Oxygen Bonded Directly At The 3-, 11- And 17-positions (e.g., 1-androstene 3,11,17-triones, Etc.) Patents (Class 552/619)
  • Patent number: 10238236
    Abstract: An apparatus for converting a barbecue into a pizza cooking oven includes an open door frame and vertical side panels pivotally attached to the vertical side posts of the open door frame. The side panels can be pivotally adjusted on the open door frame to extend rearward of the open door frame at different pivot positions. When the side panels are extended rearward of the open door frame, the bottom edges of the side panels provide a support base for setting the apparatus onto the top rim of a bottom bowl of a barbecue and the top edges of the side panels support a cover of a barbecue in an elevated position above the bottom bowl of the barbecue. The elevation of the cover creates an expanded cooking chamber above the bottom bowl of the barbecue and the open door frame provides access to the expanded cooking chamber.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 26, 2019
    Assignee: Charcoal Companion Incorporated
    Inventors: Cory Thomas Borovicka, Kwame Phillips-Solomon
  • Publication number: 20130267721
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Application
    Filed: January 28, 2013
    Publication date: October 10, 2013
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • Patent number: 8022234
    Abstract: The invention provides compositions comprising formula 1 steroids, e.g., 16?-bromo-3?-hydroxy-5?-androstan-17-one hemihydrate and one or more excipients, including compositions that comprise a liquid formulation comprising less than about 3% v/v water. The compositions are useful to make improved pharmaceutical formulations. The invention also provides methods of intermittent dosing of steroid compounds such as analogs of 16?-bromo-3?-hydroxy-5?-androstan-17-one and compositions useful in such dosing regimens. The invention further provides compositions and methods to inhibit pathogen replication, ameliorate symptoms associated with immune dysregulation and to modulate immune responses in a subject using the compounds. The invention also provides methods to make and use these immunomodulatory compositions and formulations.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: September 20, 2011
    Assignee: Harbor BioSciences, Inc.
    Inventor: James M. Frincke
  • Publication number: 20080153797
    Abstract: The invention relates to methods to identify compounds that can treat autoimmune conditions and treat specified clinical disorders such as multiple sclerosis, ulcerative colitis or arthritis. Compounds include 17?-ethynylandrost-5-ene-3?,11?,7?,17?-tetrol, 4?-acetoxy-17?-ethynylandrost-5-ene-3?,7?,17?-triol, 17?-ethynylandrost-5-ene-3?,4?,7?,17?-tetrol, 17?-ethynylandrost-5-ene-3?,4?,7?,17?-tetrol and 17?-ethynylandrost-5-ene-3?,4?,17?-triol-7-one.
    Type: Application
    Filed: November 17, 2007
    Publication date: June 26, 2008
    Inventors: James M. Frincke, Christopher Reading, Dominick Auci, Clarence N. Ahlem
  • Publication number: 20080139519
    Abstract: The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.
    Type: Application
    Filed: May 17, 2005
    Publication date: June 12, 2008
    Inventors: Adrian Ashley, Paul Lamb, Donald MacDonald, John Miller, Martin J. Oliver, Mathew Pollard
  • Publication number: 20040087562
    Abstract: This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, 1
    Type: Application
    Filed: March 21, 2003
    Publication date: May 6, 2004
    Inventor: Peter Guillaume Marie Wuts
  • Publication number: 20040010138
    Abstract: This invention relates to a process for the production of 7&agr;-methyl steroids of general formula I, 1
    Type: Application
    Filed: March 21, 2003
    Publication date: January 15, 2004
    Applicant: Schering AG
    Inventors: Marc Willuhn, Orlin Petrov, Evelin Amoulong-Kirstein, Stephan Vettel, Agnes Matzeit
  • Patent number: 5892069
    Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: April 6, 1999
    Assignee: The Children's Medical Center Corporation
    Inventors: Robert John D'Amato, Moses Judah Folkman
  • Patent number: 5831104
    Abstract: The invention is directed to novel steroid intermediate products of general formula I ##STR1## The steroid intermediate products which can be isolated according to the invention are suitable for the synthesis of 13-ethyl-11-methylene-18,19-bisnor-17.alpha.-pregn-4-en-20-in-17-ol (desogestrel).Further, processes for producing the steroid intermediate products of general formula I are described. The olefination of the 11-oxo steroids is carried out under the influence of ultrasound.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: November 3, 1998
    Assignee: Jenapharm GmbH
    Inventors: Sven Ring, Gerhard Teichmueller, Gisela Weber, Sigfrid Schwarz, Bernd Erhart, Bernd Undeutsch, Harald Raethe, Peter Moellmann, Carmen Pfeiffer, Hans-Joachim Palme
  • Patent number: 5438134
    Abstract: The unsaturated 17.alpha.-cyanomethyl-17.beta.-hydroxy steroids of the formula I, ##STR1## in which R.sub.1 =Me, Eth; R.sub.2 =H, Me; R.sub.3 =H, OH, an acetoxy or alkoxy group; R.sub.4 =H, R.sub.5 =OH, an acetoxy, alkoxy group of R.sub.4 and R.sub.5 together represent a keto- or ketal group and double bonds are contained in the basic structure of the steroid, particularly between the 15 and 16 position in the steroid ring, from unsaturated 17-ketosteroids of the general formula II as described herein with the aforementioned meanings of R.sub.1 to R.sub.5 by reacting the unsaturated 17-ketosteroids with LiCH.sub.2 CN and subsequently hydrolyzing.The compounds of formula I are pharmacologically interesting steroid compounds or also intermediate products for the synthesis of highly-effective steroid products which can be used in human and veterinary medicine for the treatment of endocrine disorders and for reproductive control based on their specific hormonal/anti-hormonal actions.
    Type: Grant
    Filed: June 1, 1993
    Date of Patent: August 1, 1995
    Assignee: Jenapharm GmbH
    Inventors: Gerhard Teichmuller, Gerd Muller
  • Patent number: 5426198
    Abstract: The present invention involves improved processes for the dehalogenation of 9.alpha.-halosteroids (I) ##STR1## to produce the corresponding 11.beta.-hydroxy steroids (II) ##STR2## which are known to be useful as pharmaceutical, where the improvements comprise (1) adding the 9.alpha.-halo steroid (I) to the chromium and (2) using catalytic amounts of chromium in the presence of a means of converting chromium (II) to chromium (III).
    Type: Grant
    Filed: January 31, 1990
    Date of Patent: June 20, 1995
    Assignee: The Upjohn Company
    Inventors: Joel E. Huber, Jeffrey A. Fleming
  • Patent number: 5292906
    Abstract: Novel tricyclic steroid analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural formulas: ##STR1## wherein R.sub.1 =H or C.sub.1 -C.sub.4 alkyl or fluoroalkyl;R.sub.2 =H or C.sub.1 -C.sub.4 alkyl or fluoroalkyl, in which R.sub.1 and R.sub.2 can be the same or different;R.sub.3 =H or CH.sub.3 ;R.sub.4 =H or CH.sub.3, in which R.sub.3 and R.sub.4 can be the same or different;R.sub.5 =H;R.sub.6 =H;R.sub.5,R.sub.6 =.dbd.O(carbonyl);R.sub.7 =H;R.sub.8 =a hydrogen bond accepting group.R.sub.7,R.sub.8 =.dbd.O(carbonyl); andR'=an ester group.
    Type: Grant
    Filed: January 14, 1993
    Date of Patent: March 8, 1994
    Assignee: Washington University
    Inventors: Douglas F. Covey, Yuefei Hu, Charles F. Zorumski