Plural Cyano Groups Containing Patents (Class 558/419)
  • Patent number: 10988576
    Abstract: The compound of the present application has a low melting point and excellent flexibility, and the like, so that a phthalonitrile resin, a prepolymer thereof, or a polymerizable composition forming the same can exhibit excellent workability and a wide process window and it can be made to ensure improved impact strength. The compound can form the phthalonitrile resin or the like into a liquid phase or form it into a rubber phase. Such a phthalonitrile resin or the like can be applied to various applications.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: April 27, 2021
    Assignee: LG CHEM, LTD.
    Inventors: Seung Hee Lee, Sang Woo Kim, Ki Ho Ahn, Yulliana Kim
  • Publication number: 20140248236
    Abstract: The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
    Type: Application
    Filed: November 7, 2012
    Publication date: September 4, 2014
    Inventors: Michael G. Natchus, Richard Arrendale
  • Publication number: 20140213598
    Abstract: Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agriculture and effectively prevents against a variety of pathogens such as cucumber downy mildew, wheat powdery mildew, maize rust disease, rice blast and cucumber gray mold. In particular, even at a low dose, the compound effectively prevents and treats rice blast, cucumber gray mold, maize rust disease and cucumber downy mildew. Moreover, the raw materials for preparing the compounds are widely available and the synthesis method therefor is simple and convenient.
    Type: Application
    Filed: June 15, 2012
    Publication date: July 31, 2014
    Applicants: SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD., SINOCHEM CORPORATION
    Inventors: Changling Liu, Guang Huang, Jie Lan, Shulin Hao, Zhinian Li, Huichao Li, Aiying Guan, Airu Jiang, Ying Xu
  • Publication number: 20140138632
    Abstract: An amine-based compound and an organic light-emitting diode including the amine-based compound are provided. The amine-based compound may be used between a pair of electrodes of an organic light-emitting diode. For example, the amine-based compound may be used in an emission layer and/or between the emission layer and an anode (for example, in a hole injection layer, a hole transport layer, a functional layer having a hole injection ability and a hole transport ability). Accordingly, an organic light-emitting diode including a first electrode, a second electrode facing the first electrode, and an organic layer that is interposed between the first electrode and the second electrode, and includes the amine-based compound is provided.
    Type: Application
    Filed: March 13, 2013
    Publication date: May 22, 2014
    Inventors: Young-Kook Kim, Seok-Hwan Hwang, Hye-Jin Jung, Jun-Ha Park, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jong-Hyuk Lee
  • Publication number: 20130228752
    Abstract: A pyrene-based compound, an organic light-emitting diode including the compound and an organic light-emitting apparatus including the compound are disclosed.
    Type: Application
    Filed: June 29, 2012
    Publication date: September 5, 2013
    Inventors: Dong-Woo Shin, O-Hyun Kwon, Kyul Han, Seul-Ong Kim, Byoung-Ki Choi
  • Publication number: 20130221331
    Abstract: A compound is shown by the following formula (1). wherein l, m, and n are independently an integer from 1 to 3, Ar1 to Ar4 are independently a substituted or unsubstituted aryl group having 6 to 30 ring carbon atoms, or a substituted or unsubstituted heteroaryl group having 5 to 30 ring atoms, Ar5, Ar6, and Ar7 are independently a substituted or unsubstituted arylene group having 6 to 30 ring carbon atoms, or a substituted or unsubstituted heteroarylene group having 5 to 30 ring atoms, and p is an integer from 0 to 2, and Ar6 and N are bonded via a single bond when p is 0, provided that at least one of Ar1 to Ar4 is substituted with a substituted silyl group, a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, or a substituted or unsubstituted cycloalkyl group having 3 to 10 carbon atoms, and at least one of Ar1 to Ar4 is substituted with a cyano group.
    Type: Application
    Filed: October 24, 2011
    Publication date: August 29, 2013
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Yumiko Mizuki, Hiroyuki Saito, Yuichiro Kawamura, Hirokatsu Ito, Masahiro Kawamura
  • Publication number: 20130123287
    Abstract: Providing a novel control agent for soft rot and a novel control method for the same. A compound having no antibacterial activity against Erwinia carotovora but having a control activity against fungi on soil surface, specifically containing, as the active ingredient, a fungicide comprising any of a strobilurin compound such as azoxystrobin and kresoxim-methyl, an azole compound such as triflumizol, cyazofamid, amisulbrom, and thiophanate-methyl, a carboxamide compound such as penthiopyrad and boscalid, a sulfonamide compound such as flusulfamide, an organic chlorine compound such as chlorothalonil, a dicarboximide compound such as pro-cymidone and iprodione, a phenylpyrrole compound such as fludioxonil, an anilinopyrimidine compound such as mepanipyrim, and a guanidine compound such as iminoctadine is the control agent for plant soft rot, which is applied to plant cultivation soil.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 16, 2013
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventors: Koji Sugimoto, Hiroyuki Hayashi
  • Patent number: 8299247
    Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: October 30, 2012
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventor: Hironobu Morishita
  • Publication number: 20120187383
    Abstract: There is provided an a host material and a dopant material, wherein the host material is a compound having one of Formulae I-VI: In the formulae, R1 is the same or different at each occurrence and represents an optional substituent which may be present at any or all of the available sites and may be D, alkyl, aryl, alkoxy, aryloxy, oxyalkyl, alkenyl, silyl, or siloxane; Ar1, Ar2, and Ar3 are the same or different at each occurrence and are aryl groups; a is an integer from 2-6; and b is an integer from 1-3.
    Type: Application
    Filed: August 1, 2011
    Publication date: July 26, 2012
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: WEIYING GAO, Weishi Wu, Kalindi Dogra, Vsevolod Rostovtsev, Kerwin D. Dobbs
  • Publication number: 20120135823
    Abstract: An object of the present invention is to provide a golf ball having high resilience. The gist of the present invention resides in selecting an organic sulfur compound used for a golf ball rubber composition containing (a) a base rubber, (b) a co-crosslinking agent, (c) a crosslinking initiator, and (d) the organic sulfur compound from organic sulfur compounds having specific structures such that a sum of substituent constants of the substituents X in a structure represented by the following formula (4) is 0.2 or more and SP value of the structure represented by the following formula (4) is in a range from 19.0 (J/cm3) using the same.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 31, 2012
    Inventors: Ayaka HIBI, Chiemi Mikura, Kazuhisa Fushihara, Yumi Kanemitsu, Mikio Yamada
  • Publication number: 20110275814
    Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.
    Type: Application
    Filed: July 18, 2011
    Publication date: November 10, 2011
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventor: Hironobu MORISHITA
  • Publication number: 20110195979
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
    Type: Application
    Filed: February 7, 2011
    Publication date: August 11, 2011
    Inventors: Li Chen, Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Lisha Wang, Jim Zhen Wu, Wengang Yang
  • Patent number: 7723385
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: May 25, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, David John Cowan, Andrew Lamont Larkin, Istvan Kaldor, Eugene Lee Stewart
  • Publication number: 20090189086
    Abstract: Phthalocyanines of the formula (I) where the symbols and indices each have the definitions specified in the description are suitable as markers for liquids, especially mineral oils.
    Type: Application
    Filed: March 7, 2007
    Publication date: July 30, 2009
    Applicant: BASF SE
    Inventors: Thomas Gessner, Sophia Ebert, Rüdiger Sens, Martin Könemann, Wolfgang Ahlers, Christos Vamvakaris
  • Publication number: 20090170907
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: June 6, 2006
    Publication date: July 2, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Lamont Larkin, Eugene Lee Stewart, Katherine Stetson
  • Patent number: 7514470
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: April 7, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, David John Cowan, Andrew Lamont Larkin, Istvan Kaldor, Eugene Lee Stewart
  • Patent number: 7514563
    Abstract: A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: April 7, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventors: Milton R. Smith, III, Robert E. Maleczka, Ghayoor A. Chotana
  • Patent number: 7374822
    Abstract: A near-infrared ray shielding paint capable of forming a coating that exhibits high light transmission coefficient in visible light region while having high shielding capability in near-infrared region and exhibits little chromaticity change even in harsh environment, which near-infrared ray shielding paint comprises a first near-infrared ray-absorption coloring matter containing a compound composed of a diimonium compound cation and an anion of the formula (1), a second near-infrared ray-absorbing coloring matter of different type and a transparent resin in which a compound of the formula (2) is polymerized in an amount of 30% by mass or more. A near-infrared ray shielding laminate having a near-infrared ray shielding layer is produced with the use of this paint. (CF3SO2)2N? ??(1) [R is H or a —CH3 group, and X is a C6-C25 cyclohydrocarbon group].
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: May 20, 2008
    Assignee: Sumitomo Osaka Cement Co., Ltd.
    Inventors: Tetsuya Nakabeppu, Tsutomu Tamura
  • Patent number: 7311860
    Abstract: The present invention relates to 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives and method for preparing the same. The 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives can be prepared by refluxing 1,3,5-tricyanomesitylene with N-formylamine dimethylacetal or substituted benzaldehyde, or by the Wittig reaction of 1,3,5-tricyano-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene with substituted benzaldehyde. The 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives exhibit large first hyperpolarizability in solution and significant second harmonic generation (SHG) in the powder state, and are useful as optical devices such as electro-optic modulators, optical switch, or the like for treating optical signal in optical communication industry.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: December 25, 2007
    Assignee: Korea University Foundation
    Inventors: Bong-Rae Cho, Seung-Joon Jeon, Min-Haeng Cho
  • Patent number: 7161021
    Abstract: In a process for producing a polynitrile compound comprising introducing a polysubstituted organic compound (POC) which is a carbon ring or heterocyclic compounds having a plurality of organic substituents into a reactor with ammonia and a gas containing oxygen and ammoxidizing POC in the presence of a catalyst, at least a portion of the unreacted POC and a mononitrile compound of an intermediate product in the reaction gas discharged from the reactor is separated, recovered and recycled to the reactor so that the flow rate of the mononitrile compound at the outlet of the reactor is 2 to 16% by mole of the total flow rate of POC and the mononitrile compound supplied to the reactor. Burning reaction of the side reaction is suppressed and the loss of POC can be decreased without adverse effects on productivity and the polynitrile compound can be obtained at a high yield.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: January 9, 2007
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Kenichi Nakamura, Shuji Ebata, Fumio Tanaka, Takuji Shitara
  • Patent number: 7132561
    Abstract: An object of the invention is to provide a process for industrially producing fluorinated dicyanobenzenes using tetrachlorodicyanobenzene as a raw material. According to the present invention, fluorinated dicyanobenzene can be produced in a high yield by allowing tetrachlorodicyanobenzenes to react with a fluorinating agent in the presence of a non-protonic polar solvent in an amount of 0.1 to 3 times by mass based on the tetrachlorodicyanobenzene. Further, the above production can be conducted more efficiently by reacting while disintegrating or removing bulk solid matters.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: November 7, 2006
    Assignee: Showa Denko K.K.
    Inventors: Toru Sasaki, Tetsuhiro Furukawa, Yoshinori Sato, Takuji Yamamoto, Takashi Yoneyama
  • Patent number: 7022868
    Abstract: This invention is an aminostyrylanthracene compound represented by, for example, the following general formula [I]. This compound is produced by condensation from a corresponding aminobenzaldehyde and a phosphonic ester or phosphonium salt. [where, in the general formula [I] above, R2 represents an unsubstituted aryl group, R1 represents an aryl group which may have a variety of substituents, and R3 to R5 each represent a hydrogen atom, a cyano group, or a hydrocarbon group.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: April 4, 2006
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Patent number: 6933402
    Abstract: The present invention is phthalocyanine compounds with peripheral siloxane substitution, as well as methods for making these compounds and various uses thereof, having the basic structure: wherein —W—X—Y-Z are peripheral groups comprising individual W, X, Y, and Z subgroups; W is a linkage represented by the formula: -D-(R1)0,1—, where D=S or O; X is: —(CH2)n—, n=2 to 8; Y is a siloxane chain; Z is an aryl or alkyl terminal cap; M is two protons or a metal ion; and forms a transparent film of high optical quality with large nonlinear absorption and thermal refraction, free of scattering from solid or liquid crystalline domains making them highly suitable for use as the active component in thin films, protective eye wear, and optical data storage applications.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: August 23, 2005
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Arthur W. Snow, James S Shirk, Eva M Maya, Richard G. S. Pong, Steven R. Flom
  • Patent number: 6906217
    Abstract: This invention is an aminostyrylanthracene compound represented by, for example, the following general formula [I]. This compound is produced by condensation from a responding aminobenzaldehyde and a phosphonic ester or phosphonium salt. [where, in the general formula [I] above, R2 represents an unsubstituted aryl group, R1 represents a group which may have a variety of substituents, and R3 to R5 each represent a hydrogen atom, a cyano group, or a hydrocarbon group.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 14, 2005
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Publication number: 20040251452
    Abstract: The present invention relates to 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives and method for preparing the same. The 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives can be prepared by refluxing 1,3,5-tricyanomesitylene with N-formylamine dimethylacetal or substituted benzaldehyde, or by the Wittig reaction of 1,3,5-tricyano-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene with substituted benzaldehyde. The 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives exhibit large first hyperpolarizability in solution and significant second harmonic generation (SHG) in the powder state, and are useful as optical devices such as electro-optic modulators, optical switch, or the like for treating optical signal in optical communication industry.
    Type: Application
    Filed: January 26, 2004
    Publication date: December 16, 2004
    Inventors: Bong-Rae Cho, Seung-Joon Jeon, Min-Haeng Cho
  • Patent number: 6821963
    Abstract: Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: November 23, 2004
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Haile Tecle
  • Patent number: 6790975
    Abstract: This invention is an aminostyrylanthracene compound represented by, for example, the following general formula [I]. This compound is produced by condensation from a corresponding aminobenzaldehyde and a phosphonic ester or phosphonium salt. [where, in the general formula [I] above, R2 represents an unsubstituted aryl group, R1 represents an aryl group which may have a variety of substituents, and R3 to R5 each represent a hydrogen atom, a cyano group, or a hydrocarbon group.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: September 14, 2004
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Publication number: 20040175638
    Abstract: The invention relates to polymerisable charge transport compounds, their use as semiconductors or charge transport materials, in optical, electrooptical or electronic devices like for example organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in plotovoltaic and sensor devices, and to a field effect transistor, light emitting device or ID tag comprising the polymerisable charge transport compounds.
    Type: Application
    Filed: January 6, 2004
    Publication date: September 9, 2004
    Inventors: Steven Tierney, Mark Goulding, Louise Farrand, Mark Giles, Marcus Thompson, Maxim Shkunov, David Sparrowe, Iain McCulloch, Martin Heeney
  • Publication number: 20040065870
    Abstract: Organic dye molecular materials prepared by coupling existing organic chromophore molecules to benzene or carbazole derivatives and nonlinear optical polymer compounds having polyimide repeating units coupled with the organic dye molecular material are provided.
    Type: Application
    Filed: October 3, 2003
    Publication date: April 8, 2004
    Inventors: Jung Yun Do, Myung Hyun Lee, Seung Koo Park, Jung Jin Ju, Suntak Park
  • Publication number: 20040030173
    Abstract: An object of the invention is to provide a process for industrially producing fluorinated dicyanobenzenes using tetrachlorodicyanobenzene as a raw material.
    Type: Application
    Filed: April 4, 2003
    Publication date: February 12, 2004
    Inventors: Toru Sasaki, Tetsuhira Furukawa, Yoshinori Sato, Takuji Yamamoto, Takashi Yoneyama
  • Patent number: 6673956
    Abstract: The present invention relates to processes for the preparation of a compound of the formula wherein W is nitrogen or —CR3; R1 is halogen, haloalkyl, haloalkoxy, R4S(O)n— or —SF5; R2 is hydrogen; R3 is halogen; R4 is alkyl or haloalkyl; and n is 0, 1 or 2.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: January 6, 2004
    Assignee: Aventis Agriculture Ltd.
    Inventor: Jean-Erick Ancel
  • Publication number: 20030229242
    Abstract: This invention is an aminostyrylanthracene compound represented by, for example, the following general formula [I]. This compound is produced by condensation from a corresponding aminobenzaldehyde and a phosphonic ester or phosphonium salt.
    Type: Application
    Filed: May 8, 2003
    Publication date: December 11, 2003
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Publication number: 20030208089
    Abstract: This invention is an aminostyrylanthracene compound represented by, for example, the following general formula [I]. This compound is produced by condensation from a corresponding aminobenzaldehyde and a phosphonic ester or phosphonium salt.
    Type: Application
    Filed: May 8, 2003
    Publication date: November 6, 2003
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Patent number: 6630607
    Abstract: Aromatic methylidene compounds of the following general formula wherein R11 and R21 independently in each occurrence represent an unsubstituted or substituted alkyl or alkoxy group, a halogen, a cyano group or a nitro group, n11 and n21 are, respectively, an integer, R31 and R41 independently represent hydrogen, an unsubstituted or substituted alkyl group, an unsubstituted or substituted cycloalkyl group, an unsubstituted or substituted aromatic group, or an unsubstituted or substituted aromatic heterocyclic group and may join to complete a condensed ring, along with other types of aromatic methylidene compounds wherein the moieties attached to the naphthalene ring are attached to different positions of the ring. The preparation of the methylidene compounds is also described along with intermediate compounds and their preparation.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: October 7, 2003
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventor: Mitsuru Hashimoto
  • Publication number: 20030149290
    Abstract: This invention is an aminostyrylanthracene compound represented by, for example, the following general formula [I]. This compound is produced by condensation from a corresponding aminobenzaldehyde and a phosphonic ester or phosphonium salt.
    Type: Application
    Filed: March 19, 2002
    Publication date: August 7, 2003
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Publication number: 20030146420
    Abstract: Organic dye molecular materials prepared by coupling existing organic chromophore molecules to benzene or carbazole derivatives and nonlinear optical polymeric compounds having polyimide repeating units coupled with the organic dye molecular material are provided.
    Type: Application
    Filed: February 27, 2002
    Publication date: August 7, 2003
    Inventors: Jung Yun Do, Myung Hyun Lee, Seung Koo Park, Jung Jin Ju, Suntak Park
  • Publication number: 20030087956
    Abstract: 1 A compound of formula (I) where D is a VLA-4 specificity determinant which does not impart significant IIB/IIIa activity; R41 is a group of the formula (V): U - (CH2)d - V - T wherein U is selected from oxygen, sulphur, a direct bond or —CH2O—, V is selected from nitrogen, oxygen, sulphur, S(O), S(O)2 or a direct bond, d is zero or a number from 1 to 4, and T is selected from a range of variables defined in the application; and other variables are defined in the application, or a pharmaceutically acceptable salt or in vivo hydrolysable derivative thereof. The compounds are useful in the treatment of disease mediated by the interaction between VCAM-1 and/or fibronectin and the integrin receptor &agr;4&bgr;1. Pharmaceutical compositions and methods of use or treatment are also described and claimed.
    Type: Application
    Filed: June 14, 2002
    Publication date: May 8, 2003
    Inventors: Craig Johnstone, Michael Stewart Large
  • Patent number: 6525092
    Abstract: Bis-oxime compounds of the general formula (I) are provided wherein X, Y, R1, R2 R3 and n are as defined in the specification. The bis-oxime compounds possess pesticidal activity, which may provide plants with protection from phytopathogenic microorganisms.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: February 25, 2003
    Assignee: Bayer Aktiengsellschaft
    Inventors: Hugo Ziegler, Stephan Trah
  • Patent number: 6525212
    Abstract: A bis(aminostyryl)benzene compound of the following general formula [I] is provided wherein R2 and R3 independently represent an unsubstituted aryl group, and R1 and R4 independently represent an aryl group, and R5 to R8 independently represent a cyano group or the like. A process for the preparation thereof is described wherein a 4-(N,N-diarylamino)benzaldehyde and a diphosphonic acid ester or diphosphonium salt are, for example, subjected to condensation reaction. Intermediates of the bis(aminostyryl)benzene compound are also described.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: February 25, 2003
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Shinichiro Tamura, Tadashi Ishibashi, Ichinori Takada
  • Patent number: 6475590
    Abstract: The present invention relates to an aminium salt or diimonium salt compound that is appropriate for use, for examples, in an optical recording medium to get the good characteristics in regeneration and storage stability as well as an infrared ray screening filter to get the excellent light fastness and heat fastness; and the use thereof. The aminium salt or diimonium salt compound comprises an aminium cation represented by the formula (1) as described below or a diimonium cation represented by the formula (2) as described below: (In the formula, m is an integer of 1 or 2; the two nitrogen atoms (quaternary nitrogen atoms in Formula (2)) bound to the ring A in Formula (1) or Formula (2) bind to the four B phenyl groups to whose 4-positions the optionally substituted four amino groups are substituted; and at least one of said four amino groups has a cyanoalkyl group as the substituent) with an anion.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: November 5, 2002
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Yasuyuki Kitayama, Masaaki Ikeda, Masao Ohnishi
  • Publication number: 20020161034
    Abstract: The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) 1
    Type: Application
    Filed: January 28, 2002
    Publication date: October 31, 2002
    Inventors: Hermann Hagemann, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Peter Dahmen, Markus Dollinger, Alan Graff, Wolfram Andersch
  • Patent number: 6472427
    Abstract: The (R)-enantiomer of 4-[[(cyanoimino)[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: October 29, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventor: Karnail S. Atwal
  • Patent number: 6458835
    Abstract: A method for inhibiting hair loss and/or promoting hair growth in chemotherapy and/or radiation therapy patients wherein the (R)-enantiomer of 4-[[(cyanoimino)-[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile is administered prior to, simultaneous with and/or after chemotherapy and/or radiation treatment.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: October 1, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventor: Karnail S. Atwal
  • Patent number: 6437167
    Abstract: The present invention describes new chiral stationary phases and optically active compounds therein contained. The optically active compounds contained in the stationary phases are represented by the formula of structure (I), containing at least one asymmetric carbon atom, and a substituent acting as a spacer. The stationary phases of the present invention are useful in the preparation of chromatographic columns useful for the separation of enantiomers.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: August 20, 2002
    Assignee: Societa' Cooperative Centro Ricerche Polytech A Responsabilitia' Limitata
    Inventors: Vitomir Sunjic, Darko Kontrec, Vladimir Vinkovic
  • Patent number: 6420130
    Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: July 16, 2002
    Assignee: Aurora Biosciences Corporation
    Inventors: Lewis R. Makings, Gregor Zlokarnik
  • Patent number: 6337167
    Abstract: To provide compounds, which are suitable for use as an organic luminescent material capable of developing intense luminescence which is yellow to red, and a process for preparing in general and high efficiency. A bis(aminostyryl)benzene compound of the following general formula [I] is provided wherein R2 and R3 independently represent an unsubstituted aryl group, and R1 and R4 independently represent an aryl group, and R5 to R8, independently represent a cyano group or the like. A process for the preparation thereof is described wherein a 4-(N,N-diarylamino)benzaldehyde and a diphosphonic acid ester or diphosphonium are subjected to condensation reaction. Intermediates of the bis(aminostyryl)benzene compound are also described.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: January 8, 2002
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Shinichiro Tamura, Tadashi Ishibashi, Ichinori Takada
  • Patent number: 6316629
    Abstract: There is provided a process for the preparation of 2,3-pyridinedicarboximides having the structural formula I The 2,3-pyridinedicarboximides are useful as intermediates in the preparation of herbicidal 2-(2-imidazolin-2-yl)nicotinic acids, esters and salts.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: November 13, 2001
    Assignee: American Cyanamid Co.
    Inventors: Kenneth Alfred Martin Kremer, Wen-Xue Wu, Donald Roy Maulding
  • Patent number: 6268504
    Abstract: The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, —NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, —CN, —O—R1, —O—Ar, —S—R1, —S—Ar, —SO—R1, —SO—Ar, —SO2—R1, —SO2—Ar, —CO—R1, —CO—Ar, —CO2—R1, or —CO2—Ar; and Y is selected from a) the moiety: wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 31, 2001
    Assignee: American Home Products Corporation
    Inventors: Panolil Raveendranath, Joseph Zeldis, Galina Vid, John R. Potoski, Jianxin Ren, Silvio Iera
  • Patent number: 6242605
    Abstract: The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is 0 or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, —NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, —CN, —O—R1, —O—Ar, —S—R1, —S—Ar, —SO—R1, —SO—Ar, —SO2—R1, —SO2—Ar, —CO—R1, —CO—Ar, —CO2—R1, or —CO2—Ar; and Y is selected from a) the moiety: wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: June 5, 2001
    Assignee: American Home Products Corporation
    Inventors: Panolil Raveendranath, Joseph Zeldis, Galina Vid, John R. Potoski, Jianxin Ren, Silvio Iera
  • Patent number: 6127568
    Abstract: Phenylacetic acid derivatives of the formula I ##STR1## where the substituents and the index have the following meanings: X is NOCH.sub.3, CHOCH.sub.3, CHCH.sub.3 and [sic] CHCH.sub.2 CH.sub.3 ;R.sup.1 is hydrogen and [sic] alkyl;R.sup.2 is cyano, nitro, trifluoromethyl, halogen, alkyl and [sic] alkoxy;m is 0, 1 or 2, it being possible for the R.sup.2 radicals to be different if m is 2;R.sup.3 is hydrogen, cyano, nitro, hydroxyl, amino, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylamino or dialkylamino;R.sup.4 and R.sup.5 are as defined in the specification.
    Type: Grant
    Filed: August 18, 1998
    Date of Patent: October 3, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Herbert Bayer, Hubert Sauter, Ruth Muller, Wassilios Grammenos, Albrecht Harreus, Reinhard Kirstgen, Franz Rohl, Eberhard Ammermann, Gisela Lorenz