Nitrogen Or Halogen Attached Directly To The Phosphorus By Nonionic Bonding Patents (Class 558/195)
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Publication number: 20150080597Abstract: The present invention is directed to fluorophosphates, and pharmaceutical compositions thereof, which are inhibitors of intestinal apical sodium/phosphate co-transport and are useful in the treatment of hyperphosphatemia, in reducing blood phosphate levels, and in treating hypertension.Type: ApplicationFiled: November 25, 2014Publication date: March 19, 2015Inventors: Brian Peerce, Larry Slomowitz
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Patent number: 8921343Abstract: The present invention is directed to fluorophosphates, and pharmaceutical compositions thereof, which are inhibitors of intestinal apical sodium/phosphate co-transport and are useful in the treatment of hyperphosphatemia, in reducing blood phosphate levels, and in treating hypertension.Type: GrantFiled: March 4, 2011Date of Patent: December 30, 2014Assignee: DuophosInventors: Brian Peerce, Larry Slomowitz
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Publication number: 20130059822Abstract: The present invention is directed to fluorophosphates, and pharmaceutical compositions thereof, which are inhibitors of intestinal apical sodium/phosphate co-transport and are useful in the treatment of hyperphosphatemia, in reducing blood phosphate levels, and in treating hypertension.Type: ApplicationFiled: March 4, 2011Publication date: March 7, 2013Applicant: DUOPHOSInventors: Brian Peerce, Slomowitz Larry
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Publication number: 20130030209Abstract: Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst.Type: ApplicationFiled: September 26, 2012Publication date: January 31, 2013Applicant: IDENIX PHARMACEUTICALS, INC.Inventors: Christophe Claude Parsy, Francois-Rene Alexandre, Florence Marie-Emilie Bonnaterre, Dominique Surleraux
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Patent number: 6506739Abstract: Bis-(N,N′-bis-(2-haloethyl)amino)phosphoramidates, pharmaceutical compositions containing them, methods of treatment using them, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti-tumor activities; and this invention relates to the use of the compounds in methods for the treatment of tumors and, especially, for the treatment of cancer.Type: GrantFiled: May 1, 2001Date of Patent: January 14, 2003Assignee: Telik, Inc.Inventors: R. Jason Herr, Robert T. Lum, Steven R. Schow, Fanying Meng, Michael R. Kozlowski, Pavel Zhichkin
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Patent number: 6184187Abstract: Novel phosphorus compounds are effective corrosion inhibitors for perfluoropolyether lubricating oils and greases, and hydraulic fluids.Type: GrantFiled: April 7, 1998Date of Patent: February 6, 2001Assignee: E. I. duPont de Nemours and CompanyInventors: Jon L. Howell, Michael A. Hofman
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Patent number: 5807846Abstract: The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar.sup.1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl;X is --NH--, --O--, --S--, or --(CH.sub.2).sub.0-4 --, andR is hydrogen, alkyl, or phenyl.Type: GrantFiled: June 24, 1997Date of Patent: September 15, 1998Assignee: Warner-Lambert CompanyInventors: William Howard Roark, Bruce David Roth
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Patent number: 5658897Abstract: The present invention relates to cyclopentane (or cyclopentane) heptanoic or cyclopentane (or cyclopentene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl, 1-esters, and derivatives thereof, useful as therapeutic agents. In particular, the therapeutic agents of this invention are useful as ocular hypotensives.Type: GrantFiled: April 8, 1996Date of Patent: August 19, 1997Assignee: AllerganInventor: Robert M. Burk
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Patent number: 5637747Abstract: A compound of the formula ##STR1##Type: GrantFiled: September 22, 1992Date of Patent: June 10, 1997
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Patent number: 5550276Abstract: Compounds of the general formula I ##STR1## in which n is 1, 2 or 3 and in which X is oxygen or sulfur, T has the meaning of --S--, --S--S--, --S--S--, --S--S--S--S--, --S--S--S--S--S--, ##STR2## and Y has the meaning of ##STR3## in which Z has the meaning of --H, --COR.sup.13, --COOR.sup.13 or --CONHR.sup.13, and Q has the meaning of oxygen or --NR.sup.0 --, and R.sup.1, R.sup.2, R.sup.0, R.sup.4 and R.sup.13 are as defined in claim 1, with the proviso that the compound of the formula C.sub.2 H.sub.5 --S--CH.sub.2 CH(OH)--P(OC.sub.2 H.sub.5).sub.2 is excepted.The invention also relates to compositions containing the compounds of the formula I and organic materials, for example functional liquids and, in particular, lubricants.Type: GrantFiled: June 7, 1995Date of Patent: August 27, 1996Assignee: Ciba-Geigy CorporationInventors: Hermann O. Wirth, Hans-Helmut Friedrich, Kay S. Groninger
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Patent number: 5266552Abstract: Novel herbicides have the formula ##STR1## in which R is halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylcarbamoyl, C.sub.1 -C.sub.4 mono- or dialkylamino, phenoxy or nitro;n is 0, 1 or 2;X is oxygen or sulfur;R.sub.1 is C.sub.2 -C.sub.8 alkyl, C.sub.3 -C.sub.6 cycloalkyl, phenyl, 2-trifluoromethylphenyl, 3-trifluoromethoxyphenyl, 4-methoxyphenyl, 4-nitrophenyl, 3,4-dichlorophenyl or benzyl;R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, phenyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 alkynyl; andR.sub.3 is C.sub.2 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, phenyl, phenyl(C.sub.1 -C.sub.2)-alkyl, 3,4-methylenedioxyphenyl or pyridyl; orR.sub.2 and R.sub.3 taken together with the nitrogen atom form a 4-7 member ring;provided that:a) if X is sulfur, R.sub.2 is not hydrogen;b) if R.sub.2 is hydrogen, R.sub.3 is alkyl, cycloalkyl or phenylalkyl.Type: GrantFiled: November 12, 1991Date of Patent: November 30, 1993Assignee: Imperial Chemical Industries PLCInventors: Michael D. Broadhurst, Harry Tilles
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Patent number: 5205852Abstract: Herbicidal compounds have the formula ##STR1## in which R is C.sub.3 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl;X is oxygen or sulfur;R.sub.1 is C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.6 cycloalkyl optionally substituted with up to two C.sub.1 -C.sub.3 alkyl groups, phenyl, or substituted phenyl having from 1 to 2 substituents selected from halo, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 thioalkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxycarbonyl, and phenyl;R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl; andR.sub.3 is C.sub.2 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, phenyl or substituted phenyl having from 1 to 2 substituents selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl and halogen;provided that if R.sub.2 is hydrogen, R.sub.3 is not phenyl or substituted phenyl;or R.sub.2 and R.sub.3 taken together with the nitrogen atom form a 4-8 membered ring, optionally including an oxygen heteroatom.Type: GrantFiled: November 12, 1991Date of Patent: April 27, 1993Assignee: Imperial Chemical Industries PLCInventors: Michael D. Broadhurst, Tsze H. Tsang
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Patent number: 5189169Abstract: Herbicides having the formula ##STR1## in which X is oxygen or sulfur; and if X is sulfur, R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.6 cycloalkyl, allyl, phenyl, tolyl, chlorophenyl, 3,4-dichlorophenyl, or phen-(C.sub.1 -C.sub.2)alkyl; R.sub.2 is C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkoxyalkyl, or allyl; R.sub.3 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxyalkyl, pyridyl, phenyl or substituted phenyl in which the substituents are halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, nitro and/or cyano; or R.sub.2 and R.sub.3 taken together form an alkylene chain having from 2 to 6 carbon atoms optionally substituted by up to two C.sub.1 -C.sub.4 alkyl groups; if R.sub.3 is alkyl or alkoxyalkyl, then R.sub.4 and R.sub.5 are each C.sub.2 -C.sub.4 alkyl; if R.sub.3 is phenyl, substituted phenyl or pyridyl, then R.sub.4 and R.sub.5 are C.sub.2 -C.sub. 6 alkyl, phenyl or substituted phenyl; or R.sub.3 and R.sub.Type: GrantFiled: November 12, 1991Date of Patent: February 23, 1993Assignee: Imperial Chemical Industries PLCInventor: David B. Kanne
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Patent number: 4962192Abstract: Novel light producing 1,2-dioxetanes are described of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X. X is a chemically labile group which is removed by an activating agent. The 1,2-dioxetane compounds can be triggered to produce light at room temperatures. The compounds are produced from novel alkenes.Type: GrantFiled: December 29, 1988Date of Patent: October 9, 1990Assignee: Board of Governors of Wayne State UniversityInventor: Arthur P. Schaap
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Patent number: 4912155Abstract: Organic materials normally subject to gradual degradation in the presence of oxygen are stabilized by inclusion of an aromatic fluorophosphite having at least one benzene group bonded through oxygen to phosphorus and at least one fluorine atom bonded directly to the same phosphorus. Stabilization is improved by also including a conventional phenolic antioxidant. Many of the aromatic fluorophosphites are new compounds.Type: GrantFiled: February 27, 1987Date of Patent: March 27, 1990Assignee: Ethyl CorporationInventor: Lester P. J. Burton
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Patent number: 4804654Abstract: Compounds of the formula ##STR1## wherein the symbols have assigned meanings, and their use as insecticides and/or miticides.Type: GrantFiled: March 4, 1987Date of Patent: February 14, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mohamed A. H. Fahmy
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Patent number: 4797391Abstract: The invention relates to novel [(5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydro-fluoren-7-yl)o xy]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.Type: GrantFiled: February 8, 1988Date of Patent: January 10, 1989Assignee: Merck & Co., Inc.Inventors: Otto W. Woltersdorf, Jr., Edward J. Cragoe, Jr., Adolph M. Pietruszkiewicz
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Patent number: 4581350Abstract: The invention relates to new organic phosphoric acid esters represented by the general formula ##STR1## wherein X represents O, S or NH,Y represents O or S,R.sup.1 represents a lower alkyl group,R.sup.2 represents a lower alkyl group or a lower alkoxy-lower alkyl group,R.sup.3 represents a fluoro-substituted lower alkyl group,Z represents a lower alkyl group, a lower alkoxy group or a halogen atom, andn represents 0 or 2,which can be used as pesticidally active agents.Type: GrantFiled: May 18, 1984Date of Patent: April 8, 1986Assignee: Nihon Tokushu Noyaku Seizo K.K.Inventors: Junichi Saito, Akio Kudamatsu, Toyohiko Kume, Shinichi Tsuboi
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Patent number: 4576935Abstract: Dihalovinylphenyl phosphates of the formula I ##STR1## where A and B are each halogen or trihaloalkyl, X is oxygen or sulfur, Y and Z are each oxygen, sulfur or --NH--, R.sup.1 is alkyl, R.sup.2 is alkyl, haloalkyl, alkoxyalkyl or alkylthioalkyl, and R.sup.3, R.sup.4 and R.sup.5 independently of one another are each hydrogen, halogen, nitro, alkyl, cyano, alkoxy, alkoxyalkoxy, alkylthioalkylthio, alkoxyalkyl, alkylthioalkyl, alkylthio, trihaloalkyl or trihaloalkoxy, and pesticides containing these compounds.Type: GrantFiled: October 24, 1983Date of Patent: March 18, 1986Assignee: BASF AktiengesellschaftInventors: Gerd-Ulrich Schwarz, Heinrich Adolphi
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Patent number: RE36128Abstract: Organic materials normally subject to gradual degradation in the presence of oxygen are stabilized by inclusion of an aromatic fluorophosphite having at least one benzene group bonded through oxygen to phosphorus and at least one fluorine atom bonded directly to the same phosphorus. Stabilization is improved by also including a conventional phenolic antioxidant. Many of the aromatic fluorophosphites are new compounds.Type: GrantFiled: June 13, 1991Date of Patent: March 2, 1999Assignee: Albemarle CorporationInventor: Lester P. J. Burton