Polycyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/15)
  • Patent number: 11028277
    Abstract: A charge transport varnish containing a charge transport substance, an electron-accepting dopant substance, and an organic solvent, wherein the electron-accepting dopant substance contains one or more types selected from naphthalene disulfonic acid, naphthalene trisulfonic acid, and naphthalene tetrasulfonic acid. This charge transport varnish is suitable for forming a hole collection layer that can be used to produce an organic photoelectric conversion element which exhibits high photoelectric conversion efficiency.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 8, 2021
    Assignee: NISSAN CHEMICAL CORPORATION
    Inventors: Juro Oshima, Takuji Yoshimoto
  • Patent number: 10428042
    Abstract: An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol. (In the formula, each of R1a and R1b is a hydrogen atom or a hydroxy protective group; R2 is a hydroxy group or the like; and R3 is a hydroxy group or the like.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: October 1, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Koki Nakamura, Hisato Nagase, Yuuta Fujino, Katsuyuki Watanabe, Taiji Katsumata
  • Patent number: 10059686
    Abstract: An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol. (In the formula, each of R1a and R1b is a hydrogen atom or a hydroxy protective group; R2 is a hydroxy group or the like; and R3 is a hydroxy group or the like.).
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: August 28, 2018
    Assignee: FUJIFILM Corporation
    Inventors: Koki Nakamura, Hisato Nagase, Yuuta Fujino, Katsuyuki Watanabe, Taiji Katsumata
  • Patent number: 9802913
    Abstract: An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol. (In the formula, each of R1a and R1b is a hydrogen atom or a hydroxy protective group; R2 is a hydroxy group or the like; and R3 is a hydroxy group or the like.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: October 31, 2017
    Assignee: FUJIFILM Corporation
    Inventors: Koki Nakamura, Hisato Nagase, Yuuta Fujino, Katsuyuki Watanabe, Taiji Katsumata
  • Publication number: 20150148314
    Abstract: There are provided, inter alia, derivatives of seriniquinone and methods useful for the treatment of cancer, and in particular treatment of melanoma and prostate cancer.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 28, 2015
    Inventors: William Fenical, Paul R. Jensen, James J. La Clair, Lynnie Trzoss, Takashi Fukuda
  • Publication number: 20150137111
    Abstract: A compound for an organic optoelectronic device, an organic light-emitting device including the same and a display device including the organic light-emitting device are provided, and the compound for an organic optoelectronic device represented by a combination of the following Chemical Formulae 1 and 2 is provided and thus an organic light-emitting device has improved life-span characteristics due to excellent electrochemical and thermal stability, and high luminous efficiency at a low driving voltage.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 21, 2015
    Inventors: Dong-Wan RYU, Nam-Heon LEE, Han-Ill LEE, Sung-Hyun JUNG, Young-Kyoung JO, Mi-Young CHAE, Dal-Ho HUH, Jin-Seok HONG
  • Patent number: 8980134
    Abstract: Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation and/or are able to reduce the surface energy of organic materials comprise at least one compound of the formula (I) wherein the general symbols are as defined in claim 1.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: March 17, 2015
    Assignee: BASF SE
    Inventors: Michèle Gerster, Manuel Mihalic
  • Publication number: 20140359951
    Abstract: An agent for oxidative coloring of keratin-containing fibers, in particular human hair, includes as oxidation dye precursor of the developer type at least one compound of formula (I).
    Type: Application
    Filed: August 22, 2014
    Publication date: December 11, 2014
    Inventors: Antje Gebert, Annika Koenen
  • Publication number: 20140243349
    Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 28, 2014
    Inventors: Sunil Kumar KC, David Mark Wallace, John Hood, Charlene F. Barroga
  • Patent number: 8691931
    Abstract: Polymers which can be used in p-type materials for organic electronic devices and photovoltaic cells. Compounds, monomers, dimers, trimers, and polymers comprising: wherein A1 and A2 each independently comprise a fused ring system comprising at least two fused rings directly covalently linked to the pyrrole rings. Good photovoltaic efficiency and lifetime can be achieved. The R group can provide solubility, environmental stability, and fine tuning of spectroscopic and/or electronic properties. Different polymer microstructures can be prepared which encourage multiple band gaps and broad and strong absorptions. The carbonyl can interact with adjacent thiophene rings to provide backbone with rigidity, induce planarity, and reduce and/or eliminate intramolecular chain twisting defects.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: April 8, 2014
    Assignee: Plextronics, Inc.
    Inventors: Christopher T. Brown, Christophe René Gaston Grenier, Chad Landis, Elena E. Sheina, Ting Xu
  • Publication number: 20140080703
    Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 20, 2014
    Applicant: BayerCrop Science AG
    Inventors: Thomas Seitz, Jurgen Benting, Ulrike Wachendorff-Neumann
  • Publication number: 20140054520
    Abstract: A novel photochromic compound which develops a color of a neutral tint and has high color optical density, high fading speed and excellent durability. The present invention is a chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as the basic skeleton in which a hetero ring having two hetero atoms including at least one sulfur atom is directly bonded to the 6-position and the 7-position of the indeno(2,1-f)naphtho(1,2-b)pyran structure via the hetero atom like the compound represented by the following formula (18).
    Type: Application
    Filed: March 7, 2012
    Publication date: February 27, 2014
    Applicant: TOKUYAMA CORPORATION
    Inventors: Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Toshiaki Takahashi, Mitsuyoshi Sando, Shinobu Izumi
  • Publication number: 20140031388
    Abstract: Anticancer compounds according to formula I are described herein. wherein R1, R2, R3 and R4 are selected from H, CH3, OH, SH, OCH3, NHR?, halogen, CF3, N-linked pyrrolidine, and SO2NHR?, or any combination thereof; R5 is an alkyl, alkenyl, or alkaryl group including from 4 to 11 carbons, X is selected from CH2, CHOH, C?O, S?O, O?S?O, and an oxetane ring, Y is selected from CH2, O, and NH, and R? is a H, aryl, or a lower alkyl group, or pharmaceutically acceptable salts thereof. The compounds have been shown to facilitate site-specific dephosphorylation of Akt at Ser-473, thereby inactivating Akt and decreasing dysregulation of Akt signaling that can occur in cancer cells.
    Type: Application
    Filed: July 26, 2013
    Publication date: January 30, 2014
    Inventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
  • Publication number: 20130296315
    Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.
    Type: Application
    Filed: March 11, 2013
    Publication date: November 7, 2013
    Inventor: Bayer CropScience AG
  • Patent number: 8563779
    Abstract: A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: October 22, 2013
    Assignee: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Andreas Van Almsick, Elmar Gatzweiler, Dieter Feucht, Isolde Haeuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
  • Patent number: 8471019
    Abstract: A semiconducting layer comprising a non-polymeric quinoid heteroacene compound of the formula (I) wherein X stands for O, S or NR, each of R, R1, R2, R3, R4, R5, R6, R7, R8 being independently selected from hydrogen and an organic residue, or 2 or more thereof together forming one or more annealed rings, which may be substituted or unsubstituted, carbocyclic or helerocyclic, aromatic, quinoid or aliphatic, may be used e.g. for the manufacture of a diode, an organic field effect transistor, an organic thin film transistor, or a device containing a diode and/or an organic field effect transistor and/or organic thin film transistor.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: June 25, 2013
    Assignee: BASF SE
    Inventors: Ulrich Berens, Arno Stassen, Beat Schmidhalter, Wolfgang Kalb, Frank Bienewald
  • Patent number: 8440842
    Abstract: The present invention relates to compounds of Formula (I) or salts thereof wherein R1, R2, R3, R4, R5, R6, and other variables enumerated under one or more of same are as defined herein. Compounds of Formula I have activity as antimicrobial agents. Also disclosed are pharmaceutical compositions and methods of treating and preventing microbial infections in mammals, for example, a tuberculosis or leprosy infection, which employ compounds of Formula (I) or salts thereof.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: May 14, 2013
    Assignee: Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knoell-Institut
    Inventors: Ute Moellmann, Vadim Makarov, Cole T. Stewart
  • Patent number: 8383551
    Abstract: The present invention relates to new thienodithiine derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these thienodithiine derivatives.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: February 26, 2013
    Assignee: Bayer CropScience AG
    Inventors: Thomas Seitz, Jürgen Benting, Ulrike Wachendorff-Neumann
  • Patent number: 8309598
    Abstract: A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is selected from H and OMe, R2 is selected from OH, OMe and OEt, and R3 is selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: November 13, 2012
    Assignee: Givaudan S.A.
    Inventor: David C. Bom
  • Patent number: 8163770
    Abstract: Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: April 24, 2012
    Assignee: MSD. K. K.
    Inventors: Takashi Mizutani, Nagaaki Sato, Takahide Sasaki, Toshiyuki Takahashi
  • Patent number: 8119820
    Abstract: A method of preparing a sultine from a dihalogeno compound. The method comprises the steps of reacting the dihalogeno compound with a hydroxymethanesulfinate salt in a DMSO solvent so as to prepare the sultine.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: February 21, 2012
    Assignee: Silverbrook Research Pty Ltd
    Inventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley
  • Publication number: 20120035364
    Abstract: A tetrathiafulvalene derivative expressed by General Formula (I): General Formula (I) in General Formula (I), X represents an atom selected from a carbon atom, a sulfur atom, and a nitrogen atom, and Xs may be the same or different; provided that when X is the carbon atom or the nitrogen atom, R1 to R8 each represent one of a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, and a substituted or unsubstituted thioalkoxy group, and may be the same or different; and Y1 and Y2 each represent one of structures expressed by General Formulas (II) and (III), and may be the same or different: General Formula (II) General Formula (III).
    Type: Application
    Filed: March 17, 2010
    Publication date: February 9, 2012
    Inventors: Masato Shinoda, Satoshi Yamamoto, Toshiya Sagisaka, Takuji Kato, Takashi Okada, Daisuke Goto, Shinji Matsumoto, Masataka Mohri
  • Publication number: 20110309307
    Abstract: The present invention relates to the use of heterocyclic compounds as the charge transport material, blocker material or light-scattering material in electronic, optoelectronic or electroluminescent components.
    Type: Application
    Filed: December 14, 2009
    Publication date: December 22, 2011
    Applicant: NOVALED AG
    Inventors: Olaf Zeika, Horst Hartmann, Ulrich Heggemann, Sascha Dorok, Jan Blochwitz-Nimoth, Ansgar Werner, Michael Hofmann, Carsten Rothe
  • Publication number: 20110294662
    Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.
    Type: Application
    Filed: April 14, 2011
    Publication date: December 1, 2011
    Applicant: Bayer CropScience AG
    Inventors: Thomas SEITZ, Jürgen Benting, Ulrike Wachendorff-Neumann
  • Publication number: 20110294785
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Application
    Filed: August 21, 2009
    Publication date: December 1, 2011
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang
  • Publication number: 20110281915
    Abstract: The present invention relates to new thienodithiine derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these thienodithiine derivatives.
    Type: Application
    Filed: April 14, 2011
    Publication date: November 17, 2011
    Applicant: Bayer CropScience AG
    Inventors: Thomas SEITZ, Jürgen Benting, Ulrike Wachendorff-Neumann
  • Patent number: 8053576
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: November 8, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Publication number: 20110160357
    Abstract: Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation and/or are able to reduce the surface energy of organic materials comprise at least one compound of the formula (I) wherein the general symbols are as defined in claim 1.
    Type: Application
    Filed: March 31, 2009
    Publication date: June 30, 2011
    Applicant: BASF SE
    Inventors: Michèle Gerster, Manuel Mihalic
  • Patent number: 7951962
    Abstract: An organic semiconductor compound is represented by a general formula 1: wherein A and B each are an aromatic ring with a conjugated electron system and X and Y each are DR2, ER or G in which D denotes any of C, Si, Ge and Sn, E denotes any of N, P, As and Bi, G denotes any of O, S, Se and Te and R denotes any of H, an alkyl group and an aryl group.
    Type: Grant
    Filed: September 5, 2007
    Date of Patent: May 31, 2011
    Assignee: Seiko Epson Corporation
    Inventors: Takao Nishikawa, Satoshi Ogawa
  • Publication number: 20110124883
    Abstract: A method of preparing a sultine from a dihalogeno compound. The method comprises the steps of reacting the dihalogeno compound with a hydroxymethanesulfinate salt in a DMSO solvent so as to prepare the sultine.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 26, 2011
    Inventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley
  • Publication number: 20110114184
    Abstract: Polymers which can be used in p-type materials for organic electronic devices and photovoltaic cells. Compounds, monomers, dimers, trimers, and polymers comprising: wherein A1 and A2 each independently comprise a fused ring system comprising at least two fused rings directly covalently linked to the pyrrole rings. Good photovoltaic efficiency and lifetime can be achieved. The R group can provide solubility, environmental stability, and fine tuning of spectroscopic and/or electronic properties. Different polymer microstructures can be prepared which encourage multiple band gaps and broad and strong absorptions. The carbonyl can interact with adjacent thiophene rings to provide backbone with rigidity, induce planarity, and reduce and/or eliminate intramolecular chain twisting defects.
    Type: Application
    Filed: September 1, 2010
    Publication date: May 19, 2011
    Inventors: Christopher T. Brown, Christophe René Gaston Grenier, Chad Landis, Elena E. Sheina, Ting Xu
  • Publication number: 20100283040
    Abstract: This invention is directed to selenophene compounds, selenophene-based polymers (polyselenophene), processes for the preparation of the same and uses thereof. The polyselenophenes of this invention have high conductivity and can be used as electrodes in various devices such as in electrochromic devices, batteries, solar cells, optical amplifiers, organic light emitting diodes, and the like.
    Type: Application
    Filed: September 10, 2008
    Publication date: November 11, 2010
    Inventors: Michael Bendikov, Asit Patra, Yair-Haim Wijsboom, Mao Li, Yana Sheynin, Natalia Zamoshchik, Sanjio S. Zade
  • Patent number: 7799931
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: September 21, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Patent number: 7772409
    Abstract: A method of preparing a sultine of formula (V) from a dihalogeno compound of formula (IV) is provided. The method comprises reacting the dihalogeno compound (IV) with a hydroxymethanesulfinate salt in a DMSO solvent, wherein: R1, R2, R3 and R4 are each independently selected from hydrogen, hydroxyl, C1-20alkyl, C1-20alkoxy, amino, C1-20alkylamino, di(C1-20alkyl)amino, halogen, cyano, thiol, C1-20alkylthio, nitro, C1-20alkylcarboxy, C1-20alkylcarbonyl, C1-20alkoxycarbonyl, C1-20alkylcarbonyloxy, C1-20alkylcarbonylamino, C5-20aryl, C5-20arylalkyl, C5-20arylalkoxy, C5-20heteroaryl, C5-20heteroaryloxy, C5-20heteroarylalkoxy or C5-20heteroarylalkyl; and X is Cl, Br or I.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: August 10, 2010
    Assignee: Silverbrook Research Pty Ltd
    Inventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley, Kia Silverbrook
  • Publication number: 20100168156
    Abstract: Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.
    Type: Application
    Filed: October 25, 2006
    Publication date: July 1, 2010
    Inventors: Takashi Mizutani, Nagaaki Sato, Takahide Sasaki, Toshiyuki Takahashi
  • Publication number: 20100160411
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided, wherein each of R1, R2, R3, R4, y, n, m, p, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
    Type: Application
    Filed: October 24, 2007
    Publication date: June 24, 2010
    Applicant: Wyeth
    Inventors: Gary Paul Stack, Ivana Bianchi, Stefania Vallese, Giovanna Luoni
  • Publication number: 20090163572
    Abstract: A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is selected from H and OMe, R2 is selected from OH, OMe and OEt, and R3 is selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.
    Type: Application
    Filed: December 19, 2008
    Publication date: June 25, 2009
    Inventor: David C. Bom
  • Publication number: 20090105166
    Abstract: The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as ?-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).
    Type: Application
    Filed: August 21, 2007
    Publication date: April 23, 2009
    Inventors: Mark A. Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, David Vensel, Chiang J. Li
  • Patent number: 7514461
    Abstract: The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: April 7, 2009
    Assignee: Edison Pharmaceuticals, Inc.
    Inventors: Bing Wang, Gail Walkinshaw, Sekhar Boddupalli, Arkadij M. Elizarov, Xianming Jin, Xianfeng Li, Donald R. James, Jiangao Song, Jian Chen, Wei Zhang
  • Publication number: 20090043108
    Abstract: A method of preparing a sultine of formula (V) from a dihalogeno compound of formula (IV) is provided. The method comprises reacting the dihalogeno compound (IV) with a hydroxymethanesulfinate salt in a DMSO solvent, wherein: R1, R2, R3 and R4 are each independently selected from hydrogen, hydroxyl, C1-20alkyl, C1-20alkoxy, amino, C1-20alkylamino, di(C1-20alkyl)amino, halogen, cyano, thiol, C1-20alkylthio, nitro, C1-20alkylcarboxy, C1-20alkylcarbonyl, C1-20alkoxycarbonyl, C1-20alkylcarbonyloxy, C1-20alkylcarbonylamino, C5-20aryl, C5-20arylalkyl, C5-20arylalkoxy, C5-20heteroaryl, C5-20heteroaryloxy, C5-20heteroarylalkoxy or C5-20heteroarylalkyl; and X is Cl, Br or I.
    Type: Application
    Filed: August 1, 2007
    Publication date: February 12, 2009
    Inventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley, Kia Silverbrook
  • Patent number: 7405308
    Abstract: Triarylsulfonium salts of formula I or II are useful as initiators for cationic photopolymerizations: wherein Ar1 and Ar2 are independently polycyclic aryl, substituted aryl, heteroaryl, substituted heteroaryl, or aryl or heteroaryl, pendant from a polymer chain; and MtXn? is a complex anion selected from PF6?, SbF6?, AsF6?, GaF6?, BF4?, (C6F5)4B? and CF3SO2)3C?.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: July 29, 2008
    Assignee: Rensselaer Polytechnic Institue
    Inventor: James V. Crivello
  • Publication number: 20080105865
    Abstract: An object is to provide a pyrene based compound that is good in both properties of light emission and mobility when the compound is used as a light emitting transistor element; and a light emitting transistor element wherein this specific pyrene based compound is used. A pyrene based compound represented by the following chemical formula (1) is used as a main component of a light emitting layer in a light emitting transistor element: (wherein R1 represents a group selected from a heteroaryl group which may have a substituent, an aryl group which may have a substituent except a phenyl group which does not have any substituent, an alkyl group which may have a substituent and has a main chain having 1 to 20 carbon atoms, an alkenyl group which may have a substituent, an alkynyl group which may have a substituent, a silyl group which may have a substituent, and a halogen atom.
    Type: Application
    Filed: November 25, 2005
    Publication date: May 8, 2008
    Inventors: Takahito Oyamada, Hiroyuki Uchiuzou, Chihaya Adachi, Seiji Akiyama, Takayoshi Takahashi
  • Patent number: 7368567
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, n, p, Ar, X, R1, R2, R3, R4, R5 and R6 are as defined herein. Also provided are compositions comprising, methods of preparing, and methods of using the subject compounds.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: May 6, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Shu-Hai Zhao
  • Patent number: 7301705
    Abstract: The alicyclic compound of the present invention has a five- or more membered ring structure having an epithioethylene linkage and/or an epidithioethylene linkage, and has tow or more sulfur atoms in its molecule. Optical materials produced by curing the alicyclic compound or a composition containing the alicyclic compound by polymerization show high refractive index.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: November 27, 2007
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Yuichi Yoshimura, Motoharu Takeuchi, Teruo Kamura
  • Patent number: 7291742
    Abstract: A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid of formula (I), or a salt thereof, and the intermediates thereof, useful as an intermediate in the preparation of zonisamide.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: November 6, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Graziano Castaldi, Plietro Allegrini, Vittorio Lucchini, Alberto Bologna
  • Patent number: 6998407
    Abstract: Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The compounds are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: February 14, 2006
    Assignees: Telik, Inc., Sanwa Kagaku Kenkyusho Co. Ltd.
    Inventors: Edgardo Laborde, Louise Robinson, Fanying Meng, Brian T. Peterson, Hugo O. Villar, Steven E. Anuskiewicz, Yoshiro Ishiwata, Shoji Yokochi, Yukiharu Matsumoto, Takuji Kakigami, Hideaki Inagaki, Takahito Jomori, Kouji Matsushima
  • Patent number: 6764777
    Abstract: The compound represented by the general formula (I): wherein each of R1 to R12 and RA1 to RA6 represents a hydrogen atom or a substituent group, and adjacent groups of R1 to R11 and RA1 to RA6 may be bonded to each other to form a ring. The light-emitting device of the present invention comprises a pair of electrodes and one or more organic layers disposed therebetween, at least one of the organic layers comprising the above compound.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: July 20, 2004
    Assignee: Fuji Photo Film Co., Ltd.
    Inventor: Toshihiro Ise
  • Patent number: 6730697
    Abstract: Dihydrothiaphenanthrenecarbonylguanidine compound of formula I These compounds are potentially suitable as antiarrythmic medicaments with a cardioprotective component for prophylaxis of an infarction and treatment of infarction, and for treatment of angina pectoris. They may also inhibit in a preventive manner the pathophysiological processes involved in the development of ischemia-induced damage, especially in the initiation of ischemia-induced cardiac arrhythmias.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: May 4, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Heinz-Werner Kleemann, Peter Below
  • Patent number: 6727258
    Abstract: The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection against hypoxia and ischemia induced injury and treatment of adenosine-sensitive cardiac arrhythmias.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: April 27, 2004
    Assignee: King Pharmaceutical Research & Development, Inc.
    Inventor: Pier Giovanni Baraldi
  • Patent number: 6696540
    Abstract: An episulfide compound useful as a starting material for optical materials that have a high refractive index and a high Abbe's number is provided. A method for producing the same and an optical product made with the same are also provided. The episulfide compound may be represented by the general formula (1): wherein EP represents and n is an integer of from 0 to 2. A method for producing the episulfide compound represented by the general formula (1) may involve reacting a mercapto group-containing episulfide compound with 2,4,6-trimethylene-1,3,5-trithiane.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: February 24, 2004
    Assignee: Hoya Corporation
    Inventors: Tsuyoshi Okubo, Ken Takamatsu