Alicyclic Ring Bonded Directly To One Of The Chalcogens Patents (Class 558/209)
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Patent number: 11491129Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.Type: GrantFiled: July 9, 2018Date of Patent: November 8, 2022Assignee: DIFFUSION PHARMACEUTICALS LLCInventors: John L. Gainer, Robert Murray
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Patent number: 8686177Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.Type: GrantFiled: March 3, 2009Date of Patent: April 1, 2014Assignee: RxBio, Inc.Inventor: Veeresh Gududuru
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Publication number: 20080293667Abstract: The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the activity of the viral infection.Type: ApplicationFiled: October 31, 2007Publication date: November 27, 2008Applicants: Wake Forest University, University of North CarolinaInventors: Louis S. Kucera, Susan L. Morris-Natschke, Khalid S. Ishaq
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Publication number: 20040116729Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.Type: ApplicationFiled: August 25, 2003Publication date: June 17, 2004Applicant: Diffusion Pharmaceuticals LLCInventors: John L. Gainer, Raymond C. Grabiak
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Patent number: 6667284Abstract: A magnetic recording medium and method for forming the magnetic recording medium are described. The magnetic recording medium includes a magnetic layer formed on a non-magnetic support, and a lubricant layer over the magnetic layer. The lubricant layer includes a compound selected from the group consisting of hydrocarbyl-substituted cyclopentanes, hydrocarbyl-substituted cyclopentenes, hydrocarbyl-substituted cyclopentadienes, and mixtures or derivatives thereof. The lubricant layer also may be used on a magnetic head for reading and writing information on a magnetic recording medium. The magnetic recording medium and the magnetic head may be used to manufacture computer disk drives, compact disk drives, audio equipment, and video equipment.Type: GrantFiled: March 22, 2001Date of Patent: December 23, 2003Assignee: Pennzoil-Quaker State CompanyInventors: Selda Gunsel, Clifford Venier, I-Ching Chiu
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Patent number: 6299887Abstract: The present invention discloses phosphoric triesters represented by formula (1): wherein R1 represents C12-C24 alkyl or alkenyl, R2 represents C6-C24 alkyl, alkenyl, or aryl, and R3 represents C1-C6 alkyl, C2-C6 alkenyl, or aryl; external compositions containing the phosphoric triesters; and methods for preparing asymmetric phosphoric triesters. The compositions of the present invention have excellent compatibility with the skin, good sensation during use, and a high degree of safety.Type: GrantFiled: February 26, 1996Date of Patent: October 9, 2001Assignee: Kao CorporationInventors: Shinji Yano, Takashi Komori, Shinji Ishikawa, Katsumi Kita, Takashi Mizooku
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Patent number: 6245754Abstract: The present invention relates to the preparation and biological activity of 3-deoxy-D-myo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as anti-tumor agents which effectively inhibit the growth of mammalian cells.Type: GrantFiled: June 25, 1999Date of Patent: June 12, 2001Inventors: Alan P. Kozikowski, Lixin Qioa, Garth Powis
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Patent number: 5412140Abstract: Alkyl glycidol ether/dithiophosphoric acid addition products corresponding to the following general formula:[R.sup.1 ]O[C(H)(H)][C(H)C(H)(H)(OH)(R.sup.4)] (I)in whichR.sup.4 =[(R.sup.2 O)(R.sup.3 O)]P(S)S,R.sup.1 . . . R.sup.3 =alkyl, aryl,a process for the production of the adducts from the corresponding dithiophosphoric acids and glycidol ethers and the use of the addition products as lubricant additives in lubricants based on mineral oils or native oils.Type: GrantFiled: December 6, 1993Date of Patent: May 2, 1995Assignee: Rhein Chemie Rheinau GmbHInventors: Thomas Dimmig, Gunter Jager, Thomas Petri, Wolfram Radig, Gunther Schilling, Jurgen Braun, Volker Schafer
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Patent number: 5306840Abstract: A process for preparing pure L-alpha-Glycerylphosphoryl-D-Myoinositol and its salts consists of a) preparing the crude Na+ or K+ salt of L-.alpha.-Glycerylphosphoryl-D-Myoinositol, passing an aqueous solution of the salt through an acid resin in H form whereby ion exchange occurs and the acid L-.alpha.-Glycerylphosphoryl-D-Myoinositol is eluted by washing the resin with water. Then the aqueous solution is passed through a basic resin whereby the L-.alpha.-Glycerylphosphoryl-D-Myoinositol is adsorbed on the resin as the anion. The resin is eluted first with a dilute solution of formic, acetic or propionic acid and then eluted with a more concentrated solution of the same acid. The preparation of severals salts is also described.Type: GrantFiled: August 5, 1992Date of Patent: April 26, 1994Assignee: Euticals S.p.A.Inventor: Giovanni Tronconi
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Patent number: 5228898Abstract: This invention relates to substituted bicycloheptadione derivatives with high herbicidal activity which are represented by general formula (I) ##STR1## (where R.sup.1 is a lower alkyl group, a phenyl group which may be substituted, an aralkyl group which may be substituted, or a heterocyclic group which may be substituted;R.sup.2 is, same or different, a halogen, an alkoxy group, an alkylthio group, an alkylsulfonyl group, an alkyl group, an alkoxyalkyl group, or an alkoxylcarbonyl group, and n is 0 to 4;R.sup.3 and R.sup.4 are, same or different, hydrogen or a lower alkyl group).Type: GrantFiled: February 3, 1992Date of Patent: July 20, 1993Assignee: Nippon Soda Co., Ltd.Inventors: Akiyoshi Ueda, Shigemi Suga, Hiroyuki Adachi, Toshio Aihara, Kazuyuki Tomida, Hideki Yamagishi, Hideo Hosaka
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Patent number: 5210261Abstract: Amine salts of phosphorothioic acids, useful for example in lubricant compositions, are made by forming a mixture of sulphur and an amine, and then adding a phosphite ester. The reaction is controlled by the rate of addition of the ester.Type: GrantFiled: April 8, 1992Date of Patent: May 11, 1993Assignee: Ethyl Petroleum Additives, Ltd.Inventors: Barrie D. James, Roger Scattergood
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Patent number: 5173431Abstract: A procedure for detecting proteins in fluids (particularly body fluids) which involves contacting such fluid with a composition comprising copper in a form capable of forming a copper/protein complex, a peroxide and a redox indicator which provides a detectable response when oxidized, together with an ionizable phosphate containing compound to prevent interference with the redox indicator from substances present in the fluid.Type: GrantFiled: October 12, 1991Date of Patent: December 22, 1992Assignee: Miles Inc.Inventors: Michael J. Pugia, Michael Salvati
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Patent number: 4921526Abstract: Substituted benzoyl-bicycloalkyl-1,1,3-diones and related compounds, intermediates therefor, synthesis thereof, and the use of said diones for the control of weeds.Type: GrantFiled: November 27, 1987Date of Patent: May 1, 1990Assignee: Sandoz Ltd.Inventors: Shy-Fuh Lee, Gary W. Luehr, Carol R. Scott, Werner Trueb