Polycyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/23)
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Patent number: 7816476Abstract: Cyclopropyl acrylate of general formula (1), constitutional and stereoisomers thereof and their mixtures in which A is selected from:Type: GrantFiled: August 9, 2005Date of Patent: October 19, 2010Assignee: Ivoclar Vivadent AGInventors: Norbert Moszner, Frank Zeuner, Urs-Karl Fischer, Volker M. Rheinberger, Armin de Meijere, Viktor Bahutski
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Patent number: 7767832Abstract: Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.Type: GrantFiled: December 20, 2004Date of Patent: August 3, 2010Assignee: SK Holdings Co., Ltd.Inventors: Jae Suk Koh, Chun Young Kim, Byoung In Lee, Sang Soo Lee, Seong Jun Lee, Jong Ho Lim, Seon Yeong Jeon, Jun Bae Hong
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Patent number: 7763646Abstract: The invention relates to compounds of formula (I). Useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.Type: GrantFiled: September 26, 2003Date of Patent: July 27, 2010Assignee: Elan Pharmaceuticals, Inc.Inventors: Roy Hom, Varghese John
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Publication number: 20100173774Abstract: Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides.Type: ApplicationFiled: March 7, 2008Publication date: July 8, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Michel Muehlebach, William Lutz, Jean Wenger, John Finney, Christopher John Matthews, Delphine Fawke
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Publication number: 20100167927Abstract: The invention relates to substituted amino-thiourea compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to the use of the substituted amino-thiourea compounds, of their salts or of compositions comprising them for combating animal pests. Furthermore the invention relates also to methods of applying such compounds. The substituted amino-thiourea compounds are defined by the following formula (I): wherein A, B, R1, R2, R3, R4, R5.1, R5.2 and R6 are defined as in the description.Type: ApplicationFiled: May 13, 2008Publication date: July 1, 2010Applicant: BASF SEInventors: Christopher Koradin, Markus Kordes, Ernst Baumann, Ronan Le Vezouet, Deborah L. Culbertson
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Publication number: 20100135906Abstract: Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18F, 123I, 124I, 125I, or 11C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.Type: ApplicationFiled: March 31, 2008Publication date: June 3, 2010Inventors: Jorge R. Barrio, Vladimir Kepe, Small W. Gary, Nagichettiar Satyamurthy
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Publication number: 20100130737Abstract: The present invention provides a GPR receptor function regulator comprising the compound represented by the formula: [wherein ring A is an optionally substituted isocyclic or heterocyclic ring, P is a bond or spacer, ring D is an optionally substituted monocyclic aromatic ring which may be condensed with a 5- to 7-membered ring, V is a bond or the group represented by the formula —CR14?CR15— or —N?CR16— (wherein R14, R15 and R16 each represents a hydrogen atom or optionally substituted hydrocarbon group), Q is a bond or spacer, and W is a carboxyl or a group biologically equivalent to a carboxyl] or its salt or a prodrug thereof.Type: ApplicationFiled: February 17, 2006Publication date: May 27, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Fumio Itoh, Eiji Kimura, Yumi Imai, Masaaki Mori, Yoshio Aramaki, Yasuhisa Kohara, Tsukasa Sugo, Yoji Hayase, Hiromi Kobayashi, Kazuhiro Ogi
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Publication number: 20100125067Abstract: The present invention relates to new sulfonamide inhibitors of carbonic anhydrase II, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: November 19, 2009Publication date: May 20, 2010Applicant: AUSPEX PHARMACEUTICALS, INC.Inventor: Thomas G. Gant
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Publication number: 20100113804Abstract: There is provided a process for preparing dorzolamide and processes for preparing intermediates useful in the preparation of dorzolamide. In particular, there is provided a process for preparing an acetoamido sulfone of formula (viii) comprising oxidation of a hydroxysulfonamide of formula (vii) in the presence of an oxidizing agent selected from the group consisting of: a peracid, tert-butyl hydroperoxide, dimethyl dioxirane, selenium dioxide, m-phenanthroline di-N-oxide, nitric acid and hydrogen peroxide. There is also provided a process for preparing an acetoamidosulfone of formula (ix-a) comprising converting a hydroxy sulfone of formula (viii) to the acetoamidosulfone of formula (ix-a) in the presence of acetonitrile and an acid. There is also provided a process for separating the cis- and trans-isomers of dorzolamide from a mixture of the trans-isomer of dorzolamide and the cis-isomer of dorzolamide comprising reacting the mixture of isomers with a carboxylic acid.Type: ApplicationFiled: May 7, 2008Publication date: May 6, 2010Applicant: CIPLA LIMITEDInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Shrikant Suresh Mudgal
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Publication number: 20100099688Abstract: The present invention relates to a compound according to formula I, wherein X, A, G, E, R1, R2, R3 are as shown herein; and pharmaceutically acceptable salts, hydrates, N-oxides or solvates hereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.Type: ApplicationFiled: February 26, 2008Publication date: April 22, 2010Applicant: Leo Pharma A/SInventors: Jakob Felding, Simon Feldbaek Nielsen, Jens Christian Højland Larsen, Bollu Ravindra Babu
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Publication number: 20100063035Abstract: Nitroderivatives of dorzolamide and brinzolamide having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma, ocular hypertension, age-related macular degeneration, diabetic macular edema, diabetic retinopathy, hypertensive retinopathy and retinal vasculopathies.Type: ApplicationFiled: December 3, 2007Publication date: March 11, 2010Applicant: Nicox S.A.Inventors: Francesca Benedini, Stefano Biondi, Ennio Ongini
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Publication number: 20100048667Abstract: This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-? activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.Type: ApplicationFiled: May 26, 2009Publication date: February 25, 2010Inventors: Barbara S. SLUSHER, Takashi TSUKAMOTO
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Publication number: 20090291923Abstract: The invention provides novel trioxane dimers having formulae III, IV or V: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer and/or malaria using these compounds and compositions.Type: ApplicationFiled: November 17, 2006Publication date: November 26, 2009Applicants: Johns Hopkins Universoty, The Government of the United States of America as Represented by the Secretary of the DHHS NIH, OffiInventors: Gary H. Posner, Ikhyeon Paik, Kristina Borstnik, Wonsuk Chang, Sandra Sinishtaj, William Malo, John Gaetano D'Angelo, Lauren Elaine Woodard, Alvin Solomon Kalinda, Aimee R. Usera, Lindsey Catherine Hess, Andrew Scott Rosenthal, Seongho Oh, Astrid C. Baege
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Publication number: 20090275759Abstract: A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S)-(+)-10-camphorsulfonic acid so obtaining the (4S,6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate), and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.Type: ApplicationFiled: April 16, 2007Publication date: November 5, 2009Applicant: ZACH SYSTEM S.P.A.Inventors: Paolo Maragni, Ivan Michieletto, Livius Cotarca
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Publication number: 20090270367Abstract: The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.Type: ApplicationFiled: March 3, 2009Publication date: October 29, 2009Inventors: Varghese JOHN, Michel MAILLARD, John TUCKER, Jose AQUINO, Barbara JAGODZINSKA, Louis BROGLEY, Jay TUNG, Simeon BOWERS, Darren DRESSEN, Gary PROBST, Neerav SHAH
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Publication number: 20090264662Abstract: The present invention relates to resolution of (cis, trans) 5,6-dihydro-4H-4-ethylamino-6-methylthieno[2,3-b] thiopyran-2-sulfonamide-7,7-dioxide using dibenzoyl-L-tartaric acid monohydrate or di-p-toluoyl-L-tarrtaric acid monohydrate as a chiral resolving agent in presence of methanol to obtain hemitartarate salt, purifying it to obtain hemitartarate salt of 5,6-dihydro-4 H-4 (S)-ethyl amino-6(S) methylthieno [2,3-b] thiopyran-2-sulfonamide-7,7-dioxide with de of >99% , Chemical purity >99.5% with cis isomer content of <0.1% and further converting into its pharmaceutically acceptable salts, preferably hydrochloride salt.Type: ApplicationFiled: July 6, 2005Publication date: October 22, 2009Applicant: FDC LTDInventors: Anand Mohan Chandavarkar, Rajaram Uday Bapat, Anand Atul Bade, Anand Pandurang Chavan
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Publication number: 20090234140Abstract: Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.Type: ApplicationFiled: December 20, 2004Publication date: September 17, 2009Applicant: SK CORPORATIONInventors: Jae Suk Koh, Chun Young Kim, Byoung In Lee, Sang Soo Lee, Seong Jun Lee, Jong Ho Lim, Seon Yeong Jeon, Jun Bae Hong
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Patent number: 7576213Abstract: A hitherto unknown class of chemical compounds, 2H-furo[2,3-c]pyran-2-ones including derivatives and analogues thereof are disclosed herein. Methods for making compounds within said class are disclosed herein and includes, without limitation, at least the intermediates employed in the generation of said compounds. The invention also relates to the use of vinylogous 4H-pyrones, including but not limited to the hitherto unknown 2H-furo[2,3-c]pyran-2-ones. Disclosed herein are methods comprising the step of exposing biological plant material to at least a compound of the invention to promoting bioactivity within said material. In another aspect in methods for promoting growth of plant material in, for example, smoke-responsive plant species by exposing said material to a compound of the invention are disclosed herein. More specifically, methods comprising the use of these compounds for promoting seed germination of a plant, for example, a smoke-responsive plant, are disclosed herein.Type: GrantFiled: June 19, 2006Date of Patent: August 18, 2009Assignee: The University of Western AustraliaInventors: Gavin Ray Flematti, Emilio Luciano Ghisalberti, Kingsly Wayne Dixon, Robert Donald Trengove
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Publication number: 20090192151Abstract: Disclosed herein are compounds useful in treating glaucoma, inflammatory bowel disease, the stimulation of hair growth, and the stimulation of the conversion of vellus hair to terminal hair. The compounds themselves are herein.Type: ApplicationFiled: January 14, 2009Publication date: July 30, 2009Inventors: David W. Old, Danny T. Dinh
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Patent number: 7544717Abstract: Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.Type: GrantFiled: March 25, 2005Date of Patent: June 9, 2009Assignee: Elan Pharmaceuticals, Inc.Inventors: Roy Hom, John Tucker, Varghese John, Neerav Shah
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Publication number: 20090137821Abstract: Processes for the preparation of dorzolamide hydrochloride and an intermediate of Formula IV, are provided.Type: ApplicationFiled: December 22, 2008Publication date: May 28, 2009Inventors: Laszlo Zsolt Kovacs, Csaba Szabo, Erika Magyar Molnarne, Adrienne Kovacsne-Mezei, Claude Singer, Judith Aronhime
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Publication number: 20090092624Abstract: The present invention relates in part to antiinfective flavononol compounds represented by formula I: Another aspect of the invention is a method for treating an infection in a subject by administering the compounds of Formula I to the subject.Type: ApplicationFiled: August 15, 2008Publication date: April 9, 2009Inventors: Randall S. Alberte, William P. Roschek, JR.
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Publication number: 20090087575Abstract: The invention provides an ink composition including (i) a sensitizing dye having a polymerizable group as a substituent, (ii) a polymerization initiator and (iii) a polymerizable compound having an ethylenically unsaturated bond. The invention also provides an inkjet recording method and a polymerizable compound useful as a sensitizing dye. The sensitizing dye (i) is represented by Formula (I) or (II) below. In the formulae, X represents O, S, NRa, or NRb, n1 and n2 each represent 0 or 1, Ra, Rb, and R1 to R18 each represent a hydrogen atom or a monovalent substituent, and one polymerizable group is present in the molecule.Type: ApplicationFiled: September 9, 2008Publication date: April 2, 2009Applicant: FUJIFILM CORPORATIONInventors: Tokihiko MATSUMURA, Tsutomu Umebayashi
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Publication number: 20090076287Abstract: The invention is aimed at a compound of formula (I) wherein n is 0, 1 or 2, R1 is a linear or branched alkyl group, R2 is selected from a substituted or non substituted alkyl group, substituted or non substituted aryl group, substituted or non substituted aralkyl group, substituted or non substituted heterocyclyl group, or a substituted or non substituted heterocyclylalkyl group. Another object of the invention is a process for obtaining these compounds from the corresponding compound with a hydroxy group in position 4 by means of reacting with a sulfonamide in the presence of a phosphine and a dialkyl azadicarboxylate. The deprotection of the compound of formula (I) gives rise to the corresponding amine. The intermediate and the processes described are very useful in the synthesis of pharmaceutical products.Type: ApplicationFiled: November 4, 2005Publication date: March 19, 2009Applicant: RAGACTIVES, S.L.Inventors: Jose Maria Gorgojo Lobato, Luis Octavio Silva Guisasola, Jorge Martin Juarez
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Publication number: 20090076076Abstract: The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.Type: ApplicationFiled: June 13, 2008Publication date: March 19, 2009Applicant: Baylor UniversityInventors: Rogelio Siles, Ming Zhou, J. Freeland Ackley, Kevin G. Pinney, Shen-En Chen, Wara Milenka Arispe-Angulo, Mary Lynn Trawick
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Patent number: 7495111Abstract: 3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT1A receptor (agonizing or antagonizing) in a patient. These compounds are further useful for inhibiting binding to a serotonin receptor. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.Type: GrantFiled: June 15, 2006Date of Patent: February 24, 2009Assignee: WyethInventors: P. Sivaramakrishnan Ramamoorthy, Zhongqi Shen, Boyd L. Harrison
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Patent number: 7488494Abstract: Isoflavone compounds are described and recommended as therapeutic agents. Exemplified and preferred compounds are (a). Indications show compounds have good competitive binding to estrogen receptors.Type: GrantFiled: November 7, 2003Date of Patent: February 10, 2009Assignee: Novogen Research Pty Ltd.Inventors: Andrew Heaton, Naresh Kumar, Graham Edmund Kelly, Alan Husband
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Publication number: 20090018149Abstract: Described are 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of mycobacteria-induced infections and opportunistic infections, as well as compositions containing at least one 4,5,6,7-tetrahydrobenzo[b]thiophene derivative and/or pharmaceutically acceptable salts thereof. Furthermore, the present application refers to the use of mycobacterial protein serine/threonine kinases for developing methods for detection and determination of these kinases for recognising and monitoring diseases and for controlling therapy of diseases.Type: ApplicationFiled: April 9, 2003Publication date: January 15, 2009Inventors: Andrea Missio, Gerald Bacher, Anil Koul, Axel Choidas, Peter Banhegyi, Zoltan Greff, Gyorgy Keri, Peter Marko, Laszlo Orfi, Janos Pato, Frigyes Waczek
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Patent number: 7476673Abstract: Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RAR? agonist retinoids, such as skin related diseases, including but not limited to acne and psoriasis.Type: GrantFiled: December 17, 2004Date of Patent: January 13, 2009Assignee: Allergan, Inc.Inventors: Kwok Yin Tsang, Santosh Sinha, Xiaoxia Liu, Smita Bhat, Roshantha A. Chandraratna
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Patent number: 7468360Abstract: Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.Type: GrantFiled: August 8, 2007Date of Patent: December 23, 2008Assignee: Allergan, Inc.Inventors: David W. Old, Danny T. Dinh
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Publication number: 20080312310Abstract: Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed.Type: ApplicationFiled: September 27, 2007Publication date: December 18, 2008Inventors: Han-Jie Zhou, Andrew McDonald
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Publication number: 20080306136Abstract: The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.Type: ApplicationFiled: April 1, 2008Publication date: December 11, 2008Inventors: Shon R. Pulley, John A. Tucker
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Patent number: 7435455Abstract: A dihydrocoumarin ring-containing compound of the invention is represented by the following formula (1): wherein R represents hydrogen or an alkyl; A1 to A3 each represents 1,4-cyclohexylene or 1,4-phenylene; Z1 to Z3 each represents a single bond, —(CH2)2—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, —CH?CH—, —CF?CF—, —C?C—, —(CH2)4—, —O(CH2)2O—, —(CH2)2CF2O—, —(CH2)2OCF2—, —CF2O(CH2)2—, —OCF2(CH2)2—, —CH?CH—CH2O—, or —OCH2—CH?CH—; X represents hydrogen, fluorine, chlorine, —CN, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2, or —OCH2F; G represents oxygen or sulfur; and n and m each represents 0, 1, or 2.Type: GrantFiled: December 16, 2005Date of Patent: October 14, 2008Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventors: Atsuko Fujita, Kouki Sago
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Patent number: 7414143Abstract: An improved process for the preparation of key intermediates for tazarotene, 4,4-dimethyl-6-ethynylthiochroman, is provided comprising (a) reacting 4,4-dimethyl-6-acetylthiochroman of the formula with an acid chloride and an amido-group containing compound of the general formula wherein R is hydrogen or a hydrocarbyl of from 1 to 15 carbon atoms and R1 and R2 can be the same or different and are hydrocarbyls of from 1 to 15 carbon atoms or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms, or one of R1 and R2 together with the nitrogen atom to which it bonded are joined together with the carbonyl radical to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms to form a ?-chloro vinyl carbonyl compound intermediate of the general formula wherein R has the aforestated meanings; and (b) reacting the ?-chloro vinyl carbonyl compoundType: GrantFiled: June 22, 2005Date of Patent: August 19, 2008Assignee: Glenmark Pharmaceuticals LimitedInventors: Bobba Venkata Siva Kumar, Vishvas Dattatraya Patil, Changdev Namdev Raut, Shekhar Bhaskar Bhirud, Batchu Chandrasekhar
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Substituted Benzo-Condensed Cycloheptanone Derivatives and the Use Thereof for Medicament Production
Publication number: 20080161352Abstract: The invention relates to substituted benzo-condensed cyclohexanone derivatives, to a method for the production thereof, to medicaments containing said derivatives and to the use of the inventive compounds for producing medicaments.Type: ApplicationFiled: May 17, 2006Publication date: July 3, 2008Applicant: Gruenenthal GmbHInventors: Robert Frank, Michael Przewosny, Ruth Jostock -
Publication number: 20080161520Abstract: The present invention relates to a heterocycle-containing onium salt useful as, for example, a cationic photopolymerization initiator and an acid generator for a chemically amplified resist, and provides a heterocycle-containing onium salt shown in the specification.Type: ApplicationFiled: November 20, 2007Publication date: July 3, 2008Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.Inventors: Masami Ishihara, Yoji Urano, Masahiro Takahashi
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Publication number: 20080026478Abstract: Coumarine/chinolone and Martina-type compounds, compositions, and method of using the compounds and compositions for protein detection, assay, quantitation, etc. are disclosed. The composition, also referred to as a dye, has enhanced sensitivity over commercially available protein stains, and may be used to stain proteins in solution, proteins separated on gels, proteins transferred to solid supports, etc.Type: ApplicationFiled: July 28, 2006Publication date: January 31, 2008Applicant: PIERCE BIOTECHNOLOGY, INC.Inventors: Peter T. Czerney, Surbhi Desai, Frank G. Lehmann, Zakir S. Murtaza, Bernd G. Schweder, Matthias S. Wenzel, Brian David Wolf
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Patent number: 7318991Abstract: The present invention relates to a heterocycle-containing onium salt useful as, for example, a cationic photopolymerization initiator and an acid generator for a chemically amplified resist, and provides “a heterocycle-containing onium salt shown in the specification.Type: GrantFiled: October 11, 2002Date of Patent: January 15, 2008Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Masami Ishihara, Yoji Urano, Masahiro Takahashi
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Patent number: 7301705Abstract: The alicyclic compound of the present invention has a five- or more membered ring structure having an epithioethylene linkage and/or an epidithioethylene linkage, and has tow or more sulfur atoms in its molecule. Optical materials produced by curing the alicyclic compound or a composition containing the alicyclic compound by polymerization show high refractive index.Type: GrantFiled: June 11, 2002Date of Patent: November 27, 2007Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Yuichi Yoshimura, Motoharu Takeuchi, Teruo Kamura
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Patent number: 7294650Abstract: Compounds of formula (I): and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective ?2-adrenoreceptor agonist is indicated, for example asthma or chronic obstructive pulmonary disease (COPD).Type: GrantFiled: December 15, 2004Date of Patent: November 13, 2007Assignee: Glaxo Group LimitedInventor: Keith Biggadike
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Patent number: 7282502Abstract: The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.Type: GrantFiled: March 28, 2006Date of Patent: October 16, 2007Assignee: Millennium Pharmaceuticals, Inc.Inventors: Paul Fleming, Geraldine C. B. Harriman, Zhan Shi, Chen Shaowu
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Patent number: 7259271Abstract: Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1, and a method for their preparation. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.Type: GrantFiled: September 20, 2006Date of Patent: August 21, 2007Assignee: Portela & C.A., S.A.Inventors: David Alexander Learmonth, Patricio Manuel Viera Araújo Soares da Silva, Alexander Beliaev
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Patent number: 7253319Abstract: Compounds of the formula where the variables have the values described in the specification are antagonists of RAR? retinoid receptors.Type: GrantFiled: December 23, 2004Date of Patent: August 7, 2007Assignee: Allergan, Inc.Inventors: Kwok Yin Tsang, Santosh Sinha, Xiaoxia Liu, Smita Bhat, Roshantha A. Chandraratna
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Patent number: 7230121Abstract: The present invention relates to sulfonium salts, to methods for their preparation and to radiation curable compositions containing them as photoinitiators.Type: GrantFiled: July 4, 2002Date of Patent: June 12, 2007Assignee: Lamberti SpAInventors: Gabriele Norcini, Angelo Casiraghi, Marco Visconti, Giuseppe Li Bassi
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Patent number: 7223774Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.Type: GrantFiled: April 21, 2004Date of Patent: May 29, 2007Assignee: Elan Pharmaceuticals, Inc.Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
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Patent number: 7196081Abstract: The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general formula (1): in which R1 represents a hydrogen atom, etc., R2 represents a C1–C7 halogenoalkyl group, etc., m represents an integer of 2 to 14, and n represents an integer of 2 to 7, or enantiomers of the compound, or hydrates or pharmaceutically acceptable salts of the compound or enantiomers thereof. The above compound is advantageous in pharmaceutical use because the group of general formula (1) allows compounds such as anti-estrogenic ones to show a significantly increased activity following oral administration when attached to the parent scaffolds of the compounds.Type: GrantFiled: October 29, 2002Date of Patent: March 27, 2007Assignee: Chugai Seiyaku Kabushiki KaishaInventors: JaeChon Jo, HeeAn Kwon, HyunSuk Lim, JaeYoung Choi, Kazumi Morikawa, Yoshitake Kanbe, Masahiro Nishimoto, MyungHwa Kim, Yoshikazu Nishimura
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Patent number: 7138411Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I? wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.Type: GrantFiled: November 22, 2002Date of Patent: November 21, 2006Assignee: G.D. Searle & Co.Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte
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Patent number: 7109353Abstract: The present invention relates to an improved process for the preparation of 5,6-dihydro-4-(S)-(ethylamino)-6-(S)methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide hydrochloride of formula (I) commonly known as Dorzolamide Hydrochloride useful as an agent to reduce intraoccular pressure by inhibiting carbonic anhydrase enzymeType: GrantFiled: December 28, 2004Date of Patent: September 19, 2006Assignee: Council of Scientific and Industrial ResearchInventors: Mukund Keshao Gurjar, Madhusudan Nagorao Deshmukh, Vincent Paul, Venkatasubramaniam Radhakrishnan Tarur, Dhananjay Govind Sathe, Santosh Pratap Pardeshi, Sanjay Janardhan Naik, Tushar Anil Naik
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Patent number: 7101998Abstract: Compounds of formula (I): [in which: R1 represents a direct bond, an oxygen atom, a group >CH2, a sulphur atom, a group >C?O, a group —(CH2)2— or a group of formula —N—Ra, where Ra is hydrogen or an alkyl; R4, R5, R6 and R7 are each hydrogen or various groups or atoms; R8, R9, R10 and R11 are each hydrogen, hydroxy, or alkyl; or R9 and R11 form a fused ring system with the benzene rings to which they are attached; R12 is a direct bond, oxygen atom or methylene; and X? is an anion; and esters thereof] are useful as cationic photoinitiators, especially for use in surface coating applications, such as printing inks and varnishes, and which are intended to be cured by polymerisation initiated by radiation.Type: GrantFiled: February 26, 2003Date of Patent: September 5, 2006Assignee: Sun Chemical CorporationInventors: Shaun Lawrence Herlihy, Robert Stephen Davidson, Brian Rowatt
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Patent number: 7074819Abstract: The present invention relates to a novel benzopyran or thiobenzopyran derivative represented by formula (1): pharmaceutically acceptable salt or stereoisomer thereof, in which X, R1, R2, R3, R4 and A are defined as described in the specification, and to a process for preparation thereof and a pharmaceutical composition having anti-estrogenic activity which contains the compound (1) as an active component.Type: GrantFiled: August 12, 2003Date of Patent: July 11, 2006Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Jae Chon Jo, Hyun Suk Lim, Jong Min Kim, Ju Su Kim, Kazumi Morikawa, Yoshitake Kanbe, Myung Hwa Kim, Masahiro Nishimoto