Nitriles (i.e., Compounds Having Cyano Bonded Directly To Carbon, Which Carbon May Be Single Bonded To Any Atom But May Be Multiple Bonded Only To Carbon) Patents (Class 558/303)
  • Patent number: 9688840
    Abstract: An adhesive composition is provided which is excellent in adhesion rate on non-polar hard-to-bond materials and bond gap curability, and further is good in storage stability. It is a 2-cyanoacrylate-based adhesive composition which includes (a) a 2-cyanoacrylic acid ester and (b) an onium salt represented by the following general formula (1): nC+A?n-X??(1) wherein, in formula (1), C+ represents an onium cation, A? represents at least one anion selected from the group consisting of —SO3?, —OSO3? and a specific imide anion, X represents a linking group which connects at least two anions together, and n is an integer of 2 or more.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 27, 2017
    Assignee: TOAGOSEI CO., LTD.
    Inventors: Kenichi Ishizaki, Yushi Ando
  • Patent number: 9024056
    Abstract: The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3-methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9±0.1, 19.2±0.1, 20.0±0.1, 22.5±0.1, 23.2±0.1, 25.7±0.1, 28.1±0.1, 29.9±0.1, and 30.6±0.1 degrees 2?, and wherein the most intense peak is the peak at 13.9±0.1 degrees 2?.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 5, 2015
    Assignee: Olatec Industries LLC
    Inventors: Joseph P. St. Laurent, Gerald S. Jones, David M. Bresse
  • Patent number: 8912124
    Abstract: The invention relates to derivatives of (1-cyanocyclopropyl)phenylphosphinic acid of the formula (I) and to salts thereof, of the formula (II), for enhancing stress tolerance in plants to abiotic stress, preferably to drought stress, especially for enhancing plant growth and/or for increasing plant yield.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: December 16, 2014
    Assignee: Bayer Cropscience AG
    Inventors: Lothar Willms, Hans-Joachim Zeiβ, Marco Busch, Christopher Hugh Rosinger, Ines Heinemann, Isolde Häuser-Hahn, Martin Jeffrey Hills, Pascal Von Koskull-Döring
  • Patent number: 8901170
    Abstract: Compounds of formula (I) wherein the symbols have the meaning given in the specification, as well as processes for preparing the compounds (I), pesticidal compositions and synergistic mixtures comprising compounds (I), methods for the control of insects, acarids or nematodes by contacting the pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of compounds formula (I), and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a parasiticidally effective amount of compounds of formula (I).
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: December 2, 2014
    Assignee: BASF SE
    Inventors: Matthias Pohlman, Michael Hofmann, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Hassan Oloumi-Sadeghi, Takeo Hokama, Christopher Palmer
  • Patent number: 8816119
    Abstract: The invention relates to novel arylamide derivatives having formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, where R1-R11, R?, R?, z and X are as defined in the claims. The arylamide derivatives of formula (I) have antiandrogenic properties. The invention also relates to compounds of formula (I) for use as a medicament and to pharmaceutical compositions comprising them and to their preparation.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: August 26, 2014
    Assignee: Medeia Therapeutics Ltd
    Inventors: Jari Ratilainen, Milla Koistinaho, Anu Muona
  • Patent number: 8802885
    Abstract: The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3-methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9±0.1, 19.2±0.1, 20.0±0.1, 22.5±0.1, 23.2±0.1, 25.7±0.1, 28.1±0.1, 29.9±0.1, and 30.6±0.1 degrees 2?, and wherein the most intense peak is the peak at 13.9±0.1 degrees 2?.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: August 12, 2014
    Assignee: Olatec Industries LLC
    Inventors: Joseph P. St. Laurent, Gerald S. Jones, David M. Bresse
  • Patent number: 8785675
    Abstract: It is an object of the present invention to provide a mixed catalyst for a vapor-phase catalytic oxidation or a vapor-phase catalytic ammoxidation reaction of propane, or isobutene, capable of providing a corresponding unsaturated acid or unsaturated nitrile at high yield from propane or isobutene.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: July 22, 2014
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Takaaki Kato, Minoru Kadowaki
  • Patent number: 8686105
    Abstract: This invention relates to adhesive systems using imines and salts thereof, precursors to electron deficient olefins and coreactants therefor.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: April 1, 2014
    Assignee: Henkel IP & Holding GmbH
    Inventors: Ciaran B. McArdle, Ligang Zhao
  • Patent number: 8642501
    Abstract: Disclosed is a complex oxide catalyst composed of catalyst particles containing Mo, V, a component X and a silica-containing carrier. The component X is at least one element selected from alkaline earth metal elements and rare earth elements. The complex oxide catalyst is supported by the carrier, and the component X is uniformly distributed in the catalyst particles.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: February 4, 2014
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Takaaki Kato, Satoshi Fukushima
  • Patent number: 8574534
    Abstract: The invention is directed to a method for producing a film of porous carbon, the method comprising carbonizing a film of an ionic liquid, wherein the ionic liquid has the general formula (X+a)x(Y?b)y, wherein the variables a and b are, independently, non-zero integers, and the subscript variables x and y are, independently, non-zero integers, such that a·x=b·y, and at least one of X+ and Y? possesses at least one carbon-nitrogen unsaturated bond. The invention is also directed to a composition comprising a porous carbon film possessing a nitrogen content of at least 10 atom %.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: November 5, 2013
    Assignee: UT-Battelle, LLC
    Inventors: Sheng Dai, Huimin Luo, Je Seung Lee
  • Patent number: 8507493
    Abstract: The present invention relates to inhibitors of 11-?-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: August 13, 2013
    Assignee: AbbVie Inc.
    Inventors: Sridhar Peddi, Meena V. Patel, Jeffrey J. Rohde
  • Patent number: 8367078
    Abstract: The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating disorders, especially cancer.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: February 5, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Peter P. Sayeski, György M. Keserü
  • Patent number: 8309751
    Abstract: The present invention relates to a process for preparing ?-ketonitriles of the general formula I in which R1 is, inter alia, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl; R2 is, inter alia, hydrogen, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, which comprises reacting a nitrile of the formula II in which R1 has one of the meanings given above with a carboxylic ester of the formula III in which R2 has one of the meanings given above and R3 is C1-C12-alkyl, C1-C4-alkoxy -C1-C4-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy -C1-C4-alkyl or benzyloxy-C1-C4-alkyl, where the reaction is carried out in the presence of a potassium alkoxide and at least 80% of the nitrile of the formula II are added to the reaction under reaction
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: November 13, 2012
    Assignee: BASF SE
    Inventors: Uwe Josef Vogelbacher, Peter Otto, Michael Rack
  • Patent number: 8273467
    Abstract: An organic electroluminescent device, which comprises: a pair of electrodes; and an organic compound layer including a light-emitting layer between the pair of electrodes, wherein the organic compound layer comprises a compound represented by formula (I): wherein Z1, Z2, Z3 and Z4 each independently represents an atom selected from the group consisting of carbon, nitrogen, sulfur and oxygen and necessary for forming an unsaturated 6-membered ring skeleton, the atom may have a hydrogen atom or a substituent; a bond in the unsaturated 6-membered ring indicates a single bond or a double bond; and R1 represents a substituent.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: September 25, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Satoshi Sano, Tatsuya Igarashi, Masaru Kinoshita
  • Patent number: 8258335
    Abstract: The present invention relates to a process for preparing hydrochloride-free 2-dihaloacyl-3-aminoacrylic esters by reacting acid fluorides with dialkylaminoacrylic acid derivatives.
    Type: Grant
    Filed: September 13, 2008
    Date of Patent: September 4, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Sergii Pazenok, Norbert Lui
  • Patent number: 8247612
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods represented by the formula (I): wherein, R1 represents a C1-C5 haloalkyl group having at least one fluorine atom, R2 represents a C1-C4 alkyl group optionally substituted with at least one halogen atom or the like, R3 represents a hydrogen atom or the like, R4 represents a cyano group or the like, R5 represents a hydrogen atom or the like, m represents an integer of 1 to 4, and n represents 0, 1 or 2.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: August 21, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Miyazaki
  • Patent number: 8106230
    Abstract: The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic acid diester of the formula (2): wherein R1 is an amino group protected with a group removed by hydrogenolysis or a tert-butoxycarbonylamino group and R2 is an ethyl group optionally substituted with one or two methyl group(s) at ?-position, provided that R2 is not a tert-butyl group when R1 is a tert-butoxycarbonylamino group; with alkali metal alkoxide and the compound (3) can be an important intermediate for production of ranirestat.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: January 31, 2012
    Assignees: Dainippon Sumitomo Pharma Co., Ltd., Katayama Seiyakusyo Co., Ltd.
    Inventors: Takashi Inagaki, Yoshikazu Yamakawa
  • Patent number: 8034968
    Abstract: Disclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula 4 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; and X is Br, Cl or I.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: October 11, 2011
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Gary David Annis
  • Publication number: 20110229401
    Abstract: The invention is directed to a method for producing a film of porous carbon, the method comprising carbonizing a film of an ionic liquid, wherein the ionic liquid has the general formula (X+a)x(Y?b)y, wherein the variables a and b are, independently, non-zero integers, and the subscript variables x and y are, independently, non-zero integers, such that a·x=b·y, and at least one of X+ and Y? possesses at least one carbon-nitrogen unsaturated bond. The invention is also directed to a composition comprising a porous carbon film possessing a nitrogen content of at least 10 atom %.
    Type: Application
    Filed: March 18, 2010
    Publication date: September 22, 2011
    Applicant: UT-BATTELLE, LLC
    Inventors: Sheng Dai, Huimin Luo, Je Seung Lee
  • Publication number: 20110174179
    Abstract: There is provided a lithographic printing plate precursor that enables image recording using a laser and that provides an excellent scumming resistance and an excellent developability while maintaining a satisfactory printing durability. Also provided are a platemaking method, and a novel polymerizable monomer. A lithographic printing plate precursor has a support, and an image recording layer disposed thereon and containing a radical polymerization initiator and a polymerizable monomer that has a sulfonamide group and at least two ethylenically unsaturated groups; a lithographic printing plate platemaking method uses this lithographic printing plate precursor; and a polymerizable monomer has a sulfonamide group and at least two ethylenically unsaturated groups.
    Type: Application
    Filed: September 30, 2009
    Publication date: July 21, 2011
    Inventors: Katsuhiro Shimono, Norio Aoshima, Junji Kawaguchui
  • Patent number: 7964635
    Abstract: The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: June 21, 2011
    Assignee: Novartis AG
    Inventors: Noëlle Gauvry, Thomas Goebel, Pierre Ducray, François Pautrat, Ronald Kaminsky, Martin Jung
  • Patent number: 7914707
    Abstract: Disclosed is a compound represented by the following formula 1: wherein, each of R1˜R13 independently represents —H, —F, —Cl, —Br, —I, —OH, —SH, —COOH, —PO3H2, —NH2, —NO2, —O(CH2CH2O)nH (wherein, n is an integer of 1˜5), C1˜C12 alkyl group, C1˜C12 aminoalkyl group, C1˜C12 hydroxyalkyl group, C1˜C12 haloalkyl group, C2˜C12 alkenyl group, C1˜C12 alkoxy group, C1˜C12 alkylamino group, C1˜C12 dialkylamino group, C6˜C18 aryl group, C6˜C18 aminoaryl group, C6˜C18 hydroxyaryl group, C6˜C18 haloaryl group, C7˜C18 benzyl group, C7˜C18 aminobenzyl group, C7˜C18 hydroxybenzyl group, C7˜C18 halobenzyl group, or nitrile group (—CN); and at least one of R4˜R13 is nitrile group (—CN). A non-aqueous electrolyte comprising: (i) a lithium salt, (ii) a solvent, and (iii) a compound represented by formula 1; and a secondary battery comprising the non-aqueous electrolyte are also disclosed.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: March 29, 2011
    Assignee: LG Chem, Ltd.
    Inventors: Yu Sin Kim, Hyeong Jin Kim, Hye Yun Cha, Ho Chun Lee
  • Patent number: 7893292
    Abstract: Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is optionally interrupted by —O— or by —NR7—; R4 is a cyano group; or -Q1-R5; Q1 is —COO—; —CONH—; —CO—; —SO2—; or —CONR6—; R5 is C1-C22alkyl; cyclo-C3-C8alkyl; or unsubstituted or C1-C6alkyl-substituted C6-C20aryl; R6 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; R7 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; the cyclohexene radical C is not substituted or substituted by one or more C1-C5alkyl; m is from 3 to 7; n is from 2 to 4; and o is from 2 to 4.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: February 22, 2011
    Assignee: BASF SE
    Inventors: Barbara Wagner, Thomas Ehlis, Stefan Müller
  • Patent number: 7893099
    Abstract: The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: February 22, 2011
    Assignee: Hoffman-La Roche Inc.
    Inventors: David Banner, Simona M. Ceccarelli, Uwe Grether, Wolfgang Haap, Hans Hilpert, Holger Kuehne, Harald Mauser, Jean-Marc Plancher, Ruben Alvarez Sanchez
  • Publication number: 20100267738
    Abstract: The present invention relates to inhibitors of 11-?-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
    Type: Application
    Filed: April 20, 2010
    Publication date: October 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Sridhar Peddi, Meena V. Patel, Jeffrey J. Rohde
  • Patent number: 7807616
    Abstract: A fragrance preparation containing 3,7-dimethyloct-6-enenitrile and other compounds described herein is a geranonitrile substitute which has the advantages inherent to geranonitrile, such as fragrance freshness and composition stability but is less objectionable from a toxicological standpoint.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: October 5, 2010
    Assignee: Henkel AG & Co. KGaA
    Inventors: Georg Meine, Theo ten Pierik
  • Publication number: 20100239678
    Abstract: The present invention is directed to attaching drugs 11 and other functional groups to surfaces of nano-sized diamond particles (NDs) 20 to enhance their efficacy. The method involves hydrating a plurality of nanodiamond (ND) particles 20 having a plurality of carbon chain surface molecules 23 on its surface. Cations 40 are embedded within the lattice structure 21 of the surface molecules 23 of the ND particles 20. The embedded cations 40 attract anions that cause crystalline growth. The anion form of drug molecules 11 are then grown on the crystal to cause the NDs 20 to be coated such that the active sites of said drug molecules 11 point away from the ND particle 20 exposing them for enhanced activity and enhanced drug efficacy. The efficacy of antimicrobial drugs 11, as well as other drugs 11 are enhanced by their attachment to the NDs 20.
    Type: Application
    Filed: June 7, 2010
    Publication date: September 23, 2010
    Inventor: Ali RAZAVI
  • Patent number: 7709659
    Abstract: Tetraphosphorous ligands are combined with transition metal salts to form catalysts for use in hydroformylation, isomerization-hydroformylation, hydrocarboxylation, hydrocyan-ation, isomerization-formylation, hydroaminomethylation and similar related reactions.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: May 4, 2010
    Assignee: The Penn State Research Foundation
    Inventors: Xumu Zhang, Yongjun Yan
  • Publication number: 20100105903
    Abstract: The present invention relates to a process for preparing ?-ketonitriles of the general formula I in which R1 is, inter alia, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl; R2 is, inter alia, hydrogen, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, which comprises reacting a nitrile of the formula II in which R1 has one of the meanings given above with a carboxylic ester of the formula III in which R2 has one of the meanings given above and R3 is C1-C12-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, where the reaction is carried out in the presence of a potassium alkoxide and at least 80% of the nitrile of the formula II are added to the reaction under reaction
    Type: Application
    Filed: February 29, 2008
    Publication date: April 29, 2010
    Applicant: BASF SE
    Inventors: Uwe Josef Vogelbacher, Peter Otto, Michael Rack
  • Patent number: 7705047
    Abstract: The invention relates to compounds of the general formula wherein either R signifies C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C2-C6-alkyl or halo-C1-C6-alkoxy-halo-C2-C6-alkyl; and X1 signifies a single bond, O, S, S(O) or S(O)2; or R signifies halogen and X1 signifies a single bond; X2 signifies CN, halogen, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-alkylsulfonylamino, halo-C1-C6-alkylsulfonylamino, OH, NH2, COOH, CONH2, C1-C6-alkylaminocarbonyl or C1-C6-alkylcarboxamido, whereby if n is greater than 1, X2 may differ from each other; m signifies 1, 2, 3 or 4; and n is 1, 2, 3, 4 or 5, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: April 27, 2010
    Assignee: Novartis AG
    Inventors: Thomas Goebel, Noëlle Gauvry, Pierre Ducray
  • Publication number: 20100076203
    Abstract: The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic acid diester of the formula (2): wherein R1 is an amino group protected with a group removed by hydrogenolysis or a tert-butoxycarbonylamino group and R2 is an ethyl group optionally substituted with one or two methyl group(s) at ?-position, provided that R2 is not a tert-butyl group when R1 is a tert-butoxycarbonylamino group; with alkali metal alkoxide and the compound (3) can be an important intermediate for production of ranirestat.
    Type: Application
    Filed: August 30, 2007
    Publication date: March 25, 2010
    Inventors: Takashi Inagaki, Yoshikazu Yamakawa
  • Patent number: 7674819
    Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: March 9, 2010
    Assignee: Warner-Lambert Company LLC
    Inventors: Stephen Douglas Barrett, Victor Fedij, Lain-Yen Hu, Donna M. Iula, Bruce A. Lefker, Raj Kumar Raheja, Karen Sexton, Jennifer Ann Van Camp
  • Patent number: 7649018
    Abstract: Compounds of formula II wherein each R1 and R2 is independently selected from H and —P(O)(R3)(R4), provided that at least one of R1 and R2 is —P(O)(R3)(R4); each R3 and R4 is independently selected from the group consisting of H, —OH, C1-C6 alkyl, and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising a compound of formula II, and methods of administering such compounds and compositions.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: January 19, 2010
    Assignee: Wyeth LLC
    Inventors: Mahdi B. Fawzi, Parimal R. Desai, Tianmin Zhu
  • Publication number: 20090270470
    Abstract: Compounds of formula I, wherein R1, Z, X, Y, M and R2 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical composition containing the same, methods of using the same for therapeutic purposes and methods of making the same.
    Type: Application
    Filed: May 8, 2006
    Publication date: October 29, 2009
    Applicant: AstraZeneca AB
    Inventors: Catrin Jonasson, Hakan Molin, Berit Molin, Didier Rotticci
  • Patent number: 7608604
    Abstract: The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R1, R2, R3, R4 and R5 are each independently selected from H, halo, CN, CF3 and CONH2; compositions containing such compounds and the uses of such compounds as antiparasitic agents.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: October 27, 2009
    Assignee: Pfizer Limited
    Inventors: Stuart Nicholas Comlay, Joanne Clare Hannam, William Howson, Christelle Lauret, Yogesh Anil Sabnis
  • Publication number: 20090253656
    Abstract: The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 represents a cyano group and the other represents a hydrogen atom; Ar1 represents a group selected from among the groups represented by formulas (2) to (4): and Ar2 represents an aromatic hydrocarbon group having a condensed ring which may be substituted by a halogen atom, or a group selected from among the groups represented by the following formulas (5) to (15): or a salt thereof.
    Type: Application
    Filed: March 29, 2006
    Publication date: October 8, 2009
    Applicant: Kabushiki Kaisha Yakult Honsha
    Inventors: Ryuta Yamazaki, Yukiko Nishiyama, Tomio Furuta, Takeshi Matsuzaki, Hiroshi Hatano, Oh Yoshida, Masato Nagaoka, Ritsuo Aiyama, Shusuke Hashimoto, Yoshikazu Sugimoto
  • Patent number: 7579494
    Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: August 25, 2009
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Charles N. Serhan
  • Patent number: 7572930
    Abstract: The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: August 11, 2009
    Assignee: Chemagis Ltd.
    Inventors: Yanling Wang, Yuang Wang, Michael Brand, Joseph Kaspi
  • Publication number: 20090198071
    Abstract: Tetraphosphorous ligands are combined with transition metal salts to form catalysts for use in hydroformylation, isomerization-hydroformylation, hydrocarboxylation, hydrocyan-ation, isomerization-formylation, hydroaminomethylation and similar related reactions.
    Type: Application
    Filed: April 17, 2009
    Publication date: August 6, 2009
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Xumu ZHANG, Yongjun Yan
  • Publication number: 20090196909
    Abstract: There is disclosed an article and method of making an article for removing at least one contaminant from a solid surface. In one embodiment, the article comprises carbon nanotubes attached to a support media, such as a nonwoven mixture of PET and cotton. There is also disclosed a method of removing at least one contaminant from a solid surface, such as areas where microbial, particle, or static contamination is undesirable, including hospitals, clean rooms, kitchens, baths, or human hands.
    Type: Application
    Filed: October 22, 2008
    Publication date: August 6, 2009
    Inventors: Christopher H. Cooper, Whitmore B. Kelley, JR., Vardhan Bajpai, Daniel Iliescu, Thomas H. Treutler, Andrei Burnin, Hai-Feng Zhang
  • Publication number: 20090171109
    Abstract: The present invention relates to an integrated process for producing unsaturated carboxylic acids from the corresponding C2-C4 alkane. The process begins with performance of thermally integrated dehydrogenation reactions which convert a C2-C4 alkane to its corresponding C2-C4 alkene, and which involve exothermically converting a portion of an alkane to its corresponding alkene by oxidative dehydrogenation in an exothermic reaction zone, in the presence of oxygen and a suitable catalyst, and then feeding the products of the exothermic reaction zone to an endothermic reaction zone wherein at least a portion of the remaining unconverted alkane is endothermically dehydrogenated to form an additional quantity of the same corresponding alkene, in the presence of carbon dioxide and an other suitable catalyst.
    Type: Application
    Filed: December 11, 2008
    Publication date: July 2, 2009
    Inventors: Abraham Benderly, Nitin Chadda, Douglass Sevon
  • Publication number: 20090149548
    Abstract: The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases.
    Type: Application
    Filed: February 11, 2009
    Publication date: June 11, 2009
    Applicant: Welichem Biotech, Inc.
    Inventors: Genhui Chen, John Webster, Jianxiong Li, Wei Liu
  • Patent number: 7544828
    Abstract: A process for preparation of Bicalutamide of formula (I), comprising oxidation of compound of formula (II), with potassium permanganate in presence of water or a mixture of water and water miscible solvent and isolating Bicalutamide of formula (I) thereof.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: June 9, 2009
    Assignee: Dabur Pharma Limited
    Inventors: Anil Kumar Shukla, Golak Chandra Maikap, Shiv Kumar Agarwal
  • Patent number: 7541486
    Abstract: A process is described for preparing 3-pentenenitrile, characterized by the following process steps: (a) reacting 1,3-butadiene with hydrogen cyanide over at least one catalyst to obtain a stream 1 which comprises 3-pentenenitrile, 2-methyl-3-butenenitrile, the at least one catalyst and 1,3-butadiene, (b) distilling stream 1 in a column to obtain a high-1,3-butadiene stream 2 as the top product and a low-1,3-butadiene stream 3 as the bottom product which comprises 3-pentenenitrile, the at least one catalyst and 2-methyl-3-butenenitrile, (c) distilling stream 3 in a column to obtain a stream 4 as the top product which comprises 1,3-butadiene, a stream 5 which comprises 3-pentenenitrile and 2-methyl-3-butenenitrile at a side draw of the column, and a stream 6 as the bottom product which comprises the at least one catalyst, (d) distilling stream 5 to obtain a stream 7 as the top product which comprises 2-methyl-3-butenenitrile, and a stream 8 as the bottom product which comprises 3-pentenenitrile.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: June 2, 2009
    Assignee: BASF Aktiengesellschaft
    Inventors: Jens Scheidel, Tim Jungkamp, Michael Bartsch, Gerd Haderlein, Robert Baumann, Hermann Luyken
  • Patent number: 7504528
    Abstract: Described are merocyanine derivatives of formula (1a) or (1b) wherein n and o are integers from 2 to 4 and aminocyclohexenone intermediates. They are used in protecting human and animal hair and skin from UV radiation.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: March 17, 2009
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Barbara Wagner, Thomas Ehlis, Stefan Müller
  • Patent number: 7494956
    Abstract: The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: February 24, 2009
    Assignee: Novartis AG
    Inventors: Noëlle Gauvry, Thomas Goebel, Pierre Ducray, François Pautrat, Ronald Kaminsky, Martin Jung
  • Patent number: 7473711
    Abstract: The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker
  • Patent number: 7468453
    Abstract: A process for the preparation of gamma-cyahlothrin comprising a) chlorinating 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid to give 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride; b) esterifying 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride with 3-phenoxy benzaldehyde in the presence of a source of cyanide to form a diastereoisomeric mixture of cyhalothrin isomers and c) epimerising the diastereoisomeric mixture under conditions in which the least soluble diastereoisomer crystallises from solution.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: December 23, 2008
    Assignee: Syngenta Limited
    Inventors: Stephen Martin Brown, Brian David Gott
  • Publication number: 20080303885
    Abstract: An inkjet ink composition includes a colorant, water, and a dicyanobenzene-based compound, and an ink set including the same.
    Type: Application
    Filed: February 1, 2008
    Publication date: December 11, 2008
    Applicant: Samsung Electronics Co., Ltd.
    Inventor: Yeon-kyoung JUNG
  • Patent number: 7425580
    Abstract: The present invention concerns compounds of formula: where R1, R2, R3 and R4 are defined in the specification.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: September 16, 2008
    Assignee: Wyeth
    Inventors: Thomas Joseph Caggiano, Antony Aldo Brazzale