kang, Yogeswari Chandran
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Publication number: 20140117289Abstract: The present invention describes copolymers containing indenocarbazole derivatives having electron- and hole-transporting properties, in particular for use in the interlayer, emission and/or charge-transport layer of electroluminescent devices, and the monomers which are necessary for the preparation of the copolymers. The invention furthermore relates to a process for the preparation of the copolymers according to the invention, and to electronic devices comprising same.Type: ApplicationFiled: May 18, 2012Publication date: May 1, 2014Applicant: Merck Patent GmbHInventors: Junyou Pan, Niels Schulte
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Publication number: 20140121183Abstract: The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.Type: ApplicationFiled: December 20, 2013Publication date: May 1, 2014Applicant: INFINITY PHARMACEUTICALS, INC.Inventors: Julian ADAMS, Mark L. Behnke, Alfredo C. Castro, Catherine A. Evans, Louis Grenier, Michael J. Grogan, Tao Liu, Daniel A. Snyder, Thomas T. Tibbitts
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Publication number: 20140114074Abstract: The invention relates to a process for the preparation of alkali-metal salts with dihydridodicyanoborate anions by reaction of alkali-metal tetrahydridoborates or trihydridocyanoborates with trialkylsilyl cyanide and further reaction thereof in metathesis reactions.Type: ApplicationFiled: May 23, 2012Publication date: April 24, 2014Applicant: MERCK PATENT GmbHInventors: Nikolai (Mykola) Ignatyev, Michael Schulte, Eduard Bernhardt, Vera Bernhardt-Pitchougina, Helge Willner
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Patent number: 8703743Abstract: The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.Type: GrantFiled: July 3, 2013Date of Patent: April 22, 2014Assignee: Millennium Pharmaceuticals, Inc.Inventors: Paul E. Fleming, Jing Li
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Publication number: 20140107341Abstract: The present invention relates to compounds containing hydrido-tricyano-borate anions, their preparation and their use, in particular as part of electrolyte formulations for electrochemical or optoelectronic devices.Type: ApplicationFiled: May 23, 2012Publication date: April 17, 2014Applicant: MERCK PATENT GMBHInventors: Nikolai (Mykola) Ignatyev, Michael Schulte, Kentaro Kawata, Tomohisa Goto, Eduard Bernhardt, Vera Bernhardt-pitchougina, Helge Willner
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Publication number: 20140094615Abstract: Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.Type: ApplicationFiled: April 26, 2012Publication date: April 3, 2014Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Junqi Li, Eric P. Gillis
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Publication number: 20140084260Abstract: In certain embodiments, the invention provides boron-nitrogen heterocycles having Formula (I): wherein one of the E1 and E2 is N, and one of the E1 and E2 is B; wherein E3 and E4 is carbon; wherein ring Y and ring Z are 5-membered or 6-membered carbocyclic or heterocyclic aromatic ring fused to ring X; wherein R2 and R3 represent mono, di, tri, tetra substitutions or no substitution; wherein R2 and R3 are each independently selected from various substituents; and wherein any two adjacent R2, and R3 are optionally joined to form a ring, which may be further substituted. In certain embodiments, the invention provides devices, such as organic light emitting devices, that comprise such boron-nitrogen heterocycles.Type: ApplicationFiled: March 6, 2013Publication date: March 27, 2014Applicant: Universal Display CorporationInventors: Chuanjun Xia, Chun Lin
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Publication number: 20140076403Abstract: The present disclosure generally relates to organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. In addition, the present disclosure relates to methods of making organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. The present disclosure also generally relates to chromophoric compounds that combine strong absorption of light at visible wavelengths with the ability to undergo symmetry-breaking intramolecular charge transfer (ICT), and their use for the generation of free carriers in organic photovoltaic cells (OPVs) and electric-field-stabilized geminate polaron pairs. The present disclosure also relates to the synthesis of such compounds, methods of manufacture, and applications in photovoltaic systems and organic lasers.Type: ApplicationFiled: May 15, 2013Publication date: March 20, 2014Applicants: University of Southern California, The Regents of the University of MichiganInventors: Stephen R. Forrest, Mark E. Thompson, John J. Chen, Jonathan R. Sommer, Peter I. Djurovich, Kathryn R. Allen
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Patent number: 8673957Abstract: A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R5 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.Type: GrantFiled: March 21, 2012Date of Patent: March 18, 2014Assignees: Tetsuo Nagano, Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuo Nagano, Yu Gabe, Yasuteru Urano
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Publication number: 20140073604Abstract: Disclosed are compounds that are conjugates of ladder frame polyether compounds and biologically active compounds or research compounds, pharmaceutical formulations comprising the conjugates, and methods of transporting the conjugates across biological membranes.Type: ApplicationFiled: March 15, 2013Publication date: March 13, 2014Applicant: UNIVERSITY OF NORTH CAROLINA AT WILMINGTONInventor: UNIVERSITY OF NORTH CAROLINA AT WILMINGTON
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Publication number: 20140058115Abstract: A family of three 8-alkyl boron dipyrromethenes 1, 2, and 3 has been prepared. These compounds are characterized by emission in the green region of the electromagnetic radiation spectrum and exhibit an almost double laser efficiency than other commercial dyes and much greater photostability. The 8-alkyl boron dipyrromethenes are prepared by catalytic hydrogenation (reduction) of the corresponding 8-alkenyl boron dipyrromethenes, which are obtained by Liebeskind-Srogl coupling of thiomethylboron dipyrromethene with an alkenyl boronic acid.Type: ApplicationFiled: October 4, 2013Publication date: February 27, 2014Applicant: UNIVERSIDAD DE GUANAJUATOInventors: Eduardo PEÑA CABRERA, Ismael Javier ARROYO CORDOVA, Fabiola Irene LOPEZ VALLEJO
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Publication number: 20140051109Abstract: The present invention relates to compounds of a general formula (I) having photoluminescence properties. The present invention also relates to applications, such as protein imaging tools, involving such compounds.Type: ApplicationFiled: March 1, 2012Publication date: February 20, 2014Applicant: Agency for Science, Technology and ResearchInventors: Young-Tae Chang, Jae-Jung Lee, Sung-Chan Lee
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Publication number: 20140051863Abstract: The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo green, or BODIPY. The sensors find particular use in detecting copper in cells and living animals.Type: ApplicationFiled: March 14, 2013Publication date: February 20, 2014Inventor: The Regents Of The University Of California
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Publication number: 20140038856Abstract: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6.Type: ApplicationFiled: May 8, 2013Publication date: February 6, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kyle GEE, Aleksey RUKAVISHNIKOV, Courtenay HART, Richard HAUGLAND, Wai-Yee LEUNG, Wayne PATTON, Zhenjun DIWU
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Publication number: 20140027685Abstract: The present invention provides a novel boron compound that has a maximum absorption wavelength in the near-infrared light range and has low absorption in the visible ray range, and thus is excellent as a near-infrared absorber, and a near-infrared absorber and a near-infrared absorbing synthetic resin composition using the compound. The present invention specifically provides a boron compound represented by the following general formula (1), preferably a boron compound wherein R1 to R16 in the general formula (1) each represent a hydrogen atom or an alkyl group, and a near-infrared absorbing synthetic resin composition containing the boron compound as a near-infrared absorber. In the above-mentioned general formula (1), R1 to R16 each represent a hydrogen atom, a halogen atom, a nitro group, a cyano group, an amino group, an alkyl group having 1 to 20 carbon atoms optionally having substituents, or the like.Type: ApplicationFiled: April 9, 2012Publication date: January 30, 2014Applicant: ADEKA CORPORATIONInventors: Naoto Ueda, Kazukiyo Nomura
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Publication number: 20140018545Abstract: The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention are improved over those in the prior art by selection of particular classes of sidechains in the P1 and/or P2 position of the inhibitor that contain a carboxylic acid moiety. The compounds of the present invention can have a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.Type: ApplicationFiled: September 24, 2013Publication date: January 16, 2014Applicant: Trustees of Tufts CollegeInventors: William W. Bachovchin, Hung-sen Lai, Wengen Wu
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Publication number: 20140005399Abstract: The invention provides a polycyclic aromatic compound or a salt thereof having a partial structure represented by the following general formula (I): wherein X, ring A, ring B, ring C, and ring D are as defined in the specification.Type: ApplicationFiled: March 9, 2012Publication date: January 2, 2014Applicant: KYOTO UNIVERSITYInventors: Takuji Hatakeyama, Masaharu Nakamura, Sigma Hashimoto
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Publication number: 20140005392Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.Type: ApplicationFiled: August 29, 2013Publication date: January 2, 2014Applicant: SanofiInventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
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Publication number: 20130316943Abstract: Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.Type: ApplicationFiled: February 6, 2012Publication date: November 28, 2013Applicant: REMPEX PHARMACEUTICALS, INC.Inventors: Tomasz Glinka, Robert Higuchi, Scott Hecker, Brian Eastman, Olga Rodny
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Patent number: 8580463Abstract: The present disclosure relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium includes a polymer matrix having one or more polymer chains. The optical storage medium also includes a reverse saturable absorption (RSA) sensitizer disposed within the polymer matrix that is configured to become excited upon exposure to light having an intensity above an intensity threshold and configured to transfer energy to a reactant. The optical storage medium also includes a diphenyl cyclopropene (DPCP)-derivative reactant disposed within the polymer matrix and capable of undergoing a modification upon receiving an energy transfer from the excited sensitizer that changes a refractive index of the optical medium.Type: GrantFiled: November 17, 2011Date of Patent: November 12, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Eugene Pauling Boden, Kwok Pong Chan, Evgenia Mikhailovna Kim
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Patent number: 8580464Abstract: The invention relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium composition includes a polymer matrix. Disposed within the polymer matrix is a reactant capable of undergoing a modification that alters the refractive index of the composition upon receiving an energy transfer from an excited sensitizer. A non-linear sensitizer is also disposed within the polymer matrix, and the sensitizer includes a metal-substituted subphthalocyanine (M-sub-PC) reverse saturable absorber configured to become excited upon exposure to light beyond an intensity threshold at approximately 405 nm and configured to transfer energy to the reactant.Type: GrantFiled: November 17, 2011Date of Patent: November 12, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Kwok Pong Chan, Evgenia Mikhailovna Kim, Robert Edgar Colborn, Eugene Pauling Boden
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Publication number: 20130296274Abstract: Compounds of the formula I in which R1, R2, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.Type: ApplicationFiled: September 14, 2011Publication date: November 7, 2013Applicant: Merck Patent GmbHInventors: Timo Heinrich, Frank Zenke, Michel Calderini, Djordje Musil
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Patent number: 8546564Abstract: Provided herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2 R3, m and n are defined herein. Also provided are pharmaceutically acceptable compositions that include a compound of formula I and a pharmaceutically acceptable excipient. Also provided are methods for treating FAAH-mediated disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound or composition of the present invention.Type: GrantFiled: April 7, 2010Date of Patent: October 1, 2013Assignee: Infinity Pharmaceuticals, Inc.Inventors: Alfredo C. Castro, Michael J. Grogan, Daniel A. Snyder
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Publication number: 20130252000Abstract: The embodiments described herein generally relate to compositions and articles including dye compounds having desirable optical properties, and related methods. In some cases, the compositions and articles may possess advantageous optical properties, including various degrees of absorbance, emission, and/or transmission at particular wavelengths or ranges of wavelength. Embodiments described herein may be useful as optical filters in protective eyewear applications.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Applicant: Revision Military, Ltd.Inventors: Larry Takiff, Kevin M. Bardon, Charles Lysogorski, Oliver Pentenrieder
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Publication number: 20130252024Abstract: Disclosed are a compound that emits fluorescence, particularly in its solid state, and is suited to provide a color converting material with various improved performance properties over prior art and a light emitter, a color conversion filter, a color conversion device, and a photoelectric device each containing the compound; particularly a Schiff base type compound of formula (I) and a coloring material, a color conversion layer, a light absorbing layer, a color conversion filter, a light absorbing filter, a color-converting light-emitting device, and a photoelectric device each containing the compound. The definition of the symbols in formula (I) is the same as in the specification.Type: ApplicationFiled: May 9, 2013Publication date: September 26, 2013Applicant: ADEKA CORPORATIONInventors: Mitsuhiro OKADA, Koichi SHIGENO
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Publication number: 20130244251Abstract: The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: I or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of neural stem cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can detect and separate neural stem cells without immunostaining, providing a much shorter and more convenient method for detection of neural stem cells.Type: ApplicationFiled: November 22, 2011Publication date: September 19, 2013Inventors: Young-Tae Chang, Seong-Wook Yun, Duanting Zhai, Kit Mun Cheryl Leong
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Patent number: 8519153Abstract: The present application is directed to compounds of Formula I: wherein R1-R9, X, Y and Z are as defined in the application, and to the use of the compounds of Formula I, for example, for the fluorescent labeling of oligonucleotides.Type: GrantFiled: September 22, 2011Date of Patent: August 27, 2013Assignee: Brock UniversityInventors: Hongbin Yan, Kha Tram
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Publication number: 20130217137Abstract: According to the present teachings, systems and methods for protein melt analysis are provided that utilizing a dye. In some embodiments, a method comprises preparing a sample by mixing at least one protein with a dye, and applying a controlled heating, while recording the fluorescence emission of the sample.Type: ApplicationFiled: January 25, 2013Publication date: August 22, 2013Applicant: Life Technologies CorporationInventors: Levente EGRY, Kyle Gee
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Patent number: 8513451Abstract: Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.Type: GrantFiled: May 30, 2008Date of Patent: August 20, 2013Inventor: Hee Chol Kang
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Patent number: 8513218Abstract: The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.Type: GrantFiled: March 30, 2011Date of Patent: August 20, 2013Assignee: Millennium Pharmaceuticals, Inc.Inventors: Paul E. Fleming, Jing Li
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Publication number: 20130190510Abstract: Amines and boranes are the archetypical Lewis bases and acids, respectively. The former can readily undergo one-electron oxidation to give radical cations, whereas the latter are easily reduced to afford radical anions. The present invention provides the synthesis of neutral tricoordinate boron derivatives, which act as a Lewis base, and undergoes one-electron oxidation into the corresponding radical cation. The present invention also provides borylene (H—B:) and borinylium (H—B+.) complexes stabilized by two cyclic (alkyl)(amino)carbenes. Ab initio calculations show that the HOMO [Highest Occupied Molecular Orbital] of the borane as well as the SOMO [Singly Occupied Molecular Orbital] of the radical cation are essentially a pair and a single electron in the p(?)-orbital of boron, respectively.Type: ApplicationFiled: July 23, 2012Publication date: July 25, 2013Applicant: The Regents of the University of CaliforniaInventors: Guy Bertrand, Rei Kinjo, Bruno Donnadieu
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Publication number: 20130189185Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.Type: ApplicationFiled: July 13, 2012Publication date: July 25, 2013Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Zibo LI, Francois P. GABBAI, Peter S. CONTI, Todd W. HUDNALL, Tzu-Pin LIN, Shuanglong LIU, Chiun-Wei HUANG
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Patent number: 8486311Abstract: The embodiments described herein generally relate to compositions and articles including dye compounds having desirable optical properties, and related methods. In some cases, the compositions and articles may possess advantageous optical properties, including various degrees of absorbance, emission, and/or transmission at particular wavelengths or ranges of wavelength. Embodiments described herein may be useful as optical filters in protective eyewear applications.Type: GrantFiled: March 21, 2012Date of Patent: July 16, 2013Assignee: Revision Military, Ltd.Inventors: Larry Takiff, Kevin M. Bardon, Charles Lysogorski, Oliver Pentenrieder
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Patent number: 8476461Abstract: Dipyrromethene-boron hydrophilic fluorescent compounds The invention concerns fluorescent and hydrophilic compounds meeting following formula (I): wherein: S1 is a group of formula —C?C-L?-A where L? is a linkage group and A is a polar functional group; S2 is a —C?C-L?-A group the same or different from S1; —F; —H; or a hydrocarbon chain optionally interrupted by one or more oxygen atoms, and use thereof, in particular in aqueous or hydrophilic media.Type: GrantFiled: December 18, 2009Date of Patent: July 2, 2013Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Gilles Ulrich, Raymond Ziessel, Song-Lin Niu, Alexandre Haefele, Thomas Bura
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Publication number: 20130150292Abstract: The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active inhibitor moiety in proximity to a target protease. In certain instances, compounds inhibit proteasomes and/or post-proline cleaving enzymes (PPCE), such as dipeptidyl peptidase IV. The compounds of the invention provide a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.Type: ApplicationFiled: September 14, 2012Publication date: June 13, 2013Applicant: Trustees of Tufts CollegeInventors: William W. Bachovchin, Hung-Sen Lai, Wengen Wu
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Patent number: 8415295Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.Type: GrantFiled: January 22, 2010Date of Patent: April 9, 2013Assignee: Phenomix CorporationInventors: David Alan Campbell, David T. Winn, Juan Manuel Betancort
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Patent number: 8389741Abstract: The invention relates to difluoroboradiazaindacene dyes of the formula (1) where R1=fluoro-substituted phenyl residue C6HmFn where n=1 to 5 and m+n=5; or fluoro-substituted naphthyl residue C10HmFn where n=1 to 9 and m+n=9; R2=CH3, C2H5, C3H7, or C4H9; R3=alkyl, aryl, or vinyl aryl; R4, R5=H, F, or an R4 and R5 bridging residue CH?CH—CH?CH; R6, R7=H, F, or an R6 and R7 bridging residue CH?CH—CH?CH; and R8=alkyl or aryl.Type: GrantFiled: August 26, 2010Date of Patent: March 5, 2013Assignee: Bam Bundesanstalt fuer Materialforschung und-PruefungInventors: Knut Rurack, Ana B. Descalzo, Tobias Fischer, Thomas Behnke
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Publication number: 20130032758Abstract: Described herein are devices, compositions, and methods for improving color discernment.Type: ApplicationFiled: August 2, 2012Publication date: February 7, 2013Inventors: Brett T. Harding, Sheng Li, Amane Mochizuki
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Publication number: 20130026426Abstract: A carbazole derivative represented by the following General Formula (1) where at least one aromatic ring has one to three substituents each represented by the following General Formula (2): in General Formula (1), Ar1 and Ar2 each independently represent a substituted or unsubstituted aryl group which may form a ring with a benzene ring, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted arylsilyl group, or a hydrogen atom, and Ar3 represents a substituted or unsubstituted aryl group, —X—Y—Z??(2) in General Formula (2), X represents a methylene group, a carbonyloxy group, an oxycarbonyl group, a carbonyl group, an oxygen atom or a sulfur atom, Y represents a substituted or unsubstituted alkylene group, and Z represents a carboxyl group, a hydroxyl group or a thiol group.Type: ApplicationFiled: March 29, 2012Publication date: January 31, 2013Inventors: Shigeyuki HARADA, Masaomi Sasaki