Ring Oxygen In The Additional Hetero Ring Patents (Class 549/60)
  • Preparing amidines derived from 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
    Patent number: 6653472
    Abstract: New intermediates of the formula (II)B described below for the synthesis of amidine derivatives of (−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, such as for example (S)-N-{4-[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)-carbonyl]-1-piperazinyl]phenyl}-2-thiophenecarboximidamide wherein A′ is X is —Z1—CO; &rgr; is a bond or a heterocycle selected from the group consisting of piperidine, piperazine, homopiperazine, 2-methylpiperazine, 2,5-dimethyl-piperazine and 4-aminopiperidine; Y is —Z2— or —NR3—Z2, R3 is hydrogen, alkyl of 1 to 6 carbon atoms or —COR4, R4 is alkyl of 1 to 6 carbon atoms; Z1 and Z2 independently are a single bond or alkylene of 1 to 6 carbon atoms; and R6 is hydrogen or OH.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: November 25, 2003
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Christine Le Breton, Eric Manginot, Jean-Bernard Cazaux
  • C10 ester substituted taxanes
    Patent number: 6649632
    Abstract: Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: November 18, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Highly stable and efficient nonlinear optical chromophores for electro-optic polymers
    Publication number: 20030205701
    Abstract: In various embodiments, chromophores are described that include novel electron acceptors, novel electron donors, and/or novel conjugated bridges that are useful in nonlinear optical applications. In some embodiments, the present invention provides chromophore architectures wherein a chromophore contains more than one electron acceptor in electronic communication with a single electron donor, and/or more than one electron donor in electronic communication with a single electron acceptor. Also described is processes for providing materials comprising the novel chromophores and polymer matrices containing the novel chromophores. Electro-optic devices described herein contain one or more of the described electron acceptors, electron donors, conjugated bridges, or chromophores.
    Type: Application
    Filed: May 16, 2003
    Publication date: November 6, 2003
    Inventors: Diyun Huang, Tim Londergan, Galina K. Todorova, Jingsong Zhu
  • Low loss electro-optic polymers and devices made therefrom
    Publication number: 20030201429
    Abstract: The synthesis of novel, high &mgr;&bgr; electro-optical chromophores is described. These chromophores are polymerizable with a host polymer or copolymer. The chromophore polymerizable groups comprise epoxy, thioepoxy, oxetane and thiooxetane material which undergo a ring opening polymerization reaction in the presence of a cationic photoinitiator and actinic radiation. The high &mgr;&bgr; chromophores, mixed with a selected host polymer, copolymer, oligomer, or one or a plurality of polymerizable monomers, can be used to prepare optical waveguides and other optical elements and/or devices. The electro-optical chromophores of the invention can be used as a replacement for LiNbO3 in the formation of electro-optical devices, particularly electro-optical modulators.
    Type: Application
    Filed: April 30, 2002
    Publication date: October 30, 2003
    Inventors: Mingqian He, Paul J. Shustack, Jianguo Wang
  • Methods of making substituted phenylketoenols
    Patent number: 6630594
    Abstract: The present invention provides methods of making substituted phenylketoenols of the general formula I, wherein V, W, X, Y, Z and Het are as defined herein. The compounds have pesticidal and herbicidal activity.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: October 7, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hermann Hagemann, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Peter Dahmen, Markus Dollinger, Alan Graff, Wolfram Andersch
  • Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
    Patent number: 6627652
    Abstract: Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid receptor sites in preference to the RAR retinoid receptor sites. A compound is defined to be a selective agonist of the RXR receptor site if the compound is at least approximately ten times more effective as an agonist in the RXR receptor sites than in the RAR receptor sites.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: September 30, 2003
    Assignee: Allergan, Inc.
    Inventor: Roshantha A. S. Chandraratna
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Publication number: 20030176491
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 18, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Leo M. Albert
  • GLYT-1 INHIBITORS
    Publication number: 20030176489
    Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: 1
    Type: Application
    Filed: February 15, 2002
    Publication date: September 18, 2003
    Inventors: Zhaoqing Wang, William Delaney, Ashok Tehim, Shawn Maddaford, Ian Egle, Richard Schumacher, Allen T. Hopper
  • Process for the preparation of thiazolidinedione derivatives
    Patent number: 6620941
    Abstract: The present invention is concerned with a novel process for the preparation of compounds of formula I comprising bromomethylation or chloromethylation of a compound of formula II and subsequent reaction with a compound of formula IV The compounds of formula I and the corresponding salts, e.g. the sodium salts, are pharmaceutically active substances.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: September 16, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Michelangelo Scalone
  • Selenophene anti-tumor agents
    Patent number: 6620804
    Abstract: Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: wherein R1 and R2 are independently selected from the group consisting of; H, CHO, CH2OH and CH2NH2; and X and Y are independently selected from the group consisting of Se, S, O, NCH3 and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: September 16, 2003
    Assignee: Purdue Research Foundation
    Inventors: Ching-jer Chang, Curtis L. Ashendel, Darrick Kim
  • Thienylsulphonylamino(thio)carbonyl compounds
    Publication number: 20030171595
    Abstract: The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), 1
    Type: Application
    Filed: October 31, 2002
    Publication date: September 11, 2003
    Inventors: Klaus-Helmut Muller, Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Rolf Kirsten, Joachim Kluth, Klaus Konig
  • C7 ester substituted taxanes
    Patent number: 6610860
    Abstract: Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: August 26, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Heterocyclic sulfonamide inhibitors of beta amyloid production
    Patent number: 6610734
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 26, 2003
    Assignees: Wyeth, ArQule Inc.
    Inventors: Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier, Lynn Resnick
  • Non-psychotropic cannabinoids
    Patent number: 6610737
    Abstract: Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of &Dgr;6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain inflammatory disorders and chronic degenerative diseases characterized by neuronal loss and chronic pain including neuropathic pain.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: August 26, 2003
    Assignee: Pharmos Corporation
    Inventors: Aaron Garzon, George Fink
  • Certain substituted polyketides, pharmac eutical compositions containing them and their use in treating tumors
    Publication number: 20030153601
    Abstract: The present invention relates to certain substituted polyketides of formula I, 1
    Type: Application
    Filed: November 12, 2002
    Publication date: August 14, 2003
    Inventors: Frederick R. Kinder, Kenneth W. Bair, Timothy M. Ramsey, Michael L. Sabio
  • C10 carbamoyloxy substituted taxanes
    Patent number: 6596737
    Abstract: Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: July 22, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Weishuo Fang
  • Glucocorticoid receptor antagonists for treatment of diabetes
    Patent number: 6593480
    Abstract: Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: July 15, 2003
    Assignee: Abbott Laboratories
    Inventors: Philip R. Kym, Benjamin C. Lane, John K. Pratt, Tom Von Geldern, Martin Winn, Jehrod Brenneman, Jyoti R. Patel, David L. Arendsen, Irini Akritopoulou-Zanze, Kimba L. Ashworth, Kresna Hartandi
  • Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
    Publication number: 20030130279
    Abstract: The present invention relates to compounds with the formula (I) 1
    Type: Application
    Filed: November 22, 2002
    Publication date: July 10, 2003
    Inventors: Guido Kurz, Marianne Nilsson, Jerk Vallgarda, Meredith Williams
  • Red-emitting organic electroluminescent compound
    Publication number: 20030127975
    Abstract: A red-emitting organic electroluminescent compound, the structure of the compound as follows: 1
    Type: Application
    Filed: December 5, 2002
    Publication date: July 10, 2003
    Applicant: CHI MEI OPTOELECTRONICS CORPORATION
    Inventors: Ruey-Min Chen, Jun-Wen Chung, Chun-Che Hsu
  • Aryl or heteroaryl substituted 3,4-dihydroanthracene and aryl or heteroaryl substituted benzo[1,2-g]-chrom-3-ene, benzo[1,2-g]-thiochrom-3-ene and benzo [1,2-g]-1,2-dihydroquinoline derivatives having retinoid antagonist or retinoid inverse agonist type biological activity
    Publication number: 20030130515
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: January 2, 2003
    Publication date: July 10, 2003
    Inventors: Vidyasagar Vuligonda, Alan T. Johnson, Roshantha A. Chandraratna
  • C10 carbonate substituted taxanes
    Publication number: 20030114493
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 2, 2001
    Publication date: June 19, 2003
    Inventor: Robert A. Holton
  • Sulfonylaminocarboxylic acids
    Publication number: 20030087945
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: June 13, 2002
    Publication date: May 8, 2003
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Werner Thorwart, Wilfried Schwab, Manfred Schudok, Burkhard Haase
  • Polymeric matrix compatibilized naphthopyrans
    Patent number: 6555028
    Abstract: Described are polymeric matrix compatibilized naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one substituent containing terminal and/or pendant groups selected from hydroxyl, carboxyl, sulfo, sulfono, (meth)acryloxy, 2-(methacryloxy)ethylcarbamyl, epoxy or a mixture thereof. Specific substituents are also present on the naphtho, indeno and/or pyrano portions of the compounds. These compounds may be represented by the following graphic formulae: Also described are various substrates that contain or that are coated with such compounds. Optically clear articles such as contact lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, are also described.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: April 29, 2003
    Assignee: Transitions Optical, Inc.
    Inventors: Robert W. Walters, Barry Van Gemert
  • Photochromic bis-naphthopyran compounds and methods for their manufacture
    Publication number: 20030078441
    Abstract: The invention provides photochromic bis-naphthopyran compounds as well as methods for their manufacture and their use. The bis-naphthopyran compounds of the invention exhibit a wide range of color, i.e., from pink to purple to blue gray, upon activation by a source of UV light. Additionally, the bis-naphthopyran compounds of the present invention exhibit broad coloration ability, fast response as to both color change on activation and return to original color, and good fatigue-resistance.
    Type: Application
    Filed: September 4, 2001
    Publication date: April 24, 2003
    Inventors: Weili Zhao, Erick M. Carreira
  • C10 OXO and hydrido taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6552205
    Abstract: Taxane derivatives having alternative C10 substituents.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: April 22, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • C7 carbamate substituted taxanes
    Publication number: 20030060638
    Abstract: Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 6, 2002
    Publication date: March 27, 2003
    Applicant: Florida State University Research Foundation Inc.
    Inventor: Robert A. Holton
  • P-thienylbenzylamides as agonists of angiotensin-(1-7) receptors, and methods of their preparation and use
    Patent number: 6538144
    Abstract: The invention relates to p-thienylbenzylamides of formula (I) in which R(1), R(2), R(3), R(4), R(5), R(6) and X have the meanings given in the description. The compounds of formula (I) are potent agonists of angiotensin-(1-7) receptors and are useful as pharmaceutically active compounds to treat and/or prevent hypertension; cardiac hypertrophy; cardiac insufficiency; coronary heart diseases, such as angina pectoris; and endothelial dysfunction or endothelial damage as a consequence, for example, of atherosclerotic processes or in association with diabetes mellitus.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: March 25, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventor: Holger Heitsch
  • Pharmaceutical compounds and methods of use thereof
    Publication number: 20030055084
    Abstract: The present invention provides substituted benzofuran, indene, thianaphthene and oxidized thianaphthene compounds and methods of treatment and pharmaceutical compositions that comprise such compounds. Preferred compounds of the invention contain benzofuran, indene or thianaphthene group substituted with a tetrahydrofuran or other alicyclic group.
    Type: Application
    Filed: July 30, 2002
    Publication date: March 20, 2003
    Applicant: Millennium Pharmaceutical, Inc.
    Inventors: Gurmit Grewal, Ralph Scannell, Xiong Cai, Michelle Young, Aberra Fura
  • Bridged aromatic substituted amine ligands with donor atoms
    Patent number: 6528627
    Abstract: The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 4, 2003
    Assignee: NeoRx Corporation
    Inventor: Sudhakar Kasina
  • Bromonitrothienyldioxanes
    Publication number: 20030040540
    Abstract: The invention relates to novel 5-bromo-5-nitro-2-thienyl-1,3-dioxanes of the formula (I) 1
    Type: Application
    Filed: July 3, 2002
    Publication date: February 27, 2003
    Inventors: Hermann Uhr, Karl-Heinz Kuck, Martin Kugler, Peter Wachtler
  • 3?-alkyl substituted taxanes and pharmaceutical compositions containing them
    Patent number: 6521660
    Abstract: Taxane derivatives having an alkyl substituted C13 side chain.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: February 18, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Yukio Suzuki
  • Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
    Patent number: 6521622
    Abstract: Heterocyclic aromatic amides having a hydroxy group adjacent to the amide functionality are useful as antifungal agents, particularly for plants.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: February 18, 2003
    Assignee: Dow AgroSciences LLC
    Inventors: Michael J. Ricks, William H. Dent, III, Richard B. Rogers, Chenglin Yao, Bassam S. Nader, John L. Miesel, Gina M. Fitzpatrick, Kevin G. Meyer, Noormohamed M. Niyaz, Irene M. Morrison, Robert P. Gajewski
  • 3,4-diaryl thiophenes and analogs thereof having use as anti-inflammatory agents
    Publication number: 20030013744
    Abstract: A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders.
    Type: Application
    Filed: July 1, 2002
    Publication date: January 16, 2003
    Applicant: G.D. Searle & Co.
    Inventors: John J. Talley, Stephen R. Bertenshaw, Paul W. Collins, Thomas D. Penning, David B. Reitz, Roland S. Rogers
  • Thienylsulphonylamino(thio)carbonyl compounds
    Publication number: 20030004354
    Abstract: The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), 1
    Type: Application
    Filed: November 9, 2001
    Publication date: January 2, 2003
    Inventors: Klaus-Helmut Muller, Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Rolf Kirsten, Joachim kluth, Klaus Konig, Ulrich Philipp, Markus Dollinger
  • Oxiran carboxylic acids for the treatment of diabetes
    Publication number: 20020198382
    Abstract: The invention relates to novel arylalkyl- or aryloxyalkyl-substituted oxiranecarboxyclic acids of the general formula I 1
    Type: Application
    Filed: June 18, 2002
    Publication date: December 26, 2002
    Inventor: Horst P.O. Wolf
  • 4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors
    Patent number: 6492416
    Abstract: The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: December 10, 2002
    Assignee: Pacific Corporation
    Inventors: Song Seok Shin, Min-Soo Noh, Young Joo Byun, Jin Kyu Choi, Jin Kwan Kim, Kyung Min Lim, Ji Young Kim, Young Hoon Choi, Jun-Yong Ha, Ki-Wha Lee, Joo Hyun Moh, Yeon Su Jeong, Shin Chung, Yung Hyup Joo, Chang Hoon Lee, Seon Hwa Kang, Young-Ho Park, Jung Bum Yi
  • NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS
    Publication number: 20020173667
    Abstract: Described are photochromic 2H-naphtho[1,2-] pyrans characterized by having an aromatic substituent in the 5 position. The aromatic group at 5-position of the naphthopyran is a substituted or unsubstituted aryl group or other substituted or unsubstituted aromatic group.
    Type: Application
    Filed: December 15, 2000
    Publication date: November 21, 2002
    Inventor: Jibing Lin
  • Photochromic pyran compounds
    Publication number: 20020169315
    Abstract: Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from naphthopyrans, which are known as spirofluorenopyrans. By introducing respectively only one strongly electron donating or withdrawing group at specific positions in the periphery of the pyran dye, photochromic compounds obtained which in the excited state are distinguished by an expanded color spectrum, while simulataneously offering comparably good bleaching rates and good durability.
    Type: Application
    Filed: February 7, 2002
    Publication date: November 14, 2002
    Inventors: Claudia Mann, Udo Weigand, Manfred Melzig
  • Aromatic substituted naphthopyrans
    Patent number: 6478989
    Abstract: Described are photochromic 2H-naphtho[1,2-b]pyrans characterized by having an aromatic substituent in the 5 position. The aromatic group at 5-position of the naphthopyran is a substituted or unsubstituted aryl group or other substituted or unsubstituted aromatic group. These compounds may be represented by the following graphic formula: Also described are polymeric organic host materials that contain or that are coated with such compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: November 12, 2002
    Assignee: Transitions Optical, Inc.
    Inventor: Jibing Lin
  • Chromene compounds
    Patent number: 6469076
    Abstract: A photochromic compound which by itself develops a color tone of a neutral tint, exhibits a large fading rate and offers a good photochromic light resistance.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: October 22, 2002
    Assignee: Tokuyama Corporation
    Inventors: Junji Momoda, Yasuko Komuro
  • O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
    Patent number: 6465663
    Abstract: Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: October 15, 2002
    Assignee: Allergan, Inc.
    Inventors: Vidyasagar Vuligonda, Min Teng, Richard L. Beard, Alan T. Johnson, Yuan Lin, Roshantha A. Chandraratna
  • Substituted &agr;, &bgr;-anellated butyrolactones
    Patent number: 6462074
    Abstract: The present invention relates to novel substituted (&agr;,&bgr;-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: October 8, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Andreas Stolle, Horst-Peter Antonicek, Stephen Lensky, Arnd Voerste, Thomas Müller, Jörg Baumgarten, Karsten von dem Bruch, Gerhard Müller, Udo Stropp, Ervin Horváth, Jean-Marie-Viktor de Vry, Rudy Schreiber
  • C7 acyloxy and hydrido taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6462208
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: October 8, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai
  • Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer
    Publication number: 20020137947
    Abstract: A novel compound which inhibits certain integrins, particularly &agr;v integrins. Additionally, the novel compound may be used in a method of treating tumors or cancer which comprises administering a pharmaceutically effective amount of the compound to a patient. Additionally, the novel compound may be used in a method of inhibiting angiogensis. Finally, a method of producing the novel compound is disclosed.
    Type: Application
    Filed: January 16, 2002
    Publication date: September 26, 2002
    Applicant: BioChem Pharma Inc.
    Inventors: Denis Labrecque, Serge Lamothe, Marc Courchesne, Laval Chan, Giorgio Attardo, Karen Meerovitch
  • 3-phenyl-pyrones
    Patent number: 6441030
    Abstract: Novel 3-phenyl-pyrones of the formula in which A, D, X and Y are each as defined in the description, a process for preparing these substances and their use as pesticides, fungicides and herbicides.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: August 27, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Michael Ruther, Christoph Erdelen, Wolfram Andersch, Ulrike Wachendorff-Neumann, Gerd Hänssler, Astrid Mauler-Machnik, Klaus Stenzel
  • Heterarylbenzene compounds
    Publication number: 20020115870
    Abstract: A method of preparing a compound of formula I is described.
    Type: Application
    Filed: November 21, 2001
    Publication date: August 22, 2002
    Inventors: Jiann T?apos;suen Lin, Iuan-Yuan Wu, Yu-Tai Tao, E. Balasubramaniam
  • Anti-inflammatory compounds
    Publication number: 20020103217
    Abstract: This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure: 1
    Type: Application
    Filed: January 8, 2002
    Publication date: August 1, 2002
    Inventors: Malcolm K. Scott, Pauline J. Sanfilippo, Louis J. Fitzpatrick, Richard Cordova, Kevin Pan, Joseph Meschino
  • Cyclopentabenzofuran derivatives and their use
    Patent number: 6420393
    Abstract: The invention relates to cyclopentabenzofuran derivatives, processes for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-&kgr;B-dependent diseases and medicaments which contain the cyclopentabenzofuran derivatives.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: July 16, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Guarnieri, Thomas Jaetsch, Andreas Schoop, Jörg Baumgarten, Axel Kretschmer, Horst-Peter Antonicek
  • Process for the preparation of 3-aryl-benzofuranones
    Patent number: 6417358
    Abstract: Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim 1, with carbon monoxide in the presence of a catalyst.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: July 9, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Michael Tinkl, Samuel Evans, Peter Nesvadba
  • Anilide derivative, production and use thereof
    Patent number: 6413947
    Abstract: This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an, optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: July 2, 2002
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Mitsuru Shiraishi, Takahito Kitayoshi, Yoshio Aramaki, Susumu Honda, Tsuneo Oda