Additional Carboxamide Group Containing (e.g., Carbamates, Ureas, Etc.) Patents (Class 554/56)
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Patent number: 11453791Abstract: The present invention relates to diamide-polyolefin wax mixture comprising one or more diamides (A) and one or more polyolefin waxes (B), where the diamide or diamides (A) possess a structure of the formula X1—CO—NH—Y—NH—CO—X2, in which X1 and X2 are identical or different and are linear or branched, saturated or unsaturated, optionally substituted hydrocarbon radicals having 3 to 29 carbon atoms, and Y is a divalent organic radical which is selected from the group consisting of aliphatic radicals having 2 to 26 carbon atoms, aromatic radicals having 6 to 24 carbon atoms or araliphatic radicals having 7 to 24 carbon atoms, and Y optionally comprises secondary or tertiary amino groups, and the polyolefin wax or waxes (B) carry one or more carboxyl groups and have an acid number of 3 to 50, and are homopolymers or copolymers of at least one ethylenically unsaturated olefin monomer, where the diamide or diamides (A), based on the total weight of the diamide-polyolefin wax mixture, are present in an amount of 20Type: GrantFiled: February 7, 2018Date of Patent: September 27, 2022Assignee: BYK-Chemie GmbHInventors: Christiane Knappke-Bongartz, Rene Nagelsdiek, Sylvia Bühne, Meike Johann, Agnetha Klein, Andre Tiemann
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Patent number: 9783692Abstract: The present disclosure provides dimeric fluorosurfactants related methods and ink-jet inks incorporating such fluorosurfactants. As such, an ink-jet ink can comprise a liquid vehicle; a non-ionic fluorosurfactant dimer having the structure CF3(CF2)x(CH2)y(CR2CR2O)z-A-(OCR2CR2)a(CH2)b(CF2)cCF3, where R is independently H or methyl, A is a bridging unit containing aliphatic or aromatic functionality, x is 3 to 18, y is 0 to 8, z is 0 to 100, a is 0 to 100, b is 0 to 8, and c is 3 to 18; and a colorant.Type: GrantFiled: September 14, 2012Date of Patent: October 10, 2017Assignee: Hewlett-Packard Development Company, L.P.Inventors: Phillip C. Cagle, Sergiy Peleshanko
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Publication number: 20150031892Abstract: Sphingolipid metabolite mimetics and methods of synthesizing them are provided. The sphingolipid metabolite mimetics are shown to be effective at inducing apoptosis in various types of tumor cells. Further, the sphingolipid metabolite mimetics are shown to be effective at sensitizing multiple types of tumor cells to TRAIL-induced apoptosis. Formulations containing one or more sphingolipid metabolite mimetics and, optionally, one or more cell death receptor agonists are provided. Methods of treating cancer in a subject in need thereof are provided using one or more sphingolipid metabolite mimetics.Type: ApplicationFiled: October 10, 2014Publication date: January 29, 2015Inventors: Feiyan Liu, Kebin Liu, Zhizhen Huang, Ping Wu
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Publication number: 20140296344Abstract: There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.Type: ApplicationFiled: June 13, 2014Publication date: October 2, 2014Inventor: Samuel FORTIN
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Publication number: 20130190327Abstract: The invention relates to bis-fatty acid conjugates; compositions comprising an effective amount of a bis-fatty acid conjugate; and methods for treating or preventing cancer, a metabolic disease or a neurodegenerative disease comprising the administration of an effective amount of a bis-fatty acid conjugate.Type: ApplicationFiled: February 25, 2011Publication date: July 25, 2013Applicant: CATABASIS PHARMACEUTICALS INCInventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu
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Publication number: 20130123485Abstract: The present invention provides cationic lipids, methods for preparing the same, and delivery systems comprising the same. The present invention can provide cationic lipids which enhance the efficiency of intracellular or in vivo delivery of multiple-anionic target compounds such as drugs, anticancer agents, nucleic acids, etc., have no intracellular toxicity, but show increased stability, methods for preparing the same, and delivery systems comprising the same.Type: ApplicationFiled: July 12, 2011Publication date: May 16, 2013Inventors: Myung-Ok Park, Eun Young Yoon
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Publication number: 20130065934Abstract: The invention relates to fatty acid COX inhibitor derivatives; compositions comprising an effective amount of a fatty acid COX inhibitor derivative; and methods for treating or preventing a metabolic, autoimmune, inflammatory, or neurodegenerative disorder comprising the administration of an effective amount of a fatty acid COX inhibitor derivative.Type: ApplicationFiled: March 4, 2011Publication date: March 14, 2013Applicant: CATABASIS PHARMACEUTICALS, INC.Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu
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Publication number: 20110082210Abstract: The invention relates to fatty acid fibrate derivatives; compositions comprising an effective amount of a fatty acid fibrate derivative; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid fibrate derivative.Type: ApplicationFiled: October 5, 2010Publication date: April 7, 2011Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu
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Publication number: 20100240883Abstract: New prodrugs are derived from highly water soluble parent drugs that exist as primary or secondary amines in their parent form. Lipophilic carrier groups are bonded to the parent drug via an amide linkage with additional linker elements between the amide group and the carrier group.Type: ApplicationFiled: March 17, 2010Publication date: September 23, 2010Inventors: Nian Wu, Brian Charles Keller
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Patent number: 7589065Abstract: The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.Type: GrantFiled: August 20, 2002Date of Patent: September 15, 2009Assignee: Max-Planck Gesellschaft zur Forderung der Wissenschaften, C.V.Inventors: Cordelia Schiene-Fischer, Gunter Fischer, Judith Maria Habazettl, Gerhard Küllertz
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Patent number: 7015340Abstract: The invention relates to a heat-sensitive compound having the property of being soluble in water below a critical temperature Tc and insoluble in water above this temperature Tc, this property being thermally reversible, characterized in that it comprises a first amphiphilic and thermally reversible part corresponding to one of the following formulae (I) and (II): in which i is an integer ranging from 1 to 20 and j is an integer ranging from 3 to 30. This compound can be used to extract a chemical entity, such as uranium.Type: GrantFiled: September 6, 2002Date of Patent: March 21, 2006Assignee: Commissariat a L'Energie AtomiqueInventors: Charles Madic, Laurence Berthon, Nicole Zorz, Hélène Coulombeau, Fabienne Testard, Thomas Zemb, Sébastien Gibanel, Chantal Larpent, Krystyna Baczko
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Patent number: 6949663Abstract: As a negatively charged lipid that can stably add negative charges to the surface of vesicles without side effects, the carboxyl acid-type lipid of the following general formula [1]: [wherein R1, R2 and R3 represent substituents of which one is represented by the following general formula [X]: (wherein M is a hydrogen atom or monovalent cation, and m is an integer of 1 to 5 that represents the methylene chain length), and the other two are chained hydrocarbon groups; A1, A2 and A3 are the same or different substituents selected from the group consisting of C(O)O, CONH or NHCO; and n is an integer of 1 to 3 that represents the methylene chain length) is provided.Type: GrantFiled: November 9, 2001Date of Patent: September 27, 2005Assignee: Japan Science and Technology CorporationInventors: Eishun Tsuchida, Shinji Takeoka, Keitaro Sou, Haruki Ohkawa, Katsura Mori
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Patent number: 6921747Abstract: The present invention provides a basic amino acid derivative represented by the formula (1): The present invention also provides a method of making a gelled product by employing the aforementioned compound, as well as a gel, perfumery, and/or cosmetic containing the same.Type: GrantFiled: February 13, 2004Date of Patent: July 26, 2005Assignee: Ajinomoto Co., Inc.Inventors: Kenji Hanabusa, Masahiro Suzuki
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Patent number: 6864285Abstract: The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as agonists of the CB2 cannabinoid receptor and hence as drugs active in pathological conditions which can be controlled by stimulation and/or costimulation of this receptorType: GrantFiled: July 7, 1999Date of Patent: March 8, 2005Assignee: Innovet Italia S.r.l.Inventors: Cristina Comelli, Francesco Della Valle, Maria Federica Della Valle, Gabriele Marcolongo
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Patent number: 6600059Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.Type: GrantFiled: January 10, 2002Date of Patent: July 29, 2003Assignee: Virginia Commonwealth UniversityInventors: Richard C. Franson, Raphael M. Ottenbrite
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Publication number: 20020169326Abstract: The present invention relates to a novel fatty acid derivative of the following formula: 1Type: ApplicationFiled: May 6, 2002Publication date: November 14, 2002Applicant: FUJISAWA PHARMACEUTICAL COMPANY, LTD.Inventors: Naoki Fukami, Seiji Yoshimura, Keisuke Imai, Keiji Hemmi, Mitsue Hemmi, Keiichiro Hemmi, Yusuke Hemmi
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Publication number: 20020151070Abstract: The invention relates to new lipid compounds of formula:Type: ApplicationFiled: December 19, 2001Publication date: October 17, 2002Inventors: Rainer Bischoff, Abdesslame Nazih, Yves Cordier
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Patent number: 6423855Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.Type: GrantFiled: January 12, 2000Date of Patent: July 23, 2002Assignee: Virginia Commonwealth UniversityInventors: Richard C. Franson, Raphael M. Ottenbrite
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Patent number: 6251931Abstract: Oleamide is an endogenous fatty acid primary amide that possesses sleep-inducing properties in animals and has been shown to effect seratonergic systems and block gap junction communication in a structurally specific manner. Certain agents can serve both as an oleamide agonist and as an inhibitor of fatty acid amide hydrolase. Fatty acid amide hydrolase is responsible for the rapid inactivation of oleamide in vivo. The structural features of oleamide required for inhibition of gap junction-mediated chemical and electrical transmission in rat glial cells are defined. Effective inhibitors fall into two classes of fatty acid primary amides of which oleamide and arachidonamide are the prototypical members. Of these two, oleamide constitutes the most effective and its structural requirements for inhibition of the gap junction are well defined.Type: GrantFiled: April 19, 2000Date of Patent: June 26, 2001Assignee: The Scripps Research InstituteInventors: Dale L. Boger, Norton B. Gilula, Richard A. Lerner, Benjamin F. Cravatt
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Patent number: 6239297Abstract: The present invention intends to provide a derivative of sphingosine analogue that is able to regulate the functions of sphigolipid, and its pharmaceutical compositions. The present invention is the derivatives of sphingosine analogues represented by the general formula (I) described below. In the formula, R1 and R2, which are the same or different each other, are hydrogen, alkyl groups having 1-4 carbon atoms, or acyl groups having 2-5 carbon atoms. R3 and R4, which are the same or different each other, are hydrogen or hydroxyl groups; or R3 and R4 make up a covalent bond. X1 is —(CH2)n—CO—NH—CH(R5)—R6 or —(CH2)m—O—CO—CH(R7)—R8.Type: GrantFiled: April 28, 2000Date of Patent: May 29, 2001Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Toru Kurome, Naoyuki Awazu, Ikunoshin Kato
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Patent number: 6235912Abstract: The present invention aims to provide a novel sphingosine analogue, which is useful as an intermediate for syntheses of novel lipid derivatives such as sphingolipid derivatives and the like that can regulate the effects of sphingolipid. The present invention relates to a sphingosine analogue represented by the general formula (I) described below. In the formula, as for Q1, Q2 and Q3, Q1 and Q2, which are the same or different each other, are hydrogen, alkyl groups having 1-4 of carbon atoms, acyl groups having 2-5 of carbon atoms, or protecting groups of the amino group, and Q3 is a hydrogen or a protecting group of the hydroxyl group; or Q2 and Q3 make up an isopropylidene group and Q1 is a hydrogen or a protecting group of the amino group. Q4 and Q5, which are the same or different each other, are hydroxyl groups, acyl groups having 2-5 of carbon atoms, —O—Q6, or hydrogen; or Q4 and Q5 make up a covalent bond. Q6 is a protecting group of the hydroxyl group.Type: GrantFiled: October 15, 1999Date of Patent: May 22, 2001Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Toru Kurome, Naoyuki Awazu, Ikunoshin Kato
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Patent number: 6096778Abstract: This invention relates to .alpha.-ketoamide inhibitors of multicatalytic protease (MCP), to compositions including such inhibitors, and to methods for the use of MCP inhibitors. The MCP inhibitors of the present invention are useful, for example, to retard loss of muscle mass incident to various physiological states.Type: GrantFiled: October 6, 1998Date of Patent: August 1, 2000Assignee: Cephalon, Inc.Inventors: Sankar Chatterjee, John P. Mallamo
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Patent number: 6060612Abstract: Disclosed herein is a ceramide-like compound having properties of the natural ceramides, and a method for producing the same, and a cosmetic composition containing the same as a active ingredient.Type: GrantFiled: December 10, 1997Date of Patent: May 9, 2000Assignee: Pacific CorporationInventors: Jong Eon Hong, Myeung Su Ku, Bo Sub Lee, Young Hun Byon, Duk Hee Kim, Sang Rhin Lee, Ok Sob Lee, Hae Kwang Lee, Jong Ho Park, Ki Wha Lee, Ki Tack Nam, Jong Il Kim, Hyun Jun Kim, Hey Jin Jung
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Patent number: 6054483Abstract: The invention relates to fatty acids conjugated to amino acids and their derivatives that elicit the production and/or release of plant volatiles compounds which attract and/or retain beneficial insects and deter herbivorous insect feeding. These conjugates also induce plants to increase production of pharmacologically important compounds such as taxol, increase fragrance of flowers, and increase production of plant essential oil. The invention also relates to methods for isolating the compounds from herbivorous insect oral secretions and to chemically synthesizing the compounds and their active derivatives.Type: GrantFiled: December 3, 1996Date of Patent: April 25, 2000Assignees: The United States of America as represented by the Secretary of Agriculture, Virginia Military Institute Research Laboratories, Inc.Inventors: James H. Tumlinson, III, Hans T. Alborn, John H. Loughrin, Theodoor C. J. Turlings, Tappey H. Jones
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Patent number: 6040339Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR2## wherein: A.sup.1 is a single bond, alkylene or alkenylene; A.sup.2 is or alkenylene; A.sup.3 is a single bond, alkyleneor alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or various other groups; R.sup.6 is alkyl or phenyl; R.sup.7 is hydrogen or alkyl; R.sup.8 is alkyl or various other groups; and n is 0 and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.Type: GrantFiled: May 28, 1998Date of Patent: March 21, 2000Assignee: Sankyo Company, LimitedInventors: Akira Yoshida, Kozo Oda, Takashi Kasai, Kousei Shimada, Hiroshi Kogen, Ichiro Hayakawa, Sadao Ishihara, Teiichiro Koga, Eiichi Kitazawa, Taro Tokui
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Patent number: 6040281Abstract: At least 5, preferably at least 30, in particular about 50, percent by weight of the alkali metal salts and/or triethanolamine salts of alkanoylamidocarboxylic acids of the general formula ##STR1## R.sup.1 denotes an alkanoyl or an alkanesulfonyl radical, each having 6 to 20 carbon atoms, ##STR2## R.sup.4 denotes a hydrogen atom; m is 2;n is 0 or 1, andz denotes an integer from 0 to 3;are used as antifoams in corrosion-inhibiting metal working compositions.Type: GrantFiled: July 5, 1998Date of Patent: March 21, 2000Assignee: Heinz BereuterInventors: Heinz Bereuter, Thomas Bereuter, Wolfgang Bereuter, Ingrid Kohlhaupt
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Patent number: 5855630Abstract: Multiple amide polyether alcohol compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each independently selected from the group consisting of hydrocarbyl of 2 to 100 carbon atoms and substituted hydrocarbyl of 2 to 100 carbon atoms; R.sub.3 and R.sub.4 are each independently selected from the group consisting of hydrocarbyl of 1 to 100 carbon atoms, substituted hydrocarbyl of 1 to 100 carbon atoms and polyoxyalkylene alcohol of 2 to 200 carbon atoms; R.sub.5 is selected from the group consisting of alkylene of 2 to 20 carbon atoms and alkylene of 2 to 20 carbon atoms having at least one methylene group replaced by at least one oxygen atom or at least one acylated nitrogen atom; x and y are each from 1 to 50 and the weight average molecular weight of the additive compound is greater than about 600 when used as gasoline additives are found to decrease intake valve deposits.Type: GrantFiled: September 19, 1997Date of Patent: January 5, 1999Assignee: Shell Oil CompanyInventors: Jiang-Jen Lin, Sarah Louise Weaver
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Patent number: 5801178Abstract: An aniline derivative of the formula (1) ##STR1## wherein R.sup.1 is an eicosapentaenoyl or docosahexaenoyl; R.sup.2 and R.sup.3 are each independently an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; R.sup.4 is a hydrogen atom, an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; and A is a single bond, --C(.dbd.O)NH--(CH.sub.2).sub.n --NH-- wherein n is 2 or 3, or a bivalent group of the following formula ##STR2## wherein m and p are each independently 0 or 1. The aniline derivative of the present invention has high inhibitory activity against and high selectivity for ACAT derived from macrophage and is useful as an agent for the prophylaxis and treatment of arteriosclerosis.Type: GrantFiled: February 7, 1996Date of Patent: September 1, 1998Assignees: Nippon Shoji Kaish Ltd., Sagami Chemical ResearchInventors: Kazunaga Yazawa, Kazuo Watanabe, Yasuharu Ijuin, Mayumi Shikano, Yasuji Soda, Tetsuya Kosaka, Naoto Matsuyama, Koji Mizuno
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Patent number: 5792880Abstract: The present Application relates to a process for the preparation of N-lauroyl-L-glutamic acid di-n-butylamide by reaction of N-lauroyl-L-glutamic acid dimethyl ester with n-butylamine in the presence of a hydrocarbon or hydrocarbon mixture as an auxiliary solvent.Type: GrantFiled: March 13, 1997Date of Patent: August 11, 1998Assignee: Hoechst AktiengesellschaftInventors: Fritz Engelhardt, Manfred Muller, Michael Wessling
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Patent number: 5659049Abstract: Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.Type: GrantFiled: June 6, 1995Date of Patent: August 19, 1997Assignee: Virginia Commonwealth UniversityInventors: Richard C. Franson, Raphael M. Ottenbrite
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Patent number: 5654452Abstract: Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific delivery to the liver. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm and having a composition simulating naturally-occuring chylomicron remnants.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Dung K. Hong
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Patent number: 5616745Abstract: New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6 R represents a radical ##STR2## (R.sub.1 and R.sub.2 : aliphatic radical containing 12 to 22 carbon atoms; R: hydrogen atom or alkyl radical optionally substituted with phenyl), or a radical ##STR3## (X=CH.sub.2, CO; R.sub.3 and R.sub.4 aliphatic radical containing 11 to 21 carbon atoms), their preparation and their use.The lipopolyamines of general formula (I) are especially useful as vectors for the transfection of eukaryotic cells.Type: GrantFiled: June 7, 1995Date of Patent: April 1, 1997Assignee: Centre National de la Recherche ScientifiqueInventors: Jean-Paul Behr, Jean-Philippe Loeffler
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Patent number: 5614649Abstract: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.Type: GrantFiled: November 3, 1995Date of Patent: March 25, 1997Assignee: Cephalon, Inc.Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
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Patent number: 5534197Abstract: Gemini polyhydroxy fatty acid amide compounds and laundry, cleaning, fabric and personal care compositions comprising these compounds.Type: GrantFiled: November 21, 1994Date of Patent: July 9, 1996Assignee: The Procter & Gamble CompanyInventors: Jeffrey J. Scheibel, Daniel S. Connor, Yi-Chang Fu
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Patent number: 5510531Abstract: A Novel N-substituted peptidyl compound represented by the general formula (1): ##STR1## where R.sub.1 is a straight-chained or branched acyl group having 2-10 carbon atoms, a branched, cyclic or bridged cyclic alkyloxycarbonyl group having 4-15 carbon atoms; a benzyloxycarbonyl group which is unsubstituted or substituted with a halogen atom, nitro group or methoxy group; a 2,2,2-trichloroethyloxycarbonyl group, a 2-(trimethylsilyl)ethyloxycarbonyl group, a p-toluensulfonyl group, an o-nitrophenylsulfenyl group, a diphenylphosphonothioyl group, a triphenylmethyl group, a 2-benzoyl-1-methylvinyl group;R.sub.2 is a hydrogen atom or when taken together with R.sub.1, may form a phthaloyl group;R.sub.3 is an isobutyl group, a n-butyl group or an isopropyl group;R.sub.4 is a butyl group, andR.sub.5 is a hydrogen atom;provided that R.sub.1 can be an unsubstituted benzyloxycarbonyl group only when R.sub.3 is a n-butyl group.Type: GrantFiled: October 5, 1994Date of Patent: April 23, 1996Assignee: Suntory LimitedInventors: Naoki Higuchi, Masayuki Saitoh, Hiroshi Shibata
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Patent number: 5506267Abstract: A compound of the invention is represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, an acyl group; R.sup.3, R.sup.4, R.sup.6 and R.sup.7 are the same or different, hydrogen or an alkyl group; R.sup.5 is hydrogen, an alkyl group or a hydroxyl group which may optionally be protected, or R.sup.4 and R.sup.5 are combined to form a chemical bond; X is a carbonyl group or a sulfonyl group; Y is an amino acid sequence consisting of 1 to 7 amino acid residues which may optionally be protected and having optionally an intervening --SO.sub.2 NH--; n is an integer of 0 to 2, or a salt thereof.Type: GrantFiled: September 8, 1994Date of Patent: April 9, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Tetsuya Aono, Koichi Yukishige, Seiichi Tanida
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Patent number: 5502225Abstract: This invention relates to perfluoroalkyl group terminated urethanes, thiourethanes and ureas of the general formula(R--X--CONH).sub.m Awhere m is 1, 2 or 3, R is R.sub.f -E and optionally R.sub.1 with the proviso that at least one R is R.sub.f -E, R.sub.f is a perfluoroalkyl group, R.sub.1 is a hydrocarbon group, E is a divalent linking group, X is --O--, --S--, --NR.sub.2 -- and R.sub.2 is H or lower alkyl and A is R.sub.f E or R.sub.1 if m is 1 and a divalent or trivalent linking group if m is 2 or 3 respectively.Compounds of this general formula are useful as solid lubricants or as additives for waxes and resins providing lubricating properties.Type: GrantFiled: November 9, 1992Date of Patent: March 26, 1996Assignee: Dynax CorporationInventors: Eduard K. Kleiner, Athanasios Karydas
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Patent number: 5414099Abstract: Chemical synthesis of amido acids, and their conversion to amido acid phenyl ester sulfates for use as bleach activators, starting from carboxylic acids and lactams.Type: GrantFiled: September 14, 1993Date of Patent: May 9, 1995Assignee: The Procter & Gamble CompanyInventors: Stephen W. Heinzman, Jeffrey S. Dupont, William C. Tettenhorst
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Patent number: 5312933Abstract: The present invention relates to a process of producing symmetrically structured difatty acid diamines by reacting mixtures of fatty acids or their esters with diamines, isolating the symmetrical difatty acid diamides from the reaction mixture by making use of their different solubilities and concentrating them by recrystallisation if necessary. The invention also provides for a process of isolating a fatty acid from a mixture of fatty acids wherein the difatty acid diamides produced in the process of the invention are saponified to yield the corresponding free fatty acid.Type: GrantFiled: February 28, 1991Date of Patent: May 17, 1994Assignee: Battelle-Institut e.V.Inventors: Rainer Frische, Jurgen Volkheimer, Klaus Wollmann, Herrmann Schomann, Judith Schneider, Alexander Ach, Renate Gross-Lannert, Bernd Best
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Patent number: 5296633Abstract: The methylated tertiary amines are selectively prepared by reacting a primary or secondary amine, or a nitrile or aminonitrile, including an aminoalcohol, etheramine, a polyamine or fatty polyamine or amidoamine, or amidopolyamine or dinitrile, with hexamethylenetetramine ("HMTA"), under hydrogen pressure at a temperature no greater than about 160.degree. C. and in the presence of a catalytically effective amount of a hydrogenation catalyst, e.g., nickel deposited onto appropriate support substrate therefor.Type: GrantFiled: December 30, 1992Date of Patent: March 22, 1994Inventor: Stephane Fouquay
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Patent number: 5252706Abstract: A peptide derivative amphiphatic compound or N-terminal salt thereof represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each represents a straight-chain or branched alkyl or acyl group having 8 to 24 carbon atoms optionally having a substituent or an unsaturated group; X represents --O--or --NH--; R.sup.3n and R.sup.3(n+1) each represents an .alpha.--amino acid side chain; n is an integer of from 0 to 5; the compound may be a racemic compound or an optically active compound when the compound has an asymmetric carbon atom; and the N-terminal salt of the compound optionally forms with an acid component; an intermediate thereof, a liposome comprising said peptide derivative amphiphatic compound and a film consisting of a monolayer or multilayers comprising the peptide derivative amphiphatic compound are disclosed.Type: GrantFiled: April 8, 1991Date of Patent: October 12, 1993Assignee: Fuji Photo Film Co., Ltd.Inventors: Hiroshi Kitaguchi, Ryoichi Nemori
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Patent number: 5216023Abstract: The compounds of the Formula (I) ##STR1## wherein R.sub.1 is a C.sub.18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOHX is 0, NH or C.sub.1-4 alkyl-N,Y is CONH.sub.2, COOH or COOMe, wherein Me is hydrogen metal, andR.sub.2 is a side chain of a any amino acid except L-GLU or L-ASP at .alpha.-position or a group of Formula--(CH.sub.2).sub.k --C.sub.6 H.sub.3 --(A).sub.2 (II),--(CH.sub.2).sub.n --X--(CH.sub.2).sub.m --X--M (III)whereink is zero or an integer of 1,n is zero or an integer of 1 to 3,m is zero or an integer of 1 to 4,A is hydroxyl or one A is hydroxyl and the other A is hydrogen.M is H or R.sub.1 --CO andX and R.sub.1 are as defined aboveand their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.Type: GrantFiled: September 12, 1990Date of Patent: June 1, 1993Assignee: Folligen Budapest Ltd.Inventors: Peter N. Literati, Gyorgy Keri, Maria Boross, Gabor Nemeth, Jeno Szilbereky, Ildiko Szilagyi
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Patent number: 5124081Abstract: Amphiphilic lipid compound having the formula: ##STR1## in which: R.sub.1 denotes a C.sub.7 -C.sub.21 alkyl or alkenyl radical,R.sub.2 denotes a saturated or unsaturated C.sub.7 -C.sub.31 hydrocarbon radical,COA denotes a group chosen from the following groups:a) COOM, M being H, Na, K, NH.sub.4 or a substituted ammonium ion derived from an amine,b) ##STR2## B being a radical derived from mono- or polyhydroxylated primary or secondary amines and R denoting a hydrogen atom or a methyl, ethyl or hydroxyethyl radical,c) ##STR3## Q denoting a substituted aminoalkyl or ammonioalkyl radical and R having the meaning indicated for b), andd) COOZ, Z representing the residue of a C.sub.3 -C.sub.7 polyol, and a process for its preparation.Cosmetic or dermopharmaceutical composition comprising the said compound and especially an aqueous dispersion of liposomes.Type: GrantFiled: June 24, 1986Date of Patent: June 23, 1992Assignee: L'OrealInventors: Guy Vanlerberghe, Alexandre Zysman, Henri Sebag