Alicyclic Ring Bonded Directly To One Of The Chalcogens Patents (Class 558/209)
  • Patent number: 11491129
    Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: November 8, 2022
    Assignee: DIFFUSION PHARMACEUTICALS LLC
    Inventors: John L. Gainer, Robert Murray
  • Patent number: 8686177
    Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: April 1, 2014
    Assignee: RxBio, Inc.
    Inventor: Veeresh Gududuru
  • Publication number: 20080293667
    Abstract: The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the activity of the viral infection.
    Type: Application
    Filed: October 31, 2007
    Publication date: November 27, 2008
    Applicants: Wake Forest University, University of North Carolina
    Inventors: Louis S. Kucera, Susan L. Morris-Natschke, Khalid S. Ishaq
  • Publication number: 20040116729
    Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Application
    Filed: August 25, 2003
    Publication date: June 17, 2004
    Applicant: Diffusion Pharmaceuticals LLC
    Inventors: John L. Gainer, Raymond C. Grabiak
  • Patent number: 6667284
    Abstract: A magnetic recording medium and method for forming the magnetic recording medium are described. The magnetic recording medium includes a magnetic layer formed on a non-magnetic support, and a lubricant layer over the magnetic layer. The lubricant layer includes a compound selected from the group consisting of hydrocarbyl-substituted cyclopentanes, hydrocarbyl-substituted cyclopentenes, hydrocarbyl-substituted cyclopentadienes, and mixtures or derivatives thereof. The lubricant layer also may be used on a magnetic head for reading and writing information on a magnetic recording medium. The magnetic recording medium and the magnetic head may be used to manufacture computer disk drives, compact disk drives, audio equipment, and video equipment.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: December 23, 2003
    Assignee: Pennzoil-Quaker State Company
    Inventors: Selda Gunsel, Clifford Venier, I-Ching Chiu
  • Patent number: 6299887
    Abstract: The present invention discloses phosphoric triesters represented by formula (1): wherein R1 represents C12-C24 alkyl or alkenyl, R2 represents C6-C24 alkyl, alkenyl, or aryl, and R3 represents C1-C6 alkyl, C2-C6 alkenyl, or aryl; external compositions containing the phosphoric triesters; and methods for preparing asymmetric phosphoric triesters. The compositions of the present invention have excellent compatibility with the skin, good sensation during use, and a high degree of safety.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: October 9, 2001
    Assignee: Kao Corporation
    Inventors: Shinji Yano, Takashi Komori, Shinji Ishikawa, Katsumi Kita, Takashi Mizooku
  • Patent number: 6245754
    Abstract: The present invention relates to the preparation and biological activity of 3-deoxy-D-myo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as anti-tumor agents which effectively inhibit the growth of mammalian cells.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: June 12, 2001
    Inventors: Alan P. Kozikowski, Lixin Qioa, Garth Powis
  • Patent number: 5412140
    Abstract: Alkyl glycidol ether/dithiophosphoric acid addition products corresponding to the following general formula:[R.sup.1 ]O[C(H)(H)][C(H)C(H)(H)(OH)(R.sup.4)] (I)in whichR.sup.4 =[(R.sup.2 O)(R.sup.3 O)]P(S)S,R.sup.1 . . . R.sup.3 =alkyl, aryl,a process for the production of the adducts from the corresponding dithiophosphoric acids and glycidol ethers and the use of the addition products as lubricant additives in lubricants based on mineral oils or native oils.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: May 2, 1995
    Assignee: Rhein Chemie Rheinau GmbH
    Inventors: Thomas Dimmig, Gunter Jager, Thomas Petri, Wolfram Radig, Gunther Schilling, Jurgen Braun, Volker Schafer
  • Patent number: 5306840
    Abstract: A process for preparing pure L-alpha-Glycerylphosphoryl-D-Myoinositol and its salts consists of a) preparing the crude Na+ or K+ salt of L-.alpha.-Glycerylphosphoryl-D-Myoinositol, passing an aqueous solution of the salt through an acid resin in H form whereby ion exchange occurs and the acid L-.alpha.-Glycerylphosphoryl-D-Myoinositol is eluted by washing the resin with water. Then the aqueous solution is passed through a basic resin whereby the L-.alpha.-Glycerylphosphoryl-D-Myoinositol is adsorbed on the resin as the anion. The resin is eluted first with a dilute solution of formic, acetic or propionic acid and then eluted with a more concentrated solution of the same acid. The preparation of severals salts is also described.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: April 26, 1994
    Assignee: Euticals S.p.A.
    Inventor: Giovanni Tronconi
  • Patent number: 5228898
    Abstract: This invention relates to substituted bicycloheptadione derivatives with high herbicidal activity which are represented by general formula (I) ##STR1## (where R.sup.1 is a lower alkyl group, a phenyl group which may be substituted, an aralkyl group which may be substituted, or a heterocyclic group which may be substituted;R.sup.2 is, same or different, a halogen, an alkoxy group, an alkylthio group, an alkylsulfonyl group, an alkyl group, an alkoxyalkyl group, or an alkoxylcarbonyl group, and n is 0 to 4;R.sup.3 and R.sup.4 are, same or different, hydrogen or a lower alkyl group).
    Type: Grant
    Filed: February 3, 1992
    Date of Patent: July 20, 1993
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Akiyoshi Ueda, Shigemi Suga, Hiroyuki Adachi, Toshio Aihara, Kazuyuki Tomida, Hideki Yamagishi, Hideo Hosaka
  • Patent number: 5210261
    Abstract: Amine salts of phosphorothioic acids, useful for example in lubricant compositions, are made by forming a mixture of sulphur and an amine, and then adding a phosphite ester. The reaction is controlled by the rate of addition of the ester.
    Type: Grant
    Filed: April 8, 1992
    Date of Patent: May 11, 1993
    Assignee: Ethyl Petroleum Additives, Ltd.
    Inventors: Barrie D. James, Roger Scattergood
  • Patent number: 5173431
    Abstract: A procedure for detecting proteins in fluids (particularly body fluids) which involves contacting such fluid with a composition comprising copper in a form capable of forming a copper/protein complex, a peroxide and a redox indicator which provides a detectable response when oxidized, together with an ionizable phosphate containing compound to prevent interference with the redox indicator from substances present in the fluid.
    Type: Grant
    Filed: October 12, 1991
    Date of Patent: December 22, 1992
    Assignee: Miles Inc.
    Inventors: Michael J. Pugia, Michael Salvati
  • Patent number: 4921526
    Abstract: Substituted benzoyl-bicycloalkyl-1,1,3-diones and related compounds, intermediates therefor, synthesis thereof, and the use of said diones for the control of weeds.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: May 1, 1990
    Assignee: Sandoz Ltd.
    Inventors: Shy-Fuh Lee, Gary W. Luehr, Carol R. Scott, Werner Trueb