Nitrogen Containing Patents (Class 556/107)
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Publication number: 20150056114Abstract: Disclosed are a compound including an oxalate, a carbon dioxide absorbent including the same, a method of preparing the carbon dioxide absorbent and a method of removing carbon dioxide, which may overcome issues of high recycling energy and low absorptivity of a conventional carbon dioxide absorbent to considerably reduce recycling energy and absorb a greater amount of carbon dioxide per unit absorbent, so that a size of a carbon dioxide absorption tower may be reduced and a less amount of recycling energy may be used, contributing to a substantial decrease in device manufacture costs and management costs.Type: ApplicationFiled: December 24, 2013Publication date: February 26, 2015Applicant: KOREA INSTITUTE OF ENERGY RESEARCHInventors: Soon Kwan JEONG, Yeo II YOON, Sung Chan NAM, Soo Hyun CHOI, Sung Ho YOON, Nam Seok KIM, Bon Sik JOO
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Publication number: 20150011523Abstract: The invention relates to complexes of germanium with amino acids and carboxylic acids of the general formula Ge[OH]a[AA]b[CA]c (I), where AA is an amino acid, CA is a carboxylic acid, a=0-3, b=1-3, c=0-3, and 1<b+c?4, wherein AA and AC in the complex can be identical or different, and to a method for preparing same. The method preparing an aqueous suspension of germanium dioxide, adding an amino acid and a carboxylic acid to the aqueous suspension of germanium oxide produced, heating the mixture produced with agitation at a temperature of 40-100° C. for 2-14 hours with subsequent filtering, removal of the water and production of a complex in solid form. The method makes it possible to prepare stable complexes with a controllable composition and a control fable ratio of germanium to amino acid and carboxylic acid which are stable in solid form and can be used in medicine.Type: ApplicationFiled: November 9, 2012Publication date: January 8, 2015Inventors: Alexandr Dmitrievich Isaev, Tamaz Omarovich Manasherov, Igor Valerievich Ambrosov, Svetlana Konstantinovna Matelo
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Patent number: 8076499Abstract: A method for preparing a precursor of radioactive 3-iodobenzylguanidine- N,N?-bis(tert-butyloxycarbonyl)-3-(tri-n-butyltin)benzylguanidine) (MSnBG) is revealed. The method includes following steps. Firstly, obtain 3-iodobenzylguanidine bicarbonate by an addition reaction between 3-iodobenzylamine hydrochloride and cyanamide. Use di-tert-butyl dicarbonate as a protecting agent for NH group and convert 3-iodobenzylguanidine bicarbonate into N,N?-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine. At last, under catalysis of bis(triphenylphosphine) palladium dichloride, obtain a final product MSnBG by a substitution reaction between N,N?-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine and bis(tri-n-butyltin). MSnBG is used in no-carrier-added synthesis of [*l]MIBG.Type: GrantFiled: August 13, 2009Date of Patent: December 13, 2011Assignee: Atomic Energy Council-Institute of Nuclear Energy ResearchInventors: Show-Wen Liu, Cheng-Hsien Lin, Tsyh-Lang Lin, Cheng-Fang Hsu
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Patent number: 7595415Abstract: To provide ?-substituted vinyltin useful for the search for function-developing substances such as pharmaceuticals/agrichemicals and functional materials and for the construction of a compound library. An ?-substituted vinyltin compound represented by the formula (1), a tautomer or salt of the compound or a solvate thereof: R2CH?C(R3)Sn(R1)3??(1) wherein R1 is a C1-10 alkyl group, a C2-14 aryl group or the like, R2 is a C2-14 aryl group, a C2-9 heterocyclyl group, a C3-10 cycloalkyl group or the like, and R3 is a carbamoyl group, a thiocarbamoyl group, an isocyanate group, an isothiocyanate group, a formylamino group, a thioformylamino group, an isonitrile group, an urea group, a carbamate group or the like.Type: GrantFiled: April 14, 2006Date of Patent: September 29, 2009Assignee: Nissan Chemical Industries, Ltd.Inventor: Kuniaki Tatsuta
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Patent number: 7425281Abstract: The present invention provides organogermanium compounds and liquid crystal compositions comprising such a compound.Type: GrantFiled: December 2, 2005Date of Patent: September 16, 2008Assignee: Displaytech, Inc.Inventors: Michael D. Wand, Kundalika M. More, William N. Thurmes
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Patent number: 7109366Abstract: The present invention provides a composition and process using the composition for removing metal ions from aqueous process solutions. These compositions include a non-metallic compound and a suitable carrier. In one embodiment, the non-metallic compound is a thiuram. In another embodiment, the non-metallic compound can further include a dithiocarbamate. These compositions are contacted with the metal ions in the aqueous process solution having a wetting agent to form an organometallic complex precipitate. The precipitate can then be separated from the aqueous solution.Type: GrantFiled: October 29, 2004Date of Patent: September 19, 2006Assignee: Canadus Technologies LLCInventor: Peter Morton
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Publication number: 20040267037Abstract: The invention relates to a compound according to the formula (XR5−)(NR′4+), wherein X represents Si, Ge, Sn or Pb, the R groups may be the same or different, each being a monoanion chosen from the group comprising hydrogen, an alkyl group, an aryl group, an arylalkyl group, and the R′ groups may be the same or different, each representing a hydrocarbon group containing 1-10 carbon atoms. The invention also relates to a process for the preparation of a compound of formula (XR5−)(NR′4+), to an ion exchange process wherein the NR′4+ is exchanged for another cation, and to the use of (XR5−)(NR′4+) and the product of said ion exchange process as a cocatalyst in the polymerization of olefins.Type: ApplicationFiled: August 12, 2004Publication date: December 30, 2004Inventors: Sirik Deerenberg, Koop Lammertsma, Marius Schakel, Mirko Kranenburg, Adrianus Keijzer, De
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Publication number: 20040087810Abstract: In one embodiment, this invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). The SARM compounds have unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. In one embodiment, the SARM compounds bind irreversibly to the androgen receptor. In another embodiment, the SARM compounds are androgen receptor antagonists which bind irreversibly to the androgen receptor. In another embodiment, the SARM compounds are alkylating agents.Type: ApplicationFiled: February 24, 2003Publication date: May 6, 2004Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka, Leonid I. Kirkovsky, Arnab Mukherjee, Dong Jin Hwang
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Patent number: 6380278Abstract: A urethane (meth)acrylate metal salt obtained by reacting (A) one or more polyisocyanates, (B) one or more hydroxy functional (meth)acrylates, and (C) one or more metal salt polyols which are the reaction product of a metal oxide and a half ester containing a hydroxy group and a carboxylic acid group. Processes of preparing such salts and polymers prepared from such salts are also disclosed. The polymers are useful for coating and adhesive compositions prepared by radiation or peroxide curing processes.Type: GrantFiled: January 19, 2001Date of Patent: April 30, 2002Assignee: Sartomer Technology Co., Inc.Inventors: Mingxin Fan, Xiaoxing Chuck Dong, Jeffrey Allan Klang, James Horgan, Gary W. Ceska
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Patent number: 6187910Abstract: The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds.Type: GrantFiled: May 12, 1999Date of Patent: February 13, 2001Assignee: NeoRx CorporationInventor: Sudhakar Kasina
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Patent number: 6005083Abstract: The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds.Type: GrantFiled: March 28, 1997Date of Patent: December 21, 1999Assignee: NeoRx CorporationInventor: Sudhakar Kasina
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Patent number: 5973175Abstract: An ultrafine titanium dioxide powder is disclosed that can be produced by hydrothermal treating an amino titanium oxalate composition. Ultrafine titanium dioxide powders are useful in cosmetic and other applications for controlling exposure to ultraviolet (UV) light.Type: GrantFiled: February 17, 1998Date of Patent: October 26, 1999Assignee: E. I. du Pont de Nemours and CompanyInventor: Salvatore Anthony Bruno
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Patent number: 5955053Abstract: The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a thioacetamidethiourea (TATU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.Type: GrantFiled: May 6, 1996Date of Patent: September 21, 1999Assignee: Emory UniversityInventors: Luigi Gaetano Marzilli, Malgorzata Lipowska, Lory Hansen, Andrew Taylor, Jr.
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Patent number: 5914097Abstract: The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono- and di-amino acids, their esters and amides, and catecholamine-like derivatives, of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.Type: GrantFiled: June 6, 1995Date of Patent: June 22, 1999Assignee: Regents of the University of CaliforniaInventor: David L. White
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Patent number: 5859214Abstract: Compounds of general formula I ##STR1## wherein Z.sup.1, Z.sup.2, X, R.sup.2 and R.sup.3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in NMR diagnosis.Type: GrantFiled: April 15, 1994Date of Patent: January 12, 1999Assignee: Schering AktiengesellshaftInventors: Heinz Gries, Erich Klieger, Bernd Raduchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jurgen Conrad
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Patent number: 5808013Abstract: Process for the preparation of N-alkyl substituted metal carbamate solutions characterized in that a water solution of the salt of the metal of which the corresponding carbamate is to be obtained, is reacted with an organic solution, basically consisting of an aprotic solvent and a secondary amine, saturated with carbon dioxide.The above solutions can be used as catalysts in polymerization reactions of unsaturated monomers or for supporting metals on inorganic oxides.Type: GrantFiled: July 10, 1996Date of Patent: September 15, 1998Assignee: Enichem S.p.A.Inventors: Paolo Biagini, Gabriele Lugli, Fausto Calderazzo, Daniela Belli Dell'Amico, Alessandra Merigo
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Patent number: 5681543Abstract: Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuable complexing agents and complexes for diagnosis.Type: GrantFiled: August 10, 1994Date of Patent: October 28, 1997Assignee: Shering AktiengesellschaftInventors: Heribert Schmitt-Willich, Julius Deutsch, Heinz Gries, Jurgen Conrad, Reinhard Neumeier
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Patent number: 5676923Abstract: Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.Type: GrantFiled: June 7, 1995Date of Patent: October 14, 1997Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Ulrich Niedballa, Peter Mareski, Bernd Raduchel, Hanns-Joachim Weinmann, Andreas Muhler, Bernd Misselwitz
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Patent number: 5616312Abstract: The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are the same or different and are --CO--(CH.sub.2).sub.y --SH, --(CH.sub.2).sub.2 --SH, --SO.sub.2 --(SH.sub.2).sub.t --SH,--SH,--(CH.sub.2).sub.q --COOH, and --(CH.sub.2).sub.v --CONR.sup.6 R.sup.7, provided at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 is a sulfur containing moiety; n is 0 to about 10; i is 2 to about 5; j is 2 to about 5; y is 1 to about 5; z is 1 to about 6; t is 1 to about 5; q is 1 to about 5; v is 1 to about 5; R.sup.6 is H, alkyl, hydroxyalkyl, polyhydroxyalkyl, arylalkyl or alkoxyalkyl; R.sup.7 is H, alkyl, hydroxyalkyl, polyhydroxyalkyl, arylalkyl or alkoxyalkyl; and R.sup.7 can be polyamine when R.sup.6 is H.Methods for imaging using compositions of the invention are also provided.Type: GrantFiled: March 10, 1995Date of Patent: April 1, 1997Assignee: Mallinckrodt Medical, Inc.Inventor: Leonard O. Rosik
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Patent number: 5582814Abstract: Paramagnetic metal complexes of 1-(p-n-butylbenzyl)diethylenetriamine pentaacetic acid and pharmaceutically acceptable salts thereof are effective as tissue-specific MRI contrast agents, and in particular as hepatobiliary MRI contrast agents.Type: GrantFiled: April 15, 1994Date of Patent: December 10, 1996Assignee: Metasyn, Inc.Inventors: Daniel M. Scott, Randall B. Lauffer
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Patent number: 5562894Abstract: The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono- and di-amino acids, their esters and amides, and catecholamine-like derivatives, of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.Type: GrantFiled: December 17, 1993Date of Patent: October 8, 1996Assignee: Regents of the University of CaliforniaInventor: David L. White
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Patent number: 5466438Abstract: Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.Type: GrantFiled: December 27, 1993Date of Patent: November 14, 1995Assignee: ImaR.sub.x Pharmaceutical Corp.Inventors: Evan C. Unger, DeKang Shen
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Patent number: 5460799Abstract: The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.Type: GrantFiled: August 18, 1994Date of Patent: October 24, 1995Assignee: Research Corporation Technologies, Inc.Inventors: Gabriel A. Elgavish, Sung K. Kim
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Patent number: 5419894Abstract: Compounds of the general formula I: ##STR1## wherein R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## and X represents hydrogen atoms and/or metal ion equivalents, and their salts with physiologically harmless organic bases, are valuable complexing agents, complexes and complex salts for diagnostic imaging.Type: GrantFiled: March 28, 1994Date of Patent: May 30, 1995Assignee: Schering AktiengesellschaftInventors: Heinz Gries, Franz-Josef Renneke, Hanns-Joachim Weinmann
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Patent number: 5405601Abstract: The present invention provides new and structurally diverse compositions for diagnostic imaging comprising compounds of the general formula: ##STR1## wherein A is N or CR.sub.1, R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.6 -C.sub.10 aryl, where the alkyl or aryl group may be optionally substituted with one or more hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 hydroxyaryl, C.sub.6 -C.sub.10 aryloxy, --CO.sub.2 R.sub.2, --CONR.sub.3 R.sub.4, or NR.sub.3 R.sub.4 ; D is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O--, or NR.sub.5 ; E is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.6 ; F is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.7 ; R.sub.2 -R.sub.7 are as defined within; g, h, i, j, k and m may be the same or different and are an integer from one to about six; X is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H or --CONHOH.Type: GrantFiled: July 2, 1993Date of Patent: April 11, 1995Assignee: Mallinckrodt Medical Inc.Inventors: T. Jeffrey Dunn, Dennis A. Moore, Muthanadar Periasamy, Milorad M. Rogic, Rebecca A. Wallace, David H. White, Steven R. Woulfe
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Patent number: 5393908Abstract: A protected 6-trimethylstannyl dopa derivative has been synthesized for the as a precursor for the preparation of 6-[.sup.18 F]fluoro-L-dopa. The tin derivative readily reacts with electrophilic radiofluorinating agents such as [.sup.18 F]F.sub.2, [.sup.18 F]OF.sub.2 and [.sup.18 F]AcOF. The [.sup.18 F]fluoro intermediate was easily hydrolyzed with HBr and the product 6-[.sup.18 F]fluoro-L-dopa was isolated after HPLC purification in a maximum radiochemical yield of 23%, ready for human use.Type: GrantFiled: June 25, 1992Date of Patent: February 28, 1995Inventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Allyson J. Bishop, Mohammad Namavari
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Patent number: 5382421Abstract: A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which are N-carboxylated desferrioxamine B complexes with metal ions are provided.Type: GrantFiled: September 17, 1993Date of Patent: January 17, 1995Assignee: The Regents of the University of CaliforniaInventors: David L. White, Barry L. Engelstad, Kurt Muetterties
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Patent number: 5370860Abstract: The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.Type: GrantFiled: July 29, 1993Date of Patent: December 6, 1994Assignee: Research Corporation Technologies, Inc.Inventors: Gabriel A. Elgavish, Sung K. Kim
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Patent number: 5352815Abstract: The present invention provides an agent for suppression or interception of the Mailard reaction, which comprises, as the active component, an organogermanium compound represented by formula (1): ##STR1## wherein R.sub.1 to R.sub.3 may be the same or different and each of them represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydroxyl group, an O-lower alkyl group, an amino group, or a salt represented by OY (Y is a metal or a basic group-containing compound).Said agent can effectively suppress or intercept the Mailard reaction and has high safety even when administered for a long period of time.Type: GrantFiled: March 16, 1993Date of Patent: October 4, 1994Assignee: Asai Germanium Research Institute Co., Ltd.Inventors: Norihiro Kakimoto, Kunie Nakamura
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Patent number: 5344639Abstract: The present invention relates to a contrast agent for NMR imaging constituted by a complex between a chelating agent and paramagnetic metal cations, wherein said complex corresponds to the formula I: ##STR1## or a physiologically acceptable salt of this complex, in which formula: n and n' are whole numbers from 1 to 4R.sub.1 -R.sub.7 are selected from among H, a halogen, alkyl, alkoxy, aryl, alkenyl, and cycloalkyl groups; with the alkyl groups being optionally substituted by halogen, alkoxy, alkyl, nitrile, nitro or amino; >C(R.sub.6, R.sub.7) can in addition represent >C=O;the three substituents Y are identical or different and represent H or an ionic equivalent of a divalent or trivalent paramagnetic metal cation or of a physiologically acceptable cation derived from an inorganic or organic base,with the condition that at least two of the substituents Y represent ionic equivalents of paramagnetic metal cations.Type: GrantFiled: June 26, 1991Date of Patent: September 6, 1994Assignee: Medgenix Group S.A.Inventors: Kwok W. Chiu, Wassif Hussain, John R. Thornback
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Patent number: 5330743Abstract: A contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metals having at least one unpaired electron. Examples of such chelating agents include 3,6,9-tris(carboxymethyl)-1, 11-bis(dimethylamine)-3,6,9-triazaundecane; 3,6,9-tris(carboxymethyl)-1, 11-bis(diethanolamino) 3,6,9-triazaundecane; 3,6,9-tris(carboxymethyl)-1, 11-bis(tris(hydroymethyl) aminomethane)-3,6,9-triazaundecane; 3,6-bis(carboxymethyl-1,8-bis(N-carboxymethylglucosamino)-3,6-diazoctane; DTPA-bis(galactosamide), DTPA-Bis(glucosamide), DTPA-Bis(pyridoxamide), and poly-(DTPA-ethylenediamide).Type: GrantFiled: November 12, 1992Date of Patent: July 19, 1994Assignee: Magnetic Research, Inc.Inventors: Wendell A. Gibby, N. Rao Puttagunta
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Patent number: 5324503Abstract: Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.Type: GrantFiled: February 6, 1992Date of Patent: June 28, 1994Assignee: Mallinckrodt Medical, Inc.Inventors: Youlin Lin, Muthanadar P. Periasamy, Donald R. VanDeripe
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Patent number: 5316756Abstract: Compounds of the general formula I: ##STR1## R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## wherein j signifies the numbers 1 to 4 and R.sup.Type: GrantFiled: April 13, 1990Date of Patent: May 31, 1994Assignee: Schering AktiengesellschaftInventors: Heinz Gries, Franz-Josef Renneke, Hanns-Joachim Weinmann
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Patent number: 5312617Abstract: Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.Type: GrantFiled: May 22, 1992Date of Patent: May 17, 1994Inventors: Evan C. Unger, DeKang Shen
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Patent number: 5242681Abstract: The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.Type: GrantFiled: August 4, 1992Date of Patent: September 7, 1993Assignee: Research Corporation Technologies, Inc.Inventors: Gabriel A. Elgavish, Sung K. Kim
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Patent number: 5155248Abstract: Reaction products of dibutyl tin oxide with selected aromatic aminocarboxylic acids, a process for their preparation and their use as catalysts for the preparation of polyurethanes.Type: GrantFiled: November 29, 1991Date of Patent: October 13, 1992Assignee: Rhein Chemie Rheinau GmbHInventors: Volker Ullrich, Clemens Schudok
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Patent number: 5081271Abstract: Benzoic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or lower-alkyl, R.sub.2 and R.sub.4 represent hydrogen, trimethylsilyl, or trimethylgermyl, R.sub.3 represents hydrogen, lower-alkyl, trimethylsilyl, or trimethylgermyl, R.sub.5 represents hydrogen, lower-alkyl, acetyl, or hydroxy, at least one of R.sub.2 and R.sub.3 being trimethylsilyl or trimethylgermyl, and R.sub.6 means hydroxy, lower-alkoxy, or a group of the formula --NR.sub.7 R.sub.8, wherein R.sub.7 and R.sub.8 mean hydrogen or lower-alkyl, and X represents a group of the formula --COHN--, --NHCO--, --COO--, --OCO--, --COCH.dbd.CH--, --COCH.dbd.C(OH)--, or --CH.dbd.CH--, which exhibit excellent effect as differentiation-inducing agents for neoplastic cells, especially leukemia cells, or a therapeutic agent for psoriasis or immune and inflammatory diseases, and a process for the preparation thereof, are disclosed.Type: GrantFiled: March 28, 1989Date of Patent: January 14, 1992Inventor: Koichi Shudo
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Patent number: 4983630Abstract: There are provided new 2,2-difluorocyclopropylethane derivatives of general formula I ##STR1## in which A, B and R.sup.1-5 have the meanings given in the description and processes for their preparation. The compounds of the invention can be used as pesticides, especially against insects and mites.Type: GrantFiled: November 28, 1988Date of Patent: January 8, 1991Assignee: Schering AktiengesellschaftInventors: Peter Wegner, Hartmut Joppien, Gunter Homberger, Arnim Kohn
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Patent number: 4965211Abstract: Species-linked diamine triacetic acids of the formula ##STR1## wherein T is an organic species containing at least one amine, hydroxyl, or thiol functional group, L is the residue of at least one of those functional groups and R is a two or more atom long covalent bridge, are disclosed. Methods for their preparation, for the preparation of metal chelates from them and for the use of the chelates are also disclosed. In a preferred embodiment, the metal ions employed in the formation of the chelates are rare earth metal ions capable of forming fluorescent chelates which can in turn be employed in fluoroassay techniques.Type: GrantFiled: November 9, 1983Date of Patent: October 23, 1990Assignee: Irwin WiederInventors: Irwin Wieder, Robert H. Wollenberg
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Patent number: 4916247Abstract: Organometal-containing styrene derivatives of the formula I ##STR1## in which, for example, M is Si, X is 0, R.sup.1 and R.sup.2 are hydrogen, R.sup.4 to R.sup.6 are each methyl, a is zero and R.sup.7 is hydrogen or methyl, and organometal-containing compounds of the formula VII ##STR2## in which M and R.sup.1 to R.sup.6 are, for example, as defined above and Y is, for example, 4-nitrophenoxy, are valuable starting materials for the preparation of organometal-containing polymers. The polymers are suitable for the preparation of photoresists which can be developed under dry conditions, such as are required in the production of structured images, particularly in microelectronics.Type: GrantFiled: August 29, 1988Date of Patent: April 10, 1990Assignee: Ciba-Geigy CorporationInventor: Alfred Steinmann