Plural Chalcogens Bonded Directly To The Hetero Ring Patents (Class 549/417)
  • Patent number: 10815210
    Abstract: The present invention is directed to benzocyclobutane derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity. More particularly, the compounds of the present invention are useful in the treatment of for example, Type II diabetes mellitus, Syndrome X, and complications and symptoms associated with said disorders.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 27, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Micheal Gaul, Gee-Hong Kuo, Guozhang Xu, Yin Liang
  • Patent number: 10759772
    Abstract: The present invention relates to a process For the preparation of Dapagliflozin DL-Proline co-crystal and its use in the preparation/purification of Dapagliflozin. The invention also provides a process for the preparation of Dapagliflozin (R,S)-1.2-propanediol monohydrate.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: September 1, 2020
    Assignee: Aurobindo Pharma Ltd
    Inventors: Senthilkumar Natrajan, Kishore Karumanchi, Vittal Tangirala, Sivakumaran Meenakshisunderam
  • Patent number: 10544180
    Abstract: Some embodiments relate to a novel process for preparing compositions including alkyl(alkyl-glucoside)uronates, from biobased or biocompatible/biodegradable raw materials, and also salts and acids thereof.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: January 28, 2020
    Assignee: ÉCOLE NATIONALE SUPÉRIEURE DE CHIMIE
    Inventors: Thierry Benvegnu, Freddy Pessel, Maud Benoît, Yves Lelong
  • Patent number: 10155738
    Abstract: A method is disclosed for synthesizing a compound that includes gallotannins from a part of a maple tree, into new skin whitening compounds. The method includes the step of isolating the gallotannin from the part of the maple tree.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: December 18, 2018
    Assignee: University of Rhode Island
    Inventors: Navindra Seeram, Hang Ma, Keykavous Parang
  • Patent number: 9335633
    Abstract: A positive resist composition is provided comprising a polymer comprising recurring units having a carboxyl or phenolic hydroxyl group substituted with an acid labile group and recurring units of 4-pyrone ester, and having a Mw of 1,000-500,000. The resist composition has a satisfactory effect of suppressing acid diffusion and a high resolution, and forms a pattern of good profile and minimal edge roughness after exposure.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: May 10, 2016
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Koji Hasegawa, Masayoshi Sagehashi
  • Patent number: 9271908
    Abstract: The present invention is directed to compositions comprising water, at least one biosurfactant and at least one fatty acid, which are characterized in that the fraction of the sum of all surfactants in the composition is from 1 to 30% by weight, and that the fraction of fatty acid, based on the sum of fatty acid and surfactants, is from 0.1 to 20% by weight, and to the use thereof as or for producing bath additives, shower gel, shampoos, conditioners, body cleansers or skin cleansers.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: March 1, 2016
    Assignee: EVONIK INDUSTRIES AG
    Inventors: Petra Allef, Christian Hartung, Martin Schilling
  • Patent number: 9040635
    Abstract: A polymer, optionally made from renewable sources, comprising a specific chemical structure that is a result of the polymerization of ?-hydroxycarbonyl compounds (alpha-hydroxycarbonyl compounds), particularly ?-hydroxyaldehydes (alpha-hydroxyaldehydes) and ?-hydroxyketones (alpha-hydroxyketones), or glycolaldehyde. A method of polymerization, the method comprising the step of reacting trimethylsilyl trifluoromethanesulfonate with the cyclic dimer of one or more ?-hydroxycarbonyl compounds. A method of making said polymer, the method comprising dehydrating a cyclic dimer of one or more ?-hydroxycarbonyl compounds. An end-capped polymer made from one or more ?-hydroxycarbonyl compounds and terminal end-cap groups.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: May 26, 2015
    Assignee: TDA Research, Inc.
    Inventors: Silvia DeVito Luebben, James William Raebiger, Aaron Jeremy Skaggs
  • Publication number: 20150140610
    Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 21, 2015
    Inventors: Adrian Ortiz, Tamas Benkovics, Zhongping Shi, Prashant P. Deshpande, Zhiwei Guo, David R. Kronenthal, Chris Sfouggatakis
  • Patent number: 9006429
    Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: April 14, 2015
    Assignee: Syngenta Crop Protection, LLC
    Inventors: Christopher John Mathews, James Nicholas Scutt, Michel Muehlebach
  • Publication number: 20150087031
    Abstract: The present invention relates to methods of processing lignocellulosic material to obtain hemicellulose sugars, cellulose sugars, lignin, cellulose and other high-value products. Also provided are hemicellulose sugars, cellulose sugars, lignin, cellulose, and other high-value products.
    Type: Application
    Filed: May 3, 2013
    Publication date: March 26, 2015
    Inventors: Robert Jansen, Claire Gregoire, philip Travisano, Lee Madsen, Neta Matis, Yael Har-Tal, Shay Eliahu, James Alan Lawson, Noa Lapidot, Luke Burke, Aharon M. Eyal, Timothy Allen Bauer, Hagit Sade, Paul Mcwilliams, Ziv-Vladimir Belman, Bassem Hallac, Michael Zviely, Yelena Gershinksy, Adam Carden
  • Patent number: 8987323
    Abstract: Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: March 24, 2015
    Assignee: Theracos, Inc.
    Inventors: Mengzhuang Cai, Qian Liu, Ge Xu, Binhua Lv, Brian Seed, Jacques Y. Roberge
  • Publication number: 20150080588
    Abstract: The present invention comprises processes for preparing compounds of Formula (I). wherein: R0, R1, R2, R3, R4, R5, and A are as defined in the specification.
    Type: Application
    Filed: July 24, 2014
    Publication date: March 19, 2015
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Shawn Branum, Michael Reuman, Ronald K. Russell, Christopher A. Teleha
  • Patent number: 8956999
    Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds of formula (I), which are suitable for use as herbicides.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: February 17, 2015
    Assignees: Syngenta Limited, Syngenta Crop Protection LLC
    Inventors: Stephane André Marie Jeanmart, Christopher John Mathews, John Benjamin Taylor, Mangala Govenkar, Stephen Christopher Smith
  • Publication number: 20150031876
    Abstract: The present invention provides a pyrone derivative and a pyridone derivative, which are novel intermediates for synthesizing an anti-influenza drug, a method of producing the same, and a method of using the same.
    Type: Application
    Filed: September 5, 2014
    Publication date: January 29, 2015
    Applicant: Shionogi & Co., Ltd.
    Inventors: Yukihito Sumino, Kazuya Okamoto, Moriyasu Masui, Toshiyuki Akiyama
  • Patent number: 8933251
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: January 13, 2015
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Satoshi Shinachi, Takeshi Kinsho, Koji Hasegawa, Yuji Harada, Jun Hatakeyama, Kazunori Maeda, Tomohiro Kobayashi
  • Publication number: 20140378305
    Abstract: Compounds of formula wherein the substituents are as defined in claim 1, and related compositions, methods of use and processes of preparation.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Applicant: SYNGENTA LIMITED
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20140378540
    Abstract: The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).
    Type: Application
    Filed: September 12, 2012
    Publication date: December 25, 2014
    Inventors: Rajesh Jain, Sanjay Trehan, Jagattaran Das, Gurmeet Kaur Nanda, Sastry V. R. S Thungathurthi, Nishan Singh, Sudhir Kumar Sharma
  • Publication number: 20140356625
    Abstract: The present invention provides methods for manufacturing neuraminic acid derivatives. [Means for solution] Methods for manufacturing compounds represented by the formula (I): [wherein R1 represents a C1-C19 alkyl group], or a pharmacologically acceptable salt thereof, using N-acetylneuraminic acid dihydrate as a starting raw material are provided.
    Type: Application
    Filed: December 13, 2012
    Publication date: December 4, 2014
    Inventors: Tomohito Sakurai, Takumi Nakajima, Masakazu Wakayama, Fumihiko Toriyama, Yasuhisa Kuwahara
  • Publication number: 20140323746
    Abstract: A method is disclosed for recovering anhydrosugar alcohols from a mixture comprising closely related compounds, such as sugar alcohols. In the method the mixture is contacted with an adsorbent, whereby the anhydrosugar alcohols are selectively adsorbed. The anhydrosugar alcohols can be recovered by desorption from the adsorbent, using a desorbing solvent.
    Type: Application
    Filed: July 15, 2014
    Publication date: October 30, 2014
    Inventors: Johan VAN DEN BERGH, Jacob Adriaan MOULIJN
  • Patent number: 8865623
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: October 21, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20140256961
    Abstract: The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the delivery of compounds for the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Applicants: Shionogi & Co., Ltd., VïïV Healthcare Company
    Inventors: Brian Alvin JOHNS, Jason Gordon WEATHERHEAD, Toshikazu HAKOGI, Yasunori AOYAMA
  • Publication number: 20140179723
    Abstract: Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear and methods for preventing damage to or treating damage of auditory neurons and/or hair cells of the cochlea following acoustic or toxic insult.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 26, 2014
    Inventors: Donna S. Whitlon, Claus-Peter Richter
  • Patent number: 8748483
    Abstract: The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: June 10, 2014
    Assignee: SANOFI
    Inventors: Harm Brummerhop, Siegfried Stengelin, Hubert Heuer, Susanne Kilp, Andreas Herling, Thomas Klabunde, Dieter Kadereit, Matthias Urmann
  • Patent number: 8742139
    Abstract: Phenyliodonium ylide derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are shown for use as precursors in aromatic nucleophilic substitution reactions. The iodonium ylide group is substituted by nucleophiles such as halide ions to provide the corresponding haloaryl derivatives. No-carrier-added [F-18]fluoride ion exclusively substitutes the iodonium ylide moiety in these derivatives and provides high specific activity F-18 labeled fluoro derivatives. Protected L-dopa-6-iodonium ylide derivative have been synthesized as a precursors for the preparation of no-carrier-added 6-[F-18]fluoro-L-dopa. The iodonium ylide group in this L-dopa.derivative is nucleophilically substituted by no-carrier-added [F-18]fluoride ion to provide a [F-18]fluoro intermediates which upon acid hydrolysis yielded 6-[F-18]fluoro-L-dopa.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: June 3, 2014
    Assignee: The Regents of The University of California
    Inventors: Nagichettiar Satyamurthy, Jorge R. Barrio
  • Publication number: 20140135508
    Abstract: The present disclosure relates to compounds of formula I wherein the substituents are as defined in claim 1. The compounds are suitable intermediates in the preparation of herbicidally active 4-phenyl-3,5-pyrandiones, 4-phenyl-3,5-thiopyrandiones and 6-phenylcyclohexane-1,3,5-triones.
    Type: Application
    Filed: January 17, 2014
    Publication date: May 15, 2014
    Applicant: SYNGENTA LIMITED
    Inventor: James Nicholas SCUTT
  • Patent number: 8710249
    Abstract: Novel processes and intermediates are provided according to the general reaction scheme: Formula I, II, III, IV (I), (II), (III), (IV) utilizing a ruthenium catalyst in an oxidative cleavage of the triene 4 whereby an aldehyde may be produced and optionally taken on to a carboxylic acid 5: Formula V (V)
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: April 29, 2014
    Assignee: Shionogi & Co., Ltd.
    Inventor: Yasunori Aoyama
  • Publication number: 20140088079
    Abstract: The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.
    Type: Application
    Filed: June 1, 2012
    Publication date: March 27, 2014
    Applicant: GREEN CROSS CORPORATION
    Inventors: Soongyu Choi, Kwang Seop Song, Suk Ho Lee, Min Ju Kim, Hee Jeong Seo, Eun-Jung Park, Younggyu Kong, So Ok Park, Hyunku Kang, Myung Eun Jung, Kinam Lee, Hyun Jung Kim, Jun Sung Lee, Min Woo Lee, Mi-Soon KIM, Dong Ho Hong, Misuk Kang
  • Patent number: 8680012
    Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: March 25, 2014
    Assignee: Syngenta Crop Protection LLC
    Inventors: Christopher John Mathews, James Nicholas Scutt, Michel Muehlebach
  • Publication number: 20140039207
    Abstract: The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the delivery of compounds for the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Application
    Filed: October 2, 2013
    Publication date: February 6, 2014
    Applicants: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Brian Alvin JOHNS, Jason Gordon WEATHERHEAD, Toshikazu HAKOGI, Yasunori AOYAMA
  • Publication number: 20140005181
    Abstract: The present disclosure relates to compounds and methods for treating a disease mediated by apelin.
    Type: Application
    Filed: June 20, 2013
    Publication date: January 2, 2014
    Applicant: Sanford-Burnham Medical Research Institute
    Inventors: Layton Smith, Anthony B. Pinkerton
  • Publication number: 20140005389
    Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.
    Type: Application
    Filed: August 30, 2013
    Publication date: January 2, 2014
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John MATHEWS, James Nicholas SCUTT, Michel MUEHLEBACH
  • Patent number: 8603989
    Abstract: Methods are provided for treating and/or preventing kidney stones, employing an SGLT2 inhibitor alone, or in combination with a supply of carbohydrate, and/or in combination with a diuretic agent. Additionally, compositions comprising an SGLT2 inhibitor, optionally with a supply of carbohydrate, and/or a combination of an SGLT2 inhibitor and a diuretic agent are provided in the instant invention and are provided for use in the inventive methods.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: December 10, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventor: Mitchell Halperin
  • Publication number: 20130310332
    Abstract: The present document describes a neutraceutical, cosmeceuticals, functional food, pharmaceutical, food ingredient, and non-food ingredient compositions comprising sugar maple extract, essential oil compositions comprising oil extracted from an Acer tree, sweetening compositions containing sugar extracted from maple tree leaves, food ingredients comprising maple tree extract, cosmetic composition comprising maple tree extracts, infusion compositions prepared from maple tree leaves, maple roots, maple wood, maple stems of leaves and samara, and stems/twigs as well as compounds isolated from sugar maple biomass and the methods of extracting the same.
    Type: Application
    Filed: October 14, 2011
    Publication date: November 21, 2013
    Applicants: UNIVERSITY OF RHODE ISLAND, FEDERATION DES PRODUCTEURS ACERICOLES DU QUEBEC
    Inventors: Julie Barbeau, Genevieve Beland, Navindra P. Seeram, Tao Yuan
  • Patent number: 8569520
    Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: October 29, 2013
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masatoshi Murakata, Takuma Ikeda, Nobuaki Kimura, Akira Kawase, Masahiro Nagase, Keisuke Yamamoto
  • Publication number: 20130281393
    Abstract: The present invention provides novel and advantageous materials and methods for preventing and treating viral infection.
    Type: Application
    Filed: April 16, 2013
    Publication date: October 24, 2013
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SIK YIN LAU, LAI HUNG CINDY YANG
  • Patent number: 8551914
    Abstract: Molecules having the following structure are disclosed. Processes of using such molecules are disclosed.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: October 8, 2013
    Assignee: Dow AgroSciences, LLC.
    Inventors: Lawrence C. Creemer, Gary D. Crouse, Thomas C. Sparks, CaSandra Lee McLeod
  • Publication number: 20130231491
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Application
    Filed: March 20, 2013
    Publication date: September 5, 2013
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Shin-Etsu Chemical Co., Ltd.
  • Patent number: 8445704
    Abstract: A process is disclosed for converting polysaccharides to platform chemicals. The process comprises dissolving the polysaccharides in a inorganic molten salt hydrate, converting the polysaccharides to monosaccharides, and converting the monosaccharides to platform chemicals that are easily separable from the inorganic molten salt hydrate. Preferably the polysaccharides are provided in the form of a biomass, more preferably a ligno-cellulosic biomass.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: May 21, 2013
    Assignee: BIOeCON International Holding N.V.
    Inventors: Paul O'Connor, Rafael Menegassi De Almeida, Jacob A. Moulijn, Michiel Makkee, Sjoerd Daamen
  • Patent number: 8404870
    Abstract: The present invention relates to ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylates and a process for the production thereof. Furthermore, the present invention relates to a process for the production of statins and in particular of Rosuvastatin and derivates thereof, wherein the above mentioned compounds are used as intermediates.
    Type: Grant
    Filed: January 20, 2009
    Date of Patent: March 26, 2013
    Assignee: LEK Pharmaceuticals D.D.
    Inventors: Jerome Cluzeau, Zdenko Casar, Peter Mrak, Matej Oslaj, Gregor Kopitar
  • Patent number: 8399509
    Abstract: Novel compounds of the formula (I), in which X has the meaning indicated in Patent Claim 1, are suitable as antidiabetics.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: March 19, 2013
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Christos Tsaklakidis, Norbert Beier
  • Patent number: 8383786
    Abstract: The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is disclosed.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: February 26, 2013
    Assignee: Dow AgroSciences, LLC.
    Inventors: Gary D. Crouse, Thomas C. Sparks, CaSandra Lee McLeod, David A. Demeter, Zoltan L. Benko, Debra L. Camper
  • Patent number: 8372306
    Abstract: A liquid crystal compound is provided that has excellent characteristics, such as a negatively large dielectric anisotropy. A liquid crystal composition containing the compound, and a liquid crystal display device containing the composition are also provided. A compound having the three factors, i.e., (1) a tetrahydropyran ring, (2) terminal alkenyl chain and (3) exhibits excellent characteristics including a negatively large dielectric anisotropy (??). The use of the compound having the characteristics provides an excellent liquid crystal composition and an excellent liquid crystal display device.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: February 12, 2013
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Tokifumi Masukawa
  • Patent number: 8343943
    Abstract: Disclosed herein is a cancer sensitizer comprising glucosamine, a glucosamine derivative, or a salt thereof. When administered to patients with cancer, the cancer sensitizer functions to sensitize cancer cells to anticancer agents without producing side effects, thereby increasing the therapeutic efficiency of chemotherapy.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: January 1, 2013
    Assignee: National Cancer Center
    Inventors: Soo Youl Kim, Dae Seok Kim
  • Publication number: 20120323014
    Abstract: A method for producing an ?-acyloxycarbonyl compound of the present invention includes performing an intermolecular reaction between a carboxylic acid and a carbonyl compound selected from the group consisting of ketones, aldehydes, and esters, which have a hydrogen atom at the ?-position, using a hydroperoxide as an oxidizer and an iodide salt as a catalyst precursor, thereby introducing an acyloxy group derived from the carboxylic acid into the ?-position of the carbonyl compound.
    Type: Application
    Filed: March 4, 2011
    Publication date: December 20, 2012
    Applicants: MITSUBISHI RAYON CO., LTD., National University Corporation Nagoya University
    Inventors: Kazuaki Ishihara, Muhammet Uyanik
  • Publication number: 20120323011
    Abstract: There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Ra represents an alkyl group, such as a C1-16 alkyl group, and preferably an isopropyl group; Rb represents an aryl group, preferably a 4-fluorophenyl group; Rc represents hydrogen, a protecting group or an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO2Re group where Re is an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group.
    Type: Application
    Filed: August 30, 2012
    Publication date: December 20, 2012
    Inventors: David John Moody, Jonathan William Wiffen
  • Patent number: 8278349
    Abstract: Methods of treating cancer by administering effective amounts of a Ras antagonist comprising FTS, or analogs thereof, or a pharmaceutically acceptable salt, and 2-deoxyglucose (2DG) to a patient are disclosed. Pharmaceutical compositions useful in treating cancer containing a Ras antagonist comprising FTS, or analogs thereof, or a pharmaceutically acceptable salt, and 2DG are also disclosed.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: October 2, 2012
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Yoel Kloog, Liat Goldberg, Michael Brownstein
  • Patent number: 8252782
    Abstract: The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of formula (I).
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 28, 2012
    Assignee: Pfizer Inc.
    Inventors: Steven Joseph Brickner, Mark Edward Flanagan, Manjinder Singh Lall
  • Patent number: 8247581
    Abstract: Process for converting cellulose and hemicellulose in hydroxymethylpyranone and isomers, using as a solvent and catalyst a mixture of N alkyl imidazolium chloride and hydrochloric acid 37%, where hydroxymethylpyranone is extracted with butanol and hydrogenated to methylpyran and isomers.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: August 21, 2012
    Inventor: Pedro Manuel Brito da Silva Correia
  • Publication number: 20120196333
    Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.
    Type: Application
    Filed: March 12, 2012
    Publication date: August 2, 2012
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: ZDENKO CASAR, TOMAZ MESAR, GREGOR KOPITAR, PETER MRAK, MATEJ OSLAJ
  • Publication number: 20120148595
    Abstract: The present invention relates to GABA-linked anthracycline-lipid conjugates and to methods of using the conjugates to treat cancer. Methods for making the GABA-linked anthracycline lipid conjugates are also provided.
    Type: Application
    Filed: March 11, 2010
    Publication date: June 14, 2012
    Applicant: Luitpold Pharmaceuticals, Inc.
    Inventors: Charles S. Swindell, Glenn G. Fegley, Hema M. Sundar, Richard Lawrence