Silicon Containing Patents (Class 548/406)
-
Patent number: 6743916Abstract: A process for producing an organotitanium compound capable of regioselectively converting a substituted acetylene compound into polysubstituted benzene or polysubstituted pyridine. The process comprises reacting an acetylene compound represented by the formula (1) [where R1 and R2 denote a C1-20 alkyl group or the like] in the presence of a prescribed titanium compound and a Grignard reagent with a compound represented by the formula (4) [where R3 and R4 denote a hydrogen atom or the like] and further reacting with a compound represented by the formula (5) [where R5 denotes a hydrogen atom or the like, Z denotes CR′ (where R′ denotes a hydrogen atom or the like), nitrogen atom, X6 denotes a halogen atom or the like, and m is 0 or 1] thereby giving the titanium compound represented by the formula (6) and/or (7).Type: GrantFiled: December 13, 2001Date of Patent: June 1, 2004Assignees: Nissan Chemical Industries, LtdInventor: Fumie Sato
-
Publication number: 20040059129Abstract: Novel optically active &Dgr;1-pyrrolines of the formula (I) 1Type: ApplicationFiled: July 28, 2003Publication date: March 25, 2004Inventors: Andrew Plant, Thomas Geller, Bernd Gallenkamp, Rolf Grosser, Albrecht Marhold, Christoph Erdelen, Andreas Turberg, Olaf Hansen
-
Patent number: 6709772Abstract: An organic electrically conductive compound represented by general formula (1): and an organic electroluminescent device using the compound are provided, wherein n is an integer from 1 to 10, k represents any of integers from 2 to n+1, Ar1, Ar1′, Ar2, and Ar2′ are substituted or non-substituted aromatic hydrocarbon rings or heterocyclic rings that share a bond between carbons at 2,3-positions or 4,5-positions of a pyrrole ring in general formula (1) and are fused with the pyrrole ring, respectively, Ar3 is a divalent group of a substituted or non-substituted aromatic hydrocarbon or heterocyclic compound, and R1, R1′, Rk, and Rk′ are aliphatic hydrocarbon groups or substituted or non-substituted aryl or heterocyclic groups, respectively.Type: GrantFiled: September 27, 2002Date of Patent: March 23, 2004Assignee: Mitsumi Electric Co., Ltd.Inventors: Norio Hasegawa, Akira Shiga, Youichi Itagaki
-
Patent number: 6706424Abstract: An organic electrically conductive compound represented by general formula (1): and an organic elctroluminescent device using the compound are provided, wherein n is an integer from 2 to 10, k represents any of integers from 1 to n, Ar1, Ar1′, Ar2, and Ar2′ are substituted or non-substituted aromatic hydrocarbon rings or heterocyclic rings that share a bond between carbons at 2,3-positions or 4,5-positions of a pyrrole ring in general formula (1) and are fused with the pyrrole ring, respectively, and Rk and Rk′ are aliphatic hydrocarbon groups or substituted or non-substituted aryl or heterocyclic groups, respectively.Type: GrantFiled: September 27, 2002Date of Patent: March 16, 2004Assignee: Mitsumi Electric Co., Ltd.Inventors: Norio Hasegawa, Akira Shiga, Youichi Itagaki
-
Publication number: 20040044190Abstract: Compositions and methods are disclosed which facilitate purification of oligomers and other compounds. The disclosed compositions are silyl compositions that can be directly coupled, or coupled through a linking group, to a compound of interest, preferably to an oligomer at the end of oligomer synthesis. The silicon atom includes between one and three sidechains that function as capture tags. In one embodiment, the capture tags are lipophilic, which allows a derivatized oligomer to be separated from failure sequences by reverse phase chromatography. In another embodiment, the capture tags are compounds with a known affinity for other compounds, which other compounds are preferably associated with a solid support to allow chromatographic separation. Examples include haptens, antibodies, and ligands. Biotin, which can bind to or interact with a streptavidin-bound solid support, is a preferred capture tag of this type.Type: ApplicationFiled: July 25, 2003Publication date: March 4, 2004Applicants: Sirna Therapeutics, Inc., Yale UniversityInventor: Brian S. Sproat
-
Publication number: 20040038140Abstract: A compound having the Formula I 1Type: ApplicationFiled: August 20, 2002Publication date: February 26, 2004Applicant: Xerox CorporationInventors: James M. Duff, John F. Graham, Timothy P. Bender, Yvan Gagnon, Andronique Ioannidis
-
Publication number: 20040034217Abstract: Intermediates A, which are important in the whole synthesis of vindoline; and a method of synthesizing intermediates respectively represented by the general formulae B and C. By the method, the target intermediates are effectively synthesized with satisfactory reproducibility. This synthesis method is especially suitable for mass production.Type: ApplicationFiled: March 19, 2003Publication date: February 19, 2004Inventors: Tohru Fukuyama, Hidetoshi Tokuyama
-
Publication number: 20040014984Abstract: Novel processes and intermediates are provided for the synthesis of derivatives of 4-amino-3-hydroxypyrrole-2-carboxylic acids that are useful as monomers for polyamides capable of binding dsDNA. According to one preferred reaction scheme, an alkyl alkoxymethylene nitroacetate (Formula VIII) is prepared by reaction of a trialkyl orthoformate or orthoacetate with a nitroacetate ester in the presence of a carboxylic anhydride. The compound of Formula VIII is condensed with an N-substituted glycine to yield an N-substituted (2-nitro-2-alkoxycarbonyl)vinyl glycinate ester (Formula VII). Ring closure in the presence of an alkali metal alkoxide yields a 4-nitro-3-hydroxypyrrole-2-carboxylic ester (Formula V). After blocking of the 3-hydroxy group to produce a further intermediate (Formula IV), the 4-nitro group is reduced to a 4-amino group (Formula III), and the 4-amino group is then blocked by reaction with a dicarbonate diester to produce the fully blocked intermediate (Formula II).Type: ApplicationFiled: May 9, 2003Publication date: January 22, 2004Inventors: Dennis P Phillion, Megh Singh
-
Publication number: 20030208012Abstract: The present invention provides a thiocarbonylthio compound represented by formula (I) 1Type: ApplicationFiled: April 24, 2002Publication date: November 6, 2003Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Lizamma Mathew, Kuo-Chen Shih
-
Patent number: 6576653Abstract: This invention relates to compounds of Formula I or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof or a pharmaceutically acceptable salts of the prodrugs. This invention also relates to pharmaceutical compositions comprising a compound of Formula I, and to methods of treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia.Type: GrantFiled: April 5, 2002Date of Patent: June 10, 2003Assignee: Pfizer Inc.Inventor: Daisy Joe Du Bois
-
Patent number: 6566413Abstract: The invention relates to novel cyclic siloxane compounds of the following general formula (I): in which: n=0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 preferably 1, 2, 3, 4, 5; A=H or C1-C15 alk(en)yl, C3-C15 cycloalk(en)yl, C6-C12 aryl, C8-C18 alkaryl, where, in the said radicals, in each case one or more C atoms can be replaced by O, C═O, O(C═O), SiR2 and/or NR, R being an aliphatic radical with 1 to 7 C atoms, in which one or more C atoms can be replaced by O, C═O, and/or O(C═O); B=E or a linear, branched or polycyclic aliphatic- or aromatic-groups-containing hydrocarbon radical which links 2 to 10 of the cyclosiloxane radicals defined above, less B, to one another and contains 2 to 50 C atoms and additionally 0 to 30 other atoms from the group O, N, S, P, Si, Cl, F, Br, I and from which correspondingly 1 to 9, preferably 1 to 4 of the above defined cyclosiloxane radicals, less B, are pending; E=A or a polymerizable group G—Q—L, where oType: GrantFiled: September 19, 2001Date of Patent: May 20, 2003Assignee: 3M ESPE AGInventors: Wolfgang Weinmann, Joachim Zech, Oswald Gasser, Rainer Guggenberger, Gunther Eckhardt, Peter Bissinger, Wolfgang Soglowek
-
Patent number: 6565837Abstract: A method for producing polysiloxane compositions, including an amphoteric class of organosilicone compositions, is provided.Type: GrantFiled: May 7, 2001Date of Patent: May 20, 2003Assignee: Mona Industries, Inc.Inventors: Dennis L. Fost, Abe Berger
-
Publication number: 20030050331Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.Type: ApplicationFiled: May 31, 2002Publication date: March 13, 2003Applicant: Medarex Inc.Inventors: Howard P. Ng, Danny P.C. McGee, Oliver L. Saunders, Valeri Martichonok, Guoxian Wu, Zhihong Li, Geoffrey T. Yarranton
-
Publication number: 20030009032Abstract: The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.Type: ApplicationFiled: April 4, 2002Publication date: January 9, 2003Inventors: Madiraju S.R. Murthy, Nancy A.E. Steenaart, Roy A. Johnson, Gordon C. Shore
-
Publication number: 20030009036Abstract: An E-isomeric fulleropyrrolidine compound of formula (I): 1Type: ApplicationFiled: July 24, 2002Publication date: January 9, 2003Inventors: Long Y. Chiang, Vijayaraj Anantharaj
-
Publication number: 20020137934Abstract: A new ligands that include a benzene ring in the backbone can be combined with a metal or metal precursor compound or formed into a metal-ligand complex catalyze a number of different chemical transformations, including olefin polymerization reactions. The ligands, complexes formed with the ligands and compositions including the ligands are useful catalysts, depending on the reaction.Type: ApplicationFiled: September 18, 2001Publication date: September 26, 2002Applicant: Symyx TechnologiesInventors: Anil Guram, Cheryl Lund, Howard W. Turner, Tetsuo Uno
-
Patent number: 6452032Abstract: Silicone-containing organic compounds useful as modulators of mammalian nuclear hormone receptors, particularly the retinoid receptors and the farnesoid receptors.Type: GrantFiled: June 9, 2000Date of Patent: September 17, 2002Assignee: Allergan Sales, LLCInventors: Richard L. Beard, Michael E. Garst, Roshantha A. Chandraratna
-
Patent number: 6420613Abstract: A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy to handle, and a reducing agent therefor. A reduced product of an unsaturated organic compound is obtained by mixing the unsaturated organic compound and a trichlorosilane together to reduce the unsaturated organic compound in the presence of a compound that forms a silicon complex having five coordinations upon acting on the trichlorosilane such as an N-formylated product of a secondary amine having not less than 3 carbon atoms. The invention further provides a reducing agent comprising a particular silicon complex.Type: GrantFiled: December 11, 2000Date of Patent: July 16, 2002Assignee: Tokuyama CorporationInventors: Fumiaki Iwasaki, Yoshihiro Matsumura, Osamu Onomura, Kenji Tanaka
-
Patent number: 6414162Abstract: Catalyst systems useful for olefin polymerization are disclosed. The catalyst systems include an activator and an organometallic complex. The complex, which incorporates at least one Group 3-10 transition or lanthanide metal, is uniquely prepared from an indenoindolyl dianion or its synthetic equivalent. A diverse array of monomeric, dimeric, polymeric, or zwitterionic complexes are available from the dianion or its equivalent.Type: GrantFiled: April 5, 2001Date of Patent: July 2, 2002Assignee: Equistar Chemicals, LPInventor: Sandor Nagy
-
Patent number: 6407244Abstract: The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.Type: GrantFiled: January 26, 2000Date of Patent: June 18, 2002Assignee: Gemin X Biotechnologies Inc.Inventors: Madiraju S. R. Murthy, Nancy A. E. Steenaart, Roy A. Johnson, Gordon C. Shore
-
Publication number: 20020042522Abstract: Novel processes and intermediates are provided for the synthesis of derivatives of 4-amino-3-hydroxypyrrole-2-carboxylic acids that are useful as monomers for polyamides capable of binding dsDNA. According to one preferred reaction scheme, an alkyl alkoxymethylene nitroacetate (Formula VIII) is prepared by reaction of a trialkyl orthoformate or orthoacetate with a nitroacetate ester in the presence of a carboxylic anhydride. The compound of Formula VIII is condensed with an N-substituted glycine to yield an N-substituted (2-nitro-2-alkoxycarbonyl)vinyl glycinate ester (Formula VII). Ring closure in the presence of an alkali metal alkoxide yields a 4-nitro-3-hydroxypyrrole-2-carboxylic ester (Formula V). After blocking of the 3-hydroxy group to produce a further intermediate (Formula IV), the 4-nitro group is reduced to a 4-amino group (Formula III), and the 4-amino group is then blocked by reaction with a dicarbonate diester to produce the fully blocked intermediate (Formula II).Type: ApplicationFiled: July 5, 2001Publication date: April 11, 2002Inventors: Dennis P. Phillion, Megh Singh
-
Publication number: 20020042396Abstract: There is provided amino acid derivatives of formula I, 1Type: ApplicationFiled: November 29, 2001Publication date: April 11, 2002Applicant: Astra ABInventors: David Gustafsson, Jan-Erik Nystrom
-
Patent number: 6369124Abstract: Aliphatic maleimides and methods using the same are disclosed. Polymerization of compositions which include the compounds of the invention may be activated by irradiating the composition with radiation.Type: GrantFiled: July 7, 1999Date of Patent: April 9, 2002Assignees: First Chemical Corporation, University of Southern MississippiInventors: Charles E. Hoyle, Shan Christopher Clark, E. Sonny Jönsson
-
Patent number: 6337343Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.Type: GrantFiled: March 29, 2000Date of Patent: January 8, 2002Assignee: AstraZeneca ABInventors: David Gustafsson, Jan-Erik Nyström
-
Patent number: 6331537Abstract: This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.Type: GrantFiled: December 2, 1999Date of Patent: December 18, 2001Assignee: GPI Nil Holdings, Inc.Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
-
Publication number: 20010051723Abstract: A (polycyclic secondary-amino)dialkoxysilane favorably employable as a catalyst for polymerization of &agr;-olefin can be prepared by reacting tetrachlorosilane or a mono (C1-C8) alkyltrichlorosilane with a polycyclic secondary-amine in a non-hydrous, non-alcoholic organic solvent in the presence of a hydrogen chloride-trapping reagent, to produce a (polycyclic secondary-amino) chlorosilane and reacting the (polycyclic secondary-amino) chlorosilane with an alkali metal alkoxide or an alkaline earth metal alkoxide in the presence of a lower alcohol.Type: ApplicationFiled: June 12, 2001Publication date: December 13, 2001Applicant: Ube Industries, Ltd.Inventors: Hiroyuki Ikeuchi, Yasuhisa Sakakibara, Masayoshi Oue
-
Patent number: 6323355Abstract: A high-efficiency organic luminous element by which blue luminescence with high luminance and high color purity becomes possible, which comprises at least one compound represented by general formula (A): wherein Ra, Rb, Rc and Rd each represents a hydrogen atom or a substituent group, with the proviso that at least one substituent group of Ra, Rb, Rc and Rd is a group represented by general formula (B): wherein Re and Rf each represents a hydrogen atom or a substituent group, and Ara represents an aryl group, a heteroaryl group or an alkenyl group; and when at least two substituent groups of Ra, Rb, Rc and Rd are groups represented by general formula (B), the groups represented by general formula (B) may be the same or different.Type: GrantFiled: February 20, 2001Date of Patent: November 27, 2001Assignee: Fuji Photo Film Co., Ltd.Inventor: Tatsuya Igarashi
-
Publication number: 20010044426Abstract: A compound selected from those of formula (I): 1Type: ApplicationFiled: April 12, 2001Publication date: November 22, 2001Inventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Francoise Lejeune, Didier Cussac
-
Publication number: 20010039345Abstract: Novel compounds comprising a C—C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes and in assays employing enzyme-labeled specific binding pairs.Type: ApplicationFiled: April 11, 2001Publication date: November 8, 2001Inventors: Hashem Akhavan-Tafti, Zahra Arghavani, Renuka DeSilva
-
Patent number: 6291513Abstract: The fungicidal compound 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophenecarboxamide (Formula (I)) has shown superior and unexpected control of the growth of the soil-borne fungus Gaeumannomyces graminis (Gg). The present invention provides a novel compound for synthesizing the compound of Formula (I) which uses the compound 4-hydroxy-4,5-dimethyl-2-trimethylsilanyl-dihydrothiophene-3-carboxylic acid allylamide (Formula (II)) as well as novel compounds of synthesizing the allylamide. In addition, Formula (II) itself has unexpectedly been found to provide control of Gg.Type: GrantFiled: July 5, 2000Date of Patent: September 18, 2001Assignee: Monsanto companyInventors: Wendell G. Phillips, Michael K. Mao, Chun Ma, Thomas L. Fevig
-
Patent number: 6255301Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.Type: GrantFiled: July 14, 1997Date of Patent: July 3, 2001Assignee: AstraZeneca ABInventors: David Gustafsson, Jan-Erik Nyström
-
Patent number: 6228967Abstract: Polysiloxane composition is provided having the formula: wherein: R1, which can be the same or different, is selected from R2, an amine containing group of the formula —(CH2)n—Fn1—Bn2F—NH2 or a functional group of the general formula: wherein at least one R1 is a pyrrolidone-containing ester or amide functional group as shown; R5 is hydrogen, alkyl or polyoxyalkylene; D is oxygen or nitrogen, x is 1 or 2, F is linear or branched alkylene; B is —NR9, oxygen or sulfur, wherein R9 is hydrogen or lower alkyl (C1-6); R2 can be the same or different and is selected from alkyl, aryl, alkenyl or alkeynyl; R3 and R4, which may be the same or different are selected from alkyl, aryl, capped or uncapped polyoxyalkylene, alkaryl, aralkylene or alkenyl; a is an integer from 0 to 50,000; and b is an integer from 0 to 100.Type: GrantFiled: October 6, 1998Date of Patent: May 8, 2001Assignee: Mona Industries, Inc.Inventors: Dennis L. Fost, Abe Berger
-
Patent number: 6166236Abstract: Novel monomers of the general formula ##STR1## where b is 0 or 1, a is 1, 2, 3 or 4, R.sup.2 is a monovalent alkyl radical and R is an organic radical. The novel monomers may be employed to produce novel copolymers useful as hydrogel, soft non-hydrogel and/or rigid gas permeable contact lens materials.Type: GrantFiled: January 21, 1997Date of Patent: December 26, 2000Assignee: Bausch & Lomb IncorporatedInventors: Ronald E. Bambury, David E. Seelye
-
Patent number: 6166222Abstract: The invention relates to a process for preparing chiral 3,4-dehydroproline compounds of formula (I), in which R, R' and R" have the meanings given in the description. The invention is characterized by a pyrrolecarboxylic acid derivative compound of formula (II) reacted first with an alkali or alkaline earth metal in ammonia and then with an aqueous salt solution or a compound of formula (III) in which X is a leaving group to form the final chiral product compound.Type: GrantFiled: December 1, 1999Date of Patent: December 26, 2000Assignee: BASF AktiengesellschaftInventor: Bernd Schafer
-
Patent number: 6143732Abstract: The Sesquiterpene derivatives are useful as antivirus agents, which are shown by the formula: ##STR1## wherein R.sup.1 is hydrogen or halogen; and R.sup.2 is hydrogen, halogen, --OR.sup.7 (wherein R.sup.7 is hydrogen etc.) or --NHR.sup.8 (wherein R.sup.8 is hydrogen etc.) etc., or R.sup.1 and R.sup.2 taken together may form oxo or .dbd.NR.sup.9 (wherein R.sup.9 is hydroxy etc.);R.sup.3 is hydrogen or halogen; R.sup.4 is hydrogen, halogen, --OR.sup.10 (wherein R.sup.10 is hydrogen etc.), or --NHR.sup.11 (wherein R.sup.11 is hydrogen etc.), or R.sup.3 and R.sup.4 taken together may form oxo or .dbd.NR.sup.12 (wherein R.sup.12 is hydroxy etc.) or R.sup.2 and R.sup.4 taken together may form an unsaturated bond or --O--;A is .dbd.NR.sup.5 (wherein R.sup.5 is hydrogen, lower alkyl etc.)R.sup.6 is hydrogen, cyano etc.,X is hydrogen, cyano etc.,Y.sup.1 and Y.sup.2 are both hydrogens, or taken together may form oxo;Z.sup.1 and Z.sup.2 are both hydrogens, or taken together may form oxo, or Z.sup.1 is hydrogen and Z.Type: GrantFiled: September 20, 1999Date of Patent: November 7, 2000Assignee: Shionogi & Co., Ltd.Inventors: Kenichi Sugita, Naohiko Hattori
-
Patent number: 6124490Abstract: Ionically cross-linked silicone polymers of a thickened gel-like consistency are made by reacting a diamino containing polysiloxane with an acid containing reactant selected from itaconic acid or the ester derivative thereof; substituted or unsubstituted cyclic and ankydride; substituted or unsubstituted conjugated olefinic acid or mixtures of the same at an elevated temperature in the presence of a low molecular weight silicone oil or other solvent until an ionically cross-linked zwitterionic siloxane polymer of a gel-like consistency is formed.Type: GrantFiled: October 26, 1999Date of Patent: September 26, 2000Assignee: Mona Industries, Inc.Inventors: John L. Gormley, Abe Berger, Dennis L. Fost
-
Patent number: 6107491Abstract: Diketopyrrolopyrroles of formula I ##STR1## wherein R.sub.1 is a radical of formula II--Y--X--Z--Q (II),whereinY is --CR.sub.3 R.sub.4, --SO.sub.2 --, --CO--, --Si(Hal).sub.2 --, --POHal--, wherein R.sub.3 and R.sub.4 are each independently of the other hydrogen or C.sub.1 -C.sub.4 alkyl, and Hal is halogen,X is an unsubstituted or substituted carbocylic or heterocyclic arylene group,Z is a single bond, uninterrupted linear or branched C.sub.1 -C.sub.30 alkylene, or linear or branched C.sub.2 -C.sub.30 alkylene which is interrupted once or more than once by a hetero atom, --CH.dbd.CH--,--C.tbd.C--, --N.dbd.CH--, --CH.dbd.N-- or --NH--, or is C.sub.5 -C.sub.12 cycloalkylene,Q is a polyreactive functional group, andR.sub.2 is C.sub.1 -C.sub.6 alkyl, ##STR2## or R.sub.1, and R.sub.7 is hydrogen or C.sub.1 -C.sub.Type: GrantFiled: January 26, 1999Date of Patent: August 22, 2000Assignee: Ciba Specialty Chemicals CorporationInventor: Sameer Eldin
-
Patent number: 6100358Abstract: A polysiloxane composition including an amphoteric class of organosilicone composition is provided having the formula: ##STR1## wherein: R is selected from R.sub.2 or --OR.sub.9, wherein R.sub.9 is hydrogen or alkyl;R.sub.1, which can be the same or different, is selected from R.sub.2, a diamine containing group of the formula --F.sub.1 --NR.sub.9 --F--NH.sub.2, and at least one pyrrolidone-containing functional carboxyl group of the general formula: ##STR2## wherein R.sub.5 is hydrogen, lower alkyl (C.sub.1-6) or alkali metal; F.sub.1 is linear or branched alkylene; F is linear or branched alkylene; B is --NR.sub.7, wherein R.sub.7 is hydrogen or a dicarboxylic group;R.sub.2 is selected from alkyl, aryl or olefinic;R.sub.3 and R.sub.Type: GrantFiled: September 23, 1998Date of Patent: August 8, 2000Assignee: Mona IndustriesInventors: Dennis L. Fost, Abe Berger
-
Patent number: 6084106Abstract: The invention relates to a new class of alkoxy silane compounds of the following general formula: ##STR1## wherein R is aliphatic or aromatic having from 1 to about 15 carbon atoms and R'comprises a hydrolyzable alkoxy functionality. These compounds are particularly useful as adhesion promoters when used with adhesives such as, for example, phenylethynyl terminated polyimide or polysulfide adhesives. The invention also relates to a method of synthesizing the alkoxy silane compounds defined above.Type: GrantFiled: April 18, 1996Date of Patent: July 4, 2000Assignee: Thiokol CorporationInventors: Russell A. Crook, Robert B. Wardle
-
Patent number: 6051568Abstract: There is provided amino acid derivative formula I, ##STR1## wherein p, q, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.Type: GrantFiled: August 7, 1996Date of Patent: April 18, 2000Assignee: Astra AktiebolagInventors: David Gustafsson, Jan-Erik Nystrom
-
Patent number: 6037341Abstract: Compounds having potent antimicrobial effects over Gram-positive bacteria and Gram-negative bacteria, a high stability to .beta.-lactamases and DHP-I and a high safety for the human body and a process for producing the same. Carbapenem compounds represented by the following general formula (I) or salts thereof: ##STR1## wherein the ring A represents a 3- to 7-membered non-aromatic ring containing at least one nitrogen atom and optionally having a substituent other than R.sup.6 ; R.sup.1 represents hydrogen or methyl; R.sup.2 and R.sup.5 are the same or different and each represents hydrogen or a protecting group of the hydroxyl group; R.sup.3 represents hydrogen or a protecting group of the carboxyl group; R.sup.4 represents hydrogen, lower alkyl or a protecting group of the amino group; R.sup.6 represents: (1) hydrogen, (2) lower alkyl, optionally substituted by an optionally protected hydroxy, carbamoyl, formimidoyl, acetimidoyl or ##STR2## wherein R.sup.7 and R.sup.Type: GrantFiled: December 18, 1996Date of Patent: March 14, 2000Assignee: Eisai Co., Ltd.Inventors: Nobuaki Sato, Manabu Sasho, Atsushi Kamata, Takaaki Suzuki, Isao Sugiyama, Kanemasa Katsu, Takeshi Suzuki
-
Patent number: 6018011Abstract: The present invention relates to a polyorganosiloxane having at least one dialkoxyorganosiloxy group, where the organo radical is a substituted amidoalkyl radical.Type: GrantFiled: June 17, 1998Date of Patent: January 25, 2000Assignee: Huels Silicone GmbHInventors: Uwe Scheim, Peter Jenkner, Robert Lehnert
-
Patent number: 5994270Abstract: Plant disease caused by soil-borne fungus Gaeumannonyces graminis (Gg) is controlled by applying to the seed or the soil a fungicide which has the following general formula: ##STR1##Type: GrantFiled: September 11, 1996Date of Patent: November 30, 1999Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Matthew James Graneto, John Kennedy Pratt, Sai Chi Wong
-
Patent number: 5952369Abstract: A compound of formula (I) ##STR1## and its pharmaceutically acceptable salt, wherein A is hydrogen or OY, wherein Y is a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkyloxy and carboxy-C.sub.1 -C.sub.4 alkyloxy;X is phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralone-6-yl,C.sub.1 -C.sub.4 alkylenedioxy, pyridyl, furyl and thienyl these groups optionally being substituted with up to three substituents selected from halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, NO.sub.2, CF.sub.3 and SO.sub.2 CH.sub.3 ; andR is hydrogen, C.sub.1 -C.sub.4 alkyl or a hydroxy protecting group.Type: GrantFiled: September 26, 1997Date of Patent: September 14, 1999Assignee: Pfizer IncInventor: Fumitaka Ito
-
Patent number: 5919944Abstract: Diketopyrrolopyrroles of formula I ##STR1## wherein R.sub.1 is a radical of formula II--Y--X--Z--Q (II),whereinY is --CR.sub.3 R.sub.4, --SO.sub.2 --, --CO--, --Si(Hal).sub.2 --, --POHal--, wherein R.sub.3 and R.sub.4 are each independently of the other hydrogen or C.sub.1 -C.sub.4 alkyl, and Hal is halogen,X is an unsubstituted or substituted carbocylic or heterocyclic arylene group, Z is a single bond, uninterrupted linear or branched C.sub.1 -C.sub.30 alkylene, or linear or branched C.sub.2 -C.sub.30 alkylene which is interrupted once or more than once by a hetero atom, --CH.dbd.CH--, --C.tbd.C--, --N.dbd.CH--, --CH.dbd.N-- or --NH--, or is C.sub.5 -C.sub.12 cycloalkylene,Q is a polyreactive functional group, andR.sub.2 is C.sub.1 -C.sub.6 alkyl, ##STR2## or R.sub.1, and R.sub.7 is hydrogen or C.sub.1 -C.sub.Type: GrantFiled: July 20, 1998Date of Patent: July 6, 1999Assignee: Ciba Specialty Chemicals CorporationInventor: Sameer Eldin
-
Patent number: 5849313Abstract: A silicone-containing phospholipid having the general formula: ##STR1## wherein: A is selected from H, M or R.sub.9 --Y--;A.sub.1 is selected from H, OH, OM or R.sub.9 --Y--O--;M is a cation;Y is alkylene;x is 0 or an integer from 1-5; andR.sub.9 is a mixture of a organosilicone carboxyl functional moiety of the formula: ##STR2## wherein: R.sub.10 is the silicone backbone chain to which at least one pyrrolidone containing carboxyl functional group is attached;F is linear or branched alkylene of 1-12 carbon atoms;X.sup.- is an anion;n is 0 or 2;n.sup.1 is 0 or 1;n.sup.2 is 0 or 1;B is --NR.sub.11 sulfur or oxygen, wherein R11 hydrogen or lower alkyl (C.sub.1-6); andd is one or greater;an organic amidoamine moiety and/or an organic tertiary amine moiety.Type: GrantFiled: April 7, 1997Date of Patent: December 15, 1998Assignee: Mona Industries, Inc.Inventors: Dennis L. Fost, Abe Berger
-
Patent number: 5840914Abstract: The present invention relates to novel trialkylsilyloxy derivatives of 7-ethyltryptophol useful in the preparation of etodolac, and methods of making them, and methods of using them to prepare etodolac.Type: GrantFiled: October 24, 1996Date of Patent: November 24, 1998Assignee: Teva Pharmaceutical Industries, Ltd.Inventors: Giobbio Vincenzo, Polastri Franco
-
Patent number: 5834447Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are C or N and are part of an aromatic ring selected from benzene, pyridine, thiophene, furan, pyrrole, pyrazole, thiazole, and isothiazole;A is selected from --C(X)--amine, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from --C(R.sub.3).sub.p H.sub.(2-p) --, --N(R.sub.3).sub.m H.sub.(1-m) --, --S(O).sub.Type: GrantFiled: December 8, 1995Date of Patent: November 10, 1998Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
-
Patent number: 5817730Abstract: A polysiloxane composition including an amphoteric class of organosilicone composition is provided having the formula: ##STR1## wherein: R.sub.1, which can be the same or different, is selected from R.sub.2, a diamine containing group of the forumula --F.sub.1 --B--F--NH.sub.3 and at least one pyrrolidone-containing functional carboxyl group of the general formula: ##STR2## wherein R.sub.5 is hydrogen, lower alkyl (C.sub.1-6) or alkali metal; F.sub.1 is linear or branched alkylene; F is linear or branched alkylene of 1-10 carbon atoms; B is --NR.sub.9, wherein R.sub.9 is hydrogen or lower alkyl (C.sub.1-6);R.sub.2 can be the same or different and is selected from alkyl, aryl or olefinic;R.sub.3 and R.sub.4, which may be the same or different are selected from alkyl, aryl, capped or uncapped polyoxyalkylene, alkaryl, aralkylene or alkenyl;a is an integer from 0 to 50,000; andb is an integer from 0 to 100.Type: GrantFiled: May 22, 1996Date of Patent: October 6, 1998Assignee: Mona Industries, Inc.Inventors: Abe Berger, Dennis L. Fost
-
Patent number: 5807955Abstract: An uncapped polysiloxane composition is provided having the formula: ##STR1## wherein: R is selected from R.sub.2 or --OR.sub.9 wherein R.sub.9 is hydrogen or alkyl;R.sub.1, which can be the same or different, is selected from R.sub.2, an amine containing group of the formula --(CH.sub.2).sub.n --F.sub.n1 --B.sub.n2 --F--NH.sub.2 functional carboxyl group of the general formula: ##STR2## wherein R.sub.5 is hydrogen, alkyl or alkali metal; F is linear or branched alkylene; B is --NR.sub.9, oxygen or sulfur, wherein R.sub.9 is hydrogen or lower alkyl (C.sub.1-6);R.sub.2 can be the same or different and is selected from alkyl, aryl, alkenyl or alkeynyl;R.sub.3 and R.sub.4, which may be the same or different are selected from alkyl, aryl, capped or uncapped polyoxyalkylene, alkaryl, aralkylene or alkenyl;a is an integer from 0 to 50,000; andb is an integer from 0 to 100.Type: GrantFiled: January 21, 1997Date of Patent: September 15, 1998Assignee: Mona Industries, Inc.Inventors: Abe Berger, Dennis L. Fost