Plural Ether Oxygens Or Thioether Sulfurs Attached Indirectly To The Phosphorus By Acyclic Nonionic Bonding Patents (Class 558/186)
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Patent number: 11859054Abstract: A method of preparing an alkoxy-functional organosilicon compound is provided. The method comprises reacting (A) an initial organosilicon compound and (B) an alcohol component in the presence of (C) a catalyst, thereby preparing the alkoxy-functional organosilicon compound. The initial organosilicon compound (A) comprises at least one alkoxysilyl group. The alcohol component (B) comprises an organic alcohol. The catalyst (C) comprises (C1) an ammonium carboxylate compound or (C2) a titanate compound. A reaction product comprising an alkoxy-functional organosilicon compound prepared in accordance with the method, and a composition comprising the reaction product, are also provided. The alkoxy-functional organosilicon compound, and the reaction product and composition comprising the same, are prepared in increased purity under functional group-tolerant conditions.Type: GrantFiled: September 9, 2020Date of Patent: January 2, 2024Assignee: Dow Silicones CorporationInventors: Marc-André Courtemanche, Michael Salvatore Ferritto, Nisaraporn Suthiwangcharoen
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Patent number: 11555161Abstract: A grease composition for resin lubrication, the grease composition to be applied to a sliding surface made of resin, the grease composition containing: a fluorine-based base oil (a kinematic viscosity at 40° C. of 300 mm2/s or higher) and a synthetic hydrocarbon oil as base oils; a fluorine-based thickener, and a lithium soap thickener or a lithium complex soap thickener as thickeners; and a fluorine-based surfactant and an extreme pressure additive as additives; and a resin sliding member (slide switch) having a sliding surface made of resin, the sliding surface provided by application with the grease composition.Type: GrantFiled: March 10, 2022Date of Patent: January 17, 2023Assignee: MINEBEA MITSUMI Inc.Inventors: Daiki Yamamoto, Yusuke Asai, Motojiro Tsuna
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Patent number: 9328317Abstract: This invention is directed to a composition capable of imparting surface effects to a liquid by contacting the liquid with a partially fluorinated phosphate with an ammonium cation (NH2R1R2)+ wherein R1 and R2 are independently linear or branched organic groups containing at least one carboxylate moiety and one amino moiety, and optionally be substituted, interrupted, or both with oxygen, sulfur, or nitrogen-containing moieties, or with cyclic alkyl or aryl moieties containing up to 10 carbon atoms.Type: GrantFiled: February 20, 2012Date of Patent: May 3, 2016Assignee: THE CHEMOURS COMPANY FC, LLCInventors: Sheng Peng, Allison Mary Yake, Xianjun Meng
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Patent number: 9188191Abstract: A vibrationproof device which is a liquid sealed vibrationproof device includes a tubular first mounting member (3) that is connected to either one of a vibration generating portion and a vibration receiving portion, a second mounting member (4) that is connected to other one, an elastic body (5) that elastically connects the first mounting member (3) and the second mounting member (4), and a partition member (8) that partitions a liquid chamber (7) of the inside of the first mounting member (3) into a main liquid chamber (7A) of an upper side having the elastic body as a portion of a wall surface and an auxiliary liquid chamber (7B) of a lower side, and a restricting passage (80) which communicates with the main liquid chamber (7A) and the auxiliary liquid chamber (7B).Type: GrantFiled: June 10, 2010Date of Patent: November 17, 2015Assignee: BRIDGESTONE CORPORATIONInventors: Yoshinori Matsumoto, Motohiro Yanagida, Akira Ueki, Masaaki Ohashi, Yasuyuki Nagashima, Yutaka Higuchi
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Patent number: 9102779Abstract: A flexible polyurethane foam with improved resistance to discoloration from oxidation is disclosed. Such discoloration may be due to exposure to oxides of nitrogen, for example, the oxides commonly found in burnt gas fumes. The foam may be used for applications such as intimate apparel and other consumer products that need extended term color stability. The foam composition includes high levels of reactive and non-reactive phosphite esters that improve color stability without disadvantage to the foam's physical and aesthetic properties during and after production.Type: GrantFiled: August 8, 2013Date of Patent: August 11, 2015Assignee: Wm. T. Burnett IP, LLCInventor: Scott Christopher Magness
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Publication number: 20140371328Abstract: The present invention relates to topical compositions comprising resveratrol in a liquid crystal gel network formed by a phosphate ester surfactant and a co-emulsifier. The present invention also relates to the process to make such compositions.Type: ApplicationFiled: September 24, 2012Publication date: December 18, 2014Applicant: DSM IP ASSETS B.V.Inventors: Juana Lucia Flores-Candia, Karina Hecker
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Publication number: 20140323753Abstract: An emulsifier for emulsion polymerization contains a compound represented by the following general formula (I).Type: ApplicationFiled: July 9, 2014Publication date: October 30, 2014Inventors: Asako OGASAWARA, Masayuki HASHIMOTO
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Patent number: 8846968Abstract: The present invention relates to an intermediate (12) of lycopene of 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecantriene of formula, (12) and its intermediate of 4-methyl-5,5-dialkoxyl-1-pentenyl-1-phosphonic acid dialkyl ester of formula (10), and their preparation methods. The process route is simple, the starting materials are available easily, the cost is low, and it is valuable in industry.Type: GrantFiled: December 3, 2012Date of Patent: September 30, 2014Assignees: Shaoxing University, Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical FactoryInventors: Runpu Shen, Chunlei Lv, Xiaoyue Jiang, Xuejun Lao, Weidong Ye, Luo Liu, Xiaohua Song, Chunlei Wu
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Publication number: 20140242798Abstract: A polishing composition of the present invention is used for polishing an object containing a phase-change alloy and is characterized by containing an ionic additive. Examples of the ionic additive include a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and a cationic water-soluble polymer.Type: ApplicationFiled: September 28, 2012Publication date: August 28, 2014Applicant: FUJIMI INCORPORATIONInventors: Yoshihiro Izawa, Yukinobu Yoshizaki
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Publication number: 20140123876Abstract: The invention relates to a hydroxy compound of formula (I) wherein n is an integer equal to or higher than 1 as an intermediate for the preparation of compounds of formulae (IIa) and (IIIb) as defined in the specification that can be used as water and oil resistance agents. The invention further relates to water and oil resistance compositions containing compounds (IIa) and (IIb).Type: ApplicationFiled: June 1, 2012Publication date: May 8, 2014Applicant: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.Inventors: Simonetta Antonella Fontana, Claudio Adolfo Pietro Tonelli, Piero Gavezotti
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Publication number: 20140044775Abstract: The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.Type: ApplicationFiled: September 18, 2013Publication date: February 13, 2014Applicants: University of Rochester, The Los Angles Biomedical Research Institute at Harbor-UCLA Medical Center, University of GuelphInventors: Robert H. Notter, Zhengdong Wang, Adrian L. Schwan, Zhongyi Wang, Jason A. Davy, Alan J Waring, Frans Walther, Larry M. Gordon
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Publication number: 20140005434Abstract: The present invention relates to an intermediate (12) of lycopene of 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecantriene of formula, (12) and its intermediate of 4-methyl-5,5-dialkoxyl-1-pentenyl-1-phosphonic acid dialkyl ester of formula (10), and their preparation methods. The process route is simple, the starting materials are available easily, the cost is low, and it is valuable in industry.Type: ApplicationFiled: December 3, 2012Publication date: January 2, 2014Applicants: Shaoxing University, Zhejiang Medicine Co., Ltd. XinchangInventors: Runpu Shen, Chunlei LV, Xiaoyue Jiang, Xuejun Lao, Weidong Ye, Luo Liu, Xiaohua Song, Chunlei Wu
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Publication number: 20130260156Abstract: The present invention relates to the use of perfluorinated compounds as a surface coating to counteract the formation of fouling. The present invention also relates to a method for producing a surface coating capable of preventing the formation of fouling, this method comprising the application of a polar solution of a perfluorinated compound followed by a heat cycle conducted at controlled temperatures.Type: ApplicationFiled: November 30, 2011Publication date: October 3, 2013Applicant: S.T. SPECIAL TANKS SRLInventors: Serena Biella, Giuseppe Cattaneo, Pierangelo Metrangolo, Giuiseppe Resnati
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Publication number: 20130194364Abstract: Anti-kogation agents and ink compositions containing it. Such anti-kogation agent has the formula (I) or (II) wherein R is an alkyl group having from 1 to 10 carbon atoms and n is an integer ranging from 3 to 10. A disclosed ink composition includes an ink vehicle, from about 0.1 to about 10 weight percentage of colorants and from about 0.01 to about 10 weight percentage of the anti-kogation agents.Type: ApplicationFiled: September 24, 2010Publication date: August 1, 2013Applicant: Hewlett-Packard Developement Company, L.P.Inventors: Paul Tyrell, Robert A. Brunck, Kevin P. DeKam, Garry Hinch
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Publication number: 20130158284Abstract: The invention relates to a method for producing phosphoric acid triesters of formula (I). According to said method, phosphoric acid or a phosphoric acid derivative selected from orthophosphoric acid, tetraphosphoric decaoxide and polyphosphoric acid is reacted with alkoxylated alcohols of formulae (II) R1—(OA1)x—OH, (III) R2—(OA2)y—OH, and (IV) R3—(OA3)z—OH, in the molar ratio phosphoric acid or phosphoric acid derivative to alkoxylated alcohol of 1:2.5 to 1:3.3, at between 200 and 240° C.Type: ApplicationFiled: February 5, 2013Publication date: June 20, 2013Applicant: CLARIANT FINANCE (BVI) LIMITEDInventor: Clariant Finance (BVI) Limited
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Publication number: 20130109819Abstract: The invention relates to a mono-substituted phosphinic acid and to the use thereof as a regulator in radical polymerization. Such regulators do not result in the formation of poorly soluble salts, and in addition, the polymers produced with the regulators according to the invention are characterized by a uniform polymerization degree having a narrow size distribution. In addition, the invention relates to a method for producing such mono-substituted phosphinic acids.Type: ApplicationFiled: July 19, 2011Publication date: May 2, 2013Applicant: SIKA TECHNOLOGY AGInventors: Ueli Sulser, Lukas Frunz, Jörg Zimmermann
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Publication number: 20130030066Abstract: The invention relates to a polymer composition containing i) styrene polymer(s) and ii) phosphorylated polyether(s) with from 0.5 to 40% by weight phosphorus content, the main chain of which is formed exclusively from carbon atoms and from oxygen atoms, and which has at least three terminal and/or pendant OH groups, where these have been substituted with where ˜ indicates the bond to the polymer skeleton of the polyether; Y is O or S; t is 0 or 1; R1 and R2, being identical or different, are H, C1-C18-alkyl, C2-C18-alkenyl, C2-C18-alkynyl, C3-C10-cycloalkyl, C6-C10-aryl, furyl, C6-C10-aryl-C1-C10-alkyl, OR3, SR3, NR3R4, COR3, COOR3 or CONR3R4, or R1 and R2 form, together with the phosphorus atom P, a 4-8-membered ring system; R3 and R4, being identical or different, are H, C1-C16-alkyl, C2-C16-alkenyl, C3C16-alkynyl, C3-C10-cycloalkyl, C6-C10-aryl or C6-C10-aryl-C1-C10-alkyl, and/or polycarbonates containing phosphorus-containing group(s) of the general formula (I).Type: ApplicationFiled: July 27, 2012Publication date: January 31, 2013Applicant: BASF SEInventors: Klaus Hahn, Sabine Fuchs, Ingo Bellin, Patrick Spies, Maximilian Hofmann, Peter Deglmann, Klemens Massonne, Hartmut Denecke, Christoph Fleckenstein, Geert Janssens, Anna Müller-Cristadoro, Bernd Bruchmann
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Publication number: 20120172613Abstract: Phosphate ester compounds are prepared by reacting phosphoryl chloride with at least one mono(alkylene glycol) monoether or poly(alkylene glycol) monoether, or a mixture at least one mono(alkylene glycol) monoether or poly(alkylene glycol) monoether and at least one alkylene glycol or polyalkylene glycol, in the presence of at least three moles per mole of phosphoryl chloride of a pyridinyl compound that is devoid of aliphatic nitrogen atoms.Type: ApplicationFiled: September 24, 2010Publication date: July 5, 2012Applicant: Dow Technologies LLCInventor: Nicole L. Wagner
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Publication number: 20120135604Abstract: There are provided a processing liquid that is capable of suppressing pattern collapse of a fine metal structure, such as a semiconductor device and a micromachine, and a method for producing a fine metal structure using the same. The processing liquid for suppressing pattern collapse of a fine metal structure, contains a phosphate ester and/or a polyoxyalkylene ether phosphate ester, and the method for producing a fine metal structure, uses the same.Type: ApplicationFiled: July 21, 2010Publication date: May 31, 2012Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Masaru Ohto, Hiroshi Matsunaga, Kenji Yamada
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Publication number: 20120136119Abstract: The present invention relates to the use of Styrenated Phenol Ethoxylates as surfactants in emulsion polymerization. The present invention further relates to the use of both anionic and nonionic Styrenated Phenol Ethoxylates in emulsion polymerization. Latexes with small average particle and narrow particle size distributions are obtained. Prepared latexes also have low coagulum levels and exhibit excellent mechanical and chemical stability.Type: ApplicationFiled: November 28, 2011Publication date: May 31, 2012Applicant: Ethox Chemicals, LLCInventors: Lawrence C. Davis, Edward R. Godwin, Charles V. Hinton, James T. Tanner
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Publication number: 20120053057Abstract: The present invention provides an amphiphile of the formula (I) as described hereinafter. The invention further relates to a process for preparing the amphiphile and to a composition comprising the amphiphile and a sparingly water-soluble active ingredient. It further relates to a process for producing the composition by contacting the amphiphile and the active ingredient, and to the use of the amphiphile for solubilizing a sparingly water-soluble active ingredient in aqueous solutions. The invention also relates to the use of the amphiphile in an agrochemical formulation comprising the amphiphile and a pesticide for controlling phytopathogenic fungi and/or unwanted vegetation and/or unwanted insect or mite infestation and/or for regulating the growth of plants, and finally to plant propagation material comprising the amphiphile.Type: ApplicationFiled: August 31, 2011Publication date: March 1, 2012Applicant: BASF SEInventors: Anna CRISTADORO, Holger TÜRK, Michael ISHAQUE, Rabie AL-HELLANI
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Publication number: 20120037036Abstract: The present invention provides compounds which are liquid at a temperature of 20° C. and a pressure of 101325 Pa and are of the general formula (I) [R—O(SO)a(EO)b(CH2CHCH3O)c(BO)d]x—[PO—(OH)3-x]y—R4z, where R=cardanol radical, R4=H, M+ or alkyl having 1 to 3 C atoms, SO=styrene oxide, EO=ethylene oxide, BO=butylene oxide and a=0 to 3, b=0 to 100, preferably at least 1, c=0 to 20, d=0 to 3, x=1 to 3, y=0 or 1, with the proviso that y+z is =1, that if z=1 also x is =1, that when a, c and d are =0, b is from 1 to 15, preferably from 6 to 10, that when c or d is other than 0, one of the other indices a to d is likewise other than 0, and that the sum a+b+c+d is greater 3, a process for preparing them, compositions comprising these compounds, and the use thereof.Type: ApplicationFiled: August 9, 2011Publication date: February 16, 2012Applicant: EVONIK GOLDSCHMIDT GMBHInventors: Thomas Veit, Frank Kleinsteinberg, Jochen Mergenthaier, Stefanie Redeker, Anja Christofzik, Andre Brötzmann, Phillippe Favresse, Martin Glos, Frank Schubert
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Patent number: 8062512Abstract: Processes are provided for separating bitumen from oil sands and from other bitumen-containing compositions.Type: GrantFiled: December 31, 2009Date of Patent: November 22, 2011Assignee: Vary Petrochem, LLCInventors: Robert C. Yeggy, Vito J. Altavilla
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Publication number: 20110229427Abstract: The invention relates to phosphoric acid esters containing A) at least one structural unit derived from substances of constituent a), the substances of constituent a) being selected from orthophosphoric acid and at least one of the derivatives thereof; B) at least one structural unit derived from substances of constituent b), the substances of constituent b) being selected from at least one compound of formula (I) R2—O—(CH2CH2O)U(C3H6O)V(DO)w—H; and C) at least one structural unit derived from substances of constituent c), the substances of constituent c) being selected from at least one polyol which has more than 2 OH groups and can also carry at least one alkoxylate group. The alkoxylate groups are respectively formed from at least one unit selected from CH2CH2O, C3H6O and C4H8O units that can respectively be arranged in a block or in a statistically distributed manner inside the alkoxylate groups.Type: ApplicationFiled: July 29, 2008Publication date: September 22, 2011Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Peter Klug, Franz-Xaver Scherl, Waltraud Simsch, Adelgunde Oberhauser
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Publication number: 20110230449Abstract: The invention relates to alkoxylated phosphoric acid triesters of formula (I) wherein x, y and z respectively stand for a number between 51 and 200. The alkoxylated phosphoric acid triesters of formula (I) are characterised especially by advantageous thickening properties.Type: ApplicationFiled: July 29, 2008Publication date: September 22, 2011Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Peter Klug, Franz-Xaver Scherl, Waltraud Simsch, Adelgunde Oberhauser
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Patent number: 8013179Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formulas: and wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also disclosed.Type: GrantFiled: May 22, 2009Date of Patent: September 6, 2011Assignee: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Publication number: 20110207703Abstract: Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.Type: ApplicationFiled: November 5, 2009Publication date: August 25, 2011Applicant: Vascular Biogenics Ltd.Inventors: Eti Kovalevski-Ishai, Zeev Ziniuk, Gideon Halperin, Itzhak Mendel, Erez Feige, Niva Yacov, Eyal Breitbart
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Publication number: 20110105439Abstract: Provided are a drug, a cosmetic, etc. for promoting production of ceramide. Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.Type: ApplicationFiled: July 30, 2009Publication date: May 5, 2011Applicant: Kao CorporationInventors: Yoshiya Sugai, Hiroshi Hashimoto, Shinya Amano, Shotaro Ito, Yoshie Shimotoyodome, Yoriko Nakagiri
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Patent number: 7867385Abstract: Compositions and methods are provided for separating bitumen from oil sands in an efficient and environmentally acceptable manner, and for recovering residual bitumen from existing tailings ponds.Type: GrantFiled: April 23, 2010Date of Patent: January 11, 2011Assignee: Vary Petrochem, LLCInventors: Robert C Yeggy, Vito J Altavilla
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Publication number: 20110003010Abstract: Phosphoric esters comprise A) one or more structural units derived from substances of component a), the substances of component a) being selected from orthophosphoric acid and one or more of its derivatives, B) one or more structural units derived from substances of component b), the substances of component b) being selected from one or more compounds of formula (I) R2—O—(CH2CH2O)u(C3H6O)v(DO)w—H??(I) and C) one or more structural units derived from substances of component c), the substances of component c) being selected from one or more diols of formula (II) HO—(CH2CH2O)a(C3H6O)b(DO)c—H??(II) where the sum total a+b+c is ?1 and the phosphoric ester contains 2 or more phosphorus atoms per molecule which are bridged via a structural unit derived from the compounds of formula (II). The phosphoric esters of the invention are very useful in the manufacture of cosmetic, pharmaceutical and dermatological compositions.Type: ApplicationFiled: July 29, 2008Publication date: January 6, 2011Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Peter Klug, Franz-Xaver Scherl, Waltraud Simsch, Adelgunde Oberhauser
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Patent number: 7862709Abstract: Compositions and methods are provided for separating bitumen from oil sands in an efficient and environmentally acceptable manner, and for recovering residual bitumen from existing tailings ponds.Type: GrantFiled: April 23, 2010Date of Patent: January 4, 2011Assignee: Vary Petrochem, LLCInventors: Robert C Yeggy, Vito J Altavilla
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Publication number: 20100316579Abstract: The use of an oral care composition comprising certain alkyl phosphates is described for combating dental erosion and tooth wear.Type: ApplicationFiled: October 25, 2007Publication date: December 16, 2010Inventors: Christabel Fowler, Gareth David Rees
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Publication number: 20100228045Abstract: The present invention relates to a suspension stabilizer for dispersing inorganic nanoparticles into aqueous medium. More particularly, the present invention is directed to a biocompatible suspension stabilizer which comprises phosphoryl domain having an affinity to the surface of an inorganic nanoparticle and poly(ethylene glycol) having an affinity to the aqueous medium, and which is prepared by reacting a biocompatible poly(ethylene glycol)-derivatized polymer with phosphine oxide having a leaving group.Type: ApplicationFiled: October 15, 2008Publication date: September 9, 2010Applicant: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATIONInventors: Taeghwan Hyeon, Sang-Wook Kim, Hyon-Bin Na
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Patent number: 7785462Abstract: Compositions and methods are provided for separating bitumen from oil sands in an efficient and environmentally acceptable manner, and for recovering residual bitumen from existing tailings ponds.Type: GrantFiled: April 16, 2010Date of Patent: August 31, 2010Assignee: VARY Petrochem, LLCInventors: Robert C Yeggy, Vita J Altavilla
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Patent number: 7777066Abstract: The present invention provides a chemically stable and novel glycero-compound having one or two triple bonds, one molecule of a glycerol and one or two molecules of a fatty alcohol having a triple bond being linked through an ether bond, an organic group being linked to residual hydroxyl groups of the glycerol, which can be used as a membrane material for forming a vesicle membrane due to its high intermolecular cohesive force, and also provides a membrane forming material containing the same. The glycero-compound has a triple bond represented by the following general formula (1): wherein n and m each represents a number of 1 to 17 and the total (n+m) is a number of 4 to 18, n and m may be the same or different, and R represents a hydrogen atom, a metal atom, a phosphoric acid group, or an organic group which may be linked through a phosphoric acid group.Type: GrantFiled: November 2, 2006Date of Patent: August 17, 2010Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Teruhiko Baba, Toshiyuki Takagi, Toshiyuki Kanamori
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Publication number: 20100160645Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.Type: ApplicationFiled: May 29, 2009Publication date: June 24, 2010Applicant: Intezyne Technologies, Inc.Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
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Publication number: 20100055164Abstract: The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.Type: ApplicationFiled: July 20, 2007Publication date: March 4, 2010Applicants: UNIVERSITY OF ROCHESTER, UNIVERSITY OF GUELPHInventors: Robert H. Notter, Zhengdong Wang, Adrian L. Schwan, Zhongyi Wang, Jason A. Davy, Alan J. Waring, Frans Walther, Larry M. Gordon
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Publication number: 20100016485Abstract: Disclosed are latex polymers and an aqueous coating compositions having excellent freeze-thaw stability, open time, stain resistance, low temperature film formation, foam resistance, block resistance, adhesion, water sensitivity and a low-VOC content. The latex polymers and aqueous coating compositions include at least one latex polymer derived from at least one monomer copolymerized or blended with an alkoxylated compound, for example an alkoxylated tristyrylphenol or an alkoxylated tributylphenol. Also provided is an aqueous coating composition including at least one latex polymer, at least one pigment, water and at least one freeze-thaw additive. Typically, the freeze-thaw additive in an amount greater than about 1.3% by weight of the polymer, typically in an amount greater than about 2% by weight of the polymer, in an amount greater than about 4% by weight of the polymer, in an amount greater than about 7.Type: ApplicationFiled: September 23, 2009Publication date: January 21, 2010Applicant: RHODIA INC.Inventors: Zhengang Zong, Yi-Zhong Li, Jose Ruiz
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Publication number: 20090203556Abstract: Phosphate esters useful for gelling hydrocarbons in combination with a metal source are disclosed along with methods of preparation of the phosphate esters. Fouling in oil refinery towers has been attributed due to distillation of impurities present in phosphate esters used to gel hydrocarbons for oil well fracturing. The improved method of preparation of the phosphate ester results in a product that substantially reduces or eliminates volatile phosphorus, which is phosphorus impurities that distill up to 250° C., and increases the high temperature viscosity of the hydrocarbon gels formed using the phosphate esters.Type: ApplicationFiled: February 9, 2009Publication date: August 13, 2009Applicant: BRINE-ADD FLUIDS LTD.Inventors: IOAN GHESNER, DAVID P. HORTON
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Patent number: 7476700Abstract: The invention relates to organophosphorus compounds comprising a polysulfide bridge, to their process of preparation and to their use as coupling agent between an inorganic or metal filler and an elastomer. The compounds correspond to the formula (I) (RO)2?tR1tP(O)—Ox—(CH2)y—Sz—(CH2)y—Ox—P(O) (OR)2?tR1t in which R represents a hydrogen , an alkyl, an aryl, a trialkylsilyl, a trialkylamino or an alkali metal; R1 represents an alkyl or an aryl; x is 0 or 1; y is an integer from 1 to 22, preferably from 2 to 4; z is equal or larger than 3, t is 0 or 1.Type: GrantFiled: July 7, 2003Date of Patent: January 13, 2009Assignees: Centre National de la Recherche Scientifique, Universite Montpellier II Sciences et Techniques du LanguedocInventor: Hubert Mutin
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Patent number: 7378403Abstract: Disclosed are inhibitors of the serine/threonine kinase Akt, pharmaceutical compositions comprising such inhibitors, and a method of preventing or treating a disease or condition in an animal by the use of such inhibitors.Type: GrantFiled: September 3, 2003Date of Patent: May 27, 2008Assignees: The United States of America as represented by the Department of Health and Human Services, Georgetown UniversityInventors: Alan P. Kozikowski, Phillip Dennis, Haiying Sun, John Brognard
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Publication number: 20040106728Abstract: New compounds, compositions and methods which find application in solid phase synthesis including the preparation of high-density arrays of diverse polymer sequences such as diverse peptides and oligonucleotides as well as in preparation of arrays of small ligand molecules. The compounds of the present invention are those which are typically referred to as linking groups, linkers or spacers and include unsymmetrical disulfide linking groups, and 1,3-diol derivatives capable of providing a triggered release of an attached compound from a solid support under mild conditions. Additional new compounds are labels which can be incorporated into either the 3′ or 5′ terminus of a DNA oligomer.Type: ApplicationFiled: July 14, 2003Publication date: June 3, 2004Applicant: Affymetrix, Inc.Inventors: Glenn H. McGall, Anthony D. Barone, Martin Diggelmann
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Patent number: 6653296Abstract: Resolved enantiomers of the formula (IA) and (IB) wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.Type: GrantFiled: February 2, 1995Date of Patent: November 25, 2003Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.Inventors: Antonin Holy, Hana Dvorakova, Erik Desire Alice De Clercq, Jan Marie Rene Balzarini
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Patent number: 6541428Abstract: The invention concerns alkoxylated sulfur alcohol orthophosphate compositions. It also concerns a method for preparing said compositions by sulphurizing alcohol orthophosphate composition. It further concerns the use of said alkoxylated sulphur alcohol orthophosphate compositions as multifunctional additives in lubricating or detergent aqueous formulations.Type: GrantFiled: March 5, 2001Date of Patent: April 1, 2003Assignee: Rhodia ChimieInventor: Jean-Luc Joye
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Patent number: 6500917Abstract: The invention provides an improved process for the synthesis of compounds carrying at least one phosphate group, especially polyalkylene glycol phosphate compounds, said process comprising the steps of: (a) reacting a compound containing at least one primary alcohol moiety with a diaryl- or diaralkyl-halophosphate whereby to form the corresponding diaryl- or diaralkyl-phosphate ester; (b) reductively cleaving the resulting product; and (c) if desired, repeating steps (a) and (b) with the product of step (b) whereby to produce a compound carrying two or more phosphate groups. Advantages of the process in accordance with the invention are that this avoids the production of by-products and results in products which are low in impurities. Also provided are novel diaryl- and diaralkyl-phosphate ester compounds, in particular polyethylene glycol diphenylphosphate ester and derivatives thereof.Type: GrantFiled: January 24, 2000Date of Patent: December 31, 2002Assignee: Amersham Health ASInventors: Manohar Tukaram Saindane, David Lee Ladd
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Patent number: 6423130Abstract: The invention relates to phosphoric esters of the general formula I where X is 1 or 2; n is from 2 to 18; m and o are each from 2 to 100; k is from 2 to 4; R″ is H or a linear or branched alkyl radical; and R′ is an alkyl, alkaryl, alkenyl, or sulfopropyl radical, and to there use as dispersants for pigments and fillers in aqueous or organic media.Type: GrantFiled: April 10, 2001Date of Patent: July 23, 2002Assignee: Th. Goldschmidt AGInventors: Tammo Boinowitz, Eberhard Esselborn, Arno Knebelkamp, Christian Psiorz, Stefan Silber, Stefan Stadtmüller, Ellen Wallhorn
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Patent number: 6384260Abstract: This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates and methods for the preparation of these analogues. The analogues are useful as research reagents in biomedical studies related to structure, function and therapeuticals, including reference materials for analyzing the metabolic products in safety and efficacy studies of 2- and/or 3-hydroxyl modified inositols and phosphatidylinositols as drug candidates.Type: GrantFiled: April 3, 2001Date of Patent: May 7, 2002Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 6376697Abstract: The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses, and novel key intermediates of synthesis; the novel methods of synthesis are applied also for the preparation of the phosphoinositides in non-labelled form. In addition, the present invention discloses a class of novel compounds as isotope labelled key precursors of labelled phosphoinositides. These precursors are derivatives of the target phosphoinositides, labelled with stable or radioactive isotopes, wherein OH and phosphate groups are blocked with temporary protecting groups.Type: GrantFiled: April 15, 1999Date of Patent: April 23, 2002Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Publication number: 20020010102Abstract: New sulfur-containing organophosphorus compounds of general formulae (I) and (II) and processes for producing the same; additives for lubricating oils, which contain the sulfur-containing organophosphorus compounds; and lubricating oil compositions satisfying requirements of extreme-pressure lubrication and abrasion resistance under severe conditions of high loads imposed, on automatic or continuously variable transmissions or the like. In said formulae, R1 is a hydrocarbon group having 6 to 20 carbon atoms; R2 is a divalent hydrocarbon group having 1 to 6 carbon atoms; n is an integer of 1 to 3; p is an integer of 0 to 2; and q is an integer of 0 or 1, with the proviso that p and q cannot be 0 at the same time.Type: ApplicationFiled: April 4, 2000Publication date: January 24, 2002Inventors: HIROAKI KOSHIMA, HITOSHI HATA, NOBORU SONODA, IZUMI TERADA
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Patent number: RE39746Abstract: The invention relates to phosphoric esters of the general formula I where X is 1 or 2; n is from 2 to 18; m and o are each from 2 to 100; k is from 2 to 4; R? is H or a linear or branched alkyl radical; and R? is an alkyl, alkaryl, alkenyl, or sulfopropyl radical, and to there use as dispersants for pigments and fillers in aqueous or organic media.Type: GrantFiled: May 25, 2004Date of Patent: July 31, 2007Assignee: Goldschmidt GmbHInventors: Tammo Boinowitz, Eberhard Esselborn, Arno Knebelkamp, Christian Psiorz, Stefan Silber, Stefan Stadtmüller, Ellen Wallhorn