Benzene Ring Bonded Directly To The Carbonyl Patents (Class 558/415)
  • Patent number: 10189791
    Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: January 29, 2019
    Assignee: Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Gordon W. Gribble
  • Patent number: 9969677
    Abstract: The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: May 15, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Yitshak Francis, Mauro Fa, Ottavio Arancio, Jole Fiorito, Shixian Deng, Donald W. Landry, Michal Luzac, Yan Feng
  • Patent number: 9896475
    Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a tnterpenoid compound of Formula I, or a hydrate, isomer, prodrug or pharmaceutically acceptable salt thereof: wherein one or more of R, R or R is independently a substituted or unsubstituted aryl group, heteroaryl group, cycloalkyl group or heterocyclyl group, and the remaining R groups are hydrogen. The pyridyl analogs of CD-DO-1m 1 have been developed, which are more stable in human plasma and achieve a higher concentration in target tissues such as liver, pancreas, kidney and lungs.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: February 20, 2018
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Gordon W. Gribble, Michael B. Sporn, Karen T. Liby, Evans O. Onyango, Martine Cao
  • Patent number: 9290455
    Abstract: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid amino acid derivatives having antiinflammatory properties are provided. Pharmaceutical compositions and methods for preventing or treating inflammation or a disease or condition mediated by inflammation are described.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 22, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Martine Cao, Evans O. Onyango, Liangfeng Fu, Gordon W. Gribble
  • Publication number: 20150051199
    Abstract: The invention provides compounds that are useful in the treatment of hepatitis C virus (HCV) infections.
    Type: Application
    Filed: October 31, 2012
    Publication date: February 19, 2015
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Andrew James Woodhead, Christopher Charles Frederick Hamlett, Gilbert Ebai Besong, Gianni Chessari, Maria Grazia Carr, Alessia Millemaggi, David Norton, Susanne Maria Saalau-Bethell, Hendrika Maria Gerarda Willems, Neil Thomas Thompson, Steven Douglas Hiscock
  • Patent number: 8946478
    Abstract: Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: February 3, 2015
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Hua Bai, Xuyang Zhao, Yongxiang Gong, Jinqing Zhong, Qifeng Zhu, Xiaoyu Liu, Lifei Liu, Qixian Zhou
  • Publication number: 20140303377
    Abstract: An object of the present invention is to provide insecticides having high effectiveness.
    Type: Application
    Filed: June 24, 2014
    Publication date: October 9, 2014
    Inventors: Kei Yoshida, Takeo Wakita, Hiroyuki Katsuta, Akiyoshi Kai, Yutaka Chiba, Kiyoshi Takahashi, Hiroko Kato, Nobuyuki Kawahara, Michikazu Nomura, Hidenori Daido, Junji Maki, Shinichi Banba, Atsuko Kawahara
  • Publication number: 20140274692
    Abstract: A compound of formula (I) wherein R1 to R4 are, for example, each hydrogen, R5 is, for example, a substituted phenol; R6 is, for example, hydrogen; R7 is, for example, hydrogen, cyano, hydroxyl, formyl, C1-C4-alkyl, C1-C4-alkoxy, C2-C4-alkenyl, or C2-C4-alkynyl; and A1 to A5 is, for example, A1 is N or C—X, A3 is C—X, and A2, A4 and A5 are C—H, where X, is, for example, halogen; and its use as a pesticidal agent.
    Type: Application
    Filed: October 31, 2012
    Publication date: September 18, 2014
    Applicant: Syngenta Participations AG
    Inventors: Olivier Loiseleur, Thomas Pitterna, Anthony Cornelius O'Sullivan, Torsten Luksch, Anna Kickova
  • Patent number: 8822524
    Abstract: Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of the GSK-3 creating a hybrid peptide-non-peptide and non-peptide compounds capable of binding to Akt. The non-peptide compounds show increased stability and rigidity compared to peptide counterparts and are less susceptible to degradation. The bound non-peptide compounds exhibit an inhibitory effect on Akt, similar to peptide-based Akt inhibitors.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: September 2, 2014
    Assignees: University of South Florida, Yale University
    Inventors: Said M. Sebti, Jin Q. Cheng, Andrew D. Hamilton, Katherine Kayser-Bricker
  • Publication number: 20140217325
    Abstract: The present invention relates to liquid-crystalline media and to high-frequency components comprising same, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, in particular for microwave phased-array antennas.
    Type: Application
    Filed: August 7, 2012
    Publication date: August 7, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Atsutaka Manabe, Dagmar Klass
  • Publication number: 20140213598
    Abstract: Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agriculture and effectively prevents against a variety of pathogens such as cucumber downy mildew, wheat powdery mildew, maize rust disease, rice blast and cucumber gray mold. In particular, even at a low dose, the compound effectively prevents and treats rice blast, cucumber gray mold, maize rust disease and cucumber downy mildew. Moreover, the raw materials for preparing the compounds are widely available and the synthesis method therefor is simple and convenient.
    Type: Application
    Filed: June 15, 2012
    Publication date: July 31, 2014
    Applicants: SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD., SINOCHEM CORPORATION
    Inventors: Changling Liu, Guang Huang, Jie Lan, Shulin Hao, Zhinian Li, Huichao Li, Aiying Guan, Airu Jiang, Ying Xu
  • Publication number: 20140200239
    Abstract: The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.
    Type: Application
    Filed: August 3, 2012
    Publication date: July 17, 2014
    Applicant: National Taiwan University
    Inventors: Chung-Wai Shiau, Kuen-Feng Chen
  • Patent number: 8759564
    Abstract: Novel amidoacetonitrile compounds and compositions containing the compounds are disclosed. The compounds have pesticidal properties and are suitable for controlling endoparasites on warm-blooded animals.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: June 24, 2014
    Assignee: Novartis AG
    Inventors: Thomas Goebel, Noëlle Gauvry, Heinz Sager
  • Publication number: 20140171503
    Abstract: Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R1 to R5 and X1 to X5 are as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.
    Type: Application
    Filed: June 15, 2012
    Publication date: June 19, 2014
    Applicants: Human Services
    Inventors: Jane B. Neckers, Yeong Sang Kim, Sunmin Lee, Vineet Kumar, Sanjay V. Malhotra
  • Publication number: 20140148611
    Abstract: The present invention relates to a process for preparing 2-amino-5-cyano-N,3-dimethylbenzamide of formula (1) by reacting 2-amino-5-cyano-3-methylbenzoic esters or diesters with methylamine.
    Type: Application
    Filed: July 5, 2012
    Publication date: May 29, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Frank Volz, Thomas Himmler, Thomas Norbert Müller, Sandra Lehmann, Sascha Von Morgenstern, Wahed Ahmed Moradi, Sergii Pazenok, Norbert Lui
  • Patent number: 8716285
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The present invention is also directed to processes for making said compounds and uses of said compounds, in particular their use as medicaments, more particularly their use as medicaments in the treatment of cancer.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: May 6, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Guozhi Tang, Zhanguo Wang, Jason Christopher Wong, Weixing Zhang
  • Publication number: 20140113012
    Abstract: The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.
    Type: Application
    Filed: March 26, 2012
    Publication date: April 24, 2014
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Peter Schultz, Laure Bouchez
  • Publication number: 20140018566
    Abstract: A new method of ortho-fluorination for selectively fluorinating a benzoic acid or derivative compound where an aryl C—H bond is directly replaced by an aryl C—F bond is provided. The method comprises reacting a compound having the formula: wherein X is at least one substitution group attached with a benzene ring and Ar is an aromatic substitution group comprising at least one fluorine atom, and a mixture comprising a palladium (II) catalyst and a fluorinating reagent to form at least one of the ortho-fluorinated compounds having the formulae with good yield and selectivity.
    Type: Application
    Filed: July 11, 2012
    Publication date: January 16, 2014
    Applicant: The Scripps Research Institute
    Inventor: JIN-QUAN YU
  • Publication number: 20130317247
    Abstract: The invention provides a method for producing an aromatic amide carboxylic acid derivative represented by the following Formula (2), including a step of reacting an aromatic amide halide derivative represented by the following Formula (1) with carbon monoxide. In the following Formulae (1) and (2), R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; X1 represents a fluorine atom or a cyano group; X2 represents a halogen atom; and n represents an integer of from 0 to 3.
    Type: Application
    Filed: January 23, 2012
    Publication date: November 28, 2013
    Applicant: MITSUI CHEMICALS AGRO, INC.
    Inventors: Kazuki Kitajima, Kenji Kodaka, Hiroyuki Katsuta, Kunio Okumura
  • Patent number: 8586775
    Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: November 19, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
  • Publication number: 20130281444
    Abstract: The present invention provides a biphenyl benzamide-derived derivatives, which structure is selected from formula I or formula II: and the synthesis and the application thereof.
    Type: Application
    Filed: August 9, 2012
    Publication date: October 24, 2013
    Inventors: Deh-Ming CHANG, Hsu-Shan HUNAG, Chia-Chung LEE, Chun-Liang CHEN
  • Publication number: 20130225810
    Abstract: Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description.
    Type: Application
    Filed: November 3, 2011
    Publication date: August 29, 2013
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Hua Bai, Xuyang Zhao, Yongxiang Gong, Jinqing Zhong, Qifeng Zhu, Xiaoyu Liu, Lifei Liu, Qixian Zhou
  • Publication number: 20130184343
    Abstract: A compound of formula (I): wherein A1, A2, A3, A4, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts or N-oxides thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control insect, acarine, mollusc and nematode pests.
    Type: Application
    Filed: March 4, 2013
    Publication date: July 18, 2013
    Applicants: Syngenta Crop Protection LLC, Syngenta Participations AG
    Inventor: Syngenta Participations AG
  • Patent number: 8449794
    Abstract: A non-resonant two-photon absorption recording material containing at least (a) a non-resonant two-photon absorption compound, and (b) a recording component in which at least either a refractive index or fluorescence intensity changes, wherein the non-resonant two-photon absorption compound (a) is a compound having a structure represented by formula (1) as described.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: May 28, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Eri Takahashi, Masaharu Akiba, Hiroaki Tsuyama, Hidehiro Mochizuki
  • Publication number: 20130131371
    Abstract: There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (3): wherein R1, R2 and R3 independently represent a C1-C6 alkyl group optionally substituted with at least one halogen atom etc., R4, R5, R6 and R7 independently represent a halogen atom etc.
    Type: Application
    Filed: January 18, 2013
    Publication date: May 23, 2013
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Sumitomo Chemical Company, Limited
  • Patent number: 8431514
    Abstract: The present invention relates to bis-amide derivatives of formula (I), to processes and intermediates for preparing them, to methods of using them to control insect, acarine, nematode and mollusc pests, and to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising them.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: April 30, 2013
    Assignee: Syngenta Crop Protection LLC
    Inventors: Pierre Joseph Marcel Jung, Christopher Richard Ayles Godfrey, Ottmar Franz Hueter, Peter Maienfisch
  • Patent number: 8389766
    Abstract: A compound of formula (I): wherein A1, A2, A3, A4, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: March 5, 2013
    Assignee: Syngenta Crop Protection LLC
    Inventors: Pierre Jung, Christopher Richard Syles Godfrey, William Lutz, Peter Maienfisch, Andre Stoller, Werner Zambach
  • Publication number: 20120319059
    Abstract: A non-resonant two-photon absorption recording material containing at least (a) a non-resonant two-photon absorption compound, and (b) a recording component in which at least either a refractive index or fluorescence intensity changes, wherein the non-resonant two-photon absorption compound (a) is a compound having a structure represented by formula (1) as described.
    Type: Application
    Filed: February 18, 2011
    Publication date: December 20, 2012
    Applicant: FUJIFILM CORPORATION
    Inventors: Eri Takahashi, Masaharu Akiba, Hiroaki Tsuyama, Hidehiro Mochizuki
  • Publication number: 20120309812
    Abstract: The present invention relates to certain bisamide derivatives of formula (I), to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests compounds.
    Type: Application
    Filed: February 1, 2011
    Publication date: December 6, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Pierre Joseph Marcel Jung, Christopher Richard Ayles Godfrey, Ottmar Franz Hueter, Peter Renold
  • Publication number: 20120295907
    Abstract: The present invention relates to bis-amide derivatives of formula (I), to processes and intermediates for preparing them, to methods of using them to control insect, acarine, nematode and mollusc pests, and to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising them.
    Type: Application
    Filed: April 14, 2010
    Publication date: November 22, 2012
    Applicant: SYNGENTA CROP PROTECTION, LLC
    Inventors: Peter Maienfisch, Christopher Richard Ayles Godfrey, Pierre Joseph Marcel Jung, Ottmar Franz Hueter, Peter Renold
  • Patent number: 8314146
    Abstract: The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia): wherein, R3, R4, R5, R6, R7, P, Q, T, V, W, X, Y, Z, a, m and n are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: November 20, 2012
    Assignee: Merial Limited
    Inventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Philip Reid Timmons
  • Publication number: 20120277185
    Abstract: To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent: wherein each substituent is as defined in the specification.
    Type: Application
    Filed: July 10, 2010
    Publication date: November 1, 2012
    Applicant: BAYER CROPSCIENDE AG
    Inventors: Jun Mihara, Koichi Araki, Takuma Mori, Tetsuya Murata, Yasushi Yoneta, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Görgens
  • Publication number: 20120237446
    Abstract: The present invention relates to novel compounds (3-aminopropen-1-ones) useful for binding and imaging beta amyloid deposits and their use in detecting or treating Alzheimer's disease and amyloidosis.
    Type: Application
    Filed: March 26, 2012
    Publication date: September 20, 2012
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Ulrike Röhn, Hermann Künzer, Tobias Heinrich, Markus Berger, Damian Brockschnieder, Sabine Krause, Thomas Dyrks, Andrea Thiele, Ursula Mönning, Ulf Bömer
  • Publication number: 20120232138
    Abstract: Novel amidoacetonitrile compounds and compositions containing the compounds are disclosed. The compounds have pesticidal properties and are suitable for controlling endoparasites on warm-blooded animals.
    Type: Application
    Filed: November 22, 2010
    Publication date: September 13, 2012
    Applicant: Novartis AG
    Inventors: Thomas Goebel, Noëlle Gauvry, Heinz Sager
  • Publication number: 20120202854
    Abstract: Compounds of formula (I): in which R1, R2, R7, R8, R9, R10 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.
    Type: Application
    Filed: April 17, 2012
    Publication date: August 9, 2012
    Applicant: ARRAY BIOPHARMA INC.
    Inventors: George Doherty, Adam Cook
  • Publication number: 20120122975
    Abstract: The present invention relates to bis-amide derivatives of formula (I), to processes and intermediates for preparing them, to methods of using them to control insect, acarine, nematode and mollusc pests, and to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising them.
    Type: Application
    Filed: April 14, 2010
    Publication date: May 17, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Pierre Joseph Marcel Jung, Christopher Richard Ayles Godfrey, Ottmar Franz Hueter, Peter Maienfisch
  • Publication number: 20120107416
    Abstract: The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi.
    Type: Application
    Filed: January 14, 2010
    Publication date: May 3, 2012
    Applicant: DOW AGROSCIENCES LLC
    Inventors: David H. Young, Steven Howard Shaber, Gerald Shaber, Cruz Avila-Adame, Nneka T. Breaux, James M. Ruiz, Thomas L. Siddall, Jeffery D. Webster
  • Publication number: 20120065204
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The present invention is also directed to processes for making said compounds and uses of said compounds, in particular their use as medicaments, more particularly their use as medicaments in the treatment of cancer.
    Type: Application
    Filed: September 7, 2011
    Publication date: March 15, 2012
    Inventors: Lei Guo, Guozhi Tang, Zhanguo Wang, Jason Christopher Wong, Weixing Zhang
  • Publication number: 20120022257
    Abstract: Disclosed is a method for preparing HIV reverse transcriptase inhibitors which inhibit replication of HIV in HIV infected cells, and novel intermediate compounds used therein.
    Type: Application
    Filed: January 26, 2010
    Publication date: January 26, 2012
    Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Stacey Heumann, Christopher M. Levins, Steven Pfeiffer, Donald Tang
  • Publication number: 20120021065
    Abstract: The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi.
    Type: Application
    Filed: January 14, 2010
    Publication date: January 26, 2012
    Applicant: Dow Agrosciences LLC
    Inventors: David H. Young, Steven Howard Shaber, Cruz Avila-Adame, Nneka T. Breaux, James M. Ruiz, Thomas L. Siddall, Jeffery D. Webster
  • Publication number: 20110312911
    Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: February 3, 2010
    Publication date: December 22, 2011
    Inventors: Roman Kats-Kagan, Christian P. Stevenson, Xibin Liao, Qinghong Fu, Emma R. Parmee, Songnian Lin
  • Publication number: 20110306621
    Abstract: An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT5A receptor modulating action. It was confirmed that acylguanidine derivatives, which has the characteristic structure in which the guanidine is bonded to one ring of a naphthalene via a carbonyl group and a cyclic group is bonded to the other ring thereof, exhibit potent 5-HT5A receptor modulating action and excellent pharmacological action based on the action. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder or attention deficit hyperactivity disorder.
    Type: Application
    Filed: February 8, 2010
    Publication date: December 15, 2011
    Inventors: Isao Kinoyama, Takehiro Miyazaki, Yohei Koganemaru, Nobuyuki Shiraishi, Yuichiro Kawamoto, Takuya Washio
  • Patent number: 8067640
    Abstract: The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: November 29, 2011
    Assignee: H. Lundbeck A/S
    Inventors: Naoki Taoka, Takahisa Kato, Shogo Yamamoto, Takashi Yoshida, Toshihiro Takeda, Yasuyoshi Ueda, Hans Petersen, Robert Dancer, Haleh Ahmadian, Lars O. Lyngso
  • Publication number: 20110251248
    Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: December 9, 2009
    Publication date: October 13, 2011
    Inventors: Songnian Lin, Xibin Liao, Roman Kats-Kagan, John E. Stelmach, Emma R. Parmee
  • Patent number: 8034955
    Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: October 11, 2011
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
  • Patent number: 8034968
    Abstract: Disclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula 4 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; and X is Br, Cl or I.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: October 11, 2011
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Gary David Annis
  • Publication number: 20110230465
    Abstract: Compounds of formula I: wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
    Type: Application
    Filed: September 16, 2010
    Publication date: September 22, 2011
    Applicant: BOEHRINGER INGLEHEIM INTERNATIONAL GMBH
    Inventors: Timothy STAMMERS, Xavier BARBEAU, Pierre BEAULIEU, Megan BERTRAND-LAPERLE, Christian BROCHU, Paul J. EDWARDS, Pasquale FORGIONE, Cédrickx GODBOUT, Oliver HUCKE, Marc-André JOLY, Serge LANDRY, Olivier LEPAGE, Julie NAUD, Marc PESANT, Martin POIRIER, Maude POIRIER, Bounkham THAVONEKHAM
  • Publication number: 20110190231
    Abstract: The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia): wherein, R3, R4, R5, R6, R7, P, Q, T, V, W, X, Y, Z, a, m and n are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.
    Type: Application
    Filed: April 13, 2011
    Publication date: August 4, 2011
    Inventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Philip Reid Timmons
  • Publication number: 20110009457
    Abstract: The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.
    Type: Application
    Filed: December 9, 2008
    Publication date: January 13, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Ulrich Görgens, Katsuaki Wada, Yukiyoshi Watanabe, Jun Mihara, Koichi Araki
  • Patent number: RE44339
    Abstract: Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4 straight or branched alkoxy, X is (CH2)n—R, where n is 0 or 1 and R is a group with non-bonding electrons, with the provisos that: (a) when Y and Z are H, X is not F, OH, MeO or NO2 in the 4-position and is not OH in the 2 or 6-position (b) when Y or Z is H then X, Y and Z are such that (i) the groups in the 3- and 4-positions are not both OMe, (ii) the groups in the 4- and 5-positions are not both OMe, (iii) the groups in 3- and 5-positions are not OMe if the group in the 4-position is OH, and (iv) the groups in the 3- and 5-positions are not OH if the group in the 4-position is methyl.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: July 2, 2013
    Assignee: Givaudan S.A.
    Inventors: Christophe C. Galopin, Pablo Victor Krawec, Jay Patrick Slack, Lori W. Tigani