Benzene Ring Bonded Directly To The Hetero Ring (e.g., Flavones, Etc.) Patents (Class 549/403)
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Patent number: 8377424Abstract: This invention relates to a method of therapeutic or prophylactic treatment of periodontal disease comprising administering to a subject in need thereof a polymeric compound of formula An. Also disclosed and claimed is an article of manufacture comprising the above compounds packaged within a container with instructions for use, and methods of making thereof.Type: GrantFiled: December 3, 2004Date of Patent: February 19, 2013Assignee: Mars, IncorporatedInventors: Leo J. Romanczyk, Jr., Harold H. Schmitz
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Publication number: 20130040947Abstract: Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-di-hydroxyflavone derivative with modified flavone or heterocyclic ring to a subject in need thereof. Methods and compounds for the treatment of disorders including neurologic disorders, neuropsychiatric disorders, and metabolic disorders (e.g., obesity) are provided.Type: ApplicationFiled: June 8, 2011Publication date: February 14, 2013Applicant: EMORY UNIVERSITYInventor: Keqiang Ye
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Publication number: 20130039854Abstract: A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.Type: ApplicationFiled: July 26, 2012Publication date: February 14, 2013Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Jean C. SHIH, Leland CHUNG, Haiyen E. ZHAU, Boyang Jason WU, Bogdan Z. OLENYUK
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Publication number: 20130035379Abstract: The invention provides a composition for inhibiting proline-directed protein kinase FA/glycogen synthase kinase 3? (PDPK FA/GSK-3?), experiments verified that the composition can effectively inhibit the PDPK FA/GSK-3?. In addition, inhibition of PDPK FA/GSK-3? can improve the clinical efficacy of cancer treatment and cure rate.Type: ApplicationFiled: May 16, 2012Publication date: February 7, 2013Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Shiaw-Der Yang, Hsiao-Hui Fu
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Publication number: 20130029901Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.Type: ApplicationFiled: July 30, 2012Publication date: January 31, 2013Inventors: William M. PIERCE, JR., K. Grant TAYLOR, Leonard C. WAITE, Kevyn MERTEN
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Publication number: 20130023565Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein said PA subunit is from Influenza A 2009 pan-demic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.Type: ApplicationFiled: March 15, 2011Publication date: January 24, 2013Applicant: European Molecular Biology LaboratoryInventors: Stephen Cusack, Eva Kowalinski, Chloe Zubieta
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Publication number: 20130004509Abstract: The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.Type: ApplicationFiled: February 22, 2011Publication date: January 3, 2013Inventor: Levi Garraway
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Publication number: 20120329834Abstract: The present invention relates to the use of compounds of general formula (I): (I) for the preparation of medicaments that act against mitochondrial pathologies involving a deficiency in ATP production via the oxidative phosphorylation pathway, such as mitochondrial diseases.Type: ApplicationFiled: April 15, 2010Publication date: December 27, 2012Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITY OF PITTSBURGH, INSTITUT CURIEInventors: Marc Blondel, Elodie Couplan, Jean-Paul Di Rago, Daniel Dauzonne, Michael Palladino, Alicia Celotto
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Patent number: 8338624Abstract: Isoflavone derivatives are provided comprising a carboxyalkylene moiety linked via its alkylene chain to the aromatic ring and via its carboxy group to an aminoalkyleneamino residue, which, in turn, is covalently linked to a functional group B. The isoflavone derivatives are preferably derived from biochanin A, genistein, and daidzein, and the functional group B is preferably an amino protecting group. These isoflavone derivatives are useful for treating or preventing diseases or disorders associated with estrogen receptor functioning.Type: GrantFiled: February 20, 2008Date of Patent: December 25, 2012Assignees: Yeda Research and Development Co., Ltd., Medical Research and Infrastructure Fund of Tel-Aviv Sourasky Medical CenterInventors: Fortune Kohen, Dalia Somjen, Naftali Stern, Veronica Frydman, Tikva Kulik, Batya Gayer
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Publication number: 20120309739Abstract: The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.Type: ApplicationFiled: November 3, 2010Publication date: December 6, 2012Applicant: ALMAC DISCOVERY LIMITEDInventors: Mark Peter Bell, Colin Roderick O'Dowd, James Samuel Shane Rountree, Graham Peter Trevitt, Timothy Harrison, Mary Melissa McFarland
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Patent number: 8324431Abstract: The invention relates to a process for preparing 2,4-dihydroxyphenyl 4-methoxybenzyl ketones of the formula (I) by Friedel-Crafts acylation in hydrogen fluoride (HF). 2,4-Dihydroxyphenyl 4-methoxybenzyl ketones of the formula (I) in which R1 and R2 are each hydrogen, chlorine, fluorine, bromine, iodine, CF3, methyl, optionally substituted alkoxy, —OCF3, —C(CH3)3, —CH2(CH3)2, —CH(CH3)2, R3 is hydrogen, Cl, F, Br, optionally substituted alkyl, optionally substituted alkoxy, —C(CH3)3, and X is hydroxyl, F, Cl, Br, optionally substituted alkoxy, are obtained in high yield and high purity by reacting phenylacetic acid derivatives of the formula (II) with phenols of the formula (III) in liquid hydrogen fluoride (HF).Type: GrantFiled: February 16, 2008Date of Patent: December 4, 2012Assignee: Plant Health Care, Inc.Inventors: Sergii Pazenok, Norbert Lui
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Publication number: 20120301596Abstract: There is provided a method for manufacturing inexpensive, highly safe, highly stable, versatile polymethoxyflavones that can be used in food products and easily incorporated into a variety of pharmaceutical formulations, whereby in one pass, a large quantity of polymethoxyflavones can be isolated from other components in citrus peel oil, as well as a method for its use. The method for manufacturing polymethoxyflavones from citrus plant peel oil comprises a step of removing the volatile components in citrus plant peel oil by distillation to obtain a distillation residue, a step of distilling the residue with a thin-film vacuum distillation apparatus to obtain a fraction, a step of extracting the fraction with an aqueous ethanol solution to obtain an extract, and a step of contacting active carbon with the extract after removal of the insoluble oils in the extract for refining, as a method for manufacturing polymethoxyflavones that are highly stable over time and have reduced residual pesticide levels.Type: ApplicationFiled: January 29, 2010Publication date: November 29, 2012Applicant: Ogawa & Co LtdInventors: Kenji Adachi, Tsuyoshi Arima, Shuichi Muranishi
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Publication number: 20120295966Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.Type: ApplicationFiled: February 12, 2010Publication date: November 22, 2012Applicant: N30 PHARMACEUTICALS, LLCInventors: Xicheng Sun, Jian Qiu, Jan Wasley
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Publication number: 20120289715Abstract: The invention relates to methods for the preparation of an optically inactive and optically active compounds which are selected from the group consisting of C-3 coupled biflavonoids and C-3 coupled biflavonoid analogues from a starting material or intermediate which are respectively selected from the group consisting of optically inactive or optically active flavan-3-ols and optically active flavan-3-ones, the method comprising the steps of (a) providing an optically inactive or active compound having a flavan-3-ol structure or a compound which is a flavan-3-one, (b) if a compound having a flavan-3-ol structure with a hydroxy group on the C-3 carbon is selected as starting material, converting the hydroxy group on the C-3 carbon of the compound having the flavan-3-ol structure to an oxo group to form a flavan-3-one of that compound, (c) providing a compound having a nucleophilic aromatic moiety, which compound is selected from the group of compounds having a nucleophilic aromatic moiety and which have flavonoType: ApplicationFiled: August 19, 2010Publication date: November 15, 2012Applicant: University of the Free StateInventors: Jan Hendrik Van Der Westhuizen, Susanna Lucia Bonnet, Matthew Achilonu, Miroslav Sisa
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Publication number: 20120289496Abstract: The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.Type: ApplicationFiled: May 4, 2012Publication date: November 15, 2012Applicant: Rhizen Pharmaceuticals SAInventors: Dhanapalan NAGARATHNAM, Swaroop Kumar V.S. Vakkalanka, Meyyappan Muthuppalaniappan, Srikant Viswanadha, Govindarajulu Babu, Prashant K. Bhavar
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Publication number: 20120289716Abstract: Provided are: a method for rapid fluoromethylation, by which a fluoromethyl group can be easily bonded to an aromatic-ring carbon of an aromatic compound with little generation of by-products; and a process for preparation of a PET tracer using the same. The method is characterized by cross-coupling an organoboron compound in which an aromatic ring is bonded to a boron atom with FCX2Br (wherein X is ordinary hydrogen or heavy hydrogen) in a solvent obtained by adding water to an aprotic polar solvent, in the presence of a palladium complex, a phosphine ligand, and a base.Type: ApplicationFiled: December 3, 2010Publication date: November 15, 2012Applicant: RIKENInventors: Masaaki Suzuki, Hisashi Doi, Miki Goto
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Publication number: 20120283313Abstract: The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of identifying inhibitors of metastatic prostate cancer by screening for inhibitors of MEK4.Type: ApplicationFiled: July 23, 2012Publication date: November 8, 2012Applicant: NORTHWESTERN UNIVERSITYInventors: Raymond C. Bergan, Karl A. Scheidt
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Publication number: 20120277300Abstract: Compositions useful for inducing bone growth or inhibiting bone loss in an animal comprising one or more isoflavones or isoflavone metabolites and methods for inducing bone growth or inhibiting bone loss in an animal utilizing such compositions. The compositions and methods are particularly useful for post-menopause, post-andropause, gonadectomized, spayed, or neutered animals.Type: ApplicationFiled: July 2, 2012Publication date: November 1, 2012Inventor: Yuanlong Pan
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Publication number: 20120277298Abstract: The present invention relates to food products comprising flavanones. In particular, it relates to food products comprising hesperidin having improved stability. The present invention also concerns processes for the manufacturing of food products comprising said flavanones, especially hesperidin and to the use of the food products in the manufacture of compositions for the improvement of bone and skin health.Type: ApplicationFiled: July 22, 2010Publication date: November 1, 2012Applicant: NESTEC S.A.Inventor: Pascaline Hoebler
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Publication number: 20120277212Abstract: The present invention provides new oxime derivatives of the general formula (I), pharmaceutical compositions containing them and their use for the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. This invention further provides new oxime derivatives of the general formula (I) consisting of modulators of nervous system receptors sensitive to glutamate, which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. In particular embodiments, the new oxime derivatives of the invention are modulators of metabotropic glutamate receptors (mGluRs). The invention further provides positive allosteric modulators of mGluRs and more specifically positive alSosteric modulators of mGluR4.Type: ApplicationFiled: October 29, 2010Publication date: November 1, 2012Applicants: PRESTWICK CHEMICAL, INC., DOMAIN THERAPEUTICSInventors: Stephan Schann, Stanislas Mayer, Christophe Morice, Bruno Giethlen
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Publication number: 20120264820Abstract: A compound, pharmaceutical composition and method for the treatment of mammals wherein the active therapeutic agent is a compound having the structure: wherein: R1 is an electronegative substituent, R2 is R1 or alkyl, R3 is H or O-alkyl, R4 and R5 are the same or different and are alkyl and R6 is H or OH.Type: ApplicationFiled: December 31, 2007Publication date: October 18, 2012Inventors: Kinfe Redda, Chavonda Janeebra Mills, Nelly Maleeva
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Publication number: 20120245111Abstract: The present invention relates to food products comprising flavanones. In particular, it relates to food products comprising hesperidin having improved stability. The present invention also concerns processes for the manufacturing of food products comprising said flavanones, especially hesperidin and to the use of the food products in the manufacture of compositions for the improvement of bone and skin health. Said flavanones are subjected to heating in water to a temperature of at least 138° C.Type: ApplicationFiled: July 22, 2010Publication date: September 27, 2012Applicant: NESTEC S.A.Inventor: Pascaline Hoebler
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Patent number: 8273906Abstract: It is intended to provide a method for producing aglycone from a glycoside efficiently at low cost without using an acid catalyst or an organic solvent. The method for producing aglycone, characterized by bringing a glycoside into contact with high temperature high pressure water. The temperature of the high temperature high pressure water is generally from 100 to 374° C., preferably from 140 to 320° C., more preferably from 200 to 300° C. The pressure of the high temperature high pressure water may be not lower than the saturated water vapor pressure at the temperature, i.e., a pressure at which the liquid state is maintained.Type: GrantFiled: June 13, 2008Date of Patent: September 25, 2012Assignee: J-Oil Mills, Inc.Inventors: Yosuke Isobe, Shuichi Kamo, Toshiro Sato, Hiroyuki Yoshida
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Publication number: 20120238541Abstract: The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.Type: ApplicationFiled: September 17, 2010Publication date: September 20, 2012Applicant: Almac Discovery LimitedInventors: Mark Peter Bell, Timothy Harrison, Sumita Bhattacharyya, James Samuel Shane Rountree, Frank Burkamp, Stephen Price, Calum MacLeod, Richard Leonard Elliott, Phillip Smith, Toby Jonathan Blench, Colin Roderick O'Dowd, Lixin Zhang, Graham Peter Trevitt, Hazel Joan Dyke
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Patent number: 8263790Abstract: A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.Type: GrantFiled: June 1, 2011Date of Patent: September 11, 2012Assignees: Children's Hospital Medical Center, Girindus America, Inc.Inventors: Kenneth David Reginald Setchell, Victor Dmitrievich Sorokin
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Patent number: 8252835Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases related to estrogen receptor alpha 36, for preventing and/or treating respiratory diseases such as asthma, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.Type: GrantFiled: October 23, 2007Date of Patent: August 28, 2012Assignee: Shenogen Pharma Group Ltd.Inventors: Jin Li, Kun Meng
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Publication number: 20120213842Abstract: The subject invention relates to novel micoparticulate and soluble forms of flavonoids, and their synthesis. The invention also includes novel formulations of such flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.Type: ApplicationFiled: October 22, 2010Publication date: August 23, 2012Inventor: Philip J. Birbara
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Publication number: 20120172424Abstract: Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.Type: ApplicationFiled: March 8, 2012Publication date: July 5, 2012Applicant: MARSHALL EDWARDS, INC.Inventors: Andrew HEATON, Alan Husband
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Publication number: 20120165558Abstract: The present invention relates to microporous molecular sieve materials and their analogue molecular sieve materials having a crystalline unilamellar or multilamellar framework with a single unit cell thickness in which layers are aligned regularly or randomly, the molecular sieve materials being synthesized by adding an organic surfactant to the synthesis composition of zeolite. In addition, the present invention relates to micro-mesoporous molecular sieve materials activated or functionalized by dealumination, ion exchange or other post treatments, and the use thereof as catalyst. These novel materials have dramatically increased external surface area by virtue of their framework with nano-scale thickness, and thus exhibit improved molecular diffusion, and thus have much higher activities as catalyst and ion exchange resin than conventional zeolites.Type: ApplicationFiled: June 11, 2010Publication date: June 28, 2012Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ryong Ryoo, Minkee Choi, Kyungku Na
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Patent number: 8203011Abstract: The present invention provides a 3?,4?,5-trimethoxy flavone derivative and a pharmaceutically acceptable salt thereof, preparation thereof, and a pharmaceutical composition for the treatment and prevention of dry eye syndrome comprising the same as an active ingredient. The 3?,4?,5-trimethoxy flavone derivative and its pharmaceutically acceptable salt inhibit corneal damage through excellent stimulatory action on mucus secretion in the conjunctiva and therefore may be effective as a prophylactic or therapeutic agent for dry eye syndrome.Type: GrantFiled: June 2, 2008Date of Patent: June 19, 2012Assignee: Dong-A Pharm. Co., Ltd.Inventors: Seul-Min Choi, Kyung-Koo Kang, Dong-Sung Kim, Jeong-Hoon Kim, Byoung-Ok Ahn, Moo-Hi Yoo, Mi-Jeong Seo, Ju-Mi Kim, Yong-Duck Kim, Sun-Woo Jang, Yong-Sung Shon
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Patent number: 8178702Abstract: A composition comprising compound of formula I, a process for preparing the composition comprising compound of formula I, methods of authentication for an article comprising compound of formula I or compound of formula II, authentication technology for polymer based articles comprising compound of formula I or formula II, methods of facilitating such authentication and method of making articles capable of authentication.Type: GrantFiled: May 16, 2008Date of Patent: May 15, 2012Assignee: Sabic Innovative Plastics IP B.V.Inventors: Yogendrasinh Chauhan, Mahesh Chaudhari, Adil Dhalla, Sriramakrishna Maruvada, Shantaram Naik, Vandita Pai-Paranjape, Philippe Schottland, Ganapati Shankarling, Kiran Puthamane, Meerakani Sait
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Patent number: 8178609Abstract: A method of treatment of mucopolysaccharidosis, the method including administering to a patient in the need of such treatment-a therapeutically effective amount of a natural isoflavone of formula (I), a derivative thereof, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition including a pharmaceutically acceptable excipient; and a natural isoflavone of formula (I), a derivative thereof, or a pharmaceutically acceptable salt thereof, the natural isoflavone, the derivative thereof, or the pharmaceutically acceptable salt threof being in a therapeutically effective amount for the treatment of mucopolysaccharidosis.Type: GrantFiled: September 21, 2006Date of Patent: May 15, 2012Assignee: Instytut FarmaceutycznyInventors: Grzegorz Grynkiewicz, Grzegorz Wegrzyn, Barbara Szechner, Wieslaw Szeja, Anna Tylki-Szymańska, Alicja Wegrzyn, Joanna Jakobkiewicz-Banecka, Sylwia Barańska, Barbara Czartoryska, Ewa Piotrowska
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Publication number: 20120115941Abstract: Compounds of formula I are disclosed which are useful as glycemic index lowering agents and/or, as ?-amylase and/or ?-glucosidase inhibitors. Also disclosed are nutritional and/or pharmaceutical compositions and supplements comprising one or more of these compounds. The compounds will be beneficial to patients who require stabilization of their postprandial glucose levels.Type: ApplicationFiled: April 16, 2010Publication date: May 10, 2012Applicant: SACRON INNOVATIONS PTY LIMITEDInventors: Dionne Nadine Payn, David Norman Leach, Myrna A. Deseo, Carole Ann Morris
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Publication number: 20120114639Abstract: We describe herein compositions and methods related to inferring with microbial infection. Generally, the compositions include an infection antagonist that inhibits formation of a heparin sulfonated proteoglycan (HSPG)-containing infection complex. Generally, the methods include administering to a subject an amount of a composition as described herein effective to inhibit infection by a microorganism that that infects a host through interactions that involve HSPG.Type: ApplicationFiled: November 4, 2011Publication date: May 10, 2012Inventors: MICHELLE ADAIR OZBUN, Zurab Surviladze
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Publication number: 20120101152Abstract: A method for producing 4?-demethylnobiletin or 4?-demethyltangeretin including fermenting a skin derived from at least one citrus fruit selected from citrus fruits belonging to section Acrumen in subgenus Metacitrus in genus Citrus or citrus fruits belonging to section Aurantium in subgenus Archicitrus in genus Citrus, or a water extract product thereof using one or more Aspergillus molds selected from Aspergillus kawachii, Aspergillus awamori, Aspergillus oryzae, Aspergillus sojae, Aspergillus saitoi, and Aspergillus usamii to obtain a fermented product.Type: ApplicationFiled: March 10, 2010Publication date: April 26, 2012Inventors: Shuichi Kusano, Hiroshi Tamura
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Publication number: 20120094336Abstract: Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.Type: ApplicationFiled: August 12, 2009Publication date: April 19, 2012Inventor: Bert Steffan
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Patent number: 8158810Abstract: Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.Type: GrantFiled: February 13, 2009Date of Patent: April 17, 2012Assignees: Gilead Sciences, Inc., The Endowment For Research in Human Biology, Inc.Inventors: Jeff Zablocki, Matthew Abelman, Michael Organ, Yaroslav Bilokin, Elfatih Elzein, Tetsuya Kobayashi, Rao Kalla, Thao Perry, Xiaofen Li, Robert Jiang, Ivan Diamond, Lina Yao, Peidong Fan, Maria Pia Arolfo, Zhan Jiang, Wing Ming Keung, Guoxin Tao
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Publication number: 20120083440Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.Type: ApplicationFiled: October 5, 2011Publication date: April 5, 2012Inventors: William M. Pierce, JR., K. Grant Taylor, Leonard C. Waite, Kevyn Merten
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Publication number: 20120077873Abstract: The present invention is directed to methods for reducing blood lactate concentration during exercise, physical activity or athletic performance.Type: ApplicationFiled: September 12, 2011Publication date: March 29, 2012Applicant: STOKELY-VAN CAMP, INC.Inventors: Jeffrey J. Zachwieja, Mark Arthur Pirner, JohnEric Smith
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Patent number: 8138165Abstract: Certain 2- and/or 3-substituted 5,6,7 substituted chromones are of use in treatment of treating diseases associated with overproduction of TNF-?, diseases associated with overproduction of superoxide anion radical And the treatment of organ damage. Some of the compounds are novel.Type: GrantFiled: October 22, 2003Date of Patent: March 20, 2012Assignee: Jenken Biosciences, Inc.Inventors: Mao-Hsiung Yen, Edwin S. C. Wu
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Publication number: 20120059176Abstract: Anti-inflammatory modalities are described with reference to select isoflavonoid compounds, compositions containing same and the use of said compounds and/or compositions in treatment, particularly for the treatment of inflammatory diseases and related conditions.Type: ApplicationFiled: November 11, 2011Publication date: March 8, 2012Applicant: MARSHALL EDWARDS, INC.Inventors: Catherine WALKER, Alan James HUSBAND, Michael John JAMES
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Publication number: 20120046353Abstract: The present invention relates to a Cleistocalyx operculatus-derived compound having inhibitory activity against neuraminidase and to a composition for preventing and treating diseases caused by avian and swine influenza viruses and novel influenza viruses, comprising the compound as an active ingredient.Type: ApplicationFiled: November 24, 2010Publication date: February 23, 2012Applicant: CHOONG ANG VACCINE LAB.Inventors: Injoong YOON, Eunhee KIM, Hwan-won CHOI, Won Keun OH, Trong Tuan DAO, Phuong Thien THUONG
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Publication number: 20120035253Abstract: The disclosure relates to new crystalline forms of genistein. The disclosed crystalline forms include crystalline genistein sodium salt dihydrate; crystalline genistein potassium salt dihydrate; crystalline genistein calcium salt; crystalline genistein magnesium salt; crystalline genistein L-lysine salt; crystalline genistein N-methylglucamine salt; crystalline genistein N-ethylglucamine salt; crystalline genistein diethylamine salt; and crystalline genistein monohydrate. The disclosure also relates to the novel genistein salts represented by these crystalline forms. Therapeutic compositions containing at least one of these crystalline forms of genistein and/or a genistein salt and a pharmaceutically acceptable carrier are described.Type: ApplicationFiled: December 11, 2009Publication date: February 9, 2012Inventors: Anders Berkenstam, Stefan Rehnmark, Michael-Robin Witt, Keith Lorimer, Stephen Watt
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Publication number: 20120029066Abstract: Novel Use of flavones having 2-phenylchromen-4-one skeleton is disclosed herein. The flavones are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient diagnosed with a psychiatric disorder with sensorimotor gating deficits.Type: ApplicationFiled: August 1, 2011Publication date: February 2, 2012Applicants: Taipei Medical University, National Taiwan UniversityInventors: Lih-Chu CHIOU, Wei-Jan HUANG
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Publication number: 20120022062Abstract: The present invention relates to flavanoid compounds of general formula (X1) wherein: R1 is selected from a group consisting of morpholinyl, N-methyl piperizinyl, piperidinyl and N,N?-dimethylamino groups, and n ranges from 3 to 6, and process for preparation thereof. The present invention relates to the demonstration of anti Helicobacter pylori activity and gastric antisecretory activity of semisynthetically designed flavonoid compounds, to be used for the prevention and treatment of gastroduodenal disorders in general and peptic ulcer diseases in particular. The present invention also relates to a hetero-dimeric bi-functional molecule that can be used as monotherapy substituting/replacing/overcoming currently used triple/quadruple therapy, thereby implicating/anticipating/envisaging its commercial applicability.Type: ApplicationFiled: February 26, 2010Publication date: January 26, 2012Inventors: Pratap Kumar Dab, Suchandra Goswami, Annalaskhmi Chinniah, Janaswamy Madusudana Rao, Suresh Babu Katragadda
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Patent number: 8101171Abstract: The identification of compounds, strigolactones, having the ability to stimulate the growth and/or development of arbuscular mycorrhizal fungi (AM fungi). Such compounds are, for example, the natural strigolactones strigol, alectrol, sorgolactone, orobanchol, or their synthetic analogs GR7, GR24, Nijmegen-1, demethylsorgolactone. New ways of developing an agriculture that is more respectful of the environment, and permits the implementation, on a small or large scale, of advanced mycorrhization techniques aimed at optimizing the production of fungic inoculum, the use of AM fungi in soils or cultivation substrates, and intensifying the symbiotic interaction between these microorganisms and cultivated plants.Type: GrantFiled: February 9, 2005Date of Patent: January 24, 2012Assignees: Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Guillaume Becard, Christophe Roux, Nathalie Sejalon-Delmas, Virginie Puech, Sébastien Roy
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Publication number: 20120003273Abstract: The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substitutedType: ApplicationFiled: May 14, 2009Publication date: January 5, 2012Inventors: Atul Goel, Amit Kumar, Sumit Chaurasia, Divya Singh, Abnish Kumar Gautam, Rashmi Pandey, Ritu Trivedi, Man Mohan Singh, Naibedya Chattopadhyay, Lakshmi Manickavasagam, Girish Kumar Jain, Anil Kumar Dwivedi
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Patent number: 8084628Abstract: Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.Type: GrantFiled: August 31, 2009Date of Patent: December 27, 2011Assignee: Marshall Edwards, Inc.Inventors: Andrew Heaton, Alan Husband
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Publication number: 20110301363Abstract: The invention relates to a method for carrying out an oxidation reaction for producing a product by heating a reaction medium containing a reactant and oxygen or an oxygen carrier in a reactor, wherein the reaction medium is brought into contact with a solid heating medium which may be heated by electromagnetic induction, which is surrounded by the reaction medium. The heating medium is heated by electromagnetic induction using an inductor, wherein an oxidation reaction is carried out on the first reactant to give a product and the product is separated from the heating medium. The inductor preferably generates an alternating field with a frequency in the range 1 to 100 kHz, preferably in the range 10 to 80 kHz and in particular up to 50 kHz.Type: ApplicationFiled: August 16, 2011Publication date: December 8, 2011Inventors: Carsten FRIESE, Andreas Kirschning, Sascha-Volkan Ceylan
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Patent number: 8067622Abstract: The present invention relates to an efficient method for producing naringenin derivatives from xanthohumol or derivatives thereof. In particular, the method according to the present invention provides the production of isoxanthohumol, for example also in enantiomer-enriched form, from xanthohumol and subsequent demethylation of isoxanthohumol according to specific procedures obtaining corresponding naringenin derivatives, such as, in particular, 8-prenylnaringenin.Type: GrantFiled: February 7, 2006Date of Patent: November 29, 2011Assignee: Hopsteiner-Hallertauer Hopfenveredelungsgesellschaft M.B.H.Inventors: Heike Wilhelm, Ludger A. Wessjohann, Martin Biendl