Silicon Containing Patents (Class 549/214)
  • Patent number: 10717804
    Abstract: The present invention provides a silicon-containing compound shown by the following formula (1): wherein R1, R2, R3, R4, R5, and R6 each independently represent a linear, branched, or cyclic alkyl group having 1 to 6 carbon atoms, a phenyl group, a 3,3,3-trifluoropropyl group, or a group shown by —(OSiR7R8)n—OSiR9R10R11; R7, R8, R9, R10, and R11 have the same meanings as R1 to R6; X represents a linear or branched alkylene group having 3 to 7 carbon atoms optionally having an ether group; and “n” is an integer in the range of 0 to 100. This provides a stretchable film that has excellent stretchability and strength, with the film surface having excellent repellency, and a method for forming the same; as well as a urethane resin used for the stretchable film; and a silicon-containing compound to be a material of the urethane resin.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: July 21, 2020
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Shiori Nonaka, Yuji Harada, Ryo Mitsui, Osamu Watanabe
  • Patent number: 10696779
    Abstract: The present invention provides a silicon-containing compound shown by the following formula (1): wherein R1, R2, R3, R4, R5, and R6 each independently represent a linear, branched, or cyclic alkyl group having 1 to 6 carbon atoms, a phenyl group, a 3,3,3-trifluoropropyl group, or a group shown by —(OSiR7R8)n—OSiR9R10R11; R7, R8, R9, R10, and R11 have the same meanings as R1 to R6; “n” is an integer in the range of 0 to 100; and “A” represents a linear or branched alkylene group having 1 to 6 carbon atoms. This provides a stretchable film that has excellent stretchability and strength, with the film surface having excellent repellency, and a method for forming the same; as well as a urethane resin used for the stretchable film; and a silicon-containing compound to be a material of the urethane resin.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: June 30, 2020
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Yuji Harada, Shiori Nonaka, Ryo Mitsui, Osamu Watanabe
  • Patent number: 10669294
    Abstract: A new class of cyclotrisiloxanes having alkyl ether substituents on one, two, or three of the ring silicon atoms and a method for their preparation are provided. These compounds undergo living anionic ring-opening polymerization to generate unique polymer structures. A new class of hydridosilylethylcyclotrisiloxanes is also described.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 2, 2020
    Assignee: Gelest Technologies, Inc.
    Inventors: Jonathan D. Goff, Barry C. Arkles
  • Patent number: 10611773
    Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: April 7, 2020
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Francis G. Fang, Dae-Shik Kim, Hyeong-Wook Choi, Charles E. Chase, Jaemoon Lee
  • Patent number: 10538539
    Abstract: A method for preparing a 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivative by a simple process with high yields, and an intermediate useful for the method.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: January 21, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik Shin, Kee Young Lee, Changyoung Oh
  • Patent number: 10322990
    Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: June 18, 2019
    Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
  • Patent number: 10221189
    Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: March 5, 2019
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Francis G. Fang, Dae-Shik Kim, Hyeong-Wook Choi, Charles E. Chase, Jaemoon Lee
  • Patent number: 9822244
    Abstract: The invention relates to an off-road tire comprising a composition based on at least one filler, a crosslinking system, from 50 to 80 parts by weight, per hundred parts by weight of elastomer (phr), of at least one isoprene elastomer and from 20 to 50 phr of at least one polybutadiene having a high vinyl content, the total content of isoprene elastomer and of polybutadiene having a high vinyl content being within a range varying from 85 to 100 phr.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: November 21, 2017
    Assignees: COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN, MICHELIN RECHERCHE ET TECHNIQUE S.A.
    Inventor: Aurelie Joseph
  • Patent number: 9382272
    Abstract: There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: July 5, 2016
    Assignee: Apotex Pharmachem Inc.
    Inventors: Kiran Kumar Kothakonda, Fan Wang, Bhaskar Reddy Guntoori, Minh T. N. Nguyen, Alfredo Paul Ceccarelli, Yajun Zhao, Uma Kotipalli, Sammy Chris Duncan, Kaarina K. Milnes, Kevin Wade Kells, Laura Kaye Montemayor
  • Patent number: 9375484
    Abstract: The invention provides silicate prodrugs comprising a therapeutic agent linked to one or more groups of formula (I): —Si(OR)3 (I); wherein each R independently has any of the values defined herein, as well as nanoparticles comprising such compounds.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: June 28, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Thomas R. Hoye, Adam Wohl, Christopher W. Macosko, Jayanth Panyam
  • Patent number: 9260401
    Abstract: The present invention relates to a novel method for preparing cabazitaxel from 10-deacetylbaccatin III, and a novel intermediate therefor, and more specifically, to: a method which allows cabazitaxel to be more easily prepared in a high yield and in a high purity within a short time compared with a conventional method by preparing cabazitaxel via a novel intermediate using 10-deacetylbaccatin III as a starting material, and thus is suitable for industrial mass production; and a novel intermediate therefor.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: February 16, 2016
    Assignee: SAMYANG BIOPHARMACEUTICALS CORPORATION
    Inventors: Na Young Lee, Seong Ho Kim, Young Min Kim, Jin Suk Cho, Moon Suk Kim
  • Patent number: 9181212
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analog compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: November 10, 2015
    Assignee: Lung Biotechnology PBC
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Patent number: 9161922
    Abstract: A therapeutic agent for selectively inhibiting amine oxidases associated diseases and conditions in humans includes at least one compound selected from the group consisting of propargylamines, polypropargylamines, homopropargylamines, 4-substituted-2-butynylamines, 2- and 3-halloallylamines, pyrroline derivatives, cycloalkenyl branched primary amines, propargyl diamines, homopropargyl amines and diamines, allenyl amines and diamines, chloroallyl diamines, lysyne analogs, ?-haloamines, RF-substituted amines, RCi-substituted amines, and R3Si substituted amines.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: October 20, 2015
    Assignee: Case Western Reserve University
    Inventor: Lawrence M. Sayre
  • Patent number: 9155804
    Abstract: A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R?1, R?2, R?3, R7? and R8? are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R?4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R?5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R?7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 13, 2015
    Assignee: General Electric Company
    Inventors: Brian James Grimmond, Michael James Rishel, Jeannette Christine Roberts
  • Patent number: 9145430
    Abstract: A separating agent for chromatography is provided that is useful for the separation of specific compounds, e.g., for the optical resolution of amino acids. This separating agent for chromatography provides a higher productivity and contains a crown ether-like cyclic structure and optically active binaphthyl. This separating agent for chromatography containing a crown ether-like cyclic structure and optically active binaphthyl is provided by introducing a substitution group for binding to a carrier into a specific commercially available 1,1?-binaphthyl derivative that has substituents at the 2, 2?, 3, and 3? positions, then introducing a crown ether-like cyclic structure, and subsequently chemically bonding the binaphthyl derivative to the carrier through the substitution group for binding to the carrier.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: September 29, 2015
    Assignee: DAICEL CORPORATION
    Inventors: Keiji Nishihara, Junichi Ishii
  • Patent number: 9136486
    Abstract: The purpose of the invention is to provide: a composition for an organic semiconductor insulating film, which is capable of forming an insulating film that exhibits excellent hydrophobicity and smoothness of the surface, while having excellent electrical stability; and an organic semiconductor insulating film obtained by using the composition for an organic semiconductor insulating film. The present composition contains a polysiloxane and an organic polymer compound. The polysiloxane is a polyhedral silsesquioxane having an oxetanyl group and/or an oxetanyl group containing silicon compound represented by the following formula (1). In the formula (1), each of R1-R3 independently represents a monovalent organic group (provided that at least one of R1-R3 is a monovalent organic group having an oxetanyl group); and each of v, w, x and y independently represents 0 or a positive number (provided that w and at least one of v, x and y are positive numbers).
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: September 15, 2015
    Assignee: TOAGOSEI CO., LTD.
    Inventors: Hiroshi Suzuki, Akinori Kitamura, Takashi Hamada
  • Patent number: 9123647
    Abstract: Provided are a curable composition, a light emitting diode, a liquid crystal display, and a lighting apparatus. The curable composition may have excellent processibility and workability, and excellent crack resistance, hardness, thermal resistance, transparency and adhesiveness after curing. The composition has neither whitening after being applied nor surface stickiness. The composition may be useful as an adhesive or encapsulating material of an optical semiconductor device such as an LED, a CCD or a photocoupler.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: September 1, 2015
    Assignee: LG CHEM, LTD.
    Inventors: Min Kyoun Kim, Min Jin Ko, Myungsun Moon, Jae Ho Jung, Bum Gyu Choi, Dae Ho Kang
  • Publication number: 20150137111
    Abstract: A compound for an organic optoelectronic device, an organic light-emitting device including the same and a display device including the organic light-emitting device are provided, and the compound for an organic optoelectronic device represented by a combination of the following Chemical Formulae 1 and 2 is provided and thus an organic light-emitting device has improved life-span characteristics due to excellent electrochemical and thermal stability, and high luminous efficiency at a low driving voltage.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 21, 2015
    Inventors: Dong-Wan RYU, Nam-Heon LEE, Han-Ill LEE, Sung-Hyun JUNG, Young-Kyoung JO, Mi-Young CHAE, Dal-Ho HUH, Jin-Seok HONG
  • Patent number: 9028880
    Abstract: The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: May 12, 2015
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jianjun Cheng, Li Tang
  • Publication number: 20150122734
    Abstract: A method of separating one or more valuable metal cations from an ionic solution by (a) contacting the ionic solution with an activated photoisomerizable host molecule containing a photoisomerizable moiety and a host moiety, where the photoisomerizable moiety has first and second states, and where the host moiety has a greater affinity for a metal cation when the photoisomerizable moiety is in the first state (active binding state) than when the photoisomerizable moiety is in the second state (release state), so that an ion-host molecule association is formed, and (b) separating the ion-host molecule association from the ionic solution. Also disclosed are photoisomerizable host molecules, a method of recovering valuable metals from a waste stream using the photoisomerizable host molecules, and an apparatus comprising a photoisomerizable host molecule attached to a support.
    Type: Application
    Filed: June 7, 2013
    Publication date: May 7, 2015
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Richard E. Riman, Brook Porter
  • Patent number: 9018400
    Abstract: A new functionalized polyhedral octavinylsilsesquioxanes having the general formula 1, in which R1 denotes: (1) any aryl group other than a non-substituted phenyl or a phenyl substituted in position four with a halogen or the groups-trimethylsilylethynyl, 4,4,5,5-tetramethyl-1,3-dioxaborolane-2-yl, 3,4-dimethoxyphenyl, 3?,5?-bis(methoxycarbonyl)phenyl or benzo[d][1,3]-dioxol-5-yl; (2) any heteroaryl group; or (3) groups including coupled aromatic rings. Additionally, a method to obtain new and known functionalized polyhedral octavinylsilsesquioxanes having the general formula 1, by the silylating coupling of octavinylsilsesquioxane with olefins in the presence of a ruthenium complex catalyst.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: April 28, 2015
    Assignee: Adam Mickiewicz University
    Inventors: Bogdan Marciniec, Cezary Pietraszuk, Mariusz Majchrzak, Patrycja Zak
  • Publication number: 20150108440
    Abstract: A condensed cyclic compound and an organic light-emitting device, the compound being represented by Formula 1:
    Type: Application
    Filed: June 10, 2014
    Publication date: April 23, 2015
    Inventors: Hye-Jin JUNG, Jin-O LIM, Sang-Hyun HAN
  • Patent number: 9000193
    Abstract: The present invention discloses a process for the preparation of 4-acetoxy-2?-benzoyloxy-5?,20-epoxy-1-hydroxy-7?,10?-dimethoxy-9-oxotax-11-en-13?-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate Cabazitaxel (I).
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: April 7, 2015
    Assignee: Fresenius Kabi Oncology Limited
    Inventors: Saswata Lahiri, Nitin Gupta, Abul Azim, Nilendu Panda, Bhuwan Bhaskar Mishra, Sunil Sanghani
  • Patent number: 9000167
    Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: April 7, 2015
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Alexey Fedorov, Anton Toutov, Kerry Betz
  • Publication number: 20150080337
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-[(trisubstitutedsilylphenyl)methylene]carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Application
    Filed: April 18, 2013
    Publication date: March 19, 2015
    Inventors: Pierre Cristau, Philippe Desbordes, Mazen Es-Sayed, Marie-Claire Grosjean-Cournoyer, Helene Lachaise, Philippe Rinolfi, Jan-Peter Schmidt, Tomoki Tsuchyia, Jean-Pierre Vors
  • Publication number: 20150076462
    Abstract: An organic electroluminescent element comprising a substrate, a pair of electrodes including an anode and a cathode, disposed on the substrate, and at least one organic layer which is arranged between the electrodes and which includes a light emitting layer, wherein the organic layer contains a compound represented by general formula (1) in at least one layer. The organic electroluminescent element has a high luminous efficiency, excellent blue color purity, and little chromaticity change due to drive deterioration. (In the formula, the two Xs either both represent an O atom or both represent an S atom, and R1-R10 each independently represents a hydrogen atom or a substituent group).
    Type: Application
    Filed: October 5, 2012
    Publication date: March 19, 2015
    Applicant: UDC IRELAND LIMITED
    Inventors: Tetsu Kitamura, Koji Takaku, Wataru Sotoyama, Yasunori Yonekuta, Toru Watanabe, Masaru Kinoshita
  • Publication number: 20150069344
    Abstract: A condensed cyclic compound and an organic light-emitting device including the same, the compound being represented by Formula 1, below: Ar1-(L11)b1-(L1)a1-(L12)b2-Ar2.
    Type: Application
    Filed: May 15, 2014
    Publication date: March 12, 2015
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Jong-Woo KIM, Seok-Hwan HWANG, Young-Kook KIM, Hye-Jin JUNG, Jun-Ha PARK, Eun-Young LEE, Jin-O LIM, Sang-Hyun HAN, Kwang-Hyun KIM, Eun-Jae JEONG, Soo-Yon KIM
  • Patent number: 8975420
    Abstract: A 5-membered cyclic carbonate polysiloxane compound is represented by the below-described formula (1), and is produced by a process that reacts an epoxy-modified polysiloxane compound with carbon dioxide. wherein A means in which R1 means an alkylene group which has from 1 to 12 carbon atoms and may be linked via an element of O, S or N and/or —(C2H4O)b—, R2 means a direct bond or an alkylene group having from 2 to 20 carbon atoms, R2 may be linked to an alicyclic group or aromatic group, b stands for a number of from 1 to 300, and a stands for a number of from 1 to 300.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: March 10, 2015
    Assignees: Dainichiseika Color & Chemicals Mfg. Co., Ltd., Ukima Chemicals & Color Mfg. Co., Ltd.
    Inventors: Kazuyuki Hanada, Kazuya Kimura, Kenichi Takahashi, Osamu Kawakami, Manabu Uruno
  • Publication number: 20150057454
    Abstract: The present invention discloses a process for the preparation of 4-acetoxy-2?-benzoyloxy-5?,20-epoxy-1-hydroxy-7?,10?-dimethoxy-9-oxotax-11-en-13?-yl(2 R,35)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate Cabazitaxel (I).
    Type: Application
    Filed: November 5, 2014
    Publication date: February 26, 2015
    Inventors: Saswata Lahiri, Nitin Gupta, Abul Azim, Nilendu Panda, Bhuwan Bhaskar Mishra, Sunil Sanghani
  • Patent number: 8962866
    Abstract: Provided by the present invention is a surface-modified silica powder, characterized in that the said powder is obtained by surface treatment of a silica powder with one or two or more of a compound (A) and with an aminosilane (B), wherein the fixing rate of the compound (A) and the aminosilane (B) is a total of 50% or more, the hydrophobic rate is 80% or more, and the triboelectrostatic charge amount is 200 ?C/g or less in its absolute value. The surface-modified silica powder of the present invention can stabilize many properties including fluidity and electrostatic properties while can significantly reduce problems such as fogging and decrease in image quality without significantly deteriorating characteristics of a developing agent and so forth when this is used as an external additive.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: February 24, 2015
    Assignees: Nippon Aerosil Co., Ltd., Hodogaya Chemical Co., Ltd.
    Inventors: Yuki Amano, Naohiro Naito, Hisao Okada, Masaki Okubo, Yoshikazu Aoki, Hideyuki Otsuka
  • Publication number: 20150031898
    Abstract: A convergent synthesis of the prostaglandin F2? analogues, travoprost and bimatoprost, was developed employing Julia-Lythgoe olefination of the structurally advanced phenylsulfone with an enantiomerically pure aldehyde ?-chain synthon. The novel convergent strategy allows the synthesis of a whole series of prostaglandin analogues of high purity from a common and structurally advanced prostaglandin intermediate.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 29, 2015
    Applicant: INSTYTUT FARMACEUTYCZNY
    Inventors: Iwona Dams, Andrzej Kutner, Michal Chodynski, Malgorzata Krupa, Anita Pietraszek, Marta Zezula, Piotr Cmoch, Monika Kosinska
  • Publication number: 20150014666
    Abstract: An aromatic amine derivative is represented by a formula (1) below. In the formula (1), R2, R3, R4, R5, R7, R8, R9 and R10 each independently represent a hydrogen atom and a substituent. In the formula (1), R1 and R6 are represented by a formula (2) below, and L1 to L2 are each independently a single bond, a divalent residue of an aryl group, and the like. L3 is a divalent residue of an aryl group and the like. In the formula (2); Ar1 is a monovalent substituent having a partial structure represented by the following formula (3); X represents an oxygen atom or a sulfur atom; and A and B represent a six-membered ring. In the formula (2), Ar2 is an aryl group, a monovalent substituent having a partial structure represented by the formula (3), and the like.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 15, 2015
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Yumiko Mizuki, Hirokatsu Ito
  • Patent number: 8927237
    Abstract: An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R1 represents an acyl group). Then, an acetylene organic metal compound represented by formula (III) (wherein R2 represents a hydrogen atom or a tri-substituted silyl group, and M represents an alkali metal atom, aluminum, or a magnesium monohalide) and a coordinating additive are caused to act on the acyloxypyranone compound represented by formula (II), to thereby produce an alkyne compound represented by formula (IV). The alkyne compound represented by formula (IV) is hydrolyzed with acid, to thereby produce a dihydrofuran compound represented by formula (V).
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: January 6, 2015
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Yoshikazu Ootsuka, Tomohiro Akeboshi, Akiko Yamazaki, Yusuke Iriyama
  • Patent number: 8927749
    Abstract: A compound according to a formula I and devices incorporating the same are described. The compound according to the formula I can have the structure: wherein X is Si or Ge; R1 and R2 represent mono, di, tri, tetra, or penta substitutions or no substitution; R3, R4 represent mono, di, tri, or tetra substitutions or no substitution; R1 and R2 are optionally joined to form a ring, which may be further substituted; L is a single bond or comprises an aryl or heteroaryl group having from 5-20 carbon atoms, which is optionally further substituted; and A is an aromatic group. A contains a group selected from the group consisting of indole, carbazole, benzofuran, dibenzofuran, benzothiophene, dibenzothiophene, benzoselenophene, dibenzoselenophene, triphenylene, azacarbazole, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, azatriphenylene, and combinations thereof, which are optionally further substituted. The device can include the compound according to Formula I in an organic layer.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: January 6, 2015
    Assignee: Universal Display Corporation
    Inventors: Pierre-Luc T. Boudreault, Chuanjun Xia
  • Publication number: 20140361266
    Abstract: A condensed cyclic compound of Formula 1 is provided. An organic light-emitting device includes the same.
    Type: Application
    Filed: February 14, 2014
    Publication date: December 11, 2014
    Applicant: Samsung Display Co., Ltd.
    Inventors: Hye-Jin Jung, Seok-Hwan Hwang, Young-Kook Kim, Jun-Ha Park, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim
  • Publication number: 20140353646
    Abstract: An aromatic amine derivative is represented by a formula (1-1) below. In the formula (1-1), R2 to R5 and R7 to R10 are each independently a hydrogen atom or a substituent. In the formula (1-1), R1 and R6 are represented by a formula (2-1) below, and L1 to L3 are each independently a single bond, a divalent residue of an aryl group, and the like. In the formula (2-1); Ar1 is a monovalent substituent having a partial structure represented by a formula (3-1) below; X is an oxygen atom or a sulfur atom; and A and B represent a six-membered ring. In the formula (2-1), Ar2 is an aryl group or a heterocyclic group. The monovalent substituent having the partial structure represented by the formula (3-1) includes at least one of a fluorine atom and the like.
    Type: Application
    Filed: September 21, 2012
    Publication date: December 4, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Yumiko Mizuki, Hirokatsu Ito
  • Patent number: 8901319
    Abstract: A process for the synthesis and purification of F-series prostaglandin compounds and synthetic intermediates used to prepare them. The synthetic intermediates are solid and may be purified by precipitation and therefore may form the representative F-series prostaglandin compounds such as latanoprost, bimatoprost, fluprostenol, cloprostenol, and substituted analogs therefrom in highly pure forms.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: December 2, 2014
    Assignee: Cayman Chemical Company, Incorporated
    Inventors: Gilles Chambournier, Andriy Kornilov, Hussein M. Mahmoud, Ivan Vesely, Stephen D. Barrett
  • Publication number: 20140346482
    Abstract: An aromatic amine derivative is represented by the following formula (1). In the formula (1), R1 to R10 each independently represent a hydrogen atom and a substituent. In the formula (1); R1 is represented by the following formula (2); any one of R2 to R5 and R7 to R10 is represented by the following formula (2); and L1 to L3 each independently represent a single bond, a divalent residue of an aryl group, or the like. In the formula (2); Ar1 is a monovalent substituent having a partial structure represented by the following formula (3); X represents an oxygen atom or a sulfur atom; and A and B represent a six-membered ring. In the formula (2), Ar2 is an aryl group, a monovalent substituent having a partial structure represented by the formula (3), and the like.
    Type: Application
    Filed: September 14, 2012
    Publication date: November 27, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Yumiko Mizuki, Hirokatsu Ito
  • Publication number: 20140342384
    Abstract: A compound represented by the formula (I) (R1 represents a substituent on the benzene ring; R2 represents a monovalent substituent; R3 and R4 represent hydrogen atom, or an alkyl group; R5 and R6 represent an alkyl group, or an aryl group; R7 and R8 represent hydrogen atom, or an alkyl group; R9 and R10 represent hydrogen atom, or a monovalent substituent; and X represents silicon atom, germanium atom, or tin atom), or a salt thereof.
    Type: Application
    Filed: February 17, 2012
    Publication date: November 20, 2014
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa, Yu Kushida
  • Patent number: 8884031
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: November 11, 2014
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Charles E. Chase, Francis G. Fang
  • Publication number: 20140326985
    Abstract: An aromatic amine derivative is represented by a formula (1) below. In the formula (1), R2 to R5, R7 to R9 and R10 are each independently a hydrogen atom or a substituent. In the formula (1), R1 and R6 are represented by a formula (2) below, and L1 to L3 are each independently a single bond and the like. In the formula (2), Ar1 is a monovalent residue derived from the ring structure represented by a formula (4) below, X is an oxygen atom or a sulfur atom, and at least one of R11 to R18 is an alkyl group. In the formula (1), Ar2 is an aryl group or a monovalent residue derived from the ring structure represented by the formula (4).
    Type: Application
    Filed: November 22, 2012
    Publication date: November 6, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Yumiko MIZUKI, Hirokatsu ITO
  • Publication number: 20140291652
    Abstract: An organic electroluminescent element using a compound represented by the following general formula (I) emits dark blue light and has small changes in the chromaticity and in the driving voltage even after driving for a long period of time: wherein R1 to R6; Q1 and Q2; X1, X2, X3 and X4 are as defined herein.
    Type: Application
    Filed: August 6, 2012
    Publication date: October 2, 2014
    Applicant: UDC IRELAND LIMITED
    Inventors: Saki Takada, Koji Takaku, Tetsu Kitamura, Toshihiro Ise, Wataru Sotoyama
  • Publication number: 20140275537
    Abstract: Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one (13, RX-3117) and its intermediates are described.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Applicant: Rexahn Pharmaceuticals, Inc.
    Inventors: Haifeng YIN, Deog Joong KIM, Eliezer FALB, Leigh Andre PEARCEY, Jonathan CUMMINS, Petra DIETERICH, Jean-Francois CARNIAUX
  • Publication number: 20140275573
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 18, 2014
    Applicant: LUNG BIOTECHNOLOGY INC.
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Publication number: 20140275572
    Abstract: The present invention relates to the synthesis of ent-progesterone and intermediates thereof.
    Type: Application
    Filed: March 15, 2014
    Publication date: September 18, 2014
    Inventors: John W. Cran, Yinglin Han, Faliang Zhang
  • Publication number: 20140261647
    Abstract: A novel compound represented by general formula (1), a support supporting this novel compound, and a photoelectric transduction element using this support. (In the formula, Y is an optionally substituted hydrocarbon group having 1-20 carbon atoms having —CO—NR4- or —SO2—NR4- in the group; Z is a group of a conjugated system; R1, R2, and R3 represent optionally substituted hydrocarbon groups or optionally substituted hydrocarbon-oxy groups; at least one of R1, R2, and R3 is an optionally substituted hydrocarbon-oxy group; R4 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1-20 carbon atoms; R4 and Z may join together to form a ring. However, Y excludes groups represented by partial structural formulas (Y-11) and (Y-12).
    Type: Application
    Filed: August 21, 2012
    Publication date: September 18, 2014
    Applicant: ADEKA CORPORATION
    Inventors: Yohei Aoyama, Kazuyuki Noda, Hiroyuki Osada
  • Patent number: 8835656
    Abstract: The invention provides a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3? terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker contains a compound represented by the formula wherein each symbol is as defined in the specification.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: September 16, 2014
    Assignees: Nitto Denko Corporation, National University Corporation Nagoya University
    Inventors: Masaki Tsukamoto, Noritaka Suzuki, Yoshihiro Hayakawa, Eri Maeta, Kenjiro Mori, Kenjiro Minomi
  • Publication number: 20140252318
    Abstract: A compound according to a formula I and devices incorporating the same are described. The compound according to the formula I can have the structure: wherein X is Si or Ge; R1 and R2 represent mono, di, tri, tetra, or penta substitutions or no substitution; R3, R4 represent mono, di, tri, or tetra substitutions or no substitution; R1 and R2 are optionally joined to form a ring, which may be further substituted; L is a single bond or comprises an aryl or heteroaryl group having from 5-20 carbon atoms, which is optionally further substituted; and A is an aromatic group. A contains a group selected from the group consisting of indole, carbazole, benzofuran, dibenzofuran, benzothiophene, dibenzothiophene, benzoselenophene, dibenzoselenophene, triphenylene, azacarbazole, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, azatriphenylene, and combinations thereof, which are optionally further substituted. The device can include the compound according to Formula I in an organic layer.
    Type: Application
    Filed: March 7, 2013
    Publication date: September 11, 2014
    Applicant: Universal Display Corporation
    Inventors: Pierre-Luc T. Boudreault, Chuanjun Xia
  • Patent number: 8828252
    Abstract: A silsesquioxane resin is applied on top of the patterned photo-resist and cured to produce a cured silsesquioxane resin on top of the pattern surface. Subsequently, an aqueous base stripper or a reactive ion etch recipe containing CF4 is used to “etch back” the silicon resin to the top of the photoresist material, exposing the entire top surface of the photoresist. Then, a second reactive ion etch recipe containing O2 to etch away the photoresist. The result is a silicon resin film with via holes with the size and shape of the post that were patterned into the photoresist. Optionally, the new pattern can be transferred into the underlying layer(s).
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: September 9, 2014
    Assignee: Dow Corning Corporation
    Inventors: Michael L. Bradford, Eric Scott Moyer, Kasumi Takeuchi, Sheng Wang, Craig Rollin Yeakle
  • Publication number: 20140213550
    Abstract: The invention provides silicate prodrugs comprising a therapeutic agent linked to one or more groups of formula (I): —Si(OR)3 (I); wherein each R independently has any of the values defined herein, as well as nanoparticles comprising such compounds.
    Type: Application
    Filed: May 31, 2012
    Publication date: July 31, 2014
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Thomas R. Hoye, Adam Wohl, Christopher W. Macosko, Jaynath Panyam