Tricyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/359)
  • Patent number: 10522761
    Abstract: Provided are a compound for an organic optoelectronic device represented by Chemical Formula 1, an organic light emitting diode including the same, and a display device including the organic light emitting diode. The structure of Chemical Formula 1 is shown in the specification. The compound for an organic optoelectronic device provides an organic light emitting diode having life-span characteristics due to excellent electrochemical and thermal stability, and having high luminous efficiency at a low driving voltage.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: December 31, 2019
    Assignee: SAMSUNG SDI CO., LTD.
    Inventors: Dong-Wan Ryu, Eui-Su Kang, Han-Ill Lee, Sung-Hyun Jung, Young-Kyoung Jo, Mi-Young Chae, Dal-Ho Huh, Jin-Seok Hong
  • Patent number: 9492367
    Abstract: The present invention relates to a mixture comprising or consisting of a) 2,2-Dimethyl-3-(3-methylphenyl)-propanol (Majantol) b) 4,4a,5,9b-Tetrahydro-2,4-dimethylindenol[1,2-d]-m-dioxin (Magnolan) and optionally, one, two, three or all of the compounds selected from the group consisting of: c) 2-Isobutyl-4-methyltetrahydro-2H-pyran-4-ol (Florosa) d) Citronellyloxyacetaldehyde (Mugenal) e) 4-n-decylpyridine (Symmarine) f) 4-(4-methyl-3-penten-1-yl)-3-cyclohexene carboxaldehyde (Vertomugal), to a fragrance composition containing an organoleptically effective amount of said mixture and to a perfumed product containing said mixture or said fragrance composition and to a method of imparting an odor to a product or enhancing an odor of a product by adding to the product or incorporating into the product an organoleptically effective amount of a mixture or a fragrance composition according to the invention.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: November 15, 2016
    Assignee: Symrise AG
    Inventors: Wilhelm Wiedmann, Marcus Betzer, Susanne Borchert, Stefan Lambrecht
  • Publication number: 20150111889
    Abstract: The present invention relates to compounds of the formula (I), wherein the residues A, R1 to R5, Z1 and Z2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds for use in the treatment of diverse disorders, for example cardiovascular disorders like thromboembolic diseases or restenoses. The compounds of the invention are effective antagonists of the platelet LPA receptor LPAR5 (GPR92) and can in general be applied in conditions in which an undesired activation of the platelet LPA receptor LPAR5, the mast cell LPA receptor LPAR5 or the microglia cell LPA receptor LPAR5 is present or for the cure or prevention of which an inhibition of the platelet, mast cell or microglia cell LPA receptor LPAR5 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: May 16, 2013
    Publication date: April 23, 2015
    Applicant: SANOFI
    Inventors: Marc Nazare, Detlef Kozian, Martin Bossart, Werngard Czechtizky, Andreas Evers
  • Patent number: 8980586
    Abstract: An object of the present invention is to provide a novel compound useful as an antifungal substance and a method for producing the compound.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: March 17, 2015
    Assignees: The Ritsumeikan Trust, National University Corporation Shizuoka University
    Inventors: Nobutaka Imamura, Kazuya Nakagawa, Shinji Tokuyama
  • Publication number: 20140309438
    Abstract: An object of the present invention is to provide a novel compound useful as an antifungal substance and a method for producing the compound.
    Type: Application
    Filed: October 22, 2012
    Publication date: October 16, 2014
    Applicants: THE RITSUMEIKAN TRUST, NATIONAL UNIVERSITY CORPORATION SHIZUOKA UNIVERSITY
    Inventors: Nobutaka Imamura, Kazuya Nakagawa, Shinji Tokuyama
  • Patent number: 8853263
    Abstract: The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: October 7, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Virginia L. Smith-Swintosky, David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
  • Patent number: 8658706
    Abstract: One embodiment includes methods of adding two sulfonic acid groups to molecules having at least two cyclic groups.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: February 25, 2014
    Assignee: GM Global Technology Operations LLC
    Inventors: Thomas J. Chapaton, Tenneille Weston Capehart, Armand Soldera, Claude Spino, Riadh Zriba, Gail Capehart
  • Publication number: 20140039204
    Abstract: The effects on human hair growth of 7?-phloroeckol (1-(3?,5?-dihydroxyphenoxy)-7-(2?,4?,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin) isolated from E. cava (Ecklonia cava) have been studied in cell systems. The cell-proliferation and anti-apoptotic effects on human human hair follicle dermal papilla cells (HFDPC) and human keratinocytes (human epidermal keratinocytes: HaCaT) were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot. The 7?-phloroeckol significantly increased HFDPC and HaCaT proliferation. With HFDPC and HaCaT, the amount of PI3K and phosphorylated AKT protein expression increased in a way which was dependent on the extent of 7?-phloroeckol treatment. Also, the levels of MEK½, phosphorylated ERK and c-Fos proteins, which are associated with cell proliferation, increased in a way which was dependent on the extent of 7?-phloroeckol treatment.
    Type: Application
    Filed: March 24, 2011
    Publication date: February 6, 2014
    Applicant: PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
    Inventors: Se-Kwon Kim, Soon-Sun Bak
  • Patent number: 8641797
    Abstract: The method of the present disclosure includes providing an organic compost material, combining the organic compost material with a crop to be grown, heating the organic compost material, combining the organic compost material with water, and extracting an aqueous liquid comprising humic acid and fulvic acid. The organic compost material may include straw and manure and the straw and manure may be subjected to several days and/or weeks of aerobic composting. The crop may include a variety of plants, trees, vegetables, fruits and fungi. In one embodiment, the crop may include mushroom spores, mycelia, or mushrooms.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: February 4, 2014
    Assignee: Black Dirt Organics Patent Management
    Inventors: Don Calvin Van Dyke, Asa Staples Nielson, Bruce Sutton, Dan Davies, Loyal B. Adams
  • Publication number: 20130338217
    Abstract: There is provided an antibiotic composition including Eisenia bicyclis-derived phlorotannin compound, in which the antibiotic composition includes a phlorotannin compound selected from 7-phloroeckol, fucofuroeckol-A, and dioxinodehydroeckol, or mixture thereof, which are derived from Eisenia bicyclis, as an effective component. The compounds described above exhibit an antibiotic activity against an antibiotic-resistant bacterium. In addition, the compound described above can exhibit a synergetic effect by using in combination with ?-lactam-based antibiotic composition by recovering an antibiotic activity of ?-lactam-based antibiotic, such as ampicillin, penicillin, and oxacillin against MRSA.
    Type: Application
    Filed: October 30, 2012
    Publication date: December 19, 2013
    Applicant: Pukyong National University Industry-University Cooperation Foundation
    Inventors: Se-Kwon KIM, Young-Mog Kim, Myung-Suk Lee, Sung-Hwan Eom
  • Publication number: 20130336993
    Abstract: Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease expression of Foxp3.
    Type: Application
    Filed: January 18, 2013
    Publication date: December 19, 2013
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Howard Weiner, Francisco J. Quintana
  • Patent number: 8580979
    Abstract: Humic Acid is extracted and then can be used to treat flue gas and fly ash from the combustion of coal or municipal waste. The resulting product may be used as a soil ameliorant.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: November 12, 2013
    Assignee: Organocat, LLC
    Inventor: Alexander Shulgin
  • Patent number: 8471019
    Abstract: A semiconducting layer comprising a non-polymeric quinoid heteroacene compound of the formula (I) wherein X stands for O, S or NR, each of R, R1, R2, R3, R4, R5, R6, R7, R8 being independently selected from hydrogen and an organic residue, or 2 or more thereof together forming one or more annealed rings, which may be substituted or unsubstituted, carbocyclic or helerocyclic, aromatic, quinoid or aliphatic, may be used e.g. for the manufacture of a diode, an organic field effect transistor, an organic thin film transistor, or a device containing a diode and/or an organic field effect transistor and/or organic thin film transistor.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: June 25, 2013
    Assignee: BASF SE
    Inventors: Ulrich Berens, Arno Stassen, Beat Schmidhalter, Wolfgang Kalb, Frank Bienewald
  • Patent number: 8404740
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the ?-opioid receptor.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: March 26, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Schunk, Saskia Zemolka, Derek Saunders, Michael Gruss, Heinz Graubaum
  • Patent number: 8383840
    Abstract: The present invention provides a method for extracting fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients from complexes of humic substances. The fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients extracts are safe for human and animal consumption and for application to plant foliage. As a result of the extraction method, the fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients extracts further comprise calcium and may comprise magnesium.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: February 26, 2013
    Inventor: Geoff McMahon
  • Publication number: 20120277332
    Abstract: One embodiment includes methods of adding two sulfonic acid groups to molecules having at least two cyclic groups.
    Type: Application
    Filed: April 29, 2011
    Publication date: November 1, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Thomas J. Chapaton, Tenneille Weston Capehart, Gail Capehart, Armand Soldera, Claude Spino, Riadh Zriba
  • Patent number: 8207353
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: June 26, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin N. Sill, Habib Skaff, Kurt Breitenkamp
  • Patent number: 8124651
    Abstract: Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: February 28, 2012
    Assignees: The University of Pittsburgh Office of Technology Transfer, Arizona Board of Regents
    Inventors: Garth Powis, Peter Wipf
  • Patent number: 8084490
    Abstract: The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: December 27, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
  • Publication number: 20110288314
    Abstract: The present invention relates to a pharmaceutical composition and health functional food having anti-HIV-1 inhibitory activity containing phloroglucinol derivative, 6,6?-bieckol as an effective ingredient, EC extract and its phloroglucinol derivative, 6,6?-bieckol according to the present invention does not show cytotoxic effect compared to other tannin, and have effects to inhibit the HIV-1 induced syncytia formation and the p24 antigen production as well as the HIV-1 reverse transcriptase activity.
    Type: Application
    Filed: December 9, 2008
    Publication date: November 24, 2011
    Inventors: Moon-Moo Kim, Se-Kwon Kim, Sang-Hoon Lee
  • Patent number: 8012606
    Abstract: Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and simple in structure and also disclosed is a heterocyclic compound useful for the said device. Specifically, the heterocyclic compound is represented by the following general formula (I) and the organic EL device comprises an organic layer containing the said heterocyclic compound. In general formula (I), X1 and X2 respectively denote O, S, or N—R, R denotes a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, Ar1, Ar2, Ar3, and Ar4 respectively denote a substituted or unsubstituted aryl group, Ar1, Ar2, and the nitrogen atom bonded thereto or Ar3, Ar4, and the nitrogen atom bonded thereto may form a nitrogen-containing hetero ring, and m and n respectively denote an integer of 1 or 2.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: September 6, 2011
    Assignee: Nippon Steel Chemical Co., Ltd.
    Inventors: Takahiro Kai, Toshihiro Yamamoto, Masaki Komori, Masanori Hotta, Yuichi Sawada
  • Publication number: 20110130575
    Abstract: A clay comprising a 2:1 aluminosilicate clay having negative charge sites, the 2:1 aluminosilicate clay containing subnano-sized zero valent iron (ZVI) particles distributed on clay surfaces is provided. In one embodiment, at least some or all of the particles have a cross-section of five (5) angstroms or less. Methods of synthesizing and the novel clays and the clay-templated subnano-scale ZVI particles themselves are also described. Such novel products are useful in a variety of remediation applications, including for reduction and dechlorination reactions.
    Type: Application
    Filed: October 29, 2010
    Publication date: June 2, 2011
    Inventors: Hui Li, Cheng Gu, Stephen A. Boyd
  • Publication number: 20110044902
    Abstract: Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease expression of Foxp3.
    Type: Application
    Filed: November 10, 2008
    Publication date: February 24, 2011
    Inventors: Howard Weiner, Francisco J. Quintana
  • Patent number: 7893277
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: February 22, 2011
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
  • Publication number: 20100283040
    Abstract: This invention is directed to selenophene compounds, selenophene-based polymers (polyselenophene), processes for the preparation of the same and uses thereof. The polyselenophenes of this invention have high conductivity and can be used as electrodes in various devices such as in electrochromic devices, batteries, solar cells, optical amplifiers, organic light emitting diodes, and the like.
    Type: Application
    Filed: September 10, 2008
    Publication date: November 11, 2010
    Inventors: Michael Bendikov, Asit Patra, Yair-Haim Wijsboom, Mao Li, Yana Sheynin, Natalia Zamoshchik, Sanjio S. Zade
  • Patent number: 7825266
    Abstract: The present invention provides a method for extracting fulvic acid from complexes of humic substances. The fulvic acid extract is safe for human and animal consumption and for application to plant foliage. As a result of the extraction method, the fulvic acid extract further comprises calcium and may comprise magnesium.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: November 2, 2010
    Inventor: Geoff McMahon
  • Patent number: 7763742
    Abstract: A novel compound 4H-indeno[1,2-D]-1,3-dioxole, 3a,3b,5,6,7,8a-hexahydro-2,2,3a,3b,7,7-hexamethyl 1 is disclosed as well as the use of the compound as a fragrance chemical. The fragrance compound is suitable for use in creating fragrances, and scents in items such as perfumes, colognes and personal care products.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: July 27, 2010
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Anthony T. Levorse, Jr., Brett D. Newirth, Manfred Pawlak
  • Publication number: 20100184847
    Abstract: The present invention relates to compositions for skin protection and improvement that contain dibenzo-p-dioxine derivatives as effective components. Since the compositions for skin protection and improvement that contain the dibenzo-p-dioxine derivative according to the present invention have excellent functions such as moisturizing and/or wrinkle prevention which are useful in prevention and improvement of various skin diseases, they can be extensively used as cosmetic ingredients or pharmaceutical agents for prevention and improvement of skin diseases.
    Type: Application
    Filed: July 30, 2008
    Publication date: July 22, 2010
    Applicant: LIVECHEM, INC.
    Inventors: Hyeon-Cheol Shin, Hye-Jeong Hwang
  • Patent number: 7705040
    Abstract: This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: April 27, 2010
    Assignee: The University of Hong Kong
    Inventors: Dan Yang, Hua-Li Wang, Zhen-Ning Sun, Jian-Gang Shen
  • Patent number: 7642362
    Abstract: Compounds represented by the general formula (1) wherein R1 and R3 are each independently hydrogen or a carboxyl group and R2 and R4 are each independently hydrogen or a hydroxyl group, or pharmaceutically acceptable salts thereof, which exhibit semaphorin-inhibitory activity and are useful as preventives or remedies for neuropathic and neurodegenerative diseases are provided.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: January 5, 2010
    Assignee: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Kazuo Kumagai, Nobuo Hosotani
  • Patent number: 7605277
    Abstract: This invention relates to a highly reliable material for an organic electroluminescent element exhibiting high luminance, high luminous efficiency, little deterioration in emission, and suitability for use and storage at high temperatures and to an organic electroluminescent element using said material. The material is a diaminodibenzodioxin derivative represented by general formula (1) wherein Ar1, Ar2, Ar3, and Ar4 are substituted or unsubstituted aryl groups and Ar1, Ar2, and the nitrogen atom bonded thereto or Ar3, Ar4, and the nitrogen atom bonded thereto may form a nitrogen-containing heterocyclic ring; and this diaminodibenzodioxin derivative may be incorporated in the light-emitting layer, the hole-transporting layer, or the hole-injecting layer of an organic electroluminescent element.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: October 20, 2009
    Assignee: Nippon Steel Chemical Co., Ltd.
    Inventors: Takahiro Kai, Hirokatsu Sekiya, Hiroshi Miyazaki, Shigetaka Ishikawa
  • Publication number: 20090153031
    Abstract: Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and simple in structure and also disclosed is a heterocyclic compound useful for the said device. Specifically, the heterocyclic compound is represented by the following general formula (I) and the organic EL device comprises an organic layer containing the said heterocyclic compound. In general formula (I), X1 and X2 respectively denote O, S, or N—R, R denotes a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, Ar1, Ar2, Ar3, and Ar4 respectively denote a substituted or unsubstituted aryl group, Ar1, Ar2, and the nitrogen atom bonded thereto or Ar3, Ar4, and the nitrogen atom bonded thereto may form a nitrogen-containing hetero ring, and m and n respectively denote an integer of 1 or 2.
    Type: Application
    Filed: July 27, 2006
    Publication date: June 18, 2009
    Applicant: Nippon Steel Chemical Co., Ltd
    Inventors: Takahiro Kai, Toshihiro Yamamoto, Masaki Komori, Masanori Hotta, Yuichi Sawada
  • Patent number: 7419986
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: September 2, 2008
    Assignee: Wyeth
    Inventors: Dahui Zhou, Gary Paul Stack
  • Patent number: 7335666
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: February 26, 2008
    Assignee: Wyeth
    Inventors: Dahui Zhou, Gary Paul Stack
  • Publication number: 20080038838
    Abstract: A principal object of the present invention is to provide low-cost techniques for readily detecting or quantifying dioxins using substances which are inexpensive and can be easily produced, and extracting dioxins using such substances. Dioxin binding peptides of the present invention are highly selective to dioxins, and are therefore capable of detecting or quantifying dioxins in test samples containing impurities. Dioxin binding peptides of the present invention are also capable of selectively extracting dioxins from impurity-containing test samples, and are therefore useful in simple pretreatment for quantifying and analyzing dioxins.
    Type: Application
    Filed: October 1, 2004
    Publication date: February 14, 2008
    Applicants: Towa Kagaku Co., Ltd., National Institute of Advanced Industrial Science and Technology
    Inventors: Chikashi Nakamura, Jun Miyake, Ikuo Obataya, Noriyuki Nakamura, Katsuhisa Shirai, Yasuhiro Inuyama
  • Patent number: 7329637
    Abstract: The present invention is directed to a novel dioxin compound and the use of the novel compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: February 12, 2008
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Anthony T. Levorse, Jr., Brett D. Newirth, Manfred Pawlak
  • Patent number: 7288543
    Abstract: A compound of the formula (I) (I) wherein the variables X1 to X6, Ra, Rb, R1 to R7 including R3?, E, p, j, y, z, A, B and C are as described or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: October 30, 2007
    Assignee: Eli Lilly and Company
    Inventors: Howard Barff Broughton, Nuria Diaz Buezo, Charles Howard Mitch, Concepcion Pedregal-Tercero
  • Patent number: 7208142
    Abstract: Novel indanylidene compounds can be used as UV-A filters in cosmetic compositions for protecting skin and hair and for technical applications.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: April 24, 2007
    Assignee: Symrise GmbH & Co. KG
    Inventors: Oskar Koch, Erich Dilk, Roland Langner, William Johncock
  • Patent number: 7135479
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: November 14, 2006
    Assignee: Wyeth
    Inventors: Dahui Zhou, Gary Paul Stack
  • Patent number: 7122513
    Abstract: A novel compound 4H-indeno[1,2-D]-1,3-dioxole,3a,3b,5,6,7,8a-hexahydro-2,2,3a,3b,7,7-hexamethyl 1 is dislosed as well as the use of the compound as a fragrance chemical. The fragrance compound is suitable for use in creating fragrances, and scents in items such as perfumes, colognes and personal care products.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: October 17, 2006
    Assignee: International Flavor & Fragrance Inc.
    Inventors: Anthony T. Levorse, Jr., Brett D. Newirth, Manfred Pawlak
  • Patent number: 7071359
    Abstract: A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below R4 represents, hydrogen atoms and acyl groups, W represents single bonds and alkylenes, m represents 0 or 1, R5 and R6 represent hydrogen atoms, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, aromatic hydrocarbon groups and heterocyclic groups, and R7 represents hydrogen atoms, acyl groups and alkoxycarbonyl groups. A2 represents, single bonds, —O—, —NR3—, and —S(?O)n—, A1 and A3 represent single bonds, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, heterocyclic groups and phenylene groups, and A4 represents single bonds, carbonyl groups and aliphatic hydrocarbon groups. R1 and R2 represent hydrogen atoms, alkyl groups, cycloalkyl groups, phenyl groups and heterocyclic groups. The previously mentioned functional groups may be substituted.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: July 4, 2006
    Assignee: Teijin Limited
    Inventors: Satoshi Sugiura, Takaharu Tsutsumi, Yorimasa Suwa, Takami Arai, Katsutoshi Sakurai, Noboru Yoshioka, Akira Tanokura, Jun Suzuki
  • Patent number: 6784292
    Abstract: The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1).
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: August 31, 2004
    Assignee: Schering AG
    Inventors: Eric Winter, Matthias Schneider, Ulf Tilstam
  • Patent number: 6720431
    Abstract: Sample processing methods that utilize a graphitised carbon matrix are useful for determining the relative amounts polyhalogenated biphenyls (PHBs), polyhalogenated dibenzofurans (PHDFs), and polyhalogenated dibenzo-p-dioxins (PHDDs) in a mixture of polyhalogenated diaromatic hydrocarbons (PHDHs). The methods are particularly useful when used in conjunction with cell-based assays for determining the toxicity of PHDH compounds.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: April 13, 2004
    Assignee: Xenobiotic Detection Systems International, Inc.
    Inventors: Michael D. Chu, George C. Clark
  • Patent number: 6696577
    Abstract: A method of preparing organic acids (fulvic, humic, and ulmic) for use as an electrolyte for producing high ionizations of precious metals (such as silver) which entails leaching out the organic acid from its source, stabilizing the organic acid first with ascorbic acid followed by sodium benzoate, removing cations, and using the organic acid as an electrolyte. A precious metal (such as silver) is used as a sacrificial electrode in this electrolyte. A non-sacrificial electrode could either be the same precious metal or an inert non-precious metal (titanium or graphite carbons). If the same material is used for the non-sacrificial electrode as for the sacrificial electrode, the size of each electrode may be about the same. If different material is used for the non-sacrificial electrode, its size should be larger that of the sacrificial electrode. Current at about 2 or more volts is applied to the electrodes and the ionization process begins yielding high concentrations of ionized precious metals.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: February 24, 2004
    Assignee: The Chemins Company, Inc.
    Inventor: Kenneth D. Westwood
  • Publication number: 20030229073
    Abstract: The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond; Y=O, (CH2)m, S, SO, SO2, NH, NR8; Z=NH, O, NR8, S, SO, SO2. The remaining substituents are described in the specification.
    Type: Application
    Filed: July 5, 2002
    Publication date: December 11, 2003
    Inventors: Richard John Booth, Vara Prasad Venkata Nagendra Josyula, Annette Lynn Meyer, Bruce Allan Steinbaugh
  • Patent number: 6635437
    Abstract: Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing heterocyclic ring system bearing an exocyclic carbon—carbon double bond. The double bond is further substituted at the distal carbon with a phosphate group and an oxygen or sulfur atom-containing group. Novel compositions further comprising a cationic aromatic compound (CAC) in addition to the heterocyclic phosphate compound are provided. The addition of the CAC in the composition greatly increases the production of chemiluminescence and provides improved detection sensitivity. Compositions further comprising an anionic surfactant and a non-ionic surfactant provide additional improvements in detection sensitivity.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: October 21, 2003
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Zahra Arghavani, Renuka DeSilva
  • Publication number: 20030176670
    Abstract: Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.
    Type: Application
    Filed: December 27, 2002
    Publication date: September 18, 2003
    Inventors: John H. Griffin, John L. Pace
  • Publication number: 20030149093
    Abstract: The present invention of compounds of formula (I) 1
    Type: Application
    Filed: September 5, 2002
    Publication date: August 7, 2003
    Inventors: Piet Tom Bert Paul Wigerinck, Wim Gaston Verschueren, Marc Francis Josephine Schroven, Marcel Frans Leopold De Bruyn
  • Patent number: 6566521
    Abstract: Bidentate phosphine ligands of the formula wherein the substituents are as defined in the specification and a process for preparing linear aldehydes by hydroformylating internal olefins using such phosphine ligands.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: May 20, 2003
    Assignee: Celanese GmbH
    Inventors: Holger Geissler, Petrus W. N. M. van Leeuwen, Paul C. J. Kamer, Lars A. van der Veen
  • Publication number: 20030069190
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 10, 2003
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff