Halogen Attached Directly Or Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/380)
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Publication number: 20140018414Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: ApplicationFiled: March 14, 2013Publication date: January 16, 2014Inventor: Robert J. Brosnan
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Patent number: 8222435Abstract: The present invention relates to novel acylmethylene-1,3-dioxolanes and acylmethylene-1,4-dioxanes of the general formula (I) in which R1, R2, R3 and n have the meanings given in the description, and also a novel process for their preparation. Acylmethylene-1,3-dioxolanes and acylmethylene-1,4-dioxanes are important intermediates for the preparation of pyrazoles and anthranilamides, which can be used as insecticides.Type: GrantFiled: December 15, 2010Date of Patent: July 17, 2012Assignee: Bayer CropScience AGInventors: Sergii Pazenok, Norbert Lui, Igor Gerus, Olga Balabon
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Patent number: 8211513Abstract: The present invention relates to liquid-crystalline compounds having at least three fluorine-substituted benzene rings, a terminal trifluoromethyl group and at least one —CF2O— bridge. The invention also relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media.Type: GrantFiled: March 22, 2011Date of Patent: July 3, 2012Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Axel Jansen, Helmut Haensel, Philipp Krattiger, Andreas Taugerbeck, Malgorzata Rillich
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Patent number: 7838087Abstract: Known compounds showing negative dielectric anisotropy show negative dielectric anisotropy of relatively large values but are not satisfactory in view of the balance of the physical property as the liquid crystal material such as having low clearing point and showing high viscosity. The present invention intends to provide a liquid crystalline compound showing a negative dielectric anisotropy, as well as having excellent balance for physical property such as having relatively high clearing point, relatively low viscosity, appropriate optical anisotropy, and excellent compatibility with other liquid crystalline compounds. The compound of the invention is a compound represented by Formula (1) or Formula (2).Type: GrantFiled: March 29, 2005Date of Patent: November 23, 2010Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventors: Syuichi Matsui, Yasuyuki Sasada
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Patent number: 7270856Abstract: The invention relates to novel cyclobutane derivatives of the formula (I), in which R1, R2, A, Z, m, n and o have the meaning indicated in claim 1, to the use thereof as components of liquid-crystalline media, and to liquid-crystal and electro-optical display elements which contain the liquid-crystalline media according to the inventionType: GrantFiled: November 5, 2003Date of Patent: September 18, 2007Assignee: Merck Patent GmbHInventors: Andreas Taugerbeck, Michael Heckmeier, Peer Kirsch, Georg Luessem, Eike Poetsch
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Patent number: 6916940Abstract: The invention relates to a process for the preparation of cyclic carboxylic acid orthoester fluorides in which a) at least one bis(alkylthio)carbenium salt is reacted with at least one organic compound containing at least two hydroxyl groups in the presence of at least one base, b) and subsequently, preferably in situ, the resultant thioorthoester is subjected to oxidative fluorodesulfurisation using a fluorinating agent and an oxidant to give the cyclic carboxylic acid orthoester fluoride.Type: GrantFiled: October 1, 2001Date of Patent: July 12, 2005Assignee: Merck Patent GmbHInventors: Peer Kirsch, Andreas Taugerbeck
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Patent number: 6849733Abstract: There are disclosed novel neuropeptide Y ligands having the general formula I Wherein the symbols W, A, D, R1, R2, R3, R4 are further defined in the description. Compounds of formula I are agonists and antagonists of neuropeptide Y, and are therefore useful as regulators.Type: GrantFiled: August 22, 1997Date of Patent: February 1, 2005Assignee: Agouron Pharmaceuticals, Inc.Inventors: Yufeng Hong, Vlad Edward Gregor, Anthony Lai Ling, Eileen Valenzuela Tompkins
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Patent number: 6737124Abstract: Chiral nonracemic, chiral racemic and achiral compounds useful as component of LC compositions which have a silane tail group which is partially fluorinated. The silane tail group comprises a perfluoroalkyl group. The silane tail group of this invention has the formula: where k is 0 or an integer ranging from 1-10; m and n are integers ranging from 1 to about 20; j is 0 or an integer ranging from 1 to 20; Z is —O— or a single bond; R1, R1′, R2 and R2′ are alkyl groups or perfluorinated alkyl groups; and RF is a perfluorinated alkyl group. The invention also provides LC compositions comprising one or more compounds of the invention with partially fluorinated silane tails. The invention also provides optical devices, particularly display devices which contain an aligned layer of an LC composition comprising one or more silane compounds of this invention.Type: GrantFiled: January 3, 2001Date of Patent: May 18, 2004Assignee: Displaytech, Inc.Inventors: Neil Gough, Xin-Hua Chen, William N. Thurmes, Michael Wand
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Patent number: 6649227Abstract: Provided are liquid crystalline compounds having a wide liquid crystal phase temperature range, low viscosity, a large elastic constant ratio K33/K11 and excellent solubility at low temperature, a liquid crystal composition using the same and a liquid crystal display.Type: GrantFiled: July 6, 2001Date of Patent: November 18, 2003Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventors: Takashi Kato, Shuichi Matsui, Hiroyuki Takeuchi, Yasuhiro Kubo, Etsuo Nakagawa
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Publication number: 20020130300Abstract: The invention relates to novel dioxane derivatives of the formula IType: ApplicationFiled: August 6, 2001Publication date: September 19, 2002Applicant: Merck GmbHInventors: Matthias Bremer, Peer Kirsch, Sabine Schoen, Detlef Pauluth, Kazuaki Tarumi, Georg Lussem, Michael Heckmeier, Joachim Krause
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Patent number: 6309561Abstract: Fluorine-containing, chiral liquid crystal compounds comprise (a) a chiral fluorochemical terminal portion comprising (i) at least one chiral center, which can optionally be heteroatom-substituted; (ii) a terminal fluoroalkyl, fluoroether, perfluoroalkyl, or perfluoroether group; and (iii) an alkylene or fluoroalkylene group optionally containing at least one catenary ether oxygen atom; (b) a chiral or achiral terminal portion consisting of a hydrocarbon or hydrocarbon ether group, and, when chiral, comprising at least one chiral center, which can optionally be heteroatom-substituted; and (c) a central core connecting the terminal portions; the alkylene or fluoroalkylene group of the chiral fluorochemical terminal portion having at least 3 in-chain atoms and being located between the chiral center of the chiral fluorochemical terminal portion and the central core. The compounds have smectic mesophases or latent smectic mesophases and are useful, for example, in liquid crystal display devices.Type: GrantFiled: December 24, 1997Date of Patent: October 30, 2001Assignee: 3M Innovative Properties CompanyInventors: Masakazu Hasegawa, Michael P. Keyes, Marc D. Radcliffe, Patricia M. Savu, Daniel C. Snustad, Terence D. Spawn
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Patent number: 6030547Abstract: Fluorine-containing, chiral liquid crystal compounds comprise (a) a chiral fluorochemical terminal portion comprising (i) at least one chiral center, which can optionally be heteroatom-substituted; (ii) a terminal fluoroalkyl, fluoroether, perfluoroalkyl, or perfluoroether group; and (iii) an alkylene or fluoroalkylene group optionally containing at least one caternary ether oxygen atom; (b) a chiral or achiral terminal portion consisting of a hydrocarbon or hydrocarbon ether group, and, when chiral, comprising at least one chiral center, which can optionally be heteroatom-substituted; and (c) a central core connecting the terminal portions; the alkylene or fluoroalkylene group of the chiral fluorochemical terminal portion having at least 3 in-chain atoms and being located between the chiral center of the chiral fluorochemical terminal portion and the central core. The compounds have smectic mesophases or latent smectic mesophases and are useful, for example, in liquid crystal display devices.Type: GrantFiled: December 24, 1997Date of Patent: February 29, 2000Assignee: 3M Innovative Properties CompanyInventors: Masakazu Hasegawa, Michael P. Keyes, Marc D. Radcliffe, Patricia M. Savu, Daniel C. Snustad, Terence D. Spawn
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Patent number: 5972241Abstract: Fluorine-containing, chiral liquid crystal compounds comprise (a) a chiral fluorochemical terminal portion containing at least one methylene group and optionally containing at least one catenary ether oxygen atom; (b) a saturated, chiral or achiral, hydrocarbon terminal portion; and (c) a central core connecting the terminal portions. The compounds have smectic mesophases or latent smectic mesophases and are useful, for example, in liquid crystal display devices.Type: GrantFiled: November 6, 1997Date of Patent: October 26, 1999Assignee: 3M Innovative Properties CompanyInventors: Gilbert C. Johnson, Marc D. Radcliffe, Patricia M. Savu, Daniel C. Snustad, Terence D. Spawn
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Patent number: 5969074Abstract: A reaction of perfluoroolefins with bis(silyl) ethers to produce novel partially fluorinated and perfluorinated copolymers and macrocyclic compounds is disclosed.Type: GrantFiled: May 21, 1993Date of Patent: October 19, 1999Assignee: E. I. du Pont de Nemours and CompanyInventors: William Brown Farnham, Mario Joseph Nappa
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Patent number: 5702637Abstract: Fluorine-containing, chiral liquid crystal compounds comprise (a) a chiral fluorochemical terminal portion containing at least one methylene group and optionally containing at least one catenary ether oxygen atom; (b) a saturated, chiral or achiral, hydrocarbon terminal portion; and (c) a central core connecting the terminal portions. The compounds have smectic mesophases or latent smectic mesophases and are useful, for example, in liquid crystal display devices.Type: GrantFiled: April 19, 1995Date of Patent: December 30, 1997Assignee: Minnesota Mining and Manufacturing CompanyInventors: Gilbert C. Johnson, Marc D. Radcliffe, Patricia M. Savu, Daniel C. Snustad, Terence D. Spawn
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Patent number: 5672767Abstract: A process for the preparation of a perfluoropolyether having a general formula: ##STR1## as defined hereinbefore, which process includes the direct fluorination with elemental fluorine of a polyether having a general formula: ##STR2## as defined hereinbefore, wherein the fluorination is carried out in the presence of a solvent which is an ether having at least one substituent R.sub.F, wherein R.sub.F is a fluorinated hydrocarbon group. The said solvent ether is preferably a fluorinated volatile ether. The said solvent ether preferably has at least two groups R.sub.F which may be the same or different groups. Each group R.sub.F preferably has from two to four carbon atoms and at least two fluorine atoms. The said solvent ether may be an alicyclic ether having from 3 to 5 carbon atoms in its alicyclic ring.Type: GrantFiled: July 5, 1996Date of Patent: September 30, 1997Assignee: BNFL Fluorochemicals Ltd.Inventors: Richard Dickinson Chambers, Andrew Keith Joel
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Patent number: 5552549Abstract: Chlorinated aromatic compounds are dechlorinated in a simple and inexpensive manner by heating them to 300.degree. to 450.degree. C. in a salt melt in the presence of water and/or water vapor and carbon.Type: GrantFiled: September 29, 1994Date of Patent: September 3, 1996Assignee: Bayer AktiengesellschaftInventors: Christian Rasp, Helmut Waldmann, Hans-Joachim Traenckner
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Patent number: 5457215Abstract: A reaction of perfluoroolefins with bis(silyl) ethers to produce novel partially fluorinated and perfluorinated copolymers and macrocyclic compounds is disclosed.Type: GrantFiled: July 5, 1994Date of Patent: October 10, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: William B. Farnham, Mario J. Nappa
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Patent number: 5419851Abstract: The present invention provides a difluoro-derivative compound of the formula R.sup.1 --(A.sup.1 --Y.sup.1).sub.m --A.sup.2 --CF.dbd.CF--C.tbd.C--A.sup.3 --(Y.sup.2 --A.sup.4).sub.n --R.sup.2 (wherein each of A.sup.1 to A.sup.4 is a trans-1,4-cyclohexylene group, a 1,4-cyclohexenylene group or a 1,4-phenylene group, each of m and n is 0 or 1, and each of R.sup.1 and R.sup.2 is a C.sub.1-10 alkyl group, a halogen atom or a cyano group).The compound of the present invention has a low viscosity and is stable against lights, and a high speed response is expected by using it for a liquid crystal composition.Type: GrantFiled: April 20, 1994Date of Patent: May 30, 1995Assignee: Asahi Glass Company Ltd.Inventors: Osamu Yokokoji, Jun Irisawa, Hidemasa Koh
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Patent number: 5399292Abstract: Fluoro-substituted phenyl-cyclohexylacetylenes have the formula: ##STR1## wherein R signifies alkyl, alkoxy, alkenyl or alkenyloxy with 1 or, respectively, 2 to 12 carbon atoms in which one CH.sub.2 group can be replaced by oxygen and/or one or more hydrogen atoms can be replaced by fluorine atoms, with the proviso that two oxygen atoms are not directly adjacent;A.sup.1 represents 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl, trans-1,4-cyclohexylene or trans-1,3-dioxane-2,5-diyl;A.sup.2 signifies trans-1,4-cyclohexylene or 1,4-phenylene which is optionally substituted with fluorine;Z.sup.1 signifies a single covalent bond, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O--, --(CH.sub.2).sub.4 --, --O(CH.sub.2).sub.3 --, --(CH.sub.2).sub.3 O-- or, when ring A.sup.1 represents a saturated ring, also the trans form of --CH.dbd.CH(CH.sub.2).sub.2 -- or --CH.dbd.CHCH.sub.2 O--;Z.sup.2 signifies a single covalent bond, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O--, --(CH.sub.2).sub.Type: GrantFiled: May 2, 1994Date of Patent: March 21, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Richard Buchecker, Martin Schadt
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Patent number: 5399291Abstract: Fluorine-containing, chiral and achiral liquid crystal compounds comprise (a) an aliphatic fluorocarbon terminal portion comprising a perfluorinated or partially-fluorinated alkylene group and a terminal hydrocarbon alkyl group, the groups optionally containing at least one catenary ether oxygen atom; (b) an aliphatic hydrocarbon terminal portion; and (c) a central core connecting the terminal portions. The compounds have smectic mesophases or latent smectic mesophases and are useful, for example, in liquid crystal display devices.Type: GrantFiled: September 30, 1993Date of Patent: March 21, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Eugene P. Janulis, Gilbert C. Johnson, Marc D. Radcliffe, Patricia M. Savu, Daniel C. Snustad, Terence D. Spawn
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Patent number: 5254699Abstract: Provided are novel cyclic perfluoroethers which are thermally and chemical stable fluids. They are prepared by photo decarbonylation of cyclic perfluoroketones.Type: GrantFiled: April 16, 1992Date of Patent: October 19, 1993Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Hiroshi Inomata, Yasuo Tarumi, Noriyuki Koike, Shuzi Suganuma
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Patent number: 5166367Abstract: A compound of the formula: ##STR1## wherein the dotted line represents optional unsaturation; R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, amino, mono- or dialkylamino, alkanamido or sulfonamido or R.sup.1 and R.sup.2 together are methylenedioxy, ethylenedioxy or propylenedioxy; R.sup.3 is hydrogen or alkyl; n is one of the integers 2,3 or 4; X is O or NR.sup.4, in which R.sup.4 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, are antipsychotic agents.Type: GrantFiled: June 21, 1991Date of Patent: November 24, 1992Assignee: American Home Products CorporationInventors: Gary P. Stack, Terrance H. Andree, Noreen T. Scherer
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Patent number: 5164517Abstract: This invention relates to a process for preparing fluoropolyethers and perfluoropolyethers having neutral and/or functional end groups and a lower molecular weight by a selective catalytic cleavage of the corresponding higher molecular weight fluoropolyethers and perfluoropolyethers, characterized in that said cleavage is carried out by operating in the presence of a catalyst system consisting of a combination of silicon dioxide with at least an oxide, a fluoride or an oxyfluoride of a metal selected from Al, Ti, V, Cr, Co. Fe, Ni, Mo, Zn, Cu, Cd, Mn, Sb, Sn, Zr, Sc, Y, La and homologs thereof, Pb, Mg, W.Type: GrantFiled: January 29, 1991Date of Patent: November 17, 1992Assignee: Ausimont S.p.A.Inventors: Giuseppe Marchionni, Guglielmo Gregorio, Ugo De Patto, Mario Padovan
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Patent number: 5026801Abstract: This invention is directed to halodihydrodioxins, their preparation and their polymers, which provide amorphous homopolymers that are resistant to ring opening side reactions. The resulting polymers can be used for films and thermally stable molded objects, coatings for substrates such as wood, glass, paper and metal and for protective packaging. This invention also concerns the preparation of polyhalogenated dioxoles.Type: GrantFiled: September 18, 1989Date of Patent: June 25, 1991Assignee: E. I. Du Pont de Nemours and CompanyInventors: Carl G. Krespan, Paul R. Resnick
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Patent number: 4827002Abstract: There are prepared compounds of general formula: ##STR1## wherein: R.sub.1 =H, or alkyl or acyl containing from 1 to 10 carbon atoms, R.sub.2, R.sub.3, like or unlike each other, may be H, or an alkyl containing from 1 to 10 carbon atoms and where R.sub.1 and R.sub.2 may form, together, an alkylene group containing from 2 to 10 carbon atoms, and optionally including up to 2 oxygen atoms in the chain, by means of addition reaction induced by radicalic starters of 1,2-dichlorodifluoroethylene to alcohols, ethers or esters of general formula: ##STR2## wherein: R.sub.1, R.sub.2, R.sub.3 are defined as above.Type: GrantFiled: May 31, 1985Date of Patent: May 2, 1989Assignee: Montefluos S.P.A.Inventors: Alberto Fontana, Silvana Modena, Giovanni Moggi
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Patent number: 4755323Abstract: New 1,4-dioxanes of the formula I ##STR1## wherein R.sup.1 and R.sup.2 each signify and alkyl group with 1 - 10 C-atoms, wherein one or two CH.sub.2 groups can also be replaced by O-atoms, F, Cl, Br or CN,R.sup.2 also H,A.sup.1 and A.sup.2 each signify 1,4-phenylene, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,4-dioxane-2,5-diyl, peperidine-1,4-diyl, 1,4-bicyclo(2,2,2)-octylene or pyrimidine-2,5-diyl groups, unsubstituted or substituted by 1 - 4 F-atoms,Z.sup.1 and Z.sup.2 each signify --CO--O--, --O--CO--, CH.sub.2 CH.sub.2 --, OCH.sub.2 -- --CH.sub.2 O-- or a single bond,m and n each signify 0, 1, 2 or 3,(m+n), however, are at least 1 and at most 3,whereby for m=2 or 3, the groups A.sup.1 and for n=2 or 3 the groups A.sup.2 can each be the same or different from one another,as well as the acid-addition salts of the basic ones of these compounds,are suitable for use as components of liquid-crystalline dielectrics.Type: GrantFiled: March 13, 1986Date of Patent: July 5, 1988Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rudolf Eidenschink, Georg Weber
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Patent number: 4736045Abstract: Fluorinated ether, process for their preparation, and use of the fluorinated ethers as inert fluids.Type: GrantFiled: September 11, 1984Date of Patent: April 5, 1988Inventors: Frederick G. Drakesmith, Richard L. Powell, Richard D. Chambers, Brian Grievson
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Patent number: 4677213Abstract: Dioxane derivatives are disclosed which are represented by the formula (I): ##STR1## wherein, R stands for a hydrogen atom or an aliphatic residue having 1 to 10 carbon atoms; R.sup.1 and R.sup.2 stand for a hydrogen atom or a hydrocarbon residue having 1 to 10 carbon atoms, respectively; and R, R.sup.1 and R.sup.2 which exist plurally may be the same or different, respectively.Such dioxane derivatives (I) are produced by reacting a glycolaldehyde represented by the formula (II) ##STR2## with an amine represented by the formula (III)R--NH.sub.2 (III)wherein R, R.sup.1 and R.sup.2 are as defined above.The dioxane derivatives (I) are useful for production of serine derivatives as well as utilized for separation and purification of glycolaldehydes (II).Type: GrantFiled: November 14, 1984Date of Patent: June 30, 1987Assignee: Research Association for Utilization of Light OilInventors: Sadao Kitagawa, Takashi Yokoi, Mitsumasa Kaito
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Patent number: 4575560Abstract: The invention is insecticidal diaminoguanidine hydrazone compounds which are also effective antifeeding agents for insects and methods for their preparation.Type: GrantFiled: February 25, 1985Date of Patent: March 11, 1986Assignee: American Cyanamid CompanyInventors: Roger W. Addor, Donald P. Wright, Jr., Jack K. Siddens, John J. Hand
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Patent number: 4470843Abstract: Herbicide antidote compounds having the formula ##STR1## in which X and X' are halogens, independently selected from the group consisting of chlorine, bromine and iodine; andR is selected from the group consisting of alkyl having 1-12 carbon atoms, inclusive; halophenyl wherein halo is selected from the group consisting of chlorine, bromine and iodine; and substituted alkoxy carbonyl wherein the alkoxy group has 1-8 carbon atoms, inclusive and the substituents are halogen selected from the group consisting of chlorine, fluorine, and iodine; or dioxane.Type: GrantFiled: October 14, 1980Date of Patent: September 11, 1984Assignee: Stauffer Chemical CompanyInventor: Kent E. Matsumoto
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Patent number: 4343742Abstract: 2,3-Perfluoro-1,4-dioxanes of the formula I ##STR1## wherein X and Y independently from one another mean F or CF.sub.3, are manufactured by reacting carbonyl compounds of the formula II ##STR2## wherein X has the same meaning as in formula I,Y' has the same meaning as Y in formula I (F, CF.sub.3), and additionally can be Cl andZ=Cl, mesylate [=OSO.sub.2 CH.sub.3 ] or tosylate=[OSO.sub.2 C.sub.4 H.sub.6 --CH.sub.3 (p)],with alkali metal fluorides and/or with ammonium fluoride. The reaction products I, among which those wherein at least one of both radicals X and Y is CF.sub.3 are novel compounds, are solvents for highly fluorinated compounds and intermediates in various application fields.Type: GrantFiled: January 14, 1981Date of Patent: August 10, 1982Assignee: Hoechst AktiengesellschaftInventors: Herbert Muffler, Gunter Siegemund, Werner Schwertfeger
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Patent number: 4330475Abstract: A method and apparatus for improving direct fluorinations are disclosed in which the material to be fluorinated is formed into an aerosol prior to fluorination.Type: GrantFiled: December 6, 1979Date of Patent: May 18, 1982Inventors: James L. Adcock, Ehrengard B. Renk