The Phosphorus Is In A Ring Patents (Class 558/73)
  • Patent number: 11292805
    Abstract: A method for preparing the cyclic phosphonate compound of Formula I is described. The method significantly improves the stereoselectivity of the compound with the required configuration.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: April 5, 2022
    Assignee: GANNEX PHARMA CO., LTD.
    Inventors: Jinzi Jason Wu, Bailing Yang, Bin Liang
  • Patent number: 9580532
    Abstract: The present invention is directed to a functionalized elastomer comprising the reaction product of Y and Z, wherein Y is a copolymer of a first monomer and a second monomer, wherein the first monomer is selected from the group consisting of 1,3-butadiene, isoprene, and styrene; and the second monomer is selected from the group consisting of formula 1 and 2 wherein B is boron; O is oxygen; R1 and R2 are independently linear or branched alkyl groups containing 1 to 10 carbon atoms; R3 is hydrogen or a linear or branched alkyl group containing 1 to 10 carbon atoms; and R4 is a linear or branched alkane diyl group containing 1 to 20 carbon atoms, or a bridging aromatic group; and Z is a compound of formula 3 where R5 is phenylene, a linear or branched alkane diyl group containing from 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing from 1 to 10 carbon atoms; and Q is hydrogen, bromine, or a functional group comprising
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: February 28, 2017
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Margaret McGuigan Flook, Inigo Gottker genannt Schnetmann, Hannes Leicht, Stefan Mecking
  • Patent number: 9574024
    Abstract: The present invention is directed to a method of making a functionalized elastomer, comprising the steps of: forming a copolymer Y by copolymerizing a first monomer and a second monomer, wherein the first monomer is selected from the group consisting of 1,3-butadiene, isoprene, and styrene; the second monomer is selected from the group consisting of formula 1 or 2 wherein B is boron; O is oxygen; R1 and R2 are independently linear or branched alkyl groups containing 1 to 10 carbon atoms; R3 is hydrogen or a linear or branched alkyl group containing 1 to 10 carbon atoms; and R4 is a linear or branched alkane diyl group containing 1 to 20 carbon atoms, or a bridging aromatic group; and reacting the copolymer Y with a compound Z to form the functionalized elastomer, wherein Z is a compound of formula 3 where R5 is phenylene, a linear or branched alkane diyl group containing from 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups c
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: February 21, 2017
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Margaret McGuigan Flook, Inigo Gottker genannt Schnetmann, Hannes Leicht, Stefan Mecking
  • Patent number: 8791229
    Abstract: A series of novel phosphorus-containing compounds having the following formula is provided: in which: R1-R4, A, Q and m are as defined in the specification. A process for the preparation of the compound of formula (I) is also provided. A polymer of formula (PA), and preparation process and use thereof are further provided. A polymer of formula (PI), and preparation process and use thereof are also provided.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 29, 2014
    Assignees: Chang Chun Plastics Co., Ltd., National Chung Hsing University
    Inventors: Ching-Hsuan Lin, Tsung Li Lin, Yu-Ting Fang, Kuen-Yuan Hwang, An-Pang Tu
  • Patent number: 8674130
    Abstract: A process for producing a cyclic alkylene phosphorohalidite, which comprises reacting a specific phosphorus trihalide with a specific alkylene glycol compound under conditions where the phosphorus trihalide is present in an excess amount relative to the amount of the alkylene glycol compound in the reaction system to order to obtain the cyclic alkylene phosphorohalidite by reacting the alkylene glycol compound with the phosphorus trihalide; and a process for producing a cyclic phosphoric acid ester by using the obtained cyclic alkylene phosphorohalidite as a raw material.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: March 18, 2014
    Assignee: Daihachi Chemical Industry Co., Ltd.
    Inventors: Toshiya Hamada, Sakiko Hamada
  • Patent number: 8598307
    Abstract: A series of novel phosphorus-containing compounds having the following formula is provided: in which: R1-R4, A, Q and m are as defined in the specification. A process for the preparation of the compound of formula (I) is also provided. A polymer of formula (PA), and preparation process and use thereof are further provided. A polymer of formula (PI), and preparation process and use thereof are also provided.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 3, 2013
    Assignees: Chang Chun Plastics Co., Ltd., National Chung Hsing University
    Inventors: Ching-Hsuan Lin, Tsung Li Lin, Yu-Ting Fang, Kuen-Yuan Hwang, An-Pang Tu
  • Patent number: 8513452
    Abstract: A method synthesizing homoallylic or homopropargylic alcohols was developed to react aldehydes with allyl boronates, such as allylboronic acid pinacol ester, or allenylborates in the presence of a catalytic amount of a chiral binaphthyl-derived chiral phosphoric acid. The method showed enhanced enantiocontrol and chemical yield, which increased with lower temperatures. A large series of aldehydes were tested under these catalytic conditions and wide successful substrate scope was found, including aryl, heteroaryl, aromatic aldehydes, heteroaryl aldehydes, ?,?-unsaturated aldehydes and aliphatic aldehydes, and alkyl aldehydes. Likewise, the use of crotyl boronates (E and Z) were successfully reacted with aryl aldehydes under the conditions to allow for highly enantio- and diasteo-selective crotylation.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: August 20, 2013
    Assignee: University of South Florida
    Inventors: Jon Clarence Antilla, Pankaj Jain
  • Patent number: 8394512
    Abstract: The present invention relates to new phosphaphenanthrene compounds with excellent light emitting property and an organic light emitting diode (OLED) using the same.
    Type: Grant
    Filed: April 5, 2008
    Date of Patent: March 12, 2013
    Assignee: Inktec Co., Ltd.
    Inventors: Kwang Choon Chung, Hyun-Nam Cho, Ik-Kyu Park, Ji-Hoon Yoo, Ae-Ran Hyun, Yun-Ho Jung
  • Patent number: 8293865
    Abstract: A series of novel phosphorus-containing compounds having the following formula is provided: in which: R1-R4, A, Q and m are as defined in the specification. A process for the preparation of the compound of formula (I) is also provided. A polymer of formula (PA), and preparation process and use thereof are further provided. A polymer of formula (PI), and preparation process and use thereof are also provided.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: October 23, 2012
    Assignees: Chang Chun Plastics Co., Ltd., National Chung Hsing University
    Inventors: Ching-Hsuan Lin, Tsung Li Lin, Yu-Ting Fang, Kuen-Yuan Hwang, An-Pang Tu
  • Patent number: 8278375
    Abstract: Mixtures of three types of linear, branched or cyclic phosphates are useful flame retardants, especially for thermoplastic resins or as functional additives in polymer matrices.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: October 2, 2012
    Assignee: Rhodia UK Limited
    Inventors: Vincent Schanen, Dwight Shamblee, Gleb Priimov, Julie Ann Salter
  • Patent number: 8097749
    Abstract: The present invention relates to a process for preparation of a phosphoromonochloridite in high yield by contacting phosphorus trichloride (PCl3) with an aromatic diol in a solution of one or more organic solvents under reaction conditions sufficient to produce the phosphoromonochloridite. The reaction is carried out by adding a feed solution containing the aromatic diol dissolved in a first organic solvent into a reaction zone containing PCl3, and optionally one or more second organic solvents, the addition being conducted so as to maintain substantially isothermal process conditions. The reaction solution comprises greater than 0.01 to less than 5 mole percent of a nitrogen base.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: January 17, 2012
    Inventor: Glenn A. Miller
  • Publication number: 20110124899
    Abstract: The Invention relates to a method for preparing a combretastatin (A): formula (I) in the form of a base or of an addition salt with an acid, which comprises coupling, in the presence of a base and of T3P, the salt of the (Z)-amino compound of formula (II) with a doubly protected L-serine derivative of formula (III) in which PG denotes a group protecting the amine function, so as to obtain the compound of formula (Z)-(Ib): formula (IV), then deprotecting and opening the ring of (Z)-(Ib) in the presence of an acid, so as to obtain the combretastatin (A) in the form of a salt; and, optionally, adding a base, so as to obtain the combretastatin (A) in the form of a base, the salt of the (Z)-amino compound having been obtained by enrichment of the salt of the amino compound of formula (V) in (Z) isomer.
    Type: Application
    Filed: August 27, 2010
    Publication date: May 26, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Marc FREDERIC, Sylviane LUTZ, Joel MALPART, Philippe MASSON, Stephane MUTTI
  • Publication number: 20100298470
    Abstract: The present invention relates to the production of organophosphorus compounds, in particular 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) or derivatives thereof which have been known for many years in prior art. They are used preferably as additives for polymers. In particular the use of DOPO and derivatives thereof as flame retardants for polymers, such as e.g. polyesters, polyamides, epoxy resins, has proved to be advantageous.
    Type: Application
    Filed: October 16, 2008
    Publication date: November 25, 2010
    Inventors: Andreas Kaplan, René Gisler, Christopher Kohl
  • Patent number: 7728162
    Abstract: A novel process for preparing in a high purity and in a high yield phosphorus compounds having a phosphate-phosphonate bond within one molecule, along with only a small amount of a by-product, without being restricted by the kind of a phosphonate having an alcoholic hydroxyl group which is a raw material, without using a catalyst such as magnesium chloride, but only using a nitrogen-containing basic compound.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: June 1, 2010
    Assignee: Daihachi Chemical Industry Co., Ltd.
    Inventors: Kazuo Fujimoto, Sakiko Tanaka
  • Patent number: 7205285
    Abstract: The invention provides novel ?-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic ?-lactamase inhibitors presently available, and which do not possess a ?-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as ?-lactamase inhibitors and as antibiotics.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: April 17, 2007
    Assignee: Methylgene, Inc.
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt
  • Patent number: 7135583
    Abstract: A novel process for preparation of alkenylphosphine oxides or alkenylphosphinic acid esters provided by which the objective compounds can be easily, safely and efficiently synthesized and easily separated and purified with little formation of by-products. Specifically, a process of conducting the addition reaction of an easily available secondary phosphine oxide or hydrogen phosphinic acid ester with an acetylene compound with a catalyst containing a Group 9 or 10 metal of the periodic table to thereby obtain the corresponding alkenylphosphine oxide or alkenylphosphinic acid ester.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: November 14, 2006
    Assignees: Japan Science and Technology Corporation, National Institute of Advanced Industrial Science & Technology
    Inventors: Li-biao Han, Chang-qiu Zhao, Masato Tanaka
  • Patent number: 7126021
    Abstract: The present invention relates to a process for the preparation of ?-phosphorated nitroxide radicals which consist in preparing, in a first step, an aminophosphonate by reaction of a carbonyl compound, of a primary amine and of a phosphorous compound in the presence of a Lewis acid and then, in a second step, in oxidizing the said crude aminophosphonate using nonhalogenated organic peracids in a water/organic solvent two-phase medium with an aqueous phase buffered at a pH ranging from 5 to 12.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: October 24, 2006
    Assignee: Arkema (formerly Atofina)
    Inventors: Olivier Guerret, Jean-Luc Couturier, Christophe Le Mercier
  • Patent number: 7122699
    Abstract: The invention relates to a process for the preparation of organic boronic acid derivatives involving the reaction of an organic compound with diboronic acid in the presence of a Group 8-11 metal catalyst.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: October 17, 2006
    Assignee: Boron Molecular Limited
    Inventors: Sebastian Mario Marcuccio, Mary Rodopoulos, Helmut Weigold
  • Patent number: 6949667
    Abstract: Novel alkenylphosphonic acid esters of the following general formula (I): R1CH?CR2[P(O)(OCR3R4CR5R6O)]??(I) and a simple process for the preparation thereof are provided by the use of secondary cyclic phosphonic acid esters as the starting material.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: September 27, 2005
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Li-Biao Han, ChangQiu Zhao, Masato Tanaka
  • Patent number: 6946569
    Abstract: Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymmetric reactions.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: September 20, 2005
    Assignee: The Penn State Research Foundation
    Inventor: Xumu Zhang
  • Patent number: 6872712
    Abstract: Cyclic glycerophosphates as well as some analogs thereof (CGs) are shown to increase phosphorylation of intracellular proteins in various cells. Such activity is not found with linear ? or ? glycerophosphates. The phosphorylating activity of the CGs render them useful in the prevention and treatment of various disorders and diseases such as, for example, different kinds of malignancies as well as disorders involving hormone and hormone-like signaling. The CGs are also useful for promotion of target cell differentiation and for detection of abnormal conditions in target cells.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: March 29, 2005
    Assignee: Yeda Research and Development Co. Ltd.
    Inventor: Meir Shinitzky
  • Publication number: 20040191926
    Abstract: Methods for discovery of enzyme ligands and inhibitors are disclosed. The methods comprise the creation and testing of combinatorial libraries comprising an active site-targeted component, a linker component and a peripheral site-targeted component. The methods also comprise a novel assay for determining whether a compound is a ligand of an enzyme. The assay evaluates whether the compound can inhibit the binding of a known ligand of the active site of the enzyme to a mutant of the enzyme that can bind the enzyme substrate but cannot catalyze an enzymatic reaction with the substrate. Various ligands and inhibitors of protein tyrosine phosphatase 1B (PTP1B) are also disclosed. These ligands and inhibitors were discovered using the above methods. One particular inhibitor discovered using the invention methods has the highest specificity and affinity of any PTP1B inhibitor discovered to date.
    Type: Application
    Filed: March 25, 2004
    Publication date: September 30, 2004
    Inventors: Zhong-Yin Zhang, David S Lawrence
  • Publication number: 20040164279
    Abstract: A solid phosphite composite, having at least a portion in amorphous form, which includes at least one, preferably two or more phosphite antioxidants or alternatively at least one phosphite and at least one other polymer additive. The phosphites, at least one of which can initially be a liquid, are generally uniformly distributed since they are melt blended. A desired class of phosphites are the bis(arylalkylphenyl)pentaerythritol diphosphites, at least a portion of which is in amorphous form.
    Type: Application
    Filed: February 13, 2004
    Publication date: August 26, 2004
    Inventors: Donald R. Stevenson, Satyan Kodali, Carroll W. Larke
  • Patent number: 6743936
    Abstract: There are disclosed amphoteric nano-sized metal oxide particles functionalized with silyl esters of a phosphonate and composites thereof with an acrylate-based monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Also disclosed are the method making such functionalized particular by reacting a metal oxide with a silyl ester of a phosphonate in the presence of a non-aqueous solvent and in an inert atmosphere and the method of making the composites wherein the functionalized particles are admixed with an acrylate-based matrix monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Further disclosed is the method of dental repair wherein the composites are applied to a tooth and photopolymerized.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: June 1, 2004
    Assignees: Southwest Research Insittute, Board of Regents, The University of Texas System
    Inventors: Stephen T. Wellinghoff, Hong Dixon, Henry R. Rawls, Barry K. Norling
  • Patent number: 6727377
    Abstract: Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymmetric reactions.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: April 27, 2004
    Assignee: The Penn State Research Foundation
    Inventor: Xumu Zhang
  • Publication number: 20040072142
    Abstract: The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.
    Type: Application
    Filed: July 8, 2003
    Publication date: April 15, 2004
    Inventors: Adelbert Bacher, Meinhart H. Zenk, Petra Adam, Wolfgang Eisenreich, Monika Fellermeir, Stefan Hecht, Felix Rohdich, Christoph A. Schuhr, Juraithip Wungsintaweekul
  • Patent number: 6693212
    Abstract: The invention relates to tris-(oxalato)phosphates of the general formula M[P(C2O4)3] wherein M=H, a metal or N(R1R2R3R4), where R1, R2, R3, R4, are independently H or an alkyl group comprising 1 to 8 C atoms. The invention also relates to a method for preparing such compounds as well as to their use.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: February 17, 2004
    Assignee: Chematall GmbH
    Inventors: Ulrich Wietelmann, Klaus Schade, Uwe Lischka
  • Publication number: 20030199017
    Abstract: This invention has as its object a method for releasing a product by subjecting a compound of Formula (II′): R′7R′8(HX)C1-C2(YH)R′9R′10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II′): R′7 to R′10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula -NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II′). The released product can be a volatile molecule or an active substance or else a specific product.
    Type: Application
    Filed: December 2, 2002
    Publication date: October 23, 2003
    Applicant: Proteus
    Inventors: Jean-Louis Reymond, Denis Wahler, Frabrizzio Badalassi, Hong-Khanh Nguyen
  • Publication number: 20030195368
    Abstract: The invention relates to the bisphosphites of the general formula(I), wherein R1, R2, R3, $4 R5 R6 represent H, an aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aliphatic-aromatic hydrocarbon group with 1 to 50 carbon atoms, F, Cl, Br, I, —OR7, —COR7, —CO2R7, —CO2M, —SR7, —SO2R7, —SOR7, —SO3R7, —SO3M, —SO2NR7R8, NR7R8, N═CR7R8, NH2, wherein R1 to R6 are the same or different and can be covalently linked with each other, R7, R8 represent H, a substituted or unsubstituted, aliphatic or aromatic hydrocarbon group with 1 to 25 carbon atoms, which are the same or different, M represents an alkali metal, alkaline earth metal, ammonium, phosphonium ion; Q represents a bivalent, aliphatic alicyclic, aliphatic-alicyclic, heterocyclic, aromatic, aliphatic-aromatic hydrocarbon group with 1 to 50 carbons atoms, W, X represent aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromati
    Type: Application
    Filed: April 24, 2003
    Publication date: October 16, 2003
    Inventors: Dirk Rottger, Renat Kadyrov, Armin Borner, Detlef Selent, Dieter Hess
  • Patent number: 6613922
    Abstract: Chiral di-phosphonites and phosphhours diamides based on the ps-ortho disubstituted p-cyclophane skeleton are good ligands for transition metals, notably rhodium, iridium and ruthenium. Preferably, the transition metals are linked to the ligands by a diene compound chosen from 2,5-Norbornadiene (NBD) and 1,5-Cyclooctadiene (COD).
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: September 2, 2003
    Assignee: Chirotech Technology Limited
    Inventors: Antonio Zanotti-Gerosa, Christophe Guillaume Malan, Julian Henschke, Daniela Herzberg
  • Patent number: 6573407
    Abstract: Bisphenol-phosphorus compound complexes represented by the following general formula (1) are disclosed (R1 to R4 represent hydrogen atom or a group that can be a substituent on a benzene ring; L represents —S— group or a —CHR5— group where R5 represents hydrogen atom or an alkyl group; and R6 to R8 represent an alkyl group, an aryl group, a heterocyclic group etc.). The present invention provides reducing agents that can realize thermally processed image recording materials that can provide sufficient image density at a practical reaction temperature (specifically 100-140° C.) and within a practical reaction time (specifically 1-30 seconds), and can sufficiently suppress the coloration of white portions when the materials are stored in a dark place after the development.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: June 3, 2003
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Makoto Suzuki, Yasuhiro Yoshioka
  • Patent number: 6465684
    Abstract: A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process permits the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an enantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at least one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: October 15, 2002
    Assignee: DSM N.V.
    Inventors: Ton R. Vries, Hans Wijnberg, Erik Van Echten, Lumbertus A. Hulshof, Quirinus B. Broxterman
  • Patent number: 6391926
    Abstract: An optically active binaphthol derivative of the following formula (1) or (2), an optically active phosphate derivative of the following formula (3) or, (4), processes for their production, and an asymmetry identifying agent comprising the derivative of the formula (3) or (4):
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: May 21, 2002
    Assignee: Tosoh Corporation
    Inventor: Junji Inanaga
  • Publication number: 20020022607
    Abstract: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
    Type: Application
    Filed: March 1, 2001
    Publication date: February 21, 2002
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt
  • Patent number: 6339161
    Abstract: Olefin co- or homopolymers having a good molecular weight and short chain branching may be prepared in the presence of a tridentate complex of a Group 8, 9 or 10 metal.
    Type: Grant
    Filed: February 19, 2001
    Date of Patent: January 15, 2002
    Assignee: Nova Chemicals (International) S.A.
    Inventors: Wei Xu, Qinyan Wang, Ryan Paul Wurz
  • Patent number: 6274745
    Abstract: A binaphthol monophosphoric acid derivative of the following formula (1), (2), (3) or (4): wherein each of R1, R2, R3 and R4 which are independent of one another, is hydrogen, a C2-20 linear or branched alkenyl group, a C2-20 linear or branched alkynyl group, a phenyl group, a phenyl group having its nucleus substituted at the 1- to 4-carbon atom by a C1-10 linear or branched alkyl group, a phenyl group having its nucleus substituted at the 1- to 4-carbon atom by a C2-10 linear or branched alkenyl group, a phenyl group having its nucleus substituted at the 1- to 4-carbon atom by a C2-10 linear or branched alkynyl group, a naphthyl group or a C3-8 cycloalkyl group, provided that R1 to R4 are not simultaneously hydrogen, wherein each of R5, R6, R7 and R8 which are independent of one another, essentially the same as R1, R2, R3 and R4.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: August 14, 2001
    Assignee: Tosoh Corporation
    Inventors: Junji Inanaga, Hiroshi Furuno
  • Patent number: 6235927
    Abstract: A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process pets the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an onantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at lea one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: May 22, 2001
    Assignee: DSM N.V.
    Inventors: Ton R. Vries, Hans Wijnberg, Erik Van Echten, Lumbertus A. Hulshof, Quirinus B. Broxterman
  • Patent number: 6184275
    Abstract: A crystalline polymer composition comprising 100 parts by weight of a crystalline polymer and 0.005 to 5 parts by weight of a compound represented by formula (I): wherein R1 and R2 each independently represent an alkyl group having 1 to 9 carbon atoms; R3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and M represents an alkali metal, the compound having a chlorine content of 500 ppm or less.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: February 6, 2001
    Assignee: Asahi Denka Kogyo Kabushiki Kaisha
    Inventors: Masayuki Takahashi, Etsuo Tobita
  • Patent number: 6075159
    Abstract: A phosphite represented by the formula (I): ##STR1## wherein n repesents 1 or 2; A represents alkylene; B represents a direct bond or alkylene; one of Y and Z represents a hydroxyl group, alkoxy or aralkyloxy, and the other one represents a hydrogen atom or alkyl; X represents a group of formula (II): ##STR2## wherein R.sup.1 and R.sup.2 represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkylcycloalkyl group, an aralkyl group or a phenyl group; R.sup.3 represents a hydrogen atom or an alkyl group; and R.sup.4 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an alkylcycloalkyl group, an aralkyl group or a phenyl group, or R.sup.4 may be combined to form a direct bond, a sulfur bond (--S--), or an unsubstituted or substituted methylene group; R.sup.5 and R.sup.6 independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkylcycloalkyl group, an aralkyl group or a phenyl group;R.sup.8 represents a hydrogen atom or an alkyl group; andR.sup.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: June 13, 2000
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Naoki Inui, Taketoshi Kikuchi, Kanako Fukuda, Takashi Sanada
  • Patent number: 5990337
    Abstract: The invention relates to a process for the preparation of phosphorus-containing compounds of the formula (I) ##STR1## where R.sup.1 and R.sup.2 are identical or different and are a straight-chain or branched alkyl radical having 1 to 8 carbon atoms, a cyclohexyl-, cyclopentyl-, aryl-, halogen-, (C.sub.1 -C.sub.6)-alkyl- or (C.sub.1 -C.sub.6)-alkoxy-substituted aryl radical, where R.sup.1 and R.sup.2, together with the phosphorus atom and the oxygen atom, can also form a ring, in particular an oxaphosphorin ring, which comprises metering acrylonitrile at elevated temperature into a compound of the formula (II) ##STR2## where R.sup.1 and R.sup.2 are as defined above.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: November 23, 1999
    Assignee: Ticona GmbH
    Inventor: Hanss-Jerg Kleiner
  • Patent number: 5847184
    Abstract: The present invention relates to a process for preparing of phosphorus-containing dicarboxylic acids of the formula (I) ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each a straight-chain or branched alkyl radical having from 1 to 8 carbon atoms, a cycloaliphatic radical having 5 or 6 carbon atoms in the ring, an unsubstituted or substituted aryl radical having from 6 to 10 carbon atoms, or R.sup.1 and R.sup.2 form, with inclusion of the phosphorus atom, a ring having from 5 to 8 members, and m and n are each, independently of one another 0 or 1, by reacting a compound of the formula (II) ##STR2## where R.sup.1, R.sup.2 and m are as defined above, with fumaric acid, maleic acid or itaconic acid in the presence of a saturated aliphatic monocarboxylic acid having a total of from 1 to 5 carbon atoms as solvent at from 100.degree. to 200.degree. C. under atmospheric pressure or superatmospheric pressure.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: December 8, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Hans-Jerg Kleiner
  • Patent number: 5705669
    Abstract: A process for the preparation of alkyl arylphosphinites of the formula (I) ##STR1## in which R.sup.1 is (C.sub.1 -C.sub.16)-alkyl, cyclohexyl, cyclopentyl, arylwhich can also be substituted by halogen, (C.sub.1 -C.sub.6)-alkoxy groupsR.sup.2 is aryl which can also be substituted by halogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.1 -C.sub.6)-alkoxy groups, where R.sup.1 and R.sup.2 together with the phosphorous atom can also form a ring andR.sup.3 is (C.sub.1 -C.sub.4)-alkyl, which comprises reacting halo(aryl) phosphines of the formula (II) ##STR2## in which R.sup.1, R.sup.2 have the meaning given above and X is halogen, with ammonia-containing alcohols of the formula (III)R.sup.3 OH (III)in which R.sup.3 has the meaning given above.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: January 6, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Hans-Jerg Kleiner
  • Patent number: 5639732
    Abstract: The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: June 17, 1997
    Assignee: Cephalon, Inc.
    Inventors: John P. Mallamo, Ron Bihovsky, Ming Tao, Gregory J. Wells
  • Patent number: 5550276
    Abstract: Compounds of the general formula I ##STR1## in which n is 1, 2 or 3 and in which X is oxygen or sulfur, T has the meaning of --S--, --S--S--, --S--S--, --S--S--S--S--, --S--S--S--S--S--, ##STR2## and Y has the meaning of ##STR3## in which Z has the meaning of --H, --COR.sup.13, --COOR.sup.13 or --CONHR.sup.13, and Q has the meaning of oxygen or --NR.sup.0 --, and R.sup.1, R.sup.2, R.sup.0, R.sup.4 and R.sup.13 are as defined in claim 1, with the proviso that the compound of the formula C.sub.2 H.sub.5 --S--CH.sub.2 CH(OH)--P(OC.sub.2 H.sub.5).sub.2 is excepted.The invention also relates to compositions containing the compounds of the formula I and organic materials, for example functional liquids and, in particular, lubricants.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 27, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Hermann O. Wirth, Hans-Helmut Friedrich, Kay S. Groninger
  • Patent number: 5530150
    Abstract: A phosphine compound represented by one of the formulas: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent a phenyl group or a phenyl group substituted with a halogen atom or a lower alkyl group or taken together form a divalent hydrocarbon group; and R.sup.3 and R.sup.4, which may be the same or different, each represent a lower alkyl group, a phenyl group or a phenyl group substituted with a halogen atom, a lower alkyl group or a lower alkoxy group or taken together form a divalent hydrocarbon group, and wherein R.sup.6 and R.sup.6' which may be the same or different, each represent a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.5, R.sup.5', R.sup.11 and R.sup.11' which may be the same or different, each represent a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom; or a pair of R.sup.5 and R.sup.6 or a pair of R.sup.5' and R.sup.6' may form a ring; R.sup.7 and R.sup.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: June 25, 1996
    Assignee: Takasago International Corporation
    Inventors: Hidemasa Takaya, Nozomu Sakai, Kyoko Tamao, Satoshi Mano, Hidenori Kumobayashi, Tetsuo Tomita, Takao Saito, Kazuhiko Matsumura, Yasushi Kato, Noboru Sayo
  • Patent number: 5391799
    Abstract: 6-Chloro-2,4,8,10-tetrabutyl-dibenzo[d,f][1,3,2]dioxaphosphepin and related phosphorochlorites are prepared by reaction of an appropriate bisphenol with phosphorus trichloride in the presence of a catalytic amount of 1-methyl-2-pyrrolidinone in toluene followed by heating the solution and stripping off the hydrogen chloride formed by a flow of nitrogen.
    Type: Grant
    Filed: March 1, 1994
    Date of Patent: February 21, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Stephen D. Pastor, Sai P. Shum
  • Patent number: 5237085
    Abstract: A process for the formation of pentaerythritol-based phosphorus heterocycles comprises the reaction of a pentaerythritol polyol, e.g., pentaerythritol, with a trivalent or pentavalent phosphorus compounds, e.g., a phosphorus oxytrihalide, a triorganophosphite, or a phosphorus trihalide, in an aryl phosphate solvent at elevated temperature.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: August 17, 1993
    Assignee: Akzo N V
    Inventors: Jeffrey E. Telschow, Edward D. Weil
  • Patent number: 5006658
    Abstract: A compound of Formula I or a salt thereof:Ar--Q--(CH.sub.2).sub.m --A--CH.sub.2).sub.n (CE.sup.1 .dbd.CE.sup.2).sub.a CE.sup.3 .dbd.CE.sup.4 CXNR.sup.1 R.sup.2 (1)whereAr is a 6-membered heteroaromatic ring containing, as the heteroatom or heteroatoms, one or two nitrogen atoms and is optionally substituted by one or more of halogen, cyano, C.sub.1-6 -alkyl (optionally substituted by halogen), or C.sub.1-6 -alkoxy (optionally substituted by one or more of halogen or C.sub.1-6 -alkyl), or RS(O).sub.x where x is 0, 1 or 2 and R is C.sub.1-6 -alkyl optionally substituted by one or more halogen atoms,Q is --CH.sub.2 -- or --O--,m and n are each independently 0 to 7,A is --CH.sub.2 -- or --O--,a is 0 or 1,E.sup.1 to E.sup.4 are independently hydrogen, C.sub.1-4 -alkyl or halo-C.sub.1-4 -alkyl or halogen,X is oxygen or sulphur, andR.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-6 -alkyl or C.sub.3-6 -cycloalkyl, either being optionally substituted by one or more of the C.sub.1-6 -alkyl, C.sub.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: April 9, 1991
    Assignee: The Wellcome Foundation Ltd.
    Inventor: Robert J. Blade
  • Patent number: 4885401
    Abstract: Transition metal-bis-phosphite catalyzed carbonylation processes, especially hydroformylation, as well as transition metal-bis-phosphite compositions, bis-phosphite ligands and transition metal-bis-phosphite catalysts.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: December 5, 1989
    Assignee: Union Carbide Corporation
    Inventors: Ernst Billig, Anthony G. Abatjoglou, David R. Bryant
  • Patent number: 4784782
    Abstract: Various heterocyclic compounds have been discovered that impart improved fuel economy and friction modification to lubricant and fuel compositions. These hetrocyclic compounds of the invention preferably contain nitrogen and may be further reacted with hydrocarbyl carboxylic acid acylating reactants or hydrocarbyl phenolic reactants to give higher molecular materials. These higher molecular weight materials have higher oil-solubility and impart dispersancy properties to lubricant and fuel compositions.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: November 15, 1988
    Assignee: The Lubrizol Corporation
    Inventors: Joseph W. Pialet, Paul E. Adams