Abstract: The invention relates to a continuous method for the production of Grignard adducts, in which the magnesium chips are activated mechanically in situ. Furthermore, the invention relates to a device for implementation of the method according to the invention.
Type:
Grant
Filed:
March 29, 2017
Date of Patent:
June 6, 2023
Assignee:
Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V.
Inventors:
Gabriele Menges-Flanagan, Christian Hofmann
Abstract: Described is a process for the preparation of hydrocarbyl metal halides, such as alkyl tin chlorides, in which a reaction between the metal in its metallic state and a hydrocarbyl halide is catalyzed by a dihydrocarbyl sulfoxide or a dihydrocarbyl formamide in the presence of a hydrocarbyl metal halide and wherein the pressure of the reaction vessel is varied during the reaction.
Abstract: Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
Type:
Grant
Filed:
November 6, 1997
Date of Patent:
July 9, 2002
Assignee:
University of Pittsburgh
Inventors:
William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
Type:
Grant
Filed:
April 18, 1997
Date of Patent:
January 2, 2001
Assignee:
University of Pittsburgh
Inventors:
William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
Abstract: A process is provided for the production of metalorganic compounds by reacting a Grignard reagent with a Group II, Group III or Group V metal halide in a tertiary alkyl amine solvent to form a metalorganic adduct, isolating the adduct and dissociating the adduct to leave the metalorganic compound.
Type:
Grant
Filed:
July 14, 1997
Date of Patent:
March 23, 1999
Assignee:
Secretary of State For Defence Acting Through His Defence Evaluation & Research Agency
Inventors:
Anthony Copeland Jones, Simon Andrew Rushworth, Trevor Martin, Timothy John Whittaker, Richard William Freer