Tricyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/359)
Three or more ring oxygens in the tricyclo ring system (e.g., actinospectacin, etc.) (Class 549/361)
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Patent number: 10522761Abstract: Provided are a compound for an organic optoelectronic device represented by Chemical Formula 1, an organic light emitting diode including the same, and a display device including the organic light emitting diode. The structure of Chemical Formula 1 is shown in the specification. The compound for an organic optoelectronic device provides an organic light emitting diode having life-span characteristics due to excellent electrochemical and thermal stability, and having high luminous efficiency at a low driving voltage.Type: GrantFiled: February 19, 2015Date of Patent: December 31, 2019Assignee: SAMSUNG SDI CO., LTD.Inventors: Dong-Wan Ryu, Eui-Su Kang, Han-Ill Lee, Sung-Hyun Jung, Young-Kyoung Jo, Mi-Young Chae, Dal-Ho Huh, Jin-Seok Hong
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Patent number: 9492367Abstract: The present invention relates to a mixture comprising or consisting of a) 2,2-Dimethyl-3-(3-methylphenyl)-propanol (Majantol) b) 4,4a,5,9b-Tetrahydro-2,4-dimethylindenol[1,2-d]-m-dioxin (Magnolan) and optionally, one, two, three or all of the compounds selected from the group consisting of: c) 2-Isobutyl-4-methyltetrahydro-2H-pyran-4-ol (Florosa) d) Citronellyloxyacetaldehyde (Mugenal) e) 4-n-decylpyridine (Symmarine) f) 4-(4-methyl-3-penten-1-yl)-3-cyclohexene carboxaldehyde (Vertomugal), to a fragrance composition containing an organoleptically effective amount of said mixture and to a perfumed product containing said mixture or said fragrance composition and to a method of imparting an odor to a product or enhancing an odor of a product by adding to the product or incorporating into the product an organoleptically effective amount of a mixture or a fragrance composition according to the invention.Type: GrantFiled: October 5, 2010Date of Patent: November 15, 2016Assignee: Symrise AGInventors: Wilhelm Wiedmann, Marcus Betzer, Susanne Borchert, Stefan Lambrecht
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Publication number: 20150111889Abstract: The present invention relates to compounds of the formula (I), wherein the residues A, R1 to R5, Z1 and Z2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds for use in the treatment of diverse disorders, for example cardiovascular disorders like thromboembolic diseases or restenoses. The compounds of the invention are effective antagonists of the platelet LPA receptor LPAR5 (GPR92) and can in general be applied in conditions in which an undesired activation of the platelet LPA receptor LPAR5, the mast cell LPA receptor LPAR5 or the microglia cell LPA receptor LPAR5 is present or for the cure or prevention of which an inhibition of the platelet, mast cell or microglia cell LPA receptor LPAR5 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them.Type: ApplicationFiled: May 16, 2013Publication date: April 23, 2015Applicant: SANOFIInventors: Marc Nazare, Detlef Kozian, Martin Bossart, Werngard Czechtizky, Andreas Evers
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Patent number: 8980586Abstract: An object of the present invention is to provide a novel compound useful as an antifungal substance and a method for producing the compound.Type: GrantFiled: October 22, 2012Date of Patent: March 17, 2015Assignees: The Ritsumeikan Trust, National University Corporation Shizuoka UniversityInventors: Nobutaka Imamura, Kazuya Nakagawa, Shinji Tokuyama
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Publication number: 20140309438Abstract: An object of the present invention is to provide a novel compound useful as an antifungal substance and a method for producing the compound.Type: ApplicationFiled: October 22, 2012Publication date: October 16, 2014Applicants: THE RITSUMEIKAN TRUST, NATIONAL UNIVERSITY CORPORATION SHIZUOKA UNIVERSITYInventors: Nobutaka Imamura, Kazuya Nakagawa, Shinji Tokuyama
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Patent number: 8853263Abstract: The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.Type: GrantFiled: May 18, 2007Date of Patent: October 7, 2014Assignee: Janssen Pharmaceutica NVInventors: Virginia L. Smith-Swintosky, David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
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Patent number: 8658706Abstract: One embodiment includes methods of adding two sulfonic acid groups to molecules having at least two cyclic groups.Type: GrantFiled: April 29, 2011Date of Patent: February 25, 2014Assignee: GM Global Technology Operations LLCInventors: Thomas J. Chapaton, Tenneille Weston Capehart, Armand Soldera, Claude Spino, Riadh Zriba, Gail Capehart
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Publication number: 20140039204Abstract: The effects on human hair growth of 7?-phloroeckol (1-(3?,5?-dihydroxyphenoxy)-7-(2?,4?,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin) isolated from E. cava (Ecklonia cava) have been studied in cell systems. The cell-proliferation and anti-apoptotic effects on human human hair follicle dermal papilla cells (HFDPC) and human keratinocytes (human epidermal keratinocytes: HaCaT) were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot. The 7?-phloroeckol significantly increased HFDPC and HaCaT proliferation. With HFDPC and HaCaT, the amount of PI3K and phosphorylated AKT protein expression increased in a way which was dependent on the extent of 7?-phloroeckol treatment. Also, the levels of MEK½, phosphorylated ERK and c-Fos proteins, which are associated with cell proliferation, increased in a way which was dependent on the extent of 7?-phloroeckol treatment.Type: ApplicationFiled: March 24, 2011Publication date: February 6, 2014Applicant: PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATIONInventors: Se-Kwon Kim, Soon-Sun Bak
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Patent number: 8641797Abstract: The method of the present disclosure includes providing an organic compost material, combining the organic compost material with a crop to be grown, heating the organic compost material, combining the organic compost material with water, and extracting an aqueous liquid comprising humic acid and fulvic acid. The organic compost material may include straw and manure and the straw and manure may be subjected to several days and/or weeks of aerobic composting. The crop may include a variety of plants, trees, vegetables, fruits and fungi. In one embodiment, the crop may include mushroom spores, mycelia, or mushrooms.Type: GrantFiled: June 28, 2012Date of Patent: February 4, 2014Assignee: Black Dirt Organics Patent ManagementInventors: Don Calvin Van Dyke, Asa Staples Nielson, Bruce Sutton, Dan Davies, Loyal B. Adams
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Publication number: 20130338217Abstract: There is provided an antibiotic composition including Eisenia bicyclis-derived phlorotannin compound, in which the antibiotic composition includes a phlorotannin compound selected from 7-phloroeckol, fucofuroeckol-A, and dioxinodehydroeckol, or mixture thereof, which are derived from Eisenia bicyclis, as an effective component. The compounds described above exhibit an antibiotic activity against an antibiotic-resistant bacterium. In addition, the compound described above can exhibit a synergetic effect by using in combination with ?-lactam-based antibiotic composition by recovering an antibiotic activity of ?-lactam-based antibiotic, such as ampicillin, penicillin, and oxacillin against MRSA.Type: ApplicationFiled: October 30, 2012Publication date: December 19, 2013Applicant: Pukyong National University Industry-University Cooperation FoundationInventors: Se-Kwon KIM, Young-Mog Kim, Myung-Suk Lee, Sung-Hwan Eom
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Publication number: 20130336993Abstract: Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease expression of Foxp3.Type: ApplicationFiled: January 18, 2013Publication date: December 19, 2013Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Howard Weiner, Francisco J. Quintana
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Patent number: 8580979Abstract: Humic Acid is extracted and then can be used to treat flue gas and fly ash from the combustion of coal or municipal waste. The resulting product may be used as a soil ameliorant.Type: GrantFiled: January 21, 2013Date of Patent: November 12, 2013Assignee: Organocat, LLCInventor: Alexander Shulgin
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Patent number: 8471019Abstract: A semiconducting layer comprising a non-polymeric quinoid heteroacene compound of the formula (I) wherein X stands for O, S or NR, each of R, R1, R2, R3, R4, R5, R6, R7, R8 being independently selected from hydrogen and an organic residue, or 2 or more thereof together forming one or more annealed rings, which may be substituted or unsubstituted, carbocyclic or helerocyclic, aromatic, quinoid or aliphatic, may be used e.g. for the manufacture of a diode, an organic field effect transistor, an organic thin film transistor, or a device containing a diode and/or an organic field effect transistor and/or organic thin film transistor.Type: GrantFiled: April 4, 2007Date of Patent: June 25, 2013Assignee: BASF SEInventors: Ulrich Berens, Arno Stassen, Beat Schmidhalter, Wolfgang Kalb, Frank Bienewald
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Patent number: 8404740Abstract: Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the ?-opioid receptor.Type: GrantFiled: August 21, 2009Date of Patent: March 26, 2013Assignee: Gruenenthal GmbHInventors: Stefan Schunk, Saskia Zemolka, Derek Saunders, Michael Gruss, Heinz Graubaum
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Patent number: 8383840Abstract: The present invention provides a method for extracting fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients from complexes of humic substances. The fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients extracts are safe for human and animal consumption and for application to plant foliage. As a result of the extraction method, the fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients extracts further comprise calcium and may comprise magnesium.Type: GrantFiled: October 15, 2010Date of Patent: February 26, 2013Inventor: Geoff McMahon
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Publication number: 20120277332Abstract: One embodiment includes methods of adding two sulfonic acid groups to molecules having at least two cyclic groups.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLCInventors: Thomas J. Chapaton, Tenneille Weston Capehart, Gail Capehart, Armand Soldera, Claude Spino, Riadh Zriba
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Patent number: 8207353Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.Type: GrantFiled: February 17, 2010Date of Patent: June 26, 2012Assignee: Intezyne Technologies, Inc.Inventors: Kevin N. Sill, Habib Skaff, Kurt Breitenkamp
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Patent number: 8124651Abstract: Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.Type: GrantFiled: September 15, 2006Date of Patent: February 28, 2012Assignees: The University of Pittsburgh Office of Technology Transfer, Arizona Board of RegentsInventors: Garth Powis, Peter Wipf
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Patent number: 8084490Abstract: The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.Type: GrantFiled: June 16, 2005Date of Patent: December 27, 2011Assignee: Janssen Pharmaceutica N.V.Inventors: David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
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Publication number: 20110288314Abstract: The present invention relates to a pharmaceutical composition and health functional food having anti-HIV-1 inhibitory activity containing phloroglucinol derivative, 6,6?-bieckol as an effective ingredient, EC extract and its phloroglucinol derivative, 6,6?-bieckol according to the present invention does not show cytotoxic effect compared to other tannin, and have effects to inhibit the HIV-1 induced syncytia formation and the p24 antigen production as well as the HIV-1 reverse transcriptase activity.Type: ApplicationFiled: December 9, 2008Publication date: November 24, 2011Inventors: Moon-Moo Kim, Se-Kwon Kim, Sang-Hoon Lee
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Patent number: 8012606Abstract: Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and simple in structure and also disclosed is a heterocyclic compound useful for the said device. Specifically, the heterocyclic compound is represented by the following general formula (I) and the organic EL device comprises an organic layer containing the said heterocyclic compound. In general formula (I), X1 and X2 respectively denote O, S, or N—R, R denotes a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, Ar1, Ar2, Ar3, and Ar4 respectively denote a substituted or unsubstituted aryl group, Ar1, Ar2, and the nitrogen atom bonded thereto or Ar3, Ar4, and the nitrogen atom bonded thereto may form a nitrogen-containing hetero ring, and m and n respectively denote an integer of 1 or 2.Type: GrantFiled: July 27, 2006Date of Patent: September 6, 2011Assignee: Nippon Steel Chemical Co., Ltd.Inventors: Takahiro Kai, Toshihiro Yamamoto, Masaki Komori, Masanori Hotta, Yuichi Sawada
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Publication number: 20110130575Abstract: A clay comprising a 2:1 aluminosilicate clay having negative charge sites, the 2:1 aluminosilicate clay containing subnano-sized zero valent iron (ZVI) particles distributed on clay surfaces is provided. In one embodiment, at least some or all of the particles have a cross-section of five (5) angstroms or less. Methods of synthesizing and the novel clays and the clay-templated subnano-scale ZVI particles themselves are also described. Such novel products are useful in a variety of remediation applications, including for reduction and dechlorination reactions.Type: ApplicationFiled: October 29, 2010Publication date: June 2, 2011Inventors: Hui Li, Cheng Gu, Stephen A. Boyd
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Publication number: 20110044902Abstract: Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease expression of Foxp3.Type: ApplicationFiled: November 10, 2008Publication date: February 24, 2011Inventors: Howard Weiner, Francisco J. Quintana
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Patent number: 7893277Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.Type: GrantFiled: May 29, 2009Date of Patent: February 22, 2011Assignee: Intezyne Technologies, Inc.Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
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Publication number: 20100283040Abstract: This invention is directed to selenophene compounds, selenophene-based polymers (polyselenophene), processes for the preparation of the same and uses thereof. The polyselenophenes of this invention have high conductivity and can be used as electrodes in various devices such as in electrochromic devices, batteries, solar cells, optical amplifiers, organic light emitting diodes, and the like.Type: ApplicationFiled: September 10, 2008Publication date: November 11, 2010Inventors: Michael Bendikov, Asit Patra, Yair-Haim Wijsboom, Mao Li, Yana Sheynin, Natalia Zamoshchik, Sanjio S. Zade
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Patent number: 7825266Abstract: The present invention provides a method for extracting fulvic acid from complexes of humic substances. The fulvic acid extract is safe for human and animal consumption and for application to plant foliage. As a result of the extraction method, the fulvic acid extract further comprises calcium and may comprise magnesium.Type: GrantFiled: June 15, 2005Date of Patent: November 2, 2010Inventor: Geoff McMahon
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Patent number: 7763742Abstract: A novel compound 4H-indeno[1,2-D]-1,3-dioxole, 3a,3b,5,6,7,8a-hexahydro-2,2,3a,3b,7,7-hexamethyl 1 is disclosed as well as the use of the compound as a fragrance chemical. The fragrance compound is suitable for use in creating fragrances, and scents in items such as perfumes, colognes and personal care products.Type: GrantFiled: August 15, 2006Date of Patent: July 27, 2010Assignee: International Flavors & Fragrances Inc.Inventors: Anthony T. Levorse, Jr., Brett D. Newirth, Manfred Pawlak
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Publication number: 20100184847Abstract: The present invention relates to compositions for skin protection and improvement that contain dibenzo-p-dioxine derivatives as effective components. Since the compositions for skin protection and improvement that contain the dibenzo-p-dioxine derivative according to the present invention have excellent functions such as moisturizing and/or wrinkle prevention which are useful in prevention and improvement of various skin diseases, they can be extensively used as cosmetic ingredients or pharmaceutical agents for prevention and improvement of skin diseases.Type: ApplicationFiled: July 30, 2008Publication date: July 22, 2010Applicant: LIVECHEM, INC.Inventors: Hyeon-Cheol Shin, Hye-Jeong Hwang
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Patent number: 7705040Abstract: This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.Type: GrantFiled: October 7, 2005Date of Patent: April 27, 2010Assignee: The University of Hong KongInventors: Dan Yang, Hua-Li Wang, Zhen-Ning Sun, Jian-Gang Shen
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Patent number: 7642362Abstract: Compounds represented by the general formula (1) wherein R1 and R3 are each independently hydrogen or a carboxyl group and R2 and R4 are each independently hydrogen or a hydroxyl group, or pharmaceutically acceptable salts thereof, which exhibit semaphorin-inhibitory activity and are useful as preventives or remedies for neuropathic and neurodegenerative diseases are provided.Type: GrantFiled: January 22, 2003Date of Patent: January 5, 2010Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Kazuo Kumagai, Nobuo Hosotani
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Patent number: 7605277Abstract: This invention relates to a highly reliable material for an organic electroluminescent element exhibiting high luminance, high luminous efficiency, little deterioration in emission, and suitability for use and storage at high temperatures and to an organic electroluminescent element using said material. The material is a diaminodibenzodioxin derivative represented by general formula (1) wherein Ar1, Ar2, Ar3, and Ar4 are substituted or unsubstituted aryl groups and Ar1, Ar2, and the nitrogen atom bonded thereto or Ar3, Ar4, and the nitrogen atom bonded thereto may form a nitrogen-containing heterocyclic ring; and this diaminodibenzodioxin derivative may be incorporated in the light-emitting layer, the hole-transporting layer, or the hole-injecting layer of an organic electroluminescent element.Type: GrantFiled: January 27, 2005Date of Patent: October 20, 2009Assignee: Nippon Steel Chemical Co., Ltd.Inventors: Takahiro Kai, Hirokatsu Sekiya, Hiroshi Miyazaki, Shigetaka Ishikawa
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Publication number: 20090153031Abstract: Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and simple in structure and also disclosed is a heterocyclic compound useful for the said device. Specifically, the heterocyclic compound is represented by the following general formula (I) and the organic EL device comprises an organic layer containing the said heterocyclic compound. In general formula (I), X1 and X2 respectively denote O, S, or N—R, R denotes a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, Ar1, Ar2, Ar3, and Ar4 respectively denote a substituted or unsubstituted aryl group, Ar1, Ar2, and the nitrogen atom bonded thereto or Ar3, Ar4, and the nitrogen atom bonded thereto may form a nitrogen-containing hetero ring, and m and n respectively denote an integer of 1 or 2.Type: ApplicationFiled: July 27, 2006Publication date: June 18, 2009Applicant: Nippon Steel Chemical Co., LtdInventors: Takahiro Kai, Toshihiro Yamamoto, Masaki Komori, Masanori Hotta, Yuichi Sawada
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Patent number: 7419986Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.Type: GrantFiled: August 31, 2006Date of Patent: September 2, 2008Assignee: WyethInventors: Dahui Zhou, Gary Paul Stack
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Patent number: 7335666Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.Type: GrantFiled: August 31, 2006Date of Patent: February 26, 2008Assignee: WyethInventors: Dahui Zhou, Gary Paul Stack
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Publication number: 20080038838Abstract: A principal object of the present invention is to provide low-cost techniques for readily detecting or quantifying dioxins using substances which are inexpensive and can be easily produced, and extracting dioxins using such substances. Dioxin binding peptides of the present invention are highly selective to dioxins, and are therefore capable of detecting or quantifying dioxins in test samples containing impurities. Dioxin binding peptides of the present invention are also capable of selectively extracting dioxins from impurity-containing test samples, and are therefore useful in simple pretreatment for quantifying and analyzing dioxins.Type: ApplicationFiled: October 1, 2004Publication date: February 14, 2008Applicants: Towa Kagaku Co., Ltd., National Institute of Advanced Industrial Science and TechnologyInventors: Chikashi Nakamura, Jun Miyake, Ikuo Obataya, Noriyuki Nakamura, Katsuhisa Shirai, Yasuhiro Inuyama
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Patent number: 7329637Abstract: The present invention is directed to a novel dioxin compound and the use of the novel compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products.Type: GrantFiled: December 23, 2004Date of Patent: February 12, 2008Assignee: International Flavors & Fragrances Inc.Inventors: Anthony T. Levorse, Jr., Brett D. Newirth, Manfred Pawlak
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Patent number: 7288543Abstract: A compound of the formula (I) (I) wherein the variables X1 to X6, Ra, Rb, R1 to R7 including R3?, E, p, j, y, z, A, B and C are as described or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosedType: GrantFiled: March 8, 2005Date of Patent: October 30, 2007Assignee: Eli Lilly and CompanyInventors: Howard Barff Broughton, Nuria Diaz Buezo, Charles Howard Mitch, Concepcion Pedregal-Tercero
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Patent number: 7208142Abstract: Novel indanylidene compounds can be used as UV-A filters in cosmetic compositions for protecting skin and hair and for technical applications.Type: GrantFiled: November 8, 2001Date of Patent: April 24, 2007Assignee: Symrise GmbH & Co. KGInventors: Oskar Koch, Erich Dilk, Roland Langner, William Johncock
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Patent number: 7135479Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.Type: GrantFiled: September 10, 2003Date of Patent: November 14, 2006Assignee: WyethInventors: Dahui Zhou, Gary Paul Stack
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Patent number: 7122513Abstract: A novel compound 4H-indeno[1,2-D]-1,3-dioxole,3a,3b,5,6,7,8a-hexahydro-2,2,3a,3b,7,7-hexamethyl 1 is dislosed as well as the use of the compound as a fragrance chemical. The fragrance compound is suitable for use in creating fragrances, and scents in items such as perfumes, colognes and personal care products.Type: GrantFiled: December 9, 2004Date of Patent: October 17, 2006Assignee: International Flavor & Fragrance Inc.Inventors: Anthony T. Levorse, Jr., Brett D. Newirth, Manfred Pawlak
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Patent number: 7071359Abstract: A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below R4 represents, hydrogen atoms and acyl groups, W represents single bonds and alkylenes, m represents 0 or 1, R5 and R6 represent hydrogen atoms, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, aromatic hydrocarbon groups and heterocyclic groups, and R7 represents hydrogen atoms, acyl groups and alkoxycarbonyl groups. A2 represents, single bonds, —O—, —NR3—, and —S(?O)n—, A1 and A3 represent single bonds, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, heterocyclic groups and phenylene groups, and A4 represents single bonds, carbonyl groups and aliphatic hydrocarbon groups. R1 and R2 represent hydrogen atoms, alkyl groups, cycloalkyl groups, phenyl groups and heterocyclic groups. The previously mentioned functional groups may be substituted.Type: GrantFiled: August 7, 2000Date of Patent: July 4, 2006Assignee: Teijin LimitedInventors: Satoshi Sugiura, Takaharu Tsutsumi, Yorimasa Suwa, Takami Arai, Katsutoshi Sakurai, Noboru Yoshioka, Akira Tanokura, Jun Suzuki
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Patent number: 6784292Abstract: The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1).Type: GrantFiled: August 21, 2003Date of Patent: August 31, 2004Assignee: Schering AGInventors: Eric Winter, Matthias Schneider, Ulf Tilstam
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Patent number: 6720431Abstract: Sample processing methods that utilize a graphitised carbon matrix are useful for determining the relative amounts polyhalogenated biphenyls (PHBs), polyhalogenated dibenzofurans (PHDFs), and polyhalogenated dibenzo-p-dioxins (PHDDs) in a mixture of polyhalogenated diaromatic hydrocarbons (PHDHs). The methods are particularly useful when used in conjunction with cell-based assays for determining the toxicity of PHDH compounds.Type: GrantFiled: June 1, 2001Date of Patent: April 13, 2004Assignee: Xenobiotic Detection Systems International, Inc.Inventors: Michael D. Chu, George C. Clark
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Patent number: 6696577Abstract: A method of preparing organic acids (fulvic, humic, and ulmic) for use as an electrolyte for producing high ionizations of precious metals (such as silver) which entails leaching out the organic acid from its source, stabilizing the organic acid first with ascorbic acid followed by sodium benzoate, removing cations, and using the organic acid as an electrolyte. A precious metal (such as silver) is used as a sacrificial electrode in this electrolyte. A non-sacrificial electrode could either be the same precious metal or an inert non-precious metal (titanium or graphite carbons). If the same material is used for the non-sacrificial electrode as for the sacrificial electrode, the size of each electrode may be about the same. If different material is used for the non-sacrificial electrode, its size should be larger that of the sacrificial electrode. Current at about 2 or more volts is applied to the electrodes and the ionization process begins yielding high concentrations of ionized precious metals.Type: GrantFiled: September 24, 2002Date of Patent: February 24, 2004Assignee: The Chemins Company, Inc.Inventor: Kenneth D. Westwood
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Publication number: 20030229073Abstract: The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond; Y=O, (CH2)m, S, SO, SO2, NH, NR8; Z=NH, O, NR8, S, SO, SO2. The remaining substituents are described in the specification.Type: ApplicationFiled: July 5, 2002Publication date: December 11, 2003Inventors: Richard John Booth, Vara Prasad Venkata Nagendra Josyula, Annette Lynn Meyer, Bruce Allan Steinbaugh
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Patent number: 6635437Abstract: Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing heterocyclic ring system bearing an exocyclic carbon—carbon double bond. The double bond is further substituted at the distal carbon with a phosphate group and an oxygen or sulfur atom-containing group. Novel compositions further comprising a cationic aromatic compound (CAC) in addition to the heterocyclic phosphate compound are provided. The addition of the CAC in the composition greatly increases the production of chemiluminescence and provides improved detection sensitivity. Compositions further comprising an anionic surfactant and a non-ionic surfactant provide additional improvements in detection sensitivity.Type: GrantFiled: January 22, 2002Date of Patent: October 21, 2003Assignee: Lumigen, Inc.Inventors: Hashem Akhavan-Tafti, Zahra Arghavani, Renuka DeSilva
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Publication number: 20030176670Abstract: Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.Type: ApplicationFiled: December 27, 2002Publication date: September 18, 2003Inventors: John H. Griffin, John L. Pace
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Publication number: 20030149093Abstract: The present invention of compounds of formula (I) 1Type: ApplicationFiled: September 5, 2002Publication date: August 7, 2003Inventors: Piet Tom Bert Paul Wigerinck, Wim Gaston Verschueren, Marc Francis Josephine Schroven, Marcel Frans Leopold De Bruyn
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Patent number: 6566521Abstract: Bidentate phosphine ligands of the formula wherein the substituents are as defined in the specification and a process for preparing linear aldehydes by hydroformylating internal olefins using such phosphine ligands.Type: GrantFiled: November 13, 2001Date of Patent: May 20, 2003Assignee: Celanese GmbHInventors: Holger Geissler, Petrus W. N. M. van Leeuwen, Paul C. J. Kamer, Lars A. van der Veen
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Publication number: 20030069190Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.Type: ApplicationFiled: July 3, 2002Publication date: April 10, 2003Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff