Chalcogen Of A -c(=x)x- Group, Wherein The X's Are The Same Or Diverse Chalcogens, Bonded Directly To The Carbocyclic Ring Of The Bicyclo Ring System (e.g., Tocopherol Esters, Etc.) Patents (Class 549/410)
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Patent number: 10874122Abstract: Provided are beverage compositions containing non-polar compounds that retain one or more organoleptic properties after formulation as compared to beverage compositions that do not contain the non-polar compounds. Also provided are methods for producing beverage compositions that contain non-polar compounds such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols and carotenoids; oil soluble vitamins; alpha lipoic acid; other oils; and coenzymes, including coenzyme Q10, and other oil-based additives.Type: GrantFiled: February 8, 2013Date of Patent: December 29, 2020Assignee: Virun, Inc.Inventor: Philip J. Bromley
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Patent number: 10668029Abstract: Provided herein are compositions and methods for preparing foods and beverages that contain additives, such as nutraceuticals, pharmaceuticals, and supplements, such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including Coenzyme Q10, and other oil-based additives.Type: GrantFiled: October 20, 2017Date of Patent: June 2, 2020Assignee: Virun, Inc.Inventor: Philip J. Bromley
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Patent number: 10220007Abstract: Provided herein are compositions and methods for preparing foods and beverages that contain additives, such as nutraceuticals, pharmaceuticals, and supplements, such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including Coenzyme Q10, and other oil-based additives.Type: GrantFiled: September 14, 2012Date of Patent: March 5, 2019Assignee: Virun, Inc.Inventor: Philip J. Bromley
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Patent number: 10213490Abstract: Compositions and methods for mucosal delivery of agents are provided. The compositions are intended for administration to mucosal surface, such as oral, gastrointestinal and nasal mucosa. The compositions provided contain one or more mucoadhesive proteins and an agent to be delivered. Methods for delivery of agents using the compositions provided herein are also provided.Type: GrantFiled: March 16, 2017Date of Patent: February 26, 2019Assignee: Virun, Inc.Inventors: Philip J. Bromley, Nurruzana Rahim, Koon Zee Lam
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Patent number: 10016363Abstract: Provided are compositions and methods for producing water-soluble powders that contain additives such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including coenzyme Q10, and other oil-based additives.Type: GrantFiled: September 25, 2015Date of Patent: July 10, 2018Assignee: Virun, Inc.Inventor: Philip J. Bromley
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Patent number: 9788564Abstract: Provided herein are compositions and methods for preparing foods and beverages that contain additives, such as nutraceuticals, pharmaceuticals, and supplements, such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including Coenzyme Q10, and other oil-based additives.Type: GrantFiled: May 7, 2014Date of Patent: October 17, 2017Assignee: Virun, Inc.Inventor: Philip J. Bromley
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Patent number: 9351517Abstract: Provided are compositions that contain water-soluble vitamin E derivative mixtures (compositions), such as tocopheryl polyethylene glycol succinate (TPGS), TPGS analogs, TPGS homologs and TPGS derivatives. The water-soluble vitamin E mixtures contain mixtures that include dimers and monomers of the vitamin E derivative, where the amount of dimer is greater than 12%, such as 29%, 35%, 50%, 60%, and the amount of monomer is less than 87%, by weight, of the water-soluble vitamin E derivative mixture. Also provided are products containing the water-soluble vitamin E derivative mixtures, including concentrates for dilution into aqueous beverages and compositions for direct ingestion.Type: GrantFiled: March 12, 2014Date of Patent: May 31, 2016Assignee: Virun, Inc.Inventor: Philip J. Bromley
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Patent number: 9320295Abstract: Provided are compositions and methods for clear and stable beverages that contain additives such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including Coenzyme Q10, and other oil-based additives.Type: GrantFiled: March 22, 2011Date of Patent: April 26, 2016Assignee: Virun, Inc.Inventor: Philip J. Bromley
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Publication number: 20140335157Abstract: The present invention relates to a compound represented by the formula (1) wherein Xa and Xb are each independently X1 or X2; s is 1 or 2, R4 is an alkyl group having 1-6 carbon atoms, na and nb are each independently 0 or 1, R1a and R1b are each independently an alkylene group having 1-6 carbon atoms, R2a and R2b are each independently an alkylene group having 1-6 carbon atoms, Ya and Yb are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, and R3a and R3b are each independently a sterol residue, a liposoluble vitamin residue or an aliphatic hydrocarbon group having 12-22 carbon atoms, and use thereof.Type: ApplicationFiled: May 16, 2014Publication date: November 13, 2014Inventors: Kota TANGE, Masaya ARAI, Kazuhiro KUBO, Hidetaka AKITA, Hideyoshi HARASHIMA, Hiroto HATAKEYAMA, Ryohei ISHIBA, Masami UKAWA, Hiroki TANAKA
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Publication number: 20140235536Abstract: A composition in the form of an injectable aqueous solution, the pH of which is from 6.6 to 7.8, comprises at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) an anionic compound bearing carboxylate charges and hydrophobic radicals. The composition may also include a prandial insulin.Type: ApplicationFiled: February 12, 2014Publication date: August 21, 2014Applicant: ADOCIAInventors: Olivier SOULA, Richard CHARVET, Alexandre GEISSLER
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Patent number: 8785665Abstract: In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.Type: GrantFiled: December 1, 2010Date of Patent: July 22, 2014Assignee: Mycell Technologies, LLCInventor: Volker Berl
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Patent number: 8546621Abstract: The present invention is directed to a process for the manufacture of 3,7-dimethyl-1-octen-3-ol comprising the following steps: a) hydrogenation of 6-methyl-5-hepten-2-on to 6-methyl-2-heptanon in the presence of hydrogen and a palladium containing catalyst on a carrier selected from the group consisting of carbon, calcium carbonate and aluminum oxide. b) reaction of 6-methyl-2-heptanon with acetylene to 3,7-dimethyl-1-octin-3-ol in the presence of ammonia and potassium hydroxide and in the absence of any additional organic solvent; c) hydrogenation of 3,7-dimethyl-1-octin-3-ol to 3,7-dimethyl-1-octen-3-ol in the presence of hydrogen and a palladium containing catalyst on a carrier selected from the group consisting of calcium carbonate, aluminum oxide, silica, porous glass, carbon or graphite, and barium sulphate, with the proviso that the catalyst additionally contains lead when the carrier is calcium carbonate.Type: GrantFiled: August 24, 2011Date of Patent: October 1, 2013Assignee: DSM IP Assets B.V.Inventors: Werner Bonrath, Johannes Tschumi, Jonathan Medlock
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Publication number: 20130211105Abstract: A method for acylating tertiary alcohols and phenolic compounds with carboxylic acids or their anhydrides in micro-reaction systems wherein the acylation is effected in the absence of any catalyst including water at residence times of at most 30 minutes.Type: ApplicationFiled: January 13, 2011Publication date: August 15, 2013Inventors: Werner Bonrath, Ingo Koschinski, Thomas Van Oordt
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Patent number: 8466134Abstract: The present invention provides compositions containing corticosteroid compounds as active agents for the treatment of ailments and diseases of the respiratory tract, particularly the lungs, by way of nasal and pulmonary administration. The corticosteroid compounds are present in a dissolved state in the compositions. The compositions can be formulated in a concentrated, essentially non-aqueous form for storage or in a diluted, aqueous-based form for ready delivery. In a preferred embodiment, the corticosteroid composition contains an ethoxylated derivative of vitamin E and/or a polyethylene glycol fatty acid ester as the high-HLB surfactant present in the formulation. The compositions are ideally suited for inhaled delivery with a nebulizer or for nasal delivery.Type: GrantFiled: June 24, 1999Date of Patent: June 18, 2013Assignee: Athena Neurosciences, Inc.Inventors: Zahir Saidi, Boris Klyashchitsky
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Publication number: 20130145962Abstract: Stabilizer compositions having a chroman-based compound according to Formula (V): and their use in processes for stabilizing organic materials subject to degradation and/or discoloration due to the effects from light, oxygen and heat, and in processes for producing articles from organic materials blended therewith, are provided herein.Type: ApplicationFiled: June 13, 2012Publication date: June 13, 2013Applicant: CYTEC TECHNOLOGY CORP.Inventors: Ram GUPTA, Sari-Beth SAMUELS, J. Mon Hei ENG, Thomas STEELE
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Publication number: 20130096209Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.Type: ApplicationFiled: April 15, 2011Publication date: April 18, 2013Applicants: Kraft Foods Global Brands LLC, Chromocell CorporationInventors: David Hayashi, William P. Jones, Jane V. Leland, Peter H. Brown, Joseph Gunnet, Daniel Lavery, Louise Slade, Kambiz Shekdar, Jessica Langer
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Patent number: 8299277Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.Type: GrantFiled: November 14, 2007Date of Patent: October 30, 2012Assignees: National Institute of Radiological Sciences, Fukuoka UniversityInventors: Kazunori Anzai, Megumi Ueno, Haruko Yakumaru, Junichi Ueda, Makoto Akashi, Shizuko Kobayashi, Jiro Takata, Nobuo Ikota
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Publication number: 20120136048Abstract: A method for preventing, reducing, ameliorating or treating ophthalmic disorders associated with neurodegenerative diseases or trauma, comprising the topical, periocular, or intraocular application of an ophthalmic formulation comprising a therapeutically effective amount of one or more ophthalmic agents selected from the group consisting of alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, delta-tocotrienol, or esters or mixtures thereof is disclosed. Use of tocotrienols for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are, or that are associated with, mitochondrial diseases is also discussed. Topical ophthalmic formulations comprising tocotrienols are also discussed.Type: ApplicationFiled: April 27, 2010Publication date: May 31, 2012Inventors: Guy M. Miller, William D. Shrader, Viktoria Kheifets
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Publication number: 20120129818Abstract: Ortho methoxy phenolic compounds are provided that include methylenedioxyphenyl ferulate and ferulylproline and derivatives thereof. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease, angina, stroke, and myocardial infarction, are further provided. The compounds are also useful in reducing low-density lipoprotein oxidation, improving or increasing vasodilation, and reducing plaque destabilization in a subject.Type: ApplicationFiled: April 23, 2010Publication date: May 24, 2012Inventor: Desikan Rajagopal
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Patent number: 8183396Abstract: The invention relates to a process for the working-up of a vitamin E (VE)- and/or vitamin E acetate (VEA)-containing product stream, which is substantially characterized by purification of a vitamin E-containing product stream, acetylation of at least a part of the purified vitamin E and purification of at least a part of the acetylated vitamin E, the purification of vitamin E and vitamin E acetate preferably being effected by distillation, for example rectification.Type: GrantFiled: August 19, 2005Date of Patent: May 22, 2012Assignee: DSM IP Assets B.V.Inventors: Werner Pietzonka, Peter Ruckstuhl, Angela Wildermann
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Publication number: 20120053353Abstract: The present invention is directed to a process for the manufacture of 3,7-dimethyl-1-octen-3-ol comprising the following steps: a) hydrogenation of 6-methyl-5-hepten-2-on to 6-methyl-2-heptanon in the presence of hydrogen and a palladium containing catalyst on a carrier selected from the group consisting of carbon, calcium carbonate and aluminum oxide. b) reaction of 6-methyl-2-heptanon with acetylene to 3,7-dimethyl-1-octin-3-ol in the presence of ammonia and potassium hydroxide and in the absence of any additional organic solvent; c) hydrogenation of 3,7-dimethyl-1-octin-3-ol to 3,7-dimethyl-1-octen-3-ol in the presence of hydrogen and a palladium containing catalyst on a carrier selected from the group consisting of calcium carbonate, aluminum oxide, silica, porous glass, carbon or graphite, and barium sulphate, with the proviso that the catalyst additionally contains lead when the carrier is calcium carbonate.Type: ApplicationFiled: August 24, 2011Publication date: March 1, 2012Applicant: DSM IP ASSETS B.V.Inventors: Werner BONRATH, Johannes Tschumi, Jonathan Medlock
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Patent number: 8044097Abstract: The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondria) disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: GrantFiled: February 26, 2009Date of Patent: October 25, 2011Assignee: Ampere Life Sciences, Inc.Inventors: Bing Wang, Jian Chen
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Publication number: 20110184194Abstract: Disclosed herein are environmentally benign surfactants including TPGS-550-M, TPGS-750-M and TPGS-1000-M that comprises of diesters composed of racemic ?-tocopherol, MPEG-550, MPEG-750 and MPEG-1000, respectively, and a succinic acid fragment. Also disclosed are novel and efficient methods for their synthesis. The surfactants are designed as an effective nanomicelle-forming species for dissolution of hydrophobic compounds and composition and for general use in metal-catalyzed cross-coupling reactions in water.Type: ApplicationFiled: January 17, 2011Publication date: July 28, 2011Inventor: Volker Berl
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Publication number: 20110144358Abstract: The present invention is directed to a process for the manufacture of a 2,3,5-trimethylhydroquinone dialkanoate comprising reacting ketoisophorone with an acylating agent in the presence of an indium salt as the catalyst. Preferred are indium(III) salts such as indium trichloride or indium tris (trifluoromethanesulfonate). Further aspects of the present invention are a process for the manufacture of 2,3,5-trimethylhydroquinone using 2,3,5-trimethylhydroquinone dialkanoate as the starting material, especially a process for the manufacture of 2,3,5-trimethylhydroquinone by transesterification of 2,3,5-trimethylhydroquinone dialkanoate, as well as a process for the manufacture of a-tocopherol and its alkanoates, especially of (all-rac)-a-tocopherol and its acetate, comprising the reaction of ketoisophorone to 2,3,5-trimethylhydroquinone dialkanoate according to the present invention.Type: ApplicationFiled: February 18, 2011Publication date: June 16, 2011Applicant: DSM IP Assets B.V.Inventors: Werner Bonrath, Yann Foricher
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Patent number: 7872127Abstract: The invention is directed to substituted 2-aminoacetamides represented by formula (II): and to pharmaceutically acceptable salts and prodrugs thereof, wherein the substituents are defined herein. The invention is also directed to the use of substituted 2-aminoacetamides in methods for the treatment of neuronal damage following global and focal ischemia, and for the treatment, prevention or amelioration of pain, as anticonvulsants, as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.Type: GrantFiled: May 28, 2009Date of Patent: January 18, 2011Assignee: Purdue Neuroscience CompanyInventors: Nancy C. Lan, Yan Wang, Sui Xiong Cai
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Publication number: 20100273871Abstract: Compounds of formula I: wherein X is selected from oxygen, nitrogen and sulfur; n is 0 or 1; R1 is selected from alkyl, carboxylic acid, carboxylate, carboxamide, ester and combinations thereof; R2 is selected from alkyl, substituted alkyl, carboxylic acid, carboxylate, carboxamide, sulfonyl, sulfonamide and combinations thereof; and derivatives and metabolites thereof. Further provided are methods of using a compound of formula I to prevent and/or treat a subject having a condition characterized by unwanted cell proliferation. Also provided are pharmaceutical compounds comprising one or more compounds of formula I, or derivatives or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 27, 2010Publication date: October 28, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang
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Patent number: 7803955Abstract: The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble ?-tocopherol metabolite known under the name of ?-CEHC, which is prepared by the acid-catalyzed reaction of condensation of trimethyl hydroquinone with linalool in boiling octane, using n-toluenesulfonic acid or (+)-camphor-10-sulfonic acid as the catalyst. The reaction is carried out for 3 hours at the trimethyl hydroquinone:linalool:catalyst mole ratio of 1:1:0.1. The forming product is acetylated with acetic anhydride in pyridine at room temperature for 0.5 hour, and then ozonized in acetone in the presence of Ba(OH)2, oxidized with Jones' reagent in acetone, and isolated on silica gel column chromatography. Said compound is an acetate derivative of the main ?-tocopherol metabolite—?-CEHC, for which high efficiency has been noted in treating disorders of the central nervous system.Type: GrantFiled: June 15, 2006Date of Patent: September 28, 2010Assignee: Institut Neftekhimii I Kataliza RanInventors: Anna Yulievna Spivak, Viktor Nikolaevich Odinokov, Oxana Valerievna Knyshenko
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Publication number: 20100168045Abstract: The invention concerns novel polyunsaturated compounds of formula (I) wherein: R1 represents a R?1, -A-R?1 group, R?1 being selected from —COOH, —COOR3, —CONH2, —CONHR3, —CONR3, R4, —CHO, —CH2OH, —CH2OR5, and A represents a C2-C16 alkylene, alkenylene or alkynylene; R2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC—(CH2)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R?2—O—R6 group, wherein R?2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R6 represents a hydrogen atom, a straight or branched optionally substituted C1-C16 alkyl, a straight or branched optionally substituted C2-C16 alkenyl, or a straight or branched C2-C16 alkynyl group, an optionally substituted tocopheryType: ApplicationFiled: December 14, 2006Publication date: July 1, 2010Applicant: Pierre Fabre Dermo-CosmetiqueInventors: Pascal Bordat, Roger Tarroux, Jean-Hilaire Saurat, Olivier Sorg, Jean-Louis Brayer, Natacha Frison
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Patent number: 7683024Abstract: The invention concerns novel biodegradable polyaminoacid materials, useful in particular for vectoring active principle(s). The invention also concerns novel pharmaceutical, cosmetic dietetic or phytosanitary compositions based on said polyaminoacids. The invention aims at providing a novel polymer raw material, capable of being used for vectoring active principles and enabling optimal fulfillment of all specified requirements: biocompatibility, biodegradability, easy and inexpensive transformation into particles vectoring active principles, the particles being themselves capable of forming colloidal suspensions, of being easily associated with numerous active principles, and of releasing said active principles in vivo.Type: GrantFiled: June 3, 2003Date of Patent: March 23, 2010Assignee: Flamel TechnologiesInventors: You-Ping Chan, Stéphanie Angot, Olivier Breyne
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Publication number: 20090287002Abstract: The invention relates to a process for the working-up of a vitamin E (VE)- and/or vitamin E acetate (VEA)-containing product stream, which is substantially characterized by purification of a vitamin E-containing product stream, acetylation of at least a part of the purified vitamin E and purification of at least a part of the acetylated vitamin E, the purification of vitamin E and vitamin E acetate preferably being effected by distillation, for example rectification.Type: ApplicationFiled: August 19, 2005Publication date: November 19, 2009Inventors: Werner Pietzonka, Peter Ruckstuhl, Angela Wildermann
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Publication number: 20090240070Abstract: Disclosed is a dermatological preparation that are safe and are excellent in inhibiting and removing skin pigmentation and in inhibiting skin roughness. A dermatological preparation comprising a tocopherol aminoalkylcarboxylate and/or a salt thereof, the tocopherol aminoalkylcarboxylate being represented by Formula (I): wherein R1 is a hydrogen atom or a lower alkyl group; R2 and R3 are each independently a hydrogen atom or a methyl group; X is a cycloalkylene group of 3 to 6 carbon atoms; and n is 0 or 1.Type: ApplicationFiled: February 5, 2007Publication date: September 24, 2009Applicant: SHOWA DENKO K.K.Inventors: Harumi Kamachi, Hirobumi Aoki, Yohei Kurata, Jiro Takata
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Patent number: 7588778Abstract: The present invention relates to a delivery carrier including liposomes or nanoparticles for targeting the cells expressed with somatostatin receptor, consisting of a plurality of liposomes that have one phospholipid bilayer coating, one hydrophilic core and a bioactive substance. The bioactive substance is packaged in the hydrophilic core, or embedded in the phospholipid bilayer, or electrically bound with liposomes as a complex, wherein the phospholipid bilayer coating is conjugated with a plurality of molecules in the outer surface. The molecules recognize the somatostatin receptor in the surface of the target cells and induce receptor-mediated endocytosis.Type: GrantFiled: December 30, 2003Date of Patent: September 15, 2009Assignee: Industrial Technology Research InstituteInventors: Pei Kan, Ae-June Wang
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Patent number: 7514461Abstract: The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: GrantFiled: September 15, 2004Date of Patent: April 7, 2009Assignee: Edison Pharmaceuticals, Inc.Inventors: Bing Wang, Gail Walkinshaw, Sekhar Boddupalli, Arkadij M. Elizarov, Xianming Jin, Xianfeng Li, Donald R. James, Jiangao Song, Jian Chen, Wei Zhang
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Publication number: 20080305101Abstract: Disclosed are compositions and methods related to clot binding compounds. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.Type: ApplicationFiled: December 31, 2007Publication date: December 11, 2008Inventors: Erkki Ruoslahti, Dmitri Simberg
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Patent number: 7435836Abstract: The present invention relates to a process for the manufacture of a tocopheryl acylate which comprises reacting a tocopherol with an acylating agent in the presence of a solid basic catalyst comprising, an alkali metal and/or alkaline earth metal preferably on a solid carrier and to the use of such catalysts in the acylation of tocopherols.Type: GrantFiled: April 18, 2005Date of Patent: October 14, 2008Assignee: DSM IP Assets B.V.Inventors: Werner Bonrath, Lisa Giraudi Bijasson
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Publication number: 20080146823Abstract: A process for producing odor free tocopherol acetate is disclosed. This process comprises forming a solution of tocopherol acetate in a suitable solvent, e.g., isopropyl alcohol, subjecting said solution to a sufficient amount of low pressure and heat to remove said solvent and sparging sufficient amount of an inert gas through said solution to remove traces of remaining solvent.Type: ApplicationFiled: February 20, 2008Publication date: June 19, 2008Inventors: Madhu V. Kulkarni, George R. Martin
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Patent number: 7384558Abstract: Therapeutic compositions are provided. The compositions include a single molecule that can display both antioxidant and carbonyl trapping properties. This can effectively reduce inflammation, oxidative stress and carbonyl stress, such as to prevent and/or treat cardiovascular disease and inflammatory diseases in kidney disease patients.Type: GrantFiled: July 26, 2004Date of Patent: June 10, 2008Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Ton That Hai, Mark Nordhaus, Paul Sanders, Cong Jiang, Sujatha Karoor, Ben Melnick, Leo Martis
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Patent number: 7342121Abstract: A process is described for making high density tocopherol succinate powder. In this process, a solution of tocopherol succinate is prepared in hexane. The hexane is removed under heat and pressure. The resulting powder is then mixed with hexane yielding larger particles and a denser product. In the process, an atmosphere enriched in nitrogen is maintained over said tocopherol powder during said process.Type: GrantFiled: January 27, 2006Date of Patent: March 11, 2008Assignee: Cognis CorporationInventor: Madhu V. Kulkarni
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Patent number: 7161055Abstract: A process for the separation and recovery of minor components from vegetable oil such as palm oil. Esterified palm oil is subjected to molecular distillation giving a concentrate rich in minor components. The concentrate is then adsorbed to adsorbents such as normal phase silica gel, reversed phase (particularly C18) silica gel or neutral alumina as well as polymer absorbents such as polyethylene glycol and polyacrylate polyalcohol. Minor components such as squalene, carotenes, tocols and sterols are then selectively desorbed, separated and recovered using solvents operating at isocratic conditions. The desorption of the said minor components are sped up by applying pressure of between 0.2 to 50 bar. By the same method, individual tocols isomers from palm oil can also be separated and recovered.Type: GrantFiled: November 25, 2003Date of Patent: January 9, 2007Assignee: Malaysian Palm Oil BoardInventors: Yuen May Choo, Mei Han Ng, Ah Ngan Ma, Yusof Basiron
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Patent number: 7084172Abstract: The invention concerns a bioprecursor of formula (I), wherein A1 and A2 represent independently of each other a radical derived from a molecule capable of being used in dermatology or in cosmetology; X and Y represent independently of each other a hydrogen atom, a hydroxy group or a C1–C20 alkyl group; and n represents an integer between 0 and 10Type: GrantFiled: September 16, 2002Date of Patent: August 1, 2006Assignees: Pierre Fabre Dermo-Cosmetique, Universite Paul Sabatier ToulouseInventors: Daniel Redoules, Pascal Bordat, Jean-Jacques Perie
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Patent number: 6930191Abstract: Methods for preparing salts of tocopherol dibasic acid hemiesters in supercritical media are described.Type: GrantFiled: October 8, 2003Date of Patent: August 16, 2005Assignee: Cognis CorporationInventor: Jianhua Mao
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Publication number: 20040236098Abstract: The invention concerns a bioprecursor of formula (I), wherein A1 and A2 represent independently of each other a radical derived from a molecule capable of being used in dermatology or in cosmetology; X and Y represent independently of each other a hydrogen atom, a hydroxy group or a C1-C20 alkyl group; and n represents an integer between 0 and 10.Type: ApplicationFiled: March 16, 2004Publication date: November 25, 2004Inventors: Daniel Redoules, Pascal Bordat, Jean-Jacques Perie
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Patent number: 6790967Abstract: The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of trimethylhydroquinone and isophytol.Type: GrantFiled: December 19, 2002Date of Patent: September 14, 2004Assignee: Adisseo France S.A.S.Inventors: Jildaz Dhainaut, Thierry Durand
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Patent number: 6784303Abstract: A process is described for continuously preparing chromanol ester derivatives, in particular for continuously preparing carboxylic esters of tocopherols and tocotrienols by continuous acylation with carboxylic acids or carboxylic anhydrides.Type: GrantFiled: May 12, 2003Date of Patent: August 31, 2004Assignee: BASF AktiengesellschaftInventors: Carsten Oost, Gerd Kaibel, Harald Laas, Peter Schmitt, Jens von Erden
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Patent number: 6770672Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.Type: GrantFiled: February 11, 2000Date of Patent: August 3, 2004Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Laurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Publication number: 20040138478Abstract: Methods for preparing salts of tocopherol dibasic acid hemiesters in supercritical media are described.Type: ApplicationFiled: October 8, 2003Publication date: July 15, 2004Inventor: Jianhua Mao
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Patent number: 6716873Abstract: Disclosed are novel tocopherol ester compounds having the formula wherein X is a chain of 2 or 3 carbon atoms, e.g., ethylene and trimethylene, joining the 2 carbonyl groups to which they are bonded; and R1 is a group having the formula —Y—R4 wherein Y is a selenium, tellurium or sulfur atom and R4 is an alkyl, cycloalkyl or aryl radical. The tocopherol ester compounds of formula (I) exhibit antiproliferative and growth inhibitory effects on breast cancer cell lines.Type: GrantFiled: March 20, 2003Date of Patent: April 6, 2004Assignee: Yasoo Health Inc.Inventors: Anastasios Keramidas, Andreani Odysseos, Andreas Michael Papas
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Patent number: 6703384Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: GrantFiled: November 5, 2001Date of Patent: March 9, 2004Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Patent number: 6696413Abstract: The invention relates to a pharmaceutical preparation which consists of or contains cyclosporin A, an emulsifying &agr;-tocopherol derivative, an ethoxylation product of vegetable oils, fatty acids or fats as a further emulsifier and a pharmaceutically customary alcohol.Type: GrantFiled: December 3, 1998Date of Patent: February 24, 2004Assignee: Hexal AGInventors: Wilfried Fischer, Karin Klokkers
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Patent number: 6683194Abstract: Tocopherol derivatives are provided. In one embodiment, the tocopherol derivative includes a tocopherol moiety covalently coupled to branched hydrophilic moiety. In another embodiment, the tocopherol derivative includes a first tocopherol moiety covalently coupled to a second tocopherol moiety through a hydrophilic moiety. In other embodiments, the derivative includes three or more tocopherol moieties.Type: GrantFiled: February 5, 2002Date of Patent: January 27, 2004Assignee: Sonus Pharmaceuticals, Inc.Inventors: Yuehua Zhang, Manjari Lal, Nagesh Palepu