Cyanoalkylation Of An Acyclic Or Alicyclic Carbon, Which Is Adjacent To A Benzene Ring Or An Atom Double Or Triple Bonded To A Non-carbon Atom, By Means Of Acrylonitrile Or Hydrocarbyl-substituted Acrylonitrile (e.g., Cyanoethylation, Etc.) Patents (Class 558/367)
  • Publication number: 20140128598
    Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
    Type: Application
    Filed: November 6, 2013
    Publication date: May 8, 2014
    Inventors: Maria Del Pilar CARRANZA, Maria Isabel GARCIA ARANDA, José Lorenzo GONZALEZ, Frédéric SANCHEZ
  • Publication number: 20100010216
    Abstract: The invention provides a 2-fluorinated acyl-3-aminoacrylonitrile derivative, and a method for producing the same. A desired 2-fluorinated acyl-3-aminoacrylonitrile derivative represented by the following Formula (3) is obtained by reacting a fluorinated acyl derivative with an aminoacrylonitrile derivative. In Formula (3), Rf represents an alkyl group having 1 to 6 carbon atoms which is substituted with at least one fluorine atom, R1 and R2 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like, and R3 represents an alkyl group having 1 to 6 carbon atoms or the like.
    Type: Application
    Filed: December 18, 2007
    Publication date: January 14, 2010
    Applicant: Mitsui Chemicals Agro, INC
    Inventors: Hideki Umetani, Yoji Aoki, Takeshi Kakimoto
  • Publication number: 20030061670
    Abstract: Process for preparing compounds of the formula (I) 1
    Type: Application
    Filed: August 19, 2002
    Publication date: April 3, 2003
    Inventors: Josef-Walter Stawitz, Stephan Michaelis, Christoph Thiebes
  • Patent number: 6472553
    Abstract: Compounds of the structure: wherein R1 is H, a C1 to C4 alkyl, or a substituted C1 to C4 alkyl; R2 is H or a cyanoethyl; n is an integer of 1 to 4, and y is 1 or 2, and a method for making the compounds. The compounds are made by reacting acrylonitrile with one or more cycloaliphatic vicinal diamines in the presence of water and a catalytic amount of an acid catalyst having a pKa of −3.0 to 7.5.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: October 29, 2002
    Assignee: Air Products and Chemicals, Inc.
    Inventor: Juan Jesus Burdeniuc
  • Patent number: 6245932
    Abstract: A process for the cyanoethylation of substituted cycloaliphatic vicinal diamines which comprises reacting acrylonitrile and a diamine in the presence water as catalyst. Cyanoethylated methylcyclohexylamines are readily prepared in the presence of water.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: June 12, 2001
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Juan Jesus Burdeniuc, Gamina Ananda Vedage
  • Patent number: 5399706
    Abstract: Imidazolidinone compounds of the formula: ##STR1## where R is a C.sub.3 -C.sub.5 alkylene group, R.sup.1 and R.sup.2 are independently H or C(.dbd.O)R.sup.4, R.sup.3 is an aliphatic hydrocarbon group optionally substituted with one or more alkoxy groups or interrupted by one or more ether oxygen atoms, and R.sup.4 is a hydrocarbon group substituted with an active hydrogen functional group are useful as chain extending monomers providing pendant imidazolidinone functionality to polyurethane/urea and epoxy polymers. The subject imidazolidinone compounds may also be incorporated into polyester/polyamide polyols or reacted to prepare radically polymerizable ethylenically unsaturated monomer and prepolymer compounds used in the synthesis of emulsion polymers.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: March 21, 1995
    Assignee: H. B. Fuller Licensing & Financing, Inc.
    Inventor: Michael J. Dochniak