Pentacyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/382)
  • Patent number: 9828355
    Abstract: The material for forming an underlayer film for lithography of the present invention contains a compound represented by the following general formula (1). (in formula (1), each X independently represents an oxygen atom or a sulfur atom, R1 represents a single bond or a 2n-valent hydrocarbon group having 1 to 30 carbon atoms, the hydrocarbon group may have a cyclic hydrocarbon group, a double bond, a hetero atom or an aromatic group having 6 to 30 carbon atoms, and each R2 independently represents a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an alkenyl group having 2 to 10 carbon atoms, or a hydroxyl group, provided that at least one R2 represents a hydroxyl group, each m is independently an integer of 1 to 4, n is an integer of 1 to 4, and p is 0 or 1.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: November 28, 2017
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Masatoshi Echigo, Takashi Makinoshima, Naoya Uchiyama
  • Patent number: 9328123
    Abstract: The present invention relates to rotenone derivatives and a use of the same. Particularly, the present inventors identified rotenoisin A and B which are compounds with no toxicity and which are prepared by irradiation with gamma rays onto rotenone as represented by the following formula 1. It was further confirmed that the rotenone derivatives significantly inhibited pancreatic lipase activity and preadipocyte differentiation. The rotenone derivatives of the present invention can be effectively used as a composition for the prevention and treatment of obesity and as a composition for health functional food for the prevention and improvement of obesity: (In formula 1, R1 and R2 are as defined in this description).
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: May 3, 2016
    Assignee: Korea Atomic Energy Research Institute
    Inventors: Byung Yeoup Chung, Tae Hoon Kim, Seung Sik Lee, Hyoungwoo Bai, Sungbeom Lee, Chul Hong Park
  • Patent number: 9309561
    Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: April 12, 2016
    Assignee: Applied Biosystems, LLC
    Inventors: Joe Y. L. Lam, Scott C. Benson, Steven M. Menchen
  • Patent number: 9073838
    Abstract: The present invention relates to a method of making indeno-fused naphthol materials, that involves, with some embodiments, forming an indanone acid intermediate, represented by the following general Formula V, With Formula V, m is from 0 to 4, and R1 for each m, Rg and Rh can each be independently selected from, for example, hydrogen and hydrocarbyl.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: July 7, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Anu Chopra, Barry Van Gemert, Wenjing Xiao, Huayun Yu
  • Publication number: 20150137111
    Abstract: A compound for an organic optoelectronic device, an organic light-emitting device including the same and a display device including the organic light-emitting device are provided, and the compound for an organic optoelectronic device represented by a combination of the following Chemical Formulae 1 and 2 is provided and thus an organic light-emitting device has improved life-span characteristics due to excellent electrochemical and thermal stability, and high luminous efficiency at a low driving voltage.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 21, 2015
    Inventors: Dong-Wan RYU, Nam-Heon LEE, Han-Ill LEE, Sung-Hyun JUNG, Young-Kyoung JO, Mi-Young CHAE, Dal-Ho HUH, Jin-Seok HONG
  • Patent number: 9034219
    Abstract: Described herein are compounds generally comprising an indeno[2?,3?:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles. Also described herein are methods for preparing certain photochromic compounds, compositions, and articles.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: May 19, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Darrin R. Dabideen, Xiao-Man Dai, Wenjing Xiao, Ruisong Xu, Sujit Mondal, Anil Kumar, Anu Chopra
  • Patent number: 9028728
    Abstract: The present invention relates to photochromic materials that include one or more indeno-fused naphthopyrans that have particular groups at the 7, 11, and 13 positions thereof, and at the position alpha to the oxygen of the pyran ring thereof. With some embodiments, hydrogen or an alkoxy group is bonded to the 7 position, an optionally substituted phenyl is bonded to the 11 position, two alkyl groups are bonded to the 13 position, and two optionally substituted phenyl groups are bonded to the position alpha to the oxygen of the pyran ring of the indeno-fused naphthopyran compound. The 13 position of the indeno-fused naphthopyrans is free of ether groups in which an ether oxygen is bonded to the 13 position, and hydroxyl. The present invention also relates to photochromic articles and compositions that include such indeno-fused naphthopyrans.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: May 12, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Kevin E. Bancroft, Anu Chopra, Xiao-Man Dai, Beon-Kyu Kim, David B. Knowles, Jason R. Lewis, Victor A. Montes, Stephen D. Straight, Massimiliano Tomasulo, Barry Van Gemert, Robert W. Walters, Wenjing Xiao, Huayun Yu, Elizabeth A. Zezinka
  • Publication number: 20150111842
    Abstract: Provided are an attractant for bone marrow stem cells containing at least one of cinnamtannin B1 and pentagalloylglucose, and a method for attracting bone marrow stem cells in which bone marrow stem cells are attracted by the attractant.
    Type: Application
    Filed: May 31, 2013
    Publication date: April 23, 2015
    Applicants: PIAS CORPORATION, OSAKA UNIVERSITY
    Inventors: Tadashi Furumoto, Koichi Nakaoji, Kazuhiko Hamada, Noriyasu Ozawa, Yuta Inami, Misaki Toyoshima, Kosuke Fujita, Akito Maeda, Yasufumi Kaneda, Katsuto Tamai
  • Patent number: 9006427
    Abstract: Various photochromic materials are provided that are essentially free of polymerizable unsaturated groups, and comprise: a) an indeno[2?,3?:3,4]naphtho[1,2-b]pyran; and b) an electron-withdrawing, non-conjugating group bonded at the 11-position of the indeno[2?,3?:3,4]naphtho[1,2-b]pyran. Alternative embodiments include various substituents at other positions of the indeno[2?,3?:3,4]naphtho[1,2-b]pyran.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: April 14, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Anu Chopra, Patrick M. Brown
  • Publication number: 20150090691
    Abstract: Material for forming an underlayer film for lithography, which has a high carbon concentration, a low oxygen concentration, a relatively high heat resistance and also a relatively high solvent solubility, and which can be applied to a wet process is disclosed. Material for forming an underlayer film for lithography contains a compound represented by general formula (1).
    Type: Application
    Filed: August 9, 2012
    Publication date: April 2, 2015
    Applicant: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Masatoshi Echigo, Go Higashihara, Naoya Uchiyama
  • Publication number: 20150034887
    Abstract: A novel photochromic compound which develops a color of a neutral tint (double peak characteristic) and has high color optical density, high fading speed and excellent durability. Like a compound represented by the following formula (20), the photochromic compound having a group (methylthio group in the following formula 20) which has a sulfur atom bonded to the 7-position carbon atom is a photochromic compound having high color optical density, high fading speed and excellent durability.
    Type: Application
    Filed: March 11, 2013
    Publication date: February 5, 2015
    Applicant: TOKUYAMA CORPORATION
    Inventors: Shinobu Izumi, Yasutomo Shimizu, Junji Momoda
  • Patent number: 8920928
    Abstract: Described herein are compounds generally comprising an indeno[2?,3?:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: December 30, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Darrin R. Dabideen, Sujit Mondal, Xiao-Man Dai, Ruisong Xu, Wenjing Xiao, Massimiliano Tomasulo, Huayun Yu, Anu Chopra, Anil Kumar
  • Patent number: 8916071
    Abstract: A chromene compound which has a sulfur-containing substituent represented by the following formula (2) at the 6-position and/or 7-position carbon atom of an indeno(2,1-f)naphtho(1,2-b)pyran structure and is excellent in photochromic properties and stability at a high temperature. In the formula (2), ring X is an aromatic hydrocarbon ring or aromatic heterocyclic ring, R3 and R4 are each independently an alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, amino group, heterocyclic group containing a ring member nitrogen atom and bonded to the ring X bonded thereto via the nitrogen atom, halogen atom, aryloxy group or aryl group, and “a” is an integer of 0 to 4.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: December 23, 2014
    Assignee: Tokuyama Corporation
    Inventors: Yasutomo Shimizu, Shinobu Izumi, Junji Takenaka, Junji Momoda
  • Publication number: 20140364490
    Abstract: The present invention relates to the fields of natural medicine and medicinal chemistry, and more particularly to a 1-oxo/acylated-14-acylated oridonin derivative of a general formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the compounds, a pharmaceutical composition comprising the compounds, and application thereof in preparation of antitumor drugs.
    Type: Application
    Filed: January 21, 2013
    Publication date: December 11, 2014
    Applicant: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.
    Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai
  • Patent number: 8901298
    Abstract: The present invention relates to condensed aromatic compounds with multiple ring bridging of the general formulae (1), (2), (3), (4) and (5). The invention furthermore relates to the use of the compounds according to the invention in an organic electronic device and to a process for the preparation of the compounds according to the invention. The invention furthermore relates to an electronic device which comprises the compounds according to the invention.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: December 2, 2014
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Christof Pflumm, Holger Heil, Arne Buesing
  • Publication number: 20140309418
    Abstract: Gambogenic acid derivatives having a structure shown as Formula (I) or (II), salts, preparation method and application thereof in the treatment of tumor. Compared with gambogenic acid, the gambogenic acid derivatives exhibit more potent anti-tumor activities.
    Type: Application
    Filed: September 28, 2012
    Publication date: October 16, 2014
    Inventors: Wantao Chen, Xu Wang, Zhiyuan Zhang, Chenping Zhang, Li Mao, Ping Zhang, Qin Xu, Ming Yan, Jianjun Zhang, Jinsong Pan, Yan Lv, Rongxin Deng, Weiliu Qiu
  • Patent number: 8859097
    Abstract: The present invention provides a compound represented by the Formula I: wherein substituents R16 and R17? are each independently selected from an electron withdrawing group have a Hammett ?p value of from 0.05 to 0.85 and R17 is hydrogen.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: October 14, 2014
    Assignee: Transitions Optical, Inc.
    Inventor: Anu Chopra
  • Publication number: 20140275233
    Abstract: The present invention provides, among other things, compositions and methods of manufacturing edible soy pod fiber comprising glyceollins. In some embodiments, methods of treating overweight, obesity, prediabetes, diabetes, or gastrointestinal dysbiosis in a subject are provided comprising orally administering a composition or food product comprising edible soy pod fiber comprising glyceollins.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventor: Mark L. Heiman
  • Patent number: 8835489
    Abstract: This invention belongs to the chemical-pharmaceutical field. New compounds of pterocarpanquinone family presented in formula (I) according to this invention are capable to be activated by reduction generating alkylating species intracellularly. It presents selective cytotoxic effects particularly on mammalian human and nonhuman cells that divide constantly and are useful in treating diseases and dysfunctions related to the phenomenon of undesired cell proliferation. Such compounds are also effective for the treatment of diseases or dysfunctions related to high levels of TNF-? in human and nonhuman mammals.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: September 16, 2014
    Assignee: Universidade Federal Do Rio de Janeiro
    Inventors: Alcides Jose Monteiro Da Silva, Vivian Mary Barral Dold Rumjanek, Bartira Rossi Bergmann, Eduardo Salustiano Jesus Dos Santos, Paulo Roberto Ribeiro Costa, Chaquip Daher Netto, Wallace Pacienza Lima, Eduardo Caio Torres Dos Santos, Moises Clemente Marinho Cavalcante, Sergio Henrique Seabra, Ingred Goretti Rica
  • Publication number: 20140248561
    Abstract: A resist composition containing a compound represented by the general formula (1) or (2), a method for forming a resist pattern using the composition, a polyphenolic compound for use in the composition, and an alcoholic compound that can be derived therefrom are described.
    Type: Application
    Filed: August 9, 2012
    Publication date: September 4, 2014
    Applicant: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Masatoshi Echigo, Masako Yamakawa
  • Publication number: 20140242665
    Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.
    Type: Application
    Filed: February 24, 2014
    Publication date: August 28, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Joe Y. LAM, Steven MENCHEN, Ruiming ZOU, Scott BENSON
  • Publication number: 20140225049
    Abstract: The present invention provides ophthalmic devices comprising at least one photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.
    Type: Application
    Filed: April 22, 2014
    Publication date: August 14, 2014
    Applicant: Johnson & Johnson Vision Care, Inc.
    Inventors: Anu Chopra, Jun Deng, Beon-Kyu Kim, David B. Knowles, Frank F. Molock, JR., Victor A. Montes, Stephen D. Straight, Wenjing Xiao, Huayun Yu
  • Patent number: 8795955
    Abstract: A naphthalene derivative having formula (1) is provided wherein cyclic structures Ar1 and Ar2 denote a benzene or naphthalene ring, X is a single bond or C1-C20 alkylene, m is 0 or 1, and n is such a natural number as to provide a molecular weight of up to 100,000. A material comprising the naphthalene derivative or a polymer comprising the naphthalene derivative is spin coated to form a resist bottom layer having improved properties. A pattern forming process in which a resist bottom layer formed by spin coating is combined with an inorganic hard mask formed by CVD is available.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: August 5, 2014
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeshi Kinsho, Katsuya Takemura, Daisuke Kori, Takeru Watanabe, Tsutomu Ogihara
  • Patent number: 8778236
    Abstract: A novel photochromic compound which develops a color of a neutral tint and has high color optical density, high fading speed and excellent durability. The present invention is a chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as the basic skeleton in which a hetero ring having two hetero atoms including at least one sulfur atom is directly bonded to the 6-position and the 7-position of the indeno(2,1-f)naphtho(1,2-b)pyran structure via the hetero atom like the compound represented by the following formula (18).
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: July 15, 2014
    Assignee: Tokuyama Corporation
    Inventors: Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Toshiaki Takahashi, Mitsuyoshi Sando, Shinobu Izumi
  • Patent number: 8765978
    Abstract: The present invention relates to a method of making indeno-fused naphthol materials, that involves, with some embodiments, forming an indanone acid intermediate, which can be represented by the following general Formula V, With Formula V, m is from 0 to 4, and R1 for each m, Rg and Rh can each be independently selected from, for example, hydrogen and hydrocarbyl. The present invention also relates to a method of making an indeno-fused naphthopyran that involves an indanone acid intermediate synthetic route.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: July 1, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Anu Chopra, Barry Van Gemert, Wenjing Xiao, Huayun Yu
  • Publication number: 20140166948
    Abstract: The present invention relates to compounds represented by the following Formula (II), Ring-A of Formula II can be, for example, an aryl group, and Q? and Q?? can each be independently selected from groups, such as, halogen, —OH, —CN, amine groups, amide groups, carboxylic acid ester groups, carboxylic acid groups, alkenyl groups, alkynyl groups, carbonate groups, sulfide groups, and sulfonic acid ester groups. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds such as represented by Formula II.
    Type: Application
    Filed: February 19, 2014
    Publication date: June 19, 2014
    Inventors: Meng He, Anil Kumar, Darrin R. Dabideen
  • Patent number: 8748634
    Abstract: Various photochromic materials are provided that are essentially free of polymerizable unsaturated groups, and comprise: a) an indeno[2?,3?:3,4]naphtho[1,2-b]pyran; and b) an electron-withdrawing, non-conjugating group bonded at the 11-position of the indeno[2?,3?:3,4]naphtho[1,2-b]pyran. Alternative embodiments include various substituents at other positions of the indeno[2?,3?:3,4]naphtho[1,2-b]pyran. Also provided are photochromic articles including a substrate and one of the above photochromic materials, in contact with at least a portion of the substrate.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: June 10, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Anu Chopra, Patrick M. Brown
  • Publication number: 20140155598
    Abstract: Various photochromic materials are provided that are essentially free of polymerizable unsaturated groups, and comprise: a) an indeno[2?,3?:3,4]naphtho[1,2-b]pyran; and b) an electron-withdrawing, non-conjugating group bonded at the 11-position of the indeno[2?,3?:3,4]naphtho[1,2-b]pyran. Alternative embodiments include various substituents at other positions of the indeno[2?,3?:3,4]naphtho[1,2-b]pyran.
    Type: Application
    Filed: February 7, 2014
    Publication date: June 5, 2014
    Applicant: TRANSITIONS OPTICAL, INC.
    Inventors: Anu Chopra, Patrick M. Brown
  • Patent number: 8741188
    Abstract: The present invention provides ophthalmic devices comprising at least one photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: June 3, 2014
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Anu Chopra, Jun Deng, Beon-Kyu Kim, David B. Knowles, Frank F. Molock, Jr., Victor A. Montes, Stephen D. Straight, Wenjing Xiao, Huayun Yu
  • Patent number: 8722727
    Abstract: Novel derivatives of enfumafungin are disclosed herein, along with' their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: May 13, 2014
    Assignee: Seynix, Inc.
    Inventors: Mark L. Greenlee, Robert Wilkening, James Apgar, Donald Sperbeck, Kenneth J. Wildonger, Dongfang Meng, Dann L. Parker, Jr., Ahmed Mamai
  • Publication number: 20140120628
    Abstract: Embodiments of near-infrared (NIR) dyes are disclosed, along with methods and kits for detecting analytes with the NIR dyes. The NIR dyes have a structure according to the general structure At least one of R1/R2, R2/R3, R3/R4, R5/R6, R6/R7, and/or R7/R8 together forms a substituted or unsubstituted cycloalkyl or aryl.
    Type: Application
    Filed: June 29, 2012
    Publication date: May 1, 2014
    Applicant: The Oregon State Board of Higher Education on Behalf of Portland State University
    Inventors: Robert Michael Strongin, Martha Sibrian-Vazquez, Jorge Omar Escobedo-Cordova, Mark Allen Lowry
  • Patent number: 8709308
    Abstract: The chromene compound is represented by the following formula (I), wherein R3 at the 11-position is a sulfur-containing substituent selected from the group consisting of thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group, heteroarylthio group, sulfonyl group and sulfinyl group, R1 and R2 at the 6-position and the 7-position are a combination of an aryl group or a heteroaryl group and an electron donating group having a Hammett constant ?p of ?0.1 or less, or R1 and/or R2 is sulfur-containing substituent selected from thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group and heteroarylthio group.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 29, 2014
    Assignee: Tokuyama Corporation
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Mitsuyoshi Sando, Shinobu Izumi
  • Patent number: 8698117
    Abstract: The present invention relates to compounds represented by the following Formulas (I) and (II), Ring-A of Formulas I and II can be, for example, an aryl group, and Q? and Q?? can each be independently selected from groups, such as, halogen, —OH, —CN, amine groups, amide groups, carboxylic acid ester groups, carboxylic acid groups, alkenyl groups, alkynyl groups, carbonate groups, sulfide groups, and sulfonic acid ester groups. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds, such as represented by Formula II.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: April 15, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Anil Kumar, Darrin R. Dabideen
  • Patent number: 8691120
    Abstract: A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett constant ?p of not more than ?0.1 at the 7-position carbon atom.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: April 8, 2014
    Assignee: Tokuyama Corporation
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Mitsuyoshi Sando, Kazuhiro Teranishi
  • Publication number: 20140042377
    Abstract: A photochromic polymer comprising at least two photochromic moieties linked by a straight or branched chain polymer selected from the group consisting of poly(C2 to C4 alkylene oxide), poly[C1 to C10 alkoxy substituted (C2 to C4 alkylene oxide)] and poly[C1 to C-15 acyloxy substituted (C2 to C4 alkylene oxide)].
    Type: Application
    Filed: May 2, 2012
    Publication date: February 13, 2014
    Applicant: VIVIMED LABS EUROPE LTD
    Inventors: Richard Alexander Evans, Nino Malic
  • Patent number: 8647538
    Abstract: The present invention relates to photochromic compounds that include at least two photochromic moieties that are linked together by a multivalent linking group. The multivalent linking group can be selected so as to be flexible and/or substantially prevent electronic interaction between any two photochromic moieties through the multivalent linking group. The present invention also relates to photochromic compositions and articles that include at least a photochromic amount of one or more photochromic compounds of the present invention.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: February 11, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Yunyi Lu, Wenjing Xiao, Robert W. Walters, Feng Wang, M. Frank Haley, Jason R. Lewis, Anu Chopra, Beon-Kyu Kim, Huayun Yu
  • Publication number: 20140034884
    Abstract: A chromene compound which develops a color of a neutral tint and has little initial coloration, high double peak characteristic and high color development sensitivity, rarely experiences the reduction of color optical density though it has high fading speed, is excellent in the durability of photochromic properties and can dissolve in a monomer composition which will become a substrate for optical articles in a high concentration, and a photochromic curable composition comprising the chromene compound and polymerizable monomers. The chromene compound is represented by the following formula (1).
    Type: Application
    Filed: January 26, 2012
    Publication date: February 6, 2014
    Applicant: TOKUYAMA CORPORATION
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Mitsuyoshi Sando, Shinobu Izumi
  • Patent number: 8642766
    Abstract: An in vitro synthesis of (+) cortistatin A from readily available precursors is disclosed, as are the syntheses of related 17-aryl substituted compounds, the 17-aryl substituted compounds themselves and novel compounds useful in their preparation.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: February 4, 2014
    Inventors: Ryan A. Shenvi, Carlos A. Guerrero, Jun Shi, Chuang-Chuang Li, Phil S. Baran
  • Publication number: 20140027684
    Abstract: A photochromic polymer comprising at least two photochromic moieties linked by a straight or branched chain polymer selected from the group consisting of a homo-polyester, a co-polyester, and a co-polyester-polyether.
    Type: Application
    Filed: May 21, 2012
    Publication date: January 30, 2014
    Applicant: VIVIMED LABS EUROPE LTD
    Inventors: Richard Alexander Evans, Nino Malic, Ian John Dagley
  • Publication number: 20140018552
    Abstract: The present invention provides an AGE inhibitor and a health functional food for inhibiting an occurrence of diabetic complications. Particularly, the present invention comprises a compound selected from the group consisting of mulberrofuran G, mulberrofuran K, kuwanon G, kuwanon Z, oxyresveratrol, 2?,4?,5,7-tetrahydroxyflavanone, morusignin L and dihydromorin isolated from Morus Bark as an active ingredient. The compounds disclosed above inhibit the production of AGE which is a causative substance of diabetic complications. Thus, the compounds could be used as an AGE inhibitor and a health functional food for inhibiting diabetic nephropathy, diabetic retinopathy and diabetic neuropathy.
    Type: Application
    Filed: March 26, 2012
    Publication date: January 16, 2014
    Applicant: Dong Wha Pharm. Co., Ltd.
    Inventors: Hwan Bong Chang, Joobyoung Yoon, Hyun Yong Lee, Hyun Sik Choi, Hyung Bok Lee
  • Publication number: 20140004214
    Abstract: The invention provides a method of isolating one or more compounds present in fruit juice or seed extracts that have anti-microbial activity.
    Type: Application
    Filed: June 14, 2013
    Publication date: January 2, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Brant Lawrence Kedrowski, Teri Shors
  • Patent number: 8618161
    Abstract: Fluorescent polymeric materials are disclosed comprising a polymeric particle and one or more lipid soluble rhodamine dyes, comprising the following core structure: wherein R11 and R15 are each H or are each F or Cl; R12, R13, and R14 are each H or are each F or Cl; and wherein at least one of R3?, R3?, R6? and R6? is a (C4-C20) alkyl. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: December 31, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson
  • Patent number: 8618123
    Abstract: Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimer's disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: December 31, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Thavalakulamgara K. Sasikumar, Duane A. Burnett, Theodros Asberom, Wen-Lian Wu, Hongmei Li, Ruo Xu, Hubert B. Josien
  • Publication number: 20130273380
    Abstract: The present invention relates to controlled radical polymerization (CRP) initiators that include at least one radically transferable group. The CRP initiators include at least one of the following, (a) a spirooxazine compound represented by the following Formula (I), and (b) an indenonaphthopyran represented by the following Formula (II), One or more of R1, R2, R3, R4, R5, and R6 of the spirooxazine, and one or more of R7, R8, R9, R10, B, and B? independently include the radically transferable group. The present invention also relates to polymers, such as mechanochromic polymers, that are prepared from such CRP initiators, polymer compositions that include such polymers, and mechanochromic articles that include such polymer compositions.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 17, 2013
    Inventors: Charles R. Hickenboth, Cynthia Kutchiko, Matthew J. Kryger
  • Patent number: 8551448
    Abstract: The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are useful in, for example, clinical imaging applications as tracers to measure cardiac blood flow and detect regions of ischemia.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: October 8, 2013
    Assignee: The Regents of the University of California
    Inventors: Henry F. VanBrocklin, James P. O'Neil, Andrew R. Gibbs, Nandanan Erathodiyil
  • Patent number: 8545984
    Abstract: Described herein are compounds generally comprising an indeno[2?,3?:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles. Also described herein are methods for preparing certain photochromic compounds, compositions, and articles.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: October 1, 2013
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Darrin R. Dabideen, Anil Kumar, Ruisong Xu
  • Patent number: 8518546
    Abstract: The present invention relates to compounds represented by the following Formula I, Ring-A of the Formula I can be, for example an aryl group, and L1 is a chiral or achiral lengthening group. The compound represented by Formula I can be a photochromic compound. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds, such as represented by Formula I.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: August 27, 2013
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Sujit Mondal, Darrin R. Dabideen, Anil Kumar, Xiao-Man Dai
  • Patent number: 8518305
    Abstract: The present invention relates to photochromic materials that include a photochromic compound that includes a photochromic substituent (e.g., an indeno-fused naphthopyran) and at least one pendent silane group, which is bonded to the photochromic substituent. The pendent silane groups are selected from certain pendent siloxy-silane groups and/or pendent alkoxy-silane groups represented by general formulas (I) and/or (II) as described in further detail herein. The present invention also relates to photochromic articles, such as photochromic optical elements (e.g., photochromic lenses), and photochromic coating compositions (e.g., curable photochromic coating compositions), that include the photochromic materials of the present invention. The photochromic materials of the present invention have improved compatibility with compositions into which they may be incorporated, for example, coating compositions, such as urethane coating compositions.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: August 27, 2013
    Assignee: Transitions Optical, Inc.
    Inventor: Massimiliano Tomasulo
  • Patent number: 8507549
    Abstract: Methods for synthesizing glycinols, glyceollins I and II, and isoflavene and chromane compounds using a Wittig reaction, compositions made therewith, and uses thereof are described.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: August 13, 2013
    Assignee: The University of Toledo
    Inventors: Paul W. Erhardt, Rahul S. Khupse, Amarjit Luniwal
  • Patent number: 8486312
    Abstract: The present invention relates to photochromic naphthopyrancs having a double-bridged terphenyl sub-unit, and to the use thereof in plastics of all types, particularly for ophthalmic purposes.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: July 16, 2013
    Assignee: Rodenstock GmbH
    Inventors: Manfred Melzig, Yven Rohlfing, Udo Weigand