Chalcogen Attached Indirectly To The Phosphorus By Nonionic Bonding Patents (Class 558/194)
  • Publication number: 20130035451
    Abstract: Disclosed are phosphinic acid compounds of formula I, II or III where R1 and R1? are for instance straight or branched C1-C50alkyl, R2 is for instance straight or branched C22-C50alkyl, R3 and R3? are for instance straight or branched C1-C50alkyl, R4 is for instance straight or branched C1-C50alkylene and m is from 2 to 100. Also disclosed are polyester compositions comprising the compounds of formula I, II and III.
    Type: Application
    Filed: August 7, 2012
    Publication date: February 7, 2013
    Inventors: Paul Odorisio, Stephen M. Andrews, Thomas F. Thompson, Si Wu, Paragkumar Thanki, Deepak M. Rane, Delina Joseph, Jianzhao Wang
  • Publication number: 20120322769
    Abstract: A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.
    Type: Application
    Filed: February 16, 2011
    Publication date: December 20, 2012
    Applicants: DUKE UNIVERSITY, UWM RESEARCH FOUNDATION
    Inventors: Ching-Hong Yang, Xin Chen, Eric J. Toone
  • Publication number: 20110172194
    Abstract: This invention relates to a composition that comprises inositol phosphates and/or bisphosphonates, and to the use thereof to prevent the loss of substances of biological interest in the body of patients subjected to dialysis and to maintain sufficient physiological levels of said substances to regulate physiological and/or pathological processes, these substances being inhibitors of pathological crystallisation.
    Type: Application
    Filed: May 14, 2009
    Publication date: July 14, 2011
    Inventors: Félix Grases Freixedas, Joan Perello Bestard, Fernando Tur Espinosa, Antonia Costa Bauza, Rafael M. Prieto Almirall, Isabel Gomila Muñiz
  • Publication number: 20110046408
    Abstract: Phosphate esters useful for gelling hydrocarbons in combination with a metal source are disclosed along with methods of preparation of the phosphate esters. Fouling in oil refinery towers has been attributed due to distillation of impurities present in phosphate esters used to gel hydrocarbons for oil well fracturing. The improved method of preparation of the phosphate ester results in a product that substantially reduces or eliminates volatile phosphorus, which is phosphorus impurities that distill up to 250° C., and increases the high temperature viscosity of the hydrocarbon gels formed using the phosphate esters.
    Type: Application
    Filed: November 5, 2010
    Publication date: February 24, 2011
    Applicant: BRINE-ADD FLUIDS LTD.
    Inventors: IOAN GHESNER, DAVID P. HORTON
  • Patent number: 7659262
    Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: February 9, 2010
    Assignee: Bristol-Myers Squibb Co.
    Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
  • Patent number: 7659261
    Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: February 9, 2010
    Assignee: Bristol-Myers Squibb Co.
    Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
  • Patent number: 7572778
    Abstract: The present invention is related to new derivatives of Combretastatin, of Formula obtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on olefinic bound; ii) replace an aromatic ring in a natural product with an amino-aromatic ring. Said compounds recognize and bind the tubulin site: are useful for treating pathological states which arise from or are exacerbated by cell proliferation—as anticancer and/or antiangiogenic activity, in a mammal—to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: August 11, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Giuseppe Giannini, Domenico Alloatti, Marcella Marcellini, Mauro Marzi, Teresa Riccioni, Maria Ornella Tinti
  • Patent number: 7524832
    Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: April 28, 2009
    Assignee: Bristol-Myers Squibb Co.
    Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
  • Publication number: 20090099061
    Abstract: A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.
    Type: Application
    Filed: May 13, 2008
    Publication date: April 16, 2009
    Inventors: Bente J. Foss, Geoffry T. Nadolski, Samuel F. Lockwood
  • Patent number: 6855702
    Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: February 15, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
  • Publication number: 20040230067
    Abstract: This invention provides antigen substance inductors which produce highly selective and/or specific vaccine precursor, vaccine, antibody (including idiotype antibody), neutralizing antibody, antitoxin.
    Type: Application
    Filed: February 26, 2004
    Publication date: November 18, 2004
    Inventors: Shozo Koyama, Satoshi Tanaka
  • Publication number: 20040225146
    Abstract: Disclosed are 4-(difluoromethylene)phosphonate cinnamic acid derivatives as a molecular scaffold for the preparation of protein tyrosine phosphatase inhibitors. The invention also relates to a process for the combinatorial preparation of protein tyrosine phospatase inhibitors possessing a 4-(difluoromethylene)phosphonate cinnamic acid/ester molecular scaffold.
    Type: Application
    Filed: May 5, 2003
    Publication date: November 11, 2004
    Inventors: Hartmuth C. Kolb, Paul F. Richardson, Ramanaiah C. Kanamarlapudi
  • Publication number: 20040103820
    Abstract: A 2-methoxyphenol derivative and an ink composition containing the 2-methoxyphenol derivative, an aqueous medium, and a colorant enhance light resistance by absorbing ultraviolet (UV) light, provide wettability and stabilize a colorant. The ink composition prepared using the 2-methoxyphenol derivative also has improved light resistance, wettability and stabilizes a colorant and does not require an additional light-resistant agent.
    Type: Application
    Filed: November 12, 2003
    Publication date: June 3, 2004
    Applicant: SAMSUNG Electronics Co., Ltd.
    Inventors: Yeon-Kyoung Jung, Seung-Min Ryu
  • Publication number: 20040019232
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: November 6, 2002
    Publication date: January 29, 2004
    Inventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
  • Patent number: 6670344
    Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: December 30, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
  • Publication number: 20030181424
    Abstract: Compositions for the inhibition of the formation of new vaculature by angiogenesis are provided as in compounds which are salts comprising as an acidic component a compound of formula (1) wherein: R1, R2 and R3 are each independently alkyl, R4 is alkoxy, haloalkoxy, alkyl, haloalkyl, alkenyl, alkynyl, alkylthio, alkylsulphinyl, alkylsulphonyl, hydroxy or halo, R5 is hydrogen, alkoxy, alkyl, alkylthio, hydroxy, phosphate or halo, and, as the basic component, a compound selected from the group consisting of (2) a compound of formula (2) wherein R6 is hydrogen or alkyl R7 is alkyl, alkylamino, dialkylamino, nitroamino, hydrazine, mercapto or alkylthio X is CH2, CH2CH2, CH2S, CH2CH2S Y is NH or S or a compound of formula (3) wherein R8 is alkyl or aminoalkyl R9 is hydrogen, alkyl or optionally substituted phenyl or, a compound of formula (4) wherein Z is 0, S, CH2, CHR13 or a bond R10, R11, R12 and R13 are each independently alkyl or hydrogen or, a compound of formula (5) wherein R14 is alkyl and the pharmaceutic
    Type: Application
    Filed: February 14, 2003
    Publication date: September 25, 2003
    Inventor: Peter David Davis
  • Publication number: 20030130239
    Abstract: The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives.
    Type: Application
    Filed: October 29, 2002
    Publication date: July 10, 2003
    Applicant: Allergan, Inc.
    Inventors: Robert M. Burk, Mark Holoboski, Mari F. Posner
  • Publication number: 20030118523
    Abstract: An adhesive composition is provided which is suitable for the bonding of polymeric materials, in whole or in part, such as composite resins, or methacrylate-containing glass-ionomer filling materials, to tooth enamel, or tooth dentin, or to other hand tissues of the human body, such as bone. The composition comprises an unsaturated carboxylic acid ester, an unsaturated phosphate ester and other crosslinking agents. The especially preferred phosphates (which are provided as new compounds) are those of formula (I) in which: R1 is a hydrogen atom, alkyl C1-C4, or CN; R is an aliphatic, cycloaliphatic or aryl radical containing from 1 to 10 carbon atoms and having a valence of n+1; n is an integer from 1 to 5, preferably from 3 to 5.
    Type: Application
    Filed: January 10, 2003
    Publication date: June 26, 2003
    Applicant: BioMat Sciences, Inc.
    Inventors: Ivan Stangel, Jingwei Xu, Thomas Ellis, Edward Sacher
  • Publication number: 20030100538
    Abstract: This invention pertains to substituted chalcones, specifically substituted 1-(4-methoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-1-en-3-ones, which have therapeutic application, for example, as potent antiproliferative agents and antiinflammatory agents, and which have the formula (I) wherein: X is —H, —OH, —OC(═O)R3, —OS(═O)2OH, or —OP(═O)2(OH)2; Y is —H or a C1-4alkyl group; Z is —H or —OCH3; R1 is —H, a C1-4alkyl group, or C1-4fluoroalkyl group; R2 is —H, a C1-4alkyl group, or C1-4fluoroalkyl group; and, R3 is —H, a C1-6alkyl group, a C3-20 heterocyclyl group, or a C5-20aryl group; and pharmaceutically acceptable salts, esters, and protected forms thereof.
    Type: Application
    Filed: September 26, 2002
    Publication date: May 29, 2003
    Inventors: Gerard Andrew Potter, Paul Crispin Butler, Elugba Wanogho
  • Publication number: 20030008818
    Abstract: The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.
    Type: Application
    Filed: December 19, 2001
    Publication date: January 9, 2003
    Applicant: California Institute of Technology and Insert Therapeutics, Inc
    Inventors: Suzie Hwang Pun, Hector Gonzalez, Mark E. Davis, Nathalie Bellocq, Jianjun Cheng
  • Patent number: 6475347
    Abstract: Disclosed herein are compounds of the structure wherein R1, R2, and R3 are organic radicals of C1 to C20, such that the combination of the three contain at least twelve carbon atoms and R3 is bound to the methylene carbon atom between X and the aromatic ring by at least one saturated carbon atom, allowing it to be easily separated from the polymerizable monomer by distillation; R1 and R2 have sufficient steric bulk to protect the phenol from reacting with an alkoxy group or halogen bound to silicon; and X is a neutral heteroatomic radical of oxygen, nitrogen, or phosphorus; and their use as inhibitors for the polymerization of (meth)acryloxysilanes.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: November 5, 2002
    Assignee: Crompton Corporation
    Inventors: Robert E. Sheridan, Kenneth W. Hartman
  • Patent number: 6403819
    Abstract: A process for the formation of a di(hydroxyalkylaryl) aryl phosphate is disclosed which comprises the reaction of an o-alkyl substituted aromatic diol, e.g., an o-alkyl substituted hydroquinone such as o-t-butylhydro-quinone, and monoaryl dihalophosphate, such as monophenyl dichlorophosphate. This process can, in particular, be used to make certain di(hydroxy-o-alkylphenyl) phenyl phosphate compounds, preferably those that are p-hydroxy, such as di(p-hydroxy-o-t-butylphenyl) phenyl phosphate.
    Type: Grant
    Filed: May 21, 1997
    Date of Patent: June 11, 2002
    Assignee: Akzo Nobel, NV
    Inventors: Danielle A. Bright, Jeffrey E. Telschow
  • Patent number: 6346615
    Abstract: Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T½ kinetics of the chemiluminescent reaction, as well as the signal intensity, or quantum yield of the chemiluminescent reaction, can be altered by selection of an electron-withdrawing or an electron-donating group Z, at positions on the aromatic substituent other than those adjacent the point of attachment to the dioxetane. Signal strength can further be enhanced by recognized chemiluminescent enhancers.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: February 12, 2002
  • Publication number: 20020013294
    Abstract: A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and treat bone disorders.
    Type: Application
    Filed: January 31, 2001
    Publication date: January 31, 2002
    Inventors: Mitchell Anthony DeLong, John McMillan McIver, Robert Scott Youngquist
  • Patent number: 6307085
    Abstract: A process for generation of acid uses a medium comprising a first acid-generating component capable of generating a first acid, and a secondary acid generator, this secondary acid generator being capable of thermal decomposition to form a secondary acid, the thermal decomposition of the secondary acid generator being catalyzed by the first acid. At least part of the medium is exposed to so as to cause formation of the first acid from the first acid-generating component; and the medium is then heated to cause, in the exposed part of the medium, acid-catalyzed thermal decomposition of the secondary acid generator and formation of the secondary acid.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: October 23, 2001
    Assignee: Polaroid Corporation
    Inventors: Jurgen M. Grasshoff, John L. Marshall, Richard A. Minns, Socorro M. Ramos, Stephen G. Stroud, Stephen J. Telfer, Haixin Yang, Roger A. Boggs, Eric S. Kolb
  • Patent number: 6300511
    Abstract: The present invention provides a method of substituting a carbonyl compound with fluorine at the &agr;-position, comprising reaching the carbonyl compound with a fluorinating present of a metal-containing catalyst. The reaction results in replacement of a hydrogen atom by fluorine. The catalyst, which is used in a catalytically effective amount, is preferably a transition metal. In one class of methods the catalyst is a transition metal compound. In another class of methods, the catalyst is an elemental metal, in which case the carbonyl compound has an activating group attached to the carbon atom which is substituted by fluorine.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: October 9, 2001
    Assignee: F2 Chemicals Limited
    Inventors: Richard Dickinson Chambers, John Hutchinson, John Stewart Moilliet
  • Patent number: 6251833
    Abstract: The present invention relates to novel 2-aryl-3-hydroxy-&Dgr;2-cyclopentene-1-one derivatives of the formula (I) in which A, B, D1, D2, G, W, X, Y and Z are each as defined in the description, to processes for their preparation and to their use as herbicides and pesticides.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: June 26, 2001
    Inventors: Christoph Erdelen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Norbert Mencke, Andreas Turberg
  • Patent number: 6184187
    Abstract: Novel phosphorus compounds are effective corrosion inhibitors for perfluoropolyether lubricating oils and greases, and hydraulic fluids.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: February 6, 2001
    Assignee: E. I. duPont de Nemours and Company
    Inventors: Jon L. Howell, Michael A. Hofman
  • Patent number: 6150304
    Abstract: The present invention relates to novel 2-aryl-3-hydroxy-cyclopent-2-en-1-one derivatives of the formula (I) ##STR1## in which X represents halogen, nitro, cyano, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl or halogenoalkoxy,Y represents hydrogen, halogen, nitro, cyano, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl or halogenoalkoxy,Z represents halogen, nitro, cyano, alkyl, alkoxy or halogenoalkoxy andA, B, D.sup.1, D.sup.2, G and n have the meaning given in the description,several processes for their preparation and their use as compositions for controlling pests and as herbicides.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: November 21, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Jacques Dumas, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Hans-Joachim Santel, Markus Dollinger, Andreas Turberg, Norbert Mencke
  • Patent number: 6121222
    Abstract: A novel class of anionic surfactants with improved surfact active properties is comprised of two hydrophilic and two hydrophobic groups represented by the formula: ##STR1## The surfactants exhibit unusually low critical micelle concentration (cmc) and pC-20 values in aqueous media.
    Type: Grant
    Filed: December 27, 1996
    Date of Patent: September 19, 2000
    Assignee: Rhodia Inc.
    Inventors: Ruoxin Li, David James Tracy, Jiang Yang, Manilal S. Dahanayake
  • Patent number: 5958906
    Abstract: Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared from the phospholipid derivatives.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: September 28, 1999
    Assignee: ASTA-Medica Aktiengesellschaft
    Inventors: Gerhard Nossner, Jurij Stekar, deceased, Peter Hilgard, Bernhard Kutscher, Jurgen Engel
  • Patent number: 5840661
    Abstract: The present invention relates to novel 2-aryl-3-hydroxy-cyclopent-2-en-1-one derivatives of the formula (I) ##STR1## in which X represents halogen, nitro, cyano, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl or halogenoalkoxy,Y represents hydrogen, halogen, nitro, cyano, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl or halogenoalkoxy,Z represents halogen, nitro, cyano, alkyl, alkoxy or halogenoalkoxy andA, B, D.sup.1, D.sup.2, G and n have the meaning given in the description,several processes for their preparation and their use as compositions for controlling pests and as herbicides.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: November 24, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Jacques Dumas, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Hans-Joachim Santel, Markus Dollinger, Andreas Turberg, Norbert Mencke
  • Patent number: 5817857
    Abstract: The present invention is a process for forming monohydroxy-terminated aromatic oligomeric phosphates by the reaction of a diaryl halophosphate, such as diphenyl chlorophosphate, optionally in the presence of some monoaryl dihalophosphate, with an aromatic diol, such as resorcinol, to form the monohydroxy-terminated aromatic oligomeric phosphate. The reaction preferably employs a Lewis acid catalyst, such as magnesium dichloride.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: October 6, 1998
    Assignee: Akzo Nobel NV
    Inventors: Danielle A. Bright, Ronald L. Pirrelli
  • Patent number: 5663405
    Abstract: A method of producing an ether-type thio-phospholipid of the formula (I): ##STR1## wherein: n is an integer of 13 to 17;A is C.sub.14 -C.sub.20 acyl group;G is a group selected from the group consisting of: ##STR2## which is useful as synthetic substrate of cytosolic phospholipase A.sub.2 inhibitors, said method being applicable to mass production of the compound (I), intermediates therefor and the preparation of the same are provided.
    Type: Grant
    Filed: September 19, 1995
    Date of Patent: September 2, 1997
    Assignee: Shionogi & Co., Ltd.
    Inventors: Mitsuaki Ohtani, Masahiro Fuji
  • Patent number: 5658897
    Abstract: The present invention relates to cyclopentane (or cyclopentane) heptanoic or cyclopentane (or cyclopentene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl, 1-esters, and derivatives thereof, useful as therapeutic agents. In particular, the therapeutic agents of this invention are useful as ocular hypotensives.
    Type: Grant
    Filed: April 8, 1996
    Date of Patent: August 19, 1997
    Assignee: Allergan
    Inventor: Robert M. Burk
  • Patent number: 5637747
    Abstract: A compound of the formula ##STR1##
    Type: Grant
    Filed: September 22, 1992
    Date of Patent: June 10, 1997
  • Patent number: 5616759
    Abstract: Cyclohexylidene compounds of the structure: ##STR1## where X.sup.1 and X.sup.2, which may be the same or different, is hydrogen or a hydroxy-protecting group, and Y is --POPh.sub.2, or --PO (OAlkyl).sub.2, or --SO.sub.2 Ar, or --Si(Alkyl).sub.3. The compounds are used as intermediates in the preparation of 19-nor-vitamin D compounds.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: April 1, 1997
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Rolf E. Swenson
  • Patent number: 5599975
    Abstract: A compound selected from those of formula (I): ##STR1## wherein A, X, Y, Z, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description.This compound or its physiologically tolerable salts may be used therapeutically as platelet anti-aggregation agent.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: February 4, 1997
    Assignee: Adir Et Compagnie
    Inventors: Ren e Gree, Ali M. Hachem, Danielle Gree, Yves Le Floc'h, Yves Rolland, Serge Simonet, Tony Verbeuren
  • Patent number: 5550277
    Abstract: Perfluoroalkyl and perfluoroalkylether substituted aromatic phosphates, phosphonates and related compositions prepared by reaction of pefluoroalkyl or pefluoroakylether substituted phenols with mono- and dihalophosphite and primary and secondary phosphonyl halides are disclosed. These materials are useful as antioxidant, anticorrosion, antirust, and lubricity enhancing agents for perfluoropolyalkylether fluids.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: August 27, 1996
    Inventors: Kazimiera J. L. Paciorek, Wen-Huey Lin, Steven R. Masuda, James H. Nakahara
  • Patent number: 5405544
    Abstract: Beta-hydroxyalkyl-bis(alkylthiomethylphenyl) dithiophosphate esters represented by the formulas ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each H, a (C.sub.1 -C.sub.40) alkyl group, --CH.sub.2 SR, --C.sub.6 H.sub.5 or --C.sub.6 H.sub.4 --R.sub.5 providing at least one of R.sub.1, R.sub.2 and R.sub.3 is --CH.sub.2 SR; R.sub.4 is H or a (C.sub.1 -C.sub.40) alkyl group; R is H or a (C.sub.1 -C.sub.40) alkyl group, --C.sub.6 H.sub.5 or --C.sub.6 H.sub.4 --R.sub.5 ; and R.sub.5 is a (C.sub.1 -C.sub.40) alkyl group.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: April 11, 1995
    Assignee: Texaco Inc.
    Inventors: Carl K. Esche, Jr., Julian H. Dancy, Doris Love
  • Patent number: 5386017
    Abstract: Novel alkenes leading to light producing 1,2-dioxetanes of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X. X is a chemically labile group which is removed by an activating agent. The 1,2-dioxetane compounds can be triggered to produce light at room temperatures.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: January 31, 1995
    Assignee: Board of Governors of Wayne State University
    Inventor: Arthur P. Schaap
  • Patent number: 5322871
    Abstract: Compounds of the formula I ##STR1## in which x is 1, 2 or 3, and, if x=1, R.sup.1 is C.sub.1 -C.sub.30 alkyl, C.sub.1 -C.sub.18 alkyl substituted by halogen, --COOR.sup.2, --CN, --NR.sup.3 R.sup.4 or by --CONR.sup.3 R.sup.4, C.sub.2 -C.sub.18 alkyl which is interrupted by --NR.sup.5 --, --O-- or --S--, C.sub.3 -C.sub.18 alkenyl, C.sub.5 -C.sub.12 cycloalkyl, phenyl-C.sub.1 -C.sub.4 alkyl, phenyl which is unsubstituted or substituted by C.sub.1 -C.sub.12 alkyl, halogen, phenyl-C.sub.1 -C.sub.4 alkyl and/or C.sub.1 -C.sub.4 alkoxy, or R.sub.1 is naphthyl, a radical of the formula ##STR2## R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of one another, are hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.12 cycloalkyl or phenyl-C.sub.1 -C.sub.4 alkyl, R.sup.6 is hydrogen, methyl, allyl or benzyl, R.sup.7 is hydrogen or --OR.sup.9, R.sup.8 is hydrogen or methyl, R.sup.9 is hydrogen or C.sub.1 -C.sub.30 alkyl, R.sup.10 and R.sup.11, independently of one another, are hydrogen or C.sub.1 -C.sub.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: June 21, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Rita Pitteloud, Peter Hofmann, Rudolf Maul, Volker Schenk, Eduard Troxler, Horst Zinke
  • Patent number: 5306841
    Abstract: A compound having the formula ##STR1## where X is a radical of myo-inositol or a radical of a configuration isomer thereof where at least one R is ##STR2## where Y is (1) oxygen, (2) a straight or branched alkyl with 1-10 carbon atoms, where Z is ##STR3## where A.sup.1 and A.sup.2 are the same or different and are hydrogen or methyl and n is 3-10, or ##STR4## where A.sup.1 and A.sup.2 are hydrogen or methyl and where m is 1-5, where R.sup.1 is hydrogen, straight or branched alkyl, aryl or alkaryl, alkoxy or aryloxy, where R.sup.2 is(1) R.sup.1,(2) hydroxyl, or(3) OZOCOR.sup.1,and where the remaining R is/are hydroxyl.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: April 26, 1994
    Inventors: Hans Bundgaard, deceased, by Charlotte Bundgaard, legal representative
  • Patent number: 5298500
    Abstract: Disclosed is a phosphoric acid ester derivative represented by the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each lower alkyl, X.sup.1 and X.sup.2 are the same or different and are each a hydrogen atom or halogen atom, and Y is an oxygen atom or sulfur atom. The phosphoric acid ester derivatives of the present invention are usable as insecticides and miticides having excellent residual activity and low toxicity to warm blooded animals.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: March 29, 1994
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventor: Hisashi Takao
  • Patent number: 5260051
    Abstract: The invention relates to novel compositions, in particular personal product compositions containing phosphate ester surfactants in which a portion of the surfactant molecule has a so-called "benefit reagent" function. It is believed that this benefit reagent portion comes to play when the surfactant is metabolized or hydrolyzed.
    Type: Grant
    Filed: December 17, 1990
    Date of Patent: November 9, 1993
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventor: Suk H. Cho
  • Patent number: 5258540
    Abstract: Compounds of formula Ia ##STR1## in which R.sub.1 is hydrogen, R.sub.2 is methyl, tert-butyl or cyclohexyl, and R.sub.7 and R.sub.8 independently of one another are C.sub.1 -C.sub.18 alkyl, phenyl or C.sub.7 -C.sub.18 alkylphenyl are novel compounds having utility as stabilizers.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: November 2, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Paul Dubs, Werner Stegmann, Reto Luisoli, Roger Martin
  • Patent number: 5254709
    Abstract: A new process is disclosed for the manufacture of hindered aryl phosphites using derivatives of mercaptothiazole or dithiocarbamic acid as catalysts. Ortho-tertiary alkyl aryl phosphites are produced by the reaction of a phosphorus trihalide with an ortho-tertiary alkyl phenolic compound in the presence of the aforementioned catalysts.
    Type: Grant
    Filed: August 24, 1992
    Date of Patent: October 19, 1993
    Assignee: Uniroyal Chemical Company, Inc.
    Inventor: Bryon A. Hunter
  • Patent number: 5232836
    Abstract: Vitamin D derivatives corresponding to the following formula I ##STR1## in which R.sub.1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D.sub.2 (C.sup.20 to C.sup.28) or D.sub.3 (C.sup.20 to C.sup.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: August 3, 1993
    Assignee: Ire-Medgenix S.A.
    Inventors: Roger Bouillon, Pierre J. De Clerco, Pierre Eliard, Maurits Vanderwalle
  • Patent number: 5210263
    Abstract: The present invention provides novel inositol phosphate analogs and a method for their use for detecting the phosphatidylinositol cycle-dependent calcium of a cell.
    Type: Grant
    Filed: May 15, 1990
    Date of Patent: May 11, 1993
    Assignees: University of Pittsburgh, Mayo Foundation For Medical Education and Research
    Inventors: Alan P. Kozikowski, Garth Powis
  • Patent number: 5177241
    Abstract: Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C.sub.1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a compound having the formula: ##STR2## with an R-ylating agent (e.g., R.sub.2 SO.sub.4) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: ##STR3## are produced by reacting a compound having the formula: ##STR4## wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula ##STR5## are produced by reacting a compound of the formula ##STR6## with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups.
    Type: Grant
    Filed: June 14, 1990
    Date of Patent: January 5, 1993