Sulfur Or Halogen Attached Directly Or Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/511)
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Patent number: 6835746Abstract: Pharmaceutical compositions, methods of administration, and methods of treatment of cancer with new generation taxoids, of formulas (I) and (II), and derivatives thereof, are described:Type: GrantFiled: December 30, 2002Date of Patent: December 28, 2004Assignee: The Research Foundation of State University of New YorkInventor: Iwao Ojima
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Patent number: 6825365Abstract: The present invention relates to novel intermediates for the hemisynthesis of taxanes and to their processes of preparation. The compounds of the present invention include precursor compounds of taxane side chains.Type: GrantFiled: April 18, 2001Date of Patent: November 30, 2004Assignee: NovasepInventors: Luc Chanteloup, Bruno Chauveau, Christine Corbin, Robert Dhal, Sonia Le Guen, Arnaud Lamy, Antoine Leze, Jean-Pierre Robin
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Patent number: 6812356Abstract: 9-dihydro-13-acetylbaccatin III, one of the chemicals obtained from Taxus canadensis is used to produce, inter alia, 10-decetylbaccatin III, a useful intermediate for the preparation of paclitaxel and analogues thereof The 9-dihydro-13-acetylbaccatin III is converted into the 10-deacetylbaccatin III by a simple three step process involving (a) replacement of the C-7 hydroxyl group of tho 9-dihydro compound with a protecting group, (b) the oxidizing of the C-7 protected compound to produce a C-9 ketone, and (c) the deprotecting of the C-9 ketone to produce 10-deacetylbaccatin III.Type: GrantFiled: September 26, 2002Date of Patent: November 2, 2004Inventors: John Findlay, Ghislain Deslongchamps, Guoqiang Li
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Patent number: 6797833Abstract: Taxane derivatives having alternative C9 substituents.Type: GrantFiled: November 18, 2002Date of Patent: September 28, 2004Assignee: Florida State UniversityInventors: Robert A. Holton, Ki-byung Chai, Yukio Suzuki
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Patent number: 6794523Abstract: Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.Type: GrantFiled: September 17, 2002Date of Patent: September 21, 2004Assignee: Florida State UniversityInventors: Robert A. Holton, Ki-byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Kasthuri Rengan, Yukio Suzuki, Chunlin Tao
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Patent number: 6784304Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.Type: GrantFiled: December 11, 2001Date of Patent: August 31, 2004Assignee: Bristol-Myers Squibb CompanyInventors: John K. Thottathil, Ivan D. Trifunovich
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Patent number: 6780879Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 2, 2001Date of Patent: August 24, 2004Assignee: FSU Research Foundation, Inc.Inventor: Robert A. Holton
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Patent number: 6777563Abstract: The present invention provides a process for synthesizing 3-fluoroalkoxymethyl-3-alkyloxetanes, suitable as intermediates for preparing various fluorine-containing functional materials, represented by General Formula (Ia): wherein, X1 and X2 independently represent hydrogen or fluorine; Rf represents fluorine or C1-C18 linear or branched perfluoroalkyl; and R represents methyl, ethyl, n-propyl or isopropyl.Type: GrantFiled: November 17, 2003Date of Patent: August 17, 2004Assignee: Daikin Industries, Ltd.Inventor: Akinori Yamamoto
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Patent number: 6774249Abstract: Improved polymer-immobilized photosensitizer are disclosed as well as methods of preparing and using them. The polymer-immobilized photosensitizers comprise a cross-linked polymer backbone, a plurality of cationic ammonium or phosphonium groups covalently bound to the polymer backbone and an immobilized photosensitizer. The average total number of carbon atoms in the ammonium or phosphonium group is at least four and preferably at least 12. The photosensitizer can be either covalently or ionically bound to the polymer. Polymer-supported photosensitizers of the invention are unexpectedly superior in catalyzing the photosensitized oxidation of compounds containing carbon-carbon double bonds.Type: GrantFiled: September 27, 2001Date of Patent: August 10, 2004Assignee: Lumigen, Inc.Inventors: Hashem Akhavan-Tafti, Richard S. Handley, Mark D. Sandison, Randall K. Larkin
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Patent number: 6768012Abstract: A process for the preparation of paclitaxel starting from 10-deacetylbaccatine III.Type: GrantFiled: June 5, 2003Date of Patent: July 27, 2004Assignee: Indena S.p.A.Inventors: Arturo Battaglia, Paolo Dambruoso, Andrea Guerrini, Ezio Bombardelli, Alessandro Pontiroli
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Patent number: 6765015Abstract: This invention is directed to novel halogenated paclitaxel derivatives, processes for their preparation and use as effective anti-tumor agents.Type: GrantFiled: August 23, 2001Date of Patent: July 20, 2004Assignee: Xechem International, Inc.Inventors: Ramesh C. Pandey, Luben K. Yankov
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Patent number: 6762309Abstract: Taxane derivatives having alternative C7 substituents.Type: GrantFiled: September 20, 2002Date of Patent: July 13, 2004Assignee: Florida State UniversityInventors: Robert A. Holton, Ki-byung Chai
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Patent number: 6759539Abstract: Disclosed is a process for isolating and purifying paclitaxel from a natural resource of taxanes, comprising the steps of (a) washing a raw material comprising paclitaxel with water in order to remove soluble impurities from the raw material; (b) extracting with an organic solvent a wet raw material comprising paclitaxel; (c) contacting the wet raw material with a salt to obtain a biomass by precipitation, isolation, and drying; (d) removing resin and natural pigments from the dried biomass by dissolving the biomass in acetone or an acetone-hexane mixture, and adding at least one polar solvent until a paclitaxel-enriched oil phase is obtained; and (e) chromatography purifying the paclitaxel-enriched oil phase in a volatile solvent to obtain a purified solution, followed by crystallization.Type: GrantFiled: February 27, 2003Date of Patent: July 6, 2004Assignee: Chaichem Pharmaceuticals InternationalInventors: Trung Bui-Khac, Michel Potier
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Patent number: 6753434Abstract: These compounds contain an oxetane functionality and a cinnamyl functionality. The oxetane functionality is homopolymerizable in reactions that can undergo cationic or anionic ring opening, and the cinnamyl functionality is polymerizable with compounds such as electron acceptor compounds. The dual functionality allows for dual cure processing. The generic structure of such compounds is in which R is a methyl or ethyl group, X and Y independently are a direct bond, or an ether, ester, or carbamate group, and Q is a divalent hydrocarbon (which may contain heteroatoms of N, O, or S), provided that X and Y will not both be direct bonds in the same molecule.Type: GrantFiled: May 6, 2003Date of Patent: June 22, 2004Assignee: National Starch and Chemical Investment Holding CorporationInventor: Osama M. Musa
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Patent number: 6753345Abstract: An antitumor compound of formula (5): Also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2′ and 7 positions of paclitaxel is followed by the hydrolysis of the 2′ hexanoate group resulting in 7-hexanoyltaxol.Type: GrantFiled: July 19, 2002Date of Patent: June 22, 2004Assignee: Hauser, Inc.Inventors: Christopher K. Murray, Qun Y. Zheng, Sagar R. Shakya
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Patent number: 6750246Abstract: The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations. The invention claims compounds of formula I and the use of compounds of formula I or pharmaceutical salts thereof as oral drugs for the treatment of human or veterinary disease. in which: R is phenyl, isopropyl, or tert butyl; R1 is —C(O)Rz in which Rz is (CH3)3CO—, (CH3)3CCH2—, CH3(CH2)3O—, cyclobutyl-, cyclohexyloxy, or (2-furyl); R2 is CH3C(O)O—.Type: GrantFiled: November 14, 2000Date of Patent: June 15, 2004Assignee: Bristol-Myers Squibb CompanyInventors: John F. Kadow, Harold Mastalerz, Qiufen May Xue, Steven Hansel, Mary Edson Zoeckler, William C. Rose, James G. Tarrant
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Patent number: 6750245Abstract: Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 6, 2002Date of Patent: June 15, 2004Assignee: FSU Research Foundation, Inc.Inventor: Robert A. Holton
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Patent number: 6727369Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R7COO— and/or R8COO—, respectively, wherein R7 and R8 are independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C8 alkynyl, moncyclic aryl, or monocyclic heteroaryl.Type: GrantFiled: April 14, 1995Date of Patent: April 27, 2004Assignee: Florida State UniversityInventors: Robert A. Holton, Seokchan Kim, Yukio Suzuki
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Patent number: 6710191Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.Type: GrantFiled: July 30, 2002Date of Patent: March 23, 2004Assignee: Florida State UniversityInventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
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Patent number: 6706708Abstract: A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.Type: GrantFiled: July 31, 2002Date of Patent: March 16, 2004Assignee: Immunogen, Inc.Inventors: Ravi V. J. Chari, Walter A. BlƤttler
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Patent number: 6706896Abstract: Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.Type: GrantFiled: September 28, 2000Date of Patent: March 16, 2004Assignee: Florida State UniversityInventors: Robert A. Holton, Zhuming Zhang, Paul A. Clarke
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Patent number: 6683196Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a &bgr;-lactam.Type: GrantFiled: November 6, 2002Date of Patent: January 27, 2004Assignee: Florida State UniversityInventor: Robert A. Holton
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Patent number: 6683109Abstract: N-deacetyl-thiocolchicine and 10-deacetyl-baccatin III derivatives of formula (I) wherein R and n have the meanings specified in the disclosure, are valuable antitumoral drugs.Type: GrantFiled: August 2, 2002Date of Patent: January 27, 2004Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Alessandro Pontiroli
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Patent number: 6677456Abstract: This invention is to provide a novel taxol derivative useful as an antitumor compound having respective substituent groups, represented by the following formula (I) which can be orally administeredType: GrantFiled: March 6, 2002Date of Patent: January 13, 2004Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Tsunehiko Soga, Kouichi Uoto, Yasuyuki Takeda
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Patent number: 6673833Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 2, 2001Date of Patent: January 6, 2004Assignee: FSU Research Foundation, Inc.Inventor: Robert A. Holton
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Patent number: 6673947Abstract: The present invention provides a process for synthesizing 3-fluoroalkoxymethyl-3-alkyloxetanes suitable as intermediates for preparing various fluorine-containing functional materials, the process comprising using 3-alkyloxetane methanol as a starting compound and adding the compound to a fluoroolefin in the presence of an alkali.Type: GrantFiled: September 23, 2002Date of Patent: January 6, 2004Assignee: Daikin Industries, Inc.Inventor: Akinori Yamamoto
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Patent number: 6673948Abstract: A process for preparing compounds of formula (I) comprising radical addition of RfI to 3-(allyloxy)methyl-3-alkyloxetane (1) wherein R is C1-3 alkyl and Rf is C1-18 linear or branched fluoroalkyl. The compounds of formula (I) are useful as intermediates for preparing various fluorine-containing functional materials.Type: GrantFiled: September 23, 2002Date of Patent: January 6, 2004Assignee: Daikin Industries, Ltd.Inventors: Tetsuya Masutani, Akinori Yamamoto
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Patent number: 6664275Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 2, 2001Date of Patent: December 16, 2003Assignee: FSU Research Foundation, Inc.Inventor: Robert A. Holton
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Patent number: 6660866Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 2, 2001Date of Patent: December 9, 2003Assignee: PSU Research Foundation, Inc.Inventor: Robert A. Holton
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Patent number: 6660344Abstract: New photopolymerizable liquid crystalline dioxetane compounds are provided having the general formula I: wherein R1 and R2 are independently selected from straight or branched C1-C4 alkyl and hydrogen; X and X′ are independently selected from oxygen, sulfur, a single covalent bond, —O—CO—, —CO—O—, and —O—CO—O—; Y and Y′ are spacer groups having each independently 1 to 30 carbon atoms (linear or branched), in which the carbon chain may be interrupted by oxygen in the ether function or by sulfur in the thioether function; Z and Z′ are independently selected from oxygen, sulfur, a single covalent bond, —O—CO—, —CO—O—, and —O—CO—O—; and M is any suitable mesogenic group. Also, compositions are provided containing one or more compounds of formula I, as well as methods of preparing said compounds and compositions.Type: GrantFiled: October 3, 2001Date of Patent: December 9, 2003Assignee: Koninklijke Philips Electronics N.V.Inventor: Johan Lub
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Patent number: 6656966Abstract: The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix.Type: GrantFiled: June 22, 2001Date of Patent: December 2, 2003Assignee: NitroMed, Inc.Inventors: David S. Garvey, L. Gordon Letts, Chia-En Lin, Stewart K. Richardson, Tiansheng Wang
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Patent number: 6653490Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a &bgr;-lactam.Type: GrantFiled: July 12, 2002Date of Patent: November 25, 2003Assignee: Florida State UniversityInventor: Robert A. Holton
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Patent number: 6649777Abstract: Taxane derivatives having alternative C2 substituents.Type: GrantFiled: December 12, 2001Date of Patent: November 18, 2003Assignee: Florida State UniversityInventors: Robert A. Holton, Chunlin Tao
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Patent number: 6649778Abstract: Methods of preparing amino acid-substituted taxanes such as: using selected blocked amino acids are disclosed. After coupling of the blocked amino acid to the taxane, deprotection is carried out with about an equimolar amount of a secondary amine thus substantially avoiding base-catalyzed hydrolysis of amino acid from the taxane. The preferred amino acid-taxanes are useful as intermediates in the production of polymer conjugated therapeutic compositions or as part of pharmaceutically acceptable formulations.Type: GrantFiled: September 20, 2002Date of Patent: November 18, 2003Assignee: Enzon, Inc.Inventors: Hong Zhao, Richard B. Greenwald
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Patent number: 6649632Abstract: Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 2, 2001Date of Patent: November 18, 2003Assignee: FSU Research Foundation, Inc.Inventor: Robert A. Holton
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Publication number: 20030208015Abstract: Monofunctional polyfluorooxetane oligomers, polymers, and copolymers are prepared by the cationic polymerization of fluorooxetane monomers with a monoalcohol. In addition to serving as an initiator, the monoalcohol can also serve as a solvent for the fluorooxetane or other monomers to produce oligomers, polymers, or copolymers having low cyclic content. Suitable comonomers generally include various cyclic ethers. The polyfluorooxetane oligomer, polymer, or copolymer having a single hydroxyl end group can be functionalized with a variety of compounds so as to yield a functional end group such as an acrylate, a methacrylate, an allylic, an amine, etc., with the functionalized oligomer or polymer being suitable for use in radiation curable or thermal curable coating compositions. These functionalized polymers can be copolymerized and cured to provide improvements in wetting and surface properties.Type: ApplicationFiled: December 1, 2000Publication date: November 6, 2003Inventors: Robert Medsker, Gary L. Jialanella, Raymond J. Weinert, Guillermina C. Garcia, Aslam Malik, Roland Carlson
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Patent number: 6638742Abstract: Methods for obtaining taxanes from novel sources are disclosed. Angiosperms other than hazelnut and the gymnosperm ginkgo have been discovered to be sources of taxane, including paclitaxel. Taxane may also be obtained from fungal endophytes from these plants. Methods for optimizing the recovery of taxane from plant sources are disclosed in which a plant part is surface-sterilized before extracting taxane therefrom or before culturing fungal endophytes therefrom.Type: GrantFiled: July 6, 2001Date of Patent: October 28, 2003Assignee: University of PortlandInventor: Angela Hoffman
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Patent number: 6624317Abstract: Compounds according to formula I: T1—L—T2 (I), wherein T1 is a taxoid group, preferably of Formula II: wherein R1 is C6H5; R2 is O; L is a linking group; and T2 is a substituent selected from the group consisting of epipodophyllotoxin, amsacrine, ellipticine, anthracycline antibiotic, mitoxantrone, and colchicine groups, and pharmaceutically acceptable salts thereof, are provided herein. The compounds are useful in, among other things, treating tumors or cancer in subjects in need thereof, inducing cellular differentiation, and inhibiting cellular mitosis.Type: GrantFiled: September 25, 2000Date of Patent: September 23, 2003Assignee: The University of North Carolina at Chapel HillInventors: Kuo-Hsiung Lee, Qian Shi, Kenneth F. Bastow, Hui-Kang Wang
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Patent number: 6610860Abstract: Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 2, 2001Date of Patent: August 26, 2003Assignee: FSU Research Foundation, Inc.Inventor: Robert A. Holton
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Patent number: 6596737Abstract: Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.Type: GrantFiled: February 2, 2001Date of Patent: July 22, 2003Assignee: FSU Research Foundation, Inc.Inventors: Robert A. Holton, Weishuo Fang
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Patent number: 6596757Abstract: A cytotoxic agent comprising one or more polyethylene glycol-containing taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more polyethylene glycol-containing taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more polyethylene glycol-containing taxanes linked to a cell binding agent.Type: GrantFiled: May 14, 2002Date of Patent: July 22, 2003Assignee: Immunogen Inc.Inventors: Ravi V. J. Chari, Michael Louis Miller
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Patent number: 6596880Abstract: This invention relates to a method for preparing taxane derivatives of general formula (I) by esterification at a temperature between −10 and 60° C. of a derivative of baccatine III or 10-deacetyl baccatine III of general formula (II) by means of an acid of general formula (III), followed by replacement of the protective groupings G1, G2 and R2 of the resulting product by hydrogen atoms. In formulae (I), (II) or (III), Ar stands for an aryl radical; R stands for hydrogen or acetyl; R1 is benzoyl or ter.butoxycarbonyl; G1 is a hydroxy function protective grouping, G2 stands for the acetyl radical or a hydroxy function protective grouping, and R2 stands for a hydroxy function protective grouping.Type: GrantFiled: August 2, 1994Date of Patent: July 22, 2003Assignee: Aventis Pharma S.A.Inventors: Elie Fouque, Jean-Manuel Mas
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Patent number: 6589979Abstract: Seco-baccatin III derivatives of formula: wherein R, R1-R4, R1, R11, and R111 are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; and methods for treating cancer, arthritis, and inhibiting angiogenesis in an animal comprising administering to a patient in need thereof a therapeutically effective amount of a seco-baccatin III derivative are disclosed.Type: GrantFiled: July 3, 2002Date of Patent: July 8, 2003Assignee: Indena SpAInventors: Ezio Bombardelli, Alessandro Pontiroli
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Patent number: 6589765Abstract: The present invention relate to a method to increase the production level of paclitaxel by changing the temperature during the plant cell culture. According to the present invention, the production of the paclitaxel comprises the following procedure: (i) cultivating the Taxus genus plant cells in a medium at ca. 20 to 25° C.; and (ii) when growth of the plant cells has progressed sufficiently, changing the cultivation temperature to ca. 26 to 32° C. to continue the culture. The present invention comprises also the method of increasing the paclitaxel production by inoculating the cells at a high initial concentration and by increasing the saccharide concentration in the medium: According to the present invention, paclitaxel can be mass-produced conveniently and therefore has an industrial application.Type: GrantFiled: February 26, 1999Date of Patent: July 8, 2003Assignee: Samyang Genex CorporationInventors: Ho-Joon Choi, Hyung-Kyoon Choi, Sang-Ic Kim, Jeong-Hwan Yun, Joo-Sun Son, Moon-Seok Chang, Eunsoo Choi, Hong-Rak Kim, Seung-Suh Hong, Hyun-Soo Lee
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Patent number: 6576777Abstract: The present invention relates to a semi-synthetic process to convert a naturally occurring taxane into a suitable starting material for the synthesis of paclitaxel and related compounds. Specifically, the present invention relates to a process for the conversion of 9-dihydro-13-acetylbaccatin III into a 7-protected baccatin III which can then be used as starting material for the synthesis of taxane derivatives such as paclitaxel, docetaxel, cephalomannine and other taxanes structurally related to baccatin III. The method as described uses a preparative scale technique which is amenable to commercial scale-up.Type: GrantFiled: December 22, 2000Date of Patent: June 10, 2003Assignee: Institut National de la Recherche ScientifiqueInventors: Lolita Zamir, GaƩtan Caron
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Patent number: 6552205Abstract: Taxane derivatives having alternative C10 substituents.Type: GrantFiled: October 27, 1999Date of Patent: April 22, 2003Assignee: Florida State UniversityInventors: Robert A. Holton, Ki-byung Chai
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1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
Patent number: 6545168Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.Type: GrantFiled: May 5, 1997Date of Patent: April 8, 2003Assignee: Florida State UniversityInventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza -
Patent number: 6541508Abstract: Taxane prodrugs comprise a taxane joined by a hydrolyzable bond to one or more oligomers that comprise a polyethylene glycol moiety. The oligomer preferably further comprises a salt-forming moiety.Type: GrantFiled: March 9, 2001Date of Patent: April 1, 2003Assignee: Nobex CorporationInventors: Nnochiri N. Ekwuribe, Christopher H. Price, Gary S. Bartley
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Patent number: 6531611Abstract: The present invention provides a novel semi-synthetic method of producing a variety of novel taxane derivatives. The method involves the reaction of a phenylisoserine derivative with a suitably blocked Baccatin III derivative to produce a taxane substrate that may be further modified to form Pactitaxel and other potentially useful taxane derivatives.Type: GrantFiled: March 23, 2001Date of Patent: March 11, 2003Assignee: Scinopharm Taiwan, Ltd.Inventors: George Schloemer, Yung-Fa Chen, Chien Hsin Lin, Wlodzimierz Daniewski
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Patent number: 6521660Abstract: Taxane derivatives having an alkyl substituted C13 side chain.Type: GrantFiled: April 29, 2002Date of Patent: February 18, 2003Assignee: Florida State UniversityInventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Yukio Suzuki