Chalcogen Or Nitrogen Attached Indirectly To Ring Nitrogen Of The Five Membered Hetero Ring By Acyclic Nonionic Bonding Patents (Class 548/449)
  • Patent number: 5047539
    Abstract: Heterocyclic amidine derivatives of the general formula I ##STR1## in which the variables R.sup.1 are the same or different and denote hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, hydroxyl or chlorine,R.sup.2 to R.sup.5 denote hydrogen or C.sub.1 -C.sub.4 -alkyl and R.sup.3 and R.sup.4 can together form a five-membered or six-membered ring,R.sup.6 denotes hydrogen or C.sub.1 -C.sub.8 -alkyl,R.sup.7 denotes cyano or --COOR.sup.8, --COR.sup.8, --CONHR.sup.8 or --CONR.sup.8.sub.2, in whichR.sup.8 is a straight-chain or branched-chain C.sub.1 -C.sub.12 -alkyl group which may be interrupted by oxygen atoms, a cyclopentyl or cyclohexyl group or a phenylalkyl group having from 1 to 3 carbon atoms in the alkyl moiety,A is a chemical bond or a methylene group which may additionally carry one or two C.sub.1 -C.sub.4 -alkyl radicals, andm and n are each 1 or 2.The said heterocyclic amidine derivatives I serve as UV stabilizers for organic materials.
    Type: Grant
    Filed: April 19, 1990
    Date of Patent: September 10, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Spang, Peter Neumann, Hubert Trauth
  • Patent number: 5039670
    Abstract: Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.
    Type: Grant
    Filed: October 17, 1990
    Date of Patent: August 13, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Muller, Ulrich Rosentreter, Erwin Bischoff, Volker-Bernd Fiedler, Elisabeth Perzborn, Joachim Hutter, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis, Marie G. McKenniff
  • Patent number: 4965258
    Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antoganize thromboxane A.sub.2.
    Type: Grant
    Filed: November 28, 1989
    Date of Patent: October 23, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4904797
    Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: February 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4827032
    Abstract: Cycloalkanol[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: May 2, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4546193
    Abstract: This invention provides a group of antiarrhythmic agents of the formula: ##STR1## in which R.sub.1 is --CO.sub.2 H, --CO.sub.2 (CH.sub.2).sub.n --NR.sub.4 R.sub.5, --CONR.sub.6 R.sub.7, --NHCO.sub.2 R.sub.8 or --NHCO.sub.2 (CH.sub.2).sub.o --NR.sub.9 R.sub.10 where R.sub.4 and R.sub.5 are H or alkyl of 1 to 6 carbon atoms and n is 1 to 6; R.sub.6 and R.sub.7 are H or alkyl of 1 to 6 carbon atoms; R.sub.8 is alkyl of 1 to 6 carbon atoms; and R.sub.9 and R.sub.10 are alkyl of 2 to 6 carbon atoms and o is 1 to 6;R.sub.2 and R.sub.3 are, independently, hydrogen or alkyl of 1 to 6 carbon atoms; andm is one of the integers 1, 2, 3 or 4;or a pharmaceutically acceptable salt thereof, and a method for their use.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: October 8, 1985
    Assignee: American Home Products Corporation
    Inventors: Magid A. Abou-Gharbia, Meier E. Freed, Thomas J. Colatsky
  • Patent number: 4485240
    Abstract: In a process for the preparation of optionally-substituted 1,2,3,4-tetrahydro-9-cyanomethylcarbazol-1-ones of the formula ##STR1## wherein R denotes hydrogen, halogen, alkyl or alkoxy, by cyano-methylating optionally substituted 1,2,3,4-tetrahydrocarbazol-1-ones of the formula ##STR2## wherein R has the meanings mentioned above, the starting material of formula II is reacted, in a two-phase system consisting of water and a water-immiscible organic solvent, in the presence of a strong base and a known phase transfer catalyst, with a cyanomethylating agent of the formulaR.sup.1 --CH.sub.2 --CN (III),wherein R.sup.1 denotes halogen or a radical of the formula R.sup.2 --SO.sub.2 --O-- and R.sup.2 represents alkyl, phenyl or substituted phenyl.
    Type: Grant
    Filed: April 19, 1983
    Date of Patent: November 27, 1984
    Assignee: Cassella Aktiengesellschaft
    Inventors: Heinz Bender, Veit Buch, Rudi Beyerle, Klaus Kuhlein