Boron Containing Patents (Class 548/405)
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Publication number: 20110212919Abstract: The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(1) R3—[—X—B(ZR1)—Y—]n—R4,??(2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(3) R3—[—X—B(ZR1)—]n—R4,??(4) R3—[—B(ZR2)—W—]n—R4,??(5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,??(6) R3—B(OH)2,??(7) R3—B(ZR1)—X—B(ZR2)—R4,??(8) R3—B(R1)—O—B(R2)—R4,??(9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,??(10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,??(11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(12) [R3—X—B(ZR1)—Y]2B(ZR2),??(13) wherein each symbol is as defined in the DESCRIPTION.Type: ApplicationFiled: August 11, 2009Publication date: September 1, 2011Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Katsuhiko Mikoshiba, Nobuyuki Nukina, Shoichiro Ozaki, Kouzo Hamada, Jun-Ichi Goto, Akinobu Suzuki, Etsuko Ebisui, Akiko Terauchi
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Publication number: 20110207941Abstract: The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, or especially of amides of the formula II, wherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.Type: ApplicationFiled: May 2, 2011Publication date: August 25, 2011Inventors: ULRICH BERENS, OLIVER DOSENBACH, DANIEL SPRENGER
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Publication number: 20110207701Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: ApplicationFiled: August 16, 2010Publication date: August 25, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Huchen Zhou, Dazhong Ding, Yasheen Zhou, Yong-Kang Zhang, Jacob J. Plattner
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Publication number: 20110207702Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: ApplicationFiled: October 15, 2009Publication date: August 25, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Robert Jacobs, Matthew Orr, Stephen Wring, Daitao Chen, Huchen Zhou, Dazhong Ding, Yiqing Feng, Long Yi, Vincent S. Hernandez, Yong-Kang Zhang, Jacob J. Plattner
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Publication number: 20110190496Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.Type: ApplicationFiled: April 13, 2011Publication date: August 4, 2011Inventors: Xin Chen, Heather Coate, Andrew Philip Crew, Han-Qing Dong, Ayako Honda, Mark Joseph Mulvihill, Paula A.R. Tavares, Jing Wang, Douglas S. Werner, Kristen Michelle Mulvihill, Kam W. Siu, Bijoy Panicker, Apoorba Bharadwaj, Lee D. Arnold, Meizhong Jin, Brian Volk, Quinghua Weng, James David Beard
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Publication number: 20110172187Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.Type: ApplicationFiled: November 11, 2010Publication date: July 14, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Vincent S. HERNANDEZ, Xiangeng Li, Suoming ZHANG, Tsutomu AKAMA, Yanchen ZHANG, Yang LIU, Jacob J. PLATTNER, Michael Richard Kevin ALLEY, Yasheen ZHOU, James A. NIEMAN
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Publication number: 20110171678Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.Type: ApplicationFiled: October 18, 2010Publication date: July 14, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
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Publication number: 20110166104Abstract: This invention provides, among other things, novel compounds useful for treating inflammatory conditions, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: ApplicationFiled: September 2, 2009Publication date: July 7, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Yasheen Zhou, Yong Kang Zhang, Tsutomu Akama, Kurt Jarnagin
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Publication number: 20110165603Abstract: The present invention relates to novel compounds which are capable as acting as fluorescent sensors or which are precursors for these and for the use of these for the assay of biological processes such as posttranslational modifications of biological molecules such as phosphorylation, de-phosphorylation, proteolytic cleavage, phosphodiesterase mediated hydrolysis of cyclic nucleotides, methylation, acetylation of proteins peptides, DNA, lipids and the detection of biomolecule interactions (e.g., protein-protein interactions). A small molecule sensor is described which can associate to phosphorylated biological targets via metal ion—phosphate association. The association event can be monitored as fluorescence quench, sensitized emission, fluorescence polarization or a combination thereof.Type: ApplicationFiled: August 26, 2009Publication date: July 7, 2011Applicant: Gyrasol Technologies Inc.Inventors: Frauke H. Rininsland, Shannon Keeley Wittenburg, Wendy L. Weatherford
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Patent number: 7973171Abstract: The invention relates to a process for the synthesis of dialkoxyorganoboranes, in particular to a process for the synthesis of dialkoxyorganoboranes by an ester exchange reaction. Moreover, the invention relates to a process for the synthesis of organo-oxazaborolidine catalysts (organo-CBS) and of trialkylboroxins. Furthermore, the invention relates to methods of using dialkoxyorganoboranes for the preparation of organo-CBS catalysts and in Suzuki-type coupling reactions.Type: GrantFiled: November 16, 2010Date of Patent: July 5, 2011Inventors: Elizabeth Burkhardt, William Atkins
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Publication number: 20110112051Abstract: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.Type: ApplicationFiled: January 13, 2011Publication date: May 12, 2011Applicant: Alantos Pharmaceuticals Holding, Inc.Inventors: Heiko KROTH, Tim Feuerstein, Frank Richter, Jürgen Boer, Michael Essers, Bert Nolte, Matthias Schneider, Matthias Hochguertel, Fritz-Frieder Frickel, Arthur Taveras, Christoph Steeneck
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Publication number: 20110086369Abstract: The present invention describes novel fluorescent compounds analogous to alkyl phospholipids, containing highly photostable fluorescent groups in the structure thereof and emitting in the visible spectrum wavelength zone. Said compounds are easily introduced to microorganisms, enabling the detection and identification of these organisms by means of fluorescence microscopy. The novel fluorescent compounds can also diagnose, rapidly and easily, the presence of pathogenic microorganisms characterised in that they are resistant to treatment with alkyl phospholipids.Type: ApplicationFiled: March 30, 2009Publication date: April 14, 2011Inventors: A. Ulises Acuña Fernández, Francisco Amat Guerri, Eugenia Carrillo Gallego, Valentín Hornillos Gomez Recuero, Susana Marcos Celestino, José María Requejo Isidro, Luis Ignacio Rivas López, José María Saugar Cruz, Carmen Del Aguila De La Puente, Jesús Merayo Lloves
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Patent number: 7906674Abstract: The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A?O, C, NH, or S; B?O, C, NH, or S; and R2 is selected from the group consisting of —CO—(CH2)n—CH3; —CO—(CH2)n—CHO; and —CO—(CH2)n—COOH, with n=3-7, with the proviso that in general formula (I), R1 is selected from the group consisting of —CH2—(CH2)n—X; and —CO—(CH2)n—X with n=5-11, wherein X is a fluorophore; and in general formula (II), R1 is selected from the group consisting of —CH?CH—(CH2)n—CH3 with n=9-15; —(CH2)n—CH3 with n=11-17; and —CO—(CH2)n—CH3 with n=10—16; and R3 is selected from the group consisting of —CO—(CH2)n—X; and —SO2—(CH2)n—X, with n=0-5, wherein X is a fluorophore.Type: GrantFiled: July 26, 2006Date of Patent: March 15, 2011Inventors: Albin Hermetter, Michael Trenker
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Patent number: 7906658Abstract: The present invention is directed to a method of treatment of a malcondition that can be regulated or normalized via inhibition of DPP-IV. The method involves administration of an effective amount of a pyrrolidine compound of the invention, such as would be present in a pharmaceutical composition of the invention, to mammals, especially humans, to affect a malcondition that can be regulated or normalized via inhibition of DPP-IV.Type: GrantFiled: August 2, 2007Date of Patent: March 15, 2011Assignee: Phenomix CorporationInventors: David Alan Campbell, David T. Winn, Juan Manuel Betancort
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Publication number: 20110054187Abstract: The invention relates to difluoroboradiazaindacene dyes of the formula (1) where R1=fluoro-substituted phenyl residue C6HmFn where n=1 to 5 and m+n=5; or fluoro-substituted naphthyl residue C10HmFn where n=1 to 9 and m+n=9; R2=CH3, C2H5, C3H7, or C4H9; R3=alkyl, aryl, or vinyl aryl; R4, R5=H, F, or an R4 and R5 bridging residue CH?CH—CH?CH; R6, R7=H, F, or an R6 and R7 bridging residue CH?CH—CH?CH; and R8=alkyl or aryl.Type: ApplicationFiled: August 26, 2010Publication date: March 3, 2011Applicant: BAM Bundesanstalt fuer Materialforschung und -pruefungInventors: KNUT RURACK, Ana B. Descalzo, Tobias Fischer, Thomas Behnke
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Patent number: 7897786Abstract: The invention relates to unsaturated dipyrromethene-boron borocarbons of formula (I) and the use thereof for fluorescence or electroluminescent analysis. The fluorescent properties are provided by the central ring of six atoms comprising the —N—B—N— sequence, R1 to R7 permitting the modification of the compound properties (fluorescence emission wavelength, quantitative fluorescent yield), at least one of the substituents S1 and S2 has a chromophore end group which permits an excitation of the molecule at wavelengths close to those of the substituent chromophore. A preferably selected from the chromophore substituents with a wavelength close to the ultraviolet which significantly increases the Stokes displacement.Type: GrantFiled: February 14, 2006Date of Patent: March 1, 2011Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite Louis Pasteur de StrasbourgInventors: Gilles Ulrich, Raymond Ziessel, Christine Goze
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Patent number: 7897787Abstract: A compound represented by the following general formula (I): [wherein R1 and R2 independently represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 and X2 represent hydrogen atom, an alkyl group, an alkoxy group, or a halogen atom), provided that R1 and R2 do not simultaneously represent hydrogen atom; R3 and R6 represent an alkyl group; R4 and R7 represent hydrogen atom, an alkyl group, carboxy group, an alkoxycarbonyl group, or sulfo group; and R5 and R8 represents an alkyl group, an aryl group, an alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group], or a salt thereof, which is usable for efficient screening for a chemical substance having applicability as a catalyst of the reaction of Michael addition.Type: GrantFiled: September 13, 2006Date of Patent: March 1, 2011Assignee: The University of TokyoInventors: Takuya Matsumoto, Takuji Shoda, Yasuteru Urano, Tetsuo Nagano
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Patent number: 7888398Abstract: This present invention can provide a novel pigment useful in color image displays to form blue pixels capable of providing high-level brightness and saturation, especially a finely-divided pigment which has bright hue and is excellent in pigment physical properties such as light fastness, solvent resistance and heat resistance, and a process for producing the same, a pigment dispersion making use of the pigment, and an ink for a color filters. The novel pigment is produced by forming into a pigment a subphthalocyanine represented by the following formula (1): wherein X is a halogen atom, presents diffraction peaks at diffraction angles (2?) 7.0°, 12.3°, 20.4° and 23.4° in x-ray diffraction, and has an average particle size of 120 to 20 nm.Type: GrantFiled: July 26, 2005Date of Patent: February 15, 2011Assignee: Dainichiseika Color & Chemicals Mfg. Co., Ltd.Inventors: Naoki Hirata, Hisao Okamoto, Yoshiyuki Zama, Michiei Nakamura, Tetsuya Yanagimoto, Hiroaki Yamada, Masahiro Tsuchiya
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Patent number: 7883786Abstract: The invention provides a novel compound used as a material for organic light-emitting elements, and an organic light-emitting element which has highly efficient and highly luminescent optical power and is superior in durability. The organic light-emitting element includes an anode and a cathode, and a layer which contains an organic compound and is held between the anode and the cathode.Type: GrantFiled: April 1, 2008Date of Patent: February 8, 2011Assignee: Canon Kabushiki KaishaInventors: Shigemoto Abe, Akihiro Senoo, Jun Kamatani, Satoshi Igawa, Naoki Yamada
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Patent number: 7884217Abstract: The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.Type: GrantFiled: October 31, 2007Date of Patent: February 8, 2011Assignee: Phenomix CorporationInventors: David Alan Campbell, David T. Winn, Juan Manuel Betancort
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Publication number: 20110015407Abstract: The present invention relates to a novel method for preparing atorvastatin. According to the present invention, provided are a novel intermediate of the preparation of atorvastatin and a method of preparing large amounts of atorvastatin in a safe manner using the intermediate.Type: ApplicationFiled: April 25, 2008Publication date: January 20, 2011Applicant: CHONG KUN DANG PHARMACEUTICAL CORP.Inventors: Soon Kil Ahn, Hong-Woo Lee, Choong Leol Yoo, Young-Min Kim, Chang Geun Song, Sung Kwun Kang, Jun A. You, Bong Kwan Soh, Dong Hyuk Nam
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Patent number: 7872017Abstract: The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.Type: GrantFiled: May 15, 2007Date of Patent: January 18, 2011Assignee: Abbott LaboratoriesInventors: Jianguo Ji, Tao Li, Christopher L. Lynch, Murali Gopalakrishnan
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Patent number: 7858598Abstract: Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.Type: GrantFiled: February 21, 2008Date of Patent: December 28, 2010Assignee: Morningside Ventures Limited & Versitech LimitedInventors: Dan Yang, Zhen-Ning Sun, Yan Chen, Fengqin Liu
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Publication number: 20100323988Abstract: This invention relates to DPP-IV inhibitory citrate or tartrate salts of pyrrolidinylaminoacetyl pyrrolid acid compounds that are physically and chemically stable, substantially non-deliquescent solids under ambient conditions.Type: ApplicationFiled: August 23, 2007Publication date: December 23, 2010Applicant: PHENOMIX CORPORATIONInventors: Zhen-Ping Wu, David A. Campbell, Julie M. Cherrington
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Publication number: 20100317621Abstract: Disclosed herein are ?-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising ?-aminoboronic acids and methods of use thereof.Type: ApplicationFiled: November 13, 2008Publication date: December 16, 2010Inventors: Christopher J. Burns, Randy W. Jackson
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Publication number: 20100284931Abstract: The invention generally relates to novel fluorescent phospholipid compounds, compositions comprising these compounds, and their use in a variety of diagnostic applications, including fluorescence imaging of tumors.Type: ApplicationFiled: May 11, 2009Publication date: November 11, 2010Inventors: Anatoly Pinchuk, Jamey P. Weichert, Marc Longino, Irawati Kandela, William R. Clarke
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Patent number: 7825249Abstract: The invention relates to novel metal complexes. Said compounds can be used as functional material in a series of different applications which in the broadest sense can be attributed to the electronics industry. The inventive compounds are described by the formula (1) and by compounds (1) to (52).Type: GrantFiled: May 14, 2005Date of Patent: November 2, 2010Assignee: Merck Patent GmbHInventors: Philipp Stössel, Esther Breuning
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Publication number: 20100272641Abstract: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.Type: ApplicationFiled: April 27, 2009Publication date: October 28, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: JACK MATHEW WEBSTER, FAISAL AHMED SYUD, BRIAN DUH-LAN LEE, PAUL SCHAFFER, RONG ZHANG, JENNIFER LYNNE HUNTINGTON, KANDE KANKANAMALAGE DAYARATHNA AMARASINGHE
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Publication number: 20100264406Abstract: A light emitting device material containing a pyrromethene compound represented by the general formula (1). It realized a luminescent element having a high luminescent efficiency and excellent color purity. Also provided is a luminescent element employing the materials.Type: ApplicationFiled: October 28, 2008Publication date: October 21, 2010Applicant: TORAY INDUSTRIES, INC.Inventors: Kazumasa Nagao, Tsuyoshi Tominaga
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Patent number: 7816531Abstract: The invention relates to novel metal complexes. Said compounds can be used as functional materials in a series of different types of applications that can be attributed in the broadest sense to the electronics industry The inventive compounds are defined by formula (1).Type: GrantFiled: July 14, 2005Date of Patent: October 19, 2010Assignee: Merck Patent GmbHInventors: Philipp Stössel, Esther Breuning
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Patent number: 7816562Abstract: The invention is amido-borate compounds containing one or more anionic amido-borate moieties comprising an organoborate anion wherein the boron atom is bonded to a nitrogen atom of ammonia or an organic compound containing one or more nitrogen atoms, such as a hydrocarbyl amine, a hydrocarbyl polyamine, or an aromatic heterocycle containing one or more nitrogen atoms, and a cationic counter ion.Type: GrantFiled: October 6, 2006Date of Patent: October 19, 2010Assignee: Dow Global Technologies Inc.Inventors: Shaoguang Feng, Gary L. Jialanella, Peter Nickias, Toni Ristoski
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Publication number: 20100252433Abstract: The invention relates to compositions and methods useful in the labeling and identification of changes in protein levels, changes in enzyme activity, and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These optical labeling molecules find utility in a variety of applications, including use in the field of proteomics.Type: ApplicationFiled: October 13, 2009Publication date: October 7, 2010Inventors: Edward DRATZ, Paul Grieco
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Publication number: 20100240611Abstract: Methods for preparing an inhibitor of dipeptidyl peptidase IV, as well as formulations of such inhibitors of dipeptidyl peptidase IV that have a high degree of stability including under warm, humid storage conditions.Type: ApplicationFiled: March 16, 2010Publication date: September 23, 2010Inventors: Matthew Ronsheim, Nhut Diep, Yuriy Kalyan, Graham Lawton, Peng Wang, Michael Ouellette
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Patent number: 7799526Abstract: A phosphoprotein detection reagent that selectively binds phosphoamino acids. Methods of generating and employing the reagent are also provided, as are methods of detecting modulation of protein phosphorylation are disclosed. Methods of detecting a change in state of a cell are also disclosed. Additionally, a kit for the detection of phosphoproteins is also disclosed.Type: GrantFiled: November 21, 2003Date of Patent: September 21, 2010Assignee: The University of North Carolina at Chapel HillInventor: Alan Howe
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Publication number: 20100203564Abstract: Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.Type: ApplicationFiled: May 30, 2008Publication date: August 12, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventor: Hee Chol Kang
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Publication number: 20100204484Abstract: The invention provides a crystalline form of a synthetic intermediate useful in the preparation of a DPP-IV inhibitor, a method for preparing the crystalline form of the intermediate, and a method of using the crystalline form of the intermediate in the preparation of the inhibitor.Type: ApplicationFiled: July 11, 2008Publication date: August 12, 2010Applicant: Phenomix CorporationInventor: Zhen-Ping Wu
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Publication number: 20100203645Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.Type: ApplicationFiled: August 31, 2009Publication date: August 12, 2010Inventors: Edward A. DRATZ, Paul A. GRIECO
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Publication number: 20100203637Abstract: The preparation and use of fluorescent cell markers of the structure F—S1-S2-L is described where F is a fluorophore, S1-S2 is a spacer linking F to L, and L is a diacyl lipid.Type: ApplicationFiled: September 6, 2007Publication date: August 12, 2010Inventors: Elena Korchagina, Nicolai Bovin, Stephen Henry
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Patent number: 7767828Abstract: The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.Type: GrantFiled: May 1, 2006Date of Patent: August 3, 2010Assignee: Phenomix CorporationInventors: David Alan Campbell, David T. Winn, Juan Manuel Betancort
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Publication number: 20100184942Abstract: Compounds (including polymers) for use in hybrid host materials which can be used in electroluminescent devices. The compounds comprise at least one electron-transporting moiety and at least one hole-transporting moiety which are joined by a flexible linker. Hybrid host materials comprising the compounds exhibit stability against phase separation, elevated glass transition temperature, morphological stability against crystallization, and isolation of the electron transporting moiety and hole transporting moiety ?-systems.Type: ApplicationFiled: January 22, 2010Publication date: July 22, 2010Inventors: Shaw H. Chen, Lichang Zeng, Thomas Yung-Hsin Lee
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Publication number: 20100163852Abstract: The present invention provides a light emitting device material which enables a light emitting device having high efficiency and excellent chromatic purity and durability using a light emitting device material containing a pyrene compound represented by formula (1), wherein any one of R1 to R10 is a group represented by formula (2), or 1 to 4 substituents is/are group(s) represented by formula (3), and a light emitting device using the same.Type: ApplicationFiled: June 8, 2007Publication date: July 1, 2010Inventors: Kazumasa Nagao, Seiichiro Murase
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Patent number: 7737241Abstract: The invention is a system for initiating free radical polymerization comprising: a) in one part, one or more amido-borate compounds containing one or more anionic amido-borate moieties comprising an organoborate wherein the boron atom is bonded to a nitrogen atom of ammonia or an organic compound containing one or more nitrogen atoms, such as a hydrocarbyl amine, a hydrocarbyl polyamine, or an aromatic heterocycle containing one or more nitrogen atoms and optionally containing one or more heteroatoms or heteroatom containing functional moieties, and one or more cationic counter ions and b) in a second part, a liberating compound which reacts with the nitrogen atom(s) bound to the boron atom(s) upon contact with the amido-borate to form an organoborane radical.Type: GrantFiled: October 6, 2006Date of Patent: June 15, 2010Assignee: Dow Global Technologies Inc.Inventors: Shaoguang Feng, Gary L. Jialanella, Peter Nickias, Toni Ristoski
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Publication number: 20100120160Abstract: A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R9 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.Type: ApplicationFiled: January 15, 2010Publication date: May 13, 2010Applicants: Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuo NAGANO, Yu Gabe, Yasuteru Urano
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Publication number: 20100120661Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH2)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.Type: ApplicationFiled: January 22, 2010Publication date: May 13, 2010Applicant: Phenomix CorporationInventors: David A. Campbell, David T. Winn, Juan M. Betancort
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Publication number: 20100113393Abstract: Salts of a peptide boronic acid drug, for example of Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)2. The counter-ion to the boronate may be an alkali metal or derived from a strongly basic organic nitrogen-containing compound.Type: ApplicationFiled: June 9, 2009Publication date: May 6, 2010Inventors: David Jonathan Madge, Mark Dolman, John Joseph Deadman, Anthony James Kennedy, Sophie Marie Combe-Marzelle, Sanjay Kumar Kakkar
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Patent number: 7696347Abstract: The present invention provides compounds which are useful as safe substitutes for the organotin reagent used in coupling reaction for the oxymethylation of aromatic rings, such as alkoxymethylation or hydroxymethylation, with a palladium catalyst and which can dispense with chromatographic purification with silica gel in the production and are suitable for mass production; and compounds applicable even to the oxymethylation of aromatic ring substrates which do not permit coupling reaction by conventional technique or have low reactivity.Type: GrantFiled: March 13, 2006Date of Patent: April 13, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Keigo Tanaka, Satoshi Inoue, Daisuke Ito, Norio Murai, Yosuke Kaburagi, Shuji Shirotori, Shuichi Suzuki, Yoshiaki Ohashi
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Publication number: 20100087396Abstract: The present invention relates to new compounds of formula I wherein Z is N; Y is CONR5, NR5CO, SO2NR5, NR5SO2, CH2NR5, NR5, NR5CONR5, CH2CO, CO, O or CH2O; X is CH or N; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S and said phenyl ring or 5 or 6 membered heteroaromatic ring may optionally be fused with a 5 or 6 membered saturated, partially saturated or unsaturated ring containing one or more atoms selected from C, N, O or S; Q is C1-6alkyl, C2-6alkenyl or C2-6alkynyl, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, such as provide compounds having a selective inhibiting effect at GSK3.Type: ApplicationFiled: September 28, 2009Publication date: April 8, 2010Inventors: Stefan Berg, Seven Hellberg, Peter Soderman
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Publication number: 20100087658Abstract: Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.Type: ApplicationFiled: March 5, 2008Publication date: April 8, 2010Applicant: Phenomix CorporationInventors: David Alan Campbell, Emília P.T. Leitão, Zhen-Ping Wu, Peng Wang
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Publication number: 20100076201Abstract: To provide a method for producing a wide variety of carbazole derivatives which have a simple and uncomplicated process and in which variations in the yield, purity, etc. of a desired substance which are caused by an aryl group introduced is reduced as much as possible. A method for producing a carbazole derivative represented by General Formula (1) is provided, in which 9-[4-(10-phenyl-9-anthryl)phenyl]-9H-carbazole having an active site at the 3-position of the carbazole skeleton and an aromatic compound having an active site are coupled. In the formula, Ar1 represents an aryl group with 6 to 13 carbon atoms in a ring, and Ar1 may have a substituent.Type: ApplicationFiled: September 16, 2009Publication date: March 25, 2010Inventors: Hiroki Suzuki, Sachiko Kawakami, Nobuharu Ohsawa, Satoshi Seo
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Publication number: 20100068733Abstract: A compound represented by the following general formula (I): wherein R1 represents an amino group which may be substituted with one or two alkyl groups; R2, R3, R4 and R5 independently represent an alkyl group; and R6 and R7 independently represent a monocarboxyalkyl group, a salt thereof, or an ester thereof, which is useful as a pH-sensitive fluorescent probe which emits intense fluorescence in an acidic region.Type: ApplicationFiled: November 15, 2007Publication date: March 18, 2010Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Yasuteru Urano, Daisuke Asanuma