Benzene Ring Bonded Directly To Each Of The Three Chalcogens Patents (Class 558/211)
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Publication number: 20120101015Abstract: Described is a lubricating composition of an anti-wear agent or a combination of anti-wear agents having a reduced neurotoxicity, the anti-wear agent(s) being selected from triaryl phosphate compounds preferably substituted with one or more linear or branched alkyl group(s) including from 2 to 12 carbon atoms.Type: ApplicationFiled: June 23, 2010Publication date: April 26, 2012Applicant: NYCO SAInventors: Pascal Frapin, Issa Latif, Christophe Corbun, Jean-Louis Mansoux
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Patent number: 8143433Abstract: The present invention relates to low triphenyl phosphate, high phosphorous content aryl phosphates with high ortho alkylation that are suitable for use as flame retardant compositions, processes for their preparation, and their use as flame retardants.Type: GrantFiled: April 23, 2007Date of Patent: March 27, 2012Assignee: Albemarle CorporationInventors: William J. Layman, Jr., Arthur G. Mack, Techen Tsao, Jeffrey Todd Aplin, Hoover Chew, Douglas W. Luther
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Patent number: 7659262Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.Type: GrantFiled: March 1, 2006Date of Patent: February 9, 2010Assignee: Bristol-Myers Squibb Co.Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
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Patent number: 7659261Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.Type: GrantFiled: March 1, 2006Date of Patent: February 9, 2010Assignee: Bristol-Myers Squibb Co.Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
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Publication number: 20100004364Abstract: Disclosed herein is a flame retardant and impact modifier represented by the following Chemical Formula 1. The flame retardant and impact modifier may improve heat resistance and flowability as well as flame retardancy and impact strength of a thermoplastic resin composition. The present invention also provides a method of preparing the foregoing flame retardant and impact modifier and a thermoplastic resin composition including the flame retardant and impact modifier.Type: ApplicationFiled: July 2, 2009Publication date: January 7, 2010Applicant: Cheil Industries Inc.Inventors: Min Soo LEE, Beom Jun JOO
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Patent number: 7524832Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.Type: GrantFiled: March 1, 2006Date of Patent: April 28, 2009Assignee: Bristol-Myers Squibb Co.Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
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Patent number: 7365113Abstract: Flavan-based and spirodichroman compound-based phosphate esters prepared by reacting flavans and spirodichroman compounds with phosphorus oxychloride, monophenyl dichlorophosphate, or diphenyl chlorophosphate compounds are described. The flavans and spirodichroman compounds can be synthesized by the reaction of resorcinol with aliphatic acetone. Such phosphate esters can be used as flame retardants.Type: GrantFiled: September 21, 2005Date of Patent: April 29, 2008Inventors: Raj B. Durairaj, Gary A. Jesionowski
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Patent number: 7223747Abstract: The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.Type: GrantFiled: September 24, 2004Date of Patent: May 29, 2007Assignee: Arizona Board of Regents Acting for and on Behalf of Arizona State UniversityInventors: George R. Pettit, Mathew D. Minardi, Heidi J. Rosenberg
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Patent number: 6855702Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.Type: GrantFiled: September 10, 2003Date of Patent: February 15, 2005Assignee: Bristol-Myers Squibb CompanyInventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
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Patent number: 6746732Abstract: Disclosed is a triacetyl cellulose film comprising (a) an unsubstituted triphenyl phosphate compound and (b) a lower alkyl-substituted triphenyl phosphate ester compound. Such a film exhibits a reduced rate of water vapor transmission.Type: GrantFiled: December 13, 2001Date of Patent: June 8, 2004Assignee: Eastman Kodak CompanyInventors: William J. Gamble, Joseph L. Lippert
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Patent number: 6670344Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.Type: GrantFiled: September 11, 2001Date of Patent: December 30, 2003Assignee: Bristol-Myers Squibb CompanyInventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
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Patent number: 6486339Abstract: The isomerization of an alkylated phenol composition that contains an ortho-alkyl substituted phenol component to isomerize and reduce the level of ortho-alkyl substituted phenol component therein can be accomplished by heating that composition in the presence of a catalytically effective amount of a solid acid catalyst to carry out such isomerization and reduction in the level of ortho-alkyl substituted phenol. Examples of suitable solid acid catalysts can be selected from the H-form zeolites, the supported sulfonic acids, and the heteropoly acids. The resulting isomerized product can be subsequently phosphorylated.Type: GrantFiled: April 26, 2001Date of Patent: November 26, 2002Assignee: Akzo Nobel NVInventors: Anantha N. Desikan, George E. Whitwell
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Patent number: 6479688Abstract: A process for the formation of a di(hydroxyalkylaryl) aryl phosphate is disclosed which comprises the reaction of an o-alkyl substituted aromatic diol, e.g., an o-alkyl substituted hydroquinone such as o-t-butylhydro-quinone, and monoaryl dihalophosphate, such as monophenyl dichlorophosphate. This process can, in particular, be used to make certain di(hydroxy-o-alkylphenyl) phenyl phosphate compounds, preferably those that are p-hydroxy, such as di(p-hydroxy-o-t-butylphenyl) phenyl phosphate.Type: GrantFiled: April 15, 2002Date of Patent: November 12, 2002Assignee: Akzo Nobel NVInventors: Danielle A. Bright, Jeffrey E. Telschow
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Publication number: 20020151739Abstract: A process for the formation of a di(hydroxyalkylaryl) aryl phosphate is disclosed which comprises the reaction of an o-alkyl substituted aromatic diol, e.g., an o-alkyl substituted hydroquinone such as o-t-butylhydro-quinone, and monoaryl dihalophosphate, such as monophenyl dichlorophosphate. This process can, in particular, be used to make certain di(hydroxy-o-alkylphenyl) phenyl phosphate compounds, preferably those that are p-hydroxy, such as di(p-hydroxy-o-t-butylphenyl) phenyl phosphate.Type: ApplicationFiled: April 15, 2002Publication date: October 17, 2002Inventors: Danielle A. Bright, Jeffrey E. Telschow
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Patent number: 6242631Abstract: The invention relates to a composition of mixed alkylated triphenyl phosphate esters comprising no less than 65% to about 100%, by weight, monoalkylphenyl diphenyl phosphate, up to about 30%, by weight, dialkylphenyl phenyl phosphate, up to about 3%, by weight, trialkylphenyl phosphate, and up to about 5%, by weight, triphenyl phosphate. The alkyl moieties can be isopropyl, isobutyl tertiary-butyl, isoamyl, tertiary-amyl, isooctyl and/or isononyl. The fluids prepared according to the previously described method show unusually low air entrainment values of less than 180 seconds, and as low as 20 seconds, and have a content of triphenyl phosphate that typically varies from about 0 to about 5.0%.Type: GrantFiled: July 16, 1999Date of Patent: June 5, 2001Assignee: Akzo Nobel NVInventors: Richard Hombek, Theodore A. Marolewski, Mark Buczek
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Patent number: 6218344Abstract: Lubricants for satellite applications consist essentially of a base fluid having low volatility and a minor amount, i.e., about 0.1 to 10 weight percent, of a chlorinated tris(phenoxyphenyl)phosphate.Type: GrantFiled: January 21, 2000Date of Patent: April 17, 2001Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Lois J. Gschwender, Carl E. Snyder, Jr.
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Patent number: 6150443Abstract: Provided are a flame-retardant polycarbonate resin composition capable of being formed into moldings having good impact resistance, high strength and good thermal stability that are intrinsic to polycarbonate resins and having good antistatic properties and good flame retardancy, and also injection moldings of the composition. The composition comprises 100 parts by weight of a resin or resin mixture of (A) from 50 to 100% by weight of a polycarbonate resin and (B) from 0 to 50% by weight of a styrenic resin, from 1 to 50 parts by weight of (C) a flame retardant, and from 0.1 to 5 parts by weight of (D) an anionic antistatic agent, and has a sodium sulfate content of at most 0.05% by weight. Optionally, the composition may contain (F) a fluoro-olefinic resin, (G) a rubber-like elastomer, and (H) an inorganic filler.Type: GrantFiled: August 9, 1999Date of Patent: November 21, 2000Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Akio Nodera, Naoki Mitsuta
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Patent number: 6140399Abstract: The invention relates to a polymeric composition comprising at least one engineering polymer and at least one phosphate ester flame retardant additive which is characterized in that the phosphate ester is a mixed tri (tertiary butylphenyl) phosphate ester which comprises from 1 to 45% by weight of tri (tertiary butylphenyl) phosphate; from 10 to 55% by weight of di tertiary butylphenyl mono phenyl phosphate; from 10 to 60% by weight of mono tertiary butylphenyl diphenyl phosphate and less than 10% by weight of triphenyl phosphate.Type: GrantFiled: February 3, 1999Date of Patent: October 31, 2000Assignee: Great Lakes Chemical (Europe) GmbHInventor: Sheila Munro
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Patent number: 5663461Abstract: A process for producing geranylgeraniol is provided, which comprising the steps of subjecting a mixture of at least one ester derivative wherein one or more carbon-carbon double bonds in the molecule are in cis form represented by the general formula (1): ##STR1## wherein R represents an aromatic group which can be substituted with at least one substituent, or a higher aliphatic group having from 7 to 25 carbon atoms, and wavy lines, respectively, represent a state where each carbon-carbon double bond can be present in cis or trans form, and an ester derivative of the general formula (2): ##STR2## wherein R is as defined above, to crystallization to obtain the ester derivative of the formula (2) selectively, and hydrolyzing the thus obtained ester derivative.Type: GrantFiled: November 6, 1995Date of Patent: September 2, 1997Assignee: Kuraray Co., Ltd.Inventors: Toshiki Mori, Junko Sato, Takashi Fukumoto, Kozo Nakao, Yoshin Tamai
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Patent number: 5550277Abstract: Perfluoroalkyl and perfluoroalkylether substituted aromatic phosphates, phosphonates and related compositions prepared by reaction of pefluoroalkyl or pefluoroakylether substituted phenols with mono- and dihalophosphite and primary and secondary phosphonyl halides are disclosed. These materials are useful as antioxidant, anticorrosion, antirust, and lubricity enhancing agents for perfluoropolyalkylether fluids.Type: GrantFiled: January 19, 1995Date of Patent: August 27, 1996Inventors: Kazimiera J. L. Paciorek, Wen-Huey Lin, Steven R. Masuda, James H. Nakahara
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Patent number: 5278212Abstract: A flow modifier for a thermoplastic resin, which is a hydroxyphenyl-containing organophosphorus compound represented by formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each represents a hydroxyl group, ##STR2## a hydrogen atom, or an alkyl group having 1 to 6 carbon atoms; a, b, c, and d each represents an integer of from 1 to 3; n represents 0 or an integer of from 1 to 3; when n is 0 or 1, the compound contains one hydroxyl group or ##STR3## group per molecule; and when n is 2 or 3, the compound contains one or two, in total, of hydroxyl group and ##STR4## group per molecule and thermoplastic resin composition containing the flow modifier is disclosed.Type: GrantFiled: October 13, 1992Date of Patent: January 11, 1994Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Hajime Nishihara, Katsuaki Maeda, Hiroaki Ishikawa, Hiroshi Mikami
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Patent number: 5210261Abstract: Amine salts of phosphorothioic acids, useful for example in lubricant compositions, are made by forming a mixture of sulphur and an amine, and then adding a phosphite ester. The reaction is controlled by the rate of addition of the ester.Type: GrantFiled: April 8, 1992Date of Patent: May 11, 1993Assignee: Ethyl Petroleum Additives, Ltd.Inventors: Barrie D. James, Roger Scattergood
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Patent number: 5206404Abstract: The invention is a novel composition of alkylated phenyl phosphate esters comprising by weight 1% to 20% trialkylphenyl phosphate, 10% to 50% dialkylphenyl monophenyl phosphate, 15% to 60% monoalkylphenyl diphenyl phosphate and less than 2% triphenyl phosphate and a process for preparing the composition comprising passing the composition at least once through a thin film evaporator at a temperature of about 200.degree. C. to about 250.degree. C. at a pressure sufficiently less than 5 kPa to evaporate about 5% to about 30% of the composition.Type: GrantFiled: April 27, 1992Date of Patent: April 27, 1993Assignee: FMC CorporationInventors: Louis T. Gunkel, Douglas G. Placek, Michael P. Marino, Jr., John Crosby, Sundeep G. Shankwalkar
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Patent number: 5196130Abstract: A tris[4-(chlorophenoxy)phenyl] phosphate of the formula: ##STR1## wherein n has a value of 1 to 5. This compound is effective as a lubricity additive for high temperatures lubricants.Type: GrantFiled: December 9, 1991Date of Patent: March 23, 1993Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Lois J. Gschwender, Carl E. Synder, Jr.
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Patent number: 5138085Abstract: The invention is a process for purifying a solid, storage-stable tris(bromophenyl)phosphate ester dissolving a crude tris(bromophenyl)phosphate in an ester at an elevated temperature, and cooling the solution sufficiently to recover a solid phase.Type: GrantFiled: May 28, 1991Date of Patent: August 11, 1992Assignee: FMC CorporationInventor: Louis T. Gunkel
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Patent number: 5130452Abstract: Compounds of general formula I ##STR1## wherein X.sub.1 is chloro or bromo,X.sub.2 is chloro, bromo or hydrogen, andY is O or S, andR.sub.1 and R.sub.2 are each independently of the other C.sub.1 -C.sub.4 alkyl, andR.sub.3 and R.sub.4 is a group of formula II ##STR2## which carries identical or different substituents and wherein R.sub.1, R.sub.2, X.sub.1 and X.sub.2 are as defined above, or R.sub.3 and R.sub.4, when taken together, form a group of formula III ##STR3## wherein R.sub.1 and R.sub.2 are as defined above, are very suitable flame retardants for polymers.Type: GrantFiled: May 6, 1991Date of Patent: July 14, 1992Assignee: Ciba-Geigy CorporationInventors: Peter Flury, Wolfgang Scharf
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Patent number: 5128496Abstract: The invention is a process for preparing a solid, storage-stable tris(bromophenyl)phosphate ester by the phosphorylation of a bromophenol and recovering the product by cooling a solution of the reaction mixture from a hydrocarbon solvent containing 2 to 20 parts of a C5 to C10 alkane per part of a C6 to C10 arene.Type: GrantFiled: May 28, 1991Date of Patent: July 7, 1992Assignee: FMC CorporationInventor: Louis T. Gunkel
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Patent number: 4814448Abstract: Certain phenyl and N-heterocyclic phosphorothioates and phosphates are prepared by the reaction of an appropriate alkali metal or alkaline earth metal -O-phenyl or N-heterocyclic compound with an appropriate phosphorochloridate or phosphorochloridothioate under alkaline conditions in a liquid reaction medium and in the presence of a tertiary amine catalyst and a nonionic surfactant having a HLB Value of from about 2.5 to about 20 or more.Type: GrantFiled: March 6, 1987Date of Patent: March 21, 1989Assignee: The Dow Chemical CompanyInventors: Sterling C. Gatling, Karl L. Krumel
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Patent number: 4814451Abstract: Certain phenyl and N-heterocyclic phosphorothioates and phosphonothioates and phosphates are prepared by the reaction of an appropriate alkali metal or alkaline earth metal --0-phenyl or N-heterocyclic compound with an appropriate phosphorochloridate, phosphorochloridothioate, phosphonochloridate or phosphonochloridothioate under alkaline conditions in the presence of a tertiary amine catalyst and a nonionic surfactant having an HLB Value of from about 1 to about 20, preferably about 5 to 15, in a two-phase system, one phase being primarily the phosphorate or phosphonate reactant and a complex thereof with the tertiary amine catalyst and the other phase being an aqueous reaction medium comprising water, a buffer system, and the alkali metal or alkaline earth metal-O-phenyl or --O-N-heterocyclic compound, in the substantial or complete absence of an organic solvent the aqueous reaction medium being maintained at pH about 10 to 12 by the buffer system.Type: GrantFiled: March 20, 1987Date of Patent: March 21, 1989Assignee: The Dow Chemical CompanyInventor: Sterling C. Gatling
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Patent number: 4724265Abstract: Liquid mixed triaryl thiophosphate mixtures can be prepared by forming a mixture of phenol and substituted phenols, forming a phosphite from that mixture and sulfurizing the phosphite, washing the thiophosphate with aqueous base, and drying the so washed thiophosphate under mild conditions. The products are liquid while containing at least 25 percent symmetrical triaryl thiophosphate. Colorless and odorless products are prepared.Type: GrantFiled: May 15, 1986Date of Patent: February 9, 1988Assignee: Stauffer Chemical CompanyInventors: Fred Jaffe, Alan M. Aaronson