Abstract: The present invention relates to novel derivatives of oxazaphosphorines, pharmaceutical compositions and therapeutic uses thereof, in particular for treating or preventing cancer.

Abstract: A method for improving wear control in an engine or other mechanical component lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition that includes a lubricating oil base stock as a major component; and at least one phosphazene represented by the formula as a minor component. In the above formula, Q is nitrogen, sulfur or oxygen; a is a value from about 2 to about 6, c is a value from about 2 to about 6, e is a value from about 2 to about 6, g is a value from about 2 to about 6, i is a value from about 2 to about 6, and k is a value from about 2 to about 6; b is a value of 2a+q, d is a value of 2c+r, f is a value of 2e+s, h is a value of 2g+t, j is a value of 2i+u, and l is a value of 2k+v; q, r, s, t, u and v are independently a value of 0 or ?2; with the proviso that not all of a, c, e, g, i and k are the same value.

Abstract: Provided are novel dihydro-1H-phosphole 1-oxide derivatives and a preparation method thereof. More particularly, the dihydro-1H-phosphole 1-oxide derivatives include 1,3-dihydro-1H-2,1-oxaphosphole 1-oxide derivatives and 2,3-dihydro-1H-2,1-azaphosphole 1-oxide derivatives. Further, in the preparation method of a dihydro-1H-phosphole 1-oxide derivative according to the present invention, various phosphinine oxide derivatives may be prepared with high yield by a simple synthesis process by reacting a phosphinic derivative and a vinyl derivative with each other in the presence of a rhodium (Rh) catalyst, an oxidant, and a base.

Abstract: Compositions for use in lubricating thin film storage media are provided, as well as storage media formed using the compositions, the compositions including one or more central cores having a cyclic group, and a plurality of arms extending from the central cores, wherein each arm comprises phenol or piperonyl. Methods of preparing the compositions are also provided. Methods of preparing storage media that incorporate the compositions therein are further provided.

Abstract: A method of treating an aqueous liquid. The method comprises providing an aqueous feed liquid comprising water and at least one solute to a first side of a membrane. A draw solution comprising water and a draw solute comprising at least one of a phosphazene compound and a triazine compound is provided to a second side of the membrane. At least a portion of the water of the aqueous feed liquid is osmosed across the membrane and into the draw solution to form a diluted draw solution comprising water and the draw solute. The water of the diluted draw solution is separated from the draw solute of the diluted draw solution to form a purified water product. Draw solutes comprising phosphazene compounds and draw solutes comprising triazine compounds are also disclosed, as are methods of forming the draw solutes.

Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

Abstract: The present invention relates to the use of dendrimers with monophosphonic or bisphosphonic terminations in order to stimulate the growth of cell cultures or to activate cells in culture.

Abstract: A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.

Abstract: A phosphazene compound of the formula (1) or (5) which has an arrangement such that perfluoroxyalkylene units selected from —CF2O— and —CF2CF2O— are randomly distributed, the compound having a functional terminal group A or group G A—OCH2CF2O(CF2CF2O)p(CF2O)qCF2CH2O—A  (1) G—[OCH2CF2O(CF2CF2O)p(CF2O)qCF2CH2OH]6-z  (5) wherein A is a group of the formula (a) and G is a group of the formula (g) shown in the specification, and a lubricant containing at least one of the phosphazene compounds of the formulas (1) and (5).

Abstract: This invention provides a halogen-free flame retardant which advantageously has a high melting point and a low volatility and does not impair the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as a phenylene group, wherein each of the crosslinking groups is interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound; the crosslinked phenoxyphosphazene compound does not have any free hydroxyl groups (derived from crosslinking groups); and the amount of the phenyl groups in the crosslinked compound is 50 to 99.9%, based on the total number of the phenyl groups in the phosphazene compound.

Abstract: A phosphazene compound of the formula (1) or (5) which has an arrangement such that perfluoroxyalkylene units selected from —CF2O— and —CF2CF2O— are randomly distributed, the compound having a functional terminal group A or group G

Abstract: This invention relates to novel benzo-2-triazole substituted compounds, pharmaceutical compositions, processes for their preparation, and use thereof in treating IL-8, GRO&agr;, GRO&bgr;, GRO&ggr; and NAP-2 mediated diseases.

Abstract: The present invention provides a process for preparing a mixture of amino-containing phosphazenes having the following general formula (I) by reacting a (NPCl2)n phosphazene mixture with NH3 and HOR in the presence of a tertiary amine catalyst: NnPn(NH2)x(OR)2n−x  (l) wherein n≧3, 1≦x<2n, and R is phenyl or C3-C6 alkyl. In addition to simultaneously carrying out amination and esterification, the process of the present invention also simultaneously performs a regeneration of the catalyst. Furthermore, the invented process is a water-free process without the problem of a large quantity of waste water. Ammonium chloride, a by-product of the invented process, can be recovered in a subsequent process.

Abstract: Incorporation of phosphate and phosphonate units into the side groups of aryloxyphosphazenes, at both the polymer and cyclic trimer levels, is disclosed. Phosphorylated cyclic trimers are utilized as flame-retardant additives to polystyrene.

Abstract: New phosphazene derivatives, fully substituted by aromatic groups and perfluoropolyethereal chains, are utilized as stabilizers for oils and greases based on perfluoropolyethers. Such derivatives inhibit the degradation process affecting the perfluoropolyethereal chains when these are subjected to high temperatures in an oxidizing atmosphere and in the presence of metals, such as for example aluminium, titanium, vanadium and their alloys, or steels.

Abstract: New phosphazene derivatives, fully substituted by aromatic groups and perfluoropolyethereal chains, are utilized as stabilizers for oils and greases based on perfluoropoyethers. Such derivatives inhibit the degradation process affecting the perfluoropolyethereal chains when these are subjected to high temperatures in an oxidizing atmosphere and in the presence of metals, such as for example aluminium, titanium, vanadium and their alloys, or steels.

Abstract: Substituted 1,3,2,4-diazadiphosphetidines of formula I ##STR1## where preferably, R.sub.1 and R.sub.2 are branched alkyl or aryl, m and n are 1, p and q are 0, and YR.sub.3 and XR.sub.4 are substituted --O--phenyl or --N(alkyl).sub.2, are excellent stabilizers for organic materials, particularly polyolefins.

Abstract: The oxidation resistance of a cyclophosphazene-based fluid (such as a lubricant or a hydraulic fluid) can be improved by the addition to the fluid of an oxidation-inhibiting amount of an aryl phosphine or phosphine oxide. The aryl phosphine or phosphine oxide is preferably present in an amount of about 0.01 to about 5 percent by weight. The aryl phosphine or phosphine oxide can be (a) a symmetric triarylphosphine of formula R.sub.3 P, wherein R is 4-trifluoromethyl phenyl, 3-trifluoromethyl phenyl, 3-trifluoromethoxy phenyl, 3-(3-trifluoromethylphenoxy) phenyl, 3-(perfluoro-2, 5-dimethyl-3, 6-dioxanonyl) phenyl or 1-naphthyl; (b) an oxide of any of these symmetric triarylphosphines; or (c) 1, 3-bis(diphenylphosphino) benzene.

Abstract: The object of the present invention is to provide a lubricant which has a wide range viscosity-temperature characteristic, low pour point and compatibility with hydrogen-containing chloro-fluoro carbons and fluoro carbons refrigerants.To achieve the object mentioned above, a lubricant for hydrogen-containing chloro-fluoro carbon and fluoro carbon refrigerants according to the present invention has a formula (1): ##STR1## wherein n is 3 to 4, X and X' are same or different and each selected from a group of moieties represented by the formula:R.sub.1 --(OR.sub.2).sub.l --O--wherein R.sub.1 is an alkyl group of 1 to 12 carbon atoms or aryl group of 6 to 18 carbon atoms, R.sub.2 is an alkylene group of 2 to 4 carbon atoms, and the chain of OR.sub.

Abstract: The present invention provides an antistatic composition comprising a binder, a cyclic phosphazene, and a salt that complexes with the cyclic phosphazene. The cyclic phosphazene has the general formula ##STR1## wherein x is 3 or 4.

Abstract: Amphiphilic compound having one of the following structures:(X--T).sub.n --A--Y.sub.m and (X-T).sub.n --R--(T--A).sub.nwherein X is a fluorocarbon terminal group, T is a polar linking group, A is a nucleus other than saturated lower aliphatic, Y is a polar nonlinking group, R is a saturated or unsaturated, substituted or unsubstituted, straight or branched lower aliphatic group, n is at least one, and the sum of n and m is at least two. Such compounds are useful as lubricants for magnetic media. Also, a lubricated magnetic medium comprising a planar, polar surface covered with a monolayer comprising a compound having the structure described above, except that A can also be a saturated lower aliphatic group.

Abstract: Novel substituted phosphazene compounds are disclosed having the formula ##STR1## wherein w, x, y and z are integers the sum of which is from 3 to 6 with the proviso that w is at least 1 but equal to or less than (w+x+y+z)-1, x is from 1 to 5, y and z are from 0 to 2;R.sub.1 and R.sub.2 are the same or different and are C.sub.1 to C.sub.6 linear or branched alkyl;R.sub.3 is an unsubstituted or substituted aryl and n is 0 or an integer from 2 to 6; Q is --O--, ##STR2## --NR-- or --S--; Ar is ##STR3## R' and R" are the same or different and are C.sub.1 to C.sub.6 linear or branched alkyl, with the proviso that R" can also be hydrogen, wherein R.sub.1 and R.sub.2 are the same or different C.sub.1 to C.sub.4 linear or branched alkyl group and n is 0 or an integer from 2 to 6. These compounds display good solubilities in both organic and aqueous systems. Accordingly, they act as antioxidants in adhesive, sealant and coating compositions.

Abstract: Cyclic phosphazenes completely substituted with fluorinated phenoxy and m-perfluoroalkylphenoxy moieties in ratios ranging from about 1:1 to about 1:5 are disclosed. These compounds, either alone or as additives, are useful as high temperature lubricants.

Abstract: A process for producing an aryloxy-substituted phosphazene derivative represented by the formula(N.dbd.P).sub.n (OAr).sub.l Cl.sub.m-l R.sup.1.sub.p (III)which comprises reacting a chlorophosphazene derivative represented by the general formula(N.dbd.P).sub.n Cl.sub.m R.sup.1.sub.p (I)with, a hydroxy aryl compound represented by the general formulaHOAr (II)whereR.sup.1 represents hydroxy group, NH.sub.2 group, --OR.sup.4 group, --SR.sup.4 group or ##STR1## group, where R.sup.4, R.sup.5 and R.sup.6 represent independently an alkyl group, an alkenyl group, alkynyl group or an aryl group or one of R.sup.5 or R.sup.6 may be hydrogen or R.sup.5 and R.sup.

Abstract: A hydraulic fluid that remains solids-free at temperatures as low as about -30.degree. C. and has a pour point as low as about -42.degree. C. comprises a cyclic phosphazene oligomer mixture, the structural formula of each molecule of which contains 3 or 4 units selected at random from the group consisting of ##STR1## wherein R is a fluoroalkoxy group --OCH.sub.2 (CF.sub.2).sub.m CF.sub.2 Z, where Z is hydrogen or fluorine, and m is 0 or an integer from 1 to 10; R' and R" are different alkoxyalkyloxy groups in which linear or branched C.sub.1-12 alkoxy is substituted with linear or branched C.sub.1-12 alkoxy; with the proviso that all of R, R' and R" are present in the oligomer mixture.

Abstract: The present invention provides an antistatic composition comprising a binder, a cyclic phosphazene, and a salt that complexes with the cyclic phosphazene. The cyclic phosphazene has the general formula ##STR1## wherein x is 3 or 4.

Abstract: Synthetic lubricants of the formula: ##STR1## wherein, n is from 3 to 10; X and X' are NH or NH.sub.2, with the proviso that X and X' are not both NH.sub.2 ; Rf and Rf' are Y(C.sub.3 F.sub.6 O).sub.l CFZCO, Y(C.sub.3 F.sub.6 O).sub.l (CF.sub.2 O).sub.m CFZCO, Y(C.sub.2 F.sub.4 O).sub.l (CF.sub.2 O).sub.m CFZO, Y(CF.sub.2).sub.l-1 CO, Y(CF.sub.2).sub.l- CH.sub.2 CO, and Y(CF.sub.2).sub.l-1 CH.sub.2 CH.sub.2 CO, wherein l>m, l is an integer from 3 to 150, m is an integer from 1 to 50, Y is H--, F--, CF.sub.3 --, C.sub.2 F.sub.5 --, C.sub.3 F.sub.7 --, CF.sub.3 O--, C.sub.2 F.sub.5 O--, or C.sub.3 F.sub.7 O--, and Z is F--, CF.sub.3 --, or C.sub.2 F.sub.5 --. The synthetic lubricants have enhanced adsorption on metals, graphite, amorphous carbon, and other inorganic materials, have improved corrosion protection and load resistance properties, a favorable lubricating behavior, and low combustibility.

Abstract: This invention relates to a process for preparing compounds of the formula,N.sub.3 P.sub.3 (R.sub.1).sub.n (R.sub.2).sub.6-nwherein R.sub.1 is an aminophenoxide; R.sub.2 has up to 6 carbon atoms and is an alkoxy, an alkenoxy, a fluoro-substituted alkoxy, a fluoro-substituted alkenoxy or an aryloxy radical; and n is a whole integer .gtoreq.1 and .ltoreq.6. The process comprises reacting a chlorocyclotriphosphazene with an R.sub.1 salt to form an R.sub.1 -chlorocyclotriphosphazene which is further reacted with an R.sub.2 salt.Novel compounds of the formula,N.sub.3 P.sub.3 (R.sub.1).sub.n Cl.sub.6-nare also disclosed.

Abstract: The present invention provides a novel cyclic phosphate such as 1,3-dioxa-2-phospha-6-thia-cyclooctane-2-(dodecylthiodi(ethyleneoxy)-2-oxi de, and its use as an anti-wear, anti-oxidant, and/or friction modifying agent for oleaginous compositions such as fuels, and lubricating oils particularly automatic transmission fluids. A new use of overbased metal phenates and/or sulfonates as friction stability promoters for conventional friction modifying agents is also provided.

Abstract: 4-Aminophenoxy cyclotriphosphazenes are reacted with maleic anhydride to produce maleamic acids which are converted to the maleimides. The maleimides are polymerized. By selection of starting materials (e.g. hexakis amino or trisaminophenoxy-trisphenoxy-cyclotriphosphazenes), selection of molar proportions of reactants, use of mixtures of anhydrides and use of dianhydrides as bridging groups a variety of maleimides and polymers are produced. The polymers have high limiting oxygen indices, high char yields and other useful heat and fire resistant properties making them useful as, for example, impregnants of fabrics.

Abstract: This invention relates to phenoxy- and isopropoxyaminophenoxycyclotriphosphazenes and to a process for their preparation. The process comprises reacting R-chlorocyclotriphosphazene with an inorganic salt of aminophenoxide. The reaction takes place in the presence of an inert organic solvent and at a temperature within the range of from about 20.degree. C. to about 150.degree. C.

Abstract: This invention relates to R.sub.1, i.e., phenoxy-, halophenoxy- and isopropoxy- hydroxymethylphenoxycyclotriphosphazenes and to a process for their preparation. The process comprises reacting R.sub.1 -chlorocyclotriphosphazene with a salt of hydroxymethylphenoxide. The reaction takes place in the presence of an inert organic solvent and at a temperature within the range of from about 20.degree. C. to about 150.degree. C. The invention also relates to R.sub.1 -hydroxymethylphenoxycyclotetraphosphazenes. Also disclosed is a process for preparing a mixture of R.sub.1 -hydroxymethylcyclotriphosphazene and R.sub.1 -hydroxymethylcyclotetraphosphazene by reacting a mixture of R.sub.1 -chlorocyclotriphosphazene and R.sub.1 -chlorocyclotetraphosphazene with a hydroxymethylphenoxide salt.

Abstract: This invention relates to R.sub.1, R.sub.2 -hydroxyphenoxycyclotriphosphazenes and to a process for their preparation. R.sub.1 is a phenoxy-, halophenoxy- or an isopropoxy- group while R.sub.2 is a hydroxyphenoxy- or a bis-phenoxy A group. The process comprises reacting R.sub.1 -chlorocyclotriphosphazene with an R.sub.2 salt. The reaction takes place in the presence of an inert organic solvent and at a temperature within the range of from about 20.degree. C. to about 150.degree. C.

Abstract: A fluoroalkoxy cyclic phosphonitrile ester represented by the formula (1)[H(CF.sub.2 CF.sub.2)mCH.sub.2 O].sub.2 n-l[CF.sub.3 CF.sub.2 CH.sub.2 O]lPnNn (1)wherein (CF.sub.2 CF.sub.2)m is a single segment of the unit (CF.sub.2 CF.sub.2) multiplied by an integer or indicates conjoint presence of segments having different chain lengths and each comprising the unit (CF.sub.2 CF.sub.2) multiplied by an integer, m is 2 in the case of the single segment or, in the case of the presence of segments of different chain lengths, represents the average of the chain lengths, means the average number of repeating units (CF.sub.2 CF.sub.2) and is in the range of 1.3.ltoreq.m.ltoreq.2.8, l is in the range of 2n-1.gtoreq.l.gtoreq.1, and n is the number of repeating PN units of the phosphonitrile cyclic skeleton, or represents the average number of repeating PN units and is a real number in the range of 3.ltoreq.n.ltoreq.4.3 when rings of different numbers of repeating units are conjointly present.

Abstract: A polyphosphazene hydraulic fluid that remains solids-free on storage at temperatures down to -30.degree. C. over an extended period can be made by reacting a solution of sodium phenoxide, sodium m-methylphenoxide, sodium p-methylphenoxide and sodium trifluoroethoxide with a small stoichiometric excess of cyclic phosphonitrilic chloride oligomer, mainly trimer, and then reacting the remaining replaceable chlorine atoms with a solution of sodium trifluoroethoxide.

Abstract: The reaction of alkali metal with aromatic hydroxy compounds is promoted by inclusion of an alcohol in the reaction mixture. The alkali metal aryloxide formed can be reacted with phosphonitrilic chloride polymers to make polyaryloxyphosphazenes.

Abstract: Tests show that 2,2,4,4,6,6-hexaaminocyclotriphosphazatriene, 2-phenoxy-2,4,4,6,6-pentaaminocyclotriphosphazatriene, 2,4-diphenoxy-2,4,6,6-tetraaminocyclotriphosphazatriene and 2,4,6-triphenoxy-2,4,6-triaminocyclotriphosphazatriene (also frequently called phosphonitrilic derivatives) of the formula ##STR1## are highly effective inhibitors of urease activity in agricultural soil systems wherein(1) R.sub.1 . . . R.sub.3 '=NH.sub.2 or(2) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.2 =R.sub.3 =NH.sub.2 and R.sub.1 =OC.sub.6 H.sub.5 or(3) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.3 =NH.sub.2 and R.sub.1 =R.sub.2 =OC.sub.6 H.sub.5 or(4) R.sub.1 '=R.sub.2 '=R.sub.3 '=NH.sub.2 and R.sub.1 =R.sub.2 =R.sub.3 =OC.sub.6 H.sub.5.

Abstract: A functional fluid composition is provided which comprises a plurality of different phosphazene compounds of the general formula (P=N).sub.n (R).sub.a (R').sub.b (R").sub.c (R'").sub.d wherein R is at least one alkoxy moiety described by the general formula --OCH.sub.2 (CF.sub.2).sub.y X, with X being hydrogen or fluorine and y being equal to 1 to about 10; R', R" and R'" are different aryloxy moieties, each of R', R" and R'" being selected from the group consisting of phenoxy, alkoxy phenoxys, alkyl phenoxys, chlorinated phenoxys, fluorinated phenoxys, aryl phenoxys, phenoxy phenoxys, fluoroalkyl phenoxys, fluoroalkoxy phenoxys, chlorinated phenoxy phenoxys, fluorinated phenoxy phenoxys and mixtures thereof; n is equal to 3 to about 4 for each of said phosphazene compounds, each of a, b, c and d is equal to or greater than zero such that the sum a+b+c+d is equal to 2n; and for the composition as a whole, the average value of each of a, b, c and d is greater than 0.

Abstract: A process for the preparation of certain phosphazene esters. The process is characterized by its utilization of a phase transfer catalyst, which may be either a quaternary ammonium compound or a quaternary phosphonium compound.