Ring Carbon Of Each Of The Two Five-membered Hetero Rings Is Bonded Directly To Chalcogen Or Nitrogen (e.g., Both Rings May Be Bonded To The Same Nitrogen Atom Or To Different Nitrogen Atoms, Etc.) Patents (Class 548/460)
  • Patent number: 4865650
    Abstract: Composition of matter containing:(a) a compound of the formula I ##STR1## in which A is one of the groups of the formulae ##STR2## in which B is --O--, --S--, --SO.sub.2 --, --N.dbd.N--, --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 --O-- ##STR3## --CONH--, --NHCONH-- or --CONHNHCO--, Q is --O' or --NH' and Z is --O-- or --S-- and R and R' are independently of each other hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or phenoxy, and (b) a compound of the formula II ##STR4## in which X.sup..sym. is H.sup..sym. or a group of the formulae ##EQU1## or N.sup..sym. (R.sub.1) (R.sub.2) (R.sub.3) (R.sub.4), M.sup.n.sym. is an n-valent metal cation, n is 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently of one another hydrogen, C.sub.1 -C.sub.18 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl, unsubstituted or C.sub.1 -C.sub.18 -alkyl-substituted phenyl or R.sub.3 and R.sub.4 together with the N atom form a pyrrolidine, imidazolidine, piperidine, piperazine or morpholine radical, or R.sub.
    Type: Grant
    Filed: December 16, 1987
    Date of Patent: September 12, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Jost von der Crone, Bernhard Medinger, Philippe Bugnon
  • Patent number: 4839367
    Abstract: Provided are antihypertensive compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the same or different,m is an integer from 0 to 2 inclusive,n is an integer from 0 to 4 inclusive,M is alkyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl,Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is alkyl, aryl, aralkyl, cycloalkyl, cycloalkyl-alkyl, heterocyclic, --CO--SR, --CS--SR, ##STR2## CH.sub.2 CO.sub.R, --CHM--CO.sub.2 R, --CH.sub.2 --CO--SR, --CN, ##STR3## --CO--NH--CH.sub.2 CO.sub.2 R, ##STR4## or --CO--CO.sub.2 CO.sub.
    Type: Grant
    Filed: August 11, 1986
    Date of Patent: June 13, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Raymond D. Youssefyeh, Howard Jones
  • Patent number: 4801702
    Abstract: A process for the preparation and conditioning of organic pigments, which comprises the use of at least one tricyclodecane alcohol or tricyclodecene alcohol.
    Type: Grant
    Filed: October 30, 1986
    Date of Patent: January 31, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Fridolin Babler
  • Patent number: 4707553
    Abstract: A 5-hydroxy-N-substituted indole derivative and the process for producing the indole derivative are described the indole derivative is produced by a process comprising reacting a phenol derivative having an unsaturated double bond in the m-position with a diazonium salt.
    Type: Grant
    Filed: December 28, 1984
    Date of Patent: November 17, 1987
    Assignee: Fuji Photo Film Co., Ltd.
    Inventor: Masato Satomura
  • Patent number: 4707548
    Abstract: Novel bisisoindoline pigments of the formula (I) ##STR1## where the radicals A are identical or different radicals of a methylene-active compound, X is a divalent radical and the rings L are each unsubstituted or substituted, possess good fastness properties and are therefore suitable for a very wide range of applications, for example for pigmenting plastics, printing inks and surface coatings.
    Type: Grant
    Filed: January 24, 1986
    Date of Patent: November 17, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Lotsch, Gustav Bock, Peter Neumann
  • Patent number: 4668799
    Abstract: A 1,3-dithiol-2-ylidene derivative of the formula: ##STR1## wherein each of R and R.sup.1 which may be the same or different, is a lower alkyl group, a lower alkenyl group, a cycloalkyl group, a lower alkoxyalkyl group, or a substituted or unsubstituted aryl, aralkyl or heterocyclic group, or R and R.sup.1 together form a substituted or unsubstituted ethylene or trimethylene group.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: May 26, 1987
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Junji Yoshizawa, Yoshimi Tsuchiya, Yukio Hirayama, Kaoru Shimada, Nobuyuki Mino, Kyoko Nakamichi, Ikuo Matsumoto
  • Patent number: 4567048
    Abstract: A series of novel water-soluble sulfonated indoxyl derivatives have been prepared, including their base salts with pharmacologically acceptable cations. These particular compounds are useful as food dyes or as cosmetic colorants. 2,2'-(1,4-phenylenedimethylidyne)-bis(2,3-dihydro-3-oxo-1H-indole-5-sulfon ic acid) represents a typical and preferred member compound. Methods for preparing these compounds are provided.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: January 28, 1986
    Assignee: Pfizer Inc.
    Inventor: Gordon D. Gruetzmacher
  • Patent number: 4558148
    Abstract: There are described fluorinated allylic compounds as expressed by the following general formula ##STR1## wherein R.sub.f is a fluorinated aliphatic group and R is a group expressed by a general formula ##STR2## wherein R.sup.1 is an aliphatic or aromatic hydrocarbon group and R.sup.2 and R.sup.3 are the same group or different groups as selected among hydrogen atom, aliphatic and aromatic hydrocarbon groups, and heterocyclic groups. Further, a process of preparing fluorinated allylic compounds is described which includes a process step wherein a silane metal halide as expressed by a general formula(R.sup.1).sub.3 SiCH.sub.2 MX,wherein R.sup.1 is either an aliphatic or aromatic hydrocarbon group, M is an element that belongs to the group IIa, IIIb, or VIIb of the periodic table, and X is a halogen atom, is reacted with a fluorinated carboxylic acid ester as expressed by a general formulaR.sub.f COOR',wherein R.sub.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: December 10, 1985
    Assignee: Daikin Industries Ltd.
    Inventors: Nobuo Ishikawa, Tomoya Kitazume
  • Patent number: 4495352
    Abstract: 1-Aryloxy-3-[(3-indolyl)-tert.-butyl]amino-2-propanols having a heterocyclic aryl-attached substituent or aryl-fused heterocyclic ring are antihypertensive agents having vasodilator and adrenergic .beta.-receptor blocking action.
    Type: Grant
    Filed: December 3, 1981
    Date of Patent: January 22, 1985
    Assignee: Mead Johnson & Company
    Inventors: William E. Kreighbaum, William T. Comer
  • Patent number: 4338316
    Abstract: The disclosure relates to 9.beta.-aryloxy prostane derivatives, for example 16-(3-chlorophenoxy)-11.alpha.,15.alpha.-dihydroxy-16-methyl-9.beta.-pheno xy-18,19,20-trinor-5-cis,13-trans-prostadienoic acid, which possess high activity as abortifacients, cervical softeners, inducers of parturition or inhibitors of gastric acid production in mammals. These properties are typical of prostaglandin analogues of the E series, but chemically the new 9.beta.-aryloxy prostane derivatives are prostaglandin F series analogues and are therefore more stable than the E series analogues previously used for the above purposes. The new derivatives are manufactured by known analogy processes, and are formulated in conventional manner.
    Type: Grant
    Filed: September 26, 1979
    Date of Patent: July 6, 1982
    Assignee: Imperial Chemical Industries Limited
    Inventor: Peter R. Marsham