Chalcogen Attached Directly To Ring Sulfur Of The Hetero Ring By Nonionic Bonding Patents (Class 549/46)
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Patent number: 11219215Abstract: The present invention relates to a herbicidal composition comprising specific inhibitors of protoporphyrinogen oxidase (PPO inhibitors) selected from flumioxazin and sulfentrazone. The invention also relates to methods and uses for controlling undesirable vegetation, in particular in crops.Type: GrantFiled: March 22, 2019Date of Patent: January 11, 2022Assignee: BASF AGRO B.V.Inventors: Helmut Kraus, Bernd Sievernich, Mariano Etcheverry, Richard R. Evans, Ryan Louis Nielson, Cyrill Zagar, Rex A. Liebl
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Patent number: 9156938Abstract: The present invention generally relates to compositions, methods, and systems comprising polymers that are fluorous-soluble and/or organize at interfaces between a fluorous phase and a non-fluorous phase. In some embodiments, emulsions or films are provided comprising a polymer. The polymers, emulsions, and films can be used in many applications, including for determining, treating, and/or imaging a condition and/or disease in a subject. The polymer may also be incorporated into various optoelectronic device such as photovoltaic cells, organic light-emitting diodes, organic field effect transistors, or the like. In some embodiments, the polymers comprise pi-conjugated backbones, and in some cases, are highly emissive.Type: GrantFiled: August 19, 2011Date of Patent: October 13, 2015Assignee: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Jeewoo Lim, Yohei Takeda
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Patent number: 9040726Abstract: An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.Type: GrantFiled: September 3, 2009Date of Patent: May 26, 2015Assignee: Mallinckrodt LLCInventors: Peter X. Wang, Gary L. Cantrell, Robert E. Halvachs, Kevin R. Roesch, Henry J. Buehler, Joseph P. Haar
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Publication number: 20150090633Abstract: A method and a product made by treating a sulfur-containing hydrocarbon heavy feed, e.g., heavy crude asphaltene reduction is disposed herein. The method comprises the steps of: mixing the sulfur-containing hydrocarbon heavy feed with a hydrogen donor solvent and an addled silica to form a mixture and oxidizing the sulfur in the mixture at a temperature between 50° C. and 210° C. wherein the oxidation lowers the amount sulfur in the sulfur-containing hydrocarbon heavy feed by at least 90%.Type: ApplicationFiled: December 2, 2014Publication date: April 2, 2015Inventors: Karina Castillo, Jason Parsons, Russell R. Chianelli
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Publication number: 20150031896Abstract: The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.Type: ApplicationFiled: October 2, 2014Publication date: January 29, 2015Inventors: Horst Vestweber, Holger Heil, Philipp Stoessel, Arne Buesing, Amir Hossain Parham, Rocco Fortte
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Patent number: 8871951Abstract: Hydrocarbon feedstocks are desulfurized by conversion of organosulfur compounds in a mixture of hydrocarbons into sulfoxides and/or sulfones. The oxidant used to promote oxidation of organosulfur-compounds is electrosynthesized in-situ.Type: GrantFiled: July 27, 2012Date of Patent: October 28, 2014Assignee: Saudi Arabian Oil CompanyInventor: Emad Naji Al-Shafei
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Publication number: 20130299811Abstract: The present invention provides an organic light-emitting device showing characteristics of high efficiency and long operating life. The organic light-emitting device includes an anode, a cathode, and an organic compound layer disposed between the anode and the cathode. The organic compound layer includes at least a light-emitting layer that contains a dibenzothiophene dioxide compound shown in claim 1.Type: ApplicationFiled: December 9, 2011Publication date: November 14, 2013Applicant: CANON KABUSHIKI KAISHAInventors: Masanori Seki, Kenichi Ikari
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Publication number: 20130264245Abstract: A method and a product made by treating a sulfur-containing hydrocarbon heavy feed, e.g., heavy crude asphaltene reduction is disclosed herein. The method comprises the steps of: mixing the sulfur-containing hydrocarbon heavy feed with a hydrogen donor solvent and an acidified silica to form a mixture and oxidizing the sulfur in the mixture at a temperature between 50° C. and 210° C., wherein the oxidation lowers the amount sulfur in the sulfur-containing hydrocarbon heavy feed by at least 90%.Type: ApplicationFiled: June 5, 2013Publication date: October 10, 2013Inventors: Karina Castillo, Jason Parsons, Russell R. Chianelli
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Publication number: 20130053578Abstract: Hydrocarbon feedstocks are desulfurized by conversion of organosulfur compounds in a mixture of hydrocarbons into sulfoxides and/or sulfones. The oxidant used to promote oxidation of organosulfur-compounds is electrosynthesized in-situ.Type: ApplicationFiled: July 27, 2012Publication date: February 28, 2013Inventor: Emad Naji Al-Shafei
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Patent number: 8378340Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.Type: GrantFiled: June 4, 2012Date of Patent: February 19, 2013Assignee: Sumitomo Chemical Company, LimitedInventors: Satoshi Kobayashi, Satoshi Mikami
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Publication number: 20120238765Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.Type: ApplicationFiled: June 4, 2012Publication date: September 20, 2012Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Satoshi KOBAYASHI, Satoshi Mikami
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Publication number: 20110288066Abstract: The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.Type: ApplicationFiled: February 9, 2010Publication date: November 24, 2011Applicant: MERCK SERONO S.A.Inventors: Stefano Crosignani, Catherine Jorand-Lebrun, Christophe Cleva, Adeline Pretre
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Patent number: 8058550Abstract: This disclosure relates to a polymer that includes a first comonomer repeat unit containing a benzothiadiazole moiety, a thiophene oxide moiety, a cyclopentadithiophene oxide moiety, a thiadiazoloquinoxaline moiety, a benzoisothiazole moiety, a benzothiazole moiety, a thienothiophene moiety, a thienothiophene oxide moiety, a dithienothiophene moiety, a dithienothiophene oxide moiety, or a tetrahydroisoindole moiety. The polymer can be used as a photoactive material in a photovoltaic cell. This disclosure also relates to such photovoltaic cells, as well as modules containing such photovoltaic cells.Type: GrantFiled: July 13, 2006Date of Patent: November 15, 2011Assignee: Konarka Technologies, Inc.Inventors: Russell Gaudiana, Richard Kingsborough, Xiaobo Shi, David Waller, Zhengguo Zhu
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Publication number: 20110082278Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.Type: ApplicationFiled: October 15, 2010Publication date: April 7, 2011Inventor: Mingqian He
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Patent number: 7910653Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.Type: GrantFiled: October 1, 2007Date of Patent: March 22, 2011Assignee: E.I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Patent number: 7893191Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.Type: GrantFiled: September 17, 2009Date of Patent: February 22, 2011Assignee: Corning IncorporatedInventor: Mingqian He
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Patent number: 7868086Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.Type: GrantFiled: October 1, 2007Date of Patent: January 11, 2011Assignee: E. I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Patent number: 7842822Abstract: The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen Receptor beta mediated diseases such as benign prostatic hyperplasia.Type: GrantFiled: July 31, 2009Date of Patent: November 30, 2010Assignee: Eli Lilly and CompanyInventors: Gregory Lee Durst, Bryan Hurst Norman, Timothy Ivo Richardson
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Patent number: 7838594Abstract: Aromatic sulfonimide ionene compositions useful as monomers for polymers in electrochemical cells are prepared.Type: GrantFiled: October 1, 2007Date of Patent: November 23, 2010Assignee: E.I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Patent number: 7838612Abstract: Described herein are aromatic sulfonimide compositions that can be used to prepare polymers useful as membranes in electrochemical cells.Type: GrantFiled: October 1, 2007Date of Patent: November 23, 2010Assignee: E. I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Publication number: 20100256396Abstract: An aromatic compound of the following formula (1), (2), (5) or (6), wherein, Ar1 and Ar3 represent a tetra-valent aromatic hydrocarbon group or a tetra-valent heterocyclic group, and Ar2, Ar4, Ar5, Ar6 and Ar7 represent a tri-valent aromatic hydrocarbon group or a tri-valent heterocyclic group, A1 represents —Z1—, —Z2—Z3— or —Z4?Z5—, wherein Z1, Z2 and Z3 represent O, S or the like and Z4 and Z5 represent N, B, P or the like, X1, X2, X3, X4, X9, X10, X11, and X12 represent a halogen atom or the like.Type: ApplicationFiled: June 15, 2010Publication date: October 7, 2010Applicant: Sumitomo Chemical Company, LimitedInventors: Satoshi KOBAYASHI, Satoshi MIKAMI
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Patent number: 7781673Abstract: This disclosure relates to a polymer containing a first comonomer repeat unit and a second comonomer repeat unit. The first comonomer repeat unit includes a cyclopentadithiophene moiety. The second comonomer repeat unit includes a thienothiophene moiety, a thienothiophene tetraoxide moiety, a dithienothiophene moiety, a dithienothiophene dioxide moiety, a dithienothiophene tetraoxide moiety, or a tetrahydroisoindole moiety. The polymer can be used as a photoactive material in a photovoltaic cell. This disclosure also relates to such photovoltaic cells, as well as modules containing such photovoltaic cells.Type: GrantFiled: June 9, 2006Date of Patent: August 24, 2010Assignee: Konarka Technologies, Inc.Inventors: Russell Gaudiana, Richard Kingsborough, David Waller, Zhengguo Zhu
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Publication number: 20100136478Abstract: A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the acid-generator component (B) including an acid generator (B1) containing a compound having a cation moiety represented by general formula (I) (in the formula, R5 represents an organic group having a carbonyl group, an ester bond or a sulfonyl group; and Q represents a divalent linking group).Type: ApplicationFiled: November 25, 2009Publication date: June 3, 2010Inventors: Akiya Kawaue, Yoshiyuki Utsumi, Hideo Hada, Takehiro Seshimo, Kensuke Matsuzawa, Keita Ishiduka, Kotaro Endo
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Publication number: 20100010237Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereofType: ApplicationFiled: September 17, 2009Publication date: January 14, 2010Inventor: Mingqian He
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Publication number: 20090298925Abstract: The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen Receptor beta mediated diseases such as benign prostatic hyperplasia.Type: ApplicationFiled: July 31, 2009Publication date: December 3, 2009Inventors: Gregory Lee Durst, Bryan Hurst Norman, Lance Allen Pfeifer, Timothy Ivo Richardson
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Patent number: 7514127Abstract: The present invention relates to compounds of the formula I where Y, X1, X2, X3, R1, R2, A1, A2, Z1, Z2, m and n are as defined in Claim 1, to the use thereof as components in liquid-crystalline media, and to electro-optical display elements containing the liquid-crystalline media according to the invention.Type: GrantFiled: March 18, 2005Date of Patent: April 7, 2009Assignee: Merck Patent GmbHInventors: Lars Lietzau, Matthias Bremer, Melanie Klasen-Memmer
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Patent number: 7476691Abstract: The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R1, R2, R3, m and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these compounds and to methods of using them.Type: GrantFiled: May 16, 2003Date of Patent: January 13, 2009Assignee: Laboratoire TheramexInventors: Jean Lafay, Benoît Rondot, Denis Carniato, Paule Bonnet, Thierry Clerc, Jacqueline Shields, Igor Duc, Eric Duranti
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Publication number: 20080220285Abstract: The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.Type: ApplicationFiled: April 21, 2006Publication date: September 11, 2008Applicant: Merck Patent GmbHInventors: Horst Vestweber, Holger Heil, Philipp Stoessel, Arne Buesing, Amir Hossain Parham, Rocco Fortte
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Patent number: 7390613Abstract: The present application relates to a compound of formula Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula ?O3S—CF2CF2OCF2CF2—SO3?. The compounds are useful as photoactive materials.Type: GrantFiled: December 4, 2006Date of Patent: June 24, 2008Assignee: AZ Electronic Materials USA Corp.Inventors: M. Dalil Rahman, David L. Rentkiewicz
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Publication number: 20080146810Abstract: The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes.Type: ApplicationFiled: June 27, 2007Publication date: June 19, 2008Applicant: GLENMARK PHARMACEUTICALS S.A.Inventors: Gopalan Balasubramanian, Laxmikant A. Gharat, Aftab D. Lakdawala, Raghu R. Anupindi
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Patent number: 7332492Abstract: Compounds of formula (I): wherein: X is a group of formula (B): and R1, R2, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described.Type: GrantFiled: May 12, 2005Date of Patent: February 19, 2008Assignee: AstraZeneca ABInventors: Michael Howard Block, Kevin Michael Foote
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Patent number: 7135579Abstract: There are disclosed novel compounds, liquid crystal compositions, polymers, optically anisotropic producgs, and optical or liquid crystal elements that have large refractive index anisotropy, mix easily with other liquid crystals, have advantageous stability against light, and exhibit absorption at practically short wavelength in the ultraviolet region. The compounds are represented by the formula (1) and have a phenylacetylene structure, wherein difference ?E in energy of HOMO of parts (1-1), (1-2) and (1-3) calculated by the method of molecular orbitals is not less than 0.3 electronvolt, and the polarizability anisotropy ?? of a molecule represented by the formula (1) calculated in the same way is not lower than 500 A.U.: P1—H??(1-2) P2—H??(1-3) (A1 to A4: H, F, alkyl or alkoxy group of C1 to C10 optionally substituted with F; P1, P2: structure fulfilling the conditions of HOMO energy and polarizability).Type: GrantFiled: June 23, 2004Date of Patent: November 14, 2006Assignee: Sumitomo Chemical Company, LimitedInventors: Chizu Sekine, Masamitsu Ishitobi, Koichi Fujisawa, Kazunori Iwakura, Masayoshi Minai
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Patent number: 6916938Abstract: There is provided a method for preparing a sulfone or sulfoxide compound, characterized in that a sulfide compound is allowed to react with hydrogen peroxide in the presence of a metal oxide catalyst formed by the reaction of hydrogen peroxide with at least one metal or metal compound selected from tungsten metal; molybdenum metal; a tungsten compound comprising tungsten and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen; and a molybdenum compound comprising molybdenum and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen.Type: GrantFiled: January 23, 2003Date of Patent: July 12, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Jun Oguma, Koji Hagiya, Takashi Miyawaki
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Patent number: 6818260Abstract: The invention relates to new thienothiophene derivatives, their use as semiconductors or charge transport materials, in optical, electrooptical or electronic devices like for example organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in photovoltaic and sensor devices, and to a field effect transistor, light emitting device or ID tag comprising the thienothiophene derivatives.Type: GrantFiled: July 9, 2002Date of Patent: November 16, 2004Assignee: Merck Patent GmbHInventors: Louise Farrand, Marcus Thompson, Mark Giles, Martin Heeney, Steven Tierney, Maxim Shkunov, David Sparrowe, Iain McCulloch
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Patent number: 6693136Abstract: Compounds of formula (I) are novel P2X3 and P2X2/P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.Type: GrantFiled: July 26, 2002Date of Patent: February 17, 2004Assignee: Abbott LaboratoriesInventors: Chih-Hung Lee, Meiqun Jiang, Richard A. Perner, Arthur Gomtsyan, Erol K. Bayburt, Guo Zhu Zheng
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Publication number: 20030171589Abstract: There is provided a method for preparing a sulfone or sulfoxide compound, characterized in that a sulfide compound is allowed to react with hydrogen peroxide in the presence of a metal oxide catalyst formed by the reaction of hydrogen peroxide with at least one metal or metal compound selected from tungsten metal; molybdenum metal; a tungsten compound comprising tungsten and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen; and a molybdenum compound comprising molybdenum and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen.Type: ApplicationFiled: January 23, 2003Publication date: September 11, 2003Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Jun Oguma, Koji Hagiya, Takashi Miyawaki
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Patent number: 6605632Abstract: The invention concerns compounds of formula (I): R—A—R′ wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R′ represents a —(CH2)t—R5 group wherein t and R5 are as defined in the descriptionType: GrantFiled: November 10, 2000Date of Patent: August 12, 2003Assignee: Les Laboratoires ServierInventors: Daniel Lesieur, Frédérique Klupsch, Gérald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renard, Philippe Delagrange
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Patent number: 6353018Abstract: The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).Type: GrantFiled: October 19, 1999Date of Patent: March 5, 2002Assignees: Novo Nordisk A/S, Dr. Reddy's Research FoundationInventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
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Patent number: 6245255Abstract: A dispersion comprises a solvent having dispersed therein a liquid-crystal forming dye of structural Formula I, II or III: wherein the substituent are as defined in the specification. The dispersion is particularly useful in imaging and photographic elements.Type: GrantFiled: May 23, 2000Date of Patent: June 12, 2001Assignee: Eastman Kodak CompanyInventors: Margaret J. Helber, William J. Harrison, Kevin W. Williams, Steven W. Kortum
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Patent number: 6221889Abstract: This invention provides for a method of treating a chemokine mediated disease, wherein the chemokine is one which binds to an IL-8 &agr; or &bgr; receptor and which method comprises administering an effective amount of a compound of Formular (I) or a pharmaceuticlly acceptable salt thereof. In particular the chemokine is IL-8.Type: GrantFiled: July 14, 2000Date of Patent: April 24, 2001Assignee: SmithKline Beecham CorporationInventors: Melvin C. Rutledge, Jr., Katherine L. Widdowson
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Patent number: 6022307Abstract: The invention provides novel substituted dibenzothiophenes of Formulae (I), (II), (III) and (IV) which have antiangiogenic activity and further provides a method using substituted dibenzothiophenes of Formula (V) as antiangiogenic agents.Type: GrantFiled: June 28, 1999Date of Patent: February 8, 2000Assignee: American Cyanamid CompanyInventors: Mark E. Salvati, Nancy H. Eudy, William A. Hallett, Dennis William Powell
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Patent number: 6001867Abstract: This invention provides compounds of Formula I having the structure ##STR1## wherein: B and D are each, independently, hydrogen, halogen, --CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms;X is H, or halogen;R.sup.1 is hydrogen, alkyl of 1-6 carbon atoms, --CH(R.sup.2)W, --C(CH.sub.3).sub.2 CO.sub.2 R.sup.3, 5-thiazolidine-2,4-dione, --CH(R.sup.4)CH.sub.2 CO.sub.2 R.sup.3, --COR.sup.3, or --PO.sub.3 (R.sup.3).sub.2 ;R.sup.2 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, aryl, --CH.sub.2 (1H-imidazol-4-yl), --CH.sub.2 (3-1H-indolyl), --CH.sub.2 CH.sub.2 (1,3-dioxo-1,3-dihydro-isoindol-2-yl), --CH.sub.2 CH.sub.2 (1-oxo-1,3-dihydro-isoindol-2-yl), or --CH.sub.2 (3-pyridyl);W is --CO.sub.2 R.sup.3, --CONH.sub.2, --CONHOH, --CN, --CONH(CH.sub.2).sub.2 CN, 5-tetrazole, or --PO.sub.3 (R.sup.3).sub.2 ;R.sup.3 is hydrogen, alkyl of 1-6 carbon atoms, or aryl;R.sup.Type: GrantFiled: May 10, 1999Date of Patent: December 14, 1999Assignee: American Home Products CorporationInventors: Jay E. Wrobel, Arlene J. Dietrich, Zenan Li
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Patent number: 5990104Abstract: Polycyclic alkaloids of formula (I), wherein R.sub.1 is H, C.sub.1-6 alkyl, or C.sub.6-12 aryl optionally substituted with polar groups; R.sub.2 and R.sub.3 are independently H, OH, C.sub.1-6 alkyl, --C(NH)--NH.sub.2, a positively charged group, or C.sub.7-13 aralkyl optionally substituted with NH.sub.2, OH, C.sub.1-6 alkyl, or halogen; or R.sub.2 and R.sub.3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R.sub.4 is H, C.sub.1-6 alkyl, OR.sub.6, SR.sub.6, or N(R.sub.6).sub.2, wherein each R.sub.6 is independently H, C.sub.1-3 alkyl; X ix O, S, SO, SO.sub.2, or N--R.sub.5, wherein each R.sub.5 is independently H, C.sub.1-6 alkyl, or C.sub.7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; and m is an integer from 0 to 3. These compounds act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor.Type: GrantFiled: March 25, 1998Date of Patent: November 23, 1999Assignee: Biochem Pharma, Inc.Inventors: John Dimaio, Dilip M. Dixit
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Patent number: 5726208Abstract: New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers,and their addition salts with pharmaceutically acceptable acids.Those compounds may be used as medicaments.Type: GrantFiled: October 11, 1996Date of Patent: March 10, 1998Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Bertrand Goument, Jean-Christophe Harmange, Joel Vian, Aimee Dessinges, Mark Millan, Valerie Audinot
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Patent number: 5607624Abstract: A process for the preparation of compounds of formula I ##STR1## wherein the general symbols are as defined in claim 1, which comprises reacting a compound of formula III ##STR2## wherein the general symbols are as defined in claim 1, with a compound of formula IV[H].sub.n --R.sub.1 (IV).Type: GrantFiled: September 12, 1994Date of Patent: March 4, 1997Assignee: Ciba-Geigy CorporationInventors: Peter Nesvadba, Samuel Evans, Ralf Schmitt
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Patent number: 5463082Abstract: Stoichiometric and catalytic chemical transformations may be carried out in solution using novel fluorous multiphase systems (FMS). The term "fluorous" is defined as a carbon-fluorine bond rich organic molecule. The FMS consists of a fluorous phase containing a fluorous solvent, typically a fluorocarbon or a fluorohydrocarbon and a reagent or a catalyst containing a sufficient number of fluorous moieties to render it preferentially soluble in the fluorous solvent without impairing the ability of the catalyst or reagent to be effective in the reaction and while maintaining the reaction in a liquid or fluid phase. The nonfluorous solvent may be any suitable organic or nonorganic solvent(s) with limited or no solubility in the fluorous solvent that is effective for dissolving the reactant(s) and most desirably, for separating the resulting product(s). Typically, such solvents have a Hildebrand solubility parameter of at least about 18.0 MPa1/2.Type: GrantFiled: July 8, 1993Date of Patent: October 31, 1995Assignee: Exxon Research and Engineering CompanyInventors: Istvan T. Horvath, Jozsef Rabai
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Patent number: 5338821Abstract: Benzofuran-ether-sulphone monomers of formula ##STR1## and ether ketone polymers derived therefrom of formula ##STR2##Type: GrantFiled: April 26, 1993Date of Patent: August 16, 1994Assignee: Raychem LimitedInventor: Ian D. H. Towle
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Patent number: 5294522Abstract: A novel photochromic compound as a photoreactive material making use of photochromism is provided, which compound is expressed by the following formula (1) or (2)): ##STR1## wherein R is alkyl, alkoxy, perfluoroalkyl or cyano; X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and X.sub.6 are each H, halogen, alkyl, alkoxy, cyano, alkanoyloxy or alkyloxycarbonyl, or a substituted or unsubstituted benzene ring is formed by condensation between at adjacent groups among X.sub.1 to X.sub.6 ; Y is Y.sub.1 C=CY.sub.2, O, S, SO, SO.sub.2 or NY.sub.3 wherein Y.sub.1 and Y.sub.2 are each as defined in the case of the above X.sub.1 to X.sub.6 and Y.sub.3 is H, alkyl, alkanoyl, alkyloxycarbonyl or aryl; and the symbol refers to occurrence of E- or Z-isomer, and which compound is useful as rewritable optical memory element or photo-display element and also as solar energy-storage material, duplicating material, masking material, optical filter, toys, etc.Type: GrantFiled: March 2, 1993Date of Patent: March 15, 1994Assignee: Chisso CorporationInventors: Manabu Uchida, Masahiro Irie
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Patent number: 5208259Abstract: The invention concerns a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl;X.sup.1 is oxy, thio, sulphinyl or sulphonyl;Ar.sup.2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 is (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- wherein each of A.sup.2 and A.sup.3 is (1-4C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino.The invention also concerns processes for the manufacture of a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said heterocycle. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.Type: GrantFiled: July 3, 1990Date of Patent: May 4, 1993Assignees: Imperial Chemical Industries, ICI PharmaInventors: Thomas G. C. Bird, Philip N. Edwards
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Patent number: 4965284Abstract: This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.Type: GrantFiled: April 25, 1989Date of Patent: October 23, 1990Assignee: American Cyanamid CompanyInventors: Vijay G. Nair, Ramson B. Conrow, Bosco S. Wang, V. M. Ruszala-Mallon