The Hetero Ring Is Five-membered Patents (Class 549/6)
-
Patent number: 4826829Abstract: Thiophene derivatives of the following formula are effective as acaricdies: ##STR1## wherein A is selected from -phenylthienyl and -phenyl optionally carrying one or more substitutents selected from -lower alkyl, -lower alkoxy, -phenoxy, -hydroxy, -halogen, -lower haloalkyl, -phenylcarbonyl, -lower alkyl carbonyloxy, -lower alkyl sulfonyl, -lower alkyl sulfonyloxy, -amino, -lowr alkyl carboxamido, and -lower haloalkyl carboxamido;R.sub.4 is selected from -hydrogen and -lower alkyl; andR.sub.5 is selected from -thienyl optionally carrying one or more substituents selected from -lower alkyl, -phenylethynyl, -lower alkylthio, -lower haloalkyl carbonyl, and lower alkyl sulfoxy; or -phenyl optionally carrying one or more substituents selected from -lower alkyl and -lower alkoxy.Type: GrantFiled: March 9, 1988Date of Patent: May 2, 1989Assignee: FMC CorporationInventors: Susan E. Eurkart, Richard B. Phillips, David M. Roush
-
Patent number: 4806604Abstract: The present invention discloses a new class of calcium chelating compounds which have a decreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca.sup.2+ chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. However unlike EGTA or BAPTA-like compounds, in which the two halves of the chelator are linked by a simple 1,2-ethanediyl moiety, the compounds of the present invention modify the stereochemical conformation of this linkage by adding bulky substituents or incorporating the linkage into a carbocyclic or heterocyclic ring. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone.Type: GrantFiled: May 13, 1987Date of Patent: February 21, 1989Assignee: Regents of the University of CaliforniaInventors: Roger Yonchien Tsien, Stephen R. Adams
-
Patent number: 4806448Abstract: Compounds of formula I ##STR1## in conjunction with compounds that donate acid when exposed to actinic radiation, are suitable for use as positive photoresists. In formula I, R.sup.1 and R.sup.2 are hydrogen, alkyl, aryl, cycloalkyl, aralkyl or alkaryl, R.sup.3 to R.sup.8 are hydrogen or lower alkyl, X is --O-- or --NR.sup.9 --, where R.sup.9 is hydrogen or C.sub.1 -C.sub.4 alkyl n is 0 or 1, m is 2, 3 or 4 and Q is an organic radical of valency m.The photoresists are suitable for making printing formes, printed circuits, integrated circuits or silver-free photographic films.Type: GrantFiled: November 27, 1987Date of Patent: February 21, 1989Assignee: Ciba-Geigy CorporationInventor: Martin Roth
-
Patent number: 4804654Abstract: Compounds of the formula ##STR1## wherein the symbols have assigned meanings, and their use as insecticides and/or miticides.Type: GrantFiled: March 4, 1987Date of Patent: February 14, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mohamed A. H. Fahmy
-
Patent number: 4782079Abstract: Thiophene derivatives of the following formula are effective as acaricides: ##STR1## wherein R.sub.A is selected from -hydrogen, -halogen, -lower alkyl, hydroxy, -lower alkoxy, -lower alkylthio, -lower alkoxyalkoxy, -lower alkoxycarbonyl, -aryloxycarbonyl, -lower alkoxycarbonyloxy, -lower alkylsulfonyl, -lower alkylsulfonyloxy, -arylsulfonyloxy, and -lower alkyl phosphonyloxy;R.sub.B is -hydrogen, or R.sub.A and R.sub.B together are --C.sub.4 H.sub.4 --bridging 2'-3' or 3'-4';R.sub.3 and R.sub.4 are selected from -hydrogen, -lower alkyl, and -aryl;X is -halogen; andY is selected from -hydrogen and -halogen.Type: GrantFiled: January 26, 1988Date of Patent: November 1, 1988Assignee: FMC CorporationInventors: Susan E. Burkart, Richard B. Phillips, David M. Roush
-
Patent number: 4755611Abstract: Heterocyclic phosphine compounds, pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which comprises adminstering a tumor cell growth-inhibiting amount of such a compound to an animal afflicted by said tumor cells.Type: GrantFiled: August 11, 1987Date of Patent: July 5, 1988Assignee: SmithKline Beckman CorporationInventor: David T. Hill
-
Patent number: 4743618Abstract: Novel compounds useful as dopamine receptor agonists for the treatment of various diseases of the central nervous system such as Parkinson's disease and related disorders having the structural formula ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H, and OA; A is selected from the group consisting of hydrocarbyl radicals; ##STR2## where X is S or O: and pharmaceutically acceptable salts thereof. Also disclosed is a method for inducing a dopaminergic response in a patient by adminstering a pharmacologically-effective amount of one of the foregoing compounds.Type: GrantFiled: July 28, 1986Date of Patent: May 10, 1988Assignee: Nelson Research & Development Co.Inventor: Alan S. Horn
-
Patent number: 4722933Abstract: The invention provides compounds represented by the general formula ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H, and OA; A is H or ##STR2## R.sub.5 is selected from the group consisting of alkyl and aromatic residues; n is 2 or 3; and R.sub.1 is selected from the group consisting ##STR3## wherein R.sub.6 is selected from the group consisting of halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl, comprising from 1 to 12 carbon atoms and wherein said hetero-atoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus; R.sub.7 is R.sub.6 or H and m equals 1, 2 or 3; with the proviso that at least one of R.sub.2, R.sub.3 and R.sub.4 is H, that at least one of R.sub.2, R.sub.3 and R.sub.4 is not H and that R.sub.2 and R.sub.4 are not both OA; and pharmaceutically-acceptable salts thereof. The compounds are dopamine receptor agonists and useful for the treatment of glaucoma in mammals.Type: GrantFiled: March 17, 1986Date of Patent: February 2, 1988Assignee: Nelson Research & Development Co.Inventor: Alan S. Horn
-
Patent number: 4719203Abstract: Diphosphonate compounds, processes for their preparation and pharmaceutical compositions containing them and being useful for treating calcium metabolism disorders. The diphosphonates are of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, acyl or alkyl which can be substituted by aryl, R.sub.3 and R.sub.4 are hydrogen or alkyl or R.sub.3 and R.sub.4 together represent lower alkylene, R.sub.5 is a hydrogen atom or alkyl, X is a valency bond or alkylene, Y is a valency bond, alkylene or substituted alkylene, Z is hydrogen, hydroxyl or amino group optionally substituted by alkyl and n is 1, 2 or 3; and including the pharmacologically acceptable salts thereof.Type: GrantFiled: November 12, 1986Date of Patent: January 12, 1988Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall
-
Patent number: 4716230Abstract: Heterocyclic phosphine compounds, pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which comprises administering a tumor cell growth-inhibiting amount of such a compound to an animal afflicted by said tumor cells.Type: GrantFiled: March 25, 1986Date of Patent: December 29, 1987Assignee: Smithkline Beckman CorporationInventor: David T. Hill
-
Patent number: 4686298Abstract: Compounds of the formula ##STR1## are useful in the preparation of .alpha.-acyloxy phosphonate compounds. The final products are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: February 4, 1987Date of Patent: August 11, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Tamara Dejneka
-
Patent number: 4670422Abstract: Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.Type: GrantFiled: March 27, 1986Date of Patent: June 2, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Tamara Dejneka
-
Patent number: 4668823Abstract: A process for the selective production of bulky alkyldiarylphosphines and unsymmetrical dialkylarylphosphines comprising reacting a first Grignard reagent having a bulky alkyl group with an aryldichlorophosphine and thereafter and without isolating the resulting bulky alkylarylchlorophosphine intermediate, reacting said intermediate with a second Grignard reagent having a different, less bullky alkyl group or an aryl group to provide the product phosphine.Type: GrantFiled: December 30, 1983Date of Patent: May 26, 1987Assignee: Union Carbide CorporationInventor: Rex E. Murray
-
Patent number: 4656293Abstract: Organic chlorophosphanes of the formula III ##STR1## in which R.sup.1 is chlorine or an aliphatic radical, preferably only chlorine, andR.sup.2 is an aromatic, heterocyclic or aliphatic radical,are prepared by reacting organic phosphorus oxychlorides of the formula I ##STR2## in which R.sup.1 is chlorine or an aliphatic radical, preferably only chlorine,R.sup.2 is an aromatic or heterocyclic radical in the event that R.sup.1 is chlorine and an aromatic, heterocyclic or aliphatic radical in the event that R.sup.1 is an aliphatic radical,with a trialkylphosphane of the formula II(R.sup.3).sub.3 P (II)in which R.sup.3 is an aliphatic radical, at temperatures between about 20.degree. and about 170.degree. C. Said organic chlorophosphanes III are mainly intermediates in various fields, such as pharmaceuticals, plant protection, dyestuffs and polymers.Type: GrantFiled: January 9, 1986Date of Patent: April 7, 1987Assignee: Hoechst AktiengesellschaftInventor: Hans-Jerg Kleiner
-
Patent number: 4632995Abstract: Organic chlorophosphanes of the formula II ##STR1## in which R.sup.1 =an aromatic or heterocyclic radical and R.sup.2 =an aliphatic radical or Cl are prepared by reacting organic phosphorus oxychlorides of the formula I ##STR2## in which R.sup.1 and R.sup.2 have the meaning mentioned above with triphenylphosphane (C.sub.6 H.sub.5).sub.3 P at an elevated temperature. The organic chlorophosphanes II are, in the main, intermediates in various specialized fields, such as the pharmaceuticals, plant protection, dyestuffs and polymers sectors.Type: GrantFiled: April 12, 1984Date of Patent: December 30, 1986Assignee: Hoechst AktiengesellschaftInventor: Hans-Jerg Kleiner
-
Patent number: 4624695Abstract: The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more o-diaminophosphinyl derivatives of oximes, and methods and composition for inhibiting the activity of urease through use of such compounds.Type: GrantFiled: December 20, 1983Date of Patent: November 25, 1986Assignee: Allied CorporationInventors: Michael D. Swerdloff, Milorad M. Rogic, Larry L. Hendrickson
-
Patent number: 4616005Abstract: Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.Type: GrantFiled: December 16, 1985Date of Patent: October 7, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
-
Patent number: 4598071Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.Type: GrantFiled: November 28, 1984Date of Patent: July 1, 1986Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
-
Patent number: 4588838Abstract: The invention is directed to the electrodeposition of a coating of a phosphorylated amide on a metal such as aluminum and the formation of a chemical bond between the metal and the coating, such amide being in the form of (a) an organic polymer consisting of a poly (phosphinohydrazide), a poly (phosphinoguanide) or a poly (phosphinoureide), including homopolymers and copolymers thereof, and their thio analogs or (b) a 2:1 molar adduct of a nitrogen=containing compound such as hydrazine, guanidine or urea or its thio analog, and an organic phosphite or phosphonate. In the method of electrolytically depositing such coating on the metal substrate, e.g., aluminum, the substrate is employed as the anode in a non-aqueous or aqueous electrolyte containing a phosphorylated amide of the type noted above, e.g.Type: GrantFiled: May 27, 1983Date of Patent: May 13, 1986Assignee: McDonnell Douglas CorporationInventor: Norman R. Byrd
-
Patent number: 4568671Abstract: Oxime N-alkyl-N-.alpha.-(alkylthio-phosphorothio)acyl carbamates represented the structure: ##STR1## wherein the R represents various imino radicals, Q is oxygen or sulfur and the numbered R groups represent various alkyl substituents, which exhibit superior insecticidal and miticidal activity.Type: GrantFiled: June 30, 1983Date of Patent: February 4, 1986Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
-
Patent number: 4567168Abstract: A cyanohydrin phosphate of the formula ##STR1## wherein R represents a hydrogen atom or an optionally substituted radical selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl and aryl, or an optionally substituted heterocyclic radical,R.sup.1 and R.sup.2 are identical or different and individually represent optionally substituted radicals selected from alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkylthio, alkenylthio, alkinylthio, arylthio, aralkylthio, alkylamino (monoalkylamino or dialkylamino), arylamino and aralkylamino, or together represent alkanediyl, alkanedioxy, aminoalkyloxy or alkanediamino, andX represents oxygen or sulphur,are obtained by the reaction of a phosphoric acid chloride of the general formula ##STR2## wherein X, R.sup.1 and R.sup.2 have the meaning given above, with an aldehyde of the general formulaR--CHO (III)wherein R has the meaning given above, in the presence of an approximately equimolar quantity of water-soluble cyanides.Type: GrantFiled: January 28, 1982Date of Patent: January 28, 1986Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Hans-Jochem Riebel, Ingeborg Hammann, Bernhard Homeyer, Wilhelm Stendel
-
Patent number: 4567169Abstract: New nitrosourea compounds that can be used as medicaments and correspond to the general formula I ##STR1## in which R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or phenyl,R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, thienyl, or phenyl which may carry substituents,R.sub.3 is hydrogen, C.sub.1 -C.sub.6 alkyl, or benzyl which may carry substituents, orR.sub.2 and R.sub.3 together represent --(CH.sub.2).sub.m --, m being 3 or 4.Pharmaceutical compositions; therapeutic administration especially for the treatment of tumours.Type: GrantFiled: November 2, 1983Date of Patent: January 28, 1986Assignee: ADIR, s.a.r.l.Inventors: Gilbert Lavielle, Claude Cudennec
-
Patent number: 4562185Abstract: The present invention relates to combating pests with five-membered nitrogen-containing heterocyclic compounds of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in the description. Many of the compounds are new.Type: GrantFiled: March 15, 1984Date of Patent: December 31, 1985Assignee: Bayer AktiengesellschaftInventors: Gerhard Jager, Rudolf Fauss, Kurt Findeisen, Benedikt Becker, Bernhard Homeyer
-
Patent number: 4555506Abstract: Phosphorus containing compounds of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid and A is ##STR2## These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.Type: GrantFiled: December 24, 1981Date of Patent: November 26, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
-
Patent number: 4539421Abstract: The title compounds correspond to the formula ##STR1## and are useful as stabilizers for organic polymers and lubricating oils to counteract the degradative effects of heat, light and air.Type: GrantFiled: October 11, 1983Date of Patent: September 3, 1985Assignee: Ciba-Geigy CorporationInventors: John D. Spivack, Stephen D. Pastor, Paul Odorisio
-
Patent number: 4522693Abstract: Acylphosphine sulfides of the formula ##STR1## where R.sup.1 is alkyl, cycloalkyl or an unsubstituted or substituted phenyl, naphthyl or heterocyclic radical; R.sup.2 has the meaning of R.sup.1 and can be identical to or different from R.sup.1, or is alkoxy, unsubstituted or substituted phenoxy or phenoxyalkyl, or R.sup.1 or R.sup.2 are linked together to form a ring, which may contain further alkyl substituents and fused-on benzene rings; R.sup.3 is alkyl, a cycloaliphatic radical, substituted phenyl, an unsubstituted or substituted naphthyl or heterocyclic radical or the group ##STR2## where X is unsubstituted or substituted phenylene or an aliphatic or cycloaliphatic divalent radical; and where one or more of R.sup.1, R.sup.2 and R.sup.3 may be olefinically unsaturated.These acylphosphine sulfides can be prepared from acylphosphines and sulfur and can be used as photoinitiators in photopolymerizable compositions.Type: GrantFiled: June 2, 1983Date of Patent: June 11, 1985Assignee: BASF AktiengesellschaftInventors: Andreas Henne, Anton Hesse, Guenter Heil, Gunnar Schornick
-
Patent number: 4522942Abstract: A compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower cycloalkyl group, a lower cycloalkyl(lower)alkyl group, a halo(lower)alkyl group, a lower alkoxy(lower)alkyl group, a di(lower)alkoxy(lower)alkyl group, a cyano(lower)alkyl group, a lower alkylthio(lower)alkyl group, a lower alkynylthio(lower)alkyl group, a lower dioxothiacycloalkyl group, a lower thiacycloalkyl group, a lower oxacycloalkyl group, a lower oxacycloalkyl(lower)alkyl group or a thienyl(lower)alkyl group, R.sub.2 is a lower alkyl group and R.sub.3 is a 3,5-dimethoxyphenyl group, a 3,4-methylenedioxyphenyl group or a 4,5-methylenedixoy-2-nitrophenyl group, which is useful as a fungicide.Type: GrantFiled: June 2, 1983Date of Patent: June 11, 1985Assignee: Sumitomo Chemical Company, LimitedInventors: Hideo Kohsaka, Sasaki Mitsuru, Yukio Ishiguri
-
Patent number: 4522817Abstract: A fungicidal composition which comprises as an active ingredient a fungicidally effective amount of a phosphoramidothionate of the formula: ##STR1## wherein R.sub.1 is a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower cycloalkyl group, a lower cycloalkyl(lower)alkyl group, a halogen atom-substituted lower alkyl group, a lower alkoxy(lower)alkyl group, a di(lower)alkoxy(lower)alkyl group, a cyano group-substituted lower alkyl group, a lower alkylthio(lower)alkyl group, a lower dioxothiacycloalkyl group, a lower thiacycloalkyl group, a lower oxacycloalkyl group, a furanyl(lower)alkyl group or a thiophenyl(lower)alkyl group, R.sub.2 is a lower alkyl group and R.sub.3 is a lower alkyl group or a lower alkoxy group, and an inert carrier or diluent.Type: GrantFiled: March 14, 1983Date of Patent: June 11, 1985Assignee: Sumitomo Chemical Company, LimitedInventors: Hideo Kohsaka, Mitsuru Sasaki, Yukio Ishiguri
-
Patent number: 4508731Abstract: Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or .alpha.-naphthyl, each of which is further substituted,R.sub.1 is 2-furyl, 2-tetrahydrofuryl, alkenyl, cyclopropyl, .beta.-alkoxyethyl, hydroxymethyl, triazolylmethyl, imidazolylmethyl, pyrazolylmethyl, alkylsulfinyl, alkylsulfonyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, alkylsulfinyloxy, dialkylaminosulfinyloxy, phosphoric or thiophosphoric esters or amides, or alkylcarbonyloxy, andR.sub.9 is hydrogen or methyl,are microbicidally, in particular fungicidally active. The preferred compounds are those in which Ar is 2-methylphenyl, 2-methoxyphenyl, 2-chlorophenyl or .alpha.-naphthyl, each of which is further substituted by azido, and R.sub.9 is hydrogen.Type: GrantFiled: February 13, 1984Date of Patent: April 2, 1985Assignee: Ciba Geigy CorporationInventors: Peter Riebli, Hanspeter Fischer, Rudolph C. Thummel, Adolf Hubele
-
Patent number: 4482718Abstract: The present invention provides a process for the preparation of 2-(thien-2-yl)- and 2-(thien-3-yl)-ethylamine derivatives of the general formula: ##STR1## in which R.sub.1, in the 2-, 3-, 4- or 5-position, is a hydrogen or halogen atom, a nitro, carboxyl, cyano or amino group, a linear or branched alkyl or alkoxy radical or a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or polysubstituted, the aminoethyl chain is in the 2- or 3-position, R.sub.2, R.sub.3 and R.sub.4, which are the same or different, are hydrogen atoms or heterocyclic or non-heterocyclic aromatic radicals, which are optionally mono- or polysubstituted, and Ar is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or polysubstituted.Type: GrantFiled: June 29, 1982Date of Patent: November 13, 1984Assignee: SanofiInventors: Isaac Chekroun, Alain Heymes
-
Patent number: 4473560Abstract: Compounds of the formula ##STR1## wherein n is 0, 1, or 2;R.sup.1 is hydrogen or alkyl of 1-4 carbon atoms;R.sup.2 is hydrogen, an alkali metal atom, an alkaline earth metal atom, or alkyl of 1-4 carbon atoms; andAr is phenyl; phenyl substituted by fluorine, chlorine, alkyl of 1-4 carbon atoms, or alkoxy of 1-4 carbon atoms; naphthyl; biphenyl; or thienyl;or when R.sup.2 is H, a physiologically acceptable salt thereof with an organic basehave valuable antiinflammatory properties.Type: GrantFiled: January 27, 1983Date of Patent: September 25, 1984Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Clemens Rufer, Irmgard Boettcher
-
Patent number: 4470934Abstract: New cyanoalkylphosphoric acid ester chlorides of the general formula ##STR1## in which R represents a hydrogen atom, an optionally substituted radical selected from alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl and aryl, or an optionally substituted heterocyclic radical,R.sup.1 represents an optionally substituted radical selected from alkyl, alkenyl, alkinyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkylthio, alkenylthio, alkinylthio, arylthio, aralkylthio, alkylamino (monoalkylamino or dialkylamino), arylamino or aralkylaminoand X represents oxygen or sulphurare obtained by the reaction of a phosphoric acid dichloride of the general formula ##STR2## with an aldehyde of the general formulaR--CHO (III)in the presence of an approximately equimolar quantity of a water-soluble cyanide. The compounds of the formula (I) can be used as intermediate products for the preparation of insecticides.Type: GrantFiled: March 14, 1983Date of Patent: September 11, 1984Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kr/u/ ger, Hans-Joachem Riebel, Ingeborg Hammann, Berhard Homeyer, Wilhelm Stendel
-
Patent number: 4461764Abstract: Compounds of the formula: ##STR1## wherein X is sulfur or oxygen; R.sub.1 is lower alkyl; R.sub.2 is lower alkyl, lower straight chain alkoxy, lower alkylthio, phenyl or the group --NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl, provided that when X is oxygen, R.sub.2 is not phenyl, are pesticidal, exhibiting activity against pests such as plant fungal diseases and, in many cases, insects.Type: GrantFiled: September 22, 1982Date of Patent: July 24, 1984Assignee: Chevron Research CompanyInventor: Philip S. Magee
-
Patent number: 4448773Abstract: Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or .alpha.-naphthyl, each of which is further substituted,R.sub.1 is 2-furyl, 2-tetrahydrofuryl, alkenyl, cyclopropyl, .beta.-alkoxyethyl, hydroxymethyl, triazolylmethyl, imidazolylmethyl, pyrazolylmethyl, alkylsulfinyl, alkylsulfonyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, alkylsulfinyloxy, dialkylaminosulfinyloxy, phosphoric or thiophosphoric esters or amides, or alkylcarbonyloxy,R.sub.7 is hydrogen or optionally-substituted methyl or ethyl, andR.sub.8 is alkyl optionally substituted by alkoxy,are microbicidally, in particular fungicidally, active. Preferred compounds are those in which Ar is 2-methylphenyl, 2-methoxyphenyl, 2-chlorophenyl or .alpha.-naphthyl, each of which is further substituted by azido, and each of R.sub.7 and R.sub.8 is methyl.Type: GrantFiled: April 22, 1982Date of Patent: May 15, 1984Assignee: Ciba-Geigy CorporationInventors: Peter Riebli, Hanspeter Fischer, Rudolph C. Thummel, Adolf Hubele
-
Patent number: 4432972Abstract: Phosphonamidates of the formula ##STR1## wherein X is an amino acid or ester. These compounds possess angiotensin converting enzyme inhibition activity and enkephalinase inhibition activity. Thus they are useful as hypotensive and analgesic agents.Type: GrantFiled: December 27, 1982Date of Patent: February 21, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
-
Patent number: 4425281Abstract: A composition of matter of the formula ##STR1## where M is Cu(I) or Ag(I); R.sup.1 is C.sub.1 -C.sub.6 fluoroalkyl, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.6 heterocycle containing O, S or N or C.sub.6 -C.sub.10 aryl; R.sup.2 is H or C.sub.1 -C.sub.6 alkyl, with the proviso that R.sup.1 and R.sup.2 together with the carbons to which they are attached may be joined together to form a C.sub.6 ring; L is an unsaturated hydrocarbon containing at least one non-aromatic unsaturation; x and y are 1 or 2; and n is from 1 to 8.Type: GrantFiled: July 13, 1981Date of Patent: January 10, 1984Assignee: Exxon Research and Engineering Co.Inventor: Gerald Doyle
-
Patent number: 4424213Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.Type: GrantFiled: November 2, 1981Date of Patent: January 3, 1984Assignee: SDS Biotech CorporationInventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
-
Patent number: 4416833Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: November 26, 1982Date of Patent: November 22, 1983Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
-
Patent number: 4416832Abstract: New cyanoalkylphosphoric acid ester chlorides of the general formula ##STR1## in which R represents a hydrogen atom, an optionally substituted radical selected from alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl and aryl, or an optionally substituted heterocyclic radical,R.sup.1 represents an optionally substituted radical selected from alkyl, alkenyl, alkinyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkylthio, alkenylthio, alkinylthio, arylthio, aralkylthio, alkylamino (monoalkylamino or dialkylamino), arylamino or aralkylamino and X represents oxygen or sulphurare obtained by the reaction of a phosphoric acid dichloride of the general formula ##STR2## with an aldehyde of the general formulaR--CHO (III)in the presence of an approximately equimolar quantity of a water-soluble cyanide. The compounds of the formula (I) can be used as intermediate products for the preparation of insecticides.Type: GrantFiled: January 28, 1982Date of Patent: November 22, 1983Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Hans-Jochem Riebel, Ingeborg Hammann, Bernhard Homeyer, Wilhelm Stendel
-
Patent number: 4416831Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: November 1, 1982Date of Patent: November 22, 1983Assignee: E. R. Squibb & Sons, Inc.Inventor: Edward W. Petrillo, Jr.
-
Patent number: 4410518Abstract: A novel class of chemical compounds useful as pesticides consists of N-phosphinoaminosulfinylcarbamate esters. The preparation of these compounds and their formulation to control insects are exemplified.Type: GrantFiled: March 22, 1982Date of Patent: October 18, 1983Assignee: Regents of the University of CaliforniaInventors: Tetsuo R. Fukuto, Hiroki Ohta
-
Patent number: 4405355Abstract: Compounds of the formula ##STR1## wherein R is aliphatic hydrocarbyl, alicyclic hydrocarbyl or aryl suitably substituted, if desired, or a heterocyclic group, R.sup.1 is hydrogen or alkyl, R.sup.2 is alkyl or alkoxy, R.sup.3 is ##STR2## wherein a is 0 or 1, R.sup.4 is hydrogen or CW'.sub.3, the W' being hydrogen or halogen, Z is halogen and X is halogen, hydroxy, alkoxy, acetoxy, carbethoxyalkoxy, phenoxy, alkylthio, carbethoxyalkylthio, phenylthio, phosphono, dithiophosphonoxy, phosphoramido, isocyanato, isothiocyanato, alkyl- and dialkylthiocarbamoylthio, alkyl- and dialkylcarbamoyloxy, alkylsulfonyl, etc., have herbicidal activity.Type: GrantFiled: January 26, 1981Date of Patent: September 20, 1983Assignee: Chevron Research CompanyInventor: Malcolm S. Singer
-
Patent number: 4395275Abstract: Alkylphosphonate mono and diesters of N-phosphonomethylglycine are disclosed which are useful as herbicides. This invention further relates to herbicidal compositions containing such alkylphosphonate mono and diesters of N-phosphonomethylglycine and to herbicidal methods employing such compounds and compositions.Type: GrantFiled: June 19, 1981Date of Patent: July 26, 1983Assignee: Monsanto CompanyInventor: William R. Purdum
-
Patent number: 4381297Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: May 4, 1981Date of Patent: April 26, 1983Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
-
Patent number: 4374040Abstract: Aminoalkylenephosphonic acids and their alkali metal salts prepared by a reaction utilizing a primary or secondary tetrahydrothiophenamine 1,1-dioxide or the hydrochloride thereof, an aldehyde or a ketone, and orthophosphorous acid are useful in the control of scale and sludge deposition in aqueous systems. When used in combination with known corrosion inhibitors they show synergistic results in inhibiting corrosion of metal surfaces in contact with an aqueous system that is normally corrosive to such metals.Type: GrantFiled: August 19, 1980Date of Patent: February 15, 1983Assignee: Buckman Laboratories, Inc.Inventors: Joseph G. E. Fenyes, John D. Pera
-
Patent number: 4374131Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: April 27, 1981Date of Patent: February 15, 1983Assignee: E. R. Squibb & Sons, Inc.Inventor: Edward W. Petrillo, Jr.
-
Patent number: 4354975Abstract: This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates using as intermediates corresponding phosphorus derivatives of aminothiocarbamic halides. The carbamates are useful as pesticides against insects, mites, and nematodes. Two processes for preparing the corresponding intermediates are described. One preparation generally reacts an appropriate N-chlorothiophosphoramide with N-methylcarbamoyl halide. The other preparation generally reacts an N-chlorothiomethylcarbamoyl halide with an appropriate phosphoramide. The intermediate will react with various alcohols to produce the desired carbamates in the process of the invention.Type: GrantFiled: July 21, 1980Date of Patent: October 19, 1982Assignee: The Upjohn CompanyInventor: Stephen J. Nelson
-
Patent number: 4324744Abstract: Acylphosphine oxide compounds of the general formula ##STR1## where R.sup.1 is alkyl, cyclohexyl, cyclopentyl, aryl which is unsubstituted or substituted by halogen, alkyl or alkoxy, or an S-containing or N-containing five-membered or six-membered heterocyclic radical,R.sup.2 has one of the meanings of R.sup.1 (but R.sup.1 and R.sup.2 may be identical or different), or is alkoxy, aryloxy or aralkoxy, or R.sup.1 and R.sup.2 together from a ring, andR.sup.3 is straight-chain or branched alkyl of 2 to 18 carbon atoms, a cycloaliphatic radical of 3 to 12 carbon atoms, phenyl or naphthyl which are alkyl-, alkoxy- or thioalkoxy-substituted, or an S-containing or N-containing five-membered or six-membered heterocyclic radical, and may contain additional functional groups, or is the group ##STR2## where R.sup.1 and R.sup.2 have the above meanings and X is phenyl or an aliphatic or cycloaliphatic divalent radical of 2 to 6 carbon atoms,and one or more of the radicals R.sup.1 to R.sup.Type: GrantFiled: May 9, 1980Date of Patent: April 13, 1982Assignee: BASF AktiengesellschaftInventors: Peter Lechtken, Ingolf Buethe, Anton Hesse
-
Patent number: 4298738Abstract: Acylphosphine oxide compounds of the general formula ##STR1## where R.sup.1 is alkyl, cyclohexyl, cyclopentyl, aryl which is unsubstituted or substituted by halogen, alkyl or alkoxy, or an S-containing or N-containing five-membered or six-membered heterocyclic radical,R.sup.2 has one of the meanings of R.sup.1 (but R.sup.1 and R.sup.2 may be identical or different) or is alkoxy, aryloxy or aralkoxy, or R.sup.1 and R.sup.2 together form a ring andR.sup.3 is an at least disubstituted phenyl, pyridyl, furyl or thienyl radical which carries, at least at the two carbon atoms adjacent to the linkage point of the carbonyl group, the substituents A and B, which may be identical or different, and each of which is alkyl, alkoxy or alkythio of 1 to 6 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, phenyl or halogen, or R.sup.3 is .alpha.-naphthyl substituted by A and B at least in the 2- and 8-positions or is .beta.Type: GrantFiled: May 12, 1980Date of Patent: November 3, 1981Assignee: BASF AktiengesellschaftInventors: Peter Lechtken, Ingolf Buethe, Manfred Jacobi, Werner Trimborn
-
Patent number: 4268506Abstract: New thienylmethyl-thiophosphoric acid esters of the formula ##STR1## where R.sup.1 denotes methyl or ethyl, R.sup.2 denotes linear or branched alkyl of a maximum of 5 carbon atoms, X denotes oxygen or sulfur, Y denotes sulfur or --NH--, Z denotes halogen, and n denotes one of the integers 0, 1, 2 and 3, which are effective against pests, especially insects, Arachnida and Nemathelminthes, and pesticides containing these compounds as active ingredients.Type: GrantFiled: July 5, 1979Date of Patent: May 19, 1981Assignee: BASF AktiengesellschaftInventors: Annegrit Baumann, Heinrich Adolphi