Chalcogen Bonded Directly To Silicon Patents (Class 556/405)
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Patent number: 5298663Abstract: A process for the preparation of a protected phosphine oxide which comprises reacting a phosphinate ester having a protecting group on the phosphorus atom with an organomagnesium halide or an organolithium compound at a temperature of -70.degree. C. to 65.degree. C. Protected phosphine oxides so prepared are useful intermediates for the preparation of tertiary phosphine oxides and acylphosphine oxide photoinitiators.Type: GrantFiled: March 23, 1993Date of Patent: March 29, 1994Assignee: Ciba-Geigy CorporationInventors: Roger G. Hall, Peter Riebli
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Patent number: 5290935Abstract: A process for producing phosphonate esters containing the 2-(pyridyl)ethyl group by reacting a vinylpyridine with a di- or trihydrocarbylphosphite in the presence of a selected silane, protic acid, or Lewis acid is disclosed. Also disclosed are novel silylphosphonate esters containing the 2-(pyridyl)ethyl group. All of the compounds produced herein are useful as catalysts for increasing the molecular weight of polyamides.Type: GrantFiled: July 29, 1993Date of Patent: March 1, 1994Assignee: E. I. Du Pont De Nemours and CompanyInventors: David L. Thorn, Owen W. Webster, Robert C. Wheland
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Patent number: 5288888Abstract: The invention is an improved process for the large scale production of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester.Type: GrantFiled: April 28, 1993Date of Patent: February 22, 1994Assignee: American Cyanamid CompanyInventors: Kenneth E. Green, Edward R. Ruso, Mellard N. Jennings, Alex R. Jurgens, David M. Blum, Gregg B. Feigelson
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Patent number: 5278332Abstract: New derivatives of cyclohexane in substantially pure form suitable as pharmaceutical, foodstuff or as a stabilizer.Type: GrantFiled: August 5, 1992Date of Patent: January 11, 1994Assignee: Perstorp ABInventors: Matti Siren, Lars Perrson
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Patent number: 5274161Abstract: New derivatives of cyclohexane in substantially pure form suitable as a pharmaceutical, foodstuff or as a stabilizer.Type: GrantFiled: August 5, 1992Date of Patent: December 28, 1993Assignee: Perstorp ABInventors: Matti Siren, Lars Perrson
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Patent number: 5274155Abstract: A process for the preparation of compounds of formula ##STR1## and pharmaceutically acceptable salts thereof; wherein X is --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C-- or --CH.sub.2 O-- (where O is linked to Z); Z is a hydrophobic anchor R.sub.1 is hydrogen, alkyl, cycloalkyl or aryl; comprising the steps of:(A) reacting a compound of formula ##STR2## with a compound of formula ##STR3## or a compound of formula ##STR4## in the presence of an amine base or an alkali metal hydride in an organic solvent to form a compound having the formula ##STR5## (B) heating the compound of formula IX at a temperature of from about 100.degree. C. to about 200.degree. C., to form a compound of formula ##STR6## and (C) quenching the compounds of formula VIII with an acid provides the compounds of formula I.Type: GrantFiled: December 7, 1992Date of Patent: December 28, 1993Assignee: E. R. Squibb & Sons, Inc.Inventors: John K. Thottathil, David Kronenthal
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Patent number: 5233067Abstract: A method for metallizing a polymeric substrate is disclosed. The method includes contacting a surface of an etched polymeric substrate with a silane coupling agent and depositing a metallic layer over the surface. The silane coupling agent forms a chemical linkage between the substrate and the metallic layer. A coupling agent composition and a metallized polymeric substrate are also described.Type: GrantFiled: May 8, 1990Date of Patent: August 3, 1993Assignee: Rogers CorporationInventors: Gwo Swei, Kenneth W. Kristal
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Patent number: 5225584Abstract: A novel synthesis of compounds having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R.sup.3 is a C.sub.1 -C.sub.20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula:(R.sup.1 O).sub.3 Pwherein R.sup.1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula:R.sup.3 OHwherein R.sup.3 is as defined above, to produce a 1-alkoxy-1-arylmethane phosphonate ester of the formula: ##STR2## reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula:T.dbd.Type: GrantFiled: April 3, 1991Date of Patent: July 6, 1993Assignee: Tropix, Inc.Inventors: Edwards Brooks, Juo Rhou-Rong
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Patent number: 5216155Abstract: Silicon and aluminum complexes having the following formula I, II or III: ##STR1## wherein x is 0 or 1, T is H or ##STR2## each R is independently selected from the group consisting of H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.2-6 alkene, C.sub.6-12 aryl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.3-20 heteroaromatic, and combinations thereof, wherein R may further contain one or more atoms of a non-carbon element such as Si, Ge, Sn, P, and the like; Y is a cation, and Z is a multivalent cation, are prepared by reacting silica or alumina with a diol, in the presence of a base, while removing water formed during the reaction. Methods for producing such complexes starting with silica or alumina, and methods for converting such complexes into other silicon or aluminum-containing compounds, are disclosed.Type: GrantFiled: November 12, 1991Date of Patent: June 1, 1993Assignee: Washington Research FoundationInventors: Richard M. Laine, Kay A. Youngdahl
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Patent number: 5210110Abstract: Silylated acylphosphine oxides of formula I ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are defined in the specification, are highly suitable as photoinitiators for the photopolymerization of compounds which can be polymerized by means of free radicals, namely ethylenically unsaturated compounds.Type: GrantFiled: November 18, 1991Date of Patent: May 11, 1993Assignee: Ciba-Geigy CorporationInventors: Werner Rutsch, Rinaldo Husler
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Patent number: 5166198Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1 is hydroxy or amino;R.sub.2 is hydrogen or amino;R.sub.3 is hydrogen, hydroxymethyl or acyloxymethyl;R.sub.4 is hydrogen or (when R.sub.3 =H and Z is a bond or CH.sub.2) hydroxy, acyloxy, hydroxymethyl or acyloxymethyl;Z is a bond, or a group CHR.sub.8 wherein R.sub.8 is hydrogen, or (when R.sub.3 =R.sub.4 =H), R.sub.8 is hydroxy, acyloxy, hydroxymethyl or acyloxymethyl;R.sub.5 is a group of formula: ##STR2## wherein R.sub.6 and R.sub.7 are independently selected from hydrogen,C.sub.1-6 alkyl and optionally substituted phenyl.Type: GrantFiled: March 28, 1990Date of Patent: November 24, 1992Assignee: Beecham p.l.c.Inventors: Michael R. Harnden, David M. Duckworth, Halina T. Serafinowska
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Patent number: 5164522Abstract: A cationic silicone compound which can be employed in a variety of environments, such as a fiber lubricant, textile fabric softener, hair conditioner, and skin conditioner.The cationic silicone is formed from an amino silicone compound which has the following Formula (I): ##STR1## wherein a, b, and c are 0-300; d is 0-4, preferably 1;R.sub.1 comprises hydrogen, an alkyl, aryl, alkynl, alkenyl, alkyloxyalkylene group which may be unsubstituted or substituted with P,N, or S moieties;R.sub.2 is defined the same as R.sub.1 and can also be a carboxylic acid residue preferably a fatty acid residues, with the proviso that where R.sub.2 is a carboxylic acid residue, the R.sub.1 attached to the terminal N is hydrogen;R.sub.3 is defined the same as R.sub.2 and can also be alkoxy, aryloxy or oxyalkylene groups;R.sub.4 is defined the same as R.sub.3 and can also be an amino-substituted alkyl group;Z.sub.1 and Z.sub.Type: GrantFiled: June 29, 1990Date of Patent: November 17, 1992Assignee: Karlshamns ABInventors: James P. McCarthy, George H. Greene, Anthony G. DeWar
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Patent number: 5137951Abstract: Hydroxyaminomethylphosphonates of formula I ##STR1## where R.sub.1 to R.sub.5 are independently hydrogen, alkyl, cycloalkyl, aryl or phenylalkyl, R.sub.6 has the same meanings except for hydrogen, and R.sub.1 can also be trialkylsilyl, are useful stabilizers for organic materials subject to oxidative, thermal or actinic induced degradation.Type: GrantFiled: September 11, 1991Date of Patent: August 11, 1992Assignee: Ciba-Geigy CorporationInventors: Stephen D. Pastor, Ramanathan Ravichandran, Roger Meuwly
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Patent number: 5128494Abstract: A method is provided for preparing preceramic polymers and silicious ceramic materials which derive therefrom. The preceramic polymers are polysiloxanes which are synthesized by catalytically activating Si-H bonds in a hydridosiloxane starting material and replacing the activated hydrogen atoms with non-hydrogen substituents. These preceramic polysiloxanes are pyrolyzed in a selected atmosphere to give the desired ceramic product. Ceramic products which may be prepared by this technique include silica, silicon oxynitride, silicon carbide, and metal silicates.Type: GrantFiled: April 21, 1989Date of Patent: July 7, 1992Assignee: SRI InternationalInventor: Yigal Blum
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Patent number: 5108994Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is hydroxy or amino;R.sub.2 is hydrogen or amino;R.sub.3 is hydrogen, hydroxymethyl or acyloxymethyl;R.sub.4 is a group of formula: ##STR2## wherein R.sub.5 and R.sub.6 are independently selected from hydrogen, C.sub.1-6 alkyl and optionally substituted phenyl; orR.sub.3 and R.sub.4 together are: ##STR3## wherein R.sub.6 is as defined above;having antiviral activity, processes for their preparation and their pharmaceutical use.Type: GrantFiled: May 23, 1990Date of Patent: April 28, 1992Assignee: Beecham Group p.l.c.Inventors: Michael R. Harnden, Leslie J. A. Jennings
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Patent number: 5099051Abstract: Siloxanyl-phosphate mixtures are prepared by reacting cyclopolydimethylsiloxane and a silylphosphate mixture. The siloxanyl-phosphate mixture is a mixture of 5 to 30 weight percent of a monosiloxanyl-phosphate of the formula ##STR1## 70 to 85 weight percent of a disiloxanyl-phosphate of the formula ##STR2## 2 to 11 weight percent of a trisiloxanyl-phosphate of the formula wherein x has an average value of from 3 to 30.These siloxanyl-phosphate mixtures are useful in stabilizing basic polymerization catalyst such as potassium hydroxide or potassium silanolate and can either be used effectively per se or in combination with carbon dioxide.Type: GrantFiled: August 16, 1991Date of Patent: March 24, 1992Assignee: Dow Corning CorporationInventors: James A. Beck, Peter Lamont
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Patent number: 5093452Abstract: The present invention relates to a series of novel silicone phosphate organic amine salts. These compounds have one or more pendant phosphate group in the free acid form which is neutralized by a fatty amine group. The amine group will become protonated and a net positive charge will result. The phosphate will donate the proton and develop a net negative charge. This compound is more substantive and higher foaming than any of the components alone. These phosphated silicone salts by virtue of this unique salt formation is highly foaming, non irritating to eyes and skin and deposits on fiber surfaces and form effective surface modifying finishes. The compounds of the present invention are therefore very well suited to applications in the personal care market.Type: GrantFiled: September 9, 1991Date of Patent: March 3, 1992Assignee: Siltech Inc.Inventor: Anthony J. O'Lenick, Jr.
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Patent number: 5091378Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesteroleumic agents are provided which have the structure ##STR1## wherein R is OH, or salts thereof or lower alkoxy; R.sup.x is H or alkyl;X is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 CH.sub.2 CH.sub.2 -- or --CH.sub.2 O-- (where O is linked to Z);Z is a hydrophobic anchor, such as ##STR2## wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.Type: GrantFiled: April 18, 1988Date of Patent: February 25, 1992Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Michael C. Badia, Scott A. Biller, Eric M. Gordon, Michael J. Sofia
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Patent number: 5087715Abstract: This application relates to novel compositions of matter generally classified as alkanolaminofunctional siloxanes. These compositions have a structure selected from the group consisting of: ##STR1## wherein x represents an integer of from 1 to 100; y represents an integer of from 1 to 10; R.sup.1 represents a lower alkyl group; and M is an alkanolamino group selected from the group consisting of:--(CH.sub.2).sub.a N(R.sup.2)--(CH.sub.2).sub.b OR.sup.3 ; (c)and--(CH.sub.2).sub.a N.sup.+ (R.sup.2)(R.sup.4)--(CH.sub.2).sub.b OR.sup.3 Z.sup.-1 (d)Compositions of this invention exhibit utility in altering the surface activity of water.Type: GrantFiled: August 7, 1989Date of Patent: February 11, 1992Assignee: Dow Corning CorporationInventor: Steven A. Snow
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Patent number: 5073286Abstract: An alkyl and/or aryl silyl ether capped polyether surfactant useful in cleaning compositions. The polyether is described in conjunction with automatic dishwashing detergent composition having improved chlorine bleach stability comprising:(a) an active chlorine containing compound selected from the group consisting of chlorinated trisodium phosphate, chlorinated cyanuric acid and alkali metal salts thereof, 2,3-dichloro-5,5-dimethylhydantoin, hypochlorite bleach and mixtures thereof to yield available chlorine in an amount of from about 0.1 percent to 5 percent;(b) about 0.1 percent to 5 percent of a chlorine bleach stable nonionic surfactant having the general formula:Y[A.sub.1 O).sub.n (A.sub.2 O.sub.m (A.sub.3 O).sub.p (X).sub.q A.sub.4 ].sub.zwherein Y is the residue of an organic compound having from 1 to 8, preferably 1 to 4, reactive hydrogens as measured by the Zerevitinov determination method; z is a number from 1 to 8, A.sub.1, A.sub.2 and A.sub.3 are C.sub.2 to C.sub.Type: GrantFiled: November 20, 1989Date of Patent: December 17, 1991Assignee: BASF CorporationInventors: Jay G. Otten, Edward J. Parker, Michael G. Kinnaird
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Patent number: 5041586Abstract: Silylphosphate mixtures are prepared by slowly adding phosphoric acid to hexamethyldisiloxane under reflux while removing the by-produced water and after the phosphoric acid is added, the temperture is increased to from 150.degree. C. to 170.degree. C. to recover the silylphosphate mixture residue. The mixture has from 10 to 30 weight percent of a monosilyl phosphate of the formula{(CH.sub.3).sub.3 SiO}(HO).sub.2 P.dbd.O,65 to 85 weight percent of a disilyl phosphate of the formula{(CH.sub.3).sub.3 SiO}.sub.2 (HO)P.dbd.O,and 2 to 7 weight percent of a trisilyl phosphate of the formula{(CH.sub.3).sub.3 SiO}.sub.3 P.dbd.O.These silylphosphate mixtures are useful in stabilizing basic polymerization catalyst such as potassium hydroxide or potassium silanolate and can either be used effectively per se or in combination with carbon dioxide.Type: GrantFiled: November 29, 1990Date of Patent: August 20, 1991Assignee: Dow Corning CorporationInventors: James A. Beck, Peter Lamont
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Patent number: 5017716Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH, lower alkoxy or lower alkyl; R.sup.x is H or alkyl;X is --O-- or --NH--;n is 1 or 2Z is a hydrophobic anchor, such as ##STR2## wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.Type: GrantFiled: December 1, 1989Date of Patent: May 21, 1991Assignee: E.R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Scott A. Biller, Eric M. Gordon
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Patent number: 4992429Abstract: Disclosed are novel substituted cyclohexenyl phosphinylhydroxybutyrates as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: ##STR1## and pharmaceutically acceptable salts thereof.Type: GrantFiled: August 24, 1989Date of Patent: February 12, 1991Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: John W. Ullrich, Kent W. Neuenschwander, John R. Regan
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Patent number: 4970138Abstract: An aqueous damping solution for the offset printing process contains a hydrolysis product of a compound of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl of 1 to 9 carbon atoms or aryl of 6 to 12 carbon atoms, or a condensate of this hydrolysis product.Type: GrantFiled: December 14, 1988Date of Patent: November 13, 1990Assignee: BASF AktiengesellschaftInventors: Harald Lauke, Gregor Schuermann
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Patent number: 4960882Abstract: The invention relates to a composition of matter comprising compounds selected from the class consisting of ##STR1## and ##STR2## This process can be carried out in these ways: (A) as ligands in a liquid membrane phase for selectively; and competitively separating desired metal ions from mixtures with other ions in a separate source phase and transporting these ions to a separate receiving phase, with both of which the liquid membrane phase is in interfacial contact long enough to effect substantial removal of the desired ions from the source phase and transporting them to the receiving phase from which they are recovered, (B) as covalently bonded to silica gel supported in a column through which the multiple ion solution is first flowed, followed by receiving liquid, and (C) as ligand in an organic liquid filling pores or apertures in the wall of a hollow fiber in a bundle of hollow fibers on opposite sides of which flow the multiple ion solution and the receiving liquid.Type: GrantFiled: December 12, 1988Date of Patent: October 2, 1990Assignee: Brigham Young UniversityInventors: Jerald S. Bradshaw, Reed M. Izatt, Virginia B. Christensen
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Patent number: 4956477Abstract: Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C.sub.1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a compound having the formula: ##STR2## with an R-ylating agent (e.g., R.sub.2 SO.sub.4) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: ##STR3## are produced by reacting a compound having the formula: ##STR4## wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula ##STR5## are produced by reacting a compound of the formula ##STR6## with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups.Type: GrantFiled: September 22, 1989Date of Patent: September 11, 1990
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Patent number: 4948918Abstract: A process for the production of .alpha.-aminoalkylphosphonic acids or salts thereof of the formula A ##STR1## wherein R.sup.1 represents hydrogen, alkyl having from 1 to 4 carbon atoms or CH.sub.2 --C.sub.6 H.sub.5 and X hydrogen or a metal cation, which comprises reacting a compound of the formula B ##STR2## in which R.sup.1 has the same meaning as in formula A and Mp.sym. represents hydrogen or a p-valent metal cation, with a hypohalite of a p-valent metal cation, and isolating the metal salt produced or acidifying the reaction mixture obtained to produce the .alpha.-aminoalkyl-phosphonic acid.Type: GrantFiled: June 29, 1989Date of Patent: August 14, 1990Assignee: Hoechst AktiengesellschaftInventors: Hans-Jerg Kleiner, Gunter Bartels
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Patent number: 4937369Abstract: A compound of formula: ##STR1## in which X.sup.1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X.sup.2 is a group -0.sup..crclbar. or a precursor of such a group, n is 2, 3 or 4, Y is a group --N.sup..sym. R.sub.3 A.sup..crclbar. wherein each R, which may be the same or different, is a C.sub.1 -C.sub.4 alkyl group and A.sup..crclbar. is an anion present when X.sup.2 is an electrically neutral group or Y is ##STR2## wherein R.sup.1 together with X.sup.2 forms a direct bond between the nitrogen and the phosphorus atoms.Type: GrantFiled: March 27, 1989Date of Patent: June 26, 1990Assignee: Biocompatible, Ltd.Inventors: Dennis Chapman, Aziz A. Durrani
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Patent number: 4900857Abstract: New phosphorus-containing organo functional silane are produced through reactions such as condensation or Michael's addition reactions of hydroxyl-containing and/or methylol-containing phosphorus compounds and organo-functional silanes having at least one active hydrogen associated with a nitrogen in the organo moiety or an isocyanato, anhydride, alkene or epoxy moiety. The reaction can be conducted at a temperature in the range of around less than ambient to around 150.degree. C. with or without a solvent in a molar ratio of around 1:1 to around 1:4 of the phosphorus-containing compound to the silane.Type: GrantFiled: April 29, 1988Date of Patent: February 13, 1990Assignee: PPG Industries, Inc.Inventor: Michael W. Klett
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Patent number: 4804770Abstract: A process is provided for preparing the keto-phosphonate ##STR1## in enantiomerically homogeneous form, by reacting the anhydride ##STR2## with S-.alpha.-methylbenzylamine to effect diastereoselective opening of the anhydride to give a mixture of amides ##STR3## separating the amides, for example, by frictional crystallization, and converting the desired amide IVA (which is obtained in high yield from the anhydride) to enantiomerically homogeneous ketophosphonate in high yield and on a large scale.The so-formed ketophosphonate is useful in the synthesis of compactin as well as 7-substituted-(3,5-dihydroxy)-hept-6-enoic and -heptanoic acid HMG-CoA reductase inhibitors.Type: GrantFiled: April 29, 1988Date of Patent: February 14, 1989Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4772408Abstract: A silicone/silicate containing antifreeze characterized by dilute aqueous stability includes phosphonate silanes characterized by the following formula: ##STR1## wherein a is 0 or 1, b is 1 or 2, c is 0 or 1, R.sup.1 and R.sup.3 are selected from the group consisting of hydrogen, monovalent hydrocarbon radicals and substituted monovalent hydrocarbon radicals, R.sup.2 is a divalent hydrocarbon radical selected from the group consisting of alkylene, arylene and alicyclic radicals, Z is a hydrolyzable moeity attached to silicon, and X is a member selected from the group consisting of hydrogen, monovalent hydrocarbon radicals, substituted monovalent hydrocarbon radicals, and a monovalent cation, the phosphonate silane having an appropriate hydrophile/hydrophobe balance and being present in an amount sufficient to stabilize the silicate.Type: GrantFiled: May 6, 1987Date of Patent: September 20, 1988Assignee: First Brands CorporationInventors: Paul H. Mohr, Enrico J. Pepe
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Patent number: 4721800Abstract: A compound of formula: ##STR1## in which X.sup.1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X.sup.2 is a group --O.sup..crclbar. or a precursor of such a group, n is 2, 3 or 4, Y is a group --N.sup..sym. R.sub.3 A.sup..crclbar. wherein each R, which may be the same or different, is a C.sub.1 -C.sub.4 alkyl group and A.sup..crclbar. is an anion present when X.sup.2 is an electrically neutral group or Y is ##STR2## wherein R.sup.1 together with X.sup.2 forms a direct bond between the nitrogen and the phosphorus atoms.Type: GrantFiled: September 18, 1985Date of Patent: January 26, 1988Assignee: Biocompatibles Ltd.Inventors: Dennis Chapman, Aziz A. Durrani
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Patent number: 4707286Abstract: A stabilizer for glycol or glycol ether based aqueous coolant compositions comprising a combination of certain organic phosphonate compounds and certain organic silicon compounds, and coolant compositions containing such a stabilizer and methods of stabilizing coolant compositions by the addition of such stabilizer.Type: GrantFiled: December 16, 1985Date of Patent: November 17, 1987Assignee: Nalco Chemical CompanyInventor: Richard P. Carr
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Patent number: 4689123Abstract: As novel compounds, ethane tetraphosphonate esters, including octaalkyl and trimethylsilyl esters, and ethylene tetraphosphonic acid, as well as new compositions including a mixture of the acid with tetramethyl methylene diphosphonic acid, and a process for the preparation thereof.Type: GrantFiled: December 23, 1986Date of Patent: August 25, 1987Assignee: The Dow Chemical CompanyInventor: Stephen A. Noding
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Patent number: 4676919Abstract: A buffer and silicone/silicate-containing antifreeze concentrate characterized by storage stability and minimized corrosiveness toward metals when diluted to make an antifreeze.Type: GrantFiled: July 10, 1985Date of Patent: June 30, 1987Assignee: First Brands CorporationInventor: Eugene A. Zientek
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Patent number: 4650609Abstract: Compounds having a quinodimethane or a 7,8-dihydroquinodimethane nucleus and four substituted phosphinyl groups at the 7- and 8-positions are disclosed. A process for preparing the specified compounds is also disclosed.Type: GrantFiled: June 25, 1985Date of Patent: March 17, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: David R. Brittelli
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Patent number: 4645847Abstract: Functionalized phenylene group-containing organopolysiloxanes, comprising a plurality of identical or different units of the formula: ##STR1## where in each case all three possible isomers in relation to the position of the SiO.sub.3/2 --R.sup.1 substituents on the phenylene group can be present concurrently, in which the bridge groups R.sup.1 represent the groups --CH.sub.2 --CH.sub.2 -- or CH.sub.3 --CH<, X represents Cl, Br, CH.sub.2 Cl, P(C.sub.6 H.sub.5).sub.2, and Ch.sub.2 P(C.sub.6 H.sub.5).sub.2, and the free valences of the oxygen atoms are saturated by silicon atoms of other groups of formula (1) and/or by cross-linking agents. Also disclosed is a process for the preparation of said polysiloxanes.Type: GrantFiled: May 21, 1986Date of Patent: February 24, 1987Assignee: Degussa AktiengesellschaftInventors: Peter Panster, Peter Kleinschmit
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Patent number: 4643839Abstract: The reaction product of phosphorous acid, formaldehyde, and monomeric or polymeric alkoxysilanes having one or more aminoalkylene groups are useful as gelation inhibitors for aqueous glycol solutions.Type: GrantFiled: April 16, 1984Date of Patent: February 17, 1987Assignee: The Dow Chemical CompanyInventors: Richard A. Pierce, David A. Wilson
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Patent number: 4640790Abstract: An improved dispersant for magnetic media, comprising the reaction product of a phosphate ester and an alkali siliconate silylalkylphosphonate, is described. The dispersant can provide comparable magnetic properties in magnetic media at lower levels than are necessary for currently employed phosphate ester dispersants. A magnetic coating composition and a process for producing magnetic recording media, based on said improved dispersant, are also disclosed.Type: GrantFiled: July 14, 1986Date of Patent: February 3, 1987Assignee: Dow Corning CorporationInventors: Judith M. Sylvester, David J. Kimball
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Patent number: 4471131Abstract: This disclosure relates to novel silyl esters of N-phosphonomethylglycine useful as post-emergence herbicides.Type: GrantFiled: September 27, 1983Date of Patent: September 11, 1984Assignee: Monsanto CompanyInventor: John E. Franz
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Patent number: 4448980Abstract: In an improved catalytic process for preparing trialkylsilyl ethers from trialkylsilyl compounds and carbonyl group-containing compounds, the improvement consisting of using an organic or inorganic bifluoride (HF.sub.2.sup..crclbar.) as the catalyst.Type: GrantFiled: September 22, 1983Date of Patent: May 15, 1984Assignee: E. I. Du Pont de Nemours and CompanyInventor: Dotsevi Y. Sogah
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Patent number: 4416830Abstract: This invention relates to phosphorus-containing compounds having the formula: ##STR1## wherein A=O or S, Z=O or S and X and Y=various substituents.Type: GrantFiled: March 3, 1981Date of Patent: November 22, 1983Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Michael Morr, Maria-Regina Kula
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Patent number: 4370255Abstract: What is disclosed are novel compositions of matter which are alkali siliconate silylalkylphosphonates which are capable of stabilizing water soluble silicates and which are capable of inhibiting corrosion of metals in aqueous systems.Type: GrantFiled: March 18, 1981Date of Patent: January 25, 1983Assignee: Dow Corning CorporationInventor: Edwin P. Plueddemann
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Patent number: 4367154Abstract: Glycol concentrates containing alkali metal silicates are rendered gellation resistant by the addition of phosphonates having one of the formulas,(I) (RO).sub.3-m (R').sub.m Si--R.sup.2 --O--P(O) (OR.sup.3)(R.sup.4),(II) [(RO).sub.3-m (R').sub.m Si--R.sup.2 --O--.sub.2 P(O)(R4)or(III) mixtures of I and II,wherein m is 0-2R, R.sup.3, R.sup.4 are alkyl groups of 1-4 carbons,R' is an alkyl group of 1-4 carbons, phenyl, and aralkyl group of 7-10 carbons, andR.sup.2 is an alkylene group of 1-4 carbons.Type: GrantFiled: July 29, 1981Date of Patent: January 4, 1983Assignee: The Dow Chemical CompanyInventor: Robert T. Jernigan
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Patent number: 4308263Abstract: The invention relates to phosphonoformic acid hydrazide compounds of the formula ##STR1## and salts thereof wherein R represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl radical. The compounds are useful as antiviral agents, particularly against herpes viruses.Also included in the invention are processes for preparing said phosphonoformic acid hydrazide compounds, compositions and medicaments containing said phosphonoformic acid hydrazide compounds and methods for the use of said compounds and compositions.Type: GrantFiled: June 20, 1980Date of Patent: December 29, 1981Assignee: Bayer AktiengesellschaftInventors: Hermann Oediger, Folker Lieb, Gert Streissle
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Patent number: 4296042Abstract: This process relates to the synthesis of unsaturated aliphatic esters useful as insect sex attractants, including gossyplure, the insect sex pheromone of the pink bollworm moth, Pectinophora gossypiella, and intermediates therefor. The process utilizes a cyclic phosphonium (Wittig) reagent.Type: GrantFiled: June 18, 1980Date of Patent: October 20, 1981Assignee: Syntex (U.S.A.) Inc.Inventors: Joseph M. Muchowski, Michael C. Venuti
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Patent number: 4220556Abstract: Novel heterogeneous silylhydrocarbyl phosphine transition metal complex catalysts and intermediates therefor are prepared by (a) the selective monoaddition of silane having chlorine, alkoxy or acyloxy groups to an .alpha., .omega.-diene, (b) followed by the addition of a phosphine to the resulting .omega.-alkenyl silanes to form the corresponding silylalkyl phosphines, (c) which are then covalently anchored as such or in the form of their transition metal complexes via condensation of their reactive silane substituents with hydroxy groups of silica and metal oxides, (d) optionally followed by complexing the free phosphine groups of anchored silylalkyl phosphines with transition metal compounds.Type: GrantFiled: January 19, 1979Date of Patent: September 2, 1980Assignee: Exxon Research & Engineering Co.Inventors: Alexis A. Oswald, Lawrence L. Murrell
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Patent number: 4206156Abstract: New hydroxyaminohydrocarbonphosphonic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or acyl,R.sup.2 is hydrogen, lower alkyl, ar(lower)alkyl or acyl, andA is lower alkylene, lower alkenylene or hydroxy(lower)alkylene,or the esters at the phosphono group thereof or the pharmaceutical acceptable salt thereof, and production and use thereof.Type: GrantFiled: April 17, 1978Date of Patent: June 3, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takashi Kamiya, Masashi Hashimoto, Keiji Hemmi, Hidekazu Takeno