Nitrogen Bonded Directly To The Metal Patents (Class 556/137)
  • Patent number: 10408801
    Abstract: A method of ionizing a sample is disclosed comprising performing an initial experiment comprising: (i) adding one or more reagents to an analyte sample; (ii) varying the composition and/or concentration of the one or more reagents; (iii) ionizing the analyte sample including the one or more reagents; (iv) determining the composition and/or concentration of the one or more reagents which results in a desired, improved or optimized ionization or other condition or parameter for one or more analytes of interest; and (v) determining one or more first retention times or one or more first retention time windows for the one or more analytes of interest. The method then further comprises separating an analyte sample using a first separation device and during the course of a single experimental run or acquisition varying the composition and/or concentration of one or more reagents which are added to an eluent which emerges from the first separation device.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: September 10, 2019
    Assignee: MICROMASS UK LIMITED
    Inventor: Martin Raymond Green
  • Patent number: 10406514
    Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: September 10, 2019
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Alan Dyke, Damian Mark Grainger, Jonathan Alan Medlock, Hans Guenter Nedden, Jacques Jean Marie Le Paih, Stephen James Roseblade, Andreas Seger, Vilvanathan Sivakumar, Antonio Zanotti-Gerosa
  • Patent number: 9731022
    Abstract: Disclosed is a pharmaceutical composition comprising an amide derivative or a pharmaceutically acceptable salt thereof and a non-metallic salt lubricant, which can be used as an effective cancer cell-growth inhibitor owing to its enhanced storage stability with no quality changes over time.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: August 15, 2017
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Yong Il Kim, Kyeong Soo Kim, Jin Cheul Kim, Yo Han Kim, Jae Hyun Park, Jong Soo Woo
  • Patent number: 9447130
    Abstract: The present invention relates to a process to prepare dicycloplatin under mild reactive conditions and at fast reaction rates. The process is reproducible and easy to scale up for industrial application.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: September 20, 2016
    Assignees: Syn-Nat Product Enterprise LLC, Medoc Pharmaceutical Co., Ltd.
    Inventors: Xiaozhong Liu, Jirui Xi, Ye Zhao, Liang Zhang
  • Patent number: 9321045
    Abstract: The invention relates to a method for synthesizing tethered ruthenium catalysts and novel tethered ruthenium catalysts obtainable by this methods. The method involves carrying out an “arene swapping” reaction avoiding the requirement to use complicated techniques making use of unreliable Birch reductions and unstable cyclodienyl intermediates.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: April 26, 2016
    Assignee: THE UNIVERSITY OF WARWICK
    Inventors: Martin Wills, Katherine Emma Jolley, Rina Soni
  • Patent number: 9284623
    Abstract: The present invention enables simple production of osmium tetroxide having comparable performance to that sold in reagents from a solution containing osmium. The present invention relates to a method for producing osmium tetroxide solution, the method comprising a step for using ozone or a similar oxidizing gas to oxidize a solution containing osmium and produce osmium tetroxide gas and a step for introducing the resulting osmium tetroxide gas into a recovery solution; the present invention further relates to a production apparatus therefor.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: March 15, 2016
    Assignee: National University Corporation Hamamatsu University School of Medicine
    Inventors: Kazushige Suzuki, Yoshinori Muranaka
  • Patent number: 9252369
    Abstract: The present invention relates, inter alia, to metal complexes having improved solubility, to processes for the preparation of the metal complexes, to devices comprising these metal complexes and to the use of the metal complexes. M(L)n(L?)m formula 1 where the compound contains a moiety M(L)n of the formula (2) W is equal to the formula (3).
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: February 2, 2016
    Assignee: Merck Patent GmbH
    Inventors: Rémi Manouk Anémian, Bernd Schröder, Claire De Nonencourt
  • Patent number: 9220705
    Abstract: The present invention relates to the use of certain platinum compounds including [PtCl2(cis-1,4-diaminocyclohexane)], or combinations of these compounds with a variety of other agents for treating and/or preventing the progression of colorectal cancer in mammals. In particular, the invention provides methods of treating and/or preventing oxaliplatin-refractory colorectal cancer in mammals.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: December 29, 2015
    Inventors: James David Hoeschele, Nicola Margiotta, Valentina Gandin, Emanuele Petruzzella, Cristina Marzano
  • Patent number: 9212199
    Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: December 15, 2015
    Assignee: The University of Liverpool
    Inventors: Dinesh Talwar, Weijun Tang, Chao Wang, Barbara Villa Marcos, Jianliang Xiao
  • Patent number: 9000212
    Abstract: Provided by the present invention is a method for efficient oxidation of alcohols by using, as a catalyst for dehydrogenation oxidation, a ruthenium complex which can be easily produced and easily handled and is obtainable at a relatively low cost. The invention relates to a method of producing a compound having a carbonyl group by dehydrogenation oxidation of alcohols by using as a catalyst the ruthenium carbonyl complex represented by the following general formula (1) RuXY(CO)(L) (1) (in the general formula (1), X and Y may be the same or different from each other and represent an anionic ligand, and L represents a tridentate aminodiphosphine ligand).
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: April 7, 2015
    Assignee: Takasago International Corporation
    Inventors: Taichiro Touge, Kunimori Aoki, Hideki Nara, Wataru Kuriyama
  • Patent number: 8987492
    Abstract: Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R1 is an arenesulfonyl group, and the like; R2 and R3 are a phenyl group, and the like; R10 through R14 are selected from a hydrogen atom, C1-10 alkyl group, and the like, but R10 through R14 are not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: March 24, 2015
    Assignee: Takasago International Corporation
    Inventors: Taichiro Touge, Tomohiko Hakamata, Hideki Nara
  • Publication number: 20150080592
    Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
    Type: Application
    Filed: April 15, 2013
    Publication date: March 19, 2015
    Inventors: Dinesh Talwar, Weijun Tang, Chao Wang, Barbara Villa Marcos, Jianliang Xiao
  • Patent number: 8981086
    Abstract: Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described palladium precatalysts.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: March 17, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Nicholas C. Bruno, Stephen L. Buchwald
  • Patent number: 8981024
    Abstract: The present invention relates to pre-catalysts for olefin metathesis and composition involving these pre-catalysts.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: March 17, 2015
    Assignee: Technische Universität Graz
    Inventors: Christian Slugovc, Julia Wappel
  • Publication number: 20150073165
    Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formula: (Formula (I)) where ring B is a conjugated ring system with one or more substituents. The catalysts of the invention are particularly effective in reductive amination procedures which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
    Type: Application
    Filed: April 15, 2013
    Publication date: March 12, 2015
    Inventors: Barbara Villa Marcos, Weijun Tang, Dinesh Talwar, Chao Wang, Jianjun Wu, Jianliang Xiao
  • Publication number: 20150021194
    Abstract: Solution-phase (e.g., homogeneous) or surface-immobilized (e.g., heterogeneous) electrode-driven oxidation catalysts based on iridium coordination compounds which self-assemble upon chemical or electrochemical oxidation of suitable precursors and methods of making and using thereof are. Iridium species such as {[Ir(LX)x(H2O)y(?-O)]zm+}n wherein x, y, m are integers from 0-4, z and n from 1-4 and LX is an oxidation-resistant chelate ligand or ligands, such as such as 2(2-pyridyl)-2-propanolate, form upon oxidation of various molecular iridium complexes, for instance [Cp*Ir(LX)OH] or [(cod)Ir(LX)] (Cp*=pentamethylcyclopentadienyl, cod=cis-cis,1,5-cyclooctadiene) when exposed to oxidative conditions, such as sodium periodate (NaIO4) in aqueous solution at ambient conditions.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 22, 2015
    Inventors: Stafford Wheeler Sheehan, Ulrich Hintermair, Julianne M. Thomsen, Gary W. Brudvig, Robert H. Crabtree
  • Patent number: 8906694
    Abstract: Disclosed herein are methods of detecting the presence and/or concentration of nitric oxide using organometallic complexes and changes in fluorescence.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: December 9, 2014
    Assignee: The Florida International University Board of Trustees
    Inventors: Konstantinos Kavallieratos, Nikolaos M. Tsoukias, Lissette I. Lozano-Lewis
  • Patent number: 8901323
    Abstract: Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R1 is an arenesulfonyl group, and the like; R2 and R3 are a phenyl group, and the like; R10 through R14 are selected from a hydrogen atom, C1-10 alkyl group, and the like, but R10 through R14 are not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: December 2, 2014
    Assignee: Takasago International Corporation
    Inventors: Taichiro Touge, Tomohiko Hakamata, Hideki Nara
  • Patent number: 8901337
    Abstract: Compounds comprising a metal complex having the structure [X—Y—Z-Mn+]p+.B are disclosed in which X is a histone deacetylase inhibitor, Mn+ is a DNA-binding heavy metal ion, Y is an aliphatic or aromatic spacer or is absent, and Z is a mono- or bi-dentate or chelating donor linker, or a bridging linker, P+ designates the charge on the complex ion, which may be positive, negative or absent and B is a counterion or is absent. The linker Z is labile and its metal complex X—Y—Z-Mn+ is capable of being hydrolysed in-vivo. The compounds find application in the treatment of cancer.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: December 2, 2014
    Assignee: Royal College of Surgeons in Ireland
    Inventors: Celine Josephine Marmion, Darren Griffith
  • Publication number: 20140349985
    Abstract: Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.
    Type: Application
    Filed: September 18, 2012
    Publication date: November 27, 2014
    Inventors: Xiaoping Chen, Zejun Gao, Xiaoping Meng, Shouming Wen, Yashi Yan, Feng Zhao
  • Publication number: 20140343139
    Abstract: Compositions, kits, and methods for treatment of cancers are generally provided. In some embodiments, the compositions, kits, and methods comprise a platinum (e.g., Pt(II) or Pt(IV)) compound associated with a ligand (e.g., a beta-diketonate ligand) comprising a targeting moiety. Methods of synthesizing platinum (e.g., Pt(II) or Pt(IV)) compounds associated with a ligand comprising a targeting moiety are also provided.
    Type: Application
    Filed: April 4, 2014
    Publication date: November 20, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Justin J. Wilson, Robert John Radford, Maria R. Chan, Daniel Y. Zhang
  • Patent number: 8889857
    Abstract: Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described palladium precatalysts.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 18, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Nicholas C. Bruno, Stephen L. Buchwald
  • Patent number: 8865924
    Abstract: The present invention relates to compounds and their use as ligands, in particular, in metal catalyst complexes. The ligands of the invention are capable of binding to a solid support. The invention includes the ligands in their own right and when bound to a support and the compounds may be used to prepare metal catalyst complexes.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: October 21, 2014
    Assignee: University of Leeds
    Inventors: John Blacker, Kevin Treacher, Thomas Screen
  • Patent number: 8859779
    Abstract: Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: October 14, 2014
    Assignee: Materia, Inc.
    Inventors: Steven P. Nolan, Jinkun Huang
  • Publication number: 20140303374
    Abstract: Provided by the present invention is a method for efficient oxidation of alcohols by using, as a catalyst for dehydrogenation oxidation, a ruthenium complex which can be easily produced and easily handled and is obtainable at a relatively low cost. The invention relates to a method of producing a compound having a carbonyl group by dehydrogenation oxidation of alcohols by using as a catalyst the ruthenium carbonyl complex represented by the following general formula (1) RuXY(CO)(L) (1) (in the general formula (1), X and Y may be the same or different from each other and represent an anionic ligand, and L represents a tridentate aminodiphosphine ligand).
    Type: Application
    Filed: April 18, 2012
    Publication date: October 9, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Taichiro Touge, Kunimori Aoki, Hideki Nara, Wataru Kuriyama
  • Publication number: 20140288077
    Abstract: In one aspect, the invention relates to substituted 4-phenoxyphenol analogs, derivatives thereof, and related compounds, which are useful as inhibitors of proliferating cell nuclear antigen (PCNA); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with PCNA using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: July 5, 2012
    Publication date: September 25, 2014
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventors: Naoaki Fujii, Marcelo Actis, Chandanamali Punchihewa, Michele Connelly, Sean Wu
  • Publication number: 20140255394
    Abstract: The present invention relates to the use of certain platinum compounds including [PtCl2(cis-1,4-diaminocyclohexane)], or combinations of these compounds with a variety of other agents for treating and/or preventing the progression of colorectal cancer in mammals. In particular, the invention provides methods of treating and/or preventing oxaliplatin-refractory colorectal cancer in mammals.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 11, 2014
    Inventors: James David Hoeschele, Nicola Margiotta, Valentina Gandin, Emanuele Petruzzella, Cristina Marzano
  • Patent number: 8809564
    Abstract: A manufacturing method of a platinum complex is mixing chloroplatinic acid and a chelating agent with a solvent, wherein [PtCl6]2? ions of the chloroplatinic acid is reacted with the chelating agent to form a platinum complex Pt[R]2+, wherein the chelating agent(R) is selected from ethylenediamine, 1,10-phenanthroline, 2,2?-Bipyridine, diethylenetriamine, triethylenetetraamine, phenanthroline, or bipyridine. Moreover, a method for producing a platinum catalyst on supports is mixing the chloroplatinic acid, a chelating agent and supports with a solvent to form a platinum complex, which is incorporated onto the supports. Following, a reduction step and a drying step are processed to get the platinum catalyst on the supports.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: August 19, 2014
    Assignee: National Cheng Kung University
    Inventors: Weng-Sing Hwang, Shyh-Jiun Liu, Chia-Hung Huang, Chun-Kai Huang
  • Publication number: 20140221475
    Abstract: New platinum(IV) complexes which has a strong antitumor activity and has a feature that a side effect is relatively reduced is provided. The new complex is platinum(IV) complexes with cis,cis-spiro[4,4]nonane-1,6-diamine ligand and is platinum(IV) complexes with optically active cis,cis-spiro[4,4]nonane-1,6-diamine ligand. Especially, the new complex is dichloromalonato((1S,5S,6S)-spiro[4.4]nonane-1,6-diamine)platinum(IV).
    Type: Application
    Filed: July 9, 2012
    Publication date: August 7, 2014
    Applicant: UNITECH CO., LTD.
    Inventors: Hisae Arai, Hisao Kondo, Norio Masuda
  • Publication number: 20140206869
    Abstract: A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable, of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.
    Type: Application
    Filed: September 20, 2012
    Publication date: July 24, 2014
    Inventors: Kurt Brandstadt, Simon Cook, Aswini Dash, Matthew Olsen, Avril Surgenor, Richard Taylor, Binh Nguyen, Ming-Shin Tzou
  • Patent number: 8779175
    Abstract: A coordination complex having a physiologically acceptable pKa includes a metal and a biologically active agent. The pKa of the coordination complex is less than the pKa of the biologically active agent. A pharmaceutical solution for treating a patient includes a coordination complex and water, wherein the coordination complex is at least partially soluble in the water at physiological pH and in a therapeutically efficacious concentration. A method for treating a patient includes administering a pharmaceutical solution including a coordination complex and water to a patient in need of a biologically active agent.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: July 15, 2014
    Assignee: Synthonics, Inc.
    Inventors: Thomas Piccariello, John D. Price, Robert A. Oberlender, Michaela E. Mulhare, Mary C. Spencer, Scott B. Palmer
  • Patent number: 8779176
    Abstract: The present invention relates, inter alia, to metal complexes having improved solubility, process for the preparation of the metal complexes, devices comprising these metal complexes, and the use of the metal complexes.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: July 15, 2014
    Assignee: Merck Patent GmbH
    Inventors: Rémi Manouk Anémian, Bernd Schröder, Amir Hossain Parham, Claire De Nonancourt
  • Publication number: 20140187727
    Abstract: The present invention describes the dihydrate of 1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate), a method for producing 1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate) and the hydrates thereof, and the use of 1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate) and of the hydrates thereof.
    Type: Application
    Filed: December 4, 2013
    Publication date: July 3, 2014
    Applicant: HERAEUS PRECIOUS METALS GMBH & CO. KG
    Inventors: Steffen JOST, Christian BRANDES, Holger RAUTER, Silvia WERNER, Stefanie SCHMENGLER
  • Publication number: 20140187501
    Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: December 30, 2013
    Publication date: July 3, 2014
    Applicant: Blend Therapeutics, Inc.
    Inventors: Mark T. Bilodeau, Sudhakar Kadiyala, Rajesh Shinde, Brian White, Richard Wooster, Timothy Edward Barder
  • Patent number: 8729286
    Abstract: The present invention is a platinum(II) compound comprising a beta-diketonate ligand represented by the following general formula: Or general formula: wherein R1 and R2 are independently selected from the group consisting of alkyl optionally substituted, heteroalkyl optionally substituted, and aryl optionally substituted; R3 and R4 are independently selected from the group consisting of ammonia, an optionally substituted heterocycle including at least one nitrogen, and an optionally substituted amine, or R3 and R4 can be joined together to form a bidentate ligand Z and Y are independently selected from the group consisting of O and S, provided at least one of Z and Y is S; and X— is a counterion. These compounds are useful in the treatment of cancer.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: May 20, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Justin J. Wilson
  • Publication number: 20140135390
    Abstract: Platinum compounds, modified by conjugation with thiol-containing moieties, such as cysteine or N-acetyl cystein (NAC), and pharmaceutical compositions including the modified platinum compounds. Methods for treatment of a malignancy including administering and activating the modified platinum compounds.
    Type: Application
    Filed: January 21, 2014
    Publication date: May 15, 2014
    Inventor: Amal Ayoub
  • Publication number: 20140128461
    Abstract: The invention relates to the use of a low-polyamine-content food composition for use in the treatment and/or prevention of neuropathic pain induced by a platinum salt.
    Type: Application
    Filed: November 30, 2011
    Publication date: May 8, 2014
    Inventors: David Balayssac, Mathilde Bayet-Robert, Jérémy Ferrier, Jacques Moulinoux
  • Publication number: 20140100173
    Abstract: The invention provides nitrile-containing protease inhibitors caged to ruthenium compounds. The nitrile-caged ruthenium compounds provide inactivated inhibitors that can be delivered to surface or site for activation, for example, but exposure to light. The invention also provides methods for delivering protease inhibitors to subjects for the therapeutic treatment of conditions such as cancer.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 10, 2014
    Applicants: The Ohio State University Research Foundation, Wayne State University
    Inventors: Jeremy J. Kodanko, Claudia Turro
  • Patent number: 8680309
    Abstract: A metal organic precursor, including a metal-chelate complex including a chelate including a Groups 3 to 12 metal ion, a chelating ligand, and an anion bound to the chelate, wherein the chelating ligand forms a reducing compound and a volatile material at a temperature of about 160° C. or lower, the anion forms a reducing compound and a volatile material at a temperature of about 180° C. or lower, and the metal-chelate complex is represented by Formula I: [L1-Me]pn+[A]qm???(I) wherein Me is the Groups 3 to 12 metal ion, L1 is the chelating ligand, A is the anion, n, m, p, and q are independently integers of 1 or more, n is the sum of a charge quantity of L1 and a charge quantity of Me, m is a charge quantity of A, and (n×p)=(m×q).
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: March 25, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jae Ho Lee, Young Hun Byun
  • Publication number: 20140051871
    Abstract: Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R1 is an arenesulfonyl group, and the like; R2 and R3 are a phenyl group, and the like; R10 through R14 are selected from a hydrogen atom, C1-10 alkyl group, and the like, but R10 through R14 are not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.
    Type: Application
    Filed: May 2, 2012
    Publication date: February 20, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Taichiro Touge, Tomohiko Hakamata, Hideki Nara
  • Publication number: 20140051878
    Abstract: The invention relates to new metal complexes having N-aminoamidinate ligands, more particularly metal complexes having N,N?-bis(dimethylamino)acetamidinate, N,N?-bis(dimethylamino)formamidinate, N-dimethylaminoacetamidinate or N-dimethylamino-N?-isopropyl-acetamidinate ligands as well as to their preparation and use. The metal complexes are characterized by a five-membered chelate ring. The metal complexes are formed with the metals from the main groups of the PTE, but also with transition-group elements such as tantalum (Ta), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu) or zinc (Zn), and also with precious metals such as palladium (Pd). The complexes of the invention find use as precursors for the preparation of functional layers by means of gas-phase thin-film processes such as CVD, MO-CVD and ALD. Additionally they may be used as catalysts for olefin hydroamination and for olefin polymerization.
    Type: Application
    Filed: February 20, 2012
    Publication date: February 20, 2014
    Inventors: Joerg Sundermeyer, Wolf Schorn, Ralf Karch
  • Patent number: 8637692
    Abstract: The present invention is directed to a manufacturing process for 1,2-diamino-cyclohexane-platinum(II) complexes, specifically to a manufacturing process for oxaliplatin. The process is straightforward, economical and applicable to industrial production. It comprises the reaction of (DACH)PtCl2 with silver sulfate (Ag2SO4) and the subsequent reaction of the resulting Pt sulfate complex (DACH)Pt(aq)2SO4 with barium oxalate (BaC2O4) or an equimolar mixture of barium hydroxide and oxalic acid to yield oxaliplatin in high purity with a low silver and low nitrate content.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: January 28, 2014
    Assignee: Umicore AG & Co. KG
    Inventors: Néstor Pablo Cid, Miguel Julio Novas, Agustin Alfredo Tomei
  • Patent number: 8614345
    Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of specific ruthenium catalysts, or pre-catalysts, in hydrogenation processes for the reduction of ketones and/or aldehydes into the corresponding alcohol respectively. Said catalysts are ruthenium complexes comprising a tetradentate ligand (L4) coordinating the ruthenium with: —two nitrogen atoms, each in the form of a primary or secondary amine (i.e. a NH2 or NH group) or N-alkyl imine functional groups (i.e. a C?N group), and —two sulfur atoms, each in the form of thioether functional groups.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: December 24, 2013
    Assignee: Firmenich SA
    Inventors: Francesco Santoro, Lionel Saudan, Michel Alfred Joseph Saudan, Sylvia Joyeuse Adélaïde Ada Saudan
  • Publication number: 20130336969
    Abstract: The present invention provides a method for diagnosing KRAS mutations in colorectal cancers by measuring the level of OLFM4. In another aspect, the present invention relates a method of predicting the responds to a chemotherapeutic agent of a subject suffering from a colorectal cancer: according to the present invention, the by determining the OLFM4 levels. According to the present invention, the response can be predicted by determining the OLFM4 levels. This result in turn permits the design or the adaptation of a treatment of the said subject with the said chemotherapeutic agent.
    Type: Application
    Filed: March 2, 2011
    Publication date: December 19, 2013
    Applicant: INSTITUT DE CANCEROLOGIE DE L'OUEST
    Inventors: Catherine Guette, Olivier Coqueret, Benjamin Barre, Erick Gamelin
  • Patent number: 8609864
    Abstract: The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: December 17, 2013
    Assignee: Purdue Pharmaceutical Products, L.P.
    Inventors: Yu Chen, Yi Chen
  • Publication number: 20130331566
    Abstract: Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described palladium precatalysts.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 12, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Nicholas C. Bruno, Stephen L. Buchwald
  • Patent number: 8597803
    Abstract: A light emitting composition includes a light-emitting lumophore-functionalized nanoparticle, such as an organic-inorganic light-emitting lumophore-functionalized nanoparticle. A light emitting device includes an anode, a cathode, and a layer containing such a light-emitting composition. In an embodiment, the light emitting device can emit white light.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: December 3, 2013
    Assignee: Nitto Denko Corporation
    Inventors: Jesse Froehlich, Hyun Sik Chae, Amane Mochizuki, Sheng Li
  • Patent number: 8592617
    Abstract: The present application is generally directed to ruthenium or osmium containing complexes and their use as redox mediators in electrochemical biosensors.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: November 26, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hugh Oliver Allen Hill, Christopher Paul Newman, Luet Lok Wong, Tai-Chu Lau
  • Publication number: 20130303606
    Abstract: The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a compound including platinum (e.g., platinum(II) or platinum(IV)) compound comprising a beta-diketonate ligand.
    Type: Application
    Filed: May 10, 2012
    Publication date: November 14, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Justin J. Wilson
  • Publication number: 20130267709
    Abstract: Methods for deposition of elemental metal films on surfaces using metal coordination complexes comprising bisamineazaallylic ligands are provided. Also provided are bisamineazaallylic ligands useful in the methods of the invention and metal coordination complexes comprising these ligands.
    Type: Application
    Filed: June 3, 2013
    Publication date: October 10, 2013
    Inventors: David Thompson, Jeffrey W. Anthis