Chalcogen Or Nitrogen Attached Indirectly To The Tricyclo Ring System By Acyclic Nonionic Bonding Patents (Class 548/444)
-
Patent number: 8232312Abstract: The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.Type: GrantFiled: March 14, 2008Date of Patent: July 31, 2012Assignee: Boehringer Ingelheim International GmbHInventors: Holger Wagner, Elke Langkopf, Matthias Eckhardt, Ruediger Streicher, Corinna Schoelch, Annette Schuler-Metz, Alexander Pautsch
-
Publication number: 20120175599Abstract: [Problem] An organic compound of excellent characteristics is provided that exhibits excellent hole-injecting/transporting performance with electron blocking ability, and that has high stability in the thin-film state and high luminous efficiency, the organic compound being provided as material for an organic electroluminescent device having high efficiency and high durability. The invention also provides a high-efficient, high-durable organic electroluminescent device using the compound. [Means for Resolution] The compound is of the following general formula having a carbazole ring structure. The organic electroluminescent device includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes, and the compound is used as a constituent material of at least one organic layer.Type: ApplicationFiled: August 25, 2010Publication date: July 12, 2012Applicant: Hodogaya Chemical Co., Ltd.Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi, Shigeru Kusano
-
Publication number: 20120149915Abstract: Disclosed is a process for the preparation of N-alkyl carbazole. Said process comprises: a) chlorinating cyclohexanone to form 2-chlorocyclohexanone; b) reacting 2-chlorocyclohexanone with N-ethyl aniline to form 2-(N-ethyl anilino) cyclohexanone; c) cyclizing 2-(N-ethyl anilino) cyclohexanone by refluxing with simultaneous water removal to obtain 9-ethyltetrahydrocarbazole; d) treating 9-ethyl-tetrahydrocarbazole with concentrated hydrochloric acid followed by water wash for removing N-ethyl aniline; e) dehydrogenating 9-ethyltetrahydrocarbazole by heating 9-ethyltetrahydrocarbazole in a solvent, in presence of a catalyst to obtain N-alkyl carbazole.Type: ApplicationFiled: June 10, 2010Publication date: June 14, 2012Inventor: Keki Hormusji Gharda
-
Patent number: 8198462Abstract: The present invention relates to a dendritic photoactive compound that comprises oxime ester and a method for producing the same. Since the compound according to the present invention comprises two or more oxime ester groups and chromophores in one molecule at the same time, the solubility in respects to the organic solvent and the efficiency for producing a radical by absorbing ultraviolet rays are excellent. In addition, it can act as an effective initiator in respects to the photopolymerization of the unsaturated group, in particular, the acryl compound.Type: GrantFiled: July 15, 2008Date of Patent: June 12, 2012Assignee: LG Chem, Ltd.Inventors: Keon-Woo Lee, Chang-Ho Cho, Kyoung-Hoon Min, Raisa Kharbash, Chang-Soon Lee, Sung-Hyun Kim
-
Publication number: 20120098413Abstract: Organic compounds and organic electroluminescent devices employing the same are provided.Type: ApplicationFiled: December 21, 2010Publication date: April 26, 2012Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jin-Sheng Lin, Meng-Ting Lee, Heh-Lung Huang
-
Publication number: 20120095233Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.Type: ApplicationFiled: April 16, 2008Publication date: April 19, 2012Applicant: TAKEDA SAN DIEGO, INC.Inventors: Jason W. Brown, Qing Dong, Bheema R. Paraselli, Jeffrey A. Stafford, Michael B. Wallace, Hasanthi Wijesekera, Nicholas Scorah
-
Patent number: 8124644Abstract: The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical compositions comprising the novel amorphous and crystalline forms and uses thereof.Type: GrantFiled: May 8, 2009Date of Patent: February 28, 2012Assignee: Teva Pharmaceutical Industries Ltd.Inventor: Sigalit Levi
-
Publication number: 20120043531Abstract: A compound for an organic optoelectronic device, an organic light emitting diode, and a display device including the organic light emitting diode, the compound being represented by the following Chemical Formula 1:Type: ApplicationFiled: August 18, 2011Publication date: February 23, 2012Inventors: Sung-Hyun JUNG, Dal-Ho HUH, Dong-Wan RYU, Kyoung-Mi LEE, Eui-Su KANG, Mi-Young CHAE
-
Publication number: 20120041044Abstract: The present invention relates to a process for the preparation of carvedilol as well as of the optically active R and S enantiomers thereof and of mixtures of these enantiomers and, more particularly, relates to an improved process for the preparation of carvedilol and its enantiomers characterized by the use of ethyl acetate as reaction solvent.Type: ApplicationFiled: October 27, 2011Publication date: February 16, 2012Applicant: ZACH SYSTEM S.P.A.Inventors: Elisenda Trepat Guixer, Anna Munoz Alvarez, Marta Pomares Marco, Francisco Marquillas Olondriz
-
Patent number: 8114900Abstract: The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical compositions comprising the novel amorphous and crystalline forms and uses thereof.Type: GrantFiled: May 8, 2009Date of Patent: February 14, 2012Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Santiago Ini, Sigalit Levi, Mili Abramov, Eran Turgeman
-
Patent number: 8101781Abstract: The present invention relates to a process for the efficient preparation of highly optical pure chiral carvedilol. According to the present invention, a chiral oxazolidin-2-one or oxazolidin-2-thione having formula 2, produced from the reaction of N-protected 2-(2-methoxyphenoxy)ethylamine with a chiral glycidol derivative is used as a key intermediate for the preparation of the chiral carvedilol. Specifically, the process for the preparation of the chiral carvedilol comprises a) reacting a compound of formula 2 with a halogenation agent, a sulfonation agent or a mitsunobu reagent to activate a hydroxyl group of the compound of formula 2, followed by nucleophilic substitution reaction with 9H-4-hydroxy carbazole to produce a compound of formula 7, and b) subjecting the obtained compound of formula 7 to a deprotection reaction in a presence of an inorganic base to produce the targeted chiral carvedilol. The process of the present invention can be accomplished in a mild condition.Type: GrantFiled: August 31, 2006Date of Patent: January 24, 2012Assignees: AHN-Gook Pharmaceutical Co., Ltd., RSTech CorporationInventors: Seong-Jin Kim, Chang Woo Jong, Hyun Bin Kang, Byung Hyun Moon, Long Guo Quan, Duk Kwon Won, Kyung Yong Jin
-
Publication number: 20120012821Abstract: The present invention relates to silyl- and heteroatom-substituted compounds selected from carbazoles, dibenzofurans, dibenzothiophenes and disilylbenzophospholes of the formula (I) or (I*), to the use of the compounds of the formula (I) or (I*) in organic electronics applications, preferably in organic light-emitting diodes, to an organic light-emitting diode comprising at least one compound of the formula (I) or (I*), to a light-emitting layer comprising at least one compound of the formula (I) or (I*), to a blocking layer for holes/excitons comprising at least one compound of the formula (I) or (I*), and to an apparatus selected from the group consisting of stationary visual display units, mobile visual display units, illumination units, keyboards, items of clothing, furniture and wallpaper, comprising at least one inventive organic light-emitting diode.Type: ApplicationFiled: December 14, 2009Publication date: January 19, 2012Applicants: BASF SE, KONINKLIJKE PHILIPS ELECTRONICS N.V., OSRAM OPTO SEMICONDUCTORS GMBHInventors: Nicolle Langer, Christian Schildknecht, Soichi Watanabe, Evelyn Fuchs, Gerhard Wagenblast, Christian Lennartz, Oliver Molt, Korinna Dormann, Chuanjie Loh, Arvid Hunze, Ralf Krause, Guenter Schmid, Karsten Heuser, Volker van Elsbergen, Herbert Friedrich Boerner, Stefan Kirsch
-
Publication number: 20120012832Abstract: There are provided an aromatic monoamine derivative having a fluorene structure-containing organic group and an aromatic hydrocarbon group-containing organic group, and an organic electroluminescent element containing an organic thin film layer composed of a single layer or plural layers while including at least a light emitting layer, the organic thin film layer being between a cathode and an anode, wherein at least one layer of the organic thin film layer, particularly a hole transport layer, contains the aromatic amine derivative alone or as a component of a mixture. An organic electroluminescent element which maintains high luminous efficiency even if exposed to a high temperature environment, and has a low driving voltage and a long emission lifetime, and an aromatic amine derivative capable of realizing the organic electroluminescent element are provided.Type: ApplicationFiled: March 18, 2010Publication date: January 19, 2012Applicant: Mitsui Chemicals, Inc.Inventors: Nobuhiro Yabunouchi, Tomoki Kato, Takahiro Fujiyawa, Yoshiyuki Totani
-
Patent number: 8088836Abstract: An oxime ester compound represented by the following general formula (I): (the symbols of which are defined in the specification) is used as the photopolymerization initiator in a photosensitive resin composition.Type: GrantFiled: February 16, 2010Date of Patent: January 3, 2012Assignee: Nippon Chemical Works Co., Ltd.Inventor: Yuji Taguchi
-
Publication number: 20110318692Abstract: The present invention relates to a photoactive compound of a novel structure represented by Chemical Formula 1 below In Chemical Formula 1, R1 and R2, R3, and A are as defined in the specification, and a photosensitive resin composition comprising the same. The photoactive compound of the present invention comprises a nitro group and a phosphonate structure and thus exhibits excellent sensitivity through efficient absorption for UV light, excellent compatibility between the photoactive compound and the alkali-soluble binder resin, and an improved solubility of the photosensitive resin composition. Furthermore, the photosensitive resin composition of the present invention has excellent residual film thickness and mechanical strength characteristics and heat-resistant, chemical-resistant, and development-resistant properties.Type: ApplicationFiled: February 12, 2010Publication date: December 29, 2011Applicant: LG CHEM, LTD.Inventors: Chang Ho Cho, Sung Hyun Kim, Raisa Kharbash, Keon Woo Lee, Dong Kung Oh, Won Jin Cung, Sang Kyu Kwak, Chang Soon Lee
-
Publication number: 20110312918Abstract: The present invention provides a novel mechanistic pathway and methods related to this pathway for the identification of compounds for the treatment of diseases involving cell proliferation, invasion and/or metastasis such as cancer. In particular, the instant invention relates to the phosphatase activity of Eya and the Eya-Six complex as a target for identifying novel therapeutic agents for the treatment of proliferative, invasive and/or metastatic disorders, and compositions identified using the methods disclosed herein.Type: ApplicationFiled: December 8, 2009Publication date: December 22, 2011Applicant: Children's Hospital Medical CenterInventor: Rashmi Hegde
-
Publication number: 20110306722Abstract: Surface-modified polymer films for coating are provided, wherein the surface is modified by covalent binding of nano- or micro-particles comprising a photoreactive species. The surface of the polymer film, e.g. a parylene film, may be modified by covalent binding of nano- or micro-particles of a polymer, e.g. a conductive bifunctional polymer further comprising a chemically reactive functional group, or of a hybrid organic-inorganic oxide, e.g., silica, network comprising a photoreactive species. Further provided are: (i) polymerizable monomers, the conductive bifunctional polymers obtained therefrom; (ii) a hybrid photoreactive organic-inorganic oxide network; and (iii) micro- or nano-particles made from (i) or (ii).Type: ApplicationFiled: June 7, 2011Publication date: December 15, 2011Applicant: BAR-ILAN UNIVERSITYInventors: Jean-Paul Lellouche, Maria Naddaka, Anna Peled, Ejabul Mondal
-
Publication number: 20110282018Abstract: The present invention generally relates to a process that selectively polymerizes ethylene in the presence of an alpha-olefin, and to a metal-ligand complex (precatalyst) and catalyst useful in such processes, and to related compositions. The present invention also generally relates to ligands and intermediates useful for preparing the metal-ligand complex and to processes of their preparation.Type: ApplicationFiled: May 11, 2011Publication date: November 17, 2011Inventors: Jerzy Klosin, Pulikkottil J. Thomas, Robert D. Froese, Xiuhua Cui
-
Publication number: 20110278552Abstract: The present invention provides a material for an organic electroluminescence device having a specific structure in which a dibennzofuranyl group or a dibenzothiophenyl group is bonded at an N-position (9-position) of a carbazolyl group and an organic electroluminescence device which is provided with one or more organic thin film layers including a light emitting layer between a cathode and an anode and in which at least one layer of the organic thin film layers described above contains the material for an organic electroluminescence device according to the present invention.Type: ApplicationFiled: February 15, 2011Publication date: November 17, 2011Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Masaki Numata, Hideaki Nagashima
-
Patent number: 8058453Abstract: A cost-effective, industrially feasible process for the manufacture of crystalline Carvedilol Form-II using novel Carvedilol salts comprises the steps of reacting 4-(2,3-epoxy propoxy)carbazole (II) with 2-(2-methoxy phenoxy)ethyl amine (III) followed by acidification with mineral acid in presence of an organic solvent to yield acid addition salts, treatment of the said salts with base(s) in presence of organic solvent(s), water and isolation from the organic solvent(s) followed by crystallization from ethyl acetate.Type: GrantFiled: December 22, 2008Date of Patent: November 15, 2011Assignee: Matrix Laboratories Ltd.Inventors: Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar, Ketavarapu Narasimha Rao, Jammula Vera Venkata Krishna Kishore
-
Patent number: 8048886Abstract: The present invention relates to novel IAP inhibitor compounds of formula I:Type: GrantFiled: December 7, 2007Date of Patent: November 1, 2011Assignee: Novartis AGInventors: Zhuoliang Chen, Run-Ming David Wang, Ming Chen, Christopher Sean Straub, Leigh Zawel
-
Publication number: 20110230488Abstract: The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesised and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.Type: ApplicationFiled: November 25, 2009Publication date: September 22, 2011Applicant: TRT PHARMA INC.Inventors: Jian Hui Wu, Gerald Batist, Jinming Zhou, Guoyan Geng, Rongtuan Lin
-
Patent number: 8021764Abstract: A phenylcarbazole-based compound is represented by Formula 1, and has superior electric properties and charge transport abilities, and thus is useful as a hole injection material, a hole transport material, and/or an emitting material which is suitable for fluorescent and phosphorescent devices of all colors, including red, green, blue, and white colors. The phenylcarbazole-based compound is synthesized by reacting carbazole with diamine. The organic electroluminescent device manufactured using the phenylcarbazole-based compound has high efficiency, low voltage, high luminance, and a long lifespan.Type: GrantFiled: November 25, 2005Date of Patent: September 20, 2011Assignee: Samsung Mobile Display Co., Ltd.Inventors: Seok-Hwan Hwang, Young-Kook Kim, Chang-Ho Lee, Seok-Jong Lee, Seung-Gak Yang, Hee-Yeon Kim
-
Patent number: 8022094Abstract: The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical compositions comprising the novel amorphous and crystalline forms and uses thereof.Type: GrantFiled: June 28, 2007Date of Patent: September 20, 2011Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Santiago Ini, Sigalit Levi, Michal Rafilovich, Judith Aronhime, Mili Abramov, Ron Bar-Shavit, Eran Turgeman
-
Publication number: 20110210318Abstract: The present invention provides a novel compound that is capable of largely improving a life time, efficiency, electrochemical stability, and thermal stability of an organic electronic device, and an organic electronic device that comprises an organic material layer comprising the compound.Type: ApplicationFiled: August 21, 2009Publication date: September 1, 2011Applicant: LG CHEM, LTD.Inventors: Jae-Soon Bae, Ji-Eun Kim, Hye-Young Jang, Jeung-Gon Kim, Jun-Gi Jang, Sung-Kil Hong, Tae-Yoon Park, Dae-Woong Lee
-
Publication number: 20110152339Abstract: The invention provides methods for the treatment of cancer in a subject comprising administering a dansyl-carbazole compound.Type: ApplicationFiled: August 14, 2009Publication date: June 23, 2011Inventors: Milton L. Brown, Kathryn D. Sheikh, Mikell A. Paige, Partha Banerjee, Shankar Jagadeesh
-
Publication number: 20110127495Abstract: The present invention provides a novel compound that is capable of largely improving life span, efficiency, electrochemical stability and thermal stability of the organic light emitting device, and an organic light emitting device in which said compound is included in an organic compound layer.Type: ApplicationFiled: November 7, 2008Publication date: June 2, 2011Inventors: Sung-Kil Hong, Wook-Dong Cho, Jae-Soon Bae, Ji-Eun Kim, Hyun Nam, Jun-Gi Jang, Byung-Sun Jeon, Mun-Kyu Joo, Hye-Young Jang
-
Publication number: 20110124879Abstract: The present invention provides a novel stable amorphous form of carvedilol dihydrogen phosphate and the process for its preparation that involves reaction of carvedilol base with ortho phosphoric acid in the presence of stabilizer in a suitable solvent or mixture of solvents followed by concentration and isolation. An alternate process for preparation of amorphous form of carvedilol dihydrogen phosphate involves addition of stabiliser to the solution of stable amorphous or crystalline carvedilol dihydrogen phosphate in a suitable solvent or mixture of solvents followed by concentration and isolation. The novel stable amorphous form of carvedilol dihydrogen phosphate is highly stable.Type: ApplicationFiled: August 6, 2008Publication date: May 26, 2011Applicant: Lupin LimitedInventors: Rajesh Kumar Thaper, Manoj Devilalji Prabhavat, Yogesh Dadaji Pawar, Pritesh R. Upadhyay
-
Publication number: 20110118303Abstract: The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.Type: ApplicationFiled: April 9, 2009Publication date: May 19, 2011Applicants: EMS S.A., Universidade Estadual Paulista Julio De Mesquita Filho - UNESPInventors: Ednir de Oliveira Vizioli, Chung Man Chin, Renato Farina Menegon, Lorena Blau, Jean Leandro Dos Santos, Maria do Carmo Longo
-
Publication number: 20110115368Abstract: The present invention provides an arylamine compound having a molecular weight of from 1500 to 6000 represented by the general formula (1): According to the present invention, there can be provided an arylamine compound having excellent hole injection and transporting characteristics and being capable of forming a stable thin film. By using the compound, emission efficiency and durability of conventional organic EL devices can remarkably be improved.Type: ApplicationFiled: November 18, 2010Publication date: May 19, 2011Applicant: Hodogaya Chemical Co., Ltd.Inventors: Tetsuzo MIKI, Naohiro Tarumoto, Yoshio Taniguchi, Musubu Ichikawa
-
Publication number: 20110118296Abstract: The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.Type: ApplicationFiled: July 2, 2009Publication date: May 19, 2011Inventors: Gordon W. Gribble, Dmity A. Kolpino
-
Publication number: 20110108823Abstract: The present invention relates to aromatic amines and to electronic devices in which these amines are used, in particular, as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.Type: ApplicationFiled: September 10, 2009Publication date: May 12, 2011Applicant: MERCK PATENT GMBHInventors: Philipp Stoessel, Holger Heil, Dominik Joosten, Christof Pflumm, Anja Gerhard
-
Publication number: 20110104305Abstract: Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.Type: ApplicationFiled: June 30, 2010Publication date: May 5, 2011Inventors: Brian J. DAY, Remy KACHADOURIAN
-
Publication number: 20110091382Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.Type: ApplicationFiled: February 17, 2009Publication date: April 21, 2011Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Qianwa Liang, Brian A. Duclos, Wei Zhang, Peter J.H. Scott, Kai Chen, Zhiyong Gao, Tieming Zhao, Vani P. Mocharla, Dhanalakshmi Kasi, Gang Chen, Eric Wang, Anjana Sinha, Chunfang Xia, Henry Clifton Padgett, Farhad Karimi
-
Patent number: 7919654Abstract: Provided are a cyclopentaphenanthrene-based compound and an organic EL device using the same. The cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, and color stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, a light-emitting layer in an organic EL device, and as an organic dye or an electronic material such as a nonlinear optical material.Type: GrantFiled: August 4, 2010Date of Patent: April 5, 2011Assignee: Samsung Mobile Display Co., Ltd.Inventors: Sang-Hoon Park, Che-Un Yang, Jong-Jin Park, Jhun-Mo Son, O-Hyun Kwon, Yu-Jin Kim
-
Patent number: 7919500Abstract: The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, wherein the rings are linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.Type: GrantFiled: July 8, 2009Date of Patent: April 5, 2011Assignee: Trustees of Dartmouth CollegeInventors: Gordon W. Gribble, Dmitry A. Androsov
-
Publication number: 20110077407Abstract: A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided. The methods may be used to make functional polymers and other molecules. The method of making a functionalized polymer using a thiol-ene reaction comprises: providing a functionalized thioester having the following formula: wherein R is a functional group and COR? is a protecting group; cleaving the functionalized thioester, forming a functional thiol and an acyl group; providing a polymer having a pendant vinyl group; and reacting the polymer with the functional thiol whereby a functionalized polymer is formed, wherein the functional thiol is not isolated prior to reacting with the polymer.Type: ApplicationFiled: December 6, 2010Publication date: March 31, 2011Inventors: Ralph L. David, Julia A. Kornfield
-
Publication number: 20110063485Abstract: A photoelectric conversion device comprising a transparent electrically conductive film, a photoelectric conversion film and an electrically conductive film in this order, wherein the photoelectric conversion film comprises a photoelectric conversion layer, and an electron blocking layer, wherein the electron blocking layer contains a compound represented by the specific formula.Type: ApplicationFiled: September 8, 2010Publication date: March 17, 2011Applicant: FUJIFILM CORPORATIONInventors: Kimiatsu NOMURA, Eiji FUKUZAKI, Tetsuro MITSUI
-
Publication number: 20110060025Abstract: The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.Type: ApplicationFiled: May 11, 2009Publication date: March 10, 2011Applicant: AZIENDE CHIM. RIUN.ANG.FRANC. A.C.R.A.F S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Isabella Coletta, Patrizia Dragone, Guido Furlotti, Barbara Garofalo, Angelo Guglielmotti, Giorgina Mangano, Caterina Maugeri
-
Patent number: 7902378Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.Type: GrantFiled: June 25, 2007Date of Patent: March 8, 2011Assignee: SmithKline Beecham (Cork) LimitedInventors: Christopher S. Brook, Wei Chen, Philip C. Dell'Orco, Lee M. Katrincic, Ann Marie Louvet, Choon K. Oh, Paul G. Spoors, Christopher Werner
-
Publication number: 20110046378Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's DiseaseType: ApplicationFiled: February 17, 2009Publication date: February 24, 2011Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Qianwa Liang, Brian A. Duclos, Wei Zhang, Peter J.H. Scott, Kai Chen, Zhiyong Gao, Tieming Zhao, Vani P. Mocharla, Dhanalakshmi Kasi, Gang Chen, Eric Wang, Anjana Sinha, Chunfang Xia, Henry Clifton Padgett, Farhad Karimi
-
Publication number: 20110042654Abstract: Disclosed is an organic compound represented by the following Chemical Formula 1 that easily dissolves in an organic solvent, and that is applicable as a host material of an emission layer of an organic photoelectric device since it emits fluorescence and phosphorescence at a red wavelength through a blue wavelength.Type: ApplicationFiled: March 12, 2010Publication date: February 24, 2011Inventors: Sung-Hyun Jung, Hyung-Sun Kim, Ho-Jae Lee, Eun-Sun Yu, Mi-Young Chae
-
Patent number: 7893100Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.Type: GrantFiled: June 25, 2007Date of Patent: February 22, 2011Assignee: SB Pharmco Puerto Rico Inc.Inventors: Christopher S. Brook, Wei Chen, Philip C. Dell'Orco, Lee M. Katrincic, Ann Marie Louvet, Choon K. Oh, Paul G. Spoors, Christopher Werner
-
Publication number: 20110039802Abstract: The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, R2 is hydrogen, lower alkyl or the like, n is 1 or 2, X is lower alkylone, lower alkenylene, arylene, cycloalkylene or the like, Y is CONR7, CSNR7, NR7CO, NR7CS or the like, Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like and R7 is hydrogen or lower alkyl, prodrug, pharmaceutically acceptable salt or solvate thereofType: ApplicationFiled: July 2, 2010Publication date: February 17, 2011Inventors: Yasuyuki KAWANISHI, Hideyuki TAKENAKA, Kohji HANASAKI, Tetsuo OKADA
-
Publication number: 20110031484Abstract: A condensed-cyclic compound represented by Formula 1 and an organic light emitting diode including the same:Type: ApplicationFiled: August 9, 2010Publication date: February 10, 2011Applicant: Samsung Mobile Display Co., Ltd.Inventors: Kwan-Hee Lee, Mi-Kyung Kim, Seung-Gak Yang
-
Patent number: 7879900Abstract: A compound of formula (I), in which R1, R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.Type: GrantFiled: July 25, 2006Date of Patent: February 1, 2011Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Patrizia Dragone, Guido Furlotti, Nicola Cazzolla, Vincenzo Russo, Giorgina Mangano, Isabella Coletta, Lorenzo Polenzani
-
Patent number: 7879893Abstract: The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NH2 or a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.Type: GrantFiled: September 13, 2002Date of Patent: February 1, 2011Assignee: Novo Nordisk A/SInventors: Helle Birk Olsen, Niels C. Kaarsholm, Peter Madsen, Soren Ostergaard, Svend Ludvigsen, Palle Jakobsen, Anders Klarskov Petersen, Dorte Bjerre Steensgaard
-
Patent number: 7879464Abstract: The present invention provides an anthracene derivative represented by the following general formula (1). In the general formula (1), R1 and R2 individually represent hydrogen or an alkyl group having 1 to 4 carbon atoms, and at least one of R1 and R2 is hydrogen. Further, R3 represents an aryl group having 6 to 15 carbon atoms. R4 represents hydrogen, an alkyl group having 1 to 4 carbon atoms, or an aryl group having 6 to 15 carbon atoms. R5 represents hydrogen, an alkyl group having 1 to 4 carbon atoms, or an aryl group having 6 to 15 carbon atoms. R6 represents an aryl group having 6 to 15 carbon atoms. X1 represents an arylene group having 6 to 15 carbon atoms. General formula (1) is inserted.Type: GrantFiled: July 20, 2006Date of Patent: February 1, 2011Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Sachiko Kawakami, Harue Nakashima, Kumi Kojima, Ryoji Nomura, Nobuharu Ohsawa
-
Patent number: 7875730Abstract: The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5%) having individual impurity less than 0.1%. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol.Type: GrantFiled: February 22, 2005Date of Patent: January 25, 2011Assignee: Cadila Healthcare Ltd.Inventors: Dhiraj R. Shah, Ashish P. Naik, Parva Y. Purohit, Rajivkumar Sharma, Virendra K. Agarwal
-
Publication number: 20110015247Abstract: The present patent application relates to a novel crystalline form (Form S) of Carvedilol dihydrogen phosphate and a process for its preparation. It also relates to an improved process for the preparation of Carvedilol dihydrogen phosphate.Type: ApplicationFiled: August 26, 2008Publication date: January 20, 2011Applicant: SHODHANA LABORATORIES LIMITEDInventors: Giridhar Thota, Srinivasulu Gudipati, Srinivasa Rao Kotaru