Polycyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/15)
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Patent number: 11028277Abstract: A charge transport varnish containing a charge transport substance, an electron-accepting dopant substance, and an organic solvent, wherein the electron-accepting dopant substance contains one or more types selected from naphthalene disulfonic acid, naphthalene trisulfonic acid, and naphthalene tetrasulfonic acid. This charge transport varnish is suitable for forming a hole collection layer that can be used to produce an organic photoelectric conversion element which exhibits high photoelectric conversion efficiency.Type: GrantFiled: January 25, 2017Date of Patent: June 8, 2021Assignee: NISSAN CHEMICAL CORPORATIONInventors: Juro Oshima, Takuji Yoshimoto
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Patent number: 10428042Abstract: An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol. (In the formula, each of R1a and R1b is a hydrogen atom or a hydroxy protective group; R2 is a hydroxy group or the like; and R3 is a hydroxy group or the like.Type: GrantFiled: July 24, 2018Date of Patent: October 1, 2019Assignee: FUJIFILM CorporationInventors: Koki Nakamura, Hisato Nagase, Yuuta Fujino, Katsuyuki Watanabe, Taiji Katsumata
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Patent number: 10059686Abstract: An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol. (In the formula, each of R1a and R1b is a hydrogen atom or a hydroxy protective group; R2 is a hydroxy group or the like; and R3 is a hydroxy group or the like.).Type: GrantFiled: September 20, 2017Date of Patent: August 28, 2018Assignee: FUJIFILM CorporationInventors: Koki Nakamura, Hisato Nagase, Yuuta Fujino, Katsuyuki Watanabe, Taiji Katsumata
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Patent number: 9802913Abstract: An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol. (In the formula, each of R1a and R1b is a hydrogen atom or a hydroxy protective group; R2 is a hydroxy group or the like; and R3 is a hydroxy group or the like.Type: GrantFiled: September 19, 2016Date of Patent: October 31, 2017Assignee: FUJIFILM CorporationInventors: Koki Nakamura, Hisato Nagase, Yuuta Fujino, Katsuyuki Watanabe, Taiji Katsumata
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Publication number: 20150148314Abstract: There are provided, inter alia, derivatives of seriniquinone and methods useful for the treatment of cancer, and in particular treatment of melanoma and prostate cancer.Type: ApplicationFiled: January 27, 2015Publication date: May 28, 2015Inventors: William Fenical, Paul R. Jensen, James J. La Clair, Lynnie Trzoss, Takashi Fukuda
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Publication number: 20150137111Abstract: A compound for an organic optoelectronic device, an organic light-emitting device including the same and a display device including the organic light-emitting device are provided, and the compound for an organic optoelectronic device represented by a combination of the following Chemical Formulae 1 and 2 is provided and thus an organic light-emitting device has improved life-span characteristics due to excellent electrochemical and thermal stability, and high luminous efficiency at a low driving voltage.Type: ApplicationFiled: January 30, 2015Publication date: May 21, 2015Inventors: Dong-Wan RYU, Nam-Heon LEE, Han-Ill LEE, Sung-Hyun JUNG, Young-Kyoung JO, Mi-Young CHAE, Dal-Ho HUH, Jin-Seok HONG
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Patent number: 8980134Abstract: Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation and/or are able to reduce the surface energy of organic materials comprise at least one compound of the formula (I) wherein the general symbols are as defined in claim 1.Type: GrantFiled: March 31, 2009Date of Patent: March 17, 2015Assignee: BASF SEInventors: Michèle Gerster, Manuel Mihalic
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Publication number: 20140359951Abstract: An agent for oxidative coloring of keratin-containing fibers, in particular human hair, includes as oxidation dye precursor of the developer type at least one compound of formula (I).Type: ApplicationFiled: August 22, 2014Publication date: December 11, 2014Inventors: Antje Gebert, Annika Koenen
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Publication number: 20140243349Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.Type: ApplicationFiled: February 21, 2014Publication date: August 28, 2014Inventors: Sunil Kumar KC, David Mark Wallace, John Hood, Charlene F. Barroga
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Patent number: 8691931Abstract: Polymers which can be used in p-type materials for organic electronic devices and photovoltaic cells. Compounds, monomers, dimers, trimers, and polymers comprising: wherein A1 and A2 each independently comprise a fused ring system comprising at least two fused rings directly covalently linked to the pyrrole rings. Good photovoltaic efficiency and lifetime can be achieved. The R group can provide solubility, environmental stability, and fine tuning of spectroscopic and/or electronic properties. Different polymer microstructures can be prepared which encourage multiple band gaps and broad and strong absorptions. The carbonyl can interact with adjacent thiophene rings to provide backbone with rigidity, induce planarity, and reduce and/or eliminate intramolecular chain twisting defects.Type: GrantFiled: September 1, 2010Date of Patent: April 8, 2014Assignee: Plextronics, Inc.Inventors: Christopher T. Brown, Christophe René Gaston Grenier, Chad Landis, Elena E. Sheina, Ting Xu
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Publication number: 20140080703Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.Type: ApplicationFiled: November 18, 2013Publication date: March 20, 2014Applicant: BayerCrop Science AGInventors: Thomas Seitz, Jurgen Benting, Ulrike Wachendorff-Neumann
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Publication number: 20140054520Abstract: A novel photochromic compound which develops a color of a neutral tint and has high color optical density, high fading speed and excellent durability. The present invention is a chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as the basic skeleton in which a hetero ring having two hetero atoms including at least one sulfur atom is directly bonded to the 6-position and the 7-position of the indeno(2,1-f)naphtho(1,2-b)pyran structure via the hetero atom like the compound represented by the following formula (18).Type: ApplicationFiled: March 7, 2012Publication date: February 27, 2014Applicant: TOKUYAMA CORPORATIONInventors: Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Toshiaki Takahashi, Mitsuyoshi Sando, Shinobu Izumi
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Publication number: 20140031388Abstract: Anticancer compounds according to formula I are described herein. wherein R1, R2, R3 and R4 are selected from H, CH3, OH, SH, OCH3, NHR?, halogen, CF3, N-linked pyrrolidine, and SO2NHR?, or any combination thereof; R5 is an alkyl, alkenyl, or alkaryl group including from 4 to 11 carbons, X is selected from CH2, CHOH, C?O, S?O, O?S?O, and an oxetane ring, Y is selected from CH2, O, and NH, and R? is a H, aryl, or a lower alkyl group, or pharmaceutically acceptable salts thereof. The compounds have been shown to facilitate site-specific dephosphorylation of Akt at Ser-473, thereby inactivating Akt and decreasing dysregulation of Akt signaling that can occur in cancer cells.Type: ApplicationFiled: July 26, 2013Publication date: January 30, 2014Inventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
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Publication number: 20130296315Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.Type: ApplicationFiled: March 11, 2013Publication date: November 7, 2013Inventor: Bayer CropScience AG
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Patent number: 8563779Abstract: A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.Type: GrantFiled: July 19, 2011Date of Patent: October 22, 2013Assignee: Bayer CropScience AGInventors: Hartmut Ahrens, Andreas Van Almsick, Elmar Gatzweiler, Dieter Feucht, Isolde Haeuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
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Patent number: 8471019Abstract: A semiconducting layer comprising a non-polymeric quinoid heteroacene compound of the formula (I) wherein X stands for O, S or NR, each of R, R1, R2, R3, R4, R5, R6, R7, R8 being independently selected from hydrogen and an organic residue, or 2 or more thereof together forming one or more annealed rings, which may be substituted or unsubstituted, carbocyclic or helerocyclic, aromatic, quinoid or aliphatic, may be used e.g. for the manufacture of a diode, an organic field effect transistor, an organic thin film transistor, or a device containing a diode and/or an organic field effect transistor and/or organic thin film transistor.Type: GrantFiled: April 4, 2007Date of Patent: June 25, 2013Assignee: BASF SEInventors: Ulrich Berens, Arno Stassen, Beat Schmidhalter, Wolfgang Kalb, Frank Bienewald
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Patent number: 8440842Abstract: The present invention relates to compounds of Formula (I) or salts thereof wherein R1, R2, R3, R4, R5, R6, and other variables enumerated under one or more of same are as defined herein. Compounds of Formula I have activity as antimicrobial agents. Also disclosed are pharmaceutical compositions and methods of treating and preventing microbial infections in mammals, for example, a tuberculosis or leprosy infection, which employ compounds of Formula (I) or salts thereof.Type: GrantFiled: June 25, 2008Date of Patent: May 14, 2013Assignee: Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knoell-InstitutInventors: Ute Moellmann, Vadim Makarov, Cole T. Stewart
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Patent number: 8383551Abstract: The present invention relates to new thienodithiine derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these thienodithiine derivatives.Type: GrantFiled: April 14, 2011Date of Patent: February 26, 2013Assignee: Bayer CropScience AGInventors: Thomas Seitz, Jürgen Benting, Ulrike Wachendorff-Neumann
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Patent number: 8309598Abstract: A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is selected from H and OMe, R2 is selected from OH, OMe and OEt, and R3 is selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.Type: GrantFiled: December 19, 2008Date of Patent: November 13, 2012Assignee: Givaudan S.A.Inventor: David C. Bom
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Patent number: 8163770Abstract: Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.Type: GrantFiled: October 25, 2006Date of Patent: April 24, 2012Assignee: MSD. K. K.Inventors: Takashi Mizutani, Nagaaki Sato, Takahide Sasaki, Toshiyuki Takahashi
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Patent number: 8119820Abstract: A method of preparing a sultine from a dihalogeno compound. The method comprises the steps of reacting the dihalogeno compound with a hydroxymethanesulfinate salt in a DMSO solvent so as to prepare the sultine.Type: GrantFiled: January 27, 2011Date of Patent: February 21, 2012Assignee: Silverbrook Research Pty LtdInventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley
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Publication number: 20120035364Abstract: A tetrathiafulvalene derivative expressed by General Formula (I): General Formula (I) in General Formula (I), X represents an atom selected from a carbon atom, a sulfur atom, and a nitrogen atom, and Xs may be the same or different; provided that when X is the carbon atom or the nitrogen atom, R1 to R8 each represent one of a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, and a substituted or unsubstituted thioalkoxy group, and may be the same or different; and Y1 and Y2 each represent one of structures expressed by General Formulas (II) and (III), and may be the same or different: General Formula (II) General Formula (III).Type: ApplicationFiled: March 17, 2010Publication date: February 9, 2012Inventors: Masato Shinoda, Satoshi Yamamoto, Toshiya Sagisaka, Takuji Kato, Takashi Okada, Daisuke Goto, Shinji Matsumoto, Masataka Mohri
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Publication number: 20110309307Abstract: The present invention relates to the use of heterocyclic compounds as the charge transport material, blocker material or light-scattering material in electronic, optoelectronic or electroluminescent components.Type: ApplicationFiled: December 14, 2009Publication date: December 22, 2011Applicant: NOVALED AGInventors: Olaf Zeika, Horst Hartmann, Ulrich Heggemann, Sascha Dorok, Jan Blochwitz-Nimoth, Ansgar Werner, Michael Hofmann, Carsten Rothe
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Publication number: 20110294662Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.Type: ApplicationFiled: April 14, 2011Publication date: December 1, 2011Applicant: Bayer CropScience AGInventors: Thomas SEITZ, Jürgen Benting, Ulrike Wachendorff-Neumann
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Publication number: 20110294785Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.Type: ApplicationFiled: August 21, 2009Publication date: December 1, 2011Applicant: The Trustees of the University of PennsylvaniaInventors: William F. DeGrado, Jun Wang
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Publication number: 20110281915Abstract: The present invention relates to new thienodithiine derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these thienodithiine derivatives.Type: ApplicationFiled: April 14, 2011Publication date: November 17, 2011Applicant: Bayer CropScience AGInventors: Thomas SEITZ, Jürgen Benting, Ulrike Wachendorff-Neumann
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Patent number: 8053576Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.Type: GrantFiled: February 17, 2009Date of Patent: November 8, 2011Assignee: Gruenenthal GmbHInventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
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Publication number: 20110160357Abstract: Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation and/or are able to reduce the surface energy of organic materials comprise at least one compound of the formula (I) wherein the general symbols are as defined in claim 1.Type: ApplicationFiled: March 31, 2009Publication date: June 30, 2011Applicant: BASF SEInventors: Michèle Gerster, Manuel Mihalic
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Patent number: 7951962Abstract: An organic semiconductor compound is represented by a general formula 1: wherein A and B each are an aromatic ring with a conjugated electron system and X and Y each are DR2, ER or G in which D denotes any of C, Si, Ge and Sn, E denotes any of N, P, As and Bi, G denotes any of O, S, Se and Te and R denotes any of H, an alkyl group and an aryl group.Type: GrantFiled: September 5, 2007Date of Patent: May 31, 2011Assignee: Seiko Epson CorporationInventors: Takao Nishikawa, Satoshi Ogawa
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Publication number: 20110124883Abstract: A method of preparing a sultine from a dihalogeno compound. The method comprises the steps of reacting the dihalogeno compound with a hydroxymethanesulfinate salt in a DMSO solvent so as to prepare the sultine.Type: ApplicationFiled: January 27, 2011Publication date: May 26, 2011Inventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley
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Publication number: 20110114184Abstract: Polymers which can be used in p-type materials for organic electronic devices and photovoltaic cells. Compounds, monomers, dimers, trimers, and polymers comprising: wherein A1 and A2 each independently comprise a fused ring system comprising at least two fused rings directly covalently linked to the pyrrole rings. Good photovoltaic efficiency and lifetime can be achieved. The R group can provide solubility, environmental stability, and fine tuning of spectroscopic and/or electronic properties. Different polymer microstructures can be prepared which encourage multiple band gaps and broad and strong absorptions. The carbonyl can interact with adjacent thiophene rings to provide backbone with rigidity, induce planarity, and reduce and/or eliminate intramolecular chain twisting defects.Type: ApplicationFiled: September 1, 2010Publication date: May 19, 2011Inventors: Christopher T. Brown, Christophe René Gaston Grenier, Chad Landis, Elena E. Sheina, Ting Xu
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Publication number: 20100283040Abstract: This invention is directed to selenophene compounds, selenophene-based polymers (polyselenophene), processes for the preparation of the same and uses thereof. The polyselenophenes of this invention have high conductivity and can be used as electrodes in various devices such as in electrochromic devices, batteries, solar cells, optical amplifiers, organic light emitting diodes, and the like.Type: ApplicationFiled: September 10, 2008Publication date: November 11, 2010Inventors: Michael Bendikov, Asit Patra, Yair-Haim Wijsboom, Mao Li, Yana Sheynin, Natalia Zamoshchik, Sanjio S. Zade
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Patent number: 7799931Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.Type: GrantFiled: February 17, 2009Date of Patent: September 21, 2010Assignee: Gruenenthal GmbHInventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
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Patent number: 7772409Abstract: A method of preparing a sultine of formula (V) from a dihalogeno compound of formula (IV) is provided. The method comprises reacting the dihalogeno compound (IV) with a hydroxymethanesulfinate salt in a DMSO solvent, wherein: R1, R2, R3 and R4 are each independently selected from hydrogen, hydroxyl, C1-20alkyl, C1-20alkoxy, amino, C1-20alkylamino, di(C1-20alkyl)amino, halogen, cyano, thiol, C1-20alkylthio, nitro, C1-20alkylcarboxy, C1-20alkylcarbonyl, C1-20alkoxycarbonyl, C1-20alkylcarbonyloxy, C1-20alkylcarbonylamino, C5-20aryl, C5-20arylalkyl, C5-20arylalkoxy, C5-20heteroaryl, C5-20heteroaryloxy, C5-20heteroarylalkoxy or C5-20heteroarylalkyl; and X is Cl, Br or I.Type: GrantFiled: August 1, 2007Date of Patent: August 10, 2010Assignee: Silverbrook Research Pty LtdInventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley, Kia Silverbrook
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Publication number: 20100168156Abstract: Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.Type: ApplicationFiled: October 25, 2006Publication date: July 1, 2010Inventors: Takashi Mizutani, Nagaaki Sato, Takahide Sasaki, Toshiyuki Takahashi
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Publication number: 20100160411Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided, wherein each of R1, R2, R3, R4, y, n, m, p, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.Type: ApplicationFiled: October 24, 2007Publication date: June 24, 2010Applicant: WyethInventors: Gary Paul Stack, Ivana Bianchi, Stefania Vallese, Giovanna Luoni
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Publication number: 20090163572Abstract: A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is selected from H and OMe, R2 is selected from OH, OMe and OEt, and R3 is selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.Type: ApplicationFiled: December 19, 2008Publication date: June 25, 2009Inventor: David C. Bom
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Publication number: 20090105166Abstract: The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as ?-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).Type: ApplicationFiled: August 21, 2007Publication date: April 23, 2009Inventors: Mark A. Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, David Vensel, Chiang J. Li
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Patent number: 7514461Abstract: The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: GrantFiled: September 15, 2004Date of Patent: April 7, 2009Assignee: Edison Pharmaceuticals, Inc.Inventors: Bing Wang, Gail Walkinshaw, Sekhar Boddupalli, Arkadij M. Elizarov, Xianming Jin, Xianfeng Li, Donald R. James, Jiangao Song, Jian Chen, Wei Zhang
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Publication number: 20090043108Abstract: A method of preparing a sultine of formula (V) from a dihalogeno compound of formula (IV) is provided. The method comprises reacting the dihalogeno compound (IV) with a hydroxymethanesulfinate salt in a DMSO solvent, wherein: R1, R2, R3 and R4 are each independently selected from hydrogen, hydroxyl, C1-20alkyl, C1-20alkoxy, amino, C1-20alkylamino, di(C1-20alkyl)amino, halogen, cyano, thiol, C1-20alkylthio, nitro, C1-20alkylcarboxy, C1-20alkylcarbonyl, C1-20alkoxycarbonyl, C1-20alkylcarbonyloxy, C1-20alkylcarbonylamino, C5-20aryl, C5-20arylalkyl, C5-20arylalkoxy, C5-20heteroaryl, C5-20heteroaryloxy, C5-20heteroarylalkoxy or C5-20heteroarylalkyl; and X is Cl, Br or I.Type: ApplicationFiled: August 1, 2007Publication date: February 12, 2009Inventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley, Kia Silverbrook
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Patent number: 7405308Abstract: Triarylsulfonium salts of formula I or II are useful as initiators for cationic photopolymerizations: wherein Ar1 and Ar2 are independently polycyclic aryl, substituted aryl, heteroaryl, substituted heteroaryl, or aryl or heteroaryl, pendant from a polymer chain; and MtXn? is a complex anion selected from PF6?, SbF6?, AsF6?, GaF6?, BF4?, (C6F5)4B? and CF3SO2)3C?.Type: GrantFiled: November 16, 2004Date of Patent: July 29, 2008Assignee: Rensselaer Polytechnic InstitueInventor: James V. Crivello
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Publication number: 20080105865Abstract: An object is to provide a pyrene based compound that is good in both properties of light emission and mobility when the compound is used as a light emitting transistor element; and a light emitting transistor element wherein this specific pyrene based compound is used. A pyrene based compound represented by the following chemical formula (1) is used as a main component of a light emitting layer in a light emitting transistor element: (wherein R1 represents a group selected from a heteroaryl group which may have a substituent, an aryl group which may have a substituent except a phenyl group which does not have any substituent, an alkyl group which may have a substituent and has a main chain having 1 to 20 carbon atoms, an alkenyl group which may have a substituent, an alkynyl group which may have a substituent, a silyl group which may have a substituent, and a halogen atom.Type: ApplicationFiled: November 25, 2005Publication date: May 8, 2008Inventors: Takahito Oyamada, Hiroyuki Uchiuzou, Chihaya Adachi, Seiji Akiyama, Takayoshi Takahashi
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Patent number: 7368567Abstract: Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, n, p, Ar, X, R1, R2, R3, R4, R5 and R6 are as defined herein. Also provided are compositions comprising, methods of preparing, and methods of using the subject compounds.Type: GrantFiled: May 4, 2005Date of Patent: May 6, 2008Assignee: Roche Palo Alto LLCInventors: Jacob Berger, Shu-Hai Zhao
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Patent number: 7301705Abstract: The alicyclic compound of the present invention has a five- or more membered ring structure having an epithioethylene linkage and/or an epidithioethylene linkage, and has tow or more sulfur atoms in its molecule. Optical materials produced by curing the alicyclic compound or a composition containing the alicyclic compound by polymerization show high refractive index.Type: GrantFiled: June 11, 2002Date of Patent: November 27, 2007Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Yuichi Yoshimura, Motoharu Takeuchi, Teruo Kamura
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Patent number: 7291742Abstract: A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid of formula (I), or a salt thereof, and the intermediates thereof, useful as an intermediate in the preparation of zonisamide.Type: GrantFiled: December 24, 2003Date of Patent: November 6, 2007Assignee: Dipharma S.p.A.Inventors: Gabriele Razzetti, Simone Mantegazza, Graziano Castaldi, Plietro Allegrini, Vittorio Lucchini, Alberto Bologna
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Patent number: 6998407Abstract: Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The compounds are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection.Type: GrantFiled: November 18, 2003Date of Patent: February 14, 2006Assignees: Telik, Inc., Sanwa Kagaku Kenkyusho Co. Ltd.Inventors: Edgardo Laborde, Louise Robinson, Fanying Meng, Brian T. Peterson, Hugo O. Villar, Steven E. Anuskiewicz, Yoshiro Ishiwata, Shoji Yokochi, Yukiharu Matsumoto, Takuji Kakigami, Hideaki Inagaki, Takahito Jomori, Kouji Matsushima
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Patent number: 6764777Abstract: The compound represented by the general formula (I): wherein each of R1 to R12 and RA1 to RA6 represents a hydrogen atom or a substituent group, and adjacent groups of R1 to R11 and RA1 to RA6 may be bonded to each other to form a ring. The light-emitting device of the present invention comprises a pair of electrodes and one or more organic layers disposed therebetween, at least one of the organic layers comprising the above compound.Type: GrantFiled: February 14, 2003Date of Patent: July 20, 2004Assignee: Fuji Photo Film Co., Ltd.Inventor: Toshihiro Ise
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Patent number: 6730697Abstract: Dihydrothiaphenanthrenecarbonylguanidine compound of formula I These compounds are potentially suitable as antiarrythmic medicaments with a cardioprotective component for prophylaxis of an infarction and treatment of infarction, and for treatment of angina pectoris. They may also inhibit in a preventive manner the pathophysiological processes involved in the development of ischemia-induced damage, especially in the initiation of ischemia-induced cardiac arrhythmias.Type: GrantFiled: January 23, 2003Date of Patent: May 4, 2004Assignee: Aventis Pharma Deutschland GmbHInventors: Heinz-Werner Kleemann, Peter Below
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Patent number: 6727258Abstract: The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection against hypoxia and ischemia induced injury and treatment of adenosine-sensitive cardiac arrhythmias.Type: GrantFiled: March 19, 2001Date of Patent: April 27, 2004Assignee: King Pharmaceutical Research & Development, Inc.Inventor: Pier Giovanni Baraldi
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Patent number: 6696540Abstract: An episulfide compound useful as a starting material for optical materials that have a high refractive index and a high Abbe's number is provided. A method for producing the same and an optical product made with the same are also provided. The episulfide compound may be represented by the general formula (1): wherein EP represents and n is an integer of from 0 to 2. A method for producing the episulfide compound represented by the general formula (1) may involve reacting a mercapto group-containing episulfide compound with 2,4,6-trimethylene-1,3,5-trithiane.Type: GrantFiled: November 20, 2002Date of Patent: February 24, 2004Assignee: Hoya CorporationInventors: Tsuyoshi Okubo, Ken Takamatsu