Oxygen Bonded Directly At The 16-position Patents (Class 552/564)
  • Patent number: 8586770
    Abstract: The invention relates to methods to manipulate stem cells in vivo and in vitro to treat, e.g., a condition where cell or tissue repair is needed.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: November 19, 2013
    Assignee: Harbor Therapeutics, Inc.
    Inventor: James M. Frincke
  • Patent number: 8258124
    Abstract: The subject matter of this application relates to the combination of ciclesonide or an epimer thereof with R,R-formoterol or a salt, or a hydrate of a salt thereof.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: September 4, 2012
    Assignee: Nycomed GmbH
    Inventors: Christian Weimar, Klaus Dietzel, Helgert Müller, Degenhard Marx
  • Patent number: 7879833
    Abstract: The invention relates to the combination of ciclesonide with formoterol.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: February 1, 2011
    Assignee: NYCOMED GmbH
    Inventors: Christian Weimar, Klaus Dietzel, Helgert Müller, Degenhard Marx
  • Patent number: 6506223
    Abstract: A fuel pellet is produced by the combination of organic waste material with a binder obtained by direct liquefaction and/or fast pyrolysis of biomass material. Direct liquefaction and fast pyrolysis are carried out according to known liquefaction processes. The liquefied bio-binder base is mixed with additives, if desired, such as petroleum asphalt and cross-linking agents, in order to modify its characteristics to meet specific needs of particular applications, and the resulting mixture is mixed with organic-waste material preheated to 100° C. or more and allowed to react at about 150-200° C. Combustible extenders and fillers, reinforcing fibers, and cross-linking agents may be mixed with the organic material or the bio-binder base to provide additional specific properties to the mixture. The resulting well mixed mass is then pelletized or otherwise molded in conventional equipment.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: January 14, 2003
    Assignee: Waste Technology Transfer, Inc.
    Inventor: Donald H. White
  • Patent number: 6043603
    Abstract: The invention relates to a low-pressure discharge lamp with at least one porting element (12) placed inside a discharge vessel (10). Said supporting element is provided with a mercurial coating (13) and is coated with a getter material (14). The coated surfaces of the supporting element (12) are inclined at an angle of at least 30 degrees in relation to the longitudinal axis (A--A) of the discharge vessel (10).
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: March 28, 2000
    Assignee: Patent-Treuhand-Gesellschaft fuer elektrische Gluehlampen mbH
    Inventor: Erolf Weinhardt
  • Patent number: 5710293
    Abstract: The present invention relates to a method of using a perchloric acid catalyzed reaction to make acyl derivatives of norprogesterone compounds and, in particular, 16-methylene-17.alpha.-hydroxy-19-norpregn-4-ene-3,20-dione.
    Type: Grant
    Filed: October 13, 1995
    Date of Patent: January 20, 1998
    Assignee: The Population Council, Center for Biomedical Research
    Inventor: Fang Li
  • Patent number: 5707984
    Abstract: Disclosed are steroid nitrite/nitrate ester derivatives of formula I: ##STR1## wherein, the substituents are as defined in the specification and their use in the treatment of inflammatory diseases.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: January 13, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec
  • Patent number: 5670676
    Abstract: Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethylformamide; at a temperature within the range of about -78.degree. to about 0.degree. C.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 23, 1997
    Assignee: Schering Corporation
    Inventors: Richard W. Draper, Eugene J. Vater
  • Patent number: 5616573
    Abstract: Glucocorticoids of general formula IR--Val--O--GC (II),are described,in whichO-GC is the radical of a 21-hydroxycorticoid that has an antiinflammatory action,Val represents a valine radical in the 21-position of the corticoid andR means a hydrogen atom or a hydrocarbon radical with up to 32 carbon atoms that is optionally substituted by hydroxy groups, amino groups, oxo groups and/or halogen atoms and/or interrupted by oxygen atoms, SO.sub.2 groups and/or NH groups and their salts.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: April 1, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Hans J. Zentel, Michael Topert, Henry Laurent, Thomas Brumby, Peter Esperling
  • Patent number: 5602248
    Abstract: Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethyl formamide; at a temperature within the range of about -78.degree. to about 0.degree. C., under anhydrous conditions under an inert atmosphere.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: February 11, 1997
    Assignee: Schering Corporation
    Inventors: Richard W. Draper, Eugene J. Vater
  • Patent number: 5451690
    Abstract: A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsulfonyl and arylsulfonyl of up to 8 carbon atoms and their use to prepare substituted 16,17-methylenedioxy-steroids and novel intermediates.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: September 19, 1995
    Assignee: Roussel Uclaf
    Inventors: Luc Devocelle, Philippe Mackiewicz
  • Patent number: 5352808
    Abstract: A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.2 is alkyl of 1 to 4 carbon atoms and the A, B, C and D rings are optionally substituted by at least one member of the group consisting of optionally protected --OH or .dbd.0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms comprising reacting a compound of the formula ##STR2## wherein R.sub.1 and R.sub.2 and the A, B, C and D rings are defined as above with an oxidizing agent in the presence of water and an at least partially water-miscible solvent to obtain a compound of the formula ##STR3## wherein R.sub.1 and R.sub.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: October 4, 1994
    Assignee: Roussel Uclaf
    Inventors: Jean Buendia, Michel Vivat
  • Patent number: 4977255
    Abstract: 17.beta.-Cyano-17.alpha.-hydroxy steroids (I) are transformed to 17.alpha.-halo silyl ethers (II) which are intermediates useful in the production of progesterones (V), 17-hydroxyprogesterones (VI), corticoids (VII) and 21-halo corticoids (III) which can readily be transformed to corticoids (VII).
    Type: Grant
    Filed: April 7, 1989
    Date of Patent: December 11, 1990
    Assignee: The Upjohn Company
    Inventors: Douglas A. Livingston, Bruce A. Pearlman, Scott Denmark
  • Patent number: 4913852
    Abstract: Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of .DELTA.-4-pregnene-3,20-dione or with derivatives of .DELTA.-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucocorticoidal and anti-inflammatory properties have been prepared and tested. Pharmaceutical compositions, medicaments containing them as well as their applications are claimed, particularly in the cutaneous and ophthalmic fields.
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: April 3, 1990
    Inventors: Catherine Milioni, Constantin Efthyimiopoulos, Bernard Koch, Louis Jung, Jean Jung