Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
April 25, 1997
Date of Patent:
April 6, 1999
The Children's Medical Center Corporation
Robert John D'Amato, Moses Judah Folkman