Additional Oxygen Containing (e.g., Amides Of Ricinoleic Acid, Etc.) Patents (Class 554/61)
  • Patent number: 11058659
    Abstract: This invention provides compounds, methods and compositions for the treatment of ophthalmic diseases and disorders, including retinal and choroidal disorders and related conditions. More particularly, the invention provides a method of using the provided pharmaceutical compositions for the treatment of ophthalmic diseases and disorders, including retinal and choroidal diseases, and related conditions, upon topical administration to the eye.
    Type: Grant
    Filed: February 22, 2014
    Date of Patent: July 13, 2021
    Assignee: University of Southern California
    Inventors: Nicos A. Petasis, Mark S. Humayun, Stan G. Louie
  • Patent number: 10322102
    Abstract: Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: June 18, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: Nicos A. Petasis
  • Patent number: 10072230
    Abstract: Lubricant compositions comprising an improved ashless organic friction modifier additive have been found to be capable of reducing both friction and wear. It has been found that mixtures of fatty-alkanolamides containing secondary hydroxyls on the amino alkyl substituent, such as amide mixtures prepared from bis(2-hydroxypropyl)amine and mixtures of at least two different C8-24 fatty acids, provide better oil solubility and friction reduction than alkanolamides with primary, hydroxyl functionality, such as amide mixtures prepared from di-ethanol)amine.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: September 11, 2018
    Inventor: Frank J. DeBlase
  • Patent number: 9562207
    Abstract: Lubricant compositions comprising an improved ashless organic friction modifier additive, capable of reducing both friction and wear, is provided. It has been found that mixtures of fatty-alkanolamides containing secondary hydroxyls on the amino alkyl substituent, such as amide mixtures prepared from bis(2-hydroxyporopyl)amine and mixtures of at least two different C8-24 fatty acids, provide better oil solubility and friction reduction than alkanolamides with primary hydroxyl functionality, such as amide mixtures prepared from di-ethanol)amine.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: February 7, 2017
    Assignee: Chemtura Corporation
    Inventors: Frank J. DeBlase, Faith A. Corbo
  • Publication number: 20150031878
    Abstract: The invention provides derivatives of DEA which have increased potency and hydrolysis resistance as compared to DEA, and compositions thereof, as well as methods of using these derivatives to promote neurogenesis, neurite growth and/or length, and/or promote synaptogenesis.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 29, 2015
    Inventors: Hee-Yong Kim, Juan Jose Marugan, Erika E. Englund, Samarjit Patnaik
  • Patent number: 8877972
    Abstract: A process is described for preparing alkylene oxide-adducted hydrocarbyl amides having less than 2 wt % of amine by-products by a) reacting a C4-C30 fatty acid or fatty acid lower alkyl ester with a mono- or di-hydroxy hydrocarbyl amine to form a hydrocarbyl amide; b) reacting the hydrocarbyl amide with alkylene oxide; and c) extracting the product of b) with water, acidic water, or water-containing inorganic salts or a combination thereof at a temperature from about 5° C. to 95° C. to yield an alkylene oxide-adducted hydrocarbyl amide having less than 2 wt % of amine by-products.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: November 4, 2014
    Assignee: Chevron Oronite Company LLC
    Inventors: Francois Simard, Richard E. Cherpeck
  • Publication number: 20140323457
    Abstract: The present invention relates to beta-O/S/N fatty acids and derivatives thereof, in particular the compounds of formula (I) as described and defined herein, and their pharmaceutical use, including their use in the treatment or prevention of bacterial as well as protozoan infections, in particular the treatment or prevention of infections with Gram-positive and/or Gram-negative bacteria and infectious diseases caused by and/or related to Gram-positive and/or Gram-negative bacteria. The invention further relates to the use of these compounds for preventing or eliminating biofilms.
    Type: Application
    Filed: December 6, 2012
    Publication date: October 30, 2014
    Inventors: Thomas Böttcher, Vadim Korotkov, Katrin Lorenz-Baath, Oliver Baron, Stephan Sieber
  • Publication number: 20140093513
    Abstract: The invention relates to new methods of modulating cholesterol by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) with fatty acid derivatives; and new methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid derivative. The present invention is also directed to fatty acid bioative derivatives and their use in the treatment of metabolic diseases.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 3, 2014
    Applicant: Catabasis Pharmaceuticals, Inc.
    Inventors: Jill C. Milne, Michael R. Jirousek, Chi B. Vu
  • Patent number: 8536228
    Abstract: The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12-C30 fatty acid, a nitrogenous organic base, C12-30 fatty alcohol, monoglyceride or the reaction products thereof.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: September 17, 2013
    Assignee: Microdermis Corporation
    Inventors: Griscom Bettle, III, William S. Coury
  • Patent number: 8217192
    Abstract: A problem as an object of the invention is to provide a production method of spilanthol in a large scale without using expensive reagents. The present invention provides a production method of N-isobutyl-2,6,8-decatrienamide, wherein a column chromatography purification step is not required in all processes.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: July 10, 2012
    Assignee: Takasago International Corporation
    Inventors: Shigeru Tanaka, Kenji Yagi, Hideo Ujihara, Kenya Ishida
  • Patent number: 8101785
    Abstract: The invention relates to a method for producing fatty acid alkanol amides by reacting at least one amine that contains at least one primary or secondary amino group and at least one hydroxyl group with at least one fatty acid to form an ammonium salt, said ammonium salt being subsequently converted into the alkanol amide by means of microwave radiation.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: January 24, 2012
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Matthias Krull, Roman Morschhaeuser, Peter Klug, Alexander Lerch, Christoph Kayser, Helmut Ritter, Sarah Schmitz
  • Patent number: 8049022
    Abstract: The present invention relates to fatty acid alkanolamides or polyolamides containing at least one group Y, where Y stands for CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, where a stands for an integer selected from the range from 0 to 5, or formula (I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)r— or [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, to processes for the preparation of these compounds, and to uses of these surface-active compounds.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: November 1, 2011
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
  • Publication number: 20110251294
    Abstract: Low molecular weight gelators, methods of making such gelators, organogels comprising such gelators and methods of using such organogels are described. In exemplary methods, the gelators can be used in a variety of applications including the delivery of pharmaceutical active pharmaceutical ingredients, in food, cosmetics and consumer products, and in containing the unexpected release of chemical that occur for example in spills.
    Type: Application
    Filed: March 8, 2011
    Publication date: October 13, 2011
    Applicant: Georgetown University
    Inventors: Richard G. Weiss, Ajaya Mallia Viswanatha Mallya
  • Publication number: 20110247657
    Abstract: Provided for are rinse aids that exhibit improved drying properties during automatic dish washing and thus allow cleaning methods at lower temperatures than customer reference agents. The rinse aids comprise a) at least one surfactant according to the general formula (I), where R1 is a saturated or unsaturated, branched or linear alkyl or alkenyl radical having 6 to 22 carbon atoms, R2 is hydrogen or an alkyl group having 1 to 6 carbon atoms or a group R3, and R3 is a group A-(O—CH2CHR4—)m—OR5 and R4 and R5 independently from each other are a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and A is a (CH2)n— group or a hydroxyl alkyl group having 2 to 6 carbon atoms and n is an integer from 1 to 6 and m is an integer or a fractional number from 1 to 10 and furthermore b) at least one hydrotrope, c) at least one organic hydroxycarboxylic acid and d) water.
    Type: Application
    Filed: December 11, 2009
    Publication date: October 13, 2011
    Applicant: Cognis IP Management GmbH
    Inventors: Frederic Bauer, Sabine Both, Teresa Alexandre, Melanie Nagel, Snsgar Behler, Frank Clasen
  • Publication number: 20110118347
    Abstract: A compound of the formula CH3(CH2)n—RA—(CH2)m-(CH?CH)q—(CH2)p—X wherein RA=(a); q=0 or 1; m and p are independently selected integers of at least 1; n=0 or an integer of at least 1; X is a polar group selected from —CO2RS, where Rs?H, Na, K, —NHRI, —NRIRII or RIII; —CH3OH; —CH3NH2; —CH3NHRI; or —CH3NRIRII; wherein RI, RII and RIII are independently selected from C1-C6 alkyl or an aryl group, preferably a hydrophilically substituted C1-C6 alkyl or aryl group, or RIII is an esterified glycol; and wherein 20>m+n+p+2q?2; is useful for the treatment of ringworm infection caused by Trichophyton tonsurans.
    Type: Application
    Filed: May 29, 2009
    Publication date: May 19, 2011
    Applicant: Vernolix Limited
    Inventor: Michael William Fowler
  • Publication number: 20110105773
    Abstract: A problem as an object of the invention is to provide a production method of spilanthol in a large scale without using expensive reagents. The present invention provides a production method of N-isobutyl-2,6,8-decatrienamide, wherein a column chromatography purification step is not required in all processes.
    Type: Application
    Filed: January 16, 2009
    Publication date: May 5, 2011
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Shigeru Tanaka, Kenji Yagi, Hideo Ujihara, Kenya Ishida
  • Publication number: 20110061566
    Abstract: Disclosed herein are compounds having a formula of R1—CONH—R6—CONH—R3, R1—NHCO—R6—CONH—R3, R1—CONH—R6—NHCO—R3 or R1—NHCO—R6—NHCO—R3, wherein R6 is a cyclic group having from 5 to 8 carbon atoms, wherein R1 and R3 are the same or different and comprise an alkyl group having from about 3 carbon atoms to about 200 carbon atoms, and wherein one or both of R1 and R3 include at least one hydroxyl group substituent, and ink compositions including the compounds as an ink vehicle.
    Type: Application
    Filed: November 17, 2010
    Publication date: March 17, 2011
    Applicant: XEROX CORPORATION
    Inventors: Jeffrey H. BANNING, Stephan V. Drappel, Michael B. Meinhardt, Randall R. Bridgeman, Alex J. Kugel
  • Publication number: 20110015416
    Abstract: A method for mixing fluids that can control mixing characteristics of fluids, a method for producing particulates that can provide desired particulates, and particulates produced thereby are provided. According to an embodiment of the present invention, in a method for mixing at least two kinds of fluids in a microreactor, a first fluid is supplied to a mixing zone through a divided supply passage, and a second fluid is supplied to the mixing zone through a supply passage. A total value of dynamic pressures of the first and second fluids is controlled to mix the first and second fluids in the mixing zone. Then, the mixed fluids are flowed into a micro passage.
    Type: Application
    Filed: July 12, 2010
    Publication date: January 20, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Tomohide UEYAMA, Hideharu NAGASAWA
  • Patent number: 7851642
    Abstract: Disclosed are ?-amino-?-hydroxy-?-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: December 14, 2010
    Assignee: Novartis AG
    Inventors: Daniel Kaspar Baeschlin, Juergen Klaus Maibaum, Holger Sellner
  • Patent number: 7790924
    Abstract: A process is described for preparing alkylene oxide-adducted hydrocarbyl amides having less than 2 wt % of amine by-products by a) reacting a C4-C30 fatty acid or fatty acid lower alkyl ester with a mono- or di-hydroxy hydrocarbyl amine to form a hydrocarbyl amide; b) reacting the hydrocarbyl amide with alkylene oxide; and c) extracting the product of b) with water, acidic water, or water-containing inorganic salts or a combination thereof at a temperature from about 5° C. to 95° C. to yield an alkylene oxide-adducted hydrocarbyl amide having less than 2 wt % of amine by-products.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: September 7, 2010
    Assignee: Chevron Oronite Company LLC
    Inventors: Francois Simard, Richard E. Cherpeck
  • Patent number: 7683193
    Abstract: Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: March 23, 2010
    Assignee: University of Southern California
    Inventor: Nicos A. Petasis
  • Publication number: 20100055168
    Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 4, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, Aparna V. Sarthy, Yu Shen, Lu Tian, Carol K. Wada, Xiaobin Zhao
  • Publication number: 20100055169
    Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 4, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, Aparna V. Sarthy, Yu Shen, Lu Tian, Carol K. Wada, Xiaobin Zhao
  • Publication number: 20100010244
    Abstract: The invention relates to a method for producing fatty acid alkanol amides by reacting at least one amine that contains at least one primary or secondary amino group and at least one hydroxyl group with at least one fatty acid to form an ammonium salt, said ammonium salt being subsequently converted into the alkanol amide by means of microwave radiation.
    Type: Application
    Filed: October 5, 2007
    Publication date: January 14, 2010
    Applicant: Clariant Finance (BVI)Limited
    Inventors: Matthias Krull, Roman Morschhaeuser, Peter Klug, Alexander Lerch, Christoph Kayser, Helmut Ritter, Sarah Schmitz
  • Publication number: 20090312432
    Abstract: The present invention relates to fatty acid alkanolamides or polyolamides containing at least one group Y, where Y stands for CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, where a stands for an integer selected from the range from 0 to 5, or formula (I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)r— or (CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, to processes for the preparation of these compounds, and to uses of these surface-active compounds.
    Type: Application
    Filed: July 2, 2007
    Publication date: December 17, 2009
    Inventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
  • Publication number: 20090285881
    Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
    Type: Application
    Filed: April 16, 2009
    Publication date: November 19, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, Carol K. Wada, Lu Tian, Xiaobin Zhao
  • Patent number: 7595341
    Abstract: The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ?-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: September 29, 2009
    Assignees: Resolvyx Pharmacuticals, Inc., The Brigham and Women's Hospital
    Inventors: Daniel W. Goodman, Michael R. Hanley, Stuart L. Bursten, Charles N. Serhan
  • Patent number: 7589220
    Abstract: Disclosed are compounds that are anandamide transport inhibitors and their pharmacological use.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: September 15, 2009
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Andreas Goutopoulos, Chen Li
  • Publication number: 20090223409
    Abstract: Disclosed herein are amide compounds suitable for use in ink compositions, and methods of making the amide compounds disclosed herein.
    Type: Application
    Filed: March 7, 2008
    Publication date: September 10, 2009
    Applicant: XEROX CORPORATION
    Inventors: Jeffrey H. BANNING, Stephan V. DRAPPEL, Michael B. MEINHARDT, Randall R. BRIDGEMAN, Alex J. KUGEL
  • Patent number: 7582306
    Abstract: The present invention relates to a pseudoceramide represented by the following formula (I) and a cosmetic composition comprising the same: wherein Z represents —OH and Y represents —OH, ?with the proviso that X is Z represents —OH and X represents —OH, with the proviso that Y is Y represents —OH and X represents —OH, with the proviso that Z is R represents a linear or branched, saturated or unsaturated aliphatic hydrocarbon group; and when substituted, R has one or more —OH groups.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: September 1, 2009
    Assignee: Coreana Cosmetics Co., Ltd.
    Inventors: Jung-No Lee, Kang-Tae Lee, Jee-Hean Jeong, Byong-Kee Jo
  • Patent number: 7582782
    Abstract: Disclosed are ?-amino-?-hydroxy-?-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
    Type: Grant
    Filed: November 25, 2004
    Date of Patent: September 1, 2009
    Assignee: Novartis AG
    Inventors: Daniel K Baeschlin, Juergen K Maibaum, Holger Sellner
  • Patent number: 7378444
    Abstract: The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ?-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: May 27, 2008
    Assignees: Brigham and Women's Hospital, Inc., Resolvyx Pharmaceuticals, Inc.
    Inventors: Daniel W. Goodman, Michael R. Hanley, Stuart L. Bursten, Charles N. Serhan
  • Patent number: 7253295
    Abstract: Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin compound to facilitate chloride ion transportation.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: August 7, 2007
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, John Cuppoletti
  • Patent number: 7161016
    Abstract: Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications for relief of pain caused by cancer and nausea caused by chemotherapy, as well as for peripheral pain. The compounds may also be useful as oral and topical contraceptives, in suppression of the immune system, enhancement of appetite and in treatment of psychomotor disorders, multiple sclerosis and hypertension.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: January 9, 2007
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Atmaram Khanolkar, Andreas Goutopoulos
  • Patent number: 6835846
    Abstract: The present invention provides an aliphatic compound represented by the following formula (I) or pharmacologically acceptable salts thereof: where n denotes an integer of 1 to 11, and 1 denotes an integer of 1 to 16, the aliphatic compound being an optical isomer of the (2R,3S,2′S) configuration when the 8-position thereof is a double bond, or an optical isomer of the (2S,3R,2′RS) configuration when the 8-position is a single bond; methods for producing the compound or pharmacologically acceptable salts thereof; and uses of the compound in the treatment of cardiovascular diseases (e.g. arteriosclerosis, cardiac diseases), cancer, rheumatism, diabetic retinopathy, and respiratory diseases.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: December 28, 2004
    Assignee: Maruha Corporation
    Inventors: Tadakazu Tamai, Masazumi Nishikawa, Kenji Mori
  • Patent number: 6803385
    Abstract: Hydroxyeicosatetraenoic acid esters and methods of their use in treating dry eye disorders are disclosed.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: October 12, 2004
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow
  • Patent number: 6800770
    Abstract: The invention compounds and methods for the treatment of motor disorders. In particular, the invention provides eicosanoid analogs which are effective in ameliorating motor disorders such as spasticity caused by multiple sclerosis (MS).
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: October 5, 2004
    Assignee: Virginia Commonwealth University
    Inventors: Billy Martin, Raj K. Razdan, Anu Mahadevan, David Baker
  • Publication number: 20040122105
    Abstract: The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12-C30 fatty acid, a nitrogenous organic base, C12-30 fatty alcohol, monoglyceride or the reaction products thereof.
    Type: Application
    Filed: September 22, 2003
    Publication date: June 24, 2004
    Inventors: Griscom Bettle, William S. Coury
  • Publication number: 20040048894
    Abstract: Compounds which mimic the chemical and/or biological activity of discodermolide are provided.
    Type: Application
    Filed: June 2, 2003
    Publication date: March 11, 2004
    Inventors: Amos B Smith, Thomas Beauchamp, Matthew J Lamarche, Paul V Rucker
  • Publication number: 20040044050
    Abstract: The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 &ohgr;-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.
    Type: Application
    Filed: June 13, 2003
    Publication date: March 4, 2004
    Inventors: Daniel W. Goodman, Michael R. Hanley, Stuart L. Bursten
  • Patent number: 6693208
    Abstract: Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gscheidner, Andrea Leone-Bay, Eric Wang, John J. Freeman, Doris C. O'Toole, Lynn Shields
  • Publication number: 20040014816
    Abstract: The present invention provides an aliphatic compound represented by the following formula (I) or pharmacologically acceptable salts thereof: 1
    Type: Application
    Filed: April 11, 2003
    Publication date: January 22, 2004
    Inventors: Tadakazu Tamai, Masazumi Nishikawa, Kenji Mori
  • Publication number: 20040002541
    Abstract: The invention compounds and methods for the treatment of motor disorders. In particular, the invention provides eicosanoid analogs which are effective in ameliorating motor disorders such as spasticity caused by multiple sclerosis (MS).
    Type: Application
    Filed: January 17, 2003
    Publication date: January 1, 2004
    Inventors: Billy Martin, Raj K. Razdan, Anu Mahadevan, David Baker
  • Publication number: 20030236423
    Abstract: The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides trihydroxy polyunsaturated eicosanoids and their use in pharmaceutical compositions.
    Type: Application
    Filed: April 1, 2003
    Publication date: December 25, 2003
    Inventor: Nicos A. Petasis
  • Publication number: 20030235612
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: February 24, 2003
    Publication date: December 25, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, David Gschneidner, Koc-Kan Ho
  • Publication number: 20030216589
    Abstract: Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
    Type: Application
    Filed: July 15, 2002
    Publication date: November 20, 2003
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, John J. Freeman, Doris C. O'Toole, Lynn Shields
  • Patent number: 6552084
    Abstract: Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: April 22, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow
  • Patent number: 6524353
    Abstract: A fuel additive composition composed of the reaction product of (a) mixed fatty acid esters; (b) a mono or di-(hydroxy alkyl amine) or mixtures thereof; and (c) a low temperature property enhancing effective amount of a low molecular weight ester; wherein the reaction mixture has a molar ratio of amine to total ester content in the range from 10.0 to 1.0. The fuel additive exhibits detergent and friction reducing properties when added to a fuel thereto and further exhibits good low temperature stability properties. Methods for making the inventive composition and fuel compositions containing the additive are also disclosed.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: February 25, 2003
    Assignee: Texaco Development Corporation
    Inventors: Thomas F. de Rosa, Benjamin J. Kaufman, Frank J. DeBlase, James R. Ketcham, Michael G. Rawdon, Max R. Cesar
  • Patent number: 6521662
    Abstract: A ceramide-like compound having properties of the natural ceramides are represented by the following formula (I), and a method for producing the same , and a cosmetic composition containing the same as an active ingredient:
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: February 18, 2003
    Assignee: Pacific Corporation
    Inventors: Ho Sik Rho, Duck Hee Kim, Kil Joong Kim, Jae Won You, Hak Hee Kang, Ok Sub Lee, Jong Ho Park, Su Sun An, Eui Dong Son
  • Publication number: 20020143196
    Abstract: Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Inhibition of histone deacetylase can lead to the histone deacetylase-mediated transcriptional repression of tumor suppressor genes. For example, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, such as hematopoiesis, and genetic related metabolic disorders, such as, cystic fibrosis and adrenoleukodystrophy.
    Type: Application
    Filed: March 27, 2001
    Publication date: October 3, 2002
    Inventors: Hsuan-Yin Lan-Hargest, Robert J. Kaufman, Norbert L. Wiech