Chalcogen Attached Directly To Ring Sulfur Of The Hetero Ring By Nonionic Bonding Patents (Class 549/46)
  • Patent number: 9156938
    Abstract: The present invention generally relates to compositions, methods, and systems comprising polymers that are fluorous-soluble and/or organize at interfaces between a fluorous phase and a non-fluorous phase. In some embodiments, emulsions or films are provided comprising a polymer. The polymers, emulsions, and films can be used in many applications, including for determining, treating, and/or imaging a condition and/or disease in a subject. The polymer may also be incorporated into various optoelectronic device such as photovoltaic cells, organic light-emitting diodes, organic field effect transistors, or the like. In some embodiments, the polymers comprise pi-conjugated backbones, and in some cases, are highly emissive.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: October 13, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Jeewoo Lim, Yohei Takeda
  • Patent number: 9040726
    Abstract: An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: May 26, 2015
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Gary L. Cantrell, Robert E. Halvachs, Kevin R. Roesch, Henry J. Buehler, Joseph P. Haar
  • Publication number: 20150090633
    Abstract: A method and a product made by treating a sulfur-containing hydrocarbon heavy feed, e.g., heavy crude asphaltene reduction is disposed herein. The method comprises the steps of: mixing the sulfur-containing hydrocarbon heavy feed with a hydrogen donor solvent and an addled silica to form a mixture and oxidizing the sulfur in the mixture at a temperature between 50° C. and 210° C. wherein the oxidation lowers the amount sulfur in the sulfur-containing hydrocarbon heavy feed by at least 90%.
    Type: Application
    Filed: December 2, 2014
    Publication date: April 2, 2015
    Inventors: Karina Castillo, Jason Parsons, Russell R. Chianelli
  • Publication number: 20150031896
    Abstract: The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 29, 2015
    Inventors: Horst Vestweber, Holger Heil, Philipp Stoessel, Arne Buesing, Amir Hossain Parham, Rocco Fortte
  • Patent number: 8871951
    Abstract: Hydrocarbon feedstocks are desulfurized by conversion of organosulfur compounds in a mixture of hydrocarbons into sulfoxides and/or sulfones. The oxidant used to promote oxidation of organosulfur-compounds is electrosynthesized in-situ.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: October 28, 2014
    Assignee: Saudi Arabian Oil Company
    Inventor: Emad Naji Al-Shafei
  • Publication number: 20130299811
    Abstract: The present invention provides an organic light-emitting device showing characteristics of high efficiency and long operating life. The organic light-emitting device includes an anode, a cathode, and an organic compound layer disposed between the anode and the cathode. The organic compound layer includes at least a light-emitting layer that contains a dibenzothiophene dioxide compound shown in claim 1.
    Type: Application
    Filed: December 9, 2011
    Publication date: November 14, 2013
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Masanori Seki, Kenichi Ikari
  • Publication number: 20130264245
    Abstract: A method and a product made by treating a sulfur-containing hydrocarbon heavy feed, e.g., heavy crude asphaltene reduction is disclosed herein. The method comprises the steps of: mixing the sulfur-containing hydrocarbon heavy feed with a hydrogen donor solvent and an acidified silica to form a mixture and oxidizing the sulfur in the mixture at a temperature between 50° C. and 210° C., wherein the oxidation lowers the amount sulfur in the sulfur-containing hydrocarbon heavy feed by at least 90%.
    Type: Application
    Filed: June 5, 2013
    Publication date: October 10, 2013
    Inventors: Karina Castillo, Jason Parsons, Russell R. Chianelli
  • Publication number: 20130053578
    Abstract: Hydrocarbon feedstocks are desulfurized by conversion of organosulfur compounds in a mixture of hydrocarbons into sulfoxides and/or sulfones. The oxidant used to promote oxidation of organosulfur-compounds is electrosynthesized in-situ.
    Type: Application
    Filed: July 27, 2012
    Publication date: February 28, 2013
    Inventor: Emad Naji Al-Shafei
  • Patent number: 8378340
    Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: February 19, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Satoshi Kobayashi, Satoshi Mikami
  • Publication number: 20120238765
    Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 20, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Satoshi KOBAYASHI, Satoshi Mikami
  • Publication number: 20110288066
    Abstract: The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.
    Type: Application
    Filed: February 9, 2010
    Publication date: November 24, 2011
    Applicant: MERCK SERONO S.A.
    Inventors: Stefano Crosignani, Catherine Jorand-Lebrun, Christophe Cleva, Adeline Pretre
  • Patent number: 8058550
    Abstract: This disclosure relates to a polymer that includes a first comonomer repeat unit containing a benzothiadiazole moiety, a thiophene oxide moiety, a cyclopentadithiophene oxide moiety, a thiadiazoloquinoxaline moiety, a benzoisothiazole moiety, a benzothiazole moiety, a thienothiophene moiety, a thienothiophene oxide moiety, a dithienothiophene moiety, a dithienothiophene oxide moiety, or a tetrahydroisoindole moiety. The polymer can be used as a photoactive material in a photovoltaic cell. This disclosure also relates to such photovoltaic cells, as well as modules containing such photovoltaic cells.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: November 15, 2011
    Assignee: Konarka Technologies, Inc.
    Inventors: Russell Gaudiana, Richard Kingsborough, Xiaobo Shi, David Waller, Zhengguo Zhu
  • Publication number: 20110082278
    Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 7, 2011
    Inventor: Mingqian He
  • Patent number: 7910653
    Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: March 22, 2011
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Patent number: 7893191
    Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: February 22, 2011
    Assignee: Corning Incorporated
    Inventor: Mingqian He
  • Patent number: 7868086
    Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: January 11, 2011
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Patent number: 7842822
    Abstract: The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen Receptor beta mediated diseases such as benign prostatic hyperplasia.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: November 30, 2010
    Assignee: Eli Lilly and Company
    Inventors: Gregory Lee Durst, Bryan Hurst Norman, Timothy Ivo Richardson
  • Patent number: 7838612
    Abstract: Described herein are aromatic sulfonimide compositions that can be used to prepare polymers useful as membranes in electrochemical cells.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 23, 2010
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Patent number: 7838594
    Abstract: Aromatic sulfonimide ionene compositions useful as monomers for polymers in electrochemical cells are prepared.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 23, 2010
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Mark F. Teasley
  • Publication number: 20100256396
    Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.
    Type: Application
    Filed: June 15, 2010
    Publication date: October 7, 2010
    Applicant: Sumitomo Chemical Company, Limited
    Inventors: Satoshi KOBAYASHI, Satoshi MIKAMI
  • Patent number: 7781673
    Abstract: This disclosure relates to a polymer containing a first comonomer repeat unit and a second comonomer repeat unit. The first comonomer repeat unit includes a cyclopentadithiophene moiety. The second comonomer repeat unit includes a thienothiophene moiety, a thienothiophene tetraoxide moiety, a dithienothiophene moiety, a dithienothiophene dioxide moiety, a dithienothiophene tetraoxide moiety, or a tetrahydroisoindole moiety. The polymer can be used as a photoactive material in a photovoltaic cell. This disclosure also relates to such photovoltaic cells, as well as modules containing such photovoltaic cells.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: August 24, 2010
    Assignee: Konarka Technologies, Inc.
    Inventors: Russell Gaudiana, Richard Kingsborough, David Waller, Zhengguo Zhu
  • Publication number: 20100136478
    Abstract: A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the acid-generator component (B) including an acid generator (B1) containing a compound having a cation moiety represented by general formula (I) (in the formula, R5 represents an organic group having a carbonyl group, an ester bond or a sulfonyl group; and Q represents a divalent linking group).
    Type: Application
    Filed: November 25, 2009
    Publication date: June 3, 2010
    Inventors: Akiya Kawaue, Yoshiyuki Utsumi, Hideo Hada, Takehiro Seshimo, Kensuke Matsuzawa, Keita Ishiduka, Kotaro Endo
  • Publication number: 20100010237
    Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof
    Type: Application
    Filed: September 17, 2009
    Publication date: January 14, 2010
    Inventor: Mingqian He
  • Publication number: 20090298925
    Abstract: The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen Receptor beta mediated diseases such as benign prostatic hyperplasia.
    Type: Application
    Filed: July 31, 2009
    Publication date: December 3, 2009
    Inventors: Gregory Lee Durst, Bryan Hurst Norman, Lance Allen Pfeifer, Timothy Ivo Richardson
  • Patent number: 7514127
    Abstract: The present invention relates to compounds of the formula I where Y, X1, X2, X3, R1, R2, A1, A2, Z1, Z2, m and n are as defined in Claim 1, to the use thereof as components in liquid-crystalline media, and to electro-optical display elements containing the liquid-crystalline media according to the invention.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: April 7, 2009
    Assignee: Merck Patent GmbH
    Inventors: Lars Lietzau, Matthias Bremer, Melanie Klasen-Memmer
  • Patent number: 7476691
    Abstract: The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R1, R2, R3, m and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these compounds and to methods of using them.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: January 13, 2009
    Assignee: Laboratoire Theramex
    Inventors: Jean Lafay, Benoît Rondot, Denis Carniato, Paule Bonnet, Thierry Clerc, Jacqueline Shields, Igor Duc, Eric Duranti
  • Publication number: 20080220285
    Abstract: The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.
    Type: Application
    Filed: April 21, 2006
    Publication date: September 11, 2008
    Applicant: Merck Patent GmbH
    Inventors: Horst Vestweber, Holger Heil, Philipp Stoessel, Arne Buesing, Amir Hossain Parham, Rocco Fortte
  • Patent number: 7390613
    Abstract: The present application relates to a compound of formula Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula ?O3S—CF2CF2OCF2CF2—SO3?. The compounds are useful as photoactive materials.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: June 24, 2008
    Assignee: AZ Electronic Materials USA Corp.
    Inventors: M. Dalil Rahman, David L. Rentkiewicz
  • Publication number: 20080146810
    Abstract: The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes.
    Type: Application
    Filed: June 27, 2007
    Publication date: June 19, 2008
    Applicant: GLENMARK PHARMACEUTICALS S.A.
    Inventors: Gopalan Balasubramanian, Laxmikant A. Gharat, Aftab D. Lakdawala, Raghu R. Anupindi
  • Patent number: 7332492
    Abstract: Compounds of formula (I): wherein: X is a group of formula (B): and R1, R2, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: February 19, 2008
    Assignee: AstraZeneca AB
    Inventors: Michael Howard Block, Kevin Michael Foote
  • Patent number: 7135579
    Abstract: There are disclosed novel compounds, liquid crystal compositions, polymers, optically anisotropic producgs, and optical or liquid crystal elements that have large refractive index anisotropy, mix easily with other liquid crystals, have advantageous stability against light, and exhibit absorption at practically short wavelength in the ultraviolet region. The compounds are represented by the formula (1) and have a phenylacetylene structure, wherein difference ?E in energy of HOMO of parts (1-1), (1-2) and (1-3) calculated by the method of molecular orbitals is not less than 0.3 electronvolt, and the polarizability anisotropy ?? of a molecule represented by the formula (1) calculated in the same way is not lower than 500 A.U.: P1—H??(1-2) P2—H??(1-3) (A1 to A4: H, F, alkyl or alkoxy group of C1 to C10 optionally substituted with F; P1, P2: structure fulfilling the conditions of HOMO energy and polarizability).
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: November 14, 2006
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Chizu Sekine, Masamitsu Ishitobi, Koichi Fujisawa, Kazunori Iwakura, Masayoshi Minai
  • Patent number: 6916938
    Abstract: There is provided a method for preparing a sulfone or sulfoxide compound, characterized in that a sulfide compound is allowed to react with hydrogen peroxide in the presence of a metal oxide catalyst formed by the reaction of hydrogen peroxide with at least one metal or metal compound selected from tungsten metal; molybdenum metal; a tungsten compound comprising tungsten and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen; and a molybdenum compound comprising molybdenum and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: July 12, 2005
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Jun Oguma, Koji Hagiya, Takashi Miyawaki
  • Patent number: 6818260
    Abstract: The invention relates to new thienothiophene derivatives, their use as semiconductors or charge transport materials, in optical, electrooptical or electronic devices like for example organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in photovoltaic and sensor devices, and to a field effect transistor, light emitting device or ID tag comprising the thienothiophene derivatives.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: November 16, 2004
    Assignee: Merck Patent GmbH
    Inventors: Louise Farrand, Marcus Thompson, Mark Giles, Martin Heeney, Steven Tierney, Maxim Shkunov, David Sparrowe, Iain McCulloch
  • Patent number: 6693136
    Abstract: Compounds of formula (I) are novel P2X3 and P2X2/P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: February 17, 2004
    Assignee: Abbott Laboratories
    Inventors: Chih-Hung Lee, Meiqun Jiang, Richard A. Perner, Arthur Gomtsyan, Erol K. Bayburt, Guo Zhu Zheng
  • Publication number: 20030171589
    Abstract: There is provided a method for preparing a sulfone or sulfoxide compound, characterized in that a sulfide compound is allowed to react with hydrogen peroxide in the presence of a metal oxide catalyst formed by the reaction of hydrogen peroxide with at least one metal or metal compound selected from tungsten metal; molybdenum metal; a tungsten compound comprising tungsten and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen; and a molybdenum compound comprising molybdenum and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen.
    Type: Application
    Filed: January 23, 2003
    Publication date: September 11, 2003
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Jun Oguma, Koji Hagiya, Takashi Miyawaki
  • Patent number: 6605632
    Abstract: The invention concerns compounds of formula (I): R—A—R′ wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R′ represents a —(CH2)t—R5 group wherein t and R5 are as defined in the description
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: August 12, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Frédérique Klupsch, Gérald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renard, Philippe Delagrange
  • Patent number: 6353018
    Abstract: The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: March 5, 2002
    Assignees: Novo Nordisk A/S, Dr. Reddy's Research Foundation
    Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
  • Patent number: 6245255
    Abstract: A dispersion comprises a solvent having dispersed therein a liquid-crystal forming dye of structural Formula I, II or III: wherein the substituent are as defined in the specification. The dispersion is particularly useful in imaging and photographic elements.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: June 12, 2001
    Assignee: Eastman Kodak Company
    Inventors: Margaret J. Helber, William J. Harrison, Kevin W. Williams, Steven W. Kortum
  • Patent number: 6221889
    Abstract: This invention provides for a method of treating a chemokine mediated disease, wherein the chemokine is one which binds to an IL-8 &agr; or &bgr; receptor and which method comprises administering an effective amount of a compound of Formular (I) or a pharmaceuticlly acceptable salt thereof. In particular the chemokine is IL-8.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Melvin C. Rutledge, Jr., Katherine L. Widdowson
  • Patent number: 6022307
    Abstract: The invention provides novel substituted dibenzothiophenes of Formulae (I), (II), (III) and (IV) which have antiangiogenic activity and further provides a method using substituted dibenzothiophenes of Formula (V) as antiangiogenic agents.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: February 8, 2000
    Assignee: American Cyanamid Company
    Inventors: Mark E. Salvati, Nancy H. Eudy, William A. Hallett, Dennis William Powell
  • Patent number: 6001867
    Abstract: This invention provides compounds of Formula I having the structure ##STR1## wherein: B and D are each, independently, hydrogen, halogen, --CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms;X is H, or halogen;R.sup.1 is hydrogen, alkyl of 1-6 carbon atoms, --CH(R.sup.2)W, --C(CH.sub.3).sub.2 CO.sub.2 R.sup.3, 5-thiazolidine-2,4-dione, --CH(R.sup.4)CH.sub.2 CO.sub.2 R.sup.3, --COR.sup.3, or --PO.sub.3 (R.sup.3).sub.2 ;R.sup.2 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, aryl, --CH.sub.2 (1H-imidazol-4-yl), --CH.sub.2 (3-1H-indolyl), --CH.sub.2 CH.sub.2 (1,3-dioxo-1,3-dihydro-isoindol-2-yl), --CH.sub.2 CH.sub.2 (1-oxo-1,3-dihydro-isoindol-2-yl), or --CH.sub.2 (3-pyridyl);W is --CO.sub.2 R.sup.3, --CONH.sub.2, --CONHOH, --CN, --CONH(CH.sub.2).sub.2 CN, 5-tetrazole, or --PO.sub.3 (R.sup.3).sub.2 ;R.sup.3 is hydrogen, alkyl of 1-6 carbon atoms, or aryl;R.sup.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: December 14, 1999
    Assignee: American Home Products Corporation
    Inventors: Jay E. Wrobel, Arlene J. Dietrich, Zenan Li
  • Patent number: 5990104
    Abstract: Polycyclic alkaloids of formula (I), wherein R.sub.1 is H, C.sub.1-6 alkyl, or C.sub.6-12 aryl optionally substituted with polar groups; R.sub.2 and R.sub.3 are independently H, OH, C.sub.1-6 alkyl, --C(NH)--NH.sub.2, a positively charged group, or C.sub.7-13 aralkyl optionally substituted with NH.sub.2, OH, C.sub.1-6 alkyl, or halogen; or R.sub.2 and R.sub.3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R.sub.4 is H, C.sub.1-6 alkyl, OR.sub.6, SR.sub.6, or N(R.sub.6).sub.2, wherein each R.sub.6 is independently H, C.sub.1-3 alkyl; X ix O, S, SO, SO.sub.2, or N--R.sub.5, wherein each R.sub.5 is independently H, C.sub.1-6 alkyl, or C.sub.7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; and m is an integer from 0 to 3. These compounds act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: November 23, 1999
    Assignee: Biochem Pharma, Inc.
    Inventors: John Dimaio, Dilip M. Dixit
  • Patent number: 5726208
    Abstract: New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers,and their addition salts with pharmaceutically acceptable acids.Those compounds may be used as medicaments.
    Type: Grant
    Filed: October 11, 1996
    Date of Patent: March 10, 1998
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Bertrand Goument, Jean-Christophe Harmange, Joel Vian, Aimee Dessinges, Mark Millan, Valerie Audinot
  • Patent number: 5607624
    Abstract: A process for the preparation of compounds of formula I ##STR1## wherein the general symbols are as defined in claim 1, which comprises reacting a compound of formula III ##STR2## wherein the general symbols are as defined in claim 1, with a compound of formula IV[H].sub.n --R.sub.1 (IV).
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: March 4, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Nesvadba, Samuel Evans, Ralf Schmitt
  • Patent number: 5463082
    Abstract: Stoichiometric and catalytic chemical transformations may be carried out in solution using novel fluorous multiphase systems (FMS). The term "fluorous" is defined as a carbon-fluorine bond rich organic molecule. The FMS consists of a fluorous phase containing a fluorous solvent, typically a fluorocarbon or a fluorohydrocarbon and a reagent or a catalyst containing a sufficient number of fluorous moieties to render it preferentially soluble in the fluorous solvent without impairing the ability of the catalyst or reagent to be effective in the reaction and while maintaining the reaction in a liquid or fluid phase. The nonfluorous solvent may be any suitable organic or nonorganic solvent(s) with limited or no solubility in the fluorous solvent that is effective for dissolving the reactant(s) and most desirably, for separating the resulting product(s). Typically, such solvents have a Hildebrand solubility parameter of at least about 18.0 MPa1/2.
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: October 31, 1995
    Assignee: Exxon Research and Engineering Company
    Inventors: Istvan T. Horvath, Jozsef Rabai
  • Patent number: 5338821
    Abstract: Benzofuran-ether-sulphone monomers of formula ##STR1## and ether ketone polymers derived therefrom of formula ##STR2##
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: August 16, 1994
    Assignee: Raychem Limited
    Inventor: Ian D. H. Towle
  • Patent number: 5294522
    Abstract: A novel photochromic compound as a photoreactive material making use of photochromism is provided, which compound is expressed by the following formula (1) or (2)): ##STR1## wherein R is alkyl, alkoxy, perfluoroalkyl or cyano; X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and X.sub.6 are each H, halogen, alkyl, alkoxy, cyano, alkanoyloxy or alkyloxycarbonyl, or a substituted or unsubstituted benzene ring is formed by condensation between at adjacent groups among X.sub.1 to X.sub.6 ; Y is Y.sub.1 C=CY.sub.2, O, S, SO, SO.sub.2 or NY.sub.3 wherein Y.sub.1 and Y.sub.2 are each as defined in the case of the above X.sub.1 to X.sub.6 and Y.sub.3 is H, alkyl, alkanoyl, alkyloxycarbonyl or aryl; and the symbol refers to occurrence of E- or Z-isomer, and which compound is useful as rewritable optical memory element or photo-display element and also as solar energy-storage material, duplicating material, masking material, optical filter, toys, etc.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: March 15, 1994
    Assignee: Chisso Corporation
    Inventors: Manabu Uchida, Masahiro Irie
  • Patent number: 5208259
    Abstract: The invention concerns a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl;X.sup.1 is oxy, thio, sulphinyl or sulphonyl;Ar.sup.2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 is (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- wherein each of A.sup.2 and A.sup.3 is (1-4C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino.The invention also concerns processes for the manufacture of a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said heterocycle. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
    Type: Grant
    Filed: July 3, 1990
    Date of Patent: May 4, 1993
    Assignees: Imperial Chemical Industries, ICI Pharma
    Inventors: Thomas G. C. Bird, Philip N. Edwards
  • Patent number: 4965284
    Abstract: This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.
    Type: Grant
    Filed: April 25, 1989
    Date of Patent: October 23, 1990
    Assignee: American Cyanamid Company
    Inventors: Vijay G. Nair, Ramson B. Conrow, Bosco S. Wang, V. M. Ruszala-Mallon
  • Patent number: 4797414
    Abstract: Pharmaceutical preparations containing compounds of formula I ##STR1## wherein ring A is unsubstituted or substituted, R.sub.1 and R.sub.2, independently of one another, each represents hydrogen, lower alkyl, aryl or heteroaryl, or R.sub.1 and R.sub.2 together represent lower alkylene optionally interrupted by oxygen, sulfur or optionally substituted nitrogen, Y is methylene, methylene mono- or disubstituted by lower alkyl, oxygen, sulfur, sulfinyl or sulfonyl, X represents a bivalent radical --S--C[--B--(Z).sub.n ].dbd.CH-- the sulfur group S of which is bonded directly to the .alpha.- or to the .beta.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: January 10, 1989
    Assignee: Zyma SA
    Inventor: Christian G. Rimbault