Nitrogen Bonded Directly To The Carbon Of The -c(=x)x- Group (e.g., Thiocarbamates, Etc.) Patents (Class 558/232)
  • Publication number: 20150141678
    Abstract: What is described is a compound of formula (1) wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbon atoms; L1 and L2 are the same or different, each a linear alkyl having 5 to 18 carbon atoms, or form a heterocycle with N; X1 is a bond, or is —CO—O— whereby L2-CO—O—R2 is formed; X2 is S or O; L3 is a bond or a lower alkyl, or form a heterocycle with N; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 21, 2015
    Inventors: Joseph E. Payne, Padmanabh Chivukula
  • Patent number: 8106141
    Abstract: Reaction products prepared from reactants including: (a) at least one compound of structural Formula (I): wherein R1 is selected from aryl and heteroaryl; X is selected from a direct bond, —O—, —S—, —NH—, alkylene, cycloalkylene, heterocyclylene, arylene, alkarylene, and heteroarylene; Y is a substituted alkylene group having at least two contiguous carbon atoms and which can be interrupted by one or more —O—, —S—, or —NH— moieties as defined herein, wherein the alkylene group of Y has substituents independently selected from —OH, —NH2, —SH, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or two hydrogen atoms on the same carbon atom of Y are replaced by carbonyl, and wherein at least two substituents of Y are each independently selected from —OH, —NH2, and —SH, as defined herein; and (b) at least one isocyanate functional material.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: January 31, 2012
    Assignee: Henkel Corporation
    Inventors: Anthony F. Jacobine, Andrew Messana, David M. Glaser, Steven Thomas Nakos
  • Patent number: 7589226
    Abstract: A novel hydroxyalkyldithiocarbamate borate ester compound is presented according to the formula: where R=alkyl C1 to C25; R?=H or CO2R; R?=(CH2)mOH where m=1 to 8, or alkyl C1 to C25; n=1 to 8. The borate ester compound is prepared by reacting boric acid with a novel hydroxyalkyldithiocarbamate ester compound according to the formula, and optionally with an alcohol: where R, R?, R? and n are as above. The hydroxyalkyldithiocarbamate ester is prepared by reacting a hydroxyalkylamine with CS2, and an acrylate or maleate compound. A lubricating composition is based on a major amount of lubricating oil and a minor amount of the hydroxyalkyldithiocarbamate borate ester.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: September 15, 2009
    Assignee: R.T. Vanderbilt Company, Inc.
    Inventors: Kevin J. Chase, Ronald Tepper
  • Patent number: 7563837
    Abstract: Thiocarbamides comprising at least one carbodiimide group and at least one thiocarbamic ester group of the formula
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: July 21, 2009
    Assignee: BASF Aktiengesellschaft
    Inventors: Andre Burghardt, Karl Haeberle, Ulrike Licht, Karl-Heinz Schumacher
  • Patent number: 7521401
    Abstract: Fuels, especially hydrocarbon fuels, and lubricants, especially lubricating oils, contain dithiocarbamyl ?-hydroxy fatty acid esters, a class of anti-corrosion, anti-wear, anti-fatigue, and extreme pressure additives that are derived from epoxidized fatty acid esters. The additives exhibit synergistic anti-wear activity in combination with phosphorus containing additives.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: April 21, 2009
    Assignee: ChemTura Corporation
    Inventor: Robert G. Rowland
  • Patent number: 7282599
    Abstract: The invention discloses a use of dithiocarbamate compounds having the structural formula R1R2NCS2H, in which R1 and R2, independently of each other, represent a straight or branched C1-C4 alkyl, or, with the nitrogen atom, form an aliphatic ring with 4 to 6 C atoms, in which R1, R2, or the aliphatic ring is optionally substituted with one or more substituents selected from OH, NO2, NH2, COOH, SH, F, Cl, Br, I, methyl or ethyl, and oxidized forms of these compounds, in particular dimers thereof, as well as pharmaceutically acceptable salts thereof, to prepare an agent for treating or preventing an infection by RNA viruses which attack the respiratory tract and cause disease there.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: October 16, 2007
    Assignee: Avir Green Hills Biotechnology Research Devlopment Trade AG
    Inventors: Elisabeth Gaudernak, Andreas Grassauer, Ernst Küchler, Thomas Muster, Joachim Seipelt
  • Patent number: 7112558
    Abstract: The invention relates to a lubricating composition comprising a base oil of lubricating viscosity, a hydroxy-substituted dithiocarbamate, an organo-molybdenum compound, and optionally a phosphorous source.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: September 26, 2006
    Assignee: Afton Chemical Intangibles LLC
    Inventor: Vincent J. Gatto
  • Publication number: 20040171680
    Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
    Type: Application
    Filed: October 17, 2003
    Publication date: September 2, 2004
    Inventors: Xiiaoli Chen, Keith T. Demarest, Jung Lee, Jay M. Matthews, Philip Rybczynski
  • Publication number: 20040147587
    Abstract: The invention relates to compounds for the modulation of the glycolysis enzyme complex and of the transaminase complex, pharmaceutical compositions containing such compounds as well as uses of such compounds for preparing pharmaceutical compositions for treating various diseases.
    Type: Application
    Filed: July 11, 2003
    Publication date: July 29, 2004
    Applicant: ScheBo Biotech AG
    Inventors: Erich Eigenbrodt, Hans Scheefers, Sybille Mazurek
  • Publication number: 20040077691
    Abstract: In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and 5-lipoxygenase (5-LO); as anticancer agents (through promoting apoptosis and/or inhibiting the matrix metalloproteinases (MMPs)); as anti-diabetics; and the like. Invention compounds comprise a non-steroidal anti-inflammatory agent (NSAID), covalently linked to a hydroxamate. Invention compounds are useful alone or in combination with one or more additional pharmacologically active agents, and can be used for a variety of applications, such as, for example, treating inflammation and inflammation-related conditions; reducing the side effects associated with administration of anti-inflammatory agents; promoting apoptosis; inhibiting matrix metalloproteinases; as anti-diabetic agents; and the like.
    Type: Application
    Filed: October 21, 2002
    Publication date: April 22, 2004
    Applicant: Medinox, Inc.
    Inventors: Tingmin Wang, Ching-San Lai
  • Publication number: 20040034069
    Abstract: A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.
    Type: Application
    Filed: August 8, 2003
    Publication date: February 19, 2004
    Inventors: Syed M. Ali, Kurt R. Brunden, Jack B. Jiang
  • Patent number: 6686494
    Abstract: A method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting a precursor thiol reagent with trichloroacetyl chloride to produce an S-alkyl and S-aryl trichloroacetyl thioester intermediate, which is reacted with an amine to yield the corresponding thiocarbamate product. Also disclosed is the method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting an amine with trichloroacetyl chloride to produce a trichloroacetamide intermediate, which is then reacted with the precursor thiol to yield the corresponding thiocarbamate product.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: February 3, 2004
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: James W. Wynne, Arthur W. Snow
  • Patent number: 6683201
    Abstract: The present invention relates to compounds of formula (I) wherein U, Y, V, W, L, X, A1, A2, A3, A4, A5 and A6 are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and/or treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: January 27, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Alexander Chucholowski, Henrietta Dehmlow, Olivier Morand, Sabine Wallbaum, Thomas Weller
  • Publication number: 20030119853
    Abstract: Compounds of formula (1): 1
    Type: Application
    Filed: December 20, 2002
    Publication date: June 26, 2003
    Inventors: Sarah Catherine Archibald, John Clifford Head, Graham John Warrellow, John Robert Porter
  • Publication number: 20030120101
    Abstract: Dithiocarbonate derivatives are disclosed, along with a process for preparing the same. The dithiocarbonate compounds can be utilized as initators, chain transfer agents and/or terminators in controlled free radical polymerizations. The dithiocarbonates can be used to produce polymers having narrow molecular weight distribution. Advantageously, the compounds of the present invention can also introduce functional groups into the resulting polymers. The dithiocarbonate compounds have low odor and are substantially colorless.
    Type: Application
    Filed: October 23, 2002
    Publication date: June 26, 2003
    Inventor: John Ta-Yuan Lai
  • Publication number: 20030087829
    Abstract: Disclosed are novel compounds and novel pharmaceutical compositions for use in medical therapy, as well as intermediates and processes for preparing such compounds. Therapeutic methods for preventing or treating glutamate-related disorders in a mammal and methods to inhibit or prevent glutamate binding in mammalian tissue are also disclosed.
    Type: Application
    Filed: October 28, 2002
    Publication date: May 8, 2003
    Inventors: Morris Faiman, John V. Schloss, Jang-Yen Wu
  • Publication number: 20030088056
    Abstract: Polyamides comprising at least one hydrophilic C1-C10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided.
    Type: Application
    Filed: July 16, 2002
    Publication date: May 8, 2003
    Inventor: Annelise E. Barron
  • Publication number: 20030013125
    Abstract: The present invention provides compounds and libraries of compounds having formula (I): 1
    Type: Application
    Filed: May 10, 2002
    Publication date: January 16, 2003
    Inventors: Andrew C. Braisted, Daniel A. Erlanson, Jeffrey W. Jacobs
  • Publication number: 20020107406
    Abstract: A novel calcium receptor active compound having the formula is provided:
    Type: Application
    Filed: January 17, 2002
    Publication date: August 8, 2002
    Applicant: NPS Pharmaceuticals, Inc.
    Inventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
  • Publication number: 20020103190
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 1, 2002
    Inventors: David Lauffer, Michael Mullican
  • Publication number: 20020019536
    Abstract: The present invention relates to urethanes and the thio and dithio analogues thereof of general formula 1
    Type: Application
    Filed: March 24, 1999
    Publication date: February 14, 2002
  • Patent number: 6140531
    Abstract: Describes a method of producing N-1-alkenyl carbonylamino compounds represented by the following general formula I, ##STR1## wherein R.sub.1 is the residue of an active hydrogen functional material, n is a number from 1 to a number equal to the number of active hydrogen groups of said active hydrogen functional material, X is selected from O, S and N(R.sub.5), R.sub.5 being hydrogen, hydrocarbyl, or R.sub.5 and R.sub.1 may together form a cyclic ring, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from hydrogen, C.sub.1 -C.sub.4 alkyl and C.sub.2 -C.sub.4 alkenyl.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: October 31, 2000
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Cheruthur Govindan, John M. Pascone
  • Patent number: 5969174
    Abstract: The present invention provides a compound having the structure ##STR1## wherein S* is S.dbd.O or O.dbd.S.dbd.O; and wherein R.sub.1 is selected from the group consisting of (C.sub.1 -C.sub.9) alkyl, (C.sub.3 -C.sub.8) cycloalkyl, (C.sub.5 -C.sub.7) cycloalkenyl, and (C.sub.6 -C.sub.20) aryl substituted with halogen or (C.sub.1 -C.sub.18) alkyl; and wherein R.sub.2 is selected from the group consisting of alkyl, (C.sub.1 -C.sub.9) alkyl, (C.sub.3 -C.sub.8) cycloalkyl, (C.sub.5 -C.sub.7) cycloalkenyl, and (C.sub.6 -C.sub.20) aryl substituted with halogen or (C.sub.1 -C.sub.18) alkyl. Also provided are various methods of using the compositions of the present invention.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: October 19, 1999
    Assignee: University of Maryland at Baltimore County
    Inventors: Donald Creighton, Malcolm J. Kavarana, Diana S. Hamilton
  • Patent number: 5955501
    Abstract: Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 21, 1999
    Assignee: Procyon Pharmaceuticals, Inc.
    Inventors: Paul E. Driedger, James Quick
  • Patent number: 5824661
    Abstract: Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S(b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing one or more heteroatoms selected from O, S, or N;(c) Q is covalent bond; O; or S;(d) R is COOH, SO.sub.3 H, PO.sub.3 H.sub.2, or P(O)(OH)R.sup.4, wherein R.sup.4 is C.sub.1 -C.sub.8 alkyl;(e) R.sup.1, R.sup.2 and R.sup.5 are as defined in the claims.are useful in the treatment of calcium and phosphate elated disorders, such as arthritis and the like.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: October 20, 1998
    Assignee: The Procter & Gamble Company
    Inventors: Marion David Francis, Susan Mary Kaas, Frank Hallock Ebetino
  • Patent number: 5811579
    Abstract: The present invention relates to a method of synthesizing a 2-substituted nitrogen containing compound having a formula (I): ##STR1## by reacting a hydroxylamine of formula (II); ##STR2## or a nitrone of formula (III): ##STR3## with a compound of formula (IV); ##STR4## thereby to form an intermediate compound, and thereafter causing or allowing said intermediate compound to undergo a pericyclic sigmatropic rearrangement reaction to form the compound (I); wherein X is a nucleofugal group, Y is selected from O,S,NH,NR.sub.5 and CR.sub.6 R.sub.7, R.sub.1 is a group which directs the reactivity of compound (II) on to the oxygen atom and R.sub.2 to R.sub.9 are each a substituted or unsubstituted aliphatic, aromatic, heteroaryl or cyclic group or hydrogen which is substantially inert or is protected during the reaction.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: September 22, 1998
    Assignee: Eastman Kodak Company
    Inventor: John DeMita Goddard
  • Patent number: 5750757
    Abstract: A process for the preparation of an S-alkyl ester of an N-alkyl carbamothioic acid having the formula: ##STR1## wherein R and R.sub.2 are each an alkyl group and R.sub.1 is hydrogen or alkyl, which includes refluxing the corresponding alkyl ester of N-alkyl thiocarbamio acid having the formula I ##STR2## wherein R and R.sub.2 are each alkyl and R.sub.1 is hydrogen or alkyl, in the presence of an acid catalyst selected from the group consisting of iodine and sulfuric acid.
    Type: Grant
    Filed: October 29, 1996
    Date of Patent: May 12, 1998
    Assignee: Council of Scientific and Industrial Research
    Inventors: Abdul Rakeeb Abdul Subhan Deshmukh, Rajan Hiralal Naik, Sagun Kashinath Tandel, Srinivasachari Rajappa
  • Patent number: 5565602
    Abstract: A process which can be used for producing thiolcarbamates is provided wherein the process comprises contacting a reaction mixture with a hydrocarbyl chloride such as, for example, benzyl chloride under a condition which is sufficient to produce a product mixture wherein the reaction mixture comprises carbonyl sulfide, an amine such as, for example, a secondary amine, a solvent; the solvent comprises a tertiary amine; and the reaction mixture, hydrocarbyl halide, and solvent are each present in an amount sufficient to effect the production of a thiolcarbamate. Optionally, the reaction mixture can also comprise a metal hydroxide. Further optionally, the product mixture can be contacted with a metal hydroxide if the reaction mixture does not comprise a metal hydroxide.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: October 15, 1996
    Assignee: Phillips Petroleum Company
    Inventors: Michael S. Matson, Dean E. Stinn, Michael D. Mitchell
  • Patent number: 5436352
    Abstract: The present invention provides metal chelating compounds, to chelates and chelate-targeting agent conjugates formed from the chelating compounds, and to methods for making and using these compositions. The chelating compounds incorporate two nitrogen atoms and three sulfur atoms ("N.sub.2 S.sub.3 "), two nitrogen atoms and four sulfur atoms ("N.sub.2 S.sub.4 "), or three nitrogen atoms and three sulfur atoms ("N.sub.3 S.sub.3 "). Metals, and metal oxides, capable of being chelated by the compounds include those that are radionuclides, such as .sup.99m Tc and .sup.186/188 Re.The targeting agent portion of the chelate-targeting agent conjugates provided includes antibodies, peptides, hormones, enzymes and biological response modifiers. Methods for making the conjugates are provided and encompass the addition of a metal, or metal oxide, to a chelating compound prior to attachment to a targeting agent as well as subsequent to the attachment.
    Type: Grant
    Filed: December 6, 1991
    Date of Patent: July 25, 1995
    Assignee: NeoRx Corporation
    Inventors: Ananthachari Srinivasan, Alan R. Fritzberg, David S. Jones
  • Patent number: 5248755
    Abstract: Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound having one or two non-cumulated olefinic double bonds, and a process for the preparation of N-mono- or N,N-disubstituted ureas by reaction of ammonium isocyanate with a primary or secondary amine in a diluent.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: September 28, 1993
    Assignee: Chemie Linz Gesellschaft m.b.H.
    Inventors: Martin Muller, Gerhard Stern, Erich Schulz, Markus Rossler
  • Patent number: 5247087
    Abstract: Dithiocarbamic salts made from the reaction products of certain polyamines and epoxides have been found to be useful to clarify water, particularly the oil-in-water emulsions which accompany crude oil production. The water clarification may be accomplished by demulsification or flocculation. The polyamine reaction products themselves are novel and may have the structure ##STR1## where R" is selected from the group consisting of the structure --R--NH.sub.2 and ##STR2## where R is selected from the group consisting of straight, branched or cyclic alkylene moieties; arylene moieties; substituted straight, branched or cyclic alkylene moieties; substituted arylene moieties or mixtures thereof; and where R' is--(CH.sub.2).sub.m --O--R--O--(CH.sub.2).sub.m --where n and m independently range from 1 to 5 and q is 0 or 1. The dithiocarbamic salts made from these polyamines also find use as corrosion inhibitors.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: September 21, 1993
    Assignee: Baker Hughes Incorporated
    Inventor: Gordon T. Rivers
  • Patent number: 5223635
    Abstract: Process for the removal of isocyanic acid from a gaseous mixture of isocyanic acid and ammonia by introducing a tertiary amine or ether at to C. The gaseous reaction mixture is passed into an inert diluent and cooled, to condense an adduct of isocyanic acid and tertiary amine or ether, and the ammonia being removed as a gas.
    Type: Grant
    Filed: September 25, 1991
    Date of Patent: June 29, 1993
    Assignee: Chemie Linz Gesellschaft m.b.H.
    Inventors: Martin Mullner, Gerhard Stern, Erich Schulz
  • Patent number: 5220059
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is selected from (1) hydrogen; (2) --NR.sub.2 R.sub.3, --OR.sub.2 or --SR.sub.2 where R.sub.2 and R.sub.3 are independently selected from hydrogen, alkyl, aryl and alkylaryl; and (3) optionally substituted C1-C8 alkyl, C2-C8 alkenyl, arylalkyl or cycloalkyl;Y is selected from sulfur and oxygen;n is an integer selected from 0 and 1;M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group; andZ is a residue of a non-steroidal antiinflammatory drug of general form Z--COOH;or a pharmaceutically acceptable salt, ester or prodrug thereof,as well as pharmaceutical compositions containing the above compounds and a method for their use as lipoxygenase inhibitors.
    Type: Grant
    Filed: April 19, 1990
    Date of Patent: June 15, 1993
    Assignee: Abbott Laboratories
    Inventors: Dee W. Brooks, Joseph F. Dellaria, Jr., James B. Summers, Jr.
  • Patent number: 5169643
    Abstract: A thiolcarbamate granule formulation comprising granules consisting essentially of Fuller's earth and a thiolcarbamate of the following formula I or II impregnated in the granules: ##STR1## wherein m is an integer of from 0 to 4, n is an integer of from 1 to 4, and p is an integer of from 1 to 5, provided that the sum of m+n+p is at most 7.
    Type: Grant
    Filed: April 27, 1990
    Date of Patent: December 8, 1992
    Assignee: Hodogaya Chemical Co., Ltd.
    Inventors: Hiroshi Kawada, Susumu Suzuki, Hiroki Tokunaga, Masaji Kikuta
  • Patent number: 5151540
    Abstract: A method is provided for preparing N-acylaminothiophenols, e.g., N-acetyl-para-aminothiophenol, or aminothiophenols, e.g., para-aminothiophenol, or N,S-diacylaminothiophenols, e.g., N,S-diacetyl-para-aminothiophenol, by reacting any of certain sulfur-containing ketones, viz., an S-(acylaryl) N,N-di(organo)thiocarbamate, e.g., S-(4'-acetophenyl)-N,N-dimethylthiocarbamate, an acylthiophenol acylate ester, e.g., 4-acetothiophenol acetate, or a free acylthiophenol, e.g., 4-acetothiophenol with hydroxylamine or a hydroxylamine salt, to form the oxime of the ketone, subjecting the oxime to a Beckmann rearrangement in the presence of a catalyst to form an S-(N-acyl-aminoaryl) N,N-di(organo)thiocarbamate, e.g., S-(N-acetyl-para-aminophenyl) N,N-dimethylthiocarbamate, an N,S-diacylaminothiophenol, e.g., N,S-diacetyl-paraaminothiophenol, or an N-acyl aminothiophenol, e.g., N-acetyl-para-aminothiophenol, respectively.
    Type: Grant
    Filed: November 26, 1986
    Date of Patent: September 29, 1992
    Assignee: Hoechst Celanese Corporation
    Inventors: Mohammad Aslam, Kenneth G. Davenport
  • Patent number: 5106740
    Abstract: A cofactor having an aromatic or benzylic amino group is converted into an isothiocyanate by reaction with a compound such as thiophosgene and the isothiocyanate of the cofactor is attached to a polymer which is preferably water-soluble. When the polymer has amino groups, a thiourea bridge is formed between the polymer and cofactor and a polymer having hydroxyl groups results in a thiocarbamate bridge. The polymer may be a copolymer of vinylamine or vinylmethylamine and vinylmethylacetamide, partially alkylamine-substituted .alpha., .beta.-poly-(2-hydroxyethyl)-D,L-aspartamide, polyethyleneimine or carbohydrate. The cofactor bound to a polymer and an enzyme are contained in microcapsules or in a membrane to form an enzyme reactor.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: April 21, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hubert Bader, Hans-Ullrich Hoppe, Michael Magerstadt, Merten Schlingmann, Dieter Ulschneider, Axel Walch
  • Patent number: 5028732
    Abstract: Compounds having the formula ##STR1## wherein Q is substituted phenyl or substituted pyridyl; Y is nitro, cyano, or halogen; R is a group of the formula --(CHR.sup.1).sub.m --A--(CH.sup.2)--.sub.n --R.sup.3 wherein R.sup.1 and R.sup.2, independently of each other and in each (CHR.sup.1) and (CHR.sup.2) group, are hydrogen, unsubstituted or substituted alkyl, alkoxy, or alkylthio; A is --N(R.sup.1)--, --N(O)--, --O--, --S--, --S(O)--, --S(O).sub.2 --, --C(O)--, --C(O)B--, or --N(H)S(O).sub.2 --; B is alkylene, --O--, --S--, or --N(R.sup.4)--; R.sup.3 is cyano, halogen, or C(O)Z; R.sup.4 is hydrogen or unsubstituted or substituted alkyl; Z is hydrogen, unsubstituted or substituted alkyl, --N(R.sup.4).sub.2, --OR.sup.5, --SR.sup.5, or --N(R.sup.4)SO.sub.2 R.sup.6 ; R.sup.5 is hydrogen, unsubstituted or substituted alkyl, or an agronomically-acceptable cation; R.sup.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: July 2, 1991
    Assignee: Rohm and Haas Company
    Inventors: Ann H. Beaulieu, Roy Y. Yih
  • Patent number: 4996201
    Abstract: 4-(N-Substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.
    Type: Grant
    Filed: August 2, 1989
    Date of Patent: February 26, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Stephen C. Bergmeier, Jeffrey A. Kester, Walter H. Moos, Haile Tecle, Anthony J. Thomas
  • Patent number: 4983630
    Abstract: There are provided new 2,2-difluorocyclopropylethane derivatives of general formula I ##STR1## in which A, B and R.sup.1-5 have the meanings given in the description and processes for their preparation. The compounds of the invention can be used as pesticides, especially against insects and mites.
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: January 8, 1991
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Wegner, Hartmut Joppien, Gunter Homberger, Arnim Kohn
  • Patent number: 4801721
    Abstract: Methods for the alkylation of substituted amines with trifluorate esters is disclosed.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: January 31, 1989
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4788287
    Abstract: A high performance water and oil repellant composed of a compound comprising at least two terminal segments and an intermediate segment connecting the terminal segments and having a molecular weight of from 800 to 20,000, each terminal segment containing at least one polyfluoroalkyl group connected by a --CONH-- linking group, said intermediate segment being a urethane oligomer containing at least two --CONH-- linking groups in one molecule, and said terminal segments and intermediate segment being connected by a --CONH-- linking group.
    Type: Grant
    Filed: September 3, 1986
    Date of Patent: November 29, 1988
    Assignee: Asahi Glass Company Ltd.
    Inventors: Masashi Matsuo, Masayuki Tamura, Katsuji Ito
  • Patent number: 4778915
    Abstract: The invention relates to fluoroacrylic monomers of formula: ##STR1## in which R.sub.f denotes a perfluoroalkyl radical, R is hydrogen or a methyl radical, R' denotes an alkyl or cycloalkyl radical, or --NR'-- denotes a 1, 4-piperazinylene radical, W and Z denote divalent connecting groups, Q is oxygen or sulphur or an --NR"-- group, R" denoting hydrogen an alkyl radical, and A is a C.sub.2 or C.sub.3 alkylene group. The polymers (homo- or copolymers) derived from these monomers may be used for the water-repellency and oil-repellency treatment of various substrates, particularly leather.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: October 18, 1988
    Assignee: Atochem
    Inventors: Marie-Jose Lina, Andre Dessaint
  • Patent number: 4761175
    Abstract: m-Anilido-urethanes of the formula ##STR1## where A and B independently of one another are oxygen or sulfur,R.sup.1 is alkyl, which is unsubstituted or substituted by halogen, alkoxy, alkoxycarbonyl or cyano, or is alkenyl which is unsubstituted or substituted by halogen, or is alkynyl which is unsubstituted or substituted by halogen or alkoxy, or is cycloalkyl which is unsubstituted or substituted by alkyl, or is aryl,R.sup.2 and R.sup.3 are each independently of one another hydrogen, alkyl, alkoxyalkyl or haloalkyl,R.sup.4 is alkylene of 1 to 6 carbon atoms which is unsubstituted or substituted by alkyl, alkoxyalkyl or haloalkyl,X is hydrogen, alkyl, haloalkyl, alkoxy, halogen, nitro or amino,Y is hydrogen, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl, halogen, alkoxy, haloalkoxy, alkylthio, nitro, aryl, thiocyanato, cyano, ##STR2## where R.sup.5 and R.sup.6 are each, independently of one another, hydrogen or have the meanings given for R.sup.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: August 2, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Schirmer, Rainer Becker, Bruno Wuerzer
  • Patent number: 4746717
    Abstract: An isocyanate-terminated sulfocompound is the reaction product of a polyisocyanate and a sulfopolyol or sulfopolyamine which is the reaction product of one mole of a sulfodicarboxylic acid and about two moles of an aliphatic polyol or polyamine having two or more hydroxyl or amino groups attached to a linear chain and having a molecular weight of up to 2000. The sulfocompound can be reacted with ethylenically-unsaturated alcohols, water, polyamines, or polyols, to give ethylenically-unsaturated sulfocompounds, sulfopolyureas or sulfopolyurethanes.
    Type: Grant
    Filed: January 22, 1987
    Date of Patent: May 24, 1988
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Wayne K. Larson
  • Patent number: 4725680
    Abstract: The invention relates to a process for preparing carbamic acid derivatives of formula: ##STR1## in which R.sup.1 or R.sup.2 denotes a hydrogen atom or a substituted or unsubstituted, saturated or unsaturated aliphatic, cycloaliphatic or heterocyclic radical, or R.sup.1 and R.sup.2 together form a ring, and Y denotes OR, SR, ##STR2## groups, R being a substituted or unsubstituted, saturated or unsaturated aliphatic or cycloaliphatic radical, or a substituted or unsubstituted aromatic radical, R.sup.3 and R.sup.4 denote a hydrogen atom or an aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical or together form a ring, and R.sup.6 and R.sup.7 denote a saturated or unsaturated, substituted or unsubstituted aliphatic or cycloaliphatic radical, a hydrogen atom, an alkylthio radical or an alkyloxy radical.According to the process, a compound of formula ##STR3## is reacted with an .alpha.-halogenated derivative of formula ##STR4## at a temperature of to C.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: February 16, 1988
    Assignee: Societe Nationale des Poudres et Explosifs
    Inventors: Gerard Barcelo, Jean-Pierre Senet, Gerard Sennyey
  • Patent number: 4692186
    Abstract: S-n-butyl-N,N-diisopropyl thiocarbamate which has the structural formula ##STR1## which is useful as a selective herbicide in sugarbeets, carrots and cabbage.
    Type: Grant
    Filed: October 1, 1982
    Date of Patent: September 8, 1987
    Assignee: Stauffer Chemical Co.
    Inventors: Reed A. Gray, Grant K. Joo
  • Patent number: 4684459
    Abstract: A collector composition for use in froth flotation processes comprises two collectors. One of the collectors is preferably an omega-(hydrocarbylthio)alkylamine, S-(omega-aminoalkyl) hydrocarbyl thioate, N-(hydrocarbyl)-alpha, omega-alkanediamine, (omega-aminoalkyl) hydrocarbon amide, omega-(hydrocarbyloxy)alkylamine, omega-aminoalkyl hydrocarbonoate or mixture thereof. The second collector is a thiocarbonate, a thionocarbamate, a thiophosphate, thiocarbinilide, thiophosphinate, mercaptan, xanthogen formate, xanthic ester or mixture thereof. The collector composition floats a broad range of metal-containing minerals.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: August 4, 1987
    Assignee: The Dow Chemical Company
    Inventors: Richard R. Klimpel, Robert D. Hansen
  • Patent number: 4676890
    Abstract: A collector composition useful for the recovery of metal values from metal ores in a froth flotation process comprises two collectors. One collector is an organic compound containing at least 4 carbon atoms and one or more monosulfide units, wherein the carbon atoms to which the sulfur atoms are bound are aliphatic or cycloaliphatic carbons. The other collector is preferably an omega-(hydrocarbylthio)alkylamine, S-(omega-aminoalkyl)hydrocarbyl thioate, N-(hydrocarbyl)-alpha, omega-alkanediamine, N-(omega-aminoalkyl)hydrocarbon amide, omega-(hydrocarbyloxy)alkalamine, omega-aminoalkyl hydrocarbonate or mixture thereof. The collector composition floats a broad range of metal values including sulfide ores, oxide ores and precious metals.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: June 30, 1987
    Assignee: The Dow Chemical Company
    Inventors: Richard R. Klimpel, Robert D. Hansen
  • Patent number: 4617416
    Abstract: There is disclosed a process for the preparation of thiocarbamates having the following general formula: ##STR1## wherein: R represents alkyl C.sub.1 -C.sub.4 optionally substituted with one or more halogen atoms, alkenyl C.sub.2 -C.sub.4 optionally substituted with one or more halogen atoms, phenyl optionally substituted with one or more halogen atoms, benzyl optionally substituted with one or more halogen atoms on the phenyl ring;R.sup.1 and R.sup.2, equal or different from one another, represent alkyl C.sub.1 -C.sub.4 or cycloalkyl;consisting in reacting organic dithiocarbonates with organic carbamoyl halides, in the presence of an aqueous solution of an inorganic base and a phase transfer catalyst, at a temperature of to C. for time periods of 5 to 10 hours.The thiocarbamates obtained are used as herbicides, fungicides, etc., and in general in various fields of "fine chemicals".
    Type: Grant
    Filed: March 19, 1985
    Date of Patent: October 14, 1986
    Assignee: Montedison S.p.A.
    Inventors: Renato Ugo, Stefano Campolmi, Vittorio Carletti
  • Patent number: 4613461
    Abstract: The invention relates to a new process for preparing known thiolcarbamate esters of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 stand independently for hydrogen or a straight or branched chain alkyl group containing 1 to 6 carbon atoms or an alkenyl group containing 2 to 6 atoms, or an alkyl group containing 1 to 6 or an alkenyl group containing 2 to 6 carbon atoms and mono- or polysubstituted by halogen, oxygen, sulphur and/or nitrogen; orR.sup.1 and R.sup.2 together may represent an optionally substituted .alpha.,.omega.-alkylene group containing 4 to 6 carbon atoms;R.sup.3 and R.sup.4 stand independently for hydrogen or an alkyl group containing 1 to 4 carbon atoms and optionally substituted by halogen or by a group containing oxygen, sulphur and/or nitrogen; andR.sup.5 and R.sup.6 both stand for hydrogen; orR.sup.5 and R.sup.6 together may represent a chemical bond.
    Type: Grant
    Filed: December 31, 1984
    Date of Patent: September 23, 1986
    Assignees: MTA Kozponti Kemiai Kutato Intezet, Borsodi Vegyi Kombinat
    Inventors: Peter Viski, Laszlo Simandi, Ferenc Nagy, Gabor Besenyei, Gyorgy Paszthy, Gyula Pazmandi, Istvan Szita, Gyula Szilagyi, Istvan Toth, Ilona Szigeti nee Kiss