The -c(=x)x- Is -c(=s)o- Patents (Class 558/234)
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Patent number: 5132441Abstract: Disclosed is an amino acid derivative represented by the general Formula (I): ##STR1## wherein R is a group whose conjugate acid has a pKa ranging from 10 to 16, R' is a straight chain alkyl group having 12 to 20 carbon atoms, n is an integer of 0 to 4, and X is --O--, --NH-- or --S--. These amino acid derivatives each having various eliminative groups can be synthesized by simple steps using optically active amino acids.Type: GrantFiled: January 18, 1990Date of Patent: July 21, 1992Assignee: Fuji Photo Film Co., Ltd.Inventor: Mitsunori Ono
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Patent number: 5099030Abstract: The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.Type: GrantFiled: June 27, 1991Date of Patent: March 24, 1992Assignee: The Procter & Gamble CompanyInventors: Joseph H. Gardner, Gerald B. Kasting, Thomas L. Cupps, Richard S. Echler, Thomas W. Gibson, Joel I. Shulman
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Patent number: 5066674Abstract: Certain carbamate esters are used as inhibitors as cholesterol esterase and function as hypolipidemic and hypocaloric agents. The invention also relates to a method of decreasing the absorption of dietary cholesterol and fats through the wall of the intestinal tract.Type: GrantFiled: June 4, 1990Date of Patent: November 19, 1991Assignee: University of Iowa Research FoundationInventor: Daniel M. Quinn
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Patent number: 5057610Abstract: Substituted amino carbamate derivatives corresponding to the formula ##STR1## are effective in stabilizing organic materials against oxidative, thermal and actinic degradation, said derivatives being particularly effective as color improvers and process stabilizers in organic materials containing phenolic antioxidants and/or metal salts of fatty acids and/or hindered amine light stabilizers and/or organic phosphorus compounds; and certain of said derivatives as new compounds.Type: GrantFiled: April 25, 1988Date of Patent: October 15, 1991Assignee: Ciba-Geigy CorporationInventors: Stephen D. Pastor, Edward T. Hessell, Ramanathan Ravichandran
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Patent number: 5045565Abstract: The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.Type: GrantFiled: September 8, 1989Date of Patent: September 3, 1991Assignee: The Procter & Gamble CompanyInventors: Joseph H. Gardner, Gerald B. Kasting, Thomas L. Cupps, Richard S. Echler, Thomas W. Gibson, Joel I. Shulman
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Patent number: 5041599Abstract: Catalytic processes for the synthesis of thionocarbamates by contacting xanthates, and amines, especially primary amines in the presence of at least one suitable catalyst. Suitable catalysts for these processes include finely divided metallic catalysts such as suspended nickel and precious metal(s); for example, Raney Nickel or platinum/palladium on carbon support. Reaction is carried out at a most preferred temperature of from about 70.degree. C. to about 80.degree. C. and for about 8 hours to about 12 hours for example.Type: GrantFiled: July 30, 1990Date of Patent: August 20, 1991Assignee: Phillips Petroleum CompanyInventors: Marshall D. Bishop, Lowell A. Gray
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Patent number: 5037991Abstract: Substituted phenoxy, phenylthio and anilino compounds, intermediates therefor, synthesis thereof, and their use for the control of pests.Type: GrantFiled: October 3, 1990Date of Patent: August 6, 1991Assignee: Sandoz Ltd.Inventor: Clive A. Henrick
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Patent number: 5015644Abstract: Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol, and for lowering blood plasma cholesterol.Type: GrantFiled: June 1, 1989Date of Patent: May 14, 1991Assignee: Warner-Lambert CompanyInventors: Bruce D. Roth, Bharat K. Trivedi
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Patent number: 4968829Abstract: Substituted phenoxy, phenylthio and anilino compounds, intermediates therefor, synthesis thereof, and their use for the control of pests.Type: GrantFiled: June 19, 1989Date of Patent: November 6, 1990Assignee: Sandoz Ltd.Inventor: Clive A. Henrick
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Patent number: 4963583Abstract: Novel 3-acyloxy-4-keto-.beta.-ionone derivatives of the formula I ##STR1## wherein Z is either the radical ##STR2## in which R.sub.1 represents C.sub.2 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy-C.sub.1 -C.sub.5 alkyl having a maximum number of 6 carbon atoms, cyclopropyl or cyclopropyl which is substituted by methyl or by halogen or represents the radical ##STR3## wherein R.sub.2 represents C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy-C.sub.1 -C.sub.5 alkyl having a maximum number of 6 carbon atoms, cyclopropyl or cyclopropyl which is substituted by methyl or by halogen and X represents either oxygen or sulphur, and ##STR4## display very effective microbicidal activity. They can especially be used in microbicidal compositions to control plant-pathogenic microorganisms, preferably fungi of the order Oomycetes.Type: GrantFiled: September 28, 1988Date of Patent: October 16, 1990Assignee: Ciba-Geigy CorporationInventor: Walter Kunz
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Patent number: 4945111Abstract: Fungicidal N,N'-diacylaminals of the formula ##STR1## in which R.sup.1 is optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl,R.sup.2 and R.sup.3 are hydrogen or various organic radicals, andX is oxygen or sulphur.Type: GrantFiled: August 11, 1988Date of Patent: July 31, 1990Assignee: Bayer AktiengesellschaftInventors: Winfried Lunkenheimer, Dieter Berg, Wilhelm Brandes
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Patent number: 4889953Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is a higher alkyl group which may be substituted; R.sup.2 is a hydrogen, a lower alkyl group which may be substituted, a lower alkanoyl group which may be substituted or a lower alkylthiocarbamoyl group; R.sup.3 is a primary to tertiary amino group or a quaternary ammonium group; and n is 2 or 3, and salts thereof, have antitumor activity and platelet activating factor inhibitory activity.Type: GrantFiled: July 22, 1987Date of Patent: December 26, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Keizo Inoue, Hiroaki Nomura, Tetsuya Okutani
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Patent number: 4888043Abstract: The invention concerns compounds of the formula I ##STR1## wherein: Z is selected from hydrogen, alkyl, alkanoyl, sulfamoyl, carboxy and trifluoroacetamido;Y is selected from various carboxy or thiocarboxy groups, haloalkanoyl, alkylsulfonyl and haloalkylsulfonyl;R.sup.1 is selected from hydrogen, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl and alkynyl;R.sup.3 is selected from alkyl; andR.sup.4 is selected from hydrogen, alkyl, and alkoxycarbonyl.The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments and the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.Type: GrantFiled: June 20, 1986Date of Patent: December 19, 1989Assignee: ICI Australia LimitedInventors: Keith G. Watson, Craig G. Lovel
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Patent number: 4791216Abstract: There are provided paraethylamine phenol compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds.Type: GrantFiled: December 5, 1986Date of Patent: December 13, 1988Assignee: Fisons plcInventors: Francis Ince, Alan C. Tinker
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Patent number: 4777282Abstract: Organic compounds having functional groups such as aromatic ester, thioester, or carbonate groups are prepared by reacting an organo- germanium, tin, or lead reactant with a suitable second reactant. For example, the ester ##STR1## is prepared by reacting the bis-tri-n-butyl tin derivative of hydroquinone with p-phenoxybenzoyl chloride.Type: GrantFiled: June 3, 1986Date of Patent: October 11, 1988Assignee: Raychem LimitedInventor: Ian D. H. Towle
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Patent number: 4761175Abstract: m-Anilido-urethanes of the formula ##STR1## where A and B independently of one another are oxygen or sulfur,R.sup.1 is alkyl, which is unsubstituted or substituted by halogen, alkoxy, alkoxycarbonyl or cyano, or is alkenyl which is unsubstituted or substituted by halogen, or is alkynyl which is unsubstituted or substituted by halogen or alkoxy, or is cycloalkyl which is unsubstituted or substituted by alkyl, or is aryl,R.sup.2 and R.sup.3 are each independently of one another hydrogen, alkyl, alkoxyalkyl or haloalkyl,R.sup.4 is alkylene of 1 to 6 carbon atoms which is unsubstituted or substituted by alkyl, alkoxyalkyl or haloalkyl,X is hydrogen, alkyl, haloalkyl, alkoxy, halogen, nitro or amino,Y is hydrogen, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl, halogen, alkoxy, haloalkoxy, alkylthio, nitro, aryl, thiocyanato, cyano, ##STR2## where R.sup.5 and R.sup.6 are each, independently of one another, hydrogen or have the meanings given for R.sup.Type: GrantFiled: July 5, 1983Date of Patent: August 2, 1988Assignee: BASF AktiengesellschaftInventors: Ulrich Schirmer, Rainer Becker, Bruno Wuerzer
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Patent number: 4752615Abstract: A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole, thiophanate and/or cyclic imide fungicides.Type: GrantFiled: November 13, 1986Date of Patent: June 21, 1988Assignee: Sumitomo Chemical Company, LimitedInventors: Junya Takahashi, Toshiro Kato, Hiroshi Noguchi, Yukio Oguri, Shigeo Yamamoto, Katsuzo Kamoshita
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Patent number: 4736056Abstract: This invention relates to a process for preparing a malonic acid derivative compound of formula (i) depicted herein in high yield and high purity by reacting a malonic acid derivative compound of formula (ii) depicted herein with an alkylating agent of formula (iii) depicted herein in the presence of a solvent and a base.Type: GrantFiled: December 15, 1986Date of Patent: April 5, 1988Inventors: Oliver W. Smith, Russell J. Outcalt
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Patent number: 4729843Abstract: The present invention provides a new collector for use in the froth flotation of metal values from their ores. The collector comprises a synergistic mixture of alkyl xanthogen alkyl formates and dialkyl thionocarbamates, and yields metal recoveries superior to that achieved with either collector alone. According to the present invention the novel collector for use in froth flotation comprises a mixture of alkyl xanthogen alkyl formates having the general formula: ##STR1## wherein R is a branched or straight chain alkyl substituent having 1 to 6 carbon atoms, and R' is selected from the class consisting of ethyl and methyl; anddialkyl thionocarbamates having the general formula: ##STR2## wherein Y is a branched or straight chain alkyl substituent having 1 to 6 carbon atoms, and Y' is selected from the class consisting of ethyl and methyl.Type: GrantFiled: March 4, 1986Date of Patent: March 8, 1988Assignee: Essex Industrial Chemicals, Inc.Inventor: Kim N. Unger
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Patent number: 4721782Type: GrantFiled: October 10, 1985Date of Patent: January 26, 1988Assignee: Bayer AktiengesellschaftInventor: Fritz Maurer
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Patent number: 4697033Abstract: Certain novel derivatives of carbamates and their use for the control of pests.Type: GrantFiled: December 24, 1985Date of Patent: September 29, 1987Assignee: Sandoz Ltd.Inventor: Clive A. Henrick
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Patent number: 4672138Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.Type: GrantFiled: February 3, 1986Date of Patent: June 9, 1987Assignee: Hoechst Roussel Pharmaceuticals Inc.Inventors: Helen H. Ong, James A. Profitt
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Patent number: 4657688Abstract: New and improved collector compositions for use in froth flotation processes for the beneficiation of mineral values from base metal sulfide ores are disclosed. The collector compositions comprise at least one hydrocarboxycarbonyl thionocarbamate compound selected from compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, selected from saturated and unsaturated hydrocarbyl radicals, alkyl polyether radicals and aromatic radicals, or such radicals optionally substituted by polar groups selected from halogen, nitrile and nitro groups. The use of the hydrocarboxycarbonyl thionocarbamate collectors provides excellent metallurgical recoveries of sulfide mineral values in froth flotation processes conducted over a broad range of pH conditions including acid, neutral and mildly alkaline pH.Type: GrantFiled: December 9, 1985Date of Patent: April 14, 1987Assignee: American Cyanamid CompanyInventors: Yun-Lung Fu, Samuel S. Wang
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Patent number: 4643763Abstract: The invention concerns novel compounds of the formula I ##STR1## wherein: m is an integer selected from 1 to 4;n is zero or an integer selected from 1 to 4;x are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, alkylthio, sulfamoyl, substituted sulfamoyl, amino, substituted amino, the group --(CH.sub.2).sub.p C(.dbd.A)Z in which p is zero or one A is oxygen or sulfur, and Z is hydrogen, hydroxy, alkoxy, alkylthio, alkyl, substituted alkyl, amino or substituted amino; the group --NHC(.dbd.B(NR.sup.7 R.sup.8 in which B is oxygen or sulfur and R.sup.7 and R.sup.8 are hydrogen or alkyl;R.sup.1 is selected from hydrogen, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl; andR.sup.4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl.Type: GrantFiled: September 10, 1985Date of Patent: February 17, 1987Assignee: ICI Australia LimitedInventors: Graeme J. Farquharson, Keith G. Watson, Graham J. Bird
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Patent number: 4618461Abstract: The invention relates to novel O,O'-, O,S'- or S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamothioates) and S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamodithioate). The novel compounds of this invention are useful as collectors in the froth flotation of sulfide mineral ores.Type: GrantFiled: July 25, 1983Date of Patent: October 21, 1986Assignee: The Dow Chemical CompanyInventors: Roger W. Bergman, Harry A. Smith
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Patent number: 4605668Abstract: A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, and particularly the strains resistant to benzimidazole, thiophanate and/or cyclic imide fungicides.Type: GrantFiled: April 12, 1984Date of Patent: August 12, 1986Assignee: Sumitomo Chemical Company, LimitedInventors: Junya Takahashi, Toshiro Kato, Hiroshi Noguchi, Yukio Oguri, Shigeo Yamamoto, Katsuzo Kamoshita
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Patent number: 4605519Abstract: The invention relates to novel O- or S-(2-mercaptoalkyl)mono- or dihydrocarbyl carbamothioates and S-(2-mercaptoalkyl)mono- or dihydrocarbyl carbamodithioate. The novel compounds of this invention are useful as collectors in the froth flotation of sulfide mineral ores.Type: GrantFiled: December 9, 1983Date of Patent: August 12, 1986Assignee: The Dow Chemical CompanyInventor: Roger W. Bergman
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Patent number: 4599106Abstract: A substituted alkanethiocarboxylic acid derivative of the formula ##STR1## in which A represents a CH grouping,X.sup.1 represents hydrogen, trifluoromethyl or chlorine,X.sup.2 and X.sup.3 independently of one another represent hydrogen, trifluoromethyl or chlorine,R.sup.1 represents hydrogen or methyl andR.sup.2 represents hydrogen or optionally substituted radicals from the series comprising alkyl, alkenyl, alkinyl, aryl, aralkyl, aralkoxyalkyl and cycloalkyland its use in a herbicidal composition for combating weeds.Type: GrantFiled: May 22, 1985Date of Patent: July 8, 1986Assignee: Bayer AktiengesellschaftInventors: Heinz Forster, Ludwig Eue, Robert R. Schmidt
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Patent number: 4584318Abstract: A method is described for the control of nematodes in agricultural crops which comprises applying to the situs of infestation of a nematicidal composition containing as active ingredient a compound of the formula ##STR1## wherein Q is hydroxy, carbamoyloxy, or acyloxy, R is alkyl, alkenyl, alkynyl, X is halogen or methyl, n is 1 or 2. Preparation of active ingredient compounds is described, and nematicidal utility of compositions is exemplified.Type: GrantFiled: June 20, 1983Date of Patent: April 22, 1986Assignee: FMC CorporationInventors: Clinton J. Peake, Carmine P. DiSanzo, John F. Engel
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Patent number: RE32827Abstract: New and improved collector compositions for use in froth flotation processes for the beneficiation of mineral values from base metal sulfide ores are disclosed. The collector compositions comprise at least one hydrocarboxycarbonyl thionocarbamate compound selected from compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, selected from saturated and unsaturated hydrocarbyl radicals, alkyl polyether radicals and aromatic radicals, or such radicals optionally substituted by polar groups selected from halogen, nitrile and nitro groups. The use of the hydrocarboxycarbonyl thionocarbamate collectors provides excellent metallurgical recoveries of sulfide mineral values in froth flotation processes conducted over a broad range of pH conditions including acid, neutral and mildly alkaline pH.Type: GrantFiled: July 30, 1987Date of Patent: January 10, 1989Assignee: American CyanamidInventors: Yun-Lung Fu, Samuel S. Wang