Hydroxy Or Halogen Attached Directly Or Indirectly To The Hetero Ring By Acyclic Nonionic Bonding (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 549/423)
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Patent number: 9695142Abstract: The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans.Type: GrantFiled: April 28, 2014Date of Patent: July 4, 2017Assignee: BASF SEInventors: Timon Stork, Karl Beck, Gabriele Gralla, Oliver Bey, Klaus Ebel
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Patent number: 9428481Abstract: The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans by reacting 3-methylbut-3-en-1-ol (isoprenol) with the corresponding alkenealdehydes in the presence of a strongly acidic ion exchanger with subsequent hydrogenation. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with prenal, with subsequent hydrogenation.Type: GrantFiled: April 2, 2014Date of Patent: August 30, 2016Assignee: BASF SEInventors: Gabriele Gralla, Ralf Pelzer
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Patent number: 9139549Abstract: The present invention relates to a process for the integrated preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans and of 2-substituted 4-methyltetrahydropyrans.Type: GrantFiled: October 14, 2013Date of Patent: September 22, 2015Assignee: BASF SEInventors: Timon Stork, Oskar Röder, Klaus Ebel, Ralf Pelzer, Wolfgang Krause, Karl Beck
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Publication number: 20150148347Abstract: A compound of formula I, wherein the groups R1, R2, R3, X, m, and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.Type: ApplicationFiled: November 25, 2014Publication date: May 28, 2015Inventors: Iain LINGARD, Dieter HAMPRECHT
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Patent number: 9006403Abstract: Provided are processes for the preparation of complexes that are useful in purifying compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The processes can reduce the number of steps needed to obtain the target compounds and the complexes formed in the processes are typically provided in a crystalline form.Type: GrantFiled: August 31, 2012Date of Patent: April 14, 2015Assignee: Theracos, Inc.Inventors: Jason Liou, Yuelin Wu, Shengbin Li, Ge Xu
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Patent number: 8956999Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds of formula (I), which are suitable for use as herbicides.Type: GrantFiled: June 26, 2008Date of Patent: February 17, 2015Assignees: Syngenta Limited, Syngenta Crop Protection LLCInventors: Stephane André Marie Jeanmart, Christopher John Mathews, John Benjamin Taylor, Mangala Govenkar, Stephen Christopher Smith
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Patent number: 8933251Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.Type: GrantFiled: March 20, 2013Date of Patent: January 13, 2015Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeru Watanabe, Satoshi Shinachi, Takeshi Kinsho, Koji Hasegawa, Yuji Harada, Jun Hatakeyama, Kazunori Maeda, Tomohiro Kobayashi
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Publication number: 20140213803Abstract: The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans by reacting 3-methylbut-3-en-1-ol (isoprenol) with the corresponding alkenealdehydes in the presence of a strongly acidic ion exchanger with subsequent hydrogenation. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with prenal, with subsequent hydrogenation.Type: ApplicationFiled: April 2, 2014Publication date: July 31, 2014Applicant: BASF SEInventors: Gabriele Gralla, Ralf Pelzer
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Patent number: 8791276Abstract: Process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans of the formula (I) where the radical R1 is a straight-chain or branched alkyl or alkenyl radical having 1 to 12 carbon atoms, an optionally alkyl-substituted cycloalkyl radical having in total 3 to 12 carbon atoms or an optionally alkyl- and/or alkoxy-substituted aryl radical having in total 6 to 12 carbon atoms, comprising the reaction of 3-methylbut-3-en-1-ol of the formula (II) with an aldehyde of the formula (III) R1—CHO??(III), where the radical R1 has the same meaning as in formula (I) and where the reaction is carried out in the presence of water and in the presence of a strongly acidic cation exchanger, and then the isolation and/or the distillative separation is carried out in a dividing wall column or in an interconnection of (at least) two distillation columns in the form of a thermal coupling and one or more side take-off points at an absolute operating pressure of up to 500 mbar.Type: GrantFiled: June 10, 2011Date of Patent: July 29, 2014Assignee: BASF SEInventors: Gabriele Gralla, Karl Beck, Margarethe Klos, Ulrich Griesbach
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Patent number: 8779169Abstract: The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans by reacting 3-methylbut-3-en-1-ol(isoprenol) with the corresponding alkenealdehydes in the presence of a strongly acidic ion exchanger with subsequent hydrogenation. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with prenal, with subsequent hydrogenation.Type: GrantFiled: May 26, 2011Date of Patent: July 15, 2014Assignee: BASF SEInventors: Gabriele Gralla, Ralf Pelzer
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Publication number: 20140155637Abstract: The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.Type: ApplicationFiled: May 24, 2012Publication date: June 5, 2014Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Peter Fey, Agathe Christine Mayer
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Patent number: 8618315Abstract: The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyranols by reacting 3-methylbut-3-en-1-ol (isoprenol) with the corresponding aldehydes in the presence of a strongly acidic cation exchanger. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with isovaleraldehyde.Type: GrantFiled: May 11, 2010Date of Patent: December 31, 2013Assignee: BASF SEInventors: Gabriele Gralla, Ralf Pelzer, Klaus Ebel, Ulrich Griesbach, Jörg Botzem
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Publication number: 20130245130Abstract: Provided herein are pure and isolated natural products and analogs thereof of Formula (I), (II), (III), and (IV), pharmaceutical compositions thereof, and methods of use, for example, for treating a bacterial infection. Further provided are methods useful in identifying an inhibitor of bacterial sugar fermentation in a bacterial strain, such as a compound (inhibitor) of Formula (I), (II), (III), or (IV): or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 25, 2013Publication date: September 19, 2013Applicants: President and Fellows of Harvard College, Children's Medical Center CorporationInventors: Paula I. Watnick, Patrick Ymele-Leki, Jon Clardy, Shugeng Cao
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Publication number: 20130172578Abstract: Disclosed are processes for preparing 1,6-hexanediol and synthetic intermediates useful in the production of 1,6-hexanediol from renewable biosources. In one embodiment, a process comprises contacting levoglucosenone with hydrogen in the presence of a first hydrogenation catalyst at a first temperature to form product mixture (I); and heating product mixture (I) in the presence of hydrogen and a second hydrogenation catalyst at a second temperature to form product mixture (II) which comprises 1,6-hexanediol.Type: ApplicationFiled: December 28, 2012Publication date: July 4, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventor: E I DU PONT DE NEMOURS AND COMPANY
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Patent number: 8471045Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.Type: GrantFiled: March 12, 2012Date of Patent: June 25, 2013Assignee: Lek Pharmaceuticals D.D.Inventors: Zdenko Casar, Tomaz Mesar, Gregor Kopitar, Peter Mrak, Matej Oslaj
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Publication number: 20130018077Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.Type: ApplicationFiled: September 14, 2012Publication date: January 17, 2013Applicant: Acucela Inc.Inventors: Ian Leslie Scott, Vladmir Aleksandrovich Kuksa, Mark W. Orme, Thomas Little, Anna Gall, Jennifer Gage, Feng Hong
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Patent number: 8242289Abstract: The present invention relates to alkyl-substituted tetrahydropyrans, mixtures containing these alkyl-substituted tetrahydropyrans, their respective use and corresponding flavored products.Type: GrantFiled: January 29, 2010Date of Patent: August 14, 2012Assignee: SYMRISE AGInventors: Heiko Oertling, Constanze Brocke, Hubert Loges, Arnold Machinek
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Publication number: 20110319641Abstract: The present invention is directed to a novel method for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction. Also described are methods of preparing treprostinil comprising the alkyne addition reaction described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.Type: ApplicationFiled: June 2, 2011Publication date: December 29, 2011Inventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
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Publication number: 20110269709Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.Type: ApplicationFiled: December 23, 2010Publication date: November 3, 2011Inventor: Apparao Satyam
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Publication number: 20110190127Abstract: Pyranone, thiopyranone and cyclohexenedione compounds of formula (I), which are suitable for use as herbicides.Type: ApplicationFiled: June 4, 2009Publication date: August 4, 2011Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: James Nicholas Scutt, Christopher John Mathews
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Patent number: 7989665Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with tetradentate ligands having at least one amino or imino coordinating group and at least one phosphino coordinating group in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.Type: GrantFiled: September 13, 2007Date of Patent: August 2, 2011Assignee: Firmenich SAInventors: Lionel Saudan, Philippe Dupau, Jean-Jacques Riedhauser, Patrick Wyss
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Patent number: 7951839Abstract: The present invention related to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppression of aging and stress. It becomes possible to develop medical substances using the pheromone relating to aging, stress, metabolism, signal transfer system in vivo, and anticancer, obesity and a suppressing agent for aging and stress.Type: GrantFiled: October 30, 2007Date of Patent: May 31, 2011Assignee: KDR Biotech. Co. Ltd.Inventors: Mankil Jung, Young Ki Paik
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Publication number: 20110124844Abstract: Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commerial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality.Type: ApplicationFiled: January 27, 2011Publication date: May 26, 2011Inventors: Paul D. Davis, Edward C. Crapps
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Publication number: 20110097296Abstract: A process of preparing a compound of formula (I) wherein R represents a linear or branched C5 alkyl group, as well as the use of such compounds in a fragrant and/or flavouring composition.Type: ApplicationFiled: April 21, 2009Publication date: April 28, 2011Inventors: Jean Mane, Caroline Plessis, Jean-Jacques Chanot
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Patent number: 7875737Abstract: Pyran derivatives of general formula (I) wherein Y is a 5-, 6- or 7-membered ring, preferably a 5-membered ring, methyl or ethyl mono- or polysubstituted, and optionally unsaturated, and R1, R2, R3, R4 are, each independently, a hydrogen atom or a linear or branched C1-5 alkyl or C2-5 alkenyl group, and X is present or absent; when X is present, R5, R6, R7, R8, R9 are all present, and X is a hydrogen atom or an OZ group, wherein Z is a hydrogen atom or a R10 group or a C(O)R10 group; when X is absent, a double bond involving the carbon atom at the 4 position is present and R7, R8 and R9 are present, and one of R5 or R6 is present and the other one is absent, or R5, R6, and R7 are present, and one of R8 or R9 is present and the other one is absent, or R7 is a ?C(R11)(R12) group and R5, R6, R8, R9 are present; and when they are present, each of R5-R12 group is, independently, a hydrogen atom or a linear or branched C1-5 alkyl or C2-5 alkenyl group; and use of at least one pyran derivative of formula (I)Type: GrantFiled: November 30, 2007Date of Patent: January 25, 2011Assignee: V. Mane FilsInventors: Caroline Plessis, Jean Mane
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Patent number: 7772191Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.Type: GrantFiled: May 3, 2006Date of Patent: August 10, 2010Assignee: Boehringer Ingelheim International GmbHInventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhengxu Han
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Publication number: 20100125144Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with tetradentate ligands having at least one amino or imino coordinating group and at least one phosphino coordinating group in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.Type: ApplicationFiled: January 27, 2010Publication date: May 20, 2010Inventors: LIONEL SAUDAN, PHILIPPE DUPAU, JEAN-JACQUES RIEDHAUSER, PATRICK WYSS
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Patent number: 7638256Abstract: Silicon compounds having fluorinated hemiacetal structure are provided. Silicone resins having the same structure have an appropriate acidity to enable formation of a finer pattern by minimizing the pattern collapse by swelling, exhibit improved resistance to the etching used in the pattern transfer to an organic film, and are thus suited for use in resist compositions for the bilayer process.Type: GrantFiled: July 6, 2006Date of Patent: December 29, 2009Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeshi Kinsho, Takeru Watanabe, Mutsuo Nakashima, Yoshitaka Hamada
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Patent number: 7521568Abstract: Enantiopure substituted 4-deoxypentenosides (4-DPs) and related dihydropyrans (DHPs) are prepared from common carbohydrates via a novel process. The 4-DPs and related DHPs are amenable to a broad range of stereoselective transformations and are used as synthetic intermediates to prepare a variety of enantiopure tetrahydropyrans (THPs), including rare or exotic sugars and other complex THPs of commercial or medicinal value. In one embodiment of the instant invention, 4-DPs are converted to L-sugars in a novel process that offers distinct advantages over known synthetic methods.Type: GrantFiled: December 13, 2002Date of Patent: April 21, 2009Assignee: Purdue Research FoundationInventors: Alexander Wei, Fabien P. Boulineau
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Publication number: 20080312186Abstract: The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, Ralk, —ORO, and -Q are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and/or activity, and inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.Type: ApplicationFiled: August 19, 2008Publication date: December 18, 2008Applicant: The University Court of the University of AberdeenInventors: Stuart H. RALSTON, Iain R. GREIG, Aymen I. I. MOHAMED, Robert J. VAN 'T HOF
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Patent number: 7354936Abstract: The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula processes for their preparation, pharmaceutical compositions containing them, and their medical uses.Type: GrantFiled: September 16, 2002Date of Patent: April 8, 2008Assignee: Almirall AGInventors: Maria Isabel Crespo Crespo, Juan Miguel Jimenez Mayorga, Josep Lluis Matallana Julia, Joan Feixas Gras
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Patent number: 7326798Abstract: The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds.Type: GrantFiled: April 21, 2005Date of Patent: February 5, 2008Assignee: Schering AGInventors: Johannes Platzek, Orlin Petrov, Marc Willuhn, Klaus Dieter Graske, Werner Skuballa
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Patent number: 7304169Abstract: The present invention relates to a process for preparing tetrahydropyran-4-ol which comprises the steps of (A) a cyclization step of preparing tetrahydropyranyl-4-formate represented by the formula (1): by reacting 3-buten-1-ol, a formaldehyde compound and formic acid, and (B) then, a solvolysis step of subjecting the tetrahydropyranyl-4-formate to solvolysis to obtain tetrahydropyran-4-ol represented by the formula (2): and an intermediate and a process for preparing the same.Type: GrantFiled: June 10, 2003Date of Patent: December 4, 2007Assignee: Ube Industries, Ltd.Inventors: Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Shinobu Suzuki
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Patent number: 6919160Abstract: Disclosed herein is an acrylic compound that can be polymerized by itself or with at least one other ethylenically unsaturated monomer to provide a polymer. The polymer may be used, for example, within a sub-200 nm photoresist composition. Also disclosed is a method to make the acrylic compound of the present invention from the raw material trifluoroacetone.Type: GrantFiled: February 20, 2003Date of Patent: July 19, 2005Assignee: Air Products and Chemicals, Inc.Inventors: Atteye Houssein Abdourazak, Thomas John Markley
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Patent number: 6828447Abstract: This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.Type: GrantFiled: April 2, 2002Date of Patent: December 7, 2004Assignee: AtheroGenics, Inc.Inventor: Charles Q. Meng
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Patent number: 6716999Abstract: A method for producing pyrone derivatives of the general formula (I), wherein X1 is halomethyl, whereby an acetoacetic acid derivative of the general formula (II), wherein X1 has the aforementioned meaning and X2 is chlorine or bromine, is treated with a Lewis acid and is subsequently converted into the desired product by means of water.Type: GrantFiled: August 12, 2002Date of Patent: April 6, 2004Assignee: Lonza AGInventors: Walter Brieden, Michael Gottsponer
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Patent number: 6646170Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: GrantFiled: April 26, 2002Date of Patent: November 11, 2003Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 6479538Abstract: Novel cyclic ether vitamin D3 compounds having a cyclic ether side chain are disclosed. These compounds were first identified as metabolites of 3-epi vitamin D3 produced via a tissue-specific metabolic pathway which catalyzes the formation of a cyclic ether structure. Also disclosed are 1&agr;(OH) 3-epi vitamin D3 compounds, which are produced via the epimerization of a 3-&bgr;-hydroxyl group of 1&agr;(OH) vitamin D3 precursor in vivo. The vitamin D3 compounds of the present invention can be used as substitutes for natural and synthetic vitamin D3 compounds.Type: GrantFiled: July 17, 2000Date of Patent: November 12, 2002Assignee: Women and Infants HospitalInventor: Satayanarayana G. Reddy
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Patent number: 6451766Abstract: Compounds of formula (I) or their salts or esters: [wherein R1 is alkyl or haloalkyl; R2 and R3 each represents hydrogen or aliphatic acyl; X is hydroxy, halogen, alkoxy, or a group of formula RaO—, where Ra is aliphatic acyl; Y is a group of formula RbRcN— or RbRcN—O—, where Rb and Rc each is hydrogen or alkyl; and Z is oxygen or sulfur] have excellent sialidase inhibitory activity and are therefore useful for the treatment and prevention of influenza and other viral diseases where the replication of the virus is susceptible to sialidase inhibitors.Type: GrantFiled: October 3, 2001Date of Patent: September 17, 2002Assignee: Sankyo Company, LimitedInventors: Takeshi Honda, Yoshiyuki Kobayashi, Makoto Yamashita
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Patent number: 6426421Abstract: One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.Type: GrantFiled: November 21, 2000Date of Patent: July 30, 2002Assignee: Massachusetts Institute of TechnologyInventors: Stephen L. Buchwald, Obadiah J. Plante, Peter H. Seeberger
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Patent number: 6392061Abstract: This invention relates to novel processes for making (2S, 3S, 5S) oxetanone derivative lipase inhibitor compounds and intermediates therefor, which processes for producing such derivatives that are useful as lipase inhibitors are capable of being scaled to commercial quantities. Further the invention relates to processes for producing salts and for producing pharmaceutical compositions compounds comprising at least one such oxetanone derivative or salt, as well as methods for using such compounds and compositions for inhibiting lipases.Type: GrantFiled: April 23, 2001Date of Patent: May 21, 2002Assignee: Zpro Chemical, Inc.Inventor: John Jason Gentry Mullins
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Patent number: 6300106Abstract: A method of producing (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methane sulfonate using 1,3-butadiene and a ketoethanal to form an intermediate racemic mixture. The racemic mixture is resolved to remove one isomer from the reaction product mixture. Following resolution, the following steps are performed: reduce the isomer to an alcohol, react the alcohol with triphenylmethyl chloride, ozonalyze the resulting reaction product, reduce the ozonalyzed product to yield a diol and react the diol with a methane sulfonyl compound to form (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methane sulfonate. Alternatively, the racemic mixture may first be reduced and the resulting racemic alcohol mixture is resolved to isolate one isomer of the alcohol and the remaining process steps are followed.Type: GrantFiled: November 22, 2000Date of Patent: October 9, 2001Assignee: PPG Industries Ohio, Inc.Inventor: Jean-Claude Caille
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Patent number: 6211387Abstract: A compound of formula (II), wherein R1 is chloro, fluoro or trifluoromethyl; R2 is hydrogen, chloro, fluoro or trifluoromethyl; and R is hydrogen or a protective group for the hydroxy moiety useful as an intermediate for the synthesis of antimycotic azole compounnds.Type: GrantFiled: June 5, 2000Date of Patent: April 3, 2001Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Marco Villa, Aldo Belli, Giancarlo Grancini, Biase Continanza
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Patent number: 6136986Abstract: The invention relates to a process for preparing substituted chroman derivatives of the general formula VII, ##STR1## where X is the group --CN, --COOR.sup.3, --CHO, --CH.sub.2 OR.sup.7 or --CH(OR.sup.8).sub.2,R.sup.2 is a C.sub.1 -C.sub.23 -alkyl, C.sub.2 -C.sub.23 -alkenyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl radical,R.sup.3 is hydrogen or an optionally substituted C.sub.1 -C.sub.4 -alkyl radical,R.sup.4, R.sup.5, R.sup.6 are, independently of one another, hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,R.sup.7 is hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical, or the two radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or may carry one or two carboxyl groups, cyclohexyl or phenyl radicals,and to the novel intermediates of the process.Type: GrantFiled: December 13, 1999Date of Patent: October 24, 2000Assignee: BASF AktiengesellschaftInventors: Rainer Sturmer, Kai-Uwe Baldenius
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Patent number: 6072089Type: GrantFiled: July 30, 1997Date of Patent: June 6, 2000Assignee: Kyowa Yuka Co., Ltd.Inventors: Satoru Mizutani, Toshiaki Ogata, Nobuhito Amemiya, Kenji Mutoh
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Patent number: 5981496Abstract: Novel .alpha.-pyrones are described. The .alpha.-pyrones are useful in a method for controlling .alpha.-pyrone responsive states in a mammal. The method includes administering to a mammal a therapeutically effective amount of an .alpha.-pyrone such that control of .alpha.-pyrone responsive states in a mammal occurs. .alpha.-Pyrone responsive states can be associated with undesirable cell proliferation such as bacteria or cancer. Packaged pharmaceuticals and pharmaceutical compositions including the novel .alpha.-pyrones are also described.Type: GrantFiled: September 19, 1997Date of Patent: November 9, 1999Assignee: Millennium Pharmaceutical, Inc.Inventors: Seth Cohen, Zhi-Dong Jiang
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Patent number: 5952376Abstract: Triene-containing compounds which mimic the chemical and/or biological activity of the spongistatins are provided, as are methods and intermediates useful in their preparation.Type: GrantFiled: November 7, 1997Date of Patent: September 14, 1999Assignee: The Trustees of the University of PennsylvaniaInventors: Amos B. Smith, III, Qiyan Lin
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Patent number: 5888969Abstract: The present invention relates to the use of cytokine restraining agents to treat inflammatory bowel disease.Type: GrantFiled: July 14, 1997Date of Patent: March 30, 1999Assignee: Trega Biosciences, Inc.Inventors: Beverly E. Girten, Ronald R. Tuttle
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Patent number: 5869523Abstract: Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolinProcess for the manufacture of 6.beta.Type: GrantFiled: July 22, 1991Date of Patent: February 9, 1999Assignee: Hoechst AktiengesellschaftInventors: Noel John de Souza, Adolf D'Sa, Samba Laxminarayan Kattige, Gulab Bajirao Padwal, Jurgen Blumbach
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Patent number: 5852051Abstract: Compounds of the formula I ##STR1## in which R.sup.1, A and B have the meanings stated in the description, and the preparation thereof are described. The novel compounds are suitable for controlling diseases.Type: GrantFiled: June 5, 1997Date of Patent: December 22, 1998Assignee: BASF AktiengesellschaftInventors: Hans-Joachim Bohm, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Hans Wolfgang Hoffken, Wilfried Hornberger, Thomas Zierke