Abstract: Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.

Abstract: The invention relates to substituted dihydrobenzopyrans carboxylates of the formula: ##STR1## wherein A is a methylene chain having 1-10 carbon atoms, inclusive, optionally substituted by hydroxy;wherein V is:(a) hydrogen;(b) hydroxy;(c) .dbd.O; or(d) R.sub.6 CH.sub.2 O--;wherein R.sub.1 is:(a) --COCH.sub.3 ;(b) --CHOHCH.sub.3 ;(c) --C.sub.2 H.sub.5 ;(d) -hydrogen; or(e) --COOC.sub.2 H.sub.5wherein R.sub.2 is:(a) -hydrogen;(b) -hydroxy; or(c) R.sub.12 CH.sub.2 CO.sub.2 --;wherein R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 each of which may be the same or different, are:(a) hydrogen;(b) lower-alkyl having 1-6 carbon atoms inclusive; or(c) allyl;wherein R.sub.5 is:(a) hydrogen; or(b) R.sub.7 CH.sub.2 C(O)--;wherein R.sub.13 is hydrogen, hydroxy, alkoxy of 1 to 6 carbon atoms inclusive, or --OM wherein M is an alkali metal, alkyl of 1 to 6 carbon atoms, inclusive, or NR.sub.8.sup..sym. R.sub.9 R.sub.10 R.sub.11, or HNR.sub.8.sup..sym. R.sub.9 R.sub.

Abstract: A novel 2-methylchromone derivative represented by the general formula: ##STR1## wherein R.sub.1 means a hydrogen atom or a lower alkanoyl group. The above derivative is a useful intermediate for the synthesis of cephem activities, which are also effective against infections of the urinary tract, etc. A preparation process of the above chromone derivative is also disclosed.

Abstract: There are described novel dihydropyrones of the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently of one another are each a C.sub.1 -C.sub.4 -alkyl group, or one of the two substituents is also hydrogen, or R.sub.1 and R.sub.2 jointly form a C.sub.2 -C.sub.6 -alkylene bridge, R.sub.3 is C.sub.1 -C.sub.4 -alkoxy, C.sub.2 -C.sub.6 -alkenyloxy, C.sub.2 -C.sub.4 -alkynyloxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.3 -C.sub.5 -alkoxyalkoxy or hydroxyl, and X, Y and Z independently of one another are each hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, --S(O).sub.n -C.sub.1 -C.sub.4 -alkyl, --S(O).sub.n -C.sub.1 -C.sub.4 -haloalkyl, where n is 0, 1 or 2, or they are each C(O)OR.sub.4, where R.sub.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl, or they are each NO.sub.2, CN or NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 independently of one another are each hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.

Abstract: There is described a process for the production of a 1,4-dihydro-4-oxo-quinoline-2-carboxylic acid, or a salt, ester or amide thereof, which comprises cyclization of a corresponding 2-aminobenzoyl pyruvic acid or an ester thereof, and if desired or necessary converting the resulting product to an appropriate salt, ester or amide thereof, or vice versa.

Abstract: A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,R.sub.1 represents a member selected from the group consisting of a C.sub.3 -C.sub.5 alkyl group, a hydroxy-(C.sub.3 -C.sub.5 alkyl) group, a lower alkylamino-lower alkyl group, a nitrato-(C.sub.3 -C.sub.5 alkyl) group and a phenyl-(C.sub.1 -C.sub.5) alkyl group, provided that the phenyl may be substituted by a lower alkoxy group, R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, NO.sub.2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group and acetyl group,R.sub.3 represents hydrogen or NO.sub.2,B represents a direct bond, a C.sub.1 -C.sub.7 alkylene group, a --O-lower alkylene group or a --CONH-lower alkylene group, andn represents 1 or 2;and an acid addition salt thereof and a pharmaceutical composition comprising aforesaid compound.

Abstract: Dyestuffs of the formulaD--N.dbd.N--A Iin whichD represents the radical of a diazo component andA represents the radical of a coupling component of the formulae ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 designate hydrogen or non-ionic radicals,R designates hydrogen or an optionally substituted alkyl, cycloalkyl, aryl, aralkyl or heterocyclic radical,X designates OH or ##STR2## T designates the remaining members of a fused-on ring and Y and Z designate hydrogen, optionally substituted alkyl or optionally substituted aryl,processes for their preparation and process for pigmenting organic material using the dyestuffs of the formula I.

Abstract: There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.

Abstract: Compounds of the formula Het-O-CH.sub.2 -CHOR-CH.sub.2 -NH-aralkyl where Het is ##STR1## are disclosed. The compounds are useful as pharmaceuticals.

Abstract: N-(Substituted chromone-3-carbonyl)phenylglycine derivatives. These derivatives are useful intermediates for cephem compounds which are excellent as antibacterial agents.