Oxygen Containing Hetero Ring (e.g., Dioxirane, Etc.) Patents (Class 549/200)
  • Patent number: 10329269
    Abstract: The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: June 25, 2019
    Assignees: Leukogene Therapeutics Incorporated, MUSC Foundation for Research Development
    Inventors: Nathan G. Dolloff, Reeder M. Robinson, Allen B. Reitz, Haiyan Bian
  • Patent number: 9617237
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: April 11, 2017
    Assignee: Zafgen, Inc.
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Patent number: 9562002
    Abstract: Provided are STAT3 inhibitors and methods of treating inflammation or a hyperproliferative disease such as, e.g., cancer. In some aspects, compounds may be used to treat breast cancer, a head/neck cancer, a lung cancer, a prostate cancer, or pancreatic cancer.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: February 7, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jia Zhou, Haijun Chen, Qiang Shen
  • Patent number: 9545375
    Abstract: The invention relates to a method which comprises emitting ultrasound into a liquid mixture containing first and second reagents in separate phases initially separated by a liquid precursor-gas barrier, the ultrasound having a high enough energy level to vaporize the precursor gas, such as to contact the reagents and thus to activate a chemical reaction therebetween.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: January 17, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPERIEURE DE PHYSIQUE ET CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Olivier Couture, Mickael Tanter, Patrick Tabeling, Janine Cossy, Mathias Fink
  • Patent number: 9458414
    Abstract: A cleaning or personal care composition containing at least one of 1,4-pentanediol and a ketal alcohol of formula (1) wherein R2 is hydrogen or C1-3 alkyl, each R3, R4, and R5 is independently hydrogen or C1-6 alkyl, R6 and R7 are each independently hydrogen or C1-6 alkyl, a=0-3, and b=0-1. R2 is hydrogen or C1-3 alkyl, each R3, R4, and R5 is independently hydrogen or C1-6 alkyl, each R6 and R7 is independently hydrogen, C1-6 alkyl optionally substituted with at least one hydroxyl groups, a=1-6, and b=0-2.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: October 4, 2016
    Assignee: GFBIOCHEMICALS LIMITED
    Inventors: Lee R. Rieth, Satyanarayana Majeti, Erich J. Molitor
  • Patent number: 9346846
    Abstract: The present invention is directed to novel anti-cancer compounds and methods of treating and/or inhibiting cancer in patients, including metastatic cancer, recurrent cancer and drug resistant cancers, including multiple drug resistant cancers. Compounds according to the present invention provide anti-cancer activity, at least in part, by virtue of their nucleotide intercalating activity through the use of analogs of (?)lomaiviticin A, a potent anticancer agent which exhibits cytotoxicity through its principal mechanism of cleavage and to a lesser extent, its intercalation of cellular polynucleotides, especially DNA. In additional embodiments, compounds according to the present invention are also conjugated and/or linked to other bioactive agents, especially agents which selectively target cancer cells (cancer cell targeting moiety or CCTM) to target and increase the delivery of the anticancer agent to the cancer cell.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: May 24, 2016
    Assignee: YALE UNIVERSITY
    Inventors: Seth Herzon, Christina Woo, Peter M. Glazer
  • Patent number: 9345997
    Abstract: A polymer includes at least one pendant dioxirane moiety represented by Formula III or IV: In Formulas III and IV, R1 is absent or is alkylene, perhaloalkylene, cycloalkylene, arylene, heteroarylene, heterocyclylene, amino, carbonyl, carboxyl, alkylcarboxy, carboxyalkyl or alkylcarboxyalkyl; R2 is an electron withdrawing group; R8 is —N+R4R5 or alkylene; R9 is —N+R4R5 or alkylene; each R4 is independently H, alkyl, or cycloalkyl; and each R5 is independently H, alkyl, or cycloalkyl.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: May 24, 2016
    Assignee: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventors: Angele Sjong, Kraig K. Anderson
  • Patent number: 9103791
    Abstract: Disclosed are fluorescent indicators and methods for detecting the activity of an ion channel or transporter in a cell. The indicators and methods may be used to measure influx or efflux of thallium through an ion channel or a transporter.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: August 11, 2015
    Assignee: Vanderbilt University
    Inventor: Charles David Weaver
  • Patent number: 9062205
    Abstract: Alkyl amine dyes, oligonucleotide probes prepared from the alkyl amine dyes, phosphoramidites and solid supports prepared from the alkyl amine dyes, and methods of labeling biological agents using the alkyl amine dyes.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: June 23, 2015
    Assignee: Blood Cell Storage, Inc.
    Inventors: Michael W. Reed, Robert O. Dempcy
  • Patent number: 8975420
    Abstract: A 5-membered cyclic carbonate polysiloxane compound is represented by the below-described formula (1), and is produced by a process that reacts an epoxy-modified polysiloxane compound with carbon dioxide. wherein A means in which R1 means an alkylene group which has from 1 to 12 carbon atoms and may be linked via an element of O, S or N and/or —(C2H4O)b—, R2 means a direct bond or an alkylene group having from 2 to 20 carbon atoms, R2 may be linked to an alicyclic group or aromatic group, b stands for a number of from 1 to 300, and a stands for a number of from 1 to 300.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: March 10, 2015
    Assignees: Dainichiseika Color & Chemicals Mfg. Co., Ltd., Ukima Chemicals & Color Mfg. Co., Ltd.
    Inventors: Kazuyuki Hanada, Kazuya Kimura, Kenichi Takahashi, Osamu Kawakami, Manabu Uruno
  • Patent number: 8916513
    Abstract: A dioxirane-containing compound has a first substituent that is an alkyl, polyalkoxy, aryl, heteroaryl, or heterocyclyl group, and a second substituent that is an electron withdrawing group, and where the first and second substituents can optionally join to form a cycloalkyl or heterocyclyl group. The dioxirane-containing compound can be used as an oxidant, surfactant, and/or an ionic liquid.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 23, 2014
    Assignee: Empire Technology Development LLC
    Inventor: Kraig Anderson
  • Publication number: 20140275571
    Abstract: Methods, catalysts, and reactor systems for producing in high yield aromatic chemicals and liquid fuels from a mixture of oxygenates comprising di- and polyoxygenates are disclosed. Also disclosed are methods, catalysts, and reactor systems for producing aromatic chemicals and liquid fuels from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like; and methods, catalysts, and reactor systems for producing the mixture of oxygenates from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like. The disclosed catalysts for preparing the mixture of oxygenates comprise a Group VIII metal and a crystalline alumina support.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Virent, Inc.
    Inventors: Taylor Beck, Brian Blank, Casey Jones, Elizabeth Woods, Randy Cortright
  • Patent number: 8834744
    Abstract: The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, X0 and L1-6 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: September 16, 2014
    Assignee: Merck Patent GmbH
    Inventors: Michael Wittek, Brigitte Schuler, Reiffenrath Volker, Mark Goebel, Markus Czanta
  • Patent number: 8828908
    Abstract: Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: September 9, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, Matthew Brian Hotson, Alan John Dowling, James Nicholas Scutt, Mangala Govenkar, Lee Challinor
  • Patent number: 8829210
    Abstract: The present invention provide process of preparation of (2R,3S)—N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5(?)-20-epoxy-1,2(?),4,7(?),10(?),13(?)-hexa hydroxy tax-11-en-9-one 4-acetate 2-benzoate or docetaxel and its trihydrate (I)
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: September 9, 2014
    Assignee: Shilpa Medicare Limited
    Inventors: Vimal Kumar Shrawat, Rafiuddin, Veereshappa, Prashant Purohit
  • Patent number: 8822705
    Abstract: The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R1 and R5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R2, R3, and R4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R5 may be bound on meta-position against heptylene group of another aryl group to form a ring.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: September 2, 2014
    Inventors: Je-Tae Woo, Masato Ohta, Takayuki Yonezama, Toshiaki Teruya, Byung-Yoon Cha, Kazuo Nagai, Toshihiro Akihisa, Hiroyuki Akazawa
  • Patent number: 8785662
    Abstract: The present invention relates to a preservative for preserving wood comprising 5-methyl-2-trifluoromethylfuran-3-carboxylic acid anilide derivative represented by the following formula, wherein R represents an iropropyl group or an isopropoxy group as an active ingredient. The preservative for preserving wood has an excellent preservative effect on various wood-decay fungi at an extremely low dose, is economically efficient, and imposes a small burden on the environment. The present invention also relates to a method for treating wood using the preservative.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: July 22, 2014
    Assignee: SDS Biotech K.K.
    Inventors: Keijitsu Tanaka, Masahiro Maesawa
  • Publication number: 20140187467
    Abstract: A dioxirane-containing compound has a first substituent that is an alkyl, polyalkoxy, aryl, heteroaryl, or heterocyclyl group, and a second substituent that is an electron withdrawing group, and where the first and second substituents can optionally join to form a cycloalkyl or heterocyclyl group. The dioxirane-containing compound can be used as an oxidant, surfactant, and/or an ionic liquid.
    Type: Application
    Filed: July 20, 2012
    Publication date: July 3, 2014
    Inventor: Kraig ANDERSON
  • Patent number: 8754242
    Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: June 17, 2014
    Assignees: Syngenta Crop Protection LLC, Syngenta Limited
    Inventors: Melloney Tyte, Christopher John Matthews, Gavin John Hall, William Guy Whittingham, Jeffrey Steven Wailes, James Nicholas Scutt, Stephane André Marie Jeanmart, Russell Colin Viner
  • Patent number: 8703099
    Abstract: The present invention provides compositions and methods for synthesizing labeled drugs. The present invention further provides methods for preventing or stopping prescription drug abuse for all agents registered as a Drug Enforcement Agency (DEA) schedule II through schedule V medications. According to the present invention, methods are provided for monitoring patient compliance with prescribed drug treatment. The present invention also provides methods for facilitating a replacement prescription when a patient is left without access to their prescribed drug. Furthermore, the present invention provides a method to improve employee compliance with an employer's drug policies via either a voluntary or compulsory system for enhanced drug testing.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: April 22, 2014
    Assignee: DR Pharma Nova, LLC
    Inventors: Alan J. Reis, Christian Schafmeister
  • Patent number: 8691111
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following formula: wherein: R1, R2 are independently aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; R3 and R4 are independently hydrogen, halogen, cyano, alkoxy, NHCOR7, NHSO2R7, COOR7, OCOR7, aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine with either R1 or R2 to form a carbocylic or heterocyclic ring; R5 and R6 are independently hydrogen, CH2, CH, alkyl or aryl either substituted or unsubstituted, COOR7, or combine with L to form a carbocyclic or heterocyclic ring; R7 is aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl or heterocyclic all either substituted or unsubstituted; L is the non-metallic elements required to form a carbocyclic or heterocyclic ring, or a single bond or a double bond; m is 1-3; n is 0-12.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 8, 2014
    Assignee: Kent Displays Inc.
    Inventors: Donald R. Diehl, Thomas Welter, Erica N. Montbach, J. William Doane, Nithya Venkataraman
  • Patent number: 8637496
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 28, 2014
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • Patent number: 8608977
    Abstract: The present invention relates to compounds of the general formula I in which the variables are each defined as follows: W is a (Y4-T2-)s(Y3-A2-)tY2—Z2 moiety, Z1, Z2 are each independently unreactive radicals as defined more specifically in the description or reactive radicals through which polymerization can be brought about, A1, A2 are each independently spacers as defined more specifically in the description, Y1 to Y5 are linking units as defined more specifically in the description, Y6 is a chemical single bond or —CO—, T1, T2 are each independently, as defined more specifically in the description, divalent saturated or unsaturated, optionally substituted and optionally fused iso- or heterocyclic radicals, Q is substituents as defined more specifically in the description, r, t are each independently 0 or 1, s is 0, 1, 2 or 3 and q is 0, 1, 2, 3 or 4.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: December 17, 2013
    Assignee: BASF SE
    Inventors: Olivier Enger, Markus Hoffmann, Jochen Brill, Stephan Maurer, Bernd Ziegler
  • Patent number: 8603357
    Abstract: The present inventions to provide a novel polymerizable chiral compound (chiral agent) having high helical twisting power, a polymerizable liquid crystal composition comprising the polymerizable chiral compound and a polymerizable liquid crystal compound, a liquid crystal polymer, and an optically anisotropic body.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: December 10, 2013
    Assignee: Zeon Corporation
    Inventors: Kei Sakamoto, Kentaro Tamura
  • Patent number: 8586766
    Abstract: A problem to be solved by the present invention is to provide an episulfide compound efficiently from an epoxy compound with no need of a measure against odor or corrosion, or a neutralization step. The present invention solved the above-described problem by a method for producing an episulfide compound in which an epoxy compound and a thiourea are reacted with each other in the presence of an ammonium compound.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: November 19, 2013
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Mineki Kubo, Hiroshi Horikoshi
  • Patent number: 8574456
    Abstract: The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, X0 and L1-6 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: November 5, 2013
    Assignee: Merck Patent GmbH
    Inventors: Michael Wittek, Brigitte Schuler, Volker Reiffenrath, Mark Goebel, Markus Czanta
  • Patent number: 8575367
    Abstract: The present disclosure relates to the preparation of acrylate, alkacrylate, allyl, and polycarbonate derivatives of hydroxy ketal esters, and uses thereof.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: November 5, 2013
    Assignee: Segetis, Inc.
    Inventors: Sergey Selifonov, Brian Daniel Mullen, Douglas Alan Wicks, Vivek Badarinarayana
  • Patent number: 8575183
    Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110? activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lympho
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: November 5, 2013
    Assignee: Amgen Inc.
    Inventors: Timothy David Cushing, Jason A. Duquette, Xiao He, Julia Lohman, Youngsook Shin
  • Patent number: 8563779
    Abstract: A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: October 22, 2013
    Assignee: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Andreas Van Almsick, Elmar Gatzweiler, Dieter Feucht, Isolde Haeuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
  • Patent number: 8558020
    Abstract: The present invention refers to an aqueous hydrogen peroxide solution having a hydrogen peroxide concentration [H2O2] expressed as % by weight of the solution and an apparent pH of from pHmin to pHmax, such that pHmin=3.45?0.0377×[H2O2], and pHmax=3.76?0.0379×[H2O2]. The present invention also relates to a process for the preparation of said hydrogen peroxide solution and the use of said solution in a process for the epoxidation of olefins.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: October 15, 2013
    Assignee: Solvay (Societe Anonyme)
    Inventors: Armin T. Liebens, Jean-Pierre Ganhy, Jean-Pierre Catinat, Koen Vermeiren
  • Patent number: 8541606
    Abstract: A polymer compound for a photoresist composition (a) having a high dissolution rate in a developing solution after exposure and (b) exhibiting little swelling during development. A tertiary alcohol derivative that is a raw material for the polymer compound. A tertiary alcohol that is an intermediate of the tertiary alcohol derivative. The tertiary alcohol is represented by formula (3): wherein R1 and R2 individually represent a linear, branched or cyclic alkylene group having 2 to 9 carbon atoms, which may contain an oxygen atom, and wherein R1 and R2 may together form a ring with a carbon atom to which R1 and R2 are bonded.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 24, 2013
    Assignee: Kuraray Co., Ltd.
    Inventors: Takashi Fukumoto, Ichihiro Aratani
  • Patent number: 8524920
    Abstract: A compound includes a polymer where the polymer includes a pendant dioxirane moiety. Cost-effective, facilitated generation of a polymer including a pendant dioxirane moiety allows for the compound to be disposable or be easily recycled. The compound can be used in air purification and liquid purification to not only remove particulate matter, but also to destroy microorganisms and remove volatile organic compounds.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: September 3, 2013
    Assignee: Empire Technology Development LLC
    Inventors: Angele Sjong, Kraig K. Anderson
  • Patent number: 8524919
    Abstract: A compound includes a polymer where the polymer includes a pendant dioxirane moiety. Cost-effective, facilitated generation of a polymer including a pendant dioxirane moiety allows for the compound to be disposable or be easily recycled. The compound can be used in air purification and liquid purification to not only remove particulate matter, but also to destroy microorganisms and remove volatile organic compounds.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: September 3, 2013
    Assignee: Empire Technology Development LLC
    Inventors: Angele Sjong, Kraig Anderson
  • Patent number: 8507552
    Abstract: The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: August 13, 2013
    Assignee: Regents of the University of Minnesota
    Inventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
  • Patent number: 8501790
    Abstract: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: August 6, 2013
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Zachary Demko, Christopher Borella, Shoujun Chen, Lijun Sun
  • Patent number: 8470879
    Abstract: Fatty acid inhibitors, pharmaceutical compositions including fatty acid inhibitors, methods for using fatty acid inhibitors to treat a variety of diseases, and methods for preparing fatty acid inhibitors are provided herein.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: June 25, 2013
    Assignee: Life Technologies Corporation
    Inventor: Bruce Branchaud
  • Patent number: 8470841
    Abstract: Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, T and Y have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example for the treatment of the metabolic syndrome, insulin resistance, obesity and diabetes.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: June 25, 2013
    Assignee: Sanofi
    Inventors: Gerhard Zoller, Dieter Schmoll, Marco Mueller, Guido Haschke, Ingo Focken
  • Patent number: 8460583
    Abstract: There is provided an electroactive material having Formula I wherein: Q is the same or different at each occurrence and can be O, S, Se, Te, NR, SO, SO2, P, PO, PO2, and SiR2; R is the same or different at each occurrence and can be hydrogen, alkyl, aryl, alkenyl, or alkynyl; R1 through R10 are the same or different and can be hydrogen, alkyl, aryl, halogen, hydroxyl, aryloxy, alkoxy, alkenyl, alkynyl, amino, alkylthio, phosphino, silyl, —COR, —COOR, —PO3R2, —OPO3R2, or CN.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: June 11, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Hong Meng, Dengfu Wang
  • Patent number: 8444877
    Abstract: Provided are liquid crystal compounds and mixtures incorporating the same. The liquid crystal compounds of the invention generally comprise a terminal cyclopentene group, along with at least two other ring groups.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: May 21, 2013
    Assignee: VVI Bright China Ltd.
    Inventors: Xinhua Chen, R. Amaranatha Reddy
  • Patent number: 8440608
    Abstract: The invention relates, in particular to a tetrahydropyran(on) compound which is substituted in position beta with respect to a cycle oxygen of formula (I), wherein a substituent R is a linear alkyl radical in C2:C10 including, (CH3)2CH— or C6H5—(CH2)m—, with m=0 or 1, or formula (II), wherein A is —CH2— or —CO—, in the form of an odorant and to a method for the synthesis thereof by reducing oxo-ester. The use of the inventive compound in composition such as perfumery compositions in the ordinary sense of the term i.e. topic, in particular cosmetic compositions and care products.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: May 14, 2013
    Assignee: V. Mane Fils
    Inventors: Jean Mane, Jean-Jacques Chanot, Martin Schroeder
  • Patent number: 8420837
    Abstract: A stabilized nano-Fe6-iron-crown ether complex is formed by preparing a solution of an iron salt and an olygomer crown compound in dialkylamine or diethylamine. Sodium tetrahydroboron (NaBH4) and dialkylamine or ethylendiamine are added at a temperature of 0-10° C. The mixture is heated to room temperature and boiled, thereby converting the formed iron (II)-borhydride complex (Fe(BH4)2) to a crown ether—iron-hydride complex [CWFe06]·(2H)6. At higher temperature this last complex is converted to the Fe06-crown nanocomposite complex.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: April 16, 2013
    Assignee: Asiacom Group Investments, Inc.
    Inventors: Alimamed L. Shabanov, Elmira M. Ramazanova, Ulviyya A. Gasanova
  • Patent number: 8410164
    Abstract: A compound represented by the formula (I) (R1 represents an aryl group such as hydroxyphenyl group, R2 represents 2-carboxyphenyl group etc., and R3 and R4 represent —(CH2)p—N(R5)(R6) (R5 and R6 represent —(CH2)n—COOH), a salt thereof, or an ester thereof, which is useful as a reagent for highly sensitive measurement of reactive oxygen such as hydroxy radical present at a trace amount in living bodies or tissues by a bioimaging technique over a long period of time.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: April 2, 2013
    Assignee: The University of Tokyo
    Inventors: Tetsuo Nagano, Yasuteru Urano, Saki Izumi
  • Patent number: 8378056
    Abstract: New polyols; oligomers, and polymers made from the polyols; and binders made from the new polyols, oligomers, or polymers that can be used in binders, where the binders typically include one or more polyols, and a polyfunctional acid or a polyfunctional nitrile.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: February 19, 2013
    Assignee: Battelle Memorial Institute
    Inventors: Herman P. Benecke, Daniel B. Garbark, Alex W. Kawczak, Michael C. Clingerman
  • Patent number: 8372994
    Abstract: Glycidyl 2-propylheptanoate, glycidyl 4-methyl-2-propylhexanoate or a mixture of these (referred to collectively for short as glycidyl ester).
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: February 12, 2013
    Assignee: BASF SE
    Inventors: Kai Gumlich, Roland Merten, Michael Henningsen, Martin Schaefer, Joaquim Henrique Teles, Bernhard Mohr
  • Patent number: 8362072
    Abstract: A pharmaceutical composition for use in treating, inhibiting, and/or preventing breast and/or ovarian cancer can include: a molecule having a structure of one of Compounds 1-38, pharmaceutically acceptable salt thereof, or analog thereof; and a pharmaceutically acceptable carrier containing the compound. The pharmaceutically acceptable carrier can be configured for oral, systemic, transdermal, intranasal, suppository, parenteral, intramuscular, intravenous, or subcutaneous administration. The compound can be present in the composition in a therapeutically effective amount for treating, inhibiting, and/or preventing breast and/or ovarian cancer. Also, the compound can be present in a therapeutically effective amount for enhancing production of BRCA1.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: January 29, 2013
    Assignee: University of Kansas
    Inventors: Roy A. Jensen, Lisa M. Harlan-Williams, Frank J. Schoenen, Jeffrey Aube, Gerald H. Lushington
  • Patent number: 8309676
    Abstract: New polyols; oligomers, and polymers made from the polyols; and binders made from the new polyols, oligomers, or polymers that can be used in binders, where the binders typically include one or more polyols, and a polyfunctional acid or a polyfunctional nitrile.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: November 13, 2012
    Assignee: Battelle Memorial Institute
    Inventors: Herman P. Benecke, Daniel B. Garbark, Alex W. Kawczak, Michael C. Clingerman
  • Patent number: 8269001
    Abstract: A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is performed early in the course of synthesis.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: September 18, 2012
    Assignee: Lek Pharmaceuticals d.d.
    Inventor: Zdenko Casar
  • Patent number: 8263791
    Abstract: A convenient, rapid, and highly sensitive protein detection method is provided. According to the present invention, an easily water-soluble compound of formula I is provided: [wherein, R1 and R2 are same or different, each of which is an aryl or heteroaryl group substituted with one or more anionic substituents].
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: September 11, 2012
    Assignees: National Institute of Advanced Industrial Science and Technology, Kanto Kagaku Kabushiki Kaisha
    Inventors: Yoshio Suzuki, Kenji Yokoyama, Nobuyuki Takagi, Tomoyuki Chimuro, Atsushi Shinohara
  • Publication number: 20120215012
    Abstract: A method for purifying tetrahydrofuran from a liquid containing tetrahydrofuran and as impurities at least water, 2,5-dihydrofuran and butanol, the method comprising: a first distillation step in which the liquid is subjected to distillation using a distillation column to separate into a first bottoms product containing water as a major component and a first distillate containing tetrahydrofuran, 2,5-dihydrofuran and butanol as major components, a second distillation step in which the first distillate is subjected to distillation using a distillation column to separate into a second bottoms product containing tetrahydrofuran and butanol as major components and a second distillate containing 2,5-dihydrofuran as a major component, a third distillation step in which the second bottoms product is subjected to distillation using a distillation column to separate into a third bottoms product containing butanol as a major component and a third distillate containing tetrahydrofuran as a major component, and further c
    Type: Application
    Filed: October 30, 2009
    Publication date: August 23, 2012
    Inventors: Toshiaki Matsuo, Kenichiro Oka, Masayuki Kamikawa, Takeyuki Kondo, Hiroyuki Ito, Yasunari Sase, Chiaki Watanabe, Tetsuji Harigai
  • Patent number: 8212055
    Abstract: A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing the tetrahydrobilene to form a chlorin. Intermediates including tetrahydrobilenes useful in such reactions are also described.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: July 3, 2012
    Assignee: North Carolina State University
    Inventors: Jonathan S. Lindsey, Masahiko Taniguchi, Doyoung Ra, Guoning Mo, Thiagarajan Balasubramanian