Abstract: Chemically-modified fatty acids prepared by reacting epoxidized fatty acids, their esters or triglyceride oils with borate compounds. The fatty acid derivatives produced are of the formula: wherein R is an H, branched or straight chain alkyl or alkenyl group, aromatic-containing group, glycerol, or glyceride, R? is a C3 to C29 aliphatic chain comprising one or more of the derivatized methylene groups of the formula: wherein m, n, and p are independently selected from 0 and 1; X is selected from O, NH, C(O)O, S, —C?N, —N?C?O, —N?C; and a borate of the formula: and R1 is selected from aryl, and straight, branched, cyclic or heterocyclic hydrocarbons or substituted hydrocarbons. These fatty acid derivatives have utility as antiwear/antifriction additives for industrial oils, fuels, and automotive applications.

Abstract: The invention relates to the use of a conjugated seed oil modified with an activated vinyl monomer via a Deils-Alder reaction to generate a modified reactive diluent used to enhance the physical properties of coating systems. In one embodiment, a reactive diluent containing tung oil modified by the addition of an acrylate monomer is mixed with an auto-oxidative alkyd, a metal drier package, and a wetting agent to achieve cross-linked films exhibiting improved tensile strength, tensile modulus, cross-link density, and glass transition temperature, among other physical parameters.

Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The silane-modified oil is substantially stripped of substantially stripped of reagents prior to formulating into the consumer products, such that the silane-modified oil comprises less than about 10%, preferably less than about 5%, preferably less than about 1%, preferably less than about 0.1%, by weight of said silane-modified oil, of residual reagent comprising silicon.

Abstract: The present invention is aimed at a series of novel glycerin polyesters that provide desired aesthetics and structure in cosmetic formulation. These glycerin polymers are synthesized by polycondensation polymerization, in the presence of a monofunctional monomer or terminal group. By carefully choosing the groups the properties can be dramatically altered. The mono-functional alcohols, being only able to react in one position, can only be located on the polymer chain ends. This provides very unique polymer structure and morphology. These regiospecific polyesters will have very unique physical properties and have a wide variety of solubilities. Furthermore, by the incorporation of a co-monomer will produce a copolymer with drastically different solubilities and aesthetics.

Abstract: The present invention is directed to a series of functionalized glycerin based polymers that have been designed to have very specific substitution patterns, herein referred to as regio-specific substitution (RSS). We have surprisingly found that by linking triglycerides into polymer backbones and controlling the location of the different alkyl groups along that backbone, the performance and structure can be fine tuned. The properties of these polymers can be controlled and tuned by judicial control of the polymerization conditions, specifically by employing the use of mono-functional monomers. This polymer will has “compartments” of solid and liquid pendant group domains if the proper pendant groups are chosen. This unique multi-dimensional, high definition polymer will have very unique physical properties, including unique shear and flow behaviors. These polymers will provide outstanding and unique skin feels when used in cosmetic applications.

Abstract: The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.

Abstract: The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.

Abstract: The present invention is directed to a series of silicone containing polymeric glyceryl esters that have two different molecular weight ester chains, one solid and one liquid, which when combined into a single molecule make a polymer that is solid, but has very unique flow properties. These materials find applications as additives to formulations in personal care products where there is a desire to have a structured film (provided by the solid fatty group) and flow properties, (provided by the liquid fatty group). These compounds by virtue of their unique structure provide outstanding skin feel.

Abstract: The present invention is directed toward a series of polyglycerol silicone polyesters with tunable ascetics and performance in cosmetic formulation. These novel polyglycerol silicone polyesters are designed to be high definition polymers. High Definition Polymers is meant that the polymer contains a variety of groups containing different chemical and physical properties that can be controlled by the polymerization process. High definition polymers are polymers are synthesized to have each portion of the polymer to achieve a desired aesthetics. These high definition polymers physical properties can be tuned quickly and easily but the polymerization conditions. The physical properties of the current invention can be tuned rapidly by controlling the ratio of fatty groups, as well as the cross-linker used. The resulting polyglycerol silicone polyesters have outstanding aesthetics, unique solubility and physical properties.

Abstract: The invention relates to novel resolvin compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel resolvin compounds of the invention.

Abstract: A compound includes a boron atom attached to at least one C8-C26 fatty acid residue having at least one C?C moiety. Such compounds are polymerizable through the at least one C?C moiety. Polymers thus formed exhibit anti-fouling properties when used as coatings.

Abstract: The present invention is directed to a series of functionalized glycerin based polymers that have been designed to have very specific substitution patterns, herein referred to as regio-specific substitution (RSS). The properties of these polymers can be controlled and tuned by judicial control of the polymerization conditions, specifically by employing the use of mono-functional monomers. This polymer will has “compartments” of solid and liquid pendant group domains if the proper pendant groups are chosen. This unique multi-dimensional, high definition polymer will have very unique physical properties, including unique shear and flow behaviors. These polymers will provide outstanding and unique skin feels when used in cosmetic applications.

Abstract: A dioxaborinane compound, or salt thereof, where boron has two oxy substituents, each independently substituted with H, alkyl, alkenyl, aryl, —C(O)R3, —C(O)OR3, —C(O)NHR3, or the two oxy substituents, together with the oxygen atoms to which they are bonded, join to form a 5- or 6-membered ring; and R3 is H, alkyl, alkenyl, or aryl, where the alkyl and alkenyl are optionally interrupted with one or more oxygen or sulfur atoms; and where boron also has the substituent -L-X1-PG1; where L may be absent, or alkylenyl, alkenylenyl, or arylene, where the alkylenyl and alkenylenyl are optionally interrupted with one or more oxygen or sulfur atoms; X1 is absent, or is amino, oxo, thio, or phosphino; and PG1 is a polymerizable group. The dioxaborinane compound can be used as a wood preservative.

Abstract: The present invention is directed to a series of silicone containing polymeric glyceryl esters that have two different molecular weight ester chains, one solid and one liquid, which when combined into a single molecule make a polymer that is solid, but has very unique flow properties. These materials find applications as additives to formulations in personal care products where there is a desire to have a structured film (provided by the solid fatty group) and flow properties, (provided by the liquid fatty group). These compounds by virtue of their unique structure provide outstanding skin feel.

Abstract: The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.

Abstract: A dioxaborinane compound, or salt thereof, where boron has two oxy substituents, each independently substituted with H, alkyl, alkenyl, aryl, —C(O)R3, —C(O)OR3, —C(O)NHR3, or the two oxy substituents, together with the oxygen atoms to which they are bonded, join to form a 5- or 6-membered ring; and R3 is H, alkyl, alkenyl, or aryl, where the alkyl and alkenyl are optionally interrupted with one or more oxygen or sulfur atoms; and where boron also has the substituent -L-X1—PG1; where L may be absent, or alkylenyl, alkenylenyl, or arylene, where the alkylenyl and alkenylenyl are optionally interrupted with one or more oxygen or sulfur atoms; X1 is absent, or is amino, oxo, thio, or phosphino; and PG1 is a polymerizable group. The dioxaborinane compound can be used as a wood preservative.

Abstract: The present invention is directed to a series of silicone containingpolymeric glyceryl esters that have two different molecular weight ester chains, one solid and one liquid, which when combined into a single molecule make a polymer that is solid, but has very unique flow properties. These materials find applications as additives to formulations in personal care products where there is a desire to have a structured film (provided by the solid fatty group) and flow properties, (provided by the liquid fatty group). These compounds by virtue of their unique structure provide outstanding skin feel.

Abstract: The invention concerns polysiloxane compounds as W/O-emulsifiers, in textile softeners, antifoams, foam stabilizers and agriculture chemicals, in particular as W/O-emulsifiers for cosmetic uses.

Abstract: The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.

Abstract: The invention relates to novel resolvin compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel resolvin compounds of the invention.

Abstract: Chemically-modified fatty acids prepared by reacting epoxidized fatty acids, their esters or triglyceride oils with borate compounds. The fatty acid derivatives produced are of the formula: wherein R is an H, branched or straight chain alkyl or alkenyl group, aromatic-containing group, glycerol, or glyceride, R? is a C3 to C29 aliphatic chain comprising one or more of the derivatized methylene groups of the formula: wherein m, n, and p are independently selected from 0 and 1; X is selected from O, NH, C(O)O, S, —C?N, —N?C?O, —N?C; and a borate of the formula: and R1 is selected from aryl, and straight, branched, cyclic or heterocyclic hydrocarbons or substituted hydrocarbons. These fatty acid derivatives have utility as antiwear/antifriction additives for industrial oils, fuels, and automotive applications.

Abstract: A moisture-curable, silane-modified oil is disclosed. The silane-modified oil includes an unsaturated oil having at least one unsaturated aliphatic hydrocarbon chain per molecule of the unsaturated oil, and at least one hydrolysable silyl group grafted to the unsaturated aliphatic hydrocarbon chain. The silane-modified oil has a degree of unsaturation that is substantially similar that of the unsaturated oil. A process for forming the moisture-curable, silane-modified oil according to the disclosure includes reacting the unsaturated oil with an unsaturated hydrolysable silane in the presence of a free radical initiator. Also disclosed is a cured silane-modified oil which includes the reaction product of the silane-modified oil and water. Compositions according to the disclosure have relatively low viscosities (facilitating their application to a substrate) and have relatively high levels of silane grafting (resulting in non-leaching cured compositions with a high gel content).

Abstract: The present invention discloses boronic acids and esters of phospholipid ether analogs and methods for their synthesis and use. The boronic acids and esters of phospholipid ether analogs described herein can be used in treating cancer and in particular can be used in conjunction with radiation therapy, such as external beam radiation therapy and neutron capture therapy to specifically target and kill cancer cells.

Abstract: The invention relates to the use of a conjugated seed oil modified with an activated vinyl monomer via a Deils-Alder reaction to generate a modified reactive diluent used to enhance the physical properties of coating systems. In one embodiment, a reactive diluent containing tung oil modified by the addition of an acrylate monomer is mixed with an auto-oxidative alkyd, a metal drier package, and a wetting agent to achieve cross-linked films exhibiting improved tensile strength, tensile modulus, cross-link density, and glass transition temperature, among other physical parameters.

Abstract: A moisture-curable, silane-modified oil is disclosed. The silane-modified oil includes an unsaturated oil having at least one unsaturated aliphatic hydrocarbon chain per molecule of the unsaturated oil, and at least one hydrolysable silyl group grafted to the unsaturated aliphatic hydrocarbon chain. The silane-modified oil has a degree of unsaturation that is substantially similar that of the unsaturated oil. A process for forming the moisture-curable, silane-modified oil according to the disclosure includes reacting the unsaturated oil with an unsaturated hydrolysable silane in the presence of a free radical initiator. Also disclosed is a cured silane-modified oil which includes the reaction product of the silane-modified oil and water. Compositions according to the disclosure have relatively low viscosities (facilitating their application to a substrate) and have relatively high levels of silane grafting (resulting in non-leaching cured compositions with a high gel content).

Abstract: The present invention discloses boronic acids and esters of phospholipid ether analogs and methods for their synthesis and use. The boronic acids and esters of phospholipid ether analogs described herein can be used in treating cancer and in particular can be used in conjunction with radiation therapy, such as external beam radiation therapy and neutron capture therapy to specifically target and kill cancer cells.

Abstract: The present invention is drawn to a process for providing emolliency to the skin using a series so called “silicone spider esters”. These esters are derived from poly-hydroxy functional compounds sequentially reacted with ethylene oxide or propylene oxide, followed by the reaction of the alkoxylate with fatty acid. The resulting products are called silicone spider esters because they resemble the spider, wherein appendages are alkoxylated esters. The restrictions this orientation imposes on rotation allows for the preparation of polar esters that have little or no water solubility, and provide both moisturization to the skin and emolliency by reducing transepidermal water loss.

Abstract: A method for the preparation of a prostaglandin F analogue presented by the following formula (I): is disclosed, wherein R1, G1, and are as defined in the specification. A novel intermediate compound for the preparation of a prostaglandin F analogue is also disclosed.

Abstract: A carnuba silicone wax which does not contain free silicone oil. This wax is obtained by reacting a silicone compound having a substituent with reactivity to the hydroxyl group in natural carnuba wax, with this hydroxyl group. A carboxyl group may be introduced into the molecule by reacting this hydroxyl group with a cyclic acid anhydride, and a silicone compound having a group which can react directly with this carboxyl group is made to react. Alternatively, a hydrogen silicone may be hydrosilylated by a double bond introduced by reacting an epoxy compound having a double bond with this carboxyl group.

Abstract: The invention relates to a series of novel silicone fatty esters, specifically dimethicone copolyol erucate esters. This class of compounds provides has a unique combination of properties including clarity and liquidity and oxidative stability and water solubility of the silicone ester per se, and the ability to provide outstanding softening and wet comb lubrication, as well as actually strengthening the hair. These properties are highly desirable in cosmetic products. The compounds of the present invention are prepared by reacting the hydroxyl group in a silicone polymer with erucic acid, or an oil high in erucic acid like crambe oil. The compounds of the present invention have more than 40% by weight of erucic groups in the molecule. The concentration of this key component has been found to be critical to performance.

Abstract: A method of preparing unsaturated hydroxy fatty acids and esters thereof corresponding to general formula (Id): 1

Abstract: The present invention relates to cranberry seed oil derivatives derived by the reaction of dimethicone copolyol and cold pressed cranberry seed oil. The choice of cold pressed cranberry seed oil as a raw material in the preparation of the compounds of the present invention is critical, since it has been found that the cold pressed cranberry seed oil contains antioxidants, antimicrobial compounds and which when reacted with a water soluble or water dispersible silicone result in products that deliver said actives to the skin and hair, resulting in protection of the skin and hair from environmental factors such as acid rain, ozone attack and UV degradation.

Abstract: A composition of selenium monobromide-oil reaction product including a reaction product of selenium momobromide-in-oil prepared from eleostearic acid and selenium monobromide, which contains at least about 0.1 percent of selenium monobromide and exhibits ultraviolet absorption maxima typical of conjugated trienes and conjugated dienes and pharmnaceutical composition thereof for administration to a subject in a therapeutically effective amount to treat neoplastic conditions such as cancer. Methods of making such compositions are also encompassed, as are methods for treating neoplastic conditions by administering to a subject an effective amount of a selenium monobromide-oil reaction product with epichlorohydrin.

Abstract: A carnuba silicone wax which does not contain free silicone oil. This wax is obtained by reacting a silicone compound having a substituent with reactivity to the hydroxyl group in natural carnuba wax, with this hydroxyl group. A carboxyl group may be introduced into the molecule by reacting this hydroxyl group with a cyclic acid anhydride, and a silicone compound having a group which can react directly with this carboxyl group is made to react. Alternatively, a hydrogen silicone may be hydrosilylated by a double bond introduced by reacting an epoxy compound having a double bond with this carboxyl group.

Abstract: The present invention relates to a series of novel silicone alkoxylated esters which have terminal carboxyl groups that form salt complexes with certain amid containing cationic compounds to form very mild conditioning products suited for personal care applications like shampoos, body wash, hand wash and bath products.

Abstract: The invention relates to a series of novel propoxylated silicone rosin esters. This class of compounds provides unique solubility in organic solvents like iso-paraffin, and despite its lack of water solubility, provides an ability to couple water into anhydrous systems like lipsticks, minimizing the incompatibility that causes syneresis.

Abstract: The present invention relates to novel fatty acid analogous of the general forumla I: CH3—[CH2]m—[xi—CH2]n—COOR, as defined in the specification, which can be used for the treatment and/or prevention of obesity, fatty liver and hypertension. Further, the invention relates to a nutritional composition comprising such fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal. The invention also relates to a method for improving the quality of product such as meat, milk and eggs.

Abstract: The present invention relates to novel fatty acid analogues of the general formula (I): CH3—[CH2]m—[xi—CH2]n—COOR, as defined in the specification, which can be used for the treatment and/or prevention of diabetes. Further, the invention relates to a nutritional composition comprising such fatty acid analogues.

Abstract: Process for the stereoselective reduction of chiral &agr;- or &bgr;-keto esters which have a chiral center in the &ggr; position in an inert solvent at temperatures from −80 to +50° C. using a reductant obtained by reaction of NaBH4 and (D)- or (L)-tartaric acid, to give the corresponding diastereomeric hydroxy compounds in each case.

Abstract: This invention relates to composition of matter of certain euganol functionalized silicone polymers useful to make substantive antimicrobial agents. These compounds allow for the topical delivery of euganol to the skin surface, where it has a variety of desirable effects.

Abstract: Phospholipid compositions that may be represented by the following general formula: wherein: A is selected from H, M, and R—Y—; A1 is selected from H, OH, OM and R—Y—O—; x is 0 or an integer from 1 to 5; M is a cation; Y is alkylene or substitued alkylene; and R is a mixture of quaternized amidoamine and/or amine moieties selected from the group consisting of: a) a quaternized organosilicone amidoamine moiety of the formula: b) a quaternized organosilicone tertiary amine moiety of the formula:  or a mixture of the quaternized organosilicone amidoamine moiety “a” and/or quaternized tertiary amine moiety “b” above and the moieties: c) a quaternized organic amidoamine moiety of the formula: d) an organic quaternized tertiary amine moiety of the formula: with the proviso that wherein R is a mixture of organosilicone amine and organic amine moieties, at least

Abstract: New compositions of matter are organofunctional cocyclic siloxanes of the formula ##STR1## where R1 to R3 are alkyl groups of 1-6 carbon atoms; a and b have a value of 1-10; and R4 is an aminoalkyl group or a carboxyalkyl group. Some representative R4 groups are --CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 NH.sub.2, --CH.sub.2 CH(CH.sub.3)CH.sub.2 NHCH.sub.2 CH.sub.2 NH.sub.2, and --(CH.sub.2).sub.10 COOH.

Abstract: A method of manufacturing acyloxysilane compounds having functional groups bonded to a silicon atom via Si--C bonds comprising reacting in a hydrosilation reaction an unsaturated compound (a) selected from the group consisting of (i) styrene or styrene derivative, (ii) vinylsilane compound, (iii) siloxane compound having a vinyl group bonded directly to a silicon atom, (iv) epoxy-functional olefin, (v) diene compound, (vi) allyl compound described by formula CH.sub.2 .dbd.CHCH.sub.2 X, where X is a halogen atom, an alkoxy group, or an acyloxy group, (vii) olefin compound having a terminal vinyl group, and (viii) acetylene-type compound with a silicon compound (b) that contains hydrogen atom bonded to the silicon atom and acyloxy group in the presence of a platinum catalyst.

Abstract: The present invention relates to certain reconstituted wax esters, prepared by the reaction of a silicone polymer and a natural high molecular wax ester selected from the group consisting of beeswax, candelillia, and carnauba wax. These materials are useful in preparation of cosmetic products where their ability to couple organic silicone and other components into a uniform mass is unsurpassed. One major area for the use of these materials is in lipsticks. In addition they are useful in antiperspirants and other formulations which contain both oils and silicones.

Abstract: Silicon-containing peroxyester compounds, for example, represented by the following formula: ##STR1## useful as a polymerization initiator, which compounds can produce vinyl chloride polymers having a high quality in a high yield and in a short reaction time.

Abstract: A flame retardant organic silicon and phosphorus containing compound is produced by reacting a silicon halides compound with an organic phosphorus compound to produce an organic silicon and phosphorus halides compound which is then reacted with an organic compound to produce an organic silicon and phosphorus containing compound. This organic silicon and phosphorus containing compound is incorporated in an otherwise more flammable organic material under reaction conditions and in an amount sufficient to reduce the combustibility of the otherwise more flammable organic material. The organic silicon and phosphorus containing compound may also be utilized as coating agents, adhesives, surfactants, insecticides, hydraulic fluid and other uses.

Abstract: A mixture of silicon and phosphorus are heated and reacted with halide to produce silicon tetrahalides, silicon-phosphorus halide and phosphorus trihalides compositions. These compositions are reacted with any suitable organic, inorganic-organic and/or inorganic compound to produce novel organic silicon-phosphorus containing compositions. These compositions may be utilized as flame retardants, coating agents, adhesives and many other uses.

Abstract: A mixture of silicon and phosphorus are heated and reacted with halide to produce silicon tetrahalides, silicon-phosphorus halide and phosphorus trihalides compositions. These compositions are reacted with any suitable organic, inorganic-organic and/or inorganic compound to produce novel organic silicon-phosphorus containing compositions. These compositions may be utilized as flame retardants, coating agents, adhesives and many other uses.

Abstract: The invention discloses novel silicone compounds which contain an amino group on the molecule, and an ester linkage between the two. Compounds of the invention are made by reacting (a) a carboxy silicone, and (b) a hydroxy containing tertiary amine. Compounds may also contain a polyoxyalkylene group. Compounds of the invention by virtue of (i) the silicone group, (ii) the ester group and (iii) the amino group are extremely efficient softeners.

Abstract: The invention is directed to a process for the transesterification of carboxylic acid esters, in which process a catalyst is used which is substantially insoluble in the reaction mixture under reaction conditions, said catalyst comprising at least one silicate of the Group IVB elements of the Periodic Table as the active component.