Chalcogen Attached Directly To The Tricyclo Ring System By Nonionic Bonding Patents (Class 549/44)
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Patent number: 10934309Abstract: This invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof [Therein, A is O, S, or N—R6; ring G is a 5-membered or 6-membered aromatic ring, etc., including 1-3 heteroatoms selected from O, S and N as constituent atoms; R1 and R2 are each independently a hydrogen atom, a halogen atom, or an optionally-substituted C1-6 alkyl carbonyl group, etc.; R3, R4 and R5 are each independently a hydrogen atom, a halogen atom, or an optionally-substituted C1-6 alkyl carbonyl group, etc.; and R6 is a hydrogen atom or an optionally-substituted C1-6 alkyl group, etc.].Type: GrantFiled: December 27, 2018Date of Patent: March 2, 2021Assignee: Sumitomo Dainippon Pharma Oncology, Inc.Inventors: Hitoshi Ban, Seiji Kamioka, Shoukou Ri, Tomoyuki Furuta, Hiroyuki Kitano, Chiang Jia Li
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Patent number: 10221153Abstract: The present invention generally relates to various dibenzothiophene compounds, processes for preparing these compounds, and use of these compounds in organic light-emitting diodes and as cellular imaging agents. In particular, the compounds of the present invention include various sulfoxide and sulfone analogs of various dibenzothiophene compounds. The present invention also relates to cell imaging agents comprising one or more of the dibenzothiophene compounds and processes for imaging a cell using the compounds. The present invention also relates to organic light-emitting diodes comprising one or more of the dibenzothiophene compounds and processes for preparing these organic light-emitting diodes.Type: GrantFiled: May 3, 2018Date of Patent: March 5, 2019Assignee: Saint Louis UniversityInventors: John T. Petroff, II, Ryan D. McCulla, Christopher Arnatt
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Patent number: 9040726Abstract: An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.Type: GrantFiled: September 3, 2009Date of Patent: May 26, 2015Assignee: Mallinckrodt LLCInventors: Peter X. Wang, Gary L. Cantrell, Robert E. Halvachs, Kevin R. Roesch, Henry J. Buehler, Joseph P. Haar
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Publication number: 20150018410Abstract: The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.Type: ApplicationFiled: September 29, 2014Publication date: January 15, 2015Inventors: Zhiwei Jiang, Chiang Jia Li, Wei Li, David Leggett
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Publication number: 20140256784Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.Type: ApplicationFiled: May 21, 2014Publication date: September 11, 2014Inventors: Joseph BARBOSA, Kenneth Gordon CARSON, Michael Walter GARDYAN, Jason Patrick HEALY, Qiang HAN, Ross MABON, Praveen PABBA, James TARVER, JR., Kristen M. TERRANOVA, Ashok TUNOORI, Xiaolian XU
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Publication number: 20140231775Abstract: A dendrimer compound characterized by comprising a core represented by the following formula (1-1), (1-2), (1-3), or (1-4) and at least one kind of dendritic structure selected among dendritic structures represented by the following formulae (3) and (4).Type: ApplicationFiled: April 9, 2014Publication date: August 21, 2014Inventors: Makoto KITANO, Yoshiaki TSUBATA
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Publication number: 20140221664Abstract: The inventions disclosed and described herein relate to new and efficient generic methods for making a wide variety of compounds having HAr—Z-Har tricyclic cores, wherein HAr is an optionally substituted five or six membered heteroaryl ring, and Hal is a halogen, and Z is a bridging radical, such as S, Sc, NR5, C(O), C(O)C(O), Si(R5)2, SO, SO2, PR5, BR5, C(R5)2 or P(O)R5 and both HAr are covalently bound to one another. The synthetic methods employ a “Base-Catalyzed Halogen Dance” reaction to prepare a metallated compound comprising a five or six membered heteroaryl ring comprising a halogen atom, and then oxidatively coupling the reactive intermediate compound. The compounds of Formula (II) and/or oligomer or polymers comprising repeat units having Formula (II) can be useful for making semi-conducting materials, and/or electronic devices comprising those materials. Acyl compounds can be prepared. Heteroarylene substituents can be used. The core tricyclic core can be coupled to itself.Type: ApplicationFiled: August 9, 2012Publication date: August 7, 2014Applicant: GEORGIA TECH RESEARCH CORPORATIONInventors: Yulia A. Getmanenko, Seth Marder, Do Kyung Hwang, Bernard Kippelen
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Publication number: 20140209839Abstract: The invention relates to novel polymers containing one or more 4,8-dioxycarbonylalkyl-benzo[1,2-b:4,5-b?]dithiophene repeating units or their thioester derivatives, methods for their preparation and monomers used therein, blends, mixtures and formulations containing them, the use of the polymers, blends, mixtures and formulations as semiconductor in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, and to OE and OPV devices comprising these polymers, blends, mixtures or formulations.Type: ApplicationFiled: August 29, 2012Publication date: July 31, 2014Applicant: MERCK PATENT GMBHInventors: William Mitchell, Nicolas Blouin, Amy Phillips, Steven Tierney, Miguel Carrasco-Orozco, Toby Cull
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Publication number: 20140142308Abstract: Receptor type oligothiopene compounds, methods of preparing the compounds, and use of the compounds in photoelectric materials.Type: ApplicationFiled: March 27, 2012Publication date: May 22, 2014Applicant: NANKAI UNIVERSITYInventors: Yongsheng Chen, Xiangjian Wan, Yongsheng Liu, Zhi Li, Jiaoyan Zhou, Fei Wang, Guangrui He, Guankui Long
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Publication number: 20130302422Abstract: Provided is a pharmaceutical composition for the treatment and prevention of kidney diseases, containing (a) a therapeutically effective amount of a compound represented by Formulae 1 or 2 or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and (b) a pharmaceutically acceptable carrier, diluent or excipient or any combination thereof.Type: ApplicationFiled: May 22, 2013Publication date: November 14, 2013Applicants: KT & G CORPORATION, MAZENCE INC.Inventors: Taehwan Kwak, Myung-Gyu Park, Kyoung Hoon Jung
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Publication number: 20130102785Abstract: The inventions disclosed and described herein relate to new and efficient generic methods for making a wide variety of compounds having Formulas (I) and (II) as shown below (Formulas (I) and (II)) wherein HAr is an optionally substituted five or six membered heteroaryl ring, and Hal is a halogen, and Y is a bridging radical, such as S, Se, NR5C(O), C(O)C(O), Si(R5)2, SO, SO2, PR5, BR5, C(R5)2 or P(O)R5. The synthetic methods employ a “Base-Catalyzed Halogen Dance” reaction to prepare a metallated compound comprising a five or six membered heteroaryl ring comprising a halogen atom, and then oxidatively coupling the reactive intermediate compound. The compounds of Formula (II) and/or oligomer or polymers comprising repeat units having Formula (II) can be useful for making semi-conducting materials, and/or electronic devices comprising those materials.Type: ApplicationFiled: February 9, 2011Publication date: April 25, 2013Applicant: Georgia Tech Research CorporationInventors: Seth Marder, Yulia Alexandrovna Getmanenko
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Publication number: 20120302562Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.Type: ApplicationFiled: May 23, 2012Publication date: November 29, 2012Inventors: Joseph BARBOSA, Kenneth Gordon CARSON, Michael Walter GARDYAN, Jason Patrick HEALY, Qiang HAN, Ross MABON, Praveen PABBA, James TARVER, JR., Kristen M. TERRANOVA, Ashok TUNOORI, Xiaolian XU
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Publication number: 20120289577Abstract: The present invention relates to a composition for treating or preventing hearing loss comprising naphthoquinone-based compounds.Type: ApplicationFiled: December 27, 2010Publication date: November 15, 2012Applicant: KT&G LIFE SCIENCES CORPORATIONInventors: Tae Hwan Kwak, Myung-Gyu Park, Hong-Seob So, Raekil Park, Hyung-Jin Kim
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Publication number: 20120271052Abstract: LED compounds of the general structure: (B-S-)n-A-(- S-B)m (Structure 1); wherein the rod-like molecular nucleus A having the structure: —Ar(-T-Ar)p- (Structure 2); wherein T includes a diradical.Type: ApplicationFiled: September 29, 2010Publication date: October 25, 2012Applicant: LOMOX LIMITEDInventor: Gene Karl Koch
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Publication number: 20120238765Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.Type: ApplicationFiled: June 4, 2012Publication date: September 20, 2012Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Satoshi KOBAYASHI, Satoshi Mikami
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Publication number: 20120205596Abstract: The present invention provides a macromolecular compound by which the short-circuit current density and the photoelectric conversion efficiency are enhanced when the macromolecular compound is used in an organic layer contained in a photovoltaic cell.Type: ApplicationFiled: October 29, 2010Publication date: August 16, 2012Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Ken Yoshimura, Kenichiro Ohya
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Patent number: 8222426Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2-Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.Type: GrantFiled: June 15, 2010Date of Patent: July 17, 2012Assignee: Sumitomo Chemical Company, LimitedInventors: Satoshi Kobayashi, Satoshi Mikami
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Patent number: 8158275Abstract: Fluorinated compounds of the invention are represented by the following general formula (I): (in formula (I), Ar1 and Ar2 each independently represent a C10 or greater aromatic hydrocarbon or C4 or greater heterocyclic group, R1 represents hydrogen or a monovalent substituent, R2 and R3 each independently represent a monovalent substituent, and s1 and t1 each independently represent an integer of 0 or greater. When s1 is 2 or greater, the multiple R2 groups may be the same or different, and when t1 is 2 or greater the multiple R3 groups may be the same or different.Type: GrantFiled: February 22, 2007Date of Patent: April 17, 2012Assignees: Osaka University, Sumitomo Chemical Company, LimitedInventors: Yutaka Ie, Yoshio Aso, Masashi Nitani, Masato Ueda
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Publication number: 20120077986Abstract: The present invention is directed to provide a novel preparation of anticancer-active tricyclic compounds via alkyne coupling reaction. The present invention provides a process for preparing a compound of formula (Ia) or (Ib): wherein R1 is optionally substituted C1-6 alkyl, etc.; W is O, S or NR2; R2 is hydrogen atom, etc., which comprises Step (a) in which a compound of formula (II): wherein R1 is the same as defined above, and a compound of formula (III) or (IV): wherein R2 is the same as defined above; R3 is hydrogen atom, etc.; X is halogen atom, etc., are reacted in the presence of a base, a copper catalyst and a palladium catalyst in an aprotic polar solvent.Type: ApplicationFiled: July 26, 2011Publication date: March 29, 2012Applicant: TAHEEBO JAPAN CO., LTD.Inventors: Akira IIDA, Kazunori UEDA, Mitsuaki YAMASHITA
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Publication number: 20120035170Abstract: This invention concerns novel substituted unsaturated tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonine receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in claim 1.Type: ApplicationFiled: August 22, 2011Publication date: February 9, 2012Inventors: José Maria Núñez, Antonius Adrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez
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Patent number: 8110333Abstract: A resist composition includes (A) a compound represented by the following formula (I): wherein each of R1 to R13 independently represents a hydrogen atom or a substituent, provided that at least one of R1 to R13 is a substituent containing an alcoholic hydroxyl group; Z represents a single bond or a divalent linking group; and X? represents an anion containing a proton acceptor functional group.Type: GrantFiled: August 1, 2008Date of Patent: February 7, 2012Assignee: Fujifilm CorporationInventors: Sou Kamimura, Yasutomo Kawanishi, Kenji Wada, Tomotaka Tsuchimura
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Publication number: 20110313032Abstract: The present invention is directed to a compound of formula (I), its diastereoisomers, its enantiomers or its pharmaceutically acceptable salts or solvates, formula (I), to procedures of obtaining the same, to intermediates thereof, and use as competitive inhibitors of the third enzyme of the shikimic acid pathway, the type II dehydroquinase.Type: ApplicationFiled: December 23, 2009Publication date: December 22, 2011Applicant: UNIVERSIDADE DE SANTIAGO DE COMPOSTELAInventors: Cóncepcion González Bello, Verónica Filipa Vieira Prazeres, Sonia Paz Gómez, Cristina Sánchez Sixto, Lorena Tizón Valverde
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Patent number: 7964650Abstract: Carbonyl-functionalized oligo/polythiophene compounds, and related semiconductor components and related device structures.Type: GrantFiled: April 29, 2009Date of Patent: June 21, 2011Assignee: Northwestern UniversityInventors: Tobin J. Marks, Antonio Facchetti
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Publication number: 20110112180Abstract: The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.Type: ApplicationFiled: September 10, 2008Publication date: May 12, 2011Applicant: Boston Biomedical, Inc.Inventors: Zhiwei Jiang, Chiang Jia Li, Wei Li, David Leggett
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Publication number: 20110062426Abstract: A process for the preparation of a substituted 2,2?-dithiophene is described, which process comprises the steps (a), (c) and optional steps (b) and (d): a reaction of a compound of the formula: with a suitable lithium organic compound, preferably Li-alkyl or Li-alkylamide; b) optional exchange of lithium against another metal selected from Mg1 Zn and Cu; c) reaction of the metallated intermediate obtained in step (a) or (b) with a suitable electrophil, which is CO2 or an aldehyde (addition reaction), or a compound Y?—R17 or Y?—R18-Z (substitution reaction), where R17 and R18 are as defined in claim 1; and optionally d) modification of the product obtained in step (c), e.g. by introducing one or more conjugating moieties Y ring closure between suitable monovalent residues R17, exchange or extension of functional groups or substituents such as addition to carbonyl or substitution of carbonyl in R17 or R18.Type: ApplicationFiled: March 6, 2009Publication date: March 17, 2011Applicant: BASF SEInventors: Hans Jurg Kirner, Frank Bienewald, Jean Charles Flores, Oliver Frédéric Aebischer
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Publication number: 20110002995Abstract: Provided is a pharmaceutical composition for the treatment and prevention of cardiac diseases, containing (a) a therapeutically effective amount of a compound represented by Formula 1 or 2 or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and (b) a pharmaceutically acceptable carrier, diluent or excipient or any combination thereof.Type: ApplicationFiled: December 18, 2008Publication date: January 6, 2011Applicants: MAZENCE INC., KT & G CORPORATIONInventors: Taehwan Kwak, Myung-Gyu Park
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Patent number: 7833693Abstract: The present application relates to a compound of formula A-X—B, where (i) A-X—B form an ionic compound Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula Q-R500—SO3? or (ii) A-X—B form a non-ionic compound Ac-Xc-Bc, where Ai, Bi, Q, R500, Ac, Bc, and Xc are defined herein. The compounds are useful as photoactive materials.Type: GrantFiled: December 10, 2008Date of Patent: November 16, 2010Inventors: M. Dalil Rahman, Francis M. Houlihan, Munirathna Padmanaban, SangHo Lee, Ralph R. Dammel, David Rentkiewicz, Clement Anyadiegwu
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Publication number: 20100256396Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.Type: ApplicationFiled: June 15, 2010Publication date: October 7, 2010Applicant: Sumitomo Chemical Company, LimitedInventors: Satoshi KOBAYASHI, Satoshi MIKAMI
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Publication number: 20100234609Abstract: Provided are a compound represented by Formula (I): wherein R1, R2, R3, and R4 are each independently selected from a hydrogen atom, a C1-6 alkyl group which may be substituted, a C7-14 aralkyl group which may be substituted and —C(?O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f). or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 27, 2007Publication date: September 16, 2010Inventors: Tsutomu Sato, Yoshihito Ohtake, Masahiro Nishimoto, Takashi Emura, Takamitsu Kobayashi, Marina Yamaguchi, Kyouko Takami
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Patent number: 7645791Abstract: Novel salicylic anilides are chemical uncouplers useful e.g. for the treatment of obesity.Type: GrantFiled: June 27, 2008Date of Patent: January 12, 2010Assignee: High Point Pharmaceuticals, LLCInventors: Preben Houlberg Olesen, Thomas Kruse Hansen, Lise Brown Christiansen, Holger Claus Hansen
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Publication number: 20090267061Abstract: Carbonyl-functionalized oligo/polythiophene compounds, and related semiconductor components and related device structures.Type: ApplicationFiled: April 29, 2009Publication date: October 29, 2009Inventors: Tobin J. Marks, Antonio Facchetti
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Publication number: 20090240014Abstract: Fluorinated compounds of the invention are represented by the following general formula (I). [In formula (I), Ar1 and Ar2 each independently represent a C10 or greater aromatic hydrocarbon or C4 or greater heterocyclic group, R1 represents hydrogen or a monovalent substituent, R2 and R3 each independently represent a monovalent substituent, and s1 and t1 each independently represent an integer of 0 or greater. When s1 is 2 or greater, the multiple R2 groups may be the same or different, and when t1 is 2 or greater the multiple R3 groups may be the same or different.Type: ApplicationFiled: February 22, 2007Publication date: September 24, 2009Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Yutaka Ie, Yoshio Aso, Masashi Nitani, Masato Ueda
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Publication number: 20090163723Abstract: Disclosed is a low cost, efficient method for production of a salt composed of an arylsulfonium and a fluorinated alkylfluorophosphate which method does not required a large excess amount of acid. The method comprises reacting an aryl compound Ar—H and with a compound represented by the formula (I), wherein R1 and R2 denote a hydrocarbon group or a heterocycle group which may be substituted, or they are bonded with each other directly or via —O—, —S—, —SO—, —SO2—, —NH—, —NR?—, —CO—, —COO—, —CONH—, an alkylene group having 1 to 3 carbon atoms or a phenylene group to form a ring structure which may be substituted, wherein R? denotes a C1-5 alkyl group or a C6-10 aryl group; in the presence of an acid represented by the formula (2), wherein Rf denotes an alkyl group 80% or more of whose hydrogen atoms are substituted by fluorine atoms, “a” is an integer of 1 to 5; and a dehydrating agent to produce the salt of sulfonium represented by the formula (3).Type: ApplicationFiled: November 24, 2006Publication date: June 25, 2009Inventors: Hideki Kimura, Jiro Yamamoto, Shinji Yamashita
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Patent number: 7521170Abstract: The present application relates to a compound of formula A-X—B, where (i)A-X—B form an ionic compound Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula Q-R500—SO3? or (ii)A-X—B form a non-ionic compound Ac-Xc-Bc, where Ai, Bi, Q, R500, Ac, Bc, and Xc are defined herein. The compounds are useful as photoactive materials.Type: GrantFiled: February 16, 2006Date of Patent: April 21, 2009Assignee: AZ Electronic Materials USA Corp.Inventors: M. Dalil Rahman, Francis M. Houlihan, Munirathna Padmanaban, SangHo Lee, Ralph R. Dammel, David Rentkiewicz, Clement Anyadiegwu
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Publication number: 20080312312Abstract: The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen Receptor beta mediated diseases such as benign prostatic hyperplasia.Type: ApplicationFiled: August 1, 2008Publication date: December 18, 2008Inventors: Gregory Lee Durst, Bryan Hurst Norman, Lance Allen Pfeifer, Timothy Ivo Richardson
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Patent number: 7442808Abstract: Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.Type: GrantFiled: May 11, 2007Date of Patent: October 28, 2008Assignee: Merck & Co., Inc.Inventors: Min Ge, Jiafang He, Fiona Wai Yu Lau, Gui-Bai Liang, Songnian Lin, Weiguo Liu, Shawn P. Walsh, Lihu Yang
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Patent number: 7390613Abstract: The present application relates to a compound of formula Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula ?O3S—CF2CF2OCF2CF2—SO3?. The compounds are useful as photoactive materials.Type: GrantFiled: December 4, 2006Date of Patent: June 24, 2008Assignee: AZ Electronic Materials USA Corp.Inventors: M. Dalil Rahman, David L. Rentkiewicz
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Publication number: 20080139824Abstract: There are disclosed novel compounds, liquid crystal compositions, polymers, optically anisotropic products, and optical or liquid or liquid crystal elements that have large refractive index anisotropy, mix easily with other liquid crystals, have advantageous stability against light, and exhibit absorption at practically short wavelength in the ultraviolet region. The compounds are represented by the formula (1) and have a phenylacetylene structure, wherein difference ?E in energy of HOMO of parts (1-1), (1-2) and (1-3) calculated by the method of molecular orbitals is not less than 0.3 electronvolt, and the polarizability anisotropy ?? of a molecule represented by the formula (1) calculated in the same way is not lower than 500 A.U.: (A1 to A4: H, F, alkyl or alkoxy group of C1 to C10 optionally substituted with F; P1, P2; structure fulfilling the conditions of HOMO energy and polarizability).Type: ApplicationFiled: November 20, 2007Publication date: June 12, 2008Inventors: Chizu Sekine, Masamitsu Ishitobi, Koichi Fujisawa, Kazunori Iwakura, Masayoshi Minai
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Patent number: 7384974Abstract: A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.Type: GrantFiled: July 30, 2004Date of Patent: June 10, 2008Assignee: Taisha Pharmaceutical Co., Ltd.Inventors: Minoru Taguchi, Ryo Suzuki, Ayako Mikami
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Patent number: 7332615Abstract: The present invention discloses hydrophilic derivatives of 4,8-dihydrobenzodithiophene-4,8-diones, which are active as anticancer agents, along with pharmaceutical formulations containing the same.Type: GrantFiled: September 28, 2005Date of Patent: February 19, 2008Assignees: Industrial Technology Research Institute, Yung Shin Pharm. Ind. Co., Ltd.Inventors: Pi-Tsan Huang, Yen-Fang Wen, Wuu-Chian Shin, Mei-Hwai Chen, Sheng-Chu Kuo, Kuo-Hsiung Lee
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Publication number: 20070265332Abstract: Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.Type: ApplicationFiled: May 11, 2007Publication date: November 15, 2007Inventors: Min Ge, Jiafang He, Fiona Wai Yu Lau, Gui-Bai Liang, Songnian Lin, Weiguo Liu, Shawn P. Walsh, Lihu Yang
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Patent number: 7101905Abstract: New fused thiophene compounds are provided and methods of using those compounds for a variety of therapeutic indications. Compounds of the invention are particularly useful for treatment of neuropathic pain.Type: GrantFiled: March 29, 2002Date of Patent: September 5, 2006Assignee: King Pharmaceuticals Research & Development, Inc.Inventors: Allan R. Moorman, Romeo Romagnoli, Pier Giovanni Baraldi
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Patent number: 6693136Abstract: Compounds of formula (I) are novel P2X3 and P2X2/P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.Type: GrantFiled: July 26, 2002Date of Patent: February 17, 2004Assignee: Abbott LaboratoriesInventors: Chih-Hung Lee, Meiqun Jiang, Richard A. Perner, Arthur Gomtsyan, Erol K. Bayburt, Guo Zhu Zheng
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Publication number: 20030229234Abstract: The present invention discloses a compound having the following formula (I), 1Type: ApplicationFiled: May 28, 2002Publication date: December 11, 2003Applicant: Everlight USA, Inc.Inventors: Chi-Sheng Chen, Yen-Cheng Li, Meng-Hsum Cheng
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Publication number: 20030225289Abstract: A process for the preparation of tricyclic amino alcohol derivatives including 2-[N-[2-(9H-carbazol-2-yloxy)ethyl]]amino-1-[(3-methylsulfonylamino)phenyl]ethanol useful in the treatment of diabetes, obesity, hyperlipidemia and so on; and intermediates as represented by formula (5) or (6) or the like useful in the preparation, wherein R11 is hydrogen or the like; and *1 represents an asymmetric carbon atom. 2-Halo-1-(3-nitrophenyl)ethanone derivatives and 1-(3-nitrophenyl)oxirane derivatives, which are intermediates for the preparation of tricyclic amino alcohol derivatives, are easy of purification, and particularly optically active 1-(3-nitrophenyl)oxirane derivatives are effective in enhancing the optical purities of the final products.Type: ApplicationFiled: June 11, 2003Publication date: December 4, 2003Applicant: ASAHI KASEI KABUSHIKI KAISHAInventors: Koki Matsubara, Naoyuki Ishii, Masami Ogawa
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Patent number: 6605632Abstract: The invention concerns compounds of formula (I): R—A—R′ wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R′ represents a —(CH2)t—R5 group wherein t and R5 are as defined in the descriptionType: GrantFiled: November 10, 2000Date of Patent: August 12, 2003Assignee: Les Laboratoires ServierInventors: Daniel Lesieur, Frédérique Klupsch, Gérald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renard, Philippe Delagrange
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Patent number: 6602901Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).Type: GrantFiled: April 13, 2001Date of Patent: August 5, 2003Assignee: Novo Nordisk A/SInventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
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Patent number: 6509499Abstract: The invention concerns novel compound of general formula (1) in which: P, T1, T2, X and n are as defined in claim 1, their tautomeric forms, and their additive salts with pharmaceutically acceptable bases. The invention also concerns methods for preparing these compounds and their applications as medicines. These compounds inhibit the aldose reductase enzyme and can be used in the treatment or prevention of peripheral and autonomous neurological diabetic complications, renal and ocular disorders such as cataract and retinopathy.Type: GrantFiled: March 17, 2000Date of Patent: January 21, 2003Assignee: Merck PatentGesellschaft mitInventors: François Collonges, Hervé Dumas, Claude Lardy, Philippe Durbin
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Publication number: 20020193611Abstract: Novel oligothiophenes and intermediates therefor are disclosed together with a process for synthesizing them. The oligothiophenes are in the form of a helix which contains five-membered rings unsaturated heterocycles that are cross-conjugated and annelated into a helix.Type: ApplicationFiled: May 22, 2001Publication date: December 19, 2002Inventor: Andrzej Rajca
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Publication number: 20020169164Abstract: Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.Type: ApplicationFiled: March 27, 2002Publication date: November 14, 2002Applicant: Warner-Lambert CompanyInventors: Patrick Michael O'Brien, Joseph Armand Picard, Drago Robert Sliskovic